#Phytochemical #Sinigrin Inhibits Proteins Associated with Inflammation and #ImmuneResponse, Researchers Say

Kyle J. Norton

Sinigrin may be used as a dietary supplement for the improvement of the antioxidant profile in patients with overexpression of reactive oxygen species (ROS), according to studies.

ROS, a phrase used to describe a number of reactive molecules. Free radicals are unstable molecules with unpaired electrons on the outer ring. In order for them to become stable, free radicals are ready to donate or intercept an electron from other stable atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.

Reactive Oxygen Species (ROS) have long been known to be a component that impairs the function of the response of immune cells to microbial invasion and induces cytotoxicity in healthy cells, leading to the damage of lipids, proteins, and alternation of cell DNA.

In other words, overexpression of ROS can cause tissue and DNA damage, causing chronic diseases such as cardiovascular and inflammatory disease, cataracts, and cancer.


Free radicals can be produced by either cell metabolism or contact with outside sources, including the food and air we breathe.

In healthy individuals, free radicals are neutralized by the antioxidant enzymes produced by the body's defense system. People with low levels of antioxidant enzymes can acquire antioxidants from dietary sources found in fruits and vegetables.

In fact, free radicals play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. Free radicals can exert beneficial effects on cellular responses and immune function at low levels. However, at high concentrations, free radicals generate oxidative stress, a deleterious process that can damage all cell structures.


Antioxidants are stable molecules that inhibit free radicals.

Sinigrin is a phytochemical glucosinolate, that belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Scientists on finding a natural compound that processes a strong antioxidant activity against oxidative stress examined by the effect of sinigrin anti-free radicals activity.

Sinigrin enhanced the immune macrophage function, by enhancing the activity of Nod-like receptor protein 3 (NLRP3) against cell stress.

The chemical compound also inhibited the expression of free radicals on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in a concentration-dependent manner.

Sinigrin also exhibited anti-inflammatory activity against the expression of COX-2 and prostaglandin E2 (PGE2) in RAW 264.7 cells and proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6.

Treatment with sinigrin decreased pro-inflammatory expression (IL-1β and IL-18) and concurrently suppressed NLRP3, the protein associated with innate immune response and inflammation.

In other words, by blocking the expression of NLRP3, sinigrin inhibited the pro-inflammatory expression (IL-1β and IL-18).


Furthermore, the efficacy of sinigrin immunomodulatory activity was attributed to the decreasing activation of the signaling in the activation of pro-inflammatory pathways such as the NF-κB/MAPK pathways or NLRP3 inflammasome.

The findings strongly suggested that sinigrin has immunomodulatory effects by suppressing the production of inflammatory mediators.

Taken altogether, sinigrin may be considered an antioxidant supplement for modulatory activity against oxidative stress in the induction of inflammation.

However, the intake of sinigrin should be taken with extreme care to prevent acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin and Its Therapeutic Benefits by Mazumder A1, Dwivedi A2, du Plessis J. (PubMed)
(2) Sinigrin inhibits the production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages by Lee HW1, Lee CG1, Rhee DK1, Um SH2, Pyo S. (PubMed)
(3) Free Radicals, Antioxidants in Disease and Health by Lien Ai Pham-Huy,1 Hua He, and Chuong Pham-Huy. (PMC)

Garlic Powder Tablets are More Effects in Treating Hypertension Compared to Regular Garlic Supplements, Researchers Say

Kyle J. Norton

Scientists may have found a bioactive ingredient that can normalize blood pressure without inducing any side effects, according to studies.
Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

High blood pressure is a condition of abnormally high blood pressure, leading to rising pressure in your heart.

If it stays high over time it can cause hardening and stiffening arterial walls,, a major risk factor for heart diseases.

The ideal blood pressure is more than 120 over 80 and less than 140 over 90 (120/80-140/90), according to the consensus.

Abnormal high blood pressure, depending on how high the numbers, patients may experience symptoms of a headache to severe headache., fatigue, and vision problems. However, in severe cases, high blood pressure can also induce chest pain, difficulty breathing, irregular heartbeat, and confusion.

Untreated high blood pressure, epidemiologically can cause complications of retinopathy, lead to damage to the retina or bleeding in the eye, blurred vision, and complete loss of vision.


Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidneys.

If you can control your diet, such as making changes to your lifestyle, maintaining an ideal weight, and dieting with low salt, you could do just fine without the drugs.

The hypertension clinical guideline from the National Institute for Health and Clinical Excellence (NICE) usefully recommends regular aerobic exercise and reduction of salt, alcohol, and smoking, and advocates ‘healthy, low-calorie diets' for ‘overweight individuals with raised blood pressure'".

