#Greentea inhibits the Risk of Chronic Inflammatory Diseases through Its Antioxidant Activity, Researchers Find

Kyle J. Norton

Good news for people with chronic inflammatory diseases, green tea polyphenols (GrTPs) is found to reduce the risk and progression of the diseases through the exhibition of potent antioxidants in regulating vital signaling pathways involved production of inflammatory cytokines. a renowned institute study suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger to each drink will attenuate the expression.

Chronic inflammation diseases are medical conditions caused by the overreaction of the immune system in protection against microbial invasion and damage to organs due to injury, affecting the tissue healing process, which can lead to life-long debilitation loss of tissue function, and organ failure.


According to the University of Kentucky Medical Center, green tea phytochemical polyphenols protect our body against inflammation through actions in intercepting the surge of inflammatory markers like cytokines and the production of cyclooxygenase-2 in innated anti-inflammatory cytokines.

In chronic Inflammatory Bowel Disease patients, catechin isolated from green tea enhanced the antioxidant production such as such as glutathione peroxidases (GPO) and glutathione (GSH), in significantly inhibiting excessive oxidative stress through direct or indirect in reducing the oxidative damage to the colon.


Dr. Fan FY, the lead author said, "Catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways( involved proinflammation specifically)".


Particularly, the study also specified the impression of antioxidant catechin in stabilizing the structure of the gastrointestinal micro-ecological environment via promoting the proliferation of beneficial intestinal bacteria and regulating the balance of intestinal flora for induction of relief in patients with IBD.

Furthermore, in a psoriasis mouse model, BALB/c mice topically treated with IMQ for 6 consecutive days, displayed a significant alleviated psoriasiform dermatitis, improved the skin pathological structure by reducing the expression of epidermal PCNA(Base cells), and promoted the expression of caspase-14 involved in inflammation.

In fact, according to the study, the efficacy of Epigallocatechin-3-gallate (EGCG), for the treatment of
psoriasis-like inflammation is the result of the phytochemical functions in anti-inflammatory, immune regulatory, and antioxidant activation.

Taking together, green tea may be used as a protectively functional food in the prevention and treatment of chronic inflammatory diseases, but regular large amounts of injections should be avoided to prevent toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Chronic Inflammatory Diseases and Green Tea Polyphenols by Oz HS1. (PubMed)
(2) Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease by Fan FY1, Sang LX2, Jiang M3.(PubMed)

#Coffee and #CoffeeCaffeine Process Anti-Proliferative and Anti-Metastatic Activity in Subtype #ProstateCancer, According to Studies

Kyle J. Norton

Good news for men coffee lovers, coffee and coffee caffeine consumption daily and regularly are associated with attenuated risk and treatment of prostate cancer, the epidemiological study suggested.
Coffee has become a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Prostate Cancer is a medical condition characterized by cell growth disorderly and uncontrollable in the prostate.

The study of the efficacy of coffee intake and risk of prostate cancer (PC-3 and DU145) on 6,989 men of the Moli-Sani cohort aged ≥50 years showed that
1. Risk of prostate cancer reduced by 53% in people drinking over>3 cups/day is compared to participants at the lowest consumption (0-2 cups/day)
2. Injection of caffeine in both cancer cell lines PC-3 and DU145 showed substantial activity in the reduction of proliferative and metastatic behaviors.

Caffeine demonstration exerted significant anti-proliferative and anti-metastatic activity on two prostate cancer cell lines may be attributed to its bioactive compounds in the expression of anti-cancer in various mechanisms.
Other, in the selection of twenty-eight studies (14 case-control and 14 cohort studies) on coffee caffeine (CC) with 42399 PC patients for the final meta-analysis searched from databases of Pubmed and Embase, researchers, filed the following results

1. There was no significant association of prostate cancer in regard to high versus non/lowest intake.
2. Coffee and coffee caffeine intake showed a localized effect in a subtype of prostate cancer but not advanced prostate cancer.

These results showed a significant effect of coffee in reduced risk of early-stage prostate cancer and coffee is not associated with the risk of prostate cancer.



