Co-Treatment of Curcumin and NVP-BEZ235 Down-Regulate Protein Asspociated with Apoptosis and Survival of Cancer Cells, Reserachers Say

Kyle J. Norton

Cancer is a group of diseases associated with cells growing and multiplying disordered and uncontrollably in the tissue of a specific organ.

Over time, the alternation of the cell DNA on the surface of the inner lining tissue may become progressively worse by penetrating into deeper layers of the infected organs.

At the advanced stage, cells of most invasive tumors can spread to other organs in the body via lymph or blood.

The kidney is an essential organ of our body, that not only plays a critical role in the urinary system, but also regulates electrolytes, and blood pressure, maintains acid-base balance, and produces hormones calcitriol, renin, and erythropoietin.

In the urinary system, the kidney filters blood with billions of glomeruli by separating the cells of blood from plasma.

As the plasma passes into the tubules, some necessary substances are reabsorbed back into the blood, while other wastes, such as urea and ammonium are stored in the pelvis and then into the ureter to the bladder.

Renal cell carcinoma is the most common type of kidney cancer caused by malignant cells of the lining of the tubules in the kidney. Renal cell carcinoma tends first to spread to the lung, but it may also spread to lymph nodes and other organs as well.


Because of less nervousness in the kidney and location, patients in the early stage of renal cell carcinoma are asymptomatic. In other words, kidney tumors can grow without causing any pain and discomfort. The most common symptoms of kidney cancer are
* Abdominal pain that is dull and constant lasting for hours.

*Back pain that is dull and constant lasting for hours.

* Blood in the urine is a result of the break off of the tumor in the tubules.

* Unintentional weight loss
Any intentional weight loss of over 10% is one of the most common symptoms of cancer.

* Flank pain is a sensation of discomfort, distress, or agony around the back and side of the abdomen.

* Swelling and enlargement of the abdomen happens in approximately 15% of all cases of renal cell carcinoma.

*Anemia
If cancer has affected the function of erythropoietin in the production of hemoglobin.

* Varicocele enlargement is a result of the blockage of the left (right) testicular vein by tumor invasion of the left (right) renal vein.

*Hypertension is a result of the secretion of renin by the tumor.

If you experience some of the aforementioned symptoms persistently, please check with your doctor to rule out the possibility of kidney cancer

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of renal cell carcinoma, researchers examined the combined treatment with natural compounds and NVP-BEZ235 in human renal carcinoma Caki cells.


Where NVP-BEZ235 is an inhibitor of signaling pathways associated with the development of kidney tumors.

According to the tested analysis, curcumin markedly induced apoptosis in NVP-BEZ235-treated cells.

Co-treatment with curcumin and NVP-BEZ235 led to the down-regulation of Mcl-1 protein expression Involved the regulation of apoptosis and survival of cancer cells but not mRNA expression in tested cells.

Furthermore, the co-administration also inhibited the protein associated with the anti-apoptotic activity of Bcl-2.

Interestingly, in colon cancer cell line analysis, Combined treatment with NVP-BEZ235 and curcumin reduced Bcl-2 expression in wild-type p53 HCT116 human colon carcinoma cells but not p53-null HCT116 cells.


In skin cells, NVP-BEZ235 combined with curcumin did not have a synergistic effect on normal human skin fibroblasts and normal human mesangial cells.

Based on the findings, researchers suggested that curcumin combined with the NVP-BEZ235 induced human renal carcinoma Caki cells apoptosis by regulating the protein associated with anti-apoptosis accompanied by blocking the activation of proliferative signaling pathways.

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of kidney cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability by Seo BR1, Min KJ1, Cho IJ2, Kim SC2, Kwon TK. (PubMed)
(2) Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells by Li H1, Jin X, Zhang Z, Xing Y, Kong X. (PubMed)
(3) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton

Purified #Cranberry-Derived Proanthocyanidin #Extract (C-PAC) Induces Exptression of Proteins Associated with Cell Death Programming in #EsophagealTumor

Kyle J. Norton

The esophagus formed part of the digestive system is a muscular tube that connects the throat (pharynx) with the stomach located behind the trachea and heart and in front of the spine.

