Kyle J. Norton
Kidneys are 2 bean-shaped organs found on the left and right side of the retroperitoneal space in the body.
The function of the kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.
Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.
Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.
Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.
Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.
The disease is caused by the poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.
According to the American Physician Association, long-term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs, and rifampicin are associated with increased damage to the kidney.
And people aged over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.
Oxidative nephrotoxicity is a condition of kidney damage caused by overexpression of free radicals compared to levels of antioxidants.
Dr. Keiko Hosohata in the examination "Role of Oxidative Stress in Drug-Induced Kidney Injury",
Said, "Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury".
"In fact, drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20% of cases of acute kidney injury (AKI) among hospitalized patients".
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of kidney diseases, researchers examined the nephroprotective effects of 6-hydroxy-1-methylindole-3-acetonitrile (6-HMA), which was isolated from the roots of B. rapa, on cisplatin-induced toxicity in renal epithelial LLC-PK1 cells and in rats with acute renal injury
The study included 16 subjects who were randomized, and 15 subjects completed all visits.
According to the tested analysis, in vitro and Vivo
* The pretreatment of LLC-PK1 cells with 6-HMA ameliorated cisplatin-induced cytotoxicity caused by oxidative stress.
* The pretreatment also decreased the levels of reactive oxygen species (ROS) and kidney stress marker malondialdehyde (MDA) and increased levels of glutathione (GSH).
* Furthermore, 6-HMA inhibited cisplatin-induced heme oxygenase-1 (HO-1) expression involved in oxidation and inflammation by the binding activity of NF-E2-related factor 2 (Nrf2), the antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
* Moreover, 6-HMA-administered rats showed lower levels of blood urea nitrogen (BUN), creatinine, and urinary lactate dehydrogenase (LDH) associated with kidney damage than cisplatin alone-treated rats in the cisplatin-induced renal injury model.
* Additionally, 6-HMA inhibited the cisplatin-induced formation of MDA and GSH depletion and increased the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR).
Based on the results, researchers wrote, " these findings indicate 6-HMA is a major active constituent from the roots of B. Rapa to have a protective effect against cisplatin-induced nephrotoxicity by attenuating oxidative stress.".
Taken altogether, Brassica rapa processed abundantly 6-HMA may be considered supplements for the prevention of oxidative nephrotoxicity, ending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation by Moon JH1, Shin JS, Kim JB, Baek NI, Cho YW, Lee YS, Kay HY, Kim SD, Lee KT. (PubMed)
(2) Role of Oxidative Stress in Drug-induced Kidney Injury by Keiko Hosohata. (PMC)
Saturday, 9 September 2023
#Turmeric Inhibits #Psoriasis through Its Immune Modulation and Anti-Inflammatory Therapy
Kyle J. Norton
Psoriasis is a skin condition characterized by the speed-up of the life cycle of skin cells, leading to cells building up rapidly on the surface of the skin.
Symptoms of psoriasis are caused by the extra skin cells forming scales and red patches can be itchy and painful.
Epidemiologically, psoriasis patches can range from a few spots or large areas. The most common form of psoriasis is plaque psoriasis, a condition that induces dry, raised, red skin lesions (plaques) covered with silvery scales.
The causes of psoriasis are not identified. Researchers do not know why people with
the same health conditions in the same family, some are prone to psoriasis while others do not.
Certain risk factors such as family history, viral and bacterial infections, weakened immune systems, persistent stress, smoking, and obesity are associated with the risk of psoriasis.
Conventionally, topical corticosteroids are the most commonly prescribed medication for the treatment of the condition, particularly in patients with mild to moderate psoriasis.
If you are using corticosteroids for the treatment of psoriasis, please make sure you know all the side effects for preventive measures.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential ingredient for the treatment of psoriasis, an autoimmune and recurrent chronic inflammatory skin disorder, researchers examined a turmeric tonic as immune modulation and anti-inflammatory therapy on scalp psoriasis.
