Kyle J. Norton
Garlic (Allium sativum) may have a potential effect in the prevention and treatment of cancers by gobbling up cancer cells before they can proliferate to the invasive tumor, some studies suggested.
Cancers are a class of chronic diseases characterized by uncontrollable cells grown in tissue in the body.
At the later stage, the cancerous cells can infect other healthy cells and tissue far away from the original site by traveling through blood and lymph.
The diseases are the second cause of death in the US.
According to statistics, between 2011-2015, the National Cancer Institute, 440 per 100,000 adults are diagnosed with cancers, inducing 163.5 per 100,000 death
Depending on the type of cancer, patients may experience certain general and specific symptoms.
DNA alternation caused by an inherited gene mutation in the induction of abnormal cell proliferation is the major cause of cancers.
The National Cancer Institute suggested that age, excessive alcohol consumption, unhealthy diet and lifestyle, smoking, radiation, viruses, carcinogens, obesity,... and chronic inflammation, are also considered some major risk factors that can cause cancers. (As these factors are accumulated through many studies which all point to a similar association between a potential risk factor and an increased risk of cancer).
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.
The pungent herb has been used popularly in traditional and Chinese medicine for treating common cold and flu, blood pressure cholesterol levels,..... and as a natural antibiotic.
Garlic appears to be generally safe although some people may suffer mild allergic reactions.
A recent study led by author Dr. Oommen S indicated that allicin, the main ingredient found in garlic induces the formation of apoptotic bodies, nuclear condensation, and a typical DNA ladder in cancer cells, causing cell death.
Researchers in the study of the ingredient allicin also showed that the phytochemical is capable of inducing an increase in the rate of apoptosis by obstructing the expression of the cell cycle division and pro-inflammation.
On cancer HL60 and U937 cell lines, allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway by involving the activation of the mitochondrial apoptotic pathway through promoted GSH depletion and changes in the intracellular redox status.
In the research of the function of 20 compounds from garlic, researchers at the Kerala Agricultural University, Kerala, suggested that garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers.
Other compounds found in garlic such as organosulfur, its extract, and phyto-compounds also suppressed cancer cell proliferation and induced cell cycle arrest.
Therefore, people who are at higher risk of the disease may consider adding a portion of garlic whole food into their diet for preventive measures.
However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells by Oommen S1, Anto RJ, Srinivas G, Karunagaran D.(PubMed)
(2) Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA by Park SY1, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S.(PubMed)
(3) Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells by Miron T1, Wilchek M, Sharp A, Nakagawa Y, Naoi M, Nozawa Y, Akao Y.(PubMed)
(4) Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study by Roy N1, Davis S, Narayanankutty A, Nazeem P, Babu T, Abida P, Valsala P, Raghavamenon AC.(PubMed)
(5) Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice by Jiang X1, Zhu X1, Huang W1, Xu H1, Zhao Z2, Li S1, Li S3, Cai J3, Cao J3.(PubMed)
(6) Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis by Kim WT1, Seo SP2, Byun YJ1, Kang HW1, Kim YJ1, Lee SC1, Jeong P1, Seo Y3, Choe SY3, Kim DJ4, Kim SK5, Moon SK6, Choi YH7, Lee GT8, Kim IY8, Yun SJ1, Kim WJ1.(PubMed)
(7) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC3.(PubMed)
Wednesday, 20 September 2023
#CruciferousVegetables Decrease the Risk of Kidney Cancer, Reserachers Suggest
Kyle J. Norton
The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.
The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, and blood pressure, maintains acid-base balance, and produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules.
In the urinary system, kidneys reabsorb some necessary substances back into the blood, while waste, such as urea and ammonium is deposited into the pelvis and then into the ureter to the bladder for secretion.
Kidney Cancer is a medical condition characterized by irregular cell growth in the tissue of the kidneys.
At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spreads to the lung is called kidney cancer with lung metastases.
At the very early stage of the kidney, cancerous tumors are localized on the surface of the kidneys.