More profoundly in the report of a prospective analysis of 47,911 men with an intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter in the Health Professionals Follow-up Study
1. Men, drinking six or more cups per day had the lowest relative risk for overall prostate cancer compared to nondrinkers.

2. Overall, Coffee consumption was not associated with the risk of nonadvanced or low-grade prostate cancers and was only weakly inversely associated with high-grade prostate cancer

3. There was no differential effect of regular and decaffeinated coffee in the ameliorated the risk of prostate cancer.
Taking it all together, there is no doubt that coffee and coffee caffeine intake were associated linearly to
reduced risk of localized advanced and lethal prostate cancer, Risk of cancer is also reduced proportionally with an additional cup of coffee consumed.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) An Up-to-date Meta-analysis of Coffee Consumption and Risk of Prostate Cancer by Xia J1, Chen J2, Xue JX3, Yang J3, Wang ZJ3.(PubMed)
(2) Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli-sani cohort and cellular models by Pounis G1, Tabolacci C2, Costanzo S1, Cordella M2, Bonaccio M1, Rago L3, D'Arcangelo D4, Filippo Di Castelnuovo A1, de Gaetano G1, Donati MB1, Iacoviello L1,5, Facchiano F2; Moli-sani study investigators6.(PubMed)
(3) Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study by Wilson KM1, Kasperzyk JL, Rider JR, Kenfield S, van Dam RM, Stampfer MJ, Giovannucci E, Mucci LA.(PubMed)

#Brassica Oleracea Vegetable's #Isothiocyanates (ITCs) Isolated from Purple Cabbage Extract Inhibit the Risk of #ColorectalCancer, Researchers Say

Kyle J. Norton

The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and breaks down certain materials in the feces into substances, some of them to be reabsorbed and reused by the body.

Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells' DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increase in age, family and personal history, and genetic preposition are some of the prevalent risks of the disease.

Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.

In finding a potential whole for the treatment of cancer, researchers examined the effect of principal bioactive compounds, isothiocyanates (ITCs) on a colorectal cancer cell line (HT-29).


According to the chemicals analysis, purple cabbage extract showed the highest ITC concentration per gram, fresh weight, followed by black cabbage and Romanesco cauliflower.

ITC at the concentrations of 7.08 microg/mL decreased cancer cell viability by inducing the caspase-3 associated with cell death and DNA fragmentation at 48h.

Brussels sprouts showed the strongest effects on cell viability and caspase-3 activity.

Furthermore, all varieties of Brassica Oleracea with rich sources of ITCs potently inhibit the growth of colon cancer cells by inducing apoptosis.

All the extracts showed anticancer activity at ITC concentrations of between 3.54 to 7.08 mg/mL,

Based on the findings, researchers said, " ITC concentration and the chemopreventive responses of plant extracts vary among the varieties of Brassica Oleracea studied and among their cultivars".

Taken altogether, Brassica Oleracea vegetables may be considered functional foods for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.

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How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of apoptosis in HT-29 cells by extracts from isothiocyanates-rich varieties of Brassica oleracea by Mas S1, Crescenti A, Gassó P, Deulofeu R, Molina R, Ballesta A, Kensler TW, Lafuente A. (PubMed)

#GreenTea Improves #InsulinSensitivity and Glycaemic Control in #Diabetes, According to Studies

Kyle J. Norton

Green with a ton of phytochemicals has been found to process various health benefits reported by large numbers of research and studies. However, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" according to traditional Chinese medicine's Yin-Yang theory. It is recommended to add a slice of ginger to your drink for the purpose of neutralization.

Recently study by a renowned institute postulated that regular green tea intake may be associated with reduced risk of developed hyperglycemia in a healthy individual and prevented the early onset of diabetes in people with hyperglycemia.


According to the Third Military Medical University, regular consumption of green tea or green tea extract improved insulin sensitivity and glycaemic control in populations with diabetics.

In the review of the literature found in a database of PUBMED, The Cochrane Library, EMBASE, ISI Web of Knowledge, Chinese Biomedical Literature Database and Chinese Scientific Journals Fulltext of 17 trials comprising a total of 1133 subjects suggested that green tea consumption significantly reduced the fasting glucose and hemoglobin A1c (Hb A1c) concentrations by -0.09 mmol/L and -0.30%, respectively.

