Kyle J. Norton
An increase in the biosynthesis of fatty acids is associated with the onset of Non-alcoholic fatty liver (NAFL).
A fatty liver is a liver condition associated with the accumulation of excess fat in the liver.
Non-alcoholic fatty liver (NAFL) is the early stage of nonalcoholic steatohepatitis (NASH) caused by the accumulation of fat in the liver, other than excessive use of alcohol.
Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.
Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars and reduces the performance of the liver.
In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.
Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.
As of today, there is no effective treatment of NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms delay the progression of the condition and improve the quality of life.
Collard Green is a species of Brassica Oleracea, belonging to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
In findings a potential compound for the modulation of liver fatty acid, researchers examined the effects of diets containing 4% collard greens, purslane, or sweet potato greens on the liver fatty acid profiles of four-week-old male spontaneously hypertensive rats (SHRs) for 4 weeks.
Based on the tested assays, SHRs received in the control diet had greater percentages of liver saturated fatty acid and less omega-3 fatty acid percentages.
Moreover, the SHRs that consumed the control diet also had significantly greater percentages of oleic; and significantly less γ-linolenic and docosahexaenoic acids.
However, SHRs that received the diets containing vegetables had significantly greater liver concentrations of γ- linolenic, docosahexaenoic, and docosahexaenoic acids, as well as lower levels of lauric, palmitic, and arachidonic acids.
In other words, 4% collard greens, purslane or sweet potato greens showed a strong effect in reducing the risk of fatty liver in hypertensive rats (SHRs) after 4 weeks of consumption by improving the liver profile parameters.
Taken together, collard green may be considered a supplement for the prevention and treatment of liver disease associated with the expression of liver fatty acid, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diets containing traditional and novel green leafy vegetables improve liver fatty acid profiles of spontaneously hypertensive rats by Johnson M, Pace RD, Dawkins NL, Willian KR. (PubMed)
Saturday, 9 September 2023
#TomatoJuices Suppress the Onset of Pulmonary Fibrosis and Attenuate Hyperoxia Induced Overexpression of ROS, Researchers Say
Kyle J. Norton
Pulmonary diseases are a class of diseases associated with the lungs, including asthma, COPD, influenza, pneumonia tuberculosis, and lung cancer.
In other words, any diseases involved in breathing problems that reduce the function of the lungs are pulmonary diseases.
The most common pulmonary diseases are
* Asthma
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
* Pneumothorax
Pneumothorax is a condition of collection of air within the pleural cavity, from either the outside or from the lung.
* Bronchitis
Bronchitis is a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma.
* COPD (chronic obstructive pulmonary disease)** Emphysema is a type of COPD with a long-term and progressive condition that causes shortness of breath, depending on the stage of lung function associated with the damage of tissues of the air sacs (alveoli) in the lungs.
** Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung associated with difficulty of breathing.
*Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells
* PneumoniaPneumonia is a condition of the inflammation of the lung caused by bacteria, such as bacterial infection, Streptococcus pneumonia, or influenza viruses in most cases.
* Pulmonary edema
Pulmonary edema is a condition of fluid accumulation in the air spaces and parenchyma of the lungs that leads to difficulty breathing and respiratory failure.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential ingredient for the treatment of pulmonary disease, researchers examined the dietary supplementation of tomato juice, TJ protection against the developing lung injury caused by breathing hyperoxic gas.
Neonatal mice (C57BL6/J) breathed either 65% O2 (hyperoxia) or room air from birth until postnatal day 7 (P7d)selected for the study underwent necropsy at P7d or raised in room air until adulthood (P56d). In a subset of both groups, drinking water was replaced with TJ (diluted 50:50 in water) from late gestation to necropsy.
In P7d, TJ injection increased pulmonary total antioxidants (TAC) and COL1α1 expression associated with pulmonary fibrosis and attenuated the hyperoxia-induced increase in production ROS without affecting the changes in lung structure.