The most common type of kidney cancer is renal cell cancer.
The causes of kidney cancer are unknown. Some researchers suggested that genetic mutation, cigarette smoking, obesity, family history,..... and exposure to chemicals, such as asbestos and benzene are all associated with increased risk of kidney cancer.
Kidney cancer affects only 2% of the general population. Approximately 14 percent of the US population suffers some form of chronic kidney disease (CKD), including 661,000 cases of kidney failure.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for reducing the risk of chronic diseases, researchers examined the effects of cruciferous vegetable consumption in the risk of renal cell carcinoma.
The meta-analysis included 3 cohort and 7 case-control studies retrieved via both computerized searches and review of references.
According to the summary of the calculation of the relative risks (RRs) with 95% confidence interval (CI) for the highest vs. the lowest consumption of cruciferous vegetables,
in cruciferous vegetable consumption group (RR = 0.73; 95% CI, 0.63-0.83) and a subgroup of case-control studies (RR = 0.69; 95% CI, 0.60-0.78), compared to statistically insignificant in cohort studies (RR = 0.96; 95% CI, 0.71-1.21).
No heterogeneity and publication bias was detected across studies.
In other words, the meta-analysis supported cruciferous vegetable consumption for decreasing the risk of renal cell carcinoma.
However, because of the limited number of studies, researchers said, "further well-designed prospective studies and researches need to be conducted to better clarify the protective effect of cruciferous vegetables on renal cell carcinoma and potential mechanism".
Taken together, cruciferous vegetables may be considered functional remedies for the prevention of kidney cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous vegetable consumption and risk of renal cell carcinoma: a meta-analysis by Liu B1, Mao Q, Wang X, Zhou F, Luo J, Wang C, Lin Y, Zheng X, Xie L. (PubMed)
The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.
The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, and blood pressure, maintains acid-base balance, and produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules.
In the urinary system, kidneys reabsorb some necessary substances back into the blood, while waste, such as urea and ammonium is deposited into the pelvis and then into the ureter to the bladder for secretion.
Kidney Cancer is a medical condition characterized by irregular cell growth in the tissue of the kidneys.
At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spreads to the lung is called kidney cancer with lung metastases.
At the very early stage of the kidney, cancerous tumors are localized on the surface of the kidneys.
The most common type of kidney cancer is renal cell cancer.
The causes of kidney cancer are unknown. Some researchers suggested that genetic mutation, cigarette smoking, obesity, family history,..... and exposure to chemicals, such as asbestos and benzene are all associated with increased risk of kidney cancer.
Kidney cancer affects only 2% of the general population. Approximately 14 percent of the US population suffers some form of chronic kidney disease (CKD), including 661,000 cases of kidney failure.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for reducing the risk of chronic diseases, researchers examined the effects of cruciferous vegetable consumption in the risk of renal cell carcinoma.
The meta-analysis included 3 cohort and 7 case-control studies retrieved via both computerized searches and review of references.
According to the summary of the calculation of the relative risks (RRs) with 95% confidence interval (CI) for the highest vs. the lowest consumption of cruciferous vegetables,
in cruciferous vegetable consumption group (RR = 0.73; 95% CI, 0.63-0.83) and a subgroup of case-control studies (RR = 0.69; 95% CI, 0.60-0.78), compared to statistically insignificant in cohort studies (RR = 0.96; 95% CI, 0.71-1.21).
No heterogeneity and publication bias was detected across studies.
In other words, the meta-analysis supported cruciferous vegetable consumption for decreasing the risk of renal cell carcinoma.
However, because of the limited number of studies, researchers said, "further well-designed prospective studies and researches need to be conducted to better clarify the protective effect of cruciferous vegetables on renal cell carcinoma and potential mechanism".