The study included a total of 40 patients with mild-to-moderate scalp psoriasis who fulfilled the inclusion criteria and were randomly allocated into two groups.
The treatment group received turmeric tonic twice a day for 9 weeks, whereas the other group received a placebo applied in the same manner.
Based on the results from the assessment of baseline, weeks 3, 6, and 9, the treatment group not only significantly reduced the erythema, scaling, and the duration of lesions (PASI score), but also improved the patient's quality of life. compared to a placebo.
Researchers after taking other factors into account wrote, "The clinical effects of turmeric tonic on scalp psoriasis were satisfactory overall. This formulation could be considered as a treatment for scalp psoriasis".
In order to reveal more information about turmeric anti-psoriasis activity, researchers reviewed the effect of turmeric in the inhibition of inflammatory enzymes mainly involved in the inflammatory process of psoriasis.
The study included the examination of the randomized, clinical, and therapeutic benefit of a novel topical formulation, including turmeric on 34 patients with mild to moderate plaque psoriasis.
The treatment group showed a significant improvement in the symptoms of psoriasis and
the clinical and quality of life parameters compared to the untreated group.
Based on the findings, Dr. the lead scientist said, "The proposed microemulgel may well be considered as an alternative in some patients and most likely as an add-on therapeutic option for many patients suffering from plaque psoriasis".
Taken altogether, turmeric processed bioactive ingredient curcumin may be considered asupplement for the treatment of psoriasis,, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial by Bahraini P1, Rajabi M1, Mansouri P2, Sarafian G1, Chalangari R3, Azizian Z. (PubMed)
(2) Topical Turmeric Microemulgel in the Management of Plaque Psoriasis; A Clinical Evaluation by Sarafian G1, Afshar M2, Mansouri P3, Asgarpanah J4, Raoufinejad K1, Rajabi M. (PubMed)
Psoriasis is a skin condition characterized by the speed-up of the life cycle of skin cells, leading to cells building up rapidly on the surface of the skin.
Symptoms of psoriasis are caused by the extra skin cells forming scales and red patches can be itchy and painful.
Epidemiologically, psoriasis patches can range from a few spots or large areas. The most common form of psoriasis is plaque psoriasis, a condition that induces dry, raised, red skin lesions (plaques) covered with silvery scales.
The causes of psoriasis are not identified. Researchers do not know why people with
the same health conditions in the same family, some are prone to psoriasis while others do not.
Certain risk factors such as family history, viral and bacterial infections, weakened immune systems, persistent stress, smoking, and obesity are associated with the risk of psoriasis.
Conventionally, topical corticosteroids are the most commonly prescribed medication for the treatment of the condition, particularly in patients with mild to moderate psoriasis.
If you are using corticosteroids for the treatment of psoriasis, please make sure you know all the side effects for preventive measures.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential ingredient for the treatment of psoriasis, an autoimmune and recurrent chronic inflammatory skin disorder, researchers examined a turmeric tonic as immune modulation and anti-inflammatory therapy on scalp psoriasis.
The study included a total of 40 patients with mild-to-moderate scalp psoriasis who fulfilled the inclusion criteria and were randomly allocated into two groups.
The treatment group received turmeric tonic twice a day for 9 weeks, whereas the other group received a placebo applied in the same manner.
Based on the results from the assessment of baseline, weeks 3, 6, and 9, the treatment group not only significantly reduced the erythema, scaling, and the duration of lesions (PASI score), but also improved the patient's quality of life. compared to a placebo.
Researchers after taking other factors into account wrote, "The clinical effects of turmeric tonic on scalp psoriasis were satisfactory overall. This formulation could be considered as a treatment for scalp psoriasis".
In order to reveal more information about turmeric anti-psoriasis activity, researchers reviewed the effect of turmeric in the inhibition of inflammatory enzymes mainly involved in the inflammatory process of psoriasis.
The study included the examination of the randomized, clinical, and therapeutic benefit of a novel topical formulation, including turmeric on 34 patients with mild to moderate plaque psoriasis.