Furthermore, in P56d, TJ increased TAC, decreased oxidative stress, and reversed the hyperoxia-induced increase in bronchiolar smooth muscle by ameliorating the production of pro-inflammatory cytokines.
Based on the findings, researchers said, "TJ supplementation during and after neonatal exposure to hyperoxia protects the lung from some but not all aspects of hyperoxia-induced injury".
In other words, TJ protects the lung against injury by stimulating the expression of circulation of antioxidant concentration.
Taken together, tomatoes may be considered supplements for the prevention and treatment of pulmonary diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus) by Bouch S1, Harding R1, O'Reilly M1, Wood LG2, Sozo F. (PubMed)
(2) Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression by Yan KH1, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS. (PubMed)
Pulmonary diseases are a class of diseases associated with the lungs, including asthma, COPD, influenza, pneumonia tuberculosis, and lung cancer.
In other words, any diseases involved in breathing problems that reduce the function of the lungs are pulmonary diseases.
The most common pulmonary diseases are
* Asthma
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
* Pneumothorax
Pneumothorax is a condition of collection of air within the pleural cavity, from either the outside or from the lung.
* Bronchitis
Bronchitis is a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma.
* COPD (chronic obstructive pulmonary disease)** Emphysema is a type of COPD with a long-term and progressive condition that causes shortness of breath, depending on the stage of lung function associated with the damage of tissues of the air sacs (alveoli) in the lungs.
** Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung associated with difficulty of breathing.
*Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells
* PneumoniaPneumonia is a condition of the inflammation of the lung caused by bacteria, such as bacterial infection, Streptococcus pneumonia, or influenza viruses in most cases.
* Pulmonary edema
Pulmonary edema is a condition of fluid accumulation in the air spaces and parenchyma of the lungs that leads to difficulty breathing and respiratory failure.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential ingredient for the treatment of pulmonary disease, researchers examined the dietary supplementation of tomato juice, TJ protection against the developing lung injury caused by breathing hyperoxic gas.
Neonatal mice (C57BL6/J) breathed either 65% O2 (hyperoxia) or room air from birth until postnatal day 7 (P7d)selected for the study underwent necropsy at P7d or raised in room air until adulthood (P56d). In a subset of both groups, drinking water was replaced with TJ (diluted 50:50 in water) from late gestation to necropsy.
In P7d, TJ injection increased pulmonary total antioxidants (TAC) and COL1α1 expression associated with pulmonary fibrosis and attenuated the hyperoxia-induced increase in production ROS without affecting the changes in lung structure.
Furthermore, in P56d, TJ increased TAC, decreased oxidative stress, and reversed the hyperoxia-induced increase in bronchiolar smooth muscle by ameliorating the production of pro-inflammatory cytokines.
Based on the findings, researchers said, "TJ supplementation during and after neonatal exposure to hyperoxia protects the lung from some but not all aspects of hyperoxia-induced injury".
In other words, TJ protects the lung against injury by stimulating the expression of circulation of antioxidant concentration.
Taken together, tomatoes may be considered supplements for the prevention and treatment of pulmonary diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus) by Bouch S1, Harding R1, O'Reilly M1, Wood LG2, Sozo F. (PubMed)
(2) Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression by Yan KH1, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS. (PubMed)
#Hibiscus #Sabdariffa Exerts a Strong Anti Bacterial Infection Activity, Scientists Show
Kyle J. Norton
Infectious diseases are medical conditions caused by pathogenic microorganisms, including bacteria, viruses, parasites, or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistics provided by the World Health Organization, infectious diseases were ranked in the top ten causes of death worldwide in 2016.
A bacterial infection is an infected caused bacteria.
Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulate the production of blood palette to cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.
However, the overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damaged the nearby healthy cells, leading to the formation of scars.
In most cases in a healthy individual, depending on the size of the wound, the immune system can easily eradicate all foreign invaders, and the wound is recovered within days and weeks.
Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, diarrhea, short-term joint or muscle pain, fever, headache, skin rash, and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.