Taken together, cruciferous vegetables may be considered functional remedies for the prevention of kidney cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous vegetable consumption and risk of renal cell carcinoma: a meta-analysis by Liu B1, Mao Q, Wang X, Zhou F, Luo J, Wang C, Lin Y, Zheng X, Xie L. (PubMed)
#GreenTea EGCG Enhances #Antioxidant Status-Induced Neuroprotective Effect Against the Onset of #Dementia, Reserachers Reveal
Kyle J. Norton
Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people. About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
Green tea may be used as a functional food for the prevention of early-onset and treatment of dementia due to aging progression, a renowned institute study suggested
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome", according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the neutralization trick.
In the 5.7-year prospective cohort study, using a questionnaire, information on daily green tea consumption, and other lifestyle factors collected from elderly Japanese individuals aged 65 years or more, green tea consumption is associated with a reduced risk of dementia with an incidence of the occurrent rate of 8.7%.
Furthermore, in the intracerebroventricular (ICV) infusion of streptozotocin (STZ) animal model explicted chronic brain dysfunction involved long-term and progressive deficits in learning, memory, and cognitive behavior, along with a permanent and ongoing cerebral energy deficit, mice treated with green tea EGCG at a dose of 10mg/kg/day for 4 weeks, showed a significant improvement in reduced oxidative stress parameter against the production of inflammatory and free radical expression.
These inhibitions can be seen in the diminished AChE activity, glutathione peroxidase activity as well as NO metabolites, and reactive oxygen species contents
More importantly, the enhanced antioxidant status-induced neuroprotective effect is a result of EGCG injection in ameliorated inflammatory and free radical causes of cell death in the brain of treated mice.
Dr. Tomata Y, the lead author of the study said, "The lower risk of incident dementia was consistent even after selecting participants who did not have subjective memory complaints at the baseline."
More explicitly, in the finding of natural food for reverse or delay risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors involved in the development of dementia and late-life cognitive disorders, green tea with a high amount of caffeine stimulates the psychoactive effects in attenuated cognitive impairment/decline and dementia through heightened alertness and arousal and improvement of cognitive performance.
Promisingly, such results have been proposed by several cross-sectional and longitudinal population-based studies, particularly in patients with mild cognitive impairment and progression to dementia.
There is no doubt that green tea may be considered as a function of foods for reduced risk of early-onset and delayed progression of dementia, but longer follow-up periods are necessary before the use of green tea can open new ways for diet-related prevention and treatment of dementia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study by Tomata Y1, Sugiyama K2, Kaiho Y2, Honkura K2, Watanabe T2, Zhang S2, Sugawara Y2, Tsuji I2(PubMed)
(2) Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia by Biasibetti R1, Tramontina AC, Costa AP, Dutra MF, Quincozes-Santos A, Nardin P, Bernardi CL, Wartchow KM, Lunardi PS, Gonçalves CA.(PubMed)
(3) Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review by Panza F1, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G.(PubMed)
Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people. About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
Green tea may be used as a functional food for the prevention of early-onset and treatment of dementia due to aging progression, a renowned institute study suggested
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome", according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the neutralization trick.
In the 5.7-year prospective cohort study, using a questionnaire, information on daily green tea consumption, and other lifestyle factors collected from elderly Japanese individuals aged 65 years or more, green tea consumption is associated with a reduced risk of dementia with an incidence of the occurrent rate of 8.7%.
Furthermore, in the intracerebroventricular (ICV) infusion of streptozotocin (STZ) animal model explicted chronic brain dysfunction involved long-term and progressive deficits in learning, memory, and cognitive behavior, along with a permanent and ongoing cerebral energy deficit, mice treated with green tea EGCG at a dose of 10mg/kg/day for 4 weeks, showed a significant improvement in reduced oxidative stress parameter against the production of inflammatory and free radical expression.
These inhibitions can be seen in the diminished AChE activity, glutathione peroxidase activity as well as NO metabolites, and reactive oxygen species contents
More importantly, the enhanced antioxidant status-induced neuroprotective effect is a result of EGCG injection in ameliorated inflammatory and free radical causes of cell death in the brain of treated mice.