The treatment group showed a significant improvement in the symptoms of psoriasis and
the clinical and quality of life parameters compared to the untreated group.
Based on the findings, Dr. the lead scientist said, "The proposed microemulgel may well be considered as an alternative in some patients and most likely as an add-on therapeutic option for many patients suffering from plaque psoriasis".
Taken altogether, turmeric processed bioactive ingredient curcumin may be considered asupplement for the treatment of psoriasis,, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial by Bahraini P1, Rajabi M1, Mansouri P2, Sarafian G1, Chalangari R3, Azizian Z. (PubMed)
(2) Topical Turmeric Microemulgel in the Management of Plaque Psoriasis; A Clinical Evaluation by Sarafian G1, Afshar M2, Mansouri P3, Asgarpanah J4, Raoufinejad K1, Rajabi M. (PubMed)
#Manuka and Clover Honey Exerts a Strong Exert Anti Varicella Zoster Virus (VZV) Activity, Researchers Suggest
Kyle J. Norton
Honey may have a profound effect in reducing the risk and treatment of varicella-zoster virus (VZV), some scientists suggested.
Varicella-zoster virus is a member of the herpes viruses that cause chickenpox in children, teens, and young adults, and shingles and recurrent shingles in adults.
The disease has been found worldwide and is highly contagious.
Chickenpox is usually caused by exposure either through direct contact with a skin lesion or airborne spread from respiratory droplets from infected patients.
In the initial stage of infection, the symptoms usually resolve within 7 to 10 days.
After initial infection, VZV establishes lifelong latency in the cranial nerve and dorsal root ganglia and can reactivate years to decades later.
Reactivation of the dormant virus results in the later years can lead to a painful dermatomal rash followed by pain in the distribution of the rash.
In some cases, the diseases can cause infrequently complications of hepatitis, pancreatitis, pneumonitis, and encephalitis and be life-threatening.
However, some adults and children are more likely to develop such complications from primary infection
According to the statistics, in the US, more than 90% of adults acquired the disease in childhood, due to being vaccinated with the live virus vaccine.
Dr. Maria A. Nagel and colleagues in the summary of the disease associated with the Varicella zoster virus (VZV), said, "With advancing age or immunosuppression, cell-mediated immunity to VZV declines and virus reactivates to cause zoster (shingles), which can occur anywhere on the body"
" Skin lesions resolve within 1-2 weeks, while complete cessation of pain usually takes 4-6 weeks" and "Zoster can be followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresis, meningoencephalitis, cerebellitis, myelopathy, multiple ocular disorders and vasculopathy that can mimic giant cell arteritis. All of the neurological and ocular disorders listed above may also develop without rash".
These results clearly suggested that the elderly due to the increase in age and weakened immune system, are considered to be the risk group for the development of serious and even life-threatening complications.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
With an aim to find a natural ingredient ]or whole food for the prevention and treatment of varicella-zoster virus (VZV) infection, researchers at the University of Colorado Denver evaluated the anti-viral effect of honey on the varicella-zoster virus in vitro.
The tested VZV was obtained from a zoster vesicle.
Manuka and clover kinds of honey were used at concentrations ranging from 0-6% wt/vol in the study.
During the experiment, various concentrations of manuka and clover honey were added to the tissue culture medium of the VZV-infected human malignant melanoma (MeWo) cell.
According to the assay, both types of honey demonstrated significant antiviral activity against the varicella-zoster virus with an approximate EC50 = 4.5 % (wt/vol).
In the final report, researchers suggested honey can be considered an anti-varicella-zoster virus agent because it is an inexpensive product that can be bought at any grocery store and convenient for skin application.
Dr. Shahzad A, said, "Honey may be an excellent remedy to treat zoster rash in developing countries where antiviral drugs are expensive or not easily available".
Taken altogether, honey may be used as a topical function food for the prevention of varicella-zoster virus (VZV) infection and combined with primary therapy for the treatment of chickenpox in children and shingles and recurrent shingles in adults with no side effects.