In the trials with high Jadad score studies, green tea significantly reduced fasting insulin concentrations by -1.16 μIU/mL compared to the nongreen tea drinker group.

Other, in the mice study to evaluate green tea drink (T2 and T3) prepared by adding catechins and epigallocatechin gallate, major constituents isolated from green tea (EGCG) @ 550 mg/500 mL against non-drinker group acted as control (T1), mice fed with T2 and T3 expressed a significant reduced cholesterol and LDL levels and serum glucose and insulin levels with no difference in all functional drink groups but control.

Dr. Ahmad RS, the lead author said, "In contrast to lipid profile, an experimental drink containing EGCG reduced the trait better than catechins-based functional drink".

Furthermore, the compared diabetic effects of 3 selected tea water extracts (TWE) and tea pomace extracts (TPE) and by on rat intestinal α-glucosidase activity in vitro as well as hypoglycemic effects in vivo, insisted that in male Sprague-Dawley (SD) rats fed with tea extracts improved levels of blood glucose level at 30 min after oral intake (0.5 g/kg body wt) in compared to the control in sucrose-loaded SD rat, probably through activation of antioxidants properties in free radical scavenging.


Indeed, tea pomace extract in the study exerted a significant inhibition of intestinal α-glucosidase, in delayed glucose absorption resulting in suppressing postprandial hyperglycemia.

No doubtfully, green tea processed bioactive may be used as a potential nutraceutical product to prevent the risk of hyperglycemia in healthy people and early onset of in people with prediabetes.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials by Liu K1, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, Mi MT.(PubMed)
(2) Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia by Ahmad RS1, Butt MS2, Sultan MT3, Mushtaq Z4, Ahmad S5, Dewanjee S6, De Feo V7, Zia-Ul-Haq M8.(PubMed)
(3) Selected tea and tea pomace extracts inhibit intestinal α-glucosidase activity in vitro and postprandial hyperglycemia in vivo by Oh J1, Jo SH2, Kim JS3, Ha KS4, Lee JY5, Choi HY6, Yu SY7, Kwon YI8, Kim YC9(PubMed)

#Phytochemical #Tartaricacid Shows a Strong Anti-bacterial Activity, Scientists Say

Kyle J. Norton

Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.

Tartaric acid, a phytochemical of the organic acid may be considered an alternative antibiotic remedy to replace conventional medicine for the treatment of infectious diseases caused by harmful bacteria, some studies suggested.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer color.

Out of millions of bacteria present in this world, only a hundred of them cause infectious diseases. And, most bacteria that cause large-scale disease in human history may be closed to extinction.

In contrast to general belief, most bacteria live as independent cells, they share the basic characteristics of all living things, they breathe, metabolize, produce waste, and maintain a membrane potential.

However, bacteria do not process a nucleus in which their DNA is separated from the rest of the cell.

In the differentiation of bacteria, one must know that not all bacteria are bad. Some bacteria found in the digestive tract have been found to aid digestion and prevent the imbalance of bad and good bacteria. In other words, most bacteria are harmless.

Bacteria can enter our body to cause infection through an open wound, drinking bacterially contaminated water, close contact with infectious patients, or breathing in the exhaled droplets of an infected person.

In order to protect the body against bacterial invasion, the immune white blood cells after sensing the presence of harmful pathogens stimulate the production of pro-inflammatory cytokines to the site of infection with an aim to destroy the bacteria before causing damage to the body.

However, overproduction of proinflammatory cytokines in some cases can also cause the death of healthy cells, leading to improper healing with the formation of scars.


Tartaric acid is a phytochemical of the organic acid found abundantly in nuts, apricots, apples, sunflower, avocado, grapes, etc.

In the finding natural antibiotics without inducing side effects as of those in conventional medicine, researchers at the Mississippi State University conducted an experiment to examine the anti-bacterial effects of the water-soluble extracts prepared from purple (cultivar Ison) and bronze (cultivar Carlos) muscadine seeds with or without heating.


