Kyle J. Norton
The colon forms part of the digestive system including a large intestine that connects to the small intestines and the rectum plays a critical role in reabsorbing fluids processing waste products from the body and preparing for their elimination through the rectum.
Colon cancer is relatively very common and slowly growing and progresses cancer in a predictable way. The disease is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
Most cases of primary colon cancer start in the cells on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.
However, at the advanced stage, the tumor not only can spread to other healthy tissue and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.
The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.
According to the statistics by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer were diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
The 5-year survival rate for patients diagnosed with localized stage colorectal cancer is 90%. About 39% of patients are diagnosed at this early stage.
Researchers do not know the exact causes of the disease. However, they do know a history of polyps, ethnicity, a high-fat diet, and low fiber, an increase in age, and the long-term infection of colon diseases are some of the prevalent factors associated with the onset and progression of colon cancer.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
On finding a potential compound for the treatment of cancers, researchers examined the effects of diets containing cruciferous vegetables on colon cancer risk.
According to the experiments of* Expt. 1, with rats that were fed a vegetable-free (basal) diet or diets containing different lyophilized cruciferous vegetables in concentrations between 4 and 10%.
* Expt. 2, rats that were fed the basal diet or diets containing 10-22.6% fresh cruciferous vegetables. Diets were fed for 2 wk (Expt. 1) or 3 wk (Expt. 2) before and 7 wk (Expt. 1) or 12 wk (Expt. 2) after administration of the colon carcinogen 1,2-dimethylhydrazine.
Moreover, rats fed fresh vegetables were also injected with a low dose of carcinogen 18-24 h prior to termination.
According to the dietary information,
* Groups fed lyophilized vegetables did not differ in aberrant crypt foci (ACF), sialomucin-producing foci, or mucin-depleted foci (MDF) numbers.
Furthermore, all fresh vegetable diets significantly decreased ACF (approximately 40%) and MDF numbers, and the activities of the hepatic phase I enzyme CYP2E1 involved in drugs and alcohol metabolism did not differ among groups in either experiment.
Additionally, the levels of liver glutathione S-transferase (GST) and quinone reductase activities associated with detoxification did not differ among groups fed fresh vegetables, whereas the lyophilized cabbage diets decreased GST activity, compared with the basal diet.
Taken together, cruciferous vegetables may be considered functional foods for reducing the risk of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats by Arikawa AY1, Gallaher DD. (PubMed)
Tuesday, 26 September 2023
#Fennel #Exact Inhibits #Hypertension by Lowering Systolic Blood Pressure of SHR, Studies Show
Kyle J. Norton
Fennel may have a potential and positive effect on the improvement of cardiovascular activity, some scientists suggested.
The results of vascular and cardiovascular protective effects were reported by a number of universities including Birzeit University and published in online medical literature.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to investigate the vascular effects of aqueous extracts of Foeniculum vulgare leaves in pentobarbital-anaesthetised rats, researchers found that intravenous administration of the lyophilized boiled water extract exerted a significant dose-related reduction in arterial blood pressure, without affecting the heart rate or respiratory rate in compared to histamine antagonists.
However, the application of non-boiled aqueous extract showed very little hypotensive activity.
In contrast to the conventional medicine histamine antagonists, the hypotensive effect of the boiling water extract appeared not to be mediated by adrenergic, muscarinic, ganglionic, or serotonergic receptors.
Furthermore, in the examination of the cardiovascular effect of the main component of the oil, anethole isolated from tested guinea pig fennel oil in inhibited arachidonic acid, collagen-, ADP- and U46619-induced aggregation, researchers found that application of anethole displayed comparable NO-independent vasorelaxant activity at antiplatelet concentrations.
Anethole also prevented thrombin-induced clot retraction at concentrations similar to fennel oil in comparison of U46619-induced aggregation (IC(50) from 4 to 147 microg ml(-1)). These results were confirmed in tested mice with application F. Vulgare essential oil and anethole in a subacute treatment of 30 mg kg(-1)day(-1) for 5 days.
F. Vulgare essential oil and anethole also showed significant antithrombotic activity in preventing paralysis induced by collagen-epinephrine intravenous injection with 70% and 83% protection, respectively.
In the rat model, both F. Vulgare essential oil and anethole (100 mg kg(-1) oral administration) provided significant protection against ethanol-induced gastric lesions.
After taking into account other co and confounders, together with the collected information Dr. Tognolini M, the lead author said, " F. vulgare essential oil, and its main component anethole, a safe antithrombotic activity that seems due to their broad spectrum antiplatelet activity, clot destabilizing effect, and vasorelaxant action".
Further to reassess other cardiovascular activity of Foeniculum vulgare L, researchers at the UFR Physiologie-Pharmacologie, launched an investigation to compare the effects of Marrubium vulgare L. and Foeniculum vulgare L. in spontaneously hypertensive rats (SHR).
Interestingly, the oral application of Foeniculum extract exerted lowered the systolic blood pressure of SHR without induced change of normotensive Wistar-Kyoto rats (WKY).