However, further data collection large example size, and multi-center studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of honey anti chickenpox and anti shingles possibilities.
.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles by Shahzad A1, Cohrs RJ. (PubMed)
(2) Varicella Zoster Complications by Maria A. Nagel, MDa, and Don Gilden, MD. (PubMed)
Honey may have a profound effect in reducing the risk and treatment of varicella-zoster virus (VZV), some scientists suggested.
Varicella-zoster virus is a member of the herpes viruses that cause chickenpox in children, teens, and young adults, and shingles and recurrent shingles in adults.
The disease has been found worldwide and is highly contagious.
Chickenpox is usually caused by exposure either through direct contact with a skin lesion or airborne spread from respiratory droplets from infected patients.
In the initial stage of infection, the symptoms usually resolve within 7 to 10 days.
After initial infection, VZV establishes lifelong latency in the cranial nerve and dorsal root ganglia and can reactivate years to decades later.
Reactivation of the dormant virus results in the later years can lead to a painful dermatomal rash followed by pain in the distribution of the rash.
In some cases, the diseases can cause infrequently complications of hepatitis, pancreatitis, pneumonitis, and encephalitis and be life-threatening.
However, some adults and children are more likely to develop such complications from primary infection
According to the statistics, in the US, more than 90% of adults acquired the disease in childhood, due to being vaccinated with the live virus vaccine.
Dr. Maria A. Nagel and colleagues in the summary of the disease associated with the Varicella zoster virus (VZV), said, "With advancing age or immunosuppression, cell-mediated immunity to VZV declines and virus reactivates to cause zoster (shingles), which can occur anywhere on the body"
" Skin lesions resolve within 1-2 weeks, while complete cessation of pain usually takes 4-6 weeks" and "Zoster can be followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresis, meningoencephalitis, cerebellitis, myelopathy, multiple ocular disorders and vasculopathy that can mimic giant cell arteritis. All of the neurological and ocular disorders listed above may also develop without rash".
These results clearly suggested that the elderly due to the increase in age and weakened immune system, are considered to be the risk group for the development of serious and even life-threatening complications.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
With an aim to find a natural ingredient ]or whole food for the prevention and treatment of varicella-zoster virus (VZV) infection, researchers at the University of Colorado Denver evaluated the anti-viral effect of honey on the varicella-zoster virus in vitro.
The tested VZV was obtained from a zoster vesicle.
Manuka and clover kinds of honey were used at concentrations ranging from 0-6% wt/vol in the study.
During the experiment, various concentrations of manuka and clover honey were added to the tissue culture medium of the VZV-infected human malignant melanoma (MeWo) cell.
According to the assay, both types of honey demonstrated significant antiviral activity against the varicella-zoster virus with an approximate EC50 = 4.5 % (wt/vol).
In the final report, researchers suggested honey can be considered an anti-varicella-zoster virus agent because it is an inexpensive product that can be bought at any grocery store and convenient for skin application.
Dr. Shahzad A, said, "Honey may be an excellent remedy to treat zoster rash in developing countries where antiviral drugs are expensive or not easily available".
Taken altogether, honey may be used as a topical function food for the prevention of varicella-zoster virus (VZV) infection and combined with primary therapy for the treatment of chickenpox in children and shingles and recurrent shingles in adults with no side effects.
However, further data collection large example size, and multi-center studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of honey anti chickenpox and anti shingles possibilities.
.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles by Shahzad A1, Cohrs RJ. (PubMed)
(2) Varicella Zoster Complications by Maria A. Nagel, MDa, and Don Gilden, MD. (PubMed)
#Intake of RAW Fruits and Vegetables Regularly are Associated with a Reduced Risk of #PancreaticCancer, Researchers Suggest
Kyle J. Norton
The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas aids the digestive system in breaking down carbohydrates, proteins, and lipids.
Traditional Chinese medicine suggests that the pancreas is a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.
Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue, and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.
The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer. The 5-year survival rate for stage IA pancreatic cancer is only14%.