Application of the Ison extracts displayed a strong antimicrobial activity against a cocktail of three strains of Escherichia coli O157: H7.

Chemical analysis suggested the extract had a higher acidity (pH 3.39 to 3.43) compared to normal extract.

The major chemical compounds associated with the antibacterial activity include total phenolics (2.21 to 3.49 mg/ml), tartaric acid (5.6 to 10.7 mg/ml), tannic acid (5.7 to 8.1 mg/ml), and gallic acid (0.33 to 0.59 mg/ml), are also higher than those of the Carlos extracts.

Furthermore, heat treatment on both extracts increased antimicrobial activity, possibly because of increased acidity of the tartaric acid, total phenolics, and individual phenolics.

Heating of Ison extracts increased ellagic acid up to 83%. higher than the minimum of 10.7 mg/ml tartaric acid used alone exerted a strong effect against E. coli O157:H7.

However, up to 10.7 mg/ml tartaric acid alone was not as effective against E. coli O157:H7 as were water-soluble seed extracts.

The ingredients that are responsible for the antibacterial efficacy of the purple (cultivar Ison) and bronze (cultivar Carlos) muscadine seeds are tannic and gallic acids, which process the property of inactivation of pathogens.

Dr. Kim TJ, the lead author, on the final phase of the study, wrote, "Water-soluble muscadine seed extracts may be useful for incorporation into juice and other beverage products as natural preservatives"

Taken together, tartaric acid exerted a significant effect in the inhibition of bacterium may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bacterial infection.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) Antimicrobial effect of water-soluble muscadine seed extracts on Escherichia coli O157:H7.

#Turmeric's #Curcumin Inhibit the Risk of Thyroid Cancer by Increasing the Expression of Tumor Suppressor and Decreasing Overexpression of Vimentin, Scientists Suggest

Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells-induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, according to the data from 2013–2015.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.

The thyroid, one of the largest endocrine glands found in the neck, below the Adam's Apple plays an essential role in regulating the use of energy, making proteins, and producing hormones.

Thyroid cancer, the medical condition caused by alternation of the cells in the thyroid gland found 3 times more common in women compared to men, can be classified into 4 most common types
* Papillary thyroid cancer
Papillary thyroid cancer is the most common type of thyroid cancer, accounting for over 80 percent of all cases. It tends to develop in the women's age group between 30-40 years with the tendency to grow slowly.
Papillary thyroid cancer can be treated successfully if diagnosed early.


* Follicular thyroid cancer
Follicular thyroid cancer, the second most common thyroid cancer, accounts for over 15 % of all cases. It is a low-growing cancer with peak onset from ages 40 through 60.
Follicular thyroid cancer can be treated successfully if diagnosed early.

* Medullary thyroid cancer
Medullary thyroid cancer, the third most common thyroid cancer that makes up only 3 percent of all cases, arises from thyroid hormone-producing cells with abnormally high levels of calcitonin. Medullary thyroid cancer tends to grow slowly but it can spread to distant parts of the body, if not treated early.

* Anaplastic thyroid cancer
Anaplastic thyroid cancer is a rare case of thyroid cancer, accounting for less than 2 percent of all cases. It tends to grow and spread very quickly.
Anaplastic thyroid cancer is deadly, with only a 10% survival rate, 3 years after being diagnosed.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of cancer, researchers examined the effect of curcumin on the invasion and metastasis of thyroid cancers.


According to the tested differentiation, curcumin inhibited the multiple metastasis steps of the K1 papillary thyroid cancer cell line.

In a dose-dependent manner, curcumin also suppressed K1 cell viability, attachment, spreading, migration, and invasion abilities.

Furthermore, curcumin could also inhibit the expression and activity of an enzyme associated with cancer cell proliferation.

Based on the findings, researchers said, "Curcumin might be an effective humouristic agent for the treatment of aggressive papillary thyroid carcinomas".

Moreover, in human papillary thyroid carcinoma BCPAP cells, curcumin exerted an anti-thyroid cancer effect by increasing the expression of the tumor suppressor E-cadherin and decreasing the overexpression of vimentin found in various epithelial cancers.