The most common types of bacterial infections are bacterial meningitis, otitis media, pneumonia, and tuberculosis.
Roselle (Hibiscus sabdariffa) is a species of Hibiscus probably native to West Africa used in traditional Chinese medicine to resolve phlegm and food stagnation and regulate the Liver to aid digestion, promote weight loss, reduce cholesterol, improve circulation, and lower blood pressure.
With an aim to find natural food for the treatment of infectious diseases,, researchers compared the effects of rude, phenolic-rich extracts (CPREs) isolated from different sources, such as Hibiscus sabdariffa (H. sabdariffa, Roselle), Brassica oleracea var. capitata f. Rubra (B. oleracea, red cabbage) and Beta vulgaris (B. Vulgaris).
According to the tested differentiation, the administration of CPREs showed potential antibacterial and antifungal activities.
According to chemical analysis, total anthocyanins content (TAC), total phenolic content (TPC), total flavonoid content (TFC), and other compounds found in all three CPREs demonstrated strong antimicrobial effects against pathogenic bacteria and fungi.
Hibiscus sabdariffa CPRE (HCPRE) at a dose of 50 μg/mL exhibited signs of asymmetric, wrinkled exterior surfaces, cell deformations, and loss of cell shapes against Staphylococcus aureus DSM 1104 and Klebsiella pneumonia ATCC 43816.
The injection of CPRE also led to cell clumping, malformations, blisters, cell depressions, and diminished cell numbers.
In other words, CPRE induced the death of bacterial cells and loss of cell contents.
Taken altogether, Hibiscus sabdariffa may be considered a remedy for the prevention and treatment of infectious diseases, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antimicrobial Activity and Chemical Constitution of the Crude, Phenolic-Rich Extracts of Hibiscus sabdariffa, Brassica oleracea, and Beta vulgaris by Abdel-Shafi S1, Al-Mohammadi AR2, Sitohy M3, Mosa B1, Ismaiel A1, Enan G1, Osman A. (PubMed)
Infectious diseases are medical conditions caused by pathogenic microorganisms, including bacteria, viruses, parasites, or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistics provided by the World Health Organization, infectious diseases were ranked in the top ten causes of death worldwide in 2016.
A bacterial infection is an infected caused bacteria.
Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulate the production of blood palette to cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.
However, the overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damaged the nearby healthy cells, leading to the formation of scars.
In most cases in a healthy individual, depending on the size of the wound, the immune system can easily eradicate all foreign invaders, and the wound is recovered within days and weeks.
Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, diarrhea, short-term joint or muscle pain, fever, headache, skin rash, and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.
The most common types of bacterial infections are bacterial meningitis, otitis media, pneumonia, and tuberculosis.
Roselle (Hibiscus sabdariffa) is a species of Hibiscus probably native to West Africa used in traditional Chinese medicine to resolve phlegm and food stagnation and regulate the Liver to aid digestion, promote weight loss, reduce cholesterol, improve circulation, and lower blood pressure.
With an aim to find natural food for the treatment of infectious diseases,, researchers compared the effects of rude, phenolic-rich extracts (CPREs) isolated from different sources, such as Hibiscus sabdariffa (H. sabdariffa, Roselle), Brassica oleracea var. capitata f. Rubra (B. oleracea, red cabbage) and Beta vulgaris (B. Vulgaris).
According to the tested differentiation, the administration of CPREs showed potential antibacterial and antifungal activities.
According to chemical analysis, total anthocyanins content (TAC), total phenolic content (TPC), total flavonoid content (TFC), and other compounds found in all three CPREs demonstrated strong antimicrobial effects against pathogenic bacteria and fungi.
Hibiscus sabdariffa CPRE (HCPRE) at a dose of 50 μg/mL exhibited signs of asymmetric, wrinkled exterior surfaces, cell deformations, and loss of cell shapes against Staphylococcus aureus DSM 1104 and Klebsiella pneumonia ATCC 43816.