These results were probably associated with to function of Foeniculum in increased water, sodium, and potassium excretion.
More importantly, Foeniculum extract hypertensive efficacy was decreased substantially in rats and mice presented with N-nitro-L-arginine.
The results indicated that fennel demonstrated vascular protective activity as a diuretic and a natriuretic.
Taken together, Fennel and its essential oil and bioactive compound anethole may be considered as a function substance in promoting cardiovascular and vascular activity, particularly in animal models with a high risk of cardiovascular disease.
Intake of fennel extract should be taken with extreme care as overdoses may induce liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis by Tognolini M1, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E.(PubMed)
(2) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
(3) The vascular action of aqueous extracts of Foeniculum vulgare leaves by Abdul-Ghani AS1, Amin R.(PubMed)
Fennel may have a potential and positive effect on the improvement of cardiovascular activity, some scientists suggested.
The results of vascular and cardiovascular protective effects were reported by a number of universities including Birzeit University and published in online medical literature.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to investigate the vascular effects of aqueous extracts of Foeniculum vulgare leaves in pentobarbital-anaesthetised rats, researchers found that intravenous administration of the lyophilized boiled water extract exerted a significant dose-related reduction in arterial blood pressure, without affecting the heart rate or respiratory rate in compared to histamine antagonists.
However, the application of non-boiled aqueous extract showed very little hypotensive activity.
In contrast to the conventional medicine histamine antagonists, the hypotensive effect of the boiling water extract appeared not to be mediated by adrenergic, muscarinic, ganglionic, or serotonergic receptors.
Furthermore, in the examination of the cardiovascular effect of the main component of the oil, anethole isolated from tested guinea pig fennel oil in inhibited arachidonic acid, collagen-, ADP- and U46619-induced aggregation, researchers found that application of anethole displayed comparable NO-independent vasorelaxant activity at antiplatelet concentrations.
Anethole also prevented thrombin-induced clot retraction at concentrations similar to fennel oil in comparison of U46619-induced aggregation (IC(50) from 4 to 147 microg ml(-1)). These results were confirmed in tested mice with application F. Vulgare essential oil and anethole in a subacute treatment of 30 mg kg(-1)day(-1) for 5 days.
F. Vulgare essential oil and anethole also showed significant antithrombotic activity in preventing paralysis induced by collagen-epinephrine intravenous injection with 70% and 83% protection, respectively.
In the rat model, both F. Vulgare essential oil and anethole (100 mg kg(-1) oral administration) provided significant protection against ethanol-induced gastric lesions.
After taking into account other co and confounders, together with the collected information Dr. Tognolini M, the lead author said, " F. vulgare essential oil, and its main component anethole, a safe antithrombotic activity that seems due to their broad spectrum antiplatelet activity, clot destabilizing effect, and vasorelaxant action".
Further to reassess other cardiovascular activity of Foeniculum vulgare L, researchers at the UFR Physiologie-Pharmacologie, launched an investigation to compare the effects of Marrubium vulgare L. and Foeniculum vulgare L. in spontaneously hypertensive rats (SHR).
Interestingly, the oral application of Foeniculum extract exerted lowered the systolic blood pressure of SHR without induced change of normotensive Wistar-Kyoto rats (WKY).
These results were probably associated with to function of Foeniculum in increased water, sodium, and potassium excretion.
More importantly, Foeniculum extract hypertensive efficacy was decreased substantially in rats and mice presented with N-nitro-L-arginine.
The results indicated that fennel demonstrated vascular protective activity as a diuretic and a natriuretic.
Taken together, Fennel and its essential oil and bioactive compound anethole may be considered as a function substance in promoting cardiovascular and vascular activity, particularly in animal models with a high risk of cardiovascular disease.
Intake of fennel extract should be taken with extreme care as overdoses may induce liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis by Tognolini M1, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E.(PubMed)
(2) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
(3) The vascular action of aqueous extracts of Foeniculum vulgare leaves by Abdul-Ghani AS1, Amin R.(PubMed)
#Lutein and #Zeaxanthin Foound in #Carotenoids Inhibit the Early Onset of Age-Related Macular Degeneration (#AMD), Researchers Say
Kyle J. Norton
Age-related macular degeneration (AMD) is a medical condition that causes slow and progressive vision loss in the central vision found in people over age 60. Over time, AMD may affect the reading as the blurred area increases in size.
In other words, AMD may cause significant visual disability.
Most cases of the early stage of AMD were diagnosed during routine eye health examinations.
At the early stage, age-related macular degeneration is asymptomatic. However, most patients experience symptoms of shadowy areas in their central vision or unusually fuzzy or distorted vision, particularly in seeing wavy or blurred, with some dark areas at the center.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.
Besides aging, some researchers suggest that other factors such as smoking, family history, gender, race, sun exposure, diet, and obesity also increase the risk of AMD developing.
However, most people with some of the risk factors have never developed AMD.
