Kyle J. Norton
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Foods stimulated an overgrowth of fungus candida
1. Fruits and artificial ingredients
The high sugar content in fruit feeds Candida except for green apples, citrus, berries, and avocado(186)
and artificial ingredients can depress the immune system(187).
2. Aged cheese(188)
Candida famata found in aged cheese may induce invasive candidiasis(188).
3. Additive and preservation
Men made chemicals can disrupt the digestive track friendly bacteria and allow candida overgrowth(189)(190) such as citric acid. Non-organic food like meat or eggs can also contain antibiotics and steroids for faster growth(191).
4. Alcohol(192)
Alcohol can depress the liver(193) and the immune system(194)(195), causing overgrowth candida.
5. Caffeine, sugar, and sweetener
Caffeine(196)(197), sugar and sweetener(198) all harmful to the body and feed candida
6. Gluten
Gluten is a protein composite that appears in foods processed from wheat and related species
that can cause immune suppression(199)(200)(201).
7. Mushrooms
Mushroom which is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground on soil or on its food source can promote fungus overgrowth(202).
8. Condiments(203)
Condiment which is a sauce or seasoning added to food to impart a particular flavor can depress the immune system(204), causing candida.
9. Vinegar but not apple cider vinegar
Vinegar is an acidic liquid produced from the fermentation of ethanol in a process that yields its key ingredient, an acetic acid which can deplete the stomach of acids and cause inflammation(205)(206) in the digestive tract, including acetic acid ulcer(205).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possess additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(187) Top 4 Most Dangerous Artificial Sweeteners(Fit day)(188) Treatment of Candida famata bloodstream infections: case series and review of the literature. Beyda ND1, Chuang SH, Alam MJ, Shah DN, Ng TM, McCaskey L, Garey KW.(PubMed)
(189) Food Additives And Preservatives(All food business)
(190) Candida Albicans andFood Additives(Candida Albicans cure)(191) Antibiotics exposure, risk factors, and outcomes with Candidaalbicans and non-Candida albicans candidemia. Results from a multi-center study. Wang H1, Wu DW, Han H, Yue JF, Zhang F, Shan TC, Guo HP, Yin M.(PubMed)
(192) Candida and Alcohol Abuse (Holistic health talk)(193) Control of state 3 respiration in liver mitochondria from rats subjected to chronic ethanol consumption. Spach PI1, Cunningham CC. (PubMed)
(194) The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men. Mili F1, Flanders WD, Boring JR, Annest JL, DeStefano F.(PubMed)
(195) Acute immunomodulatory effects of binge alcohol ingestion. Afshar M1, Richards S2, Mann D3, Cross A4, Smith GB5, Netzer G6, Kovacs E7, Hasday J. (PubMed) (196) Recombinagenicity of caffeine for Candida albican . Sarachek A1, Henderson LA. (PubMed)
(197) Effects of growth temperature and caffeine on genetic responses of Candida albicans to ethyl methanesulfonate, nitrous acid, and ultraviolet radiation. Sarachek A, Bish JT. (PubMed)
(198) Sugar, Dairy, Artificial Sweeteners and Candida albicans Infections(Candida Diet Foods)(199) Immunomodulatory strategies for celiac disease. Rossi M1, Maurano F, Luongo D.(PubMed)
(200) The effect of diet on systemic immune responses to wheat gliadin.
Johnson RB, LaBrooy JT, Shearman DJ, Davidson GP. (PubMed)(201) In mice, gluten in maternaldiet primes systemic immune responses to gliadin in offspring.Troncone R1, Ferguson A.(PubMed)(202) [Virulence of the opportunistic pathogen mushroom Candidaglabrata].[Article in Spanish] Castaño I1, Cormack B, De Las Peñas A.(PubMed)
(203) Condiments and the Candida Diet(Jiangsu, Shihuan bioengineer company)(204) Immunomodulation of mast cells by nutrients. Hagenlocher Y1, Lorentz A2. (PubMed)
(205) Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme Q10.
Kohli Y, Suto Y, Kodama T.(PubMed)
Wednesday, 13 September 2023
#CruciferousVeggies' #Sulforaphane (SFN) Inhibits Liver Stress Markers Associated with Liver Toxicity, Researchers Suggest
Kyle J. Norton
Human toxicity is a general term that refers to any substance that causes harm to human health if inhaled, ingested, or absorbed through the skin.
Liver toxicity is a process that causes liver damage by reducing the function of the liver.
Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.
The liver is the largest internal organ that not only filters the blood from the digestive system before passing it to other parts of the body but also plays a critical role in the production of cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers, including transaminases aspartate transaminase (AST) and alanine transaminase (ALT).
Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.
Epidemiologically, drugs that induce liver injury are nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs (anti-tubercular drugs), anti-cancer drugs, hormonal drugs, immunosuppressive agents, and sedative and neuropsychiatric drugs.
Acetaminophen according to a study is the most common form of medication that implicates drug-induced liver injury
However, antibiotics are another class of drugs that cause liver toxicity most commonly
In finding a potent veggie against drug-induced hepatotoxicity, researchers examined sulforaphane (SFN), a thiol compound found in wide abundance in cruciferous plants against acute liver injury.
In VPA-induced liver injury in rats for 7 days, which causes significant biochemical alterations and hepatic histopathological damage, SFN (0.5 mg/kg, orally) for 7 days showed a significant protective effect against liver injury observed by the liver function biomarkers.
More precisely, levels of liver stress markers such as alanine transaminase, aspartate aminotransferase, and alkaline phosphatase were strongly reduced by the administration of SFN.
According to the tested analysis, SFN not only restored serum albumin concentration in a significant manner but also SFN significantly mitigated VPA-induced histopathological alterations.
The efficacy of SFN against liver toxicity was attributed to several mechanisms including inhibition of malondialdehyde and tumor necrosis factor α content associated with oxidative stress and the increase of concomitant increase in hepatic heme oxygenase-1 content and glutathione concentration involved in the antioxidant expression.
Based on the results, researchers wrote, "SFN can significantly ameliorate VPA-induced hepatotoxicity and liver injury primarily by a direct association between antioxidant and anti-inflammatory properties".
Taken altogether, cruciferous plants may be considered supplements for the prevention of acute liver injury, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane protects against sodium valproate-induced acute liver injury by Nazmy EA1, El-Khouly OA1, Atef H2, Said E. (PubMed)
Human toxicity is a general term that refers to any substance that causes harm to human health if inhaled, ingested, or absorbed through the skin.
Liver toxicity is a process that causes liver damage by reducing the function of the liver.
Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.
The liver is the largest internal organ that not only filters the blood from the digestive system before passing it to other parts of the body but also plays a critical role in the production of cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers, including transaminases aspartate transaminase (AST) and alanine transaminase (ALT).
Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.
Epidemiologically, drugs that induce liver injury are nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs (anti-tubercular drugs), anti-cancer drugs, hormonal drugs, immunosuppressive agents, and sedative and neuropsychiatric drugs.
Acetaminophen according to a study is the most common form of medication that implicates drug-induced liver injury
However, antibiotics are another class of drugs that cause liver toxicity most commonly
In finding a potent veggie against drug-induced hepatotoxicity, researchers examined sulforaphane (SFN), a thiol compound found in wide abundance in cruciferous plants against acute liver injury.
In VPA-induced liver injury in rats for 7 days, which causes significant biochemical alterations and hepatic histopathological damage, SFN (0.5 mg/kg, orally) for 7 days showed a significant protective effect against liver injury observed by the liver function biomarkers.
More precisely, levels of liver stress markers such as alanine transaminase, aspartate aminotransferase, and alkaline phosphatase were strongly reduced by the administration of SFN.
According to the tested analysis, SFN not only restored serum albumin concentration in a significant manner but also SFN significantly mitigated VPA-induced histopathological alterations.
The efficacy of SFN against liver toxicity was attributed to several mechanisms including inhibition of malondialdehyde and tumor necrosis factor α content associated with oxidative stress and the increase of concomitant increase in hepatic heme oxygenase-1 content and glutathione concentration involved in the antioxidant expression.
Based on the results, researchers wrote, "SFN can significantly ameliorate VPA-induced hepatotoxicity and liver injury primarily by a direct association between antioxidant and anti-inflammatory properties".
Taken altogether, cruciferous plants may be considered supplements for the prevention of acute liver injury, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane protects against sodium valproate-induced acute liver injury by Nazmy EA1, El-Khouly OA1, Atef H2, Said E. (PubMed)
#Herbal #Turmeric Inhibits Parameters Associated with the Risk of Neuro-degenerative Diseases through Its Antioxidant Activity, Researchers Say
Kyle J. Norton
Scientists may have found a bioactive ingredient for the prevention and treatment of neurodegeneration with no side effects, according to studies.