Dr. Tomata Y, the lead author of the study said, "The lower risk of incident dementia was consistent even after selecting participants who did not have subjective memory complaints at the baseline."
More explicitly, in the finding of natural food for reverse or delay risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors involved in the development of dementia and late-life cognitive disorders, green tea with a high amount of caffeine stimulates the psychoactive effects in attenuated cognitive impairment/decline and dementia through heightened alertness and arousal and improvement of cognitive performance.
Promisingly, such results have been proposed by several cross-sectional and longitudinal population-based studies, particularly in patients with mild cognitive impairment and progression to dementia.
There is no doubt that green tea may be considered as a function of foods for reduced risk of early-onset and delayed progression of dementia, but longer follow-up periods are necessary before the use of green tea can open new ways for diet-related prevention and treatment of dementia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study by Tomata Y1, Sugiyama K2, Kaiho Y2, Honkura K2, Watanabe T2, Zhang S2, Sugawara Y2, Tsuji I2(PubMed)
(2) Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia by Biasibetti R1, Tramontina AC, Costa AP, Dutra MF, Quincozes-Santos A, Nardin P, Bernardi CL, Wartchow KM, Lunardi PS, Gonçalves CA.(PubMed)
(3) Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review by Panza F1, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G.(PubMed)
#ManukaHoney Protectes the Mucosa from Lesions and Preserved Gastric Mucosal Glycoprotein Against the Risk of Ulccers through Its Antioxidant Activity, Researchers Say
Kyle J. Norton
Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of diseases associated with oxidative stress, some scientists suggested.
Oxidative stress is a result of an imbalance in the ratio of free radicals and antioxidants in the body.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and
"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of an external source of antioxidants can assist in coping with this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.
Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
Honey-treated rats displayed a clinically significant decrease in the ulcer index by completely protecting the mucosa from lesions and preserved gastric mucosal glycoprotein.
Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.
These results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.
The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.
In other words, manuka honey inhibited the oxidative stress caused by overexpression of free radicals in the initiation of the onset of the ulcer.
Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcers in the rat model, researchers examined three different concentrations of honey applied to the tested rats.
During the experiment, researchers found that all 3 different concentrations display a strong effect in It reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.
In other words, manuka honey protects the rat stomach by inhibiting the overexpression of free radicals and pro-inflammatory cytokines inducing oxidative stress.
Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and non-enzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.
The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
The information collected strongly supports the use of manuka honey for the treatment of chronic ulcers and the preservation of mucosal glycoproteins.
Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
Taken all together, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.
Natural Medicine for Fattstudyver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)
Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of diseases associated with oxidative stress, some scientists suggested.
Oxidative stress is a result of an imbalance in the ratio of free radicals and antioxidants in the body.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and
"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of an external source of antioxidants can assist in coping with this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.
Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
Honey-treated rats displayed a clinically significant decrease in the ulcer index by completely protecting the mucosa from lesions and preserved gastric mucosal glycoprotein.
Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.
These results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.
The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.
In other words, manuka honey inhibited the oxidative stress caused by overexpression of free radicals in the initiation of the onset of the ulcer.
Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcers in the rat model, researchers examined three different concentrations of honey applied to the tested rats.
During the experiment, researchers found that all 3 different concentrations display a strong effect in It reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.
In other words, manuka honey protects the rat stomach by inhibiting the overexpression of free radicals and pro-inflammatory cytokines inducing oxidative stress.
Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and non-enzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.
The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
The information collected strongly supports the use of manuka honey for the treatment of chronic ulcers and the preservation of mucosal glycoproteins.
Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
Taken all together, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.
Natural Medicine for Fattstudyver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)
Tuesday, 19 September 2023
Coffee and #Coffee #Caffeine Inhibit Gene and Protein Expression Associated with a Reduced Risk of #Obesity, Researchers Say
Kyle J. Norton
In comparison to herbal medicine, food therapy even takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.
Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
Obesity is a medical condition of excess body fat accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity.
Good news for coffee lovers, bioactive components found in coffee may have a potential effect in reduced risk and management of obesity, a renowned institute study opinionated.