Dr. Sara Velilla, the lead scientist in the investigation of the risk of smoking on AMD wrote, "Smoking is the most important modifiable risk factor for AMD development and progression".
And, "...smoking by itself promotes molecular and pathological changes that may establish an ideal macular microenvironment for the development of AMD: vascular inflammation and endothelial dysregulation [47–56], oxidative damage [57–80], toxic damage, and histopathological changes [81–87]".
The results strongly suggested, that if you smoke, your risk of age-related macular degeneration is increased by many folds.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomatoes, pumpkins, carrots, corn, and daffodils.
With an aim to find the potential compound for the prevention and treatment of age-related macular degeneration, researchers evaluated lutein and zeaxanthin (L/Z) are the predominant carotenoids accumulated in the retina of the eye.
Lutein and zeaxanthin (L/Z) have been found to improve and enhance eye health in the general population, particularly in the elderly.
According to the chemical analysis, the effective levels of L/Z achieved through diet alone, with values of 5 mg and 10 mg per day have a strong implication among people at high risk of AMD or with early signs and symptoms of AMD.
In other words, dietary sources of carotenoids can prevent the onset of progression of age-related macular degeneration even with people at a higher risk of AMD.
In order to confirm the effect of lutein and zeaxanthin (L/Z) activity in the protection of AMD, the University of Melbourne. conducted an experiment containing 254 who were identified with early age-related macular degeneration (AMD).
Intakes of L/Z and fatty acids were estimated from food frequency questionnaires.
According to the results, researchers surprisingly found that
* L/Z has a strong implication in reducing the risk of AMD in a dose-dependent manner.
* Increasing L/Z intake was associated with the progression of AMD. Too much of a good thing (L/Z) might be harmful.
After taking other factors into account, researchers wrote, " It is possible that in this study participants adopted a more healthy diet, having been aware of their AMD status at the beginning of the study. This healthy diet was then reflected in the dietary questionnaire completed at the end of the study".
And, " However, this explanation may not adequately explain why those whose AMD had progressed, on the basis of fundus signs and not symptoms such as visual acuity decline, adopted a healthier lifestyle more aggressively than those without progression".
Based on the findings, daily intake of L/Z intake up to 10 mg per day was associated with decreasing the risk of AMD
Taken together, carotenoids processed abundantly L/Z may be considered a remedy for the prevention and treatment of age-related macular degeneration, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection by Eisenhauer B1, Natoli S2, Liew G3, Flood VM. (PubMed)
(2) Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration by Robman L1, Vu H, Hodge A, Tikellis G, Dimitrov P, McCarty C, Guymer R. (PubMed)
(3) Smoking and Age-Related Macular Degeneration: Review and Update by Sara Velilla, 1, 2 José Javier García-Medina, 3 , 4 , 5 Alfredo García-Layana, 2 , 6Rosa Dolz-Marco, 5 , 7 Sheila Pons-Vázquez, 5 M. Dolores Pinazo-Durán, 2 , 5 , 8Francisco Gómez-Ulla, 2 , 9 , 10 J. Fernando Arévalo, 11 , 12 Manuel Díaz-Llopis, 2 , 7 , 8 andRoberto Gallego-Pinazo. (PMC)
Coffee Exerts A Protective Effect Against the Risk of #Depression, According to Clinical Trials
Kyle J. Norton
Epidemiological studies do not agree that coffee and coffee caffeine have a positive effect on reduced depression, a review literature study suggested.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
Depression is a normal neuro response as part of our daily lives such as the loss of s job, the death of a loved one, and illness.
Over 30 million Americans suffer from depression and the amounts are increasing at an alarming rate.
According to the University of Naples Federico II, over 2 decades, many studies addressed the concerns that coffee intake may have an implication of incidence of depression, but several phytochemical studies indicated a different outcome as caffeine and certain major phytoconstituents exhibited antidepressant effects through multiple molecular mechanisms.
Dr. Tenore GC, the lead researcher said, "Coffee can be considered a drink which has different positive effects on human health such as cardioprotective, neuroprotective, hepatoprotective, nephroprotective, etc. However, heavy coffee consumption may be related to some unpleasant symptoms, mainly anxiety, headache, increased blood pressure, nausea, and restlessness".
Contrastively, caffeine in coffee showed a strong inverse association in cases of postpartum depression and comorbid panic disorder.
Other researchers in the search for the efficacy of coffee and the risk of depression through databases from PubMed and PsychINFO insisted that although literature data are conflicting, caffeine found in coffee indicated a significantly reduced effect on symptoms of clinical depression.