Neurodegeneration is a condition associated with the gradual loss of neuron function caused by reduced quality and death of the neurons.
Neuroprotection is a process in which medicines or substances are used, including herbal remedy to protect the brain cell integrity against the damage and gradual loss of quality and quantity.
Most cases of neurodegenerative diseases are found in the elderly, including Parkinson's disease, Alzheimer's disease, and Huntington's disease.
According to the statistics, Alzheimer's disease and Parkinson's disease are the most common types of neurodegenerative diseases that affect millions of people worldwide.
In the US, approximately, over five million Americans live with Alzheimer's disease, and at least 500,000 Americans live with Parkinson's disease.
The most common risk factor associated with the onset of neurodegenerative disease is aging. The rise of neurodegenerative disease in the US was probably associated with population-wide health improvements in the increased lifespan, along with a larger generation of aging Americans.
Conventionally, there is no cure for neurodegenerative disease.
The aim of the treatment is to relieve some of the physical or mental symptoms and slow down the progression of the disease accompanied by improving the quality of life of the patients and caregivers.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of neurodegeneration found a high percentage in the elderly, researchers investigated the protective effects of a natural dietary supplement (NDS), containing Curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, on dysmetabolism and neurodegeneration in an animal model.
The experiment included mice-induced neurodegeneration by a high-fat diet (HFD).
NDS treatment mice showed significant prevention of brain lipid accumulation and central insulin resistance by decreasing the cholesterol concentration and increasing the insulin receptor expression and insulin signaling activation.
Furthermore, NDS also protects the brain cell by protecting the function of enzymes FACL-4 (Acyl-CoA synthetase 4), CerS-1, CerS-4 (Ceramides) whose expression was decreased due to a high-fat diet against the onset of neurodegeneration.
Compared to untreated mice, NDS-treated HFD mice attenuated the levels of RNS, ROS, and lipid peroxidation in the brain.
In other words, NDS prevent the accumulation of lipid peroxidation in the neurons, the action can lead to cell death gradually.
Also, in the brain, NDS inhibited the overexpression of proteins associated with pro-infallamtory cytokine and free radicals caused by a high-fat diet in the induction of cell death, compared to untreated mice.
Additionally different of the results, researchers also found that a lower number of apoptotic nuclei was found in cortical sections of NDS-treated HFD mice, compared to untreated mice.
Dr. the lead scientist, after taking into account co and confounders wrote, "The present data indicate that NDS exerts neuroprotective effects in HFD mice by reducing brain fat accumulation, oxidative stress and inflammation and improving brain insulin resistance".
Taken altogether, turmeric used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of neurodegeneration, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration by Di Martino RMC1,2, Bisi A1, Rampa A1, Gobbi S1, Belluti F. (PubMed)
(2) A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice by Nuzzo D1, Amato A2, Picone P3, Terzo S4, Galizzi G5, Bonina FP6, Mulè F7, Di Carlo M. (PubMed)
Scientists may have found a bioactive ingredient for the prevention and treatment of neurodegeneration with no side effects, according to studies.
Neurodegeneration is a condition associated with the gradual loss of neuron function caused by reduced quality and death of the neurons.
Neuroprotection is a process in which medicines or substances are used, including herbal remedy to protect the brain cell integrity against the damage and gradual loss of quality and quantity.
Most cases of neurodegenerative diseases are found in the elderly, including Parkinson's disease, Alzheimer's disease, and Huntington's disease.
According to the statistics, Alzheimer's disease and Parkinson's disease are the most common types of neurodegenerative diseases that affect millions of people worldwide.
In the US, approximately, over five million Americans live with Alzheimer's disease, and at least 500,000 Americans live with Parkinson's disease.
The most common risk factor associated with the onset of neurodegenerative disease is aging. The rise of neurodegenerative disease in the US was probably associated with population-wide health improvements in the increased lifespan, along with a larger generation of aging Americans.
Conventionally, there is no cure for neurodegenerative disease.
The aim of the treatment is to relieve some of the physical or mental symptoms and slow down the progression of the disease accompanied by improving the quality of life of the patients and caregivers.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of neurodegeneration found a high percentage in the elderly, researchers investigated the protective effects of a natural dietary supplement (NDS), containing Curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, on dysmetabolism and neurodegeneration in an animal model.
The experiment included mice-induced neurodegeneration by a high-fat diet (HFD).