Cancer is a group of chronic diseases associated with irregular cell growth that starts in the cell on the surface of the inner lining tissue of the specific gland and organ before penetrating into deeper layers to form tumors through unlimited cell cycle division.

Over time, most cancers have become progressively worse and spread to other organs in the body via lymph or blood.

Esophageal cancer is not very uncommon in the US caused by malignant cells of the esophagus due to cell DNA alternation.

Primary esophageal cancer has been found to spread to the bottom of the esophagus, stomach, and chest.
According to the statistics, compared to the US, esophageal cancer is more often diagnosed in other parts of the world and is the seventh most common cause of cancer death among men.

Believe it or not, every year, the disease causes the death of 16,000 individuals, including 13,000 men and 3,000 women,

Compared to other cancers the 5-year survival rate for people with esophageal cancer is only 19%.

The exact causes of esophageal cancer are unidentified. However, according to epidemiological studies, aging, male gender, smoking, excessive alcohol drinking, genetic preposition, obesity, and thermal injury to the esophagus are some prevalent factors that increase the risk of the disease.

Some researchers suggested that the increased incidences of esophageal cancer in the Western world over the past few decades may be correlated to the promotion of a high-fat diet.

Dr. Silvano Gallus wrote, "Over the last 30 years, the incidence of squamous-cell carcinoma has decreased in several areas of the world, but adenocarcinoma has risen by over fourfold in the US as well as in Australia and several areas of Europe; its incidence has particularly increased in men".

And, " diets high in saturated fat and cholesterol have been associated with an increased risk (of esophageal cancer)".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of gastrointestinal tumors, researchers examined the effect of a purified cranberry-derived proanthocyanidin extract (C-PAC) on esophageal adenocarcinoma (EAC) cell lines, including acid-sensitive JHAD1 and OE33 cells, and esophageal tumor xenografts in athymic NU/NU mice.

According to the tested assays, C-PAC shared a strong activity in inducing the expression of a protein associated with cell death programming mainly in JHAD1 and OE33 cells.


Autophagy that promotes cancer cell growth and anti-apoptosis of JHAD1 and OE33 cells were also inhibited by the injection of C-PAC.


In vitro, C-PAC-induced cell death was attributed to the deactivation of the phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways expression in the promotion of cancer cellular processes, including cell survival, growth, and differentiation.

Additionally, C-PAC not only inhibited the levels of anti-apoptotic proteins such as BCL-xL, Cytochrome C, and PARP), pathways involved in the occurrence and progression of cancer but also exhibited the expression of proteins that induce cell cycle arrest.

Similarly, in vivo, oral delivery of C-PAC significantly inhibited OE19 tumor xenograft growth as the aforementioned activities.


In other words, in vitro and Vivo purified cranberry-derived proanthocyanidin extract (C-PAC) eradicates the esophageal adenocarcinoma (EAC) cells through several mechanisms involved in pro-apoptosis, anti-anti-apoptosis and blocking cellular division.

Based on the finding, researchers after taking other factors into account wrote, " C-PAC is a potent inducer of EAC cell death and is efficacious in vivo at non-toxic behaviorally achievable concentrations, holding promise for preventive or therapeutic interventions in cohorts at increased risk for EAC, a rapidly rising and extremely deadly malignancy".

Taken together, cranberry extract may be considered a remedy for the prevention and treatment of esophageal cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development in Apcmin/+ mice by Jin D#1, Liu T#1, Dong W1, Zhang Y2, Wang S1, Xie R1, Wang B1, Cao H. (PubMed)
(2) Is There a Link Between Diet and Esophageal Cancer? by Silvano Gallus, and Carlo La Vecchia. (Medscape)

#Healthyfood #Onion Inhibits #LungCancer through Its Cytotoxic Activity, Researchers Say

Kyle J. Norton

The lung is a vital organ formed part of the respiratory system located near the backbone on either side of the heart that inhales oxygen from the air to the bloodstream and exhales carbon dioxide from the bloodstream.

Lung cancer is a medical condition caused by the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.

According to the statistics, in the US, approximately 541,000 Americans are living with lung cancer at some point in their lives. In 2018, approximately 234,000 new cases of lung cancer were diagnosed, representing about 13 percent of all cancer diagnoses.