Additionally, in a cross-sectional study of 10,177 Korean individuals aged 20-97 years the prevalence of self-reported depression of 14.0%, and of self-reported clinical depression of 3.7%. participated in the fifth Korean National Health and Nutrition Examination Survey. to determine the effect of the consumption of coffee and the risk of depression, after adjusting to other factors, the returned survey from patients can be cataloged into the following
For general depression
1. The relative odd ratio of patients drinking less than one cup/week was 0.84
2. The relative odd ratio of patients drinking one to six cups/week was 0.63
3. The relative odd ratio of patients drinking for one cup/day was 0.69
4. The relative odd ratio of patients drinking for two cups/day was 0.54
5. The relative odd ratio of patients drinking for three or more cups/day was .58
For clinical depression, similar observations also have been recorded
1. The relative odd ratio of patients drinking less than one cup/week was 1.00
2. The relative odd ratio of patients drinking one to six cups/week was 0.51
3. The relative odd ratio of patients drinking for one cup/day was 0.57
4. The relative odd ratio of patients drinking for two cups/day was 0.57
5. The relative odd ratio of patients drinking for three or more cups/day was 0.41
The findings although not linearly, coffee and coffee caffeine intake expressed a protective effect in the ameliorated risk of depression.
Taken together, there is no doubt that coffee and coffee caffeine intake daily and regularly have a profound effect on depression but further cohost large sample-sized studies are necessary to find out other factors that may contribute to either outcome.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Coffee and Depression: A Short Review of Literature by Tenore GC1, Daglia M, Orlando V, D'Urso E, Saadat SH, Novellino E, Nabavi SF, Nabavi SM.(PubMed)
(2) [Coffee consumption in depressive disorders: it's not one size fits all].[Article in Italian] by Rusconi AC, Valeriani G, Carluccio GM, Majorana M, Carlone C, Raimondo P, Ripà S, Marino P, Coccanari de Fornari MA, Biondi M.(PubMed)
Epidemiological studies do not agree that coffee and coffee caffeine have a positive effect on reduced depression, a review literature study suggested.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
Depression is a normal neuro response as part of our daily lives such as the loss of s job, the death of a loved one, and illness.
Over 30 million Americans suffer from depression and the amounts are increasing at an alarming rate.
According to the University of Naples Federico II, over 2 decades, many studies addressed the concerns that coffee intake may have an implication of incidence of depression, but several phytochemical studies indicated a different outcome as caffeine and certain major phytoconstituents exhibited antidepressant effects through multiple molecular mechanisms.
Dr. Tenore GC, the lead researcher said, "Coffee can be considered a drink which has different positive effects on human health such as cardioprotective, neuroprotective, hepatoprotective, nephroprotective, etc. However, heavy coffee consumption may be related to some unpleasant symptoms, mainly anxiety, headache, increased blood pressure, nausea, and restlessness".
Contrastively, caffeine in coffee showed a strong inverse association in cases of postpartum depression and comorbid panic disorder.
Other researchers in the search for the efficacy of coffee and the risk of depression through databases from PubMed and PsychINFO insisted that although literature data are conflicting, caffeine found in coffee indicated a significantly reduced effect on symptoms of clinical depression.
Additionally, in a cross-sectional study of 10,177 Korean individuals aged 20-97 years the prevalence of self-reported depression of 14.0%, and of self-reported clinical depression of 3.7%. participated in the fifth Korean National Health and Nutrition Examination Survey. to determine the effect of the consumption of coffee and the risk of depression, after adjusting to other factors, the returned survey from patients can be cataloged into the following
For general depression
1. The relative odd ratio of patients drinking less than one cup/week was 0.84
2. The relative odd ratio of patients drinking one to six cups/week was 0.63
3. The relative odd ratio of patients drinking for one cup/day was 0.69
4. The relative odd ratio of patients drinking for two cups/day was 0.54
5. The relative odd ratio of patients drinking for three or more cups/day was .58
For clinical depression, similar observations also have been recorded
1. The relative odd ratio of patients drinking less than one cup/week was 1.00
2. The relative odd ratio of patients drinking one to six cups/week was 0.51
3. The relative odd ratio of patients drinking for one cup/day was 0.57
4. The relative odd ratio of patients drinking for two cups/day was 0.57
5. The relative odd ratio of patients drinking for three or more cups/day was 0.41
The findings although not linearly, coffee and coffee caffeine intake expressed a protective effect in the ameliorated risk of depression.
Taken together, there is no doubt that coffee and coffee caffeine intake daily and regularly have a profound effect on depression but further cohost large sample-sized studies are necessary to find out other factors that may contribute to either outcome.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Coffee and Depression: A Short Review of Literature by Tenore GC1, Daglia M, Orlando V, D'Urso E, Saadat SH, Novellino E, Nabavi SF, Nabavi SM.(PubMed)
(2) [Coffee consumption in depressive disorders: it's not one size fits all].[Article in Italian] by Rusconi AC, Valeriani G, Carluccio GM, Majorana M, Carlone C, Raimondo P, Ripà S, Marino P, Coccanari de Fornari MA, Biondi M.(PubMed)
#Ginger Exerts a Modulatory Effects on Septic Responses and Survival Rate, Scientists Show
Kyle J. Norton
Sepsis is a medical condition caused by the body's over-response to infection by releasing a large number of chemicals into the bloodstream, leading to a chemical imbalance that can damage multiple organ systems.