NDS treatment mice showed significant prevention of brain lipid accumulation and central insulin resistance by decreasing the cholesterol concentration and increasing the insulin receptor expression and insulin signaling activation.
Furthermore, NDS also protects the brain cell by protecting the function of enzymes FACL-4 (Acyl-CoA synthetase 4), CerS-1, CerS-4 (Ceramides) whose expression was decreased due to a high-fat diet against the onset of neurodegeneration.
Compared to untreated mice, NDS-treated HFD mice attenuated the levels of RNS, ROS, and lipid peroxidation in the brain.
In other words, NDS prevent the accumulation of lipid peroxidation in the neurons, the action can lead to cell death gradually.
Also, in the brain, NDS inhibited the overexpression of proteins associated with pro-infallamtory cytokine and free radicals caused by a high-fat diet in the induction of cell death, compared to untreated mice.
Additionally different of the results, researchers also found that a lower number of apoptotic nuclei was found in cortical sections of NDS-treated HFD mice, compared to untreated mice.
Dr. the lead scientist, after taking into account co and confounders wrote, "The present data indicate that NDS exerts neuroprotective effects in HFD mice by reducing brain fat accumulation, oxidative stress and inflammation and improving brain insulin resistance".
Taken altogether, turmeric used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of neurodegeneration, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration by Di Martino RMC1,2, Bisi A1, Rampa A1, Gobbi S1, Belluti F. (PubMed)
(2) A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice by Nuzzo D1, Amato A2, Picone P3, Terzo S4, Galizzi G5, Bonina FP6, Mulè F7, Di Carlo M. (PubMed)
#Herbal #Ashwagandha Protects the Neurons Against Oxidative Stress-Induced Decrease in DNA Damage of #Glioma Cells
Kyle J. Norton
A glioma is a type of tumor that starts in the glial cells of the brain or the spine.
Glioma cells can be classified into
* Astrocytomas are a type of brain cancer that originates in a particular kind of glial cells, star-shaped brain cells in the cerebrum called astrocytes.
* Ependymomas, are a type of cancer that grows in your brain or any part of the spine, including your neck and upper and lower back.
* Oligodendrogliomas are a type of glioma that starts in glial cells called oligodendrocytes.
Primary glioblastoma is one of the most aggressive cancers that begins within the brain. Cancer may arise as a Grade IV tumor with no evidence.
According to the statistics, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.
In the US, the median age of glioblastoma diagnosed is 64 years and the incidence of the disease onset is 1.6 times higher in males compared to females.
Furthermore, the condition is 2 times higher in Caucasians compared to Africans and Afro-Americans.
Because of the rapid growth, patients diagnosed with primary glioblastoma experience sudden brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, severe headaches, and localized symptoms depending on the location of the tumor.
Conventionally, radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.
The causes of glioblastoma are not identified. However, the increase in age and genetic preposition are the 2 most common risk factors found in patients with the disease.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the inhibition of brain tumors researchers examined the combined active ingredients of Chinese (Helicteres angustifolia) and Indian (Withaniasomnifera) ginseng's effects on glial differentiation potentials.
Based on the tested analysis, the novel combination of Cuc and Wi-N, CucWi-N, showed a significant activity to protect the neuron cells against oxidative stress-induced decrease in DNA damage.
In rat glioblastoma cells, CucWi-N exerted the glial differentiation potential and induced differentiation phenotype.
Proteins are associated with neuron growth and development and a key role in glial differentiation. such as GAP43, MAP2, and GFAP were exhibited by the injection of the combination.
Based on the findings, researchers said, "These data demonstrate anti-stress and glial differentiation potential of CucWi-N (a novel combination of Cuc and Wi-N) that could be recruited in nutraceutical and pharmaceutical avenues and hence warrant further evaluation and mechanistic studies.".
Taken altogether, Ashwagandha may be considered a functional herb that reduces the risk of brain tumors, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence by Garg S1,2, Kaul SC1, Wadhwa R. (PubMed)
A glioma is a type of tumor that starts in the glial cells of the brain or the spine.
Glioma cells can be classified into
* Astrocytomas are a type of brain cancer that originates in a particular kind of glial cells, star-shaped brain cells in the cerebrum called astrocytes.
* Ependymomas, are a type of cancer that grows in your brain or any part of the spine, including your neck and upper and lower back.
* Oligodendrogliomas are a type of glioma that starts in glial cells called oligodendrocytes.
Primary glioblastoma is one of the most aggressive cancers that begins within the brain. Cancer may arise as a Grade IV tumor with no evidence.