The exact causes of lung cancer are unknown. Epidemiologically, the prevalent factors associated with an increased risk of lung cancer are
*Smoking
Smoking is a major cause of lung cancer by causing oxidation stress to the lungs due to chemical substances (carcinogens) in the cigarette over time.

* Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.

* Exposure to certain chemicals
The risk of lung cancer is increased for people who inhale or are exposed to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.

* Family history
The risk of lung cancer increases if one of the members of the direct family has lung cancer.

* Lung disease
The risk of lung cancer is increased if you have or previously had certain types of lung disease

* Excessive alcohol drinking
Alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer.


Some researchers suggested that the risk of lung cancer can be decreased by
* Quit smoking
According to statistics, approximate 87% of lung cancer deaths are caused by smoking.

* Eating more fruits and vegetables
These foods contain a high amount of antioxidants which enhance the immune system against the forming of free radicals and prevent the alternation of cell DNA causing abnormal cell growth.

* Avoid Second smokes
Second smoke contains the same amount of carcinogens, exposure to it can increase the risk of lung cancer.

* Avoid environmental chemicals
Avoid exposure to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc.. In the workplace, deal with them by taking maximum precautions and prevention.

* Reduced alcohol intake
Researchers found that increased risk of lung cancer for people who have more than 2 drinks a day.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

In finding a potential compound for the treatment of cancer, researchers examined the effects of onionin A (ONA) derived from the onion in the inhibition of tumor-associated macrophages in the M2 phenotype.

According to the tested analysis.* Onionin A (ONA) inhibits macrophage polarization into the M2 phenotype associated with tumorigenesis by antagonizing the cytotoxic activity of immune cells.


* Onionin also exerted immunosuppressive activity and tumor proliferation, by suppressing signal transducer and activator associated with tumor proliferative promotion.


* In lung tumors, ONA administration significantly suppressed subcutaneous tumor development and lung metastasis in tumor-bearing mice.


* ONA also increased the number of infiltrating lymphocytes against tumor proliferation in tumor tissues.

The efficacy of ONA against the onset and progression of od lung cancer was probably involved in the regulation of tumor proliferation by inhibiting cell-cell interactions between macrophages and tumor cells.

Based on the finding, researchers said, "NA administration enhanced the antitumor effects of cisplatin in the tumor-bearing mice".

Taken together, onion processed with a higher mount of onionin A (ONA) may be considered a remedy for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells by Fujiwara Y1, Horlad H1, Shiraishi D1, Tsuboki J1, Kudo R1, Ikeda T2, Nohara T2, Takeya M1, Komohara Y. (PubMed)
(2) Lung Cancer by Kyle J. Norton

#Phytochemical #Lycopene Inhibits the Growth Head and Neck Cancer through Its Cytotoxic and Apopyotic Activity, Researchers Say

Kyle J. Norton

Cancer is a group of diseases caused by cell growth irregularly in the affected tissue caused by DNA alternation.
Head and neck cancer is a group of cancers originating from the mouth, nose, throat, larynx, sinuses, or salivary glands.

According to the statistics provided by the Canadian Cancer Society, approximately 4,300 Canadians are diagnosed with cancer of the head and neck every year. Head and neck cancer also caused the death of nearly 1,610 Canadians.

The overall survival rate of 5 years after diagnosis is 62% tobacco use, alcohol consumption, and viral infection including human papillomavirus (HPV) infection (for oropharyngeal cancer), and Epstein-Barr virus (EBV) infection (for nasopharyngeal cancer).

Some researchers suggested that diet patterns may have a strong impact on the onset of the disease.

Dr. Shu-Chun Chuang, the lead scientist wrote, "A dietary pattern score combining high fruit and vegetable intake and low red meat intake, was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model".

And, "Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR=0.90, 95% CI=0.84–0.97)".


In other words, if you are a Western diet follower, your risk of head and neck cancer increases substantially compared to those who follow a traditional diet.

The most common symptoms of head and neck cancer are totally depending on the location of cancer including a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice.

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In the urgency to find a potential compound for the treatment of head and neck cancer, researchers examined the lycopene overload and cytotoxic effects on HNSCC cells.