This suggestion once again, highlighted that high blood pressure can be prevented by a change to a healthy lifestyle.

In finding a natural ingredient for the prevention and treatment of high blood pressure with no side effects, scientists at the Clinical Research Center looked into the antihypertensive effect of a popular garlic preparation containing 1.3% allicin at a large dose (2400 mg).

Nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg) were included in the study.

Application of the preparation reduced the sitting blood pressure by 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, with a significant decrease in diastolic blood pressure (p < 0.05) from 5-14 hours after the dose.
No significant side effects were reported. The findings strongly indicate that this garlic preparation can reduce blood pressure.

Furthermore, in order to compare the antihypertensive effect of the different fractions of garlic, researchers investigated the hypotensive action of time-released garlic powder tablets (Allicor) vs. regular garlic pills (Kwai).


84 men with mild or moderate arterial hypertension participated in the study.

After an 8-week placebo treatment run-in phase, patients were randomized either to 600 mg Allicor (n=30) or to placebo (n=20) daily for 8 weeks. In addition, in the open-label branch, patients received either 2400 mg Allicor daily (n=18) or 900 mg Kwai daily (n=16).


Allicor treatment (600 mg daily) resulted in a reduction of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively. Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit.
Treatment with Kwai resulted in the same decrease in systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as that seen with Allicor, but no decrease in diastolic blood pressure.

In the depth analysis, researchers found that different effects of Allicor and Kwai on diastolic blood pressure may be associated with the prolonged action of Allicor.


Dr. Sobenin IA, wrote in the final report, "The results of this study show that time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements".

Taken together,. allicin, a bioactive compound of garlic may be used for the prevention and treatment of high blood pressure with no side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Can garlic lower blood pressure? A pilot study by McMahon FG, Vargas R.(PubMed)
(2) Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension by Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. (PubMed)
(3) Hypertension and lifestyle modification: how useful are the guidelines? by Rachel Nicoll. (PMC)

#Coffee Caffeine Intake During Pregnancy Does Not Associate with Poor Child Cognition and Behavior, Researchers Suggest

Kyle J. Norton

Epidemiological studies do not agree that maternal Caffeine Intake during pregnancy may have a negative impact on child cognition and behavior, a new study suggested.

Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

Cognition and Behavior is a group of neuron functions involving sensation and perception, learning and memory, attention, mental imagery, conceptual presentation, language expression, emotion response, motor control,.....

In the study of examining maternal serum paraxanthine at <20 and ≥26 weeks gestation with the child's intelligence quotient (IQ) and problem behaviors at ages 4 and 7 years among 2,197 mother-child pairs, researchers showed that paraxanthine, a structurally related to caffeine.and caffeine's primary metabolite concentration has a significantly inverted effect at ≥26 weeks gestation with child's IQ at age 7 years.

At <20 weeks, paraxanthine also expressed a linearly associated with internalizing behavior at age 4 years.

Interestingly, after taking into account a range of values applicable to most pregnant women, researchers indicated that coffee caffeine in contribution to serum paraxanthine concentration showed no significant effect in association with childhood IQ or problem behaviors.

In contrast to the healthy mothers, Women's reported coffee intake per day during pregnancy was associated with lower child's Behavior Rating Scale (BRS), a complete overview of child and adolescent concerns and disorders, ratings in anemic children. Even with the inclusion of other contributing factors and after anemic children were given appropriate treatment, coffee consumption continuously showed Poor Child Cognition and Behavior.

Dr.Engle PL, the lead author said, " The effects of postnatal coffee ingestion in Guatemala were seen for sleep duration, but not for cognitive development. Prenatal coffee ingestion was negatively associated with Behavior Rating Scales".

Taking together, coffee caffeine intake during pregnancy may not have any meaningful effect in association with childhood cognitive development and measurement of Behavior Rating Scales, excluding anemic children,


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age by Klebanoff MA, Keim SA.(PubMed)
(2) Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep by Engle PL1, VasDias T, Howard I, Romero-Abal ME, Quan de Serrano J, Bulux J, Solomons NW, Dewey KG.(PubMed)

#AITC-rich Mustard Seed Powder (MSP-1) Processes Anti #BladderCancer Activity, Scientists Reveal

Kyle J. Norton

Phytochemical Sinigrin may be used as a natural ingredient for the treatment of bladder cancer, according to studies.

Bladder cancer is a medical condition characterized by cell growth uncontrollably in the bladder tissue, due to the alternation of DNA.