The injection of CPRE also led to cell clumping, malformations, blisters, cell depressions, and diminished cell numbers.
In other words, CPRE induced the death of bacterial cells and loss of cell contents.
Taken altogether, Hibiscus sabdariffa may be considered a remedy for the prevention and treatment of infectious diseases, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antimicrobial Activity and Chemical Constitution of the Crude, Phenolic-Rich Extracts of Hibiscus sabdariffa, Brassica oleracea, and Beta vulgaris by Abdel-Shafi S1, Al-Mohammadi AR2, Sitohy M3, Mosa B1, Ismaiel A1, Enan G1, Osman A. (PubMed)
#Herbal Turmeric's #Curcumin Processes a Strong Immunodulatroy Activity Against Bacterial Infection through Its Antioxidant Activity, Researchers Say
Kyle J. Norton
The immunomodulatory activity is a process in which the immune function is modulated to the needs of the body.
The immune system including the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
Immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with an underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as an autoimmune disease. In this case, patients suffer diseases associated with the immune system that attack the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulate the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occur within a short period of time such as hours of pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in a set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory diseases, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the enhancement of the immune system, researchers examined the effects of turmeric on immunomodulating activity.
Carp (average weight: 16.37 g) selected for the study were fed by four various concentrations of curcumin (g Kg-1): 0 g [basal diet], 5 g [T5], 10 g [T10], and 15 g [T15] were fed to the carp (average weight: 16.37 g) for 8 weeks.
According to the skin mucosal immune parameters examination, T15 fed with 15 g curcumin showed significantly higher levels of lysozyme (36.8 ± 4.03 U mL-1) involved bacterial infections, total immunoglobulin (6.74 ± 0.5 mg mL-1, antibodies), protein level (18.7 ± 1.62 mg mL-1), alkaline phosphatase (96.37 ± 6.3 IU L-1), and protease activity (9.47 ± 0.82%) associated with the innate immune response.
Furthermore, levels of antioxidants such as superoxide dismutase (SOD) and catalase (CAT) activities were higher in T10 or T15, compared to the control.
Moreover, groups treated with curcumin also reduced tissue oxidative stress such as malondialdehyde level was decreased significantly.
More precisely, T10 and T15 exhibited immunomodulatory activity by enhancing the expression of antioxidant genes (SOD, CAT, nuclear factor erythroid 2-related factor 2) and anti-inflammatory cytokine Interleukin-10 and inhibiting the expression of pro-inflammatory cytokines such as IL-1β, tumor necrosis factor-alpha in the tested subjects.
Based on the findings, researchers wrote, "suggest that dietary supplements of curcumin at 15 g Kg-1can significantly improve the growth performance, skin mucosal and serum antioxidant parameters, and strengthen the immunity of C. Carpio".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of immunomodulatory properties, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How to Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Immunomodulatory effects of turmeric: Proliferation of spleen cells in mice by Mustafa R1,2, Blumenthal E. (PubMed)
(2) Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio by Giri SS1, Sukumaran V2, Park SC. (PubMed)
(3) The Western diet: an examination of its relationship with chronic disease by Klurfeld DM, Kritchevsky D. (PubMed)
The immunomodulatory activity is a process in which the immune function is modulated to the needs of the body.
The immune system including the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
Immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with an underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as an autoimmune disease. In this case, patients suffer diseases associated with the immune system that attack the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulate the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occur within a short period of time such as hours of pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in a set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory diseases, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the enhancement of the immune system, researchers examined the effects of turmeric on immunomodulating activity.
Carp (average weight: 16.37 g) selected for the study were fed by four various concentrations of curcumin (g Kg-1): 0 g [basal diet], 5 g [T5], 10 g [T10], and 15 g [T15] were fed to the carp (average weight: 16.37 g) for 8 weeks.