The most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen), and pelvis.
The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allows the inflammation to spread to the entire body.
Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.
The risk factors of sepsis include any medical conditions that can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy, and diabetes.
The most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, and problems breathing. abnormal heart functions, fall in blood pressure and fall in body temperature. unconsciousness.
If your child or you experience some of the above symptoms, please call the emergency services right away.
Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.
Dr. A S Kolyva, the lead scientist said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".
And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".
These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiate the onset of sepsis but also increase the potential negative impact on the outcome.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkenone isolated from ginger in various pharmacological activities, including sepsis.
Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.
The modulation of ginger was attributed to the suppression of the production of inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.
High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells that line the interior surface of blood vessels and lymphatic vessel integrity.
Furthermore, the injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.
Moreover, in vivo, ginger inhibited lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.
In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.
Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.
Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.
Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".
Taken together, ginger may be considered a functional remedy for the treatment of sepsis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).
Sepsis is a medical condition caused by the body's over-response to infection by releasing a large number of chemicals into the bloodstream, leading to a chemical imbalance that can damage multiple organ systems.
The most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen), and pelvis.
The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allows the inflammation to spread to the entire body.
Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.
The risk factors of sepsis include any medical conditions that can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy, and diabetes.
The most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, and problems breathing. abnormal heart functions, fall in blood pressure and fall in body temperature. unconsciousness.
If your child or you experience some of the above symptoms, please call the emergency services right away.
Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.
Dr. A S Kolyva, the lead scientist said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".
And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".
These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiate the onset of sepsis but also increase the potential negative impact on the outcome.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkenone isolated from ginger in various pharmacological activities, including sepsis.
Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.
The modulation of ginger was attributed to the suppression of the production of inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.
High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells that line the interior surface of blood vessels and lymphatic vessel integrity.
Furthermore, the injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.
Moreover, in vivo, ginger inhibited lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.
In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.
Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.
Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.
Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".
Taken together, ginger may be considered a functional remedy for the treatment of sepsis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).
#Healthy Food #BroccoliSprout #SFN Inhibit Markers of Inflammation Associated with Infection of Influenza Viruses, Researchers Say
Kyle J. Norton
Influenza also known as "the flu", is an infectious disease caused by an influenza virus.
In other words, flu (influenza) is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza virus) that can lead to symptoms of chills, fever, sore throat, muscle pains, severe headache, coughing, etc.
There are 3 types of flu influenza: A, B, and C. The influenza viruses A and B are considered seasonal flu that causes sniffling, aching, coughing, running and stuffy nose, and fever to over 20% of the general population.
Influenza virus type C tends to cause mild upper respiratory infections, similar to those of colds.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune systems such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, and chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to changes in the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
The most common H and N subtypes are influenza A which has been mutated to affect the combination of human, swine, and bird flu viruses, including
* H1N1 - Swine Flu
H1N1 normally is only transmitted among pigs. However, as of today, H1N1 has become the first flu pandemic in the world that causes respiratory illness.
* H5N1 - Bird Flu
H5N1 is the strain of influenza known as bird or avian flu. Before, it was transmitted between birds, but today, it can be passed from bird to human. The strain is dangerous to humans with high death rates.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of viral diseases, researchers examined the effects of broccoli sprout homogenates (BSH) on nasal cytokines, virus replication, and Nrf2-dependent enzyme expression in smokers and nonsmokers.
The randomized, double-blind, placebo-controlled trial included healthy young adult smokers and nonsmokers who ingested BSH or placebo (alfalfa sprout homogenate) for 4 days, designated Days -1, 0, 1, 2. and on day 0 they received standard vaccine dose of live attenuated influenza virus (LAIV) intranasally.
According to the tested analysis,
* In the area under curve analyses, post-LAIV IL-6 responses (P = 0.03) and influenza sequences (P = 0.01) were significantly reduced in NLF from BSH-treated smokers.
* However, In nonsmokers, a similar trend for reduction in virus quantity with BSH did not reach statistical significance.
In other words, in smokers, short-term ingestion of broccoli sprout homogenates appears to significantly reduce some virus-induced markers of inflammation, and virus quantity compared to less significant in non-smokers.
Based on the results, researchers wrote, " Nutritional antioxidant interventions have promise as a safe, low-cost strategy for reducing influenza risk among smokers and other at-risk populations".
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".
In other words, SFN protects the integrity of the neurons against neuron damage through its anti-neuroinflammatory and neuroprotective activities.
Taken together, broccoli sprouts may be considered supplements for the prevention of influenza, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study by Noah TL1, Zhang H2, Zhou H2, Glista-Baker E3, Müller L4, Bauer RN5, Meyer M6, Murphy PC7, Jones S3, Letang B8, Robinette C3, Jaspers I. (PubMed)
Influenza also known as "the flu", is an infectious disease caused by an influenza virus.
In other words, flu (influenza) is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza virus) that can lead to symptoms of chills, fever, sore throat, muscle pains, severe headache, coughing, etc.