Most cases of bladder cancer start in the cells of the inner lining of the bladder tissue. At the early, due to the small size and on the surface of the inner lining, most patients do not experience any symptoms.

However, at the advanced stage, the larger size tumor may press on the nearby blood vessels and nerve cells, leading to the symptoms of a burning sensation, blood in the urine, abnormal urinary activity, particularly, severe abdominal pain and back pain on one side of the body.

If you experience some of the symptoms, please check with your doctor to rule out the possibility of bladder cancer.

Also, at this stage, the cancer cells can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

Epidemiologically, smoking, the increase in age, chronic bladder inflammation, and long-term exposure to toxic chemicals are the most prevalent risk factors for bladder cancer.

Recently, some researchers have started to question the risk of bladder cancer in the obese population.

Dr. Qin Q. wrote, "A total of 11 cohort studies were included in our meta-analysis, which showed that obesity was associated with an increased risk for bladder cancer in all subjects (RR=1.10, 95% CI=1.06-1.16; p=0.215 for heterogeneity; I2=24.0%). Among the 9 studies that controlled for cigarette smoking, the pooled RR was 1.09 (95% CI 1.01-1.17; p=0.131 for heterogeneity; I2=35.9%)"

Compared to the RR ratio, obesity, and cigarette smoking shared an extremely close ratio of 1.09 and 1.10 respectively. In other words, if you are obese, your risk of bladder cancer is 0.01 higher compared to smokers.

Sinigrin is a phytochemical glucosinolate, that belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on finding a bioactive compound for the treatment of bladder cancer examined the effects of AITC-rich mustard seed powder (MSP-1) with AITC stably stored as its glucosinolate precursor (sinigrin) in MSP-1.


In a rat model, hydrated MSP-1 caused apoptosis and G(2)/M phase arrest in bladder cancer cell lines in vitro.

In the comparison of cancer activity between hydrated MSP-1 and pure sinigrin with added myrosinase, researchers surprisingly found that the anticancer effect of MSP-1 was derived principally, if not entirely, from the AITC generated from sinigrin.


In an orthotopic rat bladder cancer model, oral MSP-1 at 71.5 mg/kg (sinigrin dose of 9 μmol/kg) inhibited bladder cancer growth by 34.5% (P < 0.05) and blocked muscle invasion by 100%.

The in-depth analysis suggested that the anti-bladder cancer efficacy of MSP-1 was attributed to significant modulation of key cancer therapeutic targets, including blocking the vascular endothelial growth factor in the generation of the new blood vessels to promote cancer growth, a cyclin-associated cancer cell division and caspase correlated with significantly increased rate of cancer recurrence and deaths.

Furthermore, the anticancer activity of AITC delivered as MSP-1 appears to be more robust compared to that of pure AITC.
The finding strongly suggested that MSP-1 exhibited the AITC in the inhibition of bladder cancer development and progression.

Moreover, in the investigation of the effect of various dose levels of AITC on the activities of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST) in rat tissues, researchers conducted an experiment with the selected rat given high and low dose level of AITC daily for 5 days.

At low doses, AITC increased the production of antioxidant enzyme activity observed only in the urinary bladder of the rats, at a dose of AITC of only 10 micromol/kg/day.


In the activities of phase II, detoxification enzyme quinone reductase (QR), a plateau of activity of rats given the injection AITC for 21 days was reached after 15 daily doses of AITC, but GST activity continued to increase with continued exposure, and no plateau was reached after 21 doses.

Further examination of the levels of enzymes in the treated rats, researchers surprisingly found that the dose level of AITC is effective in rats approaches the level that could only be achieved through human consumption of Brassica.

The results strongly support the use of dietary approaches for the prevention and treatment of bladder cancer. Dr. the lead scientist said, "Induction of phase II enzymes by food-derived isothiocyanates could contribute to the lower incidence of bladder cancer observed in individuals who regularly consume such vegetables".

Taken altogether, sinigrin, a bioactive ingredient found in the Brassica may be considered a supplement for the prevention and treatment of bladder cancer, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion by Bhattacharya A1, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y. (PubMed)
(2) Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables by Munday R1, Munday CM. (PubMed)
(3) Obesity and risk of bladder cancer: a meta-analysis of cohort studies by Qin Q1, Xu X, Wang X, Zheng XY. (PubMed)

#Hexane Extract foudn in #Turmeric Inhibits Hair Loss and Improves Hair Growth, Researchers Say

Kyle J. Norton

Every day the scalp loses about 100 hairs and they will grow back in 5-6 weeks. However, in older men, hair loss was associated with the increase of levels of by-product prolactin of testosterone-induced the conversion of testosterone to dihydro-testosterones DHT, a leading cause in the promotion of hair growing back thinner or not growing back at all.
The presence of dihydro-testosterones DHT shrinks the follicles causing hair to thin and recede at the forehead, crown, and temple for men and thin over the entire scalp for women.