According to the skin mucosal immune parameters examination, T15 fed with 15 g curcumin showed significantly higher levels of lysozyme (36.8 ± 4.03 U mL-1) involved bacterial infections, total immunoglobulin (6.74 ± 0.5 mg mL-1, antibodies), protein level (18.7 ± 1.62 mg mL-1), alkaline phosphatase (96.37 ± 6.3 IU L-1), and protease activity (9.47 ± 0.82%) associated with the innate immune response.
Furthermore, levels of antioxidants such as superoxide dismutase (SOD) and catalase (CAT) activities were higher in T10 or T15, compared to the control.
Moreover, groups treated with curcumin also reduced tissue oxidative stress such as malondialdehyde level was decreased significantly.
More precisely, T10 and T15 exhibited immunomodulatory activity by enhancing the expression of antioxidant genes (SOD, CAT, nuclear factor erythroid 2-related factor 2) and anti-inflammatory cytokine Interleukin-10 and inhibiting the expression of pro-inflammatory cytokines such as IL-1β, tumor necrosis factor-alpha in the tested subjects.
Based on the findings, researchers wrote, "suggest that dietary supplements of curcumin at 15 g Kg-1can significantly improve the growth performance, skin mucosal and serum antioxidant parameters, and strengthen the immunity of C. Carpio".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of immunomodulatory properties, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How to Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Immunomodulatory effects of turmeric: Proliferation of spleen cells in mice by Mustafa R1,2, Blumenthal E. (PubMed)
(2) Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio by Giri SS1, Sukumaran V2, Park SC. (PubMed)
(3) The Western diet: an examination of its relationship with chronic disease by Klurfeld DM, Kritchevsky D. (PubMed)
Phytochemical DIM Found in #BrassicaRapa Vegetable Exerts Renoprotective Effects Against Kidney Damage and Injury, Researchers Say
Kyle J. Norton
Kidneys, a pair of bean-shaped organ in the human body not only filter out blood but also balances body fluids by eliminating them and removing them through urinary secretion.
Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.
Kidney disease is a medical condition associated with a gradually reduced function of the kidney.
Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.
* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, and fluid retention, that lead to swelling in the legs, ankles, or feet, fatigue, nausea, and physical weakness
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Renal toxicity or nephrotoxicity in most cases is toxicity in the kidneys caused by toxic chemicals and medications.
The most common symptoms of renal toxicity may cause reduced kidney function in eliminating toxins, leading to a reduced amount of urine. swelling of your legs, ankles, and feet from retention of fluids.
In a serious case, the condition can also result in unexplained shortness of breath. excessive drowsiness or fatigue. persistent nausea. confusion. pain or pressure in your chest.
Depending on the severity of kidney damage, kidney disease can range from mild to severe, including kidney failure.
With an aim to find a natural food for the prevention and treatment of renal diseases, researchers examined the effect of 3,3'‑Diindolylmethane (DIM), a naturally derived indole compound found in the Brassica family of vegetables on kidney injury.
The study included male BALB/c mouse models of AKI that were established using intraperitoneal injections of 10 mg/kg LPS followed by the DIM (40 mg/kg) administered intraperitoneally 24 and 2 h before LPS exposure.
According to the tested analysis,
* DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine.
* DIM also suppressed the LPS‑induced production of reactive oxygen species in the induction of cell apoptosis.
* DIM treatment also significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 which results in oxidative stress in LPS‑treated mice.
More precisely, DIM protected the kidney cell integrity against all parameters expressed by the injection of LPS.
Based on the results, researchers wrote, " Therefore, DIM may exert its renoprotective actions by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells"
Taken together, Brassica rapa vegetables may be considered supplements for the prevention of kidney injury, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'‑Diindolylmethane mitigates lipopolysaccharide‑induced acute kidney injury in mice by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells by He J1, Huang T2, Zhao L. (PubMed)
Kidneys, a pair of bean-shaped organ in the human body not only filter out blood but also balances body fluids by eliminating them and removing them through urinary secretion.
Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.
Kidney disease is a medical condition associated with a gradually reduced function of the kidney.
Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.
* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, and fluid retention, that lead to swelling in the legs, ankles, or feet, fatigue, nausea, and physical weakness
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Renal toxicity or nephrotoxicity in most cases is toxicity in the kidneys caused by toxic chemicals and medications.
The most common symptoms of renal toxicity may cause reduced kidney function in eliminating toxins, leading to a reduced amount of urine. swelling of your legs, ankles, and feet from retention of fluids.
In a serious case, the condition can also result in unexplained shortness of breath. excessive drowsiness or fatigue. persistent nausea. confusion. pain or pressure in your chest.
Depending on the severity of kidney damage, kidney disease can range from mild to severe, including kidney failure.
With an aim to find a natural food for the prevention and treatment of renal diseases, researchers examined the effect of 3,3'‑Diindolylmethane (DIM), a naturally derived indole compound found in the Brassica family of vegetables on kidney injury.
The study included male BALB/c mouse models of AKI that were established using intraperitoneal injections of 10 mg/kg LPS followed by the DIM (40 mg/kg) administered intraperitoneally 24 and 2 h before LPS exposure.
According to the tested analysis,
* DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine.
* DIM also suppressed the LPS‑induced production of reactive oxygen species in the induction of cell apoptosis.
* DIM treatment also significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 which results in oxidative stress in LPS‑treated mice.
More precisely, DIM protected the kidney cell integrity against all parameters expressed by the injection of LPS.
Based on the results, researchers wrote, " Therefore, DIM may exert its renoprotective actions by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells"
Taken together, Brassica rapa vegetables may be considered supplements for the prevention of kidney injury, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'‑Diindolylmethane mitigates lipopolysaccharide‑induced acute kidney injury in mice by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells by He J1, Huang T2, Zhao L. (PubMed)
P-CoumaricAcid (CA) Found in #Turnip Protect the Integrity of the Lung Epithelial B arrier Against Hypoxia, Researchers Suggest
Kyle J. Norton
Hypoxia is an urgent medical emergency of deficiency in the amount of oxygen reaching the tissues.
In other words, if your body does not get enough oxygen, you might get hypoxia. The condition has been found to induce brain, liver, and other organs damaged just minutes after symptoms start.
The most common symptoms of hypoxia are associated with a lack of oxygen that reaches the organs and tissues, including changes in the color of the skin, ranging from blue to cherry red, confusion, cough, increased heart rate, rapid breathing, and shortness of breath.
The most common risk factors associated with the onset of hypoxia are damage to the lung due to trauma, medical conditions such as an asthma attack, lung diseases such as chronic obstructive pulmonary disease (COPD), emphysema, bronchitis, pneumonia, pulmonary edema, intake of certain medications that hold back breathing and people with severe anemia.
The most common treatment for hypoxia is to withdraw medications that cause the condition and give additional oxygen to the patient quickly. Almost all patients respond to additional oxygen supplied by a nasal cannula.
Tibetan turnip (Brassica rapa L.), native to the Tibet region, is a medical plant used in Tibet as a “tonic and anti-hypoxia” “heat-clearing and detoxification” and “alleviating fatigue” herbal medications.
In finding a potential compound for the treatment of hypoxia, researchers conducted a joint study led by Zhejiang University on an animal model.
Selected male ICR mice included in the study were assigned to the normoxia group and several hypoxia groups, given sterile water, p-coumaric acid (CA), or dexamethasone orally, once daily for four consecutive days.
Based on the results of the analysis in a hypoxic environment of 9.5% O2,, mice treated with 100 mg/kg body wt CA showed a significantly lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF) content than mice in the hypoxia vehicle group.
Where lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF)content are the symptoms of the deficient amount of oxygen in the lung.
Moreover, mice treated with CA also protect the lung functioning by showing an intact lung blood gas barrier, increased levels of plasma total NO,
Additionally, levels of preproendothelin-1 (PPET1), associated with vasoconstriction also decreased in the CA treatment group.
More importantly, CA induced the production of occludin, a tight junction protein in maintaining the integrity of the lung epithelial barrier against hypoxia.