There are 3 types of flu influenza: A, B, and C. The influenza viruses A and B are considered seasonal flu that causes sniffling, aching, coughing, running and stuffy nose, and fever to over 20% of the general population.
Influenza virus type C tends to cause mild upper respiratory infections, similar to those of colds.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune systems such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, and chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to changes in the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
The most common H and N subtypes are influenza A which has been mutated to affect the combination of human, swine, and bird flu viruses, including
* H1N1 - Swine Flu
H1N1 normally is only transmitted among pigs. However, as of today, H1N1 has become the first flu pandemic in the world that causes respiratory illness.
* H5N1 - Bird Flu
H5N1 is the strain of influenza known as bird or avian flu. Before, it was transmitted between birds, but today, it can be passed from bird to human. The strain is dangerous to humans with high death rates.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of viral diseases, researchers examined the effects of broccoli sprout homogenates (BSH) on nasal cytokines, virus replication, and Nrf2-dependent enzyme expression in smokers and nonsmokers.
The randomized, double-blind, placebo-controlled trial included healthy young adult smokers and nonsmokers who ingested BSH or placebo (alfalfa sprout homogenate) for 4 days, designated Days -1, 0, 1, 2. and on day 0 they received standard vaccine dose of live attenuated influenza virus (LAIV) intranasally.
According to the tested analysis,
* In the area under curve analyses, post-LAIV IL-6 responses (P = 0.03) and influenza sequences (P = 0.01) were significantly reduced in NLF from BSH-treated smokers.
* However, In nonsmokers, a similar trend for reduction in virus quantity with BSH did not reach statistical significance.
In other words, in smokers, short-term ingestion of broccoli sprout homogenates appears to significantly reduce some virus-induced markers of inflammation, and virus quantity compared to less significant in non-smokers.
Based on the results, researchers wrote, " Nutritional antioxidant interventions have promise as a safe, low-cost strategy for reducing influenza risk among smokers and other at-risk populations".
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".
In other words, SFN protects the integrity of the neurons against neuron damage through its anti-neuroinflammatory and neuroprotective activities.
Taken together, broccoli sprouts may be considered supplements for the prevention of influenza, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study by Noah TL1, Zhang H2, Zhou H2, Glista-Baker E3, Müller L4, Bauer RN5, Meyer M6, Murphy PC7, Jones S3, Letang B8, Robinette C3, Jaspers I. (PubMed)
A Mixture of Low Concentrations of #I3C (50 μM) Plus #Silibinin (50 μM) Inhibits Lung Cancer Cell Growth and Promotes Apoptosis, Researchers Say
Kyle J. Norton
Some scientists found that indole-3-carbinol, an organic compound found in cruciferous vegetables, may potentially reduce the risk and treatment of lung cancer.
Lung cancer is a class of chronic and medical disease caused by irregular cell growth originating from the inner lining of the lung tissue due to DNA alternation.
At the advanced stage after colonizing most parts of the lung, the cancerous cells can travel from the primary site to infect other healthy tissue and organs a distance away.
In the US, lung cancer is the leading cause of cancer deaths, causing 158,683 deaths, including 88,329 men and 70,354 women, according to the 2007 statistics.
Researchers do not the exact causes of lung cancer. As of today, no one knows why people with similar health conditions, family history, and race, some are susceptible to the early onset of the disease while others do not.
Some researchers suggested genetic mutation and long-term cigarette smoking are 2 major risk factors associated with the alternative of lung cell DNA.
Indeed, according to the statistics, approximately 8% of lung cancers are inherited or occur due to a genetic predisposition.
Dr. Ahmed El-Telbany, the lead scientist in the study "Cancer Genes in Lung Cancer. Racial Disparities: Are There Any?" said, "Mutational analysis and genomics profiling in recent years have advanced the field of lung cancer genetics/genomics significantly. It is becoming more accepted now that the identification of genomic alterations in lung cancer can impact therapeutics, especially when the alterations represent “oncogenic drivers” in the processes of tumorigenesis and progression" and
"The genes which are associated with lung cancer risk include EGFR, KRAS, MET, LKB1, BRAF, PIK3CA, ALK, RET, and ROS1".
Genetic mutation inherited from the parents is a result of an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase a person's chance of developing lung cancer.
However, not all people who carry mutated lung cancer genes will develop lung cancer.
Cigarette smoking in the risk of lung cancer, researchers believe cigarettes contain high amounts of cancer-causing substances (carcinogens), when inhaled, the cigarette smoke carries the chemical toxins to the lung cells directly, and prolonged periods of exposure to such chemicals can alternate lung cell DNA, leading to the early onset of lung cancer.
The joint study to examine the impact of smoking on risks of the major cell types of lung cancer led by the Institute of Ruhr Universität Bochum (IPA) included 13,169 cases and 16,010 controls from Europe and Canada suggested
* Squamous cell carcinoma (SqCC) predominated in male smokers.