According to the statistics, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.
In the US, the median age of glioblastoma diagnosed is 64 years and the incidence of the disease onset is 1.6 times higher in males compared to females.
Furthermore, the condition is 2 times higher in Caucasians compared to Africans and Afro-Americans.
Because of the rapid growth, patients diagnosed with primary glioblastoma experience sudden brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, severe headaches, and localized symptoms depending on the location of the tumor.
Conventionally, radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.
The causes of glioblastoma are not identified. However, the increase in age and genetic preposition are the 2 most common risk factors found in patients with the disease.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the inhibition of brain tumors researchers examined the combined active ingredients of Chinese (Helicteres angustifolia) and Indian (Withaniasomnifera) ginseng's effects on glial differentiation potentials.
Based on the tested analysis, the novel combination of Cuc and Wi-N, CucWi-N, showed a significant activity to protect the neuron cells against oxidative stress-induced decrease in DNA damage.
In rat glioblastoma cells, CucWi-N exerted the glial differentiation potential and induced differentiation phenotype.
Proteins are associated with neuron growth and development and a key role in glial differentiation. such as GAP43, MAP2, and GFAP were exhibited by the injection of the combination.
Based on the findings, researchers said, "These data demonstrate anti-stress and glial differentiation potential of CucWi-N (a novel combination of Cuc and Wi-N) that could be recruited in nutraceutical and pharmaceutical avenues and hence warrant further evaluation and mechanistic studies.".
Taken altogether, Ashwagandha may be considered a functional herb that reduces the risk of brain tumors, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence by Garg S1,2, Kaul SC1, Wadhwa R. (PubMed)
#Antioxidant #Indicaxanthin from Cactus Pear Fruit Processes Anti-Hypercholesterolemia and Anti-Hypercholesterolemic Complications Activities
Kyle J. Norton
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amounts source plays a critical to aiding digestive function in absorbing nutrients, build strong cell membranes, and producing steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hypercholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol, and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people with hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that widespread obesity due to aging may have a strong impact on the increased incidence in the US.
Dr. Parini P, the lead scientist wrote, "Plasma cholesterol levels increase with age, as does the incidence of coronary heart disease" and "the relative deficiency in growth hormone (GH), which occurs with aging, contributes to the development of the age-related hypercholesterolemia, because GH has beneficial effects on cholesterol metabolism".
However, researchers continued, "Growth hormone (GH), treatment strongly reduced the hypercholesterolemia in 18-month-old animals. We conclude that the age-dependent increase of plasma cholesterol in rats can be reversed by the administration of GH, presumably through the pleiotropic effects of this hormone on lipoprotein metabolism".
In other words, aging in the promotion of hypercholesterolemia induced complications can be preventable by the regulation of lipoprotein metabolism.
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains found abundantly in beets, chard, etc.
In finding a potential compound for the improvement of cholesterol file, researchers examined the effect of Indicaxanthin effects on toxic oxysterols in hypercholesterolemia.
Where toxic oxysterols in hypercholesterolemia have been found to cause suicidal death of human erythrocytes or eryptosis associated with red blood cell programmed death.
According to the tested differentiation, indicaxanthin (Ind) from cactus pear fruit, incubated with isolated healthy human erythrocytes exposed to an oxysterol mixture for 48 h in a concentration range (1.0-5.0 μM) prevents membrane phosphatidylserine (PS) externalization and cell shrinkage in a dose-dependent manner.
In other words, indicaxanthin (Ind) protects the PS that regulates the production of thrombin, the central regulatory molecule of blood coagulation caused by overexpression of ROS and depletion of antioxidant enzymes and production of inflammatory cytokine-induced by an oxysterol mixture without affecting the erythrocyte redox environment or other parameters.
In ex vivo, indicaxanthin (Ind) at 5 μm, induced the spiking levels of normal human blood with the oxysterol mixture for 48 h induced eryptosis, by reducing the production of ROS and decreased levels of GSH.
Furthermore, eryptosis, the suicidal erythrocyte death, leads to cell shrinkage and cell membrane scrambling and red blood cell programmed death to cause vascular tissue injury was inhibited by 5 μm-Ind.
These results suggested that eryptotic erythrocytes that contribute to thrombotic complications in hypercholesterolemia were prevented by the application of indicaxanthin.
Based on the findings, researchers said, "the positive effects of diets containing Ind on erythrocytes in hypercholesterolaemic subjects".