There are many factors involved in the loss of hair. Aging, nutrient deficiency, genetic proposition, smoking, and an unhealthy diet are some of the most common risk factors that cause hair loss in the Western world.

Conventionally, Minoxidil, a topical medicine approved by The U.S. Food and Drug Administration (FDA) was found to stop hairs from getting thinner and stimulate hair growth on the top of the scalp with a number of side effects.

Dr. Rossi A, the lead scientist at the University Sapienza of Rome in the evaluation of the effects of
oral Minoxidil wrote, " Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes and it is also a vasodilator, it is speculated that, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicle".

And, "The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp. There have been cases of allergic reactions to the nonactive ingredient propylene glycol, which is found in some topical solutions especially if they are galenic".

Therefore, if you are using the aforementioned product for the treatment of hair loss, please make sure you know all the side effects for preventive measures.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential ingredient for the treatment of hair loss, researchers evaluated the efficacy of 5% hexane extract of Curcuma aeruginosa (turmeric), a botanically derived inhibitor of 5α-reductase and 5% minoxidil in the treatment of androgenetic alopecia.

The study included 87 men with androgenetic alopecia (AGA) randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months.

According to the tested assay, the combined treatment group showed statistically significant improvements in hair regrowth, and hair shedding in a global photographic review of all subjects, compared to the single treatment of groups and placebo.

In other words, treatment with 5% minoxidil and 5% C. aeruginosa extract showed some degrees of hair regrowth without affecting hair shedding.

No adverse effects were found during the course of the experiment.

Based on the results, researchers wrote in the final report, "In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth".

Taken together, turmeric used alone or combined with minoxidil may be considered supplements for the prevention and treatment of alopecia areata, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study by Pumthong G1, Asawanonda P, Varothai S, Jariyasethavong V, Triwongwaranat D, Suthipinittharm P, Ingkaninan K, Leelapornpisit P, Waranuch N. (PubMed)
(2) Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells by Srivflai J, Khorana N, Waranuch N, Wisuitiprot W, Suphrom N, Suksamrarn A, Ingkaninan K. (PubMed)
(3) Minoxidil use in dermatology, side effects and recent patents by Rossi A1, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. (PubMed)

#Lycopene Exerts Strong Cardio and Nephroprotective Effects through Its Inhibiting Oxidativestress Markers, According to Studies

Kyle J. Norton

Nephrotoxicity is toxicity in the kidneys associated with reduced function of the kidney due to toxic chemicals, and medications.

The kidneys are essential bean-shaped organs of our body, located just below the rib cage, one on each side of your spine.

Kidneys play a critical role in filtering blood with billions of glomeruli by separating the cells of blood from plasma and reabsorbing back substances, and secret waste such as urea and ammonium are stored in the pelvis and then into the ureter to the bladder.

Furthermore, kidneys also process the functions that regulate electrolytes, and blood pressure, maintain acid-base balance, produce hormone calcitriol, renin, and erythropoietin, etc.

In the urinary system, the kidney also reabsorbed substances into the blood, while other wastes, such as urea and ammonium are stored in the pelvis and then into the ureter to the bladder.

The most common symptoms of nephrotoxicity are decreased urine output, fluid retention, causing swelling in your legs, ankles, or feet, weakness, fatigue, and irregular heartbeat.

In severe cases, patients may also experience symptoms of shortness of breath and confusion.

Cardiotoxicity, on the other hand, is toxicity in the heart associated with reduced heart muscle capacity in the blood circulation due to toxic chemicals, and medications.

The heart, a four-chambered, hollow muscle and double-acting pump that is located in the chest between the lungs is a muscular organ in the human body that processes the function that pumps blood through the blood vessels of the circulatory system to nourish the body and assists in the removal of metabolic wastes.

According to the statistics provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. In 2016, cardiovascular diseases caused the death of 2,303 deaths each day, in the US.

Compared to nephrotoxicity, patients with cardiotoxicity may have symptoms of fatigue, shortness of breath on exertion, worsening to shortness of breath at rest, discomfort lying on your back, and swelling of the ankles.


Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

Researchers examined the effects of lycopene against the toxic effects of Aflatoxin B1(AFB1) exposure in the kidney and heart of experimental rats.