According to the joint study led by the National Taiwan University, the efficacy of coffee in reduced risk and management of obesity over the last 10 years of research, may be attributed to
1. decrease lipid accumulation in cells via the regulation of the cell cycle in fat tissue
2. improved fat metabolic formation in both protein and transcription factor expression
According to animal studies.
In humans, it is the result of decreased body weight and visceral fat stored within the abdominal cavity.
Furthermore, the study also expressed the importance of coffee intake in influencing the gut microbiota in obese animals and humans.
Additionally, in the evaluation of possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract (GCBE) in high-fat diet (HFD)-induced obese mice fed with only HFD or HFD with GCBE at 50, 100, and 200 mg/kg, respectively, researchers filed the following results
1. The treated group showed a significantly decreased body weight gain, and liver and white adipose tissue weights, but importantly intake of coffee also regulated adipose tissue lipolysis hormones in breaking down fat accumulation.
2. The efficacy of the treatment group in reduced obesity risk may also benefit the decreased mRNA expression levels of adipogenesis and adipocyte metabolism in both gene and protein expression.
3. Compared to other treated groups, GCBE-treated mice displayed a lower fat mass and relative body weight and decreased fat mass.
More importantly, in the review of papers from in vivo, ex vivo, and in vitro experimental studies in animals and human tissues as well as wide population-based epidemiological studies in the last 10 years, researchers at the joint study led by the South University School of Pharmacy said, " there is mounting evidence of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process".
Taken together, there is no doubt that coffee and coffee caffeine have a significant and potential effect in reducing risk and management of obesity, through various active biochemicals in dose deepening manner.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Coffee consumption, obesity, and type 2 diabetes: a mini-review by Santos RM1, Lima DR2.(PubMed)
In comparison to herbal medicine, food therapy even takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.
Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
Obesity is a medical condition of excess body fat accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity.
Good news for coffee lovers, bioactive components found in coffee may have a potential effect in reduced risk and management of obesity, a renowned institute study opinionated.
According to the joint study led by the National Taiwan University, the efficacy of coffee in reduced risk and management of obesity over the last 10 years of research, may be attributed to
1. decrease lipid accumulation in cells via the regulation of the cell cycle in fat tissue
2. improved fat metabolic formation in both protein and transcription factor expression
According to animal studies.
In humans, it is the result of decreased body weight and visceral fat stored within the abdominal cavity.
Furthermore, the study also expressed the importance of coffee intake in influencing the gut microbiota in obese animals and humans.
Additionally, in the evaluation of possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract (GCBE) in high-fat diet (HFD)-induced obese mice fed with only HFD or HFD with GCBE at 50, 100, and 200 mg/kg, respectively, researchers filed the following results
1. The treated group showed a significantly decreased body weight gain, and liver and white adipose tissue weights, but importantly intake of coffee also regulated adipose tissue lipolysis hormones in breaking down fat accumulation.
2. The efficacy of the treatment group in reduced obesity risk may also benefit the decreased mRNA expression levels of adipogenesis and adipocyte metabolism in both gene and protein expression.
3. Compared to other treated groups, GCBE-treated mice displayed a lower fat mass and relative body weight and decreased fat mass.
More importantly, in the review of papers from in vivo, ex vivo, and in vitro experimental studies in animals and human tissues as well as wide population-based epidemiological studies in the last 10 years, researchers at the joint study led by the South University School of Pharmacy said, " there is mounting evidence of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process".
Taken together, there is no doubt that coffee and coffee caffeine have a significant and potential effect in reducing risk and management of obesity, through various active biochemicals in dose deepening manner.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Coffee consumption, obesity, and type 2 diabetes: a mini-review by Santos RM1, Lima DR2.(PubMed)
#Herbal #Angelica Inhibits #IntrinsicPathway Associated with #Apoptosis of Neuroblastoma Cells, Reseachers Find
Kyle J. Norton
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting information.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are younger than 5.