Researchers do not know what causes pancreatic cancer. Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).
Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age, and ethnicity are associated with the early onset of pancreatic cancer.
Researchers at the Johns Hopkins Medical Center suggested an unhealthy diet high in meats, cholesterol, fried foods, and nitrosamines may increase risk, while diets high in fruits and vegetables reduce the risk of pancreatic cancer.
However, most people with some of the above risk factors do not get the disease.
In finding a potent ingredient for the treatment of diseases associated with abnormal cell growth, researchers investigated the consumption of raw fruits and vegetables' effects on pancreatic cancer.
According to the dietary habits and medical history variables in a prospective study of fatal pancreas cancer among 34,000 California Seventh-day Adventists between 1976 and 1983. Forty deaths from pancreas cancer occurred during the follow-up period,
* Compared to all US whites, Adventists experienced a decreased risk of pancreas cancer death (standardized mortality ratio [SMR] = 72 for men; 90 for women),
* Furthermore, increasing consumption of vegetarian protein products, beans, lentils, and peas, as well as dried fruit, was associated with highly significant protective relationships to pancreas cancer risk compared to increased risk in increasing meat, egg, and coffee consumption.
In other words, regular consumption of raw fruits and vegetables exerted protective relationships associated with a protease-inhibitor content that decreases the risk of pancreas cancer in high-risk patients.
Taken together, fruits and vegetables may be considered a functional food for the prevention of pancreas cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists by Mills PK1, Beeson WL, Abbey DE, Fraser GE, Phillips RL.(PubMed)
The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas aids the digestive system in breaking down carbohydrates, proteins, and lipids.
Traditional Chinese medicine suggests that the pancreas is a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.
Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue, and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.
The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer. The 5-year survival rate for stage IA pancreatic cancer is only14%.
Researchers do not know what causes pancreatic cancer. Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).
Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age, and ethnicity are associated with the early onset of pancreatic cancer.
Researchers at the Johns Hopkins Medical Center suggested an unhealthy diet high in meats, cholesterol, fried foods, and nitrosamines may increase risk, while diets high in fruits and vegetables reduce the risk of pancreatic cancer.
However, most people with some of the above risk factors do not get the disease.
In finding a potent ingredient for the treatment of diseases associated with abnormal cell growth, researchers investigated the consumption of raw fruits and vegetables' effects on pancreatic cancer.
According to the dietary habits and medical history variables in a prospective study of fatal pancreas cancer among 34,000 California Seventh-day Adventists between 1976 and 1983. Forty deaths from pancreas cancer occurred during the follow-up period,
* Compared to all US whites, Adventists experienced a decreased risk of pancreas cancer death (standardized mortality ratio [SMR] = 72 for men; 90 for women),
* Furthermore, increasing consumption of vegetarian protein products, beans, lentils, and peas, as well as dried fruit, was associated with highly significant protective relationships to pancreas cancer risk compared to increased risk in increasing meat, egg, and coffee consumption.
In other words, regular consumption of raw fruits and vegetables exerted protective relationships associated with a protease-inhibitor content that decreases the risk of pancreas cancer in high-risk patients.
Taken together, fruits and vegetables may be considered a functional food for the prevention of pancreas cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists by Mills PK1, Beeson WL, Abbey DE, Fraser GE, Phillips RL.(PubMed)
#Ethanolic #Extract Found in #CynometraCauliflora Leaves Inhibits Parameters Associated with the Onset of Obesity, Scientists Say
Kyle J. Norton
Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.
In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.
Similar to other chronic medical conditions including diabetes, cardiovascular disease or high blood pressure, obesity has recently become a serious health problem in the US as nearly 35% of Americans are obese accompanied by a similar percentage of overweight adults.
Obesity and overweight in the U.S. economy have eclipsed $1.7 trillion, equivalent to 9.3 percent of the nation's gross domestic product, according to a new overweight report on chronic diseases.
