Kyle J. Norton
Infectious diseases are medical conditions caused by pathogenic microorganisms, including bacteria, viruses, parasites, or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistics provided by the World Health Organization, infectious diseases were ranked in the top ten causes of death worldwide in 2016.
A bacterial infection is an infected caused bacteria.
Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulate the production of blood palette to cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.
However, the overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damaged the nearby healthy cells, leading to the formation of scars.
In most cases in a healthy individual, depending on the size of the wound, the immune system can easily eradicate all foreign invaders, and the wound is recovered within days and weeks.
Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, diarrhea, short-term joint or muscle pain, fever, headache, skin rash, and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.
The most common types of bacterial infections are bacterial meningitis, otitis media, pneumonia, and tuberculosis.
Roselle (Hibiscus sabdariffa) is a species of Hibiscus probably native to West Africa used in traditional Chinese medicine to resolve phlegm and food stagnation and regulate the Liver to aid digestion, promote weight loss, reduce cholesterol, improve circulation, and lower blood pressure.
With an aim to find natural food for the treatment of infectious diseases,, researchers compared the effects of rude, phenolic-rich extracts (CPREs) isolated from different sources, such as Hibiscus sabdariffa (H. sabdariffa, Roselle), Brassica oleracea var. capitata f. Rubra (B. oleracea, red cabbage) and Beta vulgaris (B. Vulgaris).
According to the tested differentiation, the administration of CPREs showed potential antibacterial and antifungal activities.
According to chemical analysis, total anthocyanins content (TAC), total phenolic content (TPC), total flavonoid content (TFC), and other compounds found in all three CPREs demonstrated strong antimicrobial effects against pathogenic bacteria and fungi.
Hibiscus sabdariffa CPRE (HCPRE) at a dose of 50 μg/mL exhibited signs of asymmetric, wrinkled exterior surfaces, cell deformations, and loss of cell shapes against Staphylococcus aureus DSM 1104 and Klebsiella pneumonia ATCC 43816.
The injection of CPRE also led to cell clumping, malformations, blisters, cell depressions, and diminished cell numbers.
In other words, CPRE induced the death of bacterial cells and loss of cell contents.
Taken altogether, Hibiscus sabdariffa may be considered a remedy for the prevention and treatment of infectious diseases, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antimicrobial Activity and Chemical Constitution of the Crude, Phenolic-Rich Extracts of Hibiscus sabdariffa, Brassica oleracea, and Beta vulgaris by Abdel-Shafi S1, Al-Mohammadi AR2, Sitohy M3, Mosa B1, Ismaiel A1, Enan G1, Osman A. (PubMed)
Saturday, 9 September 2023
#Herbal Turmeric's #Curcumin Processes a Strong Immunodulatroy Activity Against Bacterial Infection through Its Antioxidant Activity, Researchers Say
Kyle J. Norton
The immunomodulatory activity is a process in which the immune function is modulated to the needs of the body.
The immune system including the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
Immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with an underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as an autoimmune disease. In this case, patients suffer diseases associated with the immune system that attack the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulate the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occur within a short period of time such as hours of pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in a set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory diseases, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the enhancement of the immune system, researchers examined the effects of turmeric on immunomodulating activity.
Carp (average weight: 16.37 g) selected for the study were fed by four various concentrations of curcumin (g Kg-1): 0 g [basal diet], 5 g [T5], 10 g [T10], and 15 g [T15] were fed to the carp (average weight: 16.37 g) for 8 weeks.
According to the skin mucosal immune parameters examination, T15 fed with 15 g curcumin showed significantly higher levels of lysozyme (36.8 ± 4.03 U mL-1) involved bacterial infections, total immunoglobulin (6.74 ± 0.5 mg mL-1, antibodies), protein level (18.7 ± 1.62 mg mL-1), alkaline phosphatase (96.37 ± 6.3 IU L-1), and protease activity (9.47 ± 0.82%) associated with the innate immune response.
Furthermore, levels of antioxidants such as superoxide dismutase (SOD) and catalase (CAT) activities were higher in T10 or T15, compared to the control.
Moreover, groups treated with curcumin also reduced tissue oxidative stress such as malondialdehyde level was decreased significantly.
More precisely, T10 and T15 exhibited immunomodulatory activity by enhancing the expression of antioxidant genes (SOD, CAT, nuclear factor erythroid 2-related factor 2) and anti-inflammatory cytokine Interleukin-10 and inhibiting the expression of pro-inflammatory cytokines such as IL-1β, tumor necrosis factor-alpha in the tested subjects.
Based on the findings, researchers wrote, "suggest that dietary supplements of curcumin at 15 g Kg-1can significantly improve the growth performance, skin mucosal and serum antioxidant parameters, and strengthen the immunity of C. Carpio".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of immunomodulatory properties, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How to Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Immunomodulatory effects of turmeric: Proliferation of spleen cells in mice by Mustafa R1,2, Blumenthal E. (PubMed)
(2) Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio by Giri SS1, Sukumaran V2, Park SC. (PubMed)
(3) The Western diet: an examination of its relationship with chronic disease by Klurfeld DM, Kritchevsky D. (PubMed)
The immunomodulatory activity is a process in which the immune function is modulated to the needs of the body.
The immune system including the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
Immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with an underactive immune system are susceptible to infection, recurrent infections.
* The overactive immune system is also known as an autoimmune disease. In this case, patients suffer diseases associated with the immune system that attack the body tissues.
In the acute phase of infection, the immune macrophages, the first line of defense stimulate the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.
Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.
The most common symptoms of acute inflammation occur within a short period of time such as hours of pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in a set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.
Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory diseases, including diabetes, arthritis, and cardiovascular disease.
Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.
Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".
And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".
In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the enhancement of the immune system, researchers examined the effects of turmeric on immunomodulating activity.
Carp (average weight: 16.37 g) selected for the study were fed by four various concentrations of curcumin (g Kg-1): 0 g [basal diet], 5 g [T5], 10 g [T10], and 15 g [T15] were fed to the carp (average weight: 16.37 g) for 8 weeks.
According to the skin mucosal immune parameters examination, T15 fed with 15 g curcumin showed significantly higher levels of lysozyme (36.8 ± 4.03 U mL-1) involved bacterial infections, total immunoglobulin (6.74 ± 0.5 mg mL-1, antibodies), protein level (18.7 ± 1.62 mg mL-1), alkaline phosphatase (96.37 ± 6.3 IU L-1), and protease activity (9.47 ± 0.82%) associated with the innate immune response.
Furthermore, levels of antioxidants such as superoxide dismutase (SOD) and catalase (CAT) activities were higher in T10 or T15, compared to the control.
Moreover, groups treated with curcumin also reduced tissue oxidative stress such as malondialdehyde level was decreased significantly.
More precisely, T10 and T15 exhibited immunomodulatory activity by enhancing the expression of antioxidant genes (SOD, CAT, nuclear factor erythroid 2-related factor 2) and anti-inflammatory cytokine Interleukin-10 and inhibiting the expression of pro-inflammatory cytokines such as IL-1β, tumor necrosis factor-alpha in the tested subjects.
Based on the findings, researchers wrote, "suggest that dietary supplements of curcumin at 15 g Kg-1can significantly improve the growth performance, skin mucosal and serum antioxidant parameters, and strengthen the immunity of C. Carpio".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of immunomodulatory properties, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How to Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Immunomodulatory effects of turmeric: Proliferation of spleen cells in mice by Mustafa R1,2, Blumenthal E. (PubMed)
(2) Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio by Giri SS1, Sukumaran V2, Park SC. (PubMed)
(3) The Western diet: an examination of its relationship with chronic disease by Klurfeld DM, Kritchevsky D. (PubMed)
Phytochemical DIM Found in #BrassicaRapa Vegetable Exerts Renoprotective Effects Against Kidney Damage and Injury, Researchers Say
Kyle J. Norton
Kidneys, a pair of bean-shaped organ in the human body not only filter out blood but also balances body fluids by eliminating them and removing them through urinary secretion.
Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.
Kidney disease is a medical condition associated with a gradually reduced function of the kidney.
Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.
* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, and fluid retention, that lead to swelling in the legs, ankles, or feet, fatigue, nausea, and physical weakness
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Renal toxicity or nephrotoxicity in most cases is toxicity in the kidneys caused by toxic chemicals and medications.
The most common symptoms of renal toxicity may cause reduced kidney function in eliminating toxins, leading to a reduced amount of urine. swelling of your legs, ankles, and feet from retention of fluids.
In a serious case, the condition can also result in unexplained shortness of breath. excessive drowsiness or fatigue. persistent nausea. confusion. pain or pressure in your chest.
Depending on the severity of kidney damage, kidney disease can range from mild to severe, including kidney failure.
With an aim to find a natural food for the prevention and treatment of renal diseases, researchers examined the effect of 3,3'‑Diindolylmethane (DIM), a naturally derived indole compound found in the Brassica family of vegetables on kidney injury.
The study included male BALB/c mouse models of AKI that were established using intraperitoneal injections of 10 mg/kg LPS followed by the DIM (40 mg/kg) administered intraperitoneally 24 and 2 h before LPS exposure.
According to the tested analysis,
* DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine.
* DIM also suppressed the LPS‑induced production of reactive oxygen species in the induction of cell apoptosis.
* DIM treatment also significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 which results in oxidative stress in LPS‑treated mice.
More precisely, DIM protected the kidney cell integrity against all parameters expressed by the injection of LPS.
Based on the results, researchers wrote, " Therefore, DIM may exert its renoprotective actions by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells"
Taken together, Brassica rapa vegetables may be considered supplements for the prevention of kidney injury, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'‑Diindolylmethane mitigates lipopolysaccharide‑induced acute kidney injury in mice by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells by He J1, Huang T2, Zhao L. (PubMed)
Kidneys, a pair of bean-shaped organ in the human body not only filter out blood but also balances body fluids by eliminating them and removing them through urinary secretion.
Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.
Kidney disease is a medical condition associated with a gradually reduced function of the kidney.
Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.
* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, and fluid retention, that lead to swelling in the legs, ankles, or feet, fatigue, nausea, and physical weakness
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Renal toxicity or nephrotoxicity in most cases is toxicity in the kidneys caused by toxic chemicals and medications.
The most common symptoms of renal toxicity may cause reduced kidney function in eliminating toxins, leading to a reduced amount of urine. swelling of your legs, ankles, and feet from retention of fluids.
In a serious case, the condition can also result in unexplained shortness of breath. excessive drowsiness or fatigue. persistent nausea. confusion. pain or pressure in your chest.
Depending on the severity of kidney damage, kidney disease can range from mild to severe, including kidney failure.
With an aim to find a natural food for the prevention and treatment of renal diseases, researchers examined the effect of 3,3'‑Diindolylmethane (DIM), a naturally derived indole compound found in the Brassica family of vegetables on kidney injury.
The study included male BALB/c mouse models of AKI that were established using intraperitoneal injections of 10 mg/kg LPS followed by the DIM (40 mg/kg) administered intraperitoneally 24 and 2 h before LPS exposure.
According to the tested analysis,
* DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine.
* DIM also suppressed the LPS‑induced production of reactive