* The ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for Adenocarcinoma (AdCa)
* Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% CI 74.8-143.2) for SqCC, 111.3 (95% CI 69.8-177.5) for small cell lung cancer (SCLC), and 21.9 (95% CI 16.6-29.0) for AdCa.
These results surely reconfirmed the epidemiological studies' suggestion, that long-term use of cigarettes is associated with a substantially increased risk of lung cancer regardless of gender.
Indole-3-carbinol is a phytochemical in the class of Indoles found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
With an aim to find the natural ingredient for the treatment of lung cancer without inducing any adverse effects, the University of Minnesota conducted a study to test the chemopreventive efficacy of indole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables, to inhibit tobacco carcinogen-induced lung adenocarcinoma in A/J mice.
Before the infection of indole-3-carbinol (I3C), the tested mice were given a post-initiation or progression protocol.
Post-initiation administration of I3C decreased the multiplicity of surface tumors as well as all forms of histopathological lesions, including adenocarcinoma.
Further analysis of the effect of indole-3-carbinol (I3C), in the A549 lung adenocarcinoma cell line, researchers indicated that the lung cancer-preventive effects of I3C are mediated, at least in part, via modulation of the receptor tyrosine kinase/PI3K/Akt signaling pathway in the inhibition of cell growth and proliferation.
However, the administration of the compound during tumor progression failed to decrease the multiplicity of surface tumors and early forms of microscopic lesions but reduced the frequency of adenocarcinoma.
In vivo, administration of a mixture of low concentrations of I3C (50 μM) plus silibinin (50 μM) for 72 h also displayed significant inhibition of cell growth through the expression of the extracellular signal-regulated kinase (ERK) and Akt activation in the induction of apoptosis of A549 and H460 lung cancer cells.
Moreover, in the examination, the effects of indole-3-carbinol (I3C), in a mixture of NNK plus BaP (2 micromols each), administered by gavage as eight biweekly doses caused 21.1 +/- 5.2 lung tumors in a mouse model.
* Lung cancer-induced mice given diets containing I3C at 1, 10, 30, 71, and 112 micromol/g, beginning at 50% in the carcinogen treatment phase, had 17.9 +/- 6.1, 10.4 +/- 3.7, 9.8 +/- 5.1, 5.2 +/- 4.0, and 2.5 +/- 2.4 lung tumors per mouse, corresponding to reductions by 15%, 51%, 53%, 75%, and 88%, respectively.
* I3C was significantly effective at the lowest dose level (1 micromol I3C/g diet).
* Administration of I3C (112 micromols/g diet) beginning 1 week after the last dose of the carcinogen significantly reduced lung cancer induced by NNK plus BaP by 74%.
* I3C inhibited the lung cancer progression partly through antiproliferative and apoptotic activity.
Dr. Kassie F, the lead scientist, at the final phase of the experiment, said, "The efficacy of I3C in the prevention of tobacco carcinogen-induced lung tumorigenesis in A/J mice and provide a basis for future evaluation of this compound in clinical trials as a chemopreventive agent for current and former smokers".
Taken together, phytochemical Indole-3-carbinol may be considered a functional bioactive compound for the prevention of lung cancer and a secondary therapy combined with the primary medicine for the treatment of lung cancer, depending on the further data collection of the large sample size and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis by Qian X1, Melkamu T, Upadhyaya P, Kassie F.(PubMed)
(2) Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol by Kassie F1, Matise I, Negia M, Upadhyaya P, Hecht SS.(PubMed)
(3) Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice by Dagne A1, Melkamu T, Schutten MM, Qian X, Upadhyaya P, Luo X, Kassie F.(PubMed)
(4) Cancer Genes in Lung Cancer Racial Disparities: Are There Any? by Ahmed El-Telbany1,2 and Patrick C. Ma. (PMC)
Some scientists found that indole-3-carbinol, an organic compound found in cruciferous vegetables, may potentially reduce the risk and treatment of lung cancer.
Lung cancer is a class of chronic and medical disease caused by irregular cell growth originating from the inner lining of the lung tissue due to DNA alternation.
At the advanced stage after colonizing most parts of the lung, the cancerous cells can travel from the primary site to infect other healthy tissue and organs a distance away.
In the US, lung cancer is the leading cause of cancer deaths, causing 158,683 deaths, including 88,329 men and 70,354 women, according to the 2007 statistics.
Researchers do not the exact causes of lung cancer. As of today, no one knows why people with similar health conditions, family history, and race, some are susceptible to the early onset of the disease while others do not.
Some researchers suggested genetic mutation and long-term cigarette smoking are 2 major risk factors associated with the alternative of lung cell DNA.
Indeed, according to the statistics, approximately 8% of lung cancers are inherited or occur due to a genetic predisposition.