Dr. Maximilian Tremmel, the lead scientist in a systematic literature review of the economic burden of obesity, wrote, " almost half of the world’s adult population will be overweight or obese by 2030 if the prevalence continues on the current trend [6] and consequently also the costs attributable to obesity will increase".
And, "A useful example for rapidly rising costs attributable to obesity from these selected studies are the two mentioned studies from Germany [44,46]. The results of the two papers together show that total societal costs in Germany due to obesity have increased from €9.8 million to €12.2 million between 2002 and 2008. Therefore, public health interventions should focus on the prevention of obesity as soon as possible, ideally at a young age".
Cynometra cauliflora is a species of the genus Cynometra, native to Malaysia, and found mainly in northern Peninsular Malaysia.
In finding a potential phytochemical for the prevention and treatment of chronic diseases, researchers examined the anti-obesity and lipid-lowering effects of ethanolic extract of C. cauliflora leaves and its major compound (vitexin) in C57BL/6 obese mice induced by a high-fat diet (HFD).
The study included male C57BL/6 mice induced obesity by feeding with HFD (60% fat) for 16 weeks followed by the treatment that starts during the last 8 weeks of HFD feeding with C. cauliflora leaf extract at 200 and 400 mg/kg/day, orlistat (10 mg/kg) and vitexin (10 mg/kg).
According to the chemical analysis,
* The oral administration of C. cauliflora (400 and 200 mg/kg) and vitexin significantly reduced body weight, adipose tissue and liver weight, and lipid accumulation in the liver compared to the control HFD group.
* Both doses of C. cauliflora also significantly (P ≤ 0.05) decreased serum triglyceride, LDL, lipase, IL-6, peptide YY, resistin levels, hyperglycemia, hyperinsulinemia, and hyperleptinemia compared to the control HFD group.
* C. cauliflora significantly up-regulated the expression of adiponectin, Glut4, Mtor, IRS-1 and InsR genes associated with the sustaining weight loss and significantly decreased the expression of Lepr in white adipose tissue involved in stimulating weight gain.
Based on the findings, researchers said, "This study shows interesting outcomes of C. cauliflora against HFD-induced obesity and associated metabolic abnormalities".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of bacterial infectious diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice by Seyedan A1, Mohamed Z2, Alshagga MA3, Koosha S4, Alshawsh MA. (PubMed)
(2) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)
Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.
In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.
Similar to other chronic medical conditions including diabetes, cardiovascular disease or high blood pressure, obesity has recently become a serious health problem in the US as nearly 35% of Americans are obese accompanied by a similar percentage of overweight adults.
Obesity and overweight in the U.S. economy have eclipsed $1.7 trillion, equivalent to 9.3 percent of the nation's gross domestic product, according to a new overweight report on chronic diseases.
Dr. Maximilian Tremmel, the lead scientist in a systematic literature review of the economic burden of obesity, wrote, " almost half of the world’s adult population will be overweight or obese by 2030 if the prevalence continues on the current trend [6] and consequently also the costs attributable to obesity will increase".
And, "A useful example for rapidly rising costs attributable to obesity from these selected studies are the two mentioned studies from Germany [44,46]. The results of the two papers together show that total societal costs in Germany due to obesity have increased from €9.8 million to €12.2 million between 2002 and 2008. Therefore, public health interventions should focus on the prevention of obesity as soon as possible, ideally at a young age".
Cynometra cauliflora is a species of the genus Cynometra, native to Malaysia, and found mainly in northern Peninsular Malaysia.
In finding a potential phytochemical for the prevention and treatment of chronic diseases, researchers examined the anti-obesity and lipid-lowering effects of ethanolic extract of C. cauliflora leaves and its major compound (vitexin) in C57BL/6 obese mice induced by a high-fat diet (HFD).
The study included male C57BL/6 mice induced obesity by feeding with HFD (60% fat) for 16 weeks followed by the treatment that starts during the last 8 weeks of HFD feeding with C. cauliflora leaf extract at 200 and 400 mg/kg/day, orlistat (10 mg/kg) and vitexin (10 mg/kg).