Taken altogether, indicaxanthin may be considered a remedy for the prevention of hypercholesterolemia complications, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers by Tesoriere L1, Attanzio A1, Allegra M1, Livrea MA. (PubMed)
(2) Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats by Parini P1, Angelin B, Rudling M. (PubMed)
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amounts source plays a critical to aiding digestive function in absorbing nutrients, build strong cell membranes, and producing steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hypercholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol, and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people with hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that widespread obesity due to aging may have a strong impact on the increased incidence in the US.
Dr. Parini P, the lead scientist wrote, "Plasma cholesterol levels increase with age, as does the incidence of coronary heart disease" and "the relative deficiency in growth hormone (GH), which occurs with aging, contributes to the development of the age-related hypercholesterolemia, because GH has beneficial effects on cholesterol metabolism".
However, researchers continued, "Growth hormone (GH), treatment strongly reduced the hypercholesterolemia in 18-month-old animals. We conclude that the age-dependent increase of plasma cholesterol in rats can be reversed by the administration of GH, presumably through the pleiotropic effects of this hormone on lipoprotein metabolism".
In other words, aging in the promotion of hypercholesterolemia induced complications can be preventable by the regulation of lipoprotein metabolism.
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains found abundantly in beets, chard, etc.
In finding a potential compound for the improvement of cholesterol file, researchers examined the effect of Indicaxanthin effects on toxic oxysterols in hypercholesterolemia.
Where toxic oxysterols in hypercholesterolemia have been found to cause suicidal death of human erythrocytes or eryptosis associated with red blood cell programmed death.
According to the tested differentiation, indicaxanthin (Ind) from cactus pear fruit, incubated with isolated healthy human erythrocytes exposed to an oxysterol mixture for 48 h in a concentration range (1.0-5.0 μM) prevents membrane phosphatidylserine (PS) externalization and cell shrinkage in a dose-dependent manner.
In other words, indicaxanthin (Ind) protects the PS that regulates the production of thrombin, the central regulatory molecule of blood coagulation caused by overexpression of ROS and depletion of antioxidant enzymes and production of inflammatory cytokine-induced by an oxysterol mixture without affecting the erythrocyte redox environment or other parameters.
In ex vivo, indicaxanthin (Ind) at 5 μm, induced the spiking levels of normal human blood with the oxysterol mixture for 48 h induced eryptosis, by reducing the production of ROS and decreased levels of GSH.
Furthermore, eryptosis, the suicidal erythrocyte death, leads to cell shrinkage and cell membrane scrambling and red blood cell programmed death to cause vascular tissue injury was inhibited by 5 μm-Ind.
These results suggested that eryptotic erythrocytes that contribute to thrombotic complications in hypercholesterolemia were prevented by the application of indicaxanthin.
Based on the findings, researchers said, "the positive effects of diets containing Ind on erythrocytes in hypercholesterolaemic subjects".
Taken altogether, indicaxanthin may be considered a remedy for the prevention of hypercholesterolemia complications, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers by Tesoriere L1, Attanzio A1, Allegra M1, Livrea MA. (PubMed)
(2) Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats by Parini P1, Angelin B, Rudling M. (PubMed)
#Lycopene Inhibits Levels of Stress Markers Associated with the Onset of #GastricUlcer through Its Antixodant Activity, Researchers Find
Kyle J. Norton
The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.
The stomach plays a critical role in assisting the digestive system in digesting foods by secreting acid and enzymes.
Gastric or stomach ulcer is a condition of localized tissue erosion in the lining of the stomach.
The most common symptoms of gastric ulcers are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding, unintended weight loss loss of appetite, and gastrointestinal discomforts.
Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.
The imbalance between stomach acid and upper GI tract mucosa is the main cause of the condition onset associated with the use of certain medications, including aspirin, and non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, and chronic gastritis.
Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation and critical illness are at an increased risk of gastric ulcer.
Dr. Haruka Fujinami lead scientist in the examination of long-term intake of conventional medicine in the risk of gastric ulcer wrote, "The rates of Helicobacter pylori (H. pylori) infection were significantly low (P = 0.039), while the proportion of nonsteroidal anti-inflammatory drugs (NSAIDs) users and vascular disease significantly increased over the period studied (P = 0.034 and P = 0.04, respectively)".
And, "It’s found that the primary cause of peptic ulcer bleeding changed from H. pylori infection to use of NSAIDs over the 7-year period of study. It seems that the number of low-dose aspirin users has increased with the increase in the proportion of vascular disease".