Dr. Ahmed El-Telbany, the lead scientist in the study "Cancer Genes in Lung Cancer. Racial Disparities: Are There Any?" said, "Mutational analysis and genomics profiling in recent years have advanced the field of lung cancer genetics/genomics significantly. It is becoming more accepted now that the identification of genomic alterations in lung cancer can impact therapeutics, especially when the alterations represent “oncogenic drivers” in the processes of tumorigenesis and progression" and
"The genes which are associated with lung cancer risk include EGFR, KRAS, MET, LKB1, BRAF, PIK3CA, ALK, RET, and ROS1".
Genetic mutation inherited from the parents is a result of an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase a person's chance of developing lung cancer.
However, not all people who carry mutated lung cancer genes will develop lung cancer.
Cigarette smoking in the risk of lung cancer, researchers believe cigarettes contain high amounts of cancer-causing substances (carcinogens), when inhaled, the cigarette smoke carries the chemical toxins to the lung cells directly, and prolonged periods of exposure to such chemicals can alternate lung cell DNA, leading to the early onset of lung cancer.
The joint study to examine the impact of smoking on risks of the major cell types of lung cancer led by the Institute of Ruhr Universität Bochum (IPA) included 13,169 cases and 16,010 controls from Europe and Canada suggested
* Squamous cell carcinoma (SqCC) predominated in male smokers.
* The ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for Adenocarcinoma (AdCa)
* Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% CI 74.8-143.2) for SqCC, 111.3 (95% CI 69.8-177.5) for small cell lung cancer (SCLC), and 21.9 (95% CI 16.6-29.0) for AdCa.
These results surely reconfirmed the epidemiological studies' suggestion, that long-term use of cigarettes is associated with a substantially increased risk of lung cancer regardless of gender.
Indole-3-carbinol is a phytochemical in the class of Indoles found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
With an aim to find the natural ingredient for the treatment of lung cancer without inducing any adverse effects, the University of Minnesota conducted a study to test the chemopreventive efficacy of indole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables, to inhibit tobacco carcinogen-induced lung adenocarcinoma in A/J mice.
Before the infection of indole-3-carbinol (I3C), the tested mice were given a post-initiation or progression protocol.
Post-initiation administration of I3C decreased the multiplicity of surface tumors as well as all forms of histopathological lesions, including adenocarcinoma.
Further analysis of the effect of indole-3-carbinol (I3C), in the A549 lung adenocarcinoma cell line, researchers indicated that the lung cancer-preventive effects of I3C are mediated, at least in part, via modulation of the receptor tyrosine kinase/PI3K/Akt signaling pathway in the inhibition of cell growth and proliferation.
However, the administration of the compound during tumor progression failed to decrease the multiplicity of surface tumors and early forms of microscopic lesions but reduced the frequency of adenocarcinoma.
In vivo, administration of a mixture of low concentrations of I3C (50 μM) plus silibinin (50 μM) for 72 h also displayed significant inhibition of cell growth through the expression of the extracellular signal-regulated kinase (ERK) and Akt activation in the induction of apoptosis of A549 and H460 lung cancer cells.
Moreover, in the examination, the effects of indole-3-carbinol (I3C), in a mixture of NNK plus BaP (2 micromols each), administered by gavage as eight biweekly doses caused 21.1 +/- 5.2 lung tumors in a mouse model.
* Lung cancer-induced mice given diets containing I3C at 1, 10, 30, 71, and 112 micromol/g, beginning at 50% in the carcinogen treatment phase, had 17.9 +/- 6.1, 10.4 +/- 3.7, 9.8 +/- 5.1, 5.2 +/- 4.0, and 2.5 +/- 2.4 lung tumors per mouse, corresponding to reductions by 15%, 51%, 53%, 75%, and 88%, respectively.
* I3C was significantly effective at the lowest dose level (1 micromol I3C/g diet).
* Administration of I3C (112 micromols/g diet) beginning 1 week after the last dose of the carcinogen significantly reduced lung cancer induced by NNK plus BaP by 74%.
* I3C inhibited the lung cancer progression partly through antiproliferative and apoptotic activity.
Dr. Kassie F, the lead scientist, at the final phase of the experiment, said, "The efficacy of I3C in the prevention of tobacco carcinogen-induced lung tumorigenesis in A/J mice and provide a basis for future evaluation of this compound in clinical trials as a chemopreventive agent for current and former smokers".
Taken together, phytochemical Indole-3-carbinol may be considered a functional bioactive compound for the prevention of lung cancer and a secondary therapy combined with the primary medicine for the treatment of lung cancer, depending on the further data collection of the large sample size and multi-center human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis by Qian X1, Melkamu T, Upadhyaya P, Kassie F.(PubMed)
(2) Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol by Kassie F1, Matise I, Negia M, Upadhyaya P, Hecht SS.(PubMed)
(3) Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice by Dagne A1, Melkamu T, Schutten MM, Qian X, Upadhyaya P, Luo X, Kassie F.(PubMed)
(4) Cancer Genes in Lung Cancer Racial Disparities: Are There Any? by Ahmed El-Telbany1,2 and Patrick C. Ma. (PMC)
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