According to the chemical analysis,
* The oral administration of C. cauliflora (400 and 200 mg/kg) and vitexin significantly reduced body weight, adipose tissue and liver weight, and lipid accumulation in the liver compared to the control HFD group.
* Both doses of C. cauliflora also significantly (P ≤ 0.05) decreased serum triglyceride, LDL, lipase, IL-6, peptide YY, resistin levels, hyperglycemia, hyperinsulinemia, and hyperleptinemia compared to the control HFD group.
* C. cauliflora significantly up-regulated the expression of adiponectin, Glut4, Mtor, IRS-1 and InsR genes associated with the sustaining weight loss and significantly decreased the expression of Lepr in white adipose tissue involved in stimulating weight gain.
Based on the findings, researchers said, "This study shows interesting outcomes of C. cauliflora against HFD-induced obesity and associated metabolic abnormalities".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of bacterial infectious diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice by Seyedan A1, Mohamed Z2, Alshagga MA3, Koosha S4, Alshawsh MA. (PubMed)
(2) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)
#Betacyanins Process a Strong #Antioxidant Capacity According to Studies
Kyle J. Norton
Oxidative stress is a medical condition caused by the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.
In fact, free radicals exist everywhere including the airs we breathe, the thing we eat and the environment we contact, particularly, cell metabolism in the body.
Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.
Other diseases such as hypertension, dyslipidemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity are also found in patients with oxidative stress.
In spite of free radicals' harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.
Free radicals are unstable atoms with an unpair of electrons on the outer ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules that inhibit free radicals.
Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.
Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, for people with weakened immune systems intake of dietary antioxidants or antioxidant supplements may be necessary.
Dr. Pignatelli P. the lead scientist in the investigation of the relationship between oxidative stress and antioxidants in CVD wrote, " 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress".
In other words, by understanding the interaction of free radicals and antioxidant, diseases associated with oxidative stress may be preventable.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllocactin, and betanidin.
According to the test from the peroxyl radical generating system, betacyanins exerted a significant peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).
In chemical analysis, betanidin, betanin, and phyllocactin demonstrated antioxidant capacity at the order of 10.70, 3.31, and 2.83 mol-TEA/mol-compound respectively.
The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin, and betanidin.was 24.48, 17.51, and 6.81, respectively.
In other words, betanidin was the strongest antioxdant that exerted radical scavenging activity compared to those of betanin, and phyllocactin.
Furthermore, the expression of free radical NO was reduced by the administration of betacyanin in the low concentration range of 2.5-20 μM.
Based on the results, researchers said, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".
And, "This study demonstrated that the betacyanins will be useful as natural pigments to provide defense against oxidative stress".
Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Oxidative stress and cardiovascular disease: new insights by Pignatelli P1, Menichelli D, Pastori D, Violi F. (PubMed)
Oxidative stress is a medical condition caused by the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.
In fact, free radicals exist everywhere including the airs we breathe, the thing we eat and the environment we contact, particularly, cell metabolism in the body.
Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.
Other diseases such as hypertension, dyslipidemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity are also found in patients with oxidative stress.
In spite of free radicals' harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.
Free radicals are unstable atoms with an unpair of electrons on the outer ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules that inhibit free radicals.
Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.
Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, for people with weakened immune systems intake of dietary antioxidants or antioxidant supplements may be necessary.
Dr. Pignatelli P. the lead scientist in the investigation of the relationship between oxidative stress and antioxidants in CVD wrote, " 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress".
In other words, by understanding the interaction of free radicals and antioxidant, diseases associated with oxidative stress may be preventable.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllocactin, and betanidin.
According to the test from the peroxyl radical generating system, betacyanins exerted a significant peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).
In chemical analysis, betanidin, betanin, and phyllocactin demonstrated antioxidant capacity at the order of 10.70, 3.31, and 2.83 mol-TEA/mol-compound respectively.
The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin, and betanidin.was 24.48, 17.51, and 6.81, respectively.