The results strongly suggested if you are a long-term user of nonsteroidal anti-inflammatory drugs, your risk of gastric ulcer is significantly higher.
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential compound for the treatment of ulcers, researchers examined the protective effects of lycopene on an indomethacin-induced gastric ulcer model.
The study included a total of 42 adult male Wistar rats induced by gastric ulcer by divided into six groups of seven animals as follows: control, indomethacin, lansoprazole, lycopene 10 mg/kg, lycopene 50 mg/kg and lycopene 100 mg/kg.
According to the tested analysis, the % Tail DNA and Mean Tail Moment in the gastric ulcer group were significantly decreased by the treatment of lycopene at the dose of 100 mg/kg, compared to other treatment groups.
Furthermore, the treatment of lycopene at the dose of 100 mg/kg not only decreased the increased levels of malondialdehyde and myeloperoxidase in the gastric ulcer group but also increased the antioxidant enzymes in the gastric tissue without affecting the levels of catalase.
Based on the findings, researchers said, "lycopene might have a protective effect against indomethacin-induced gastric ulcer and oxidative stress in rats".
Taken together, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of gastric ulcer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats by Boyacioglu M1, Kum C2, Sekkin S2, Yalinkilinc HS2, Avci H3, Epikmen ET3, Karademir U. (PubMed)
(2) A study of the changes in the cause of peptic ulcer bleeding by Haruka Fujinami, Takahiko Kudo, Ayumu Hosokawsa, Kohei Ogawa, Takako Miyazaki, Jun Nishikawa, Shinya Kajiura, Takayuki Ando, Akira Ueda, and Toshiro Sugiyama. (PMC)
The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.
The stomach plays a critical role in assisting the digestive system in digesting foods by secreting acid and enzymes.
Gastric or stomach ulcer is a condition of localized tissue erosion in the lining of the stomach.
The most common symptoms of gastric ulcers are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding, unintended weight loss loss of appetite, and gastrointestinal discomforts.
Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.
The imbalance between stomach acid and upper GI tract mucosa is the main cause of the condition onset associated with the use of certain medications, including aspirin, and non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, and chronic gastritis.
Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation and critical illness are at an increased risk of gastric ulcer.
Dr. Haruka Fujinami lead scientist in the examination of long-term intake of conventional medicine in the risk of gastric ulcer wrote, "The rates of Helicobacter pylori (H. pylori) infection were significantly low (P = 0.039), while the proportion of nonsteroidal anti-inflammatory drugs (NSAIDs) users and vascular disease significantly increased over the period studied (P = 0.034 and P = 0.04, respectively)".
And, "It’s found that the primary cause of peptic ulcer bleeding changed from H. pylori infection to use of NSAIDs over the 7-year period of study. It seems that the number of low-dose aspirin users has increased with the increase in the proportion of vascular disease".
The results strongly suggested if you are a long-term user of nonsteroidal anti-inflammatory drugs, your risk of gastric ulcer is significantly higher.
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential compound for the treatment of ulcers, researchers examined the protective effects of lycopene on an indomethacin-induced gastric ulcer model.
The study included a total of 42 adult male Wistar rats induced by gastric ulcer by divided into six groups of seven animals as follows: control, indomethacin, lansoprazole, lycopene 10 mg/kg, lycopene 50 mg/kg and lycopene 100 mg/kg.
According to the tested analysis, the % Tail DNA and Mean Tail Moment in the gastric ulcer group were significantly decreased by the treatment of lycopene at the dose of 100 mg/kg, compared to other treatment groups.
Furthermore, the treatment of lycopene at the dose of 100 mg/kg not only decreased the increased levels of malondialdehyde and myeloperoxidase in the gastric ulcer group but also increased the antioxidant enzymes in the gastric tissue without affecting the levels of catalase.
Based on the findings, researchers said, "lycopene might have a protective effect against indomethacin-induced gastric ulcer and oxidative stress in rats".
Taken together, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of gastric ulcer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats by Boyacioglu M1, Kum C2, Sekkin S2, Yalinkilinc HS2, Avci H3, Epikmen ET3, Karademir U. (PubMed)
(2) A study of the changes in the cause of peptic ulcer bleeding by Haruka Fujinami, Takahiko Kudo, Ayumu Hosokawsa, Kohei Ogawa, Takako Miyazaki, Jun Nishikawa, Shinya Kajiura, Takayuki Ando, Akira Ueda, and Toshiro Sugiyama. (PMC)
#Cranberry Combined with #Dandelion Reduce Symptoms and Improve Key Indicators of Renal Failure in Chronic Kidney Disease (CKD), Researchers Reveal
Kyle J. Norton
The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.