Additionally, curcumin also blocked the activated transforming growth factor -β1 associated with the expression and activity of an enzyme associated with cancer cell proliferation.

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of thyroid cancer, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-β/Smad2/3 signaling pathway by Zhang L1, Cheng X2, Gao Y2, Zhang C3, Bao J2, Guan H4, Yu H2, Lu R5, Xu Q6, Sun Y. (PubMed)
(2) Curcumin inhibits invasion and metastasis in K1 papillary thyroid cancer cells by Zhang CY1, Zhang L, Yu HX, Bao JD, Sun Z, Lu RR. (PubMed)
(3) Thyroid Cancer by Kyle J. Norton

#Sulforaphane (SFN) Isolated from Collard Greens Inhibit Pro-Inflammatory Cytokines Associated with Neuropathic Pain, Researchers Reveal

Kyle J. Norton

Neurological disorders are a class of diseases of the nervous system characterized by structural damage, and biochemical or electrical abnormalities in the brain, spinal cord, or nerves.

Neurodegenerative disease is a type of neurological disorder associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Neuropathic pain is a type of pain that affects the somatosensory nervous system due to damage or disease. Abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia) are some of the most common forms of neuropathic pain found in patients.

There are no obvious causes of neuropathic pain. However, medical conditions such as alcoholism, amputation, diabetes, nerve problems, HIV infection or AIDS, multiple myeloma, multiple sclerosis and shingles, and chemotherapy are some prevalent factors of neuropathic pain.

According to the joint study conducted by the Health Outcomes Practice, there are no published data on the broad prevalence of neuropathic pain (NeP) in the US. However, the 15,751 respondents reported pain (63.7%), of 2,548 data suggested that 10% of Americans may suffer from neuropathic pain (NeP). The rate of NeP in Blacks and Hispanics ethnicity was consistently higher compared to White


Most common treatments of NeP are the use of nonsteroidal anti-inflammatory drugs (44.2%), followed by weak opioids (31.7%), antiepileptics (10.9%), and strong opioids (10.9%).

The most common therapies used for neuropathic pain treatment are physical therapy, relaxation therapy, massage therapy, psychological therapy, and acupuncture accompanied by pain counseling.

Furthermore, in neuropathic pain caused by medical conditions such as diabetes, treatment may emphasize the management of the condition and improvement of quality of life by preventing further nerve damage.

In some cases, an invasive or implantable device may be used to manage the pain.

Collard Green is a species of Brassica Oleracea, belonging to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a potential compound for the treatment of neuropathic pain, researchers investigated sulforaphane (SFN), a derivative of glucoraphanin present in cruciferous vegetables on inflammation-related diseases.

According to the tested analysis, SFN showed an anti-nociceptive effect in a neuropathic pain mouse model, sciatic nerve chronic constriction injury (CCI).

Furthermore, SFN injected intraperitoneally for 7 days inhibited pain behaviors, including mechanical allodynia and thermal hyperalgesia in CCI mice.

Moreover, SFN at a dose-dependently also attenuated CCI-induced pain behavioral hypersensitivity, by inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 that cause neuropathic pain in mice and exhibiting the production of an anti-inflammatory cytokine such as IL-10 associated with pain relief.

More importantly, CCI enhancement of COX2 and iNOS in the induction of nerve injury were also counteracted by the administration of SFN.

Additionally, SFN treatment also increased the CCI-induced increase in µ-opioid receptors that are responsible for the analgesics, in injured sciatic nerves.

Based on the results, researchers said, "SFN has both anti-nociceptive and anti-inflammatory actions"

Taken altogether, collard green processed a high amount of SFN may be considered supplements for the prevention and treatment of neuropathic pain, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice by Wang C1, Wang C. (PubMed)
(2) The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey by Marco D DiBonaventura,1 Alesia Sadosky,2 Kristen Concialdi,1 Markay Hopps,2 Ian Kudel,1Bruce Parsons,2 Joseph C Cappelleri,3 Patrick Hlavacek,2 Andrea H Alexander,2Brett R Stacey,4 John D Markman,5 and John T Farrar. (PMC)