In other words, betanidin was the strongest antioxdant that exerted radical scavenging activity compared to those of betanin, and phyllocactin.
Furthermore, the expression of free radical NO was reduced by the administration of betacyanin in the low concentration range of 2.5-20 μM.
Based on the results, researchers said, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".
And, "This study demonstrated that the betacyanins will be useful as natural pigments to provide defense against oxidative stress".
Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Oxidative stress and cardiovascular disease: new insights by Pignatelli P1, Menichelli D, Pastori D, Violi F. (PubMed)
#Cranberry, a Promising Gingipain and Periodontitis inhibitor, Researchers Find
Kyle J. Norton
Periodontitis is a serious case of gingivitis associated with gum infection that damages the soft tissue and destroys the bone that supports your teeth as a result of long-term poor oral hygiene
Periodontitis is preventable if the progression of gingivitis stages is stopped
Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.
Gingivitis dental plaques formed around the base of the teeth are sticky biofilms of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.
At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.
Epidemiologically, risk factors that induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medications including oral contraceptives, steroids, anticonvulsants, and calcium channel blockers.
Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.
The Colgate Professional the examined the symptoms and advised that if you have experienced some of the symptoms that do not heal themselves in a short time, such as puffy or swollen, or tender, bleeding during brushing or flossing,... and constant bad breath or a bad taste in your mouth, you may have gingivitis.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of periodontitis, researchers examined the effect of cranberry and rice extracts as a potent gingipain inhibitor.
Based on the tested analysis, cranberry and rice extracts interfere with gingipain activity that causes the slowing down the progression of adult periodontitis.
Furthermore, the extracts prevented the growth and biofilm formation of periodontal pathogens and induced the onset of periodontitis.
Moreover, the extracts also inhibited a broad spectrum of host proteases in the induction of undesirable side effects
As of today, the ideal gingipain inhibitor has yet to be discovered, however, cranberry and rice extracts may be a promising gingipain inhibitor compared to gingipain N-terminal pro domains, synthetic compounds, antibiotics, antiseptics, antibodies, and bacteria which may induce undesirable side effects
The results strongly suggested that cranberry promotes oral health by inhibiting the onset and progression of periodontitis through its anti-bacterial activity
Taken together, cranberry may be considered a remedy for the prevention and treatment of periodontitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)
Periodontitis is a serious case of gingivitis associated with gum infection that damages the soft tissue and destroys the bone that supports your teeth as a result of long-term poor oral hygiene
Periodontitis is preventable if the progression of gingivitis stages is stopped
Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.
Gingivitis dental plaques formed around the base of the teeth are sticky biofilms of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.
At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.
Epidemiologically, risk factors that induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medications including oral contraceptives, steroids, anticonvulsants, and calcium channel blockers.
Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.
The Colgate Professional the examined the symptoms and advised that if you have experienced some of the symptoms that do not heal themselves in a short time, such as puffy or swollen, or tender, bleeding during brushing or flossing,... and constant bad breath or a bad taste in your mouth, you may have gingivitis.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of periodontitis, researchers examined the effect of cranberry and rice extracts as a potent gingipain inhibitor.
Based on the tested analysis, cranberry and rice extracts interfere with gingipain activity that causes the slowing down the progression of adult periodontitis.
Furthermore, the extracts prevented the growth and biofilm formation of periodontal pathogens and induced the onset of periodontitis.
Moreover, the extracts also inhibited a broad spectrum of host proteases in the induction of undesirable side effects
As of today, the ideal gingipain inhibitor has yet to be discovered, however, cranberry and rice extracts may be a promising gingipain inhibitor compared to gingipain N-terminal pro domains, synthetic compounds, antibiotics, antiseptics, antibodies, and bacteria which may induce undesirable side effects
The results strongly suggested that cranberry promotes oral health by inhibiting the onset and progression of periodontitis through its anti-bacterial activity
Taken together, cranberry may be considered a remedy for the prevention and treatment of periodontitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)
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