#Pure #Allicin and Water #Extract of #Garlic Powder Inhibit the Proliferation of #EndometrialCancerCells, Researchers Find

Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of endometrial cancer with no side effects, according to studies.

The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particularly to the menstrual cycle.

Endometrial cancer is a late adulthood cancer characterized by the cell growth irregularly and uncontrollably in the endometrial tissue.

The cause of endometrial cancer is an alternation of call DNA in the endometrium.

Most cases of endometrial cancer start in the cells on the surface of the inner lining of the endometrium. After penetrating deeper into the organ tissue, the cancerous cell may induce secondary metastasis through lymph and blood.

Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer. The average age diagnosed with endometrial cancer is 60.

According to the statistics provided by the American Cancer Society, every year, approximately,
63,000 new cases of cancer of the body of the uterus (uterine body or corpus) will be diagnosed.
Endometrial cancer causes the death of 11,350 women,, every year.

The 5-year survival rate for women with uterine cancer is 81%. However, the 5 years mortality rate in black women is substantially higher, compared to white women.

The most common risk factors of endometrial cancer are associated with hormone change due to menopause, use of birth control pills, and tamoxifen pregnancy, ovarian tumors, and polycystic ovarian syndrome.

Some researchers suggested that obesity is one major cause of hormone change associated with the onset of endometrial cancer.

Dt. Evan L. Busch, the lead scientists analyzed the endometrial cancer risk factors, said, " Compared with not being obese, obesity increased the odds of having an ER-positive tumor at cut points of 0% to 20% [maximum OR, 2.92; 95% confidence interval (CI), 1.34–6.33] as well as the odds of having a PR-positive tumor at cut points of 70% to 90% (maximum OR, 2.53; 95% CI, 1.36–4.68)".

And, " Obesity may be associated with greater endometrial tumor expression of ER and PR. Adding either marker does not appear to improve mortality prediction beyond the standard predictors".

Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

With an aim to find the ingredients for the treatment of endometrial cancer, researchers determined whether pure allicin exhibits the antiproliferative effect reported for garlic in vitro models.

Treatment of allicin, but not its precursor alliin, inhibited the proliferation of human endometrial (Ishikawa) cancer cells (50% inhibitory concentration = 10-25 microM).

Furthermore, the pure allicin and water extract of garlic powder with equivalent allicin concentrations displayed a similar potency.

The result strongly suggested that allicin is responsible for the antiproliferative effect of the extract.

Allicin treatments inhibited the levels of antioxidants produced by the cancer cell line and the extent of the decrease in glutathione (GSH) levels correlated well (r = 0.75) with the growth-inhibitory activity of allicin.

However, the magnitude and kinetics of which significantly varied depending on the cancer cell type.


Dr. Hirsch K, the lead scientist said, allicin plays a major role in the antiproliferative effect of water-soluble garlic preparations and that this effect may be attributed to the ability of allicin to transiently deplete the intracellular GSH level.

Moreover, the treatment of allicin also induces cancer cell death through activating proteins associated with cell apoptosis and cell death programming.

, the efficacy of allicin also was attributed to the function of bioactive compounds stimulating the protein involved "on" or "off" switch of cell apoptosis, as well as inhibiting the antioxidant enzymes produced by the cancer cells.

Taken together, phytochemical allicin may be considered a bioactive compound for reducing risk and combined with the primary medicine for the treatment of endometrial cancer.

However, intake of allicin in the form of a supplement should be taken with extreme care as acute toxicity was reported in a number of cases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. (PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH. (PubMed)
(3) Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction by Evan L. Busch, Marta Crous-Bou, Jennifer Prescott, Maxine M. Chen, Michael J. Downing, Bernard A. Rosner, George L. Mutter and Immaculata De Vivo. (AACR)

#Herbal #Ashwagandha Porcesses Anti Inflammatory Effects Agaisnt #RheumatoidArthritis RA, Researchers Find

Kyle J. Norton

Rheumatoid Arthritis, a type of musculoskeletal disorder (MSD) is a chronic disorder characterized by inflammation of the flexible (synovial) joints tissues, and organs in the body.

The disease affects more women than men and generally occurs after the age of 50, causing the diminished quality of life of many elders.