According to the cell analysis, lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time‑ and dose‑dependent manner.

Furthermore, the injection of lycopene not only provided the clearest increase in growth inhibition by cell apoptosis but also limited the cancer cell invasive activity at a dose of 25 µM.

More precisely, lycopene killed cancer cells by exhibiting the protein associated with cell death programming and apoptosis.

Dr. Ye M, the lead scientist after taking other factors into account wrote, " lycopene induced the upregulation of the pro‑apoptotic protein, B‑cell lymphoma‑associated X protein".


Taken altogether, lycopene may be considered a supplement for the prevention and treatment of head and neck cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma by Ye M1, Wu Q1, Zhang M1, Huang J. (PubMed)
(2) Levels of fat-soluble micronutrients and 2,6-cyclolycopene-1,5-diol in head and neck cancer patients by Djuric Z1, Ronis DL, Fowler KE, Ren J, Duffy SA. (PubMed)
(3) Diet and the Risk of Head and Neck Cancer: A Pooled Analysis in the INHANCE Consortium by
Shu-Chun Chuang,1,2 Mazda Jenab,2 Julia E. Heck,3 Cristina Bosetti,4 Renato Talamini,5Keitaro Matsuo,6 Xavier Castellsague,7 Silvia Franceschi,2 Rolando Herrero,8Deborah M. Winn,9 Carlo La Vecchia,4,10 Hal Morgenstern,11 Zuo-Feng Zhang,3 Fabio Levi,12Luigino Dal Maso,5 Karl Kelsey,13 Michael D. McClean,14 Thomas Vaughan,15Philip Lazarus,16 Joshua Muscat,16 Heribert Ramroth,17 Chu Chen,15 Stephen M. Schwartz,15Jose Eluf-Neto,18 Richard B. Hayes,19 Mark Purdue,9 Stefania Boccia,20,21 Gabriella Cadoni,22David Zaridze,23 Sergio Koifman,24 Maria Paula Curado,2 Wolfgang Ahrens,25Simone Benhamou,26 Elena Matos,27 Pagona Lagiou,28 Neonilla Szeszenia-Dabrowska,29Andrew F. Olshan,30 Leticia Fernandez,31 Ana Menezes,32 Antonio Agudo,33Alexander W. Daudt,34 Franco Merletti,35 Gary J. Macfarlane,36 Kristina Kjaerheim,37Dana Mates,38 Ivana Holcatova,39 Stimson Schantz,40 Guo-Pei Yu,40 Lorenzo Simonato,41Hermann Brenner,42 Heiko Mueller,42 David I. Conway,43 Peter Thomson,44Eleonora Fabianova,45 Ariana Znaor,46 Peter Rudnai,47 Claire M. Healy,48 Gilles Ferro,2Paul Brennan,2 Paolo Boffetta,49,50 and Mia Hashibe. (PMC)

#Bioactive #Sulforaphane Inhibits Parameters Associated with Increasing the Store of Fat in Liver and Abdominal Cavity, According to Studies

Kyle J. Norton

Dithiolthiones, a bioactive ingredient found in cruciferous vegetables may have an effect on reducing the risk of obesity in chronic consumption, some scientists suggested.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Obesity is a medical condition caused by excess body fat accumulated over time.

And, overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.

According to the statistics, 68% of the American population is either overweight or obese.

Some researchers suggested that the prevalent and widespread obesity in the Western world not only increased the burden of health care and economic costs but also induced a reduced quality of life for adults due to chronic ailments.

In the comparison of the obesity rate today and 50 years ago, the Centers for Disease Control statistic showed that the obesity rate has skyrocketed by more than 185 percent among American adults over the last 50 years, and the rate of extreme obesity among children have tripled during the same time period.

These results clearly suggested that adults today must have something different in their daily activities that contributes to these significant changes.

Some researchers suggested that lack of exercise may be one of the most prevalent risk factors that induces the onset of obesity.

Dr. Petri, the lead scientist in the examine the role of physical activity and exercise in obesity and weight said, "Obesity is caused by a consistent decline in daily energy expenditure is not supported either by objective measures of energy expenditure or physiological theory of weight gain alone. However, since voluntary exercise is the most important discretionary component of total daily energy expenditure, it can affect energy balance".