A total of 42 healthy three-month-old male Wistar-Albino rats were randomly divided into six experimental groups including 7 rats in each as following control group, lycopene (5 mg/kg/day, orally for 15 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) group, AFB1 (1.5 mg/kg/day, orally for 3 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) + lycopene (5 mg/kg/day, orally for 15 days) group and AFB1(1.5 mg/kg/day, orally for 3 days) + lycopene (5 mg/kg/day, orally for 15 days) group.

Compared to AFB1 and according to the tested analysis, the elevated levels of malondialdehyde (MDA) levels associated with oxidative stress markers were significantly decreased in the lycopene treatment group.

The reduced levels of antioxidant enzymes in the AFB1 group such as glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glucose-6-phosphate-dehydrogenase (G6PD) activities were increased substantially in kidney and heart tissues upon the injection of lycopene.

Furthermore, the non-enzymatic antioxidant system in AFB-treated rats that caused the rise of oxidative stress in the rat kidney and heart was also inhibited by the administration of lycopene.

Moreover, lycopene also inhibited the increased urea, and creatinine levels, and reduced sodium concentrations in the plasma of AFB1-treated rats.

Based on the findings, researchers said, "Their lycopene showed protection against AF-induced nephrotoxicity and cardiotoxicity".

Taken together, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of osteoporotic fractures, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment by Anjos Ferreira AL1, Russell RM, Rocha N, Placido Ladeira MS, Favero Salvadori DM, Oliveira Nascimento MC, Matsui M, Carvalho FA, Tang G, Matsubara LS, Matsubara BB. (PubMed)

#CruciferousVegetables Lower the Odds of Experiencing Symptoms of Menopause in #BreastCancer Survivors, Researchers Suggest

Kyle J. Norton

Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

The development of cancer can be divided into three different stages
* Initiation
Initiation is characterized by the irreversible mutation of DNA of a particular cell which does not undergo DNA repair (by enzymes) or undergoes faulty DNA repair, including gene deletion or insertion, gene slices, etc.

* Promotion
In the promotion stage, the mutation cells are involved in the uncontrolled growth and proliferation of mutated cells as it promotes the expression of its mutation gene and in its replication. In time these cells lose their normal abilities and just reproduce.

* Progression
In the progression stage, the cancerous cells invade nearby tissues and migrate to other tissues via lymph or blood

Breast cancer is a medical condition characterized by irregular cell growth in the breast tissues. At the late stage, the cancerous cells may travel a distance away to infect other organs and tissues from the original site.

The study of bioactive green tea polyphenol epigallocatechin-3-gallate (EGCG) was found to decrease the progression of breast cancer cells with Her-2/neu overexpression, through many mechanisms.

Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.

In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone, or genetic preposition.

Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive and can grow and spread quickly to other tissues and organs through lymph and blood.

Also compared to other breast cancers, with decreased risk after 5 years, triple-negative breast cancers have a substantially higher recurrent rate within 5 years after treatment.


Triple-negative breast cancer shares symptoms similar to those of breast cancer and risk factors except in the form of the genetic preposition.


Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

In finding a potential compound for the treatment of cancer, researchers examined the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors.

The joint cross-sectional study led by Georgetown University included 192 CA and 173 NHW female breast cancer survivors (stages 0-III, diagnosed between 2006 and 2012) recruited from two California cancer registries, who had completed primary treatment.


Based on the Patient-reported data on treatment-related symptoms and potential covariates collected via telephone interviews, *

 Soy foods and cruciferous vegetable intake ranged from no intake to 431 and 865 g/day, respectively, and was higher in CA survivors.

* Higher soy food intake was associated with lower odds of menopausal symptoms (≥ 24.0 vs. 0 g/day, OR 0.51, 95% CI 0.25, 1.03), and fatigue (≥ 24.0 vs. 0 g/day, OR 0.43, 95% CI 0.22, 0.84), particularly in NHW survivors only.

* Compared with low intake, higher cruciferous vegetable intake was associated with lower odds of experiencing menopausal symptoms (≥ 70.8 vs. < 33.0 g/day, OR 0.50, 95% CI 0.25, 0.97) in the overall population.

Taken altogether, cruciferous vegetables may be considered functional foods for the treatment of breast cancer survivors' menopausal symptoms and fatigue, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese-American and non-Hispanic White breast cancer survivors by Nomura SJO1, Hwang YT2, Gomez SL3, Fung TT4,5, Yeh SL6, Dash C1, Allen L3, Philips S7, Hilakivi-Clarke L1, Zheng YL1, Wang JH. (PubMed)