Musculoskeletal disorders (MSDs) are medical conditions mostly caused by work-related occupations and working environments, affecting patients’ muscles, joints, tendons, ligaments, and nerves and developing over time.


According to a community sample of 73 females and 32 males aged 85 and over who underwent a standardized examination at home, musculoskeletal pain was reported by 57% of those interviewed.

According to the statistics provided by the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid arthritis was found to induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.

Patient with rheumatoid arthritis (RA) often associates with valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot. The kinematic and kinetic gait changes in rheumatoid arthritis (RA) are the result of a significant reduction in joint motions, and joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,...

Long-term bone damage and the prolonged onset of the disease can induce deformities of the hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.

The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations that can affect daily living and quality of life.

Furthermore, rheumatoid nodules, lumps on the skin, closed to the joint have been found to affect the joints of patients with RA.

Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in the early stage of rheumatoid arthritis.

Dr. Motl RW and Dr. McAuley E. in the assessment of chronic diseases said, " The rationale and the associated onset of chronic disease conditions that influence function, disability, and quality of life (QOL) are embedded in the "Graying of America""(29), including patients with RA.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the treatment of arthritis, researchers examined the effect of Cannabis sativa, Prunella vulgaris, and Withania somnifera) possess anti-inflammatory, rheumatic arthritis properties.

According to the tested analysis, the tested medical plants showed a significant effect on RA by targeting TNF-α through its anti-inflammatory activity.

More precisely, twenty unique molecules found in the medical plants including Withania somnifera were attributed to the utmost binding affinity and least binding energies associated with the interaction of receptor-ligand interactions of residues against RA.

Based on the findings, researchers said, "The RA patients should use reported compounds for the prescription of RA by targeting TNF-α. This report is opening new dimensions for designing innovative therapeutic targets to cure RA.".

Taken together, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of RA, pending the result of a larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withaniasomnifera compounds elucidating the medicinal properties against rheumatoid arthritis by Zaka M1, Sehgal SA2, Shafique S3, Abbasi BH. (PubMed)
(2) Most Common Diseases of elder: The Clinical Trials and Studies of musculoskeletal disorders: Osteoporosis - The Symptoms by Kyle J. Norton
(3) Physical activity, disability, and quality of life in older adults by Motl RW1, McAuley E. (PubMed)

#Phytochemical #Betanin and #Isobetanin, the Powerful Antioxidants In Beetroot Inhibit Diseases Associated with Oxidative Stress

Kyle J. Norton


Antioxidants are stable molecules that inhibit the onset of oxidation caused by free radicals.

Free radicals, on the other hand, are unstable molecules that cause oxidation, with unpaired electrons in the outermost ring.

Free radical scavengers are types of antioxidants that play a critical role in neutralizing free radicals before they can induce a chain reaction which can not be stopped until all unpaired electrons in the outermost are paired.


Overexpression of free radicals or depletion of antioxidant enzymes in the host body can lead to
oxidative stress, an indicator associated with the unbalanced ratio of the levels of antioxidants/free radicals

Epidemiologically, the imbalance ratio of free radicals/antioxidants has been linked to the onset of many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke due to cellular, lipid and protein damage.

However, free radicals have the potential to be extremely harmful contaminants and extremely helpful for the treatment of cancers through their cytotoxic activity because of their high reactivity,

Believe it or not, free radicals present in the body in a moderate amount are important to the body's cardio-functioning, including the promotion of vascular function.

Some researchers in the examination of the effect of antioxidant-rich foods in the risk-free radicals initiation suggested that diet rich in fruits and vegetables and less in meat and process foods have a lower risk of oxidative stress and oxidative stress-related diseases.

The National Centre for Complementary and Integrative Health in the article "Antioxidants: In-Depth" wrote, "Several decades of dietary research findings suggested that consuming greater amounts of antioxidant-rich foods might help to protect against diseases. Because of these results, there has been a lot of research on antioxidant supplements".

And "Observational studies on the typical eating habits, lifestyles, and health histories of large groups of people have shown that those who ate more vegetables and fruits had lower risks of several diseases, including cardiovascular disease, stroke, cancer, and cataracts".

Isobetanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...

In finding a potent ingredient for the treatment of diseases associated with oxidative stress, researchers examined the chemical constituents of betacyanin of Djulis (Chenopodium fromosanum), a native cereal plant in Taiwan.

Betacyanin of Djulis exhibited a significant antioxidant capacity at the maximum absorbance at 530 nm, depending on the pH.

Major chemical compounds that exerted a significant antioxidant capacity are betanin (47.8%), isobetanin (30.0%) with m/z 551.0, and armaranthin (13.6%), isoamaranthinee (8.6%).

According to the purified form, the pigment extract by HPLC, Betanin, and Isobetanin totally accounted for more than 70% of FRAP(ferric-reducing antioxidant power) which plays an important role in this regard of absorptivity for a variety of antioxidants and free radical scavenging capacity.

These results strongly suggested that betanin and isobetanin antioxidants process a strong antioxidant activity that may provide a basis for its sustainable utilization in the food industry.


Taken altogether, isobetanin may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Thermal and pH stability of betacyanin pigment of Djulis (Chenopodium formosanum) in Taiwan and their relation to antioxidant activity" by Tsai PJ, Sheu CH, Wu PH, Sun YF.(PubMed)

Co-Treatment of Curcumin and NVP-BEZ235 Down-Regulate Protein Asspociated with Apoptosis and Survival of Cancer Cells, Reserachers Say

Kyle J. Norton

Cancer is a group of diseases associated with cells growing and multiplying disordered and uncontrollably in the tissue of a specific organ.

Over time, the alternation of the cell DNA on the surface of the inner lining tissue may become progressively worse by penetrating into deeper layers of the infected organs.

At the advanced stage, cells of most invasive tumors can spread to other organs in the body via lymph or blood.

The kidney is an essential organ of our body, that not only plays a critical role in the urinary system, but also regulates electrolytes, and blood pressure, maintains acid-base balance, and produces hormones calcitriol, renin, and erythropoietin.

In the urinary system, the kidney filters blood with billions of glomeruli by separating the cells of blood from plasma.

As the plasma passes into the tubules, some necessary substances are reabsorbed back into the blood, while other wastes, such as urea and ammonium are stored in the pelvis and then into the ureter to the bladder.

Renal cell carcinoma is the most common type of kidney cancer caused by malignant cells of the lining of the tubules in the kidney. Renal cell carcinoma tends first to spread to the lung, but it may also spread to lymph nodes and other organs as well.


Because of less nervousness in the kidney and location, patients in the early stage of renal cell carcinoma are asymptomatic. In other words, kidney tumors can grow without causing any pain and discomfort. The most common symptoms of kidney cancer are
* Abdominal pain that is dull and constant lasting for hours.

*Back pain that is dull and constant lasting for hours.

* Blood in the urine is a result of the break off of the tumor in the tubules.

* Unintentional weight loss
Any intentional weight loss of over 10% is one of the most common symptoms of cancer.

* Flank pain is a sensation of discomfort, distress, or agony around the back and side of the abdomen.

* Swelling and enlargement of the abdomen happens in approximately 15% of all cases of renal cell carcinoma.

*Anemia
If cancer has affected the function of erythropoietin in the production of hemoglobin.

* Varicocele enlargement is a result of the blockage of the left (right) testicular vein by tumor invasion of the left (right) renal vein.

*Hypertension is a result of the secretion of renin by the tumor.

If you experience some of the aforementioned symptoms persistently, please check with your doctor to rule out the possibility of kidney cancer

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of renal cell carcinoma, researchers examined the combined treatment with natural compounds and NVP-BEZ235 in human renal carcinoma Caki cells.


Where NVP-BEZ235 is an inhibitor of signaling pathways associated with the development of kidney tumors.

According to the tested analysis, curcumin markedly induced apoptosis in NVP-BEZ235-treated cells.

Co-treatment with curcumin and NVP-BEZ235 led to the down-regulation of Mcl-1 protein expression Involved the regulation of apoptosis and survival of cancer cells but not mRNA expression in tested cells.

Furthermore, the co-administration also inhibited the protein associated with the anti-apoptotic activity of Bcl-2.