This conclusion indicated that lack of exercise and over-nutrient consumption work together to facilitate the onset of overweight and obesity.

In the concern of obesity widespread in the American population, researchers examine the anti-obesity effect of sulforaphane in the animal model. C57BL/6N mice in the study. were fed a normal diet (ND), HFD, or HFD plus 0.1% sulforaphane (SFN) for 6 weeks.


According to the food efficiency ratios compared to the untreated control, the sulforaphane treatment group showed a lower body weight. SFN attenuated HFD-induced visceral adiposity, adipocyte hypertrophy associated with increasing the store of fat within the abdominal cavity, and fat accumulation in the liver.


Furthermore, Serum total cholesterol leptin, and liver triglyceride levels were lower in HFD-SFN-fed mice than in HFD-fed mice.


The efficacy of SFN in the anti-fat deposit was attributed to the decreased expression of a protein that plays a critical in reducing triglyceride levels and regulating energy homeostasis and increased adiponectin expression in the modulation of glucose and fatty acid oxidation.
Taking foods containing sulforaphane may be effective in managing weight loss for obese patients accompanied by a change of lifestyle with more vegetables and fruits into a diet.

In a highly palatable (HP) diet of male Wistar rats, injection of sulforaphane (SFN, 1 mg kg⁻¹, 4 months treatment)exerted some beneficial effects on obesity and insulin resistance.

Moreover, glucose tolerance was lower in the HP diet groups, especially in the HP group treated with SFN. Except for the liver triacylglycerols.

Moreover, SFN at the specific dose was found to accentuate glucose intolerance and affect the GLUT3 protein in facilitating the transport of glucose across the plasma membranes of mammalian cells in the cerebral cortex and hypothalamus in the HP diet group treated with SFN.

Taken together, plant base sulforaphane may be considered a bioactive compound for the prevention and treatment of obesity with no side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Choi KM1, Lee YS1, Kim W1, Kim SJ2, Shin KO1, Yu JY3, Lee MK1, Lee YM1, Hong JT1, Yun YP1, Yoo HS4. (PubMed)
(2) Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet by Souza CG1, Riboldi BP, Hansen F, Moreira JD, Souza DG, de Assis AM, Brum LM, Perry ML, Souza DO. (PubMed)
(3) Sulforaphane induced adipolysis via hormone-sensitive lipase activation, regulated by AMPK signaling pathway by Lee JH1, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW, Park SY. (PubMed)
(4) The role of physical activity and exercise in obesity and weight management: Time for critical appraisal by PetriWiklund. (Research Gate)

#Cranberry in the Promotion of Balancing Ratio of Gut Microbiota, Researchers Find

Kyle J. Norton

Gut microbiota is a complex community with over a trillion microorganisms that lives in our digestive tracts.
According to the ESMN, the microbiota can weigh up to 2 kg, including 1/3 of gut microbiota found in most people, comapred to 2/3 that are specific to individuals depending on geography, environment, and lifestyle.


In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.

A balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production of vitamins, improvement of digestive functioning, and modulation of the immune function.


The use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illnesses such as inflammatory bowel disease, obesity, cancer, and autism.


Unhealthy gut microbiota has been found to
* Decrease the interaction with the immune function against inflammatory immune disorders.

* Increase the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Reduce nutrient extraction from the diet, thus increasing the risk of obesity and obesity complications.

* Increase the risk of controlling brain insulin signaling and metabolite levels that can lead to bad neurobehaviors.

Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can affect the development of not only intestinal but also systemic autoimmune diseases.

Compared to probiotics, the prebiotics is compound in food that induces the growth or activity of beneficial microorganisms in the gut.

In other definition, it is a special form of dietary fiber that acts as a fertilizer that promotes the growth of good bacteria in your gut.

In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.

In other words, prebiotics raise the levels of healthy bacteria against bad bacteria.


Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the promotion of digestive functioning, researchers examined the effect of cranberries' impact on gut microbiota.