In other words, kidney disease often has no symptoms until a very advanced stage.
Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in a high number of patients with diabetes, high blood pressure, and other disorders.
Acute kidney dysfunction or acute kidney failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidney dysfunction can be cured if the causes are found.
Most cases of acute kidney dysfunction may be associated with toxins accumulated in the kidney organs, leading to the condition of nephrotoxicity.
Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or overdose of certain medications.
Some researchers suggested that people with diabetes are at an increased risk of chronic kidney disease, particularly in those with hyperglycemia.
The National Kidney Foundation wrote, "Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. The strict control of blood sugar levels and reduction of dietary protein intake is also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of renal disease, researchers examined the effect of Vaccinium macrocarpon (Cranberry)and Taraxacum officinale (Dandelion) on spontaneous feline chronic kidney disease.
The study included 34 neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) containing 60-80% hydrolyzed proteins, 20-40% minerals and active substances (Lespedeza spp. 0.0588, Vaccinium macrocarpon 0.0371%, and Taraxacum officinale 0.0231%.) for 90 days.
According to the tested analysis, both showed a significant effect on the reduced symptoms.
Cats that received the ND exerted a significant decrease in creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase. The elevated levels of the aforementioned parameters have been found persistently in patients with chronic kidney disease.
Furthermore, urine turbidity score, color score, and total proteins associated with the progression of CKD in cats that received the ND were also decreased substantially.
Collectively, researchers after taking other factors into account said, "An ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CKD, particularly in combination with dandelion and Lespedeza spp, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberries - potential benefits in patients with chronic kidney disease by de Almeida Alvarenga L 1, Borges NA, Moreira LSG, Resende Teixeira KT, Carraro-Eduardo JC, Dai L, Stenvinkel P, Lindholm B, Mafra D. (PubMed)
(2) A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease by Di Cerbo A1,2, Iannitti T3, Guidetti G4, Centenaro S4, Canello S5, Cocco R. (PubMed)
(3) DIABETES AND CHRONIC KIDNEY DISEASE by The National Kidney Foundation
The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.
In other words, kidney disease often has no symptoms until a very advanced stage.
Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in a high number of patients with diabetes, high blood pressure, and other disorders.
Acute kidney dysfunction or acute kidney failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidney dysfunction can be cured if the causes are found.
Most cases of acute kidney dysfunction may be associated with toxins accumulated in the kidney organs, leading to the condition of nephrotoxicity.
Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or overdose of certain medications.
Some researchers suggested that people with diabetes are at an increased risk of chronic kidney disease, particularly in those with hyperglycemia.
The National Kidney Foundation wrote, "Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. The strict control of blood sugar levels and reduction of dietary protein intake is also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of renal disease, researchers examined the effect of Vaccinium macrocarpon (Cranberry)and Taraxacum officinale (Dandelion) on spontaneous feline chronic kidney disease.
The study included 34 neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) containing 60-80% hydrolyzed proteins, 20-40% minerals and active substances (Lespedeza spp. 0.0588, Vaccinium macrocarpon 0.0371%, and Taraxacum officinale 0.0231%.) for 90 days.
According to the tested analysis, both showed a significant effect on the reduced symptoms.
Cats that received the ND exerted a significant decrease in creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase. The elevated levels of the aforementioned parameters have been found persistently in patients with chronic kidney disease.
Furthermore, urine turbidity score, color score, and total proteins associated with the progression of CKD in cats that received the ND were also decreased substantially.
Collectively, researchers after taking other factors into account said, "An ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CKD, particularly in combination with dandelion and Lespedeza spp, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberries - potential benefits in patients with chronic kidney disease by de Almeida Alvarenga L 1, Borges NA, Moreira LSG, Resende Teixeira KT, Carraro-Eduardo JC, Dai L, Stenvinkel P, Lindholm B, Mafra D. (PubMed)
(2) A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease by Di Cerbo A1,2, Iannitti T3, Guidetti G4, Centenaro S4, Canello S5, Cocco R. (PubMed)
(3) DIABETES AND CHRONIC KIDNEY DISEASE by The National Kidney Foundation
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