Interestingly, in colon cancer cell line analysis, Combined treatment with NVP-BEZ235 and curcumin reduced Bcl-2 expression in wild-type p53 HCT116 human colon carcinoma cells but not p53-null HCT116 cells.


In skin cells, NVP-BEZ235 combined with curcumin did not have a synergistic effect on normal human skin fibroblasts and normal human mesangial cells.

Based on the findings, researchers suggested that curcumin combined with the NVP-BEZ235 induced human renal carcinoma Caki cells apoptosis by regulating the protein associated with anti-apoptosis accompanied by blocking the activation of proliferative signaling pathways.

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of kidney cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability by Seo BR1, Min KJ1, Cho IJ2, Kim SC2, Kwon TK. (PubMed)
(2) Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells by Li H1, Jin X, Zhang Z, Xing Y, Kong X. (PubMed)
(3) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton

Purified #Cranberry-Derived Proanthocyanidin #Extract (C-PAC) Induces Exptression of Proteins Associated with Cell Death Programming in #EsophagealTumor

Kyle J. Norton

The esophagus formed part of the digestive system is a muscular tube that connects the throat (pharynx) with the stomach located behind the trachea and heart and in front of the spine.

Cancer is a group of chronic diseases associated with irregular cell growth that starts in the cell on the surface of the inner lining tissue of the specific gland and organ before penetrating into deeper layers to form tumors through unlimited cell cycle division.

Over time, most cancers have become progressively worse and spread to other organs in the body via lymph or blood.

Esophageal cancer is not very uncommon in the US caused by malignant cells of the esophagus due to cell DNA alternation.

Primary esophageal cancer has been found to spread to the bottom of the esophagus, stomach, and chest.
According to the statistics, compared to the US, esophageal cancer is more often diagnosed in other parts of the world and is the seventh most common cause of cancer death among men.

Believe it or not, every year, the disease causes the death of 16,000 individuals, including 13,000 men and 3,000 women,

Compared to other cancers the 5-year survival rate for people with esophageal cancer is only 19%.

The exact causes of esophageal cancer are unidentified. However, according to epidemiological studies, aging, male gender, smoking, excessive alcohol drinking, genetic preposition, obesity, and thermal injury to the esophagus are some prevalent factors that increase the risk of the disease.

Some researchers suggested that the increased incidences of esophageal cancer in the Western world over the past few decades may be correlated to the promotion of a high-fat diet.

Dr. Silvano Gallus wrote, "Over the last 30 years, the incidence of squamous-cell carcinoma has decreased in several areas of the world, but adenocarcinoma has risen by over fourfold in the US as well as in Australia and several areas of Europe; its incidence has particularly increased in men".

And, " diets high in saturated fat and cholesterol have been associated with an increased risk (of esophageal cancer)".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of gastrointestinal tumors, researchers examined the effect of a purified cranberry-derived proanthocyanidin extract (C-PAC) on esophageal adenocarcinoma (EAC) cell lines, including acid-sensitive JHAD1 and OE33 cells, and esophageal tumor xenografts in athymic NU/NU mice.

According to the tested assays, C-PAC shared a strong activity in inducing the expression of a protein associated with cell death programming mainly in JHAD1 and OE33 cells.


Autophagy that promotes cancer cell growth and anti-apoptosis of JHAD1 and OE33 cells were also inhibited by the injection of C-PAC.


In vitro, C-PAC-induced cell death was attributed to the deactivation of the phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways expression in the promotion of cancer cellular processes, including cell survival, growth, and differentiation.

Additionally, C-PAC not only inhibited the levels of anti-apoptotic proteins such as BCL-xL, Cytochrome C, and PARP), pathways involved in the occurrence and progression of cancer but also exhibited the expression of proteins that induce cell cycle arrest.

Similarly, in vivo, oral delivery of C-PAC significantly inhibited OE19 tumor xenograft growth as the aforementioned activities.


In other words, in vitro and Vivo purified cranberry-derived proanthocyanidin extract (C-PAC) eradicates the esophageal adenocarcinoma (EAC) cells through several mechanisms involved in pro-apoptosis, anti-anti-apoptosis and blocking cellular division.

Based on the finding, researchers after taking other factors into account wrote, " C-PAC is a potent inducer of EAC cell death and is efficacious in vivo at non-toxic behaviorally achievable concentrations, holding promise for preventive or therapeutic interventions in cohorts at increased risk for EAC, a rapidly rising and extremely deadly malignancy".

Taken together, cranberry extract may be considered a remedy for the prevention and treatment of esophageal cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development in Apcmin/+ mice by Jin D#1, Liu T#1, Dong W1, Zhang Y2, Wang S1, Xie R1, Wang B1, Cao H. (PubMed)
(2) Is There a Link Between Diet and Esophageal Cancer? by Silvano Gallus, and Carlo La Vecchia. (Medscape)

#Healthyfood #Onion Inhibits #LungCancer through Its Cytotoxic Activity, Researchers Say

Kyle J. Norton

The lung is a vital organ formed part of the respiratory system located near the backbone on either side of the heart that inhales oxygen from the air to the bloodstream and exhales carbon dioxide from the bloodstream.

Lung cancer is a medical condition caused by the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.

According to the statistics, in the US, approximately 541,000 Americans are living with lung cancer at some point in their lives. In 2018, approximately 234,000 new cases of lung cancer were diagnosed, representing about 13 percent of all cancer diagnoses.

The exact causes of lung cancer are unknown. Epidemiologically, the prevalent factors associated with an increased risk of lung cancer are
*Smoking
Smoking is a major cause of lung cancer by causing oxidation stress to the lungs due to chemical substances (carcinogens) in the cigarette over time.

* Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.

* Exposure to certain chemicals
The risk of lung cancer is increased for people who inhale or are exposed to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.

* Family history
The risk of lung cancer increases if one of the members of the direct family has lung cancer.

* Lung disease
The risk of lung cancer is increased if you have or previously had certain types of lung disease

* Excessive alcohol drinking
Alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer.


Some researchers suggested that the risk of lung cancer can be decreased by
* Quit smoking
According to statistics, approximate 87% of lung cancer deaths are caused by smoking.

* Eating more fruits and vegetables
These foods contain a high amount of antioxidants which enhance the immune system against the forming of free radicals and prevent the alternation of cell DNA causing abnormal cell growth.

* Avoid Second smokes
Second smoke contains the same amount of carcinogens, exposure to it can increase the risk of lung cancer.

* Avoid environmental chemicals
Avoid exposure to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc.. In the workplace, deal with them by taking maximum precautions and prevention.

* Reduced alcohol intake
Researchers found that increased risk of lung cancer for people who have more than 2 drinks a day.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

In finding a potential compound for the treatment of cancer, researchers examined the effects of onionin A (ONA) derived from the onion in the inhibition of tumor-associated macrophages in the M2 phenotype.

According to the tested analysis.* Onionin A (ONA) inhibits macrophage polarization into the M2 phenotype associated with tumorigenesis by antagonizing the cytotoxic activity of immune cells.


* Onionin also exerted immunosuppressive activity and tumor proliferation, by suppressing signal transducer and activator associated with tumor proliferative promotion.


* In lung tumors, ONA administration significantly suppressed subcutaneous tumor development and lung metastasis in tumor-bearing mice.


* ONA also increased the number of infiltrating lymphocytes against tumor proliferation in tumor tissues.

The efficacy of ONA against the onset and progression of od lung cancer was probably involved in the regulation of tumor proliferation by inhibiting cell-cell interactions between macrophages and tumor cells.

Based on the finding, researchers said, "NA administration enhanced the antitumor effects of cisplatin in the tumor-bearing mice".

Taken together, onion processed with a higher mount of onionin A (ONA) may be considered a remedy for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells by Fujiwara Y1, Horlad H1, Shiraishi D1, Tsuboki J1, Kudo R1, Ikeda T2, Nohara T2, Takeya M1, Komohara Y. (PubMed)
(2) Lung Cancer by Kyle J. Norton

#Phytochemical #Lycopene Inhibits the Growth Head and Neck Cancer through Its Cytotoxic and Apopyotic Activity, Researchers Say

Kyle J. Norton

Cancer is a group of diseases caused by cell growth irregularly in the affected tissue caused by DNA alternation.
Head and neck cancer is a group of cancers originating from the mouth, nose, throat, larynx, sinuses, or salivary glands.

According to the statistics provided by the Canadian Cancer Society, approximately 4,300 Canadians are diagnosed with cancer of the head and neck every year. Head and neck cancer also caused the death of nearly 1,610 Canadians.

The overall survival rate of 5 years after diagnosis is 62% tobacco use, alcohol consumption, and viral infection including human papillomavirus (HPV) infection (for oropharyngeal cancer), and Epstein-Barr virus (EBV) infection (for nasopharyngeal cancer).

Some researchers suggested that diet patterns may have a strong impact on the onset of the disease.

Dr. Shu-Chun Chuang, the lead scientist wrote, "A dietary pattern score combining high fruit and vegetable intake and low red meat intake, was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model".

And, "Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR=0.90, 95% CI=0.84–0.97)".


In other words, if you are a Western diet follower, your risk of head and neck cancer increases substantially compared to those who follow a traditional diet.

The most common symptoms of head and neck cancer are totally depending on the location of cancer including a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice.

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In the urgency to find a potential compound for the treatment of head and neck cancer, researchers examined the lycopene overload and cytotoxic effects on HNSCC cells.

According to the cell analysis, lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time‑ and dose‑dependent manner.

Furthermore, the injection of lycopene not only provided the clearest increase in growth inhibition by cell apoptosis but also limited the cancer cell invasive activity at a dose of 25 µM.

More precisely, lycopene killed cancer cells by exhibiting the protein associated with cell death programming and apoptosis.

Dr. Ye M, the lead scientist after taking other factors into account wrote, " lycopene induced the upregulation of the pro‑apoptotic protein, B‑cell lymphoma‑associated X protein".


Taken altogether, lycopene may be considered a supplement for the prevention and treatment of head and neck cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma by Ye M1, Wu Q1, Zhang M1, Huang J. (PubMed)
(2) Levels of fat-soluble micronutrients and 2,6-cyclolycopene-1,5-diol in head and neck cancer patients by Djuric Z1, Ronis DL, Fowler KE, Ren J, Duffy SA. (PubMed)
(3) Diet and the Risk of Head and Neck Cancer: A Pooled Analysis in the INHANCE Consortium by
Shu-Chun Chuang,1,2 Mazda Jenab,2 Julia E. Heck,3 Cristina Bosetti,4 Renato Talamini,5Keitaro Matsuo,6 Xavier Castellsague,7 Silvia Franceschi,2 Rolando Herrero,8Deborah M. Winn,9 Carlo La Vecchia,4,10 Hal Morgenstern,11 Zuo-Feng Zhang,3 Fabio Levi,12Luigino Dal Maso,5 Karl Kelsey,13 Michael D. McClean,14 Thomas Vaughan,15Philip Lazarus,16 Joshua Muscat,16 Heribert Ramroth,17 Chu Chen,15 Stephen M. Schwartz,15Jose Eluf-Neto,18 Richard B. Hayes,19 Mark Purdue,9 Stefania Boccia,20,21 Gabriella Cadoni,22David Zaridze,23 Sergio Koifman,24 Maria Paula Curado,2 Wolfgang Ahrens,25Simone Benhamou,26 Elena Matos,27 Pagona Lagiou,28 Neonilla Szeszenia-Dabrowska,29Andrew F. Olshan,30 Leticia Fernandez,31 Ana Menezes,32 Antonio Agudo,33Alexander W. Daudt,34 Franco Merletti,35 Gary J. Macfarlane,36 Kristina Kjaerheim,37Dana Mates,38 Ivana Holcatova,39 Stimson Schantz,40 Guo-Pei Yu,40 Lorenzo Simonato,41Hermann Brenner,42 Heiko Mueller,42 David I. Conway,43 Peter Thomson,44Eleonora Fabianova,45 Ariana Znaor,46 Peter Rudnai,47 Claire M. Healy,48 Gilles Ferro,2Paul Brennan,2 Paolo Boffetta,49,50 and Mia Hashibe. (PMC)