Taken together, turnip may be considered herbal medicine for the prevention and treatment of hypoxia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) p-Coumaric acid as a prophylactic measure against normobaric hypoxia-induced pulmonary edema in mice by Li Y1, Han J1, Chen Y1, Chen C1, Chu B2, Zhang Y. (PubMed)
Hypoxia is an urgent medical emergency of deficiency in the amount of oxygen reaching the tissues.
In other words, if your body does not get enough oxygen, you might get hypoxia. The condition has been found to induce brain, liver, and other organs damaged just minutes after symptoms start.
The most common symptoms of hypoxia are associated with a lack of oxygen that reaches the organs and tissues, including changes in the color of the skin, ranging from blue to cherry red, confusion, cough, increased heart rate, rapid breathing, and shortness of breath.
The most common risk factors associated with the onset of hypoxia are damage to the lung due to trauma, medical conditions such as an asthma attack, lung diseases such as chronic obstructive pulmonary disease (COPD), emphysema, bronchitis, pneumonia, pulmonary edema, intake of certain medications that hold back breathing and people with severe anemia.
The most common treatment for hypoxia is to withdraw medications that cause the condition and give additional oxygen to the patient quickly. Almost all patients respond to additional oxygen supplied by a nasal cannula.
Tibetan turnip (Brassica rapa L.), native to the Tibet region, is a medical plant used in Tibet as a “tonic and anti-hypoxia” “heat-clearing and detoxification” and “alleviating fatigue” herbal medications.
In finding a potential compound for the treatment of hypoxia, researchers conducted a joint study led by Zhejiang University on an animal model.
Selected male ICR mice included in the study were assigned to the normoxia group and several hypoxia groups, given sterile water, p-coumaric acid (CA), or dexamethasone orally, once daily for four consecutive days.
Based on the results of the analysis in a hypoxic environment of 9.5% O2,, mice treated with 100 mg/kg body wt CA showed a significantly lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF) content than mice in the hypoxia vehicle group.
Where lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF)content are the symptoms of the deficient amount of oxygen in the lung.
Moreover, mice treated with CA also protect the lung functioning by showing an intact lung blood gas barrier, increased levels of plasma total NO,
Additionally, levels of preproendothelin-1 (PPET1), associated with vasoconstriction also decreased in the CA treatment group.
More importantly, CA induced the production of occludin, a tight junction protein in maintaining the integrity of the lung epithelial barrier against hypoxia.
Taken together, turnip may be considered herbal medicine for the prevention and treatment of hypoxia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) p-Coumaric acid as a prophylactic measure against normobaric hypoxia-induced pulmonary edema in mice by Li Y1, Han J1, Chen Y1, Chen C1, Chu B2, Zhang Y. (PubMed)
Friday, 8 September 2023
#Phytochemical #Betanin Found in #Beetroot Exhibits the Production of #AntioxidantEnzymes in the Body, Researchers Say
Kyle J. Norton
Reactive oxidative species or ROS are chemically reactive atoms containing oxygen
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stability, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading to a domino effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid, and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body's functioning, including vascular relaxation.
Balancing the ratio of free radicals and antioxidants may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
, "Further, at adequate free-radical concentrations, a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitors may someday be used for medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation, and aging.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot's major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in initiating cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, with side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO and restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues by stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "The potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered a supplement for the prevention of the overexpression of ROS, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage, and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate-induced cytotoxicity in primary hepatocytes via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
Reactive oxidative species or ROS are chemically reactive atoms containing oxygen
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stability, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading to a domino effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid, and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body's functioning, including vascular relaxation.
Balancing the ratio of free radicals and antioxidants may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
, "Further, at adequate free-radical concentrations, a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitors may someday be used for medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation, and aging.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot's major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in initiating cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, with side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO and restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues by stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "The potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered a supplement for the prevention of the overexpression of ROS, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage, and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate-induced cytotoxicity in primary hepatocytes via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
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