The randomized, double-blind, cross-over, controlled design trial included a total of 11 healthy adults consumed for 5 days each a control diet (animal-based diet (meats, dairy products, and simple sugars) plus 30 g/day placebo powder) and a cranberry diet (animal-based diet plus 30 g/day freeze-dried whole cranberry powder).

According to the tested analysis of the stool, urine, and blood samples, compared to the pre-control diet, the control diet modified 46 taxonomic clades in the gut, including an increase in the abundance of Firmicutes and decrease in Bacteroidetes and increased bacteria-derived deoxycholic acid and decreased acetate and butyrate in stool

In other words, the control diet induces a significant change in gut microbiotas by favoring the "bad" organisms.

Comapred to the post-control diet, the cranberry diet modified 9 taxonomic clades, including a decrease in the abundance of Firmicutes and an increase in Bacteroidetes in the flavor of the good organisms in the gut.

Furthermore, cranberry promoted the balancing ratio of gut microbiotas by attenuating control diet-induced increase in secondary bile acids decreasing the short-chain fatty acids (SCFA), and increasing urinary anthocyanins and bacterially-derived phenolic acids.

Based on the findings, researchers said, "an animal-based diet altered the microbiota composition to a less favorable profile, increased carcinogenic bile acids, and decreased beneficial SCFA. Cranberries attenuated the impact of the animal-based diet on microbiota composition, bile acids, and SCFA, evidencing their capacity to modulate the gut microbiota".

Taken together, cranberry may be considered a remedy for the promotion of gut health, pending the confirmation of the larger sample size and multicenter human study.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberries attenuate animal-based diet-induced changes in microbiota composition and functionality: a randomized crossover controlled feeding trial by Rodríguez-Morató J1, Matthan NR2, Liu J3, de la Torre R4, Chen CO. (PubMed)
(2) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher, Adam Junka, and Marzenna Bartoszewicz. (PMC)

#Cranberry's #Catabolites Improve Parameters Associated with the Promotion of #CardioMetabolicHealth, Researchers Show

Kyle J. Norton

Cardiometabolic risk is a condition that estimates the possibility of developing atherosclerotic cardiovascular (CV) disease and diabetes mellitus.

Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.

Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.

More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,

According to the statistics provided by the American Heart Association, approximately 84 million people in the US live with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.

Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.

Depending on the location of the blockage, if the reduced blood flow occurs in the brain, it will cause the death of the brain cells, leading to stroke.

However, if the reduced blood flow occurs in the heart, it will cause damage to the heart tissues, leading to heart disease.

The most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium, and other chemical substances in the artery

Most people with atherosclerosis are asymptomatic at the early stage.

Diabetes is a medical condition characterized by insufficient insulin in the bloodstream. or insulins in the bloodstream are not used properly to convert glucose to energy.

Epidemiologically, diabetes is caused by either the beta cells in the pancreas died-off or insulin receptors with a function that use insulin to convert glucose to energy clogged up by fat or cholesterol.

In a healthy individual, after eating, the rise of blood glucose triggers the production of insulin by the pancreas into the bloodstream After you eat, your blood sugar (glucose) rises. This rise in glucose triggers your pancreas to release insulin into the bloodstream that travels through the blood to your body's cells before converting glucose into energy or storing it for use later.

In other words, insulin is released by the pancreas joints with the Insulin receptors on the outer part of a cell that binds insulin in the blood to convert glucose to energy.


Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of cardiometabolic health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function and cardiometabolic risk factors.

In cardiometabolic health, cranberry constituents and their bioactive catabolites improved the
serum lipid profiles reduced the levels of blood pressure.

Furthermore, the endothelial functions associated with vascular relaxation and contraction, and glucose regulation are involved in the regulation of glucose metabolism. and a variety of biomarkers associated with inflammation and oxidative stress in the induction of CVD and diabetes were also inhibited by the cranberry constituents and their bioactive catabolites

Based on the findings, researchers said, " These results warrant further research, particularly studies dedicated to the elucidation of dose-response relations, pharmacokinetic/metabolomics profiles, and relevant biomarkers of action with the use of fully characterized cranberry products.".

Taken together, cranberry may be considered a remedy for the improvement of cardiometabolic health, pending the confirmation of the larger sample size, and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)