Sadly, the five-year survival rate of cancer is less than 50%.
Most common symptoms totally depend on the area that has been affected
* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched, and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain, and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
On finding a natural ingredient for the prevention and treatment of brain cancer, scientists examined the effects of Angelica polymorpha Maxim root extract (APRE) cytotoxicity on neuroblastoma cells (NB).
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the final results of the experiment,
* APRE reduced cell viability in NB to a greater extent than in fibroblast cells.
* APRE could inhibit proteins and down-regulated pathways associated with cancer cell proliferation and survival.
* Furthermore, APRE promoted pro-apoptotic protein and inhibited the expression of proteins associated with anti-apoptosis.
* Moreover, APRE depolarized the mitochondria membrane potential and activation of caspase-3 associated with cell death in the SH-SY5Y cells.
Additional differentiation, researchers said, "APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved".
Taken together, herbal angelica may be considered a remedy for the treatment of neuroblastoma, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway by Rahman MA1, Bishayee K1, Huh SO. (PubMed)
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting information.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are younger than 5.
Sadly, the five-year survival rate of cancer is less than 50%.
Most common symptoms totally depend on the area that has been affected
* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched, and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain, and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
On finding a natural ingredient for the prevention and treatment of brain cancer, scientists examined the effects of Angelica polymorpha Maxim root extract (APRE) cytotoxicity on neuroblastoma cells (NB).
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the final results of the experiment,
* APRE reduced cell viability in NB to a greater extent than in fibroblast cells.
* APRE could inhibit proteins and down-regulated pathways associated with cancer cell proliferation and survival.
* Furthermore, APRE promoted pro-apoptotic protein and inhibited the expression of proteins associated with anti-apoptosis.
* Moreover, APRE depolarized the mitochondria membrane potential and activation of caspase-3 associated with cell death in the SH-SY5Y cells.
Additional differentiation, researchers said, "APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved".
Taken together, herbal angelica may be considered a remedy for the treatment of neuroblastoma, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway by Rahman MA1, Bishayee K1, Huh SO. (PubMed)
Chaste Tree Berry 's #Extract Inhibits Parameters Associated with Liver Damage and Injury, Scientists Suggest
Kyle J. Norton
Chaste tree berry is found to associate with reduced risk of liver damage and diseases through various mechanisms, the recent study suggested
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly the expression of levels of antioxidants in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.
According to Al-Hikmah University, the Hepatoprotective effects of chaste tree berries may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin levels which can also contribute to hepatoxicity.
Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".
Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase, and peroxidase levels in liver homogenate.
Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage
In fact, the extract displays an enormous hepaprotective effect similar to those of silymarin through enhancing the antioxidant mechanisms of its components, predominantly artemetin.
According to the Vinayaka Mission’s College of Pharmacy study, in the CCl4-induced hepatic injury in albino rats, vitex extracts not only comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damaged through injection of CCI4, to near normal in treated rats.
Taking together, there is no doubt that Chaste tree berries may process a protective effect in reducing the risk of harmful chemicals and drug-induced liver damage, but the injection of a large amount should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation, and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)
Chaste tree berry is found to associate with reduced risk of liver damage and diseases through various mechanisms, the recent study suggested
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly the expression of levels of antioxidants in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.
According to Al-Hikmah University, the Hepatoprotective effects of chaste tree berries may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin levels which can also contribute to hepatoxicity.
Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".
Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase, and peroxidase levels in liver homogenate.
Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage
In fact, the extract displays an enormous hepaprotective effect similar to those of silymarin through enhancing the antioxidant mechanisms of its components, predominantly artemetin.
According to the Vinayaka Mission’s College of Pharmacy study, in the CCl4-induced hepatic injury in albino rats, vitex extracts not only comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damaged through injection of CCI4, to near normal in treated rats.
Taking together, there is no doubt that Chaste tree berries may process a protective effect in reducing the risk of harmful chemicals and drug-induced liver damage, but the injection of a large amount should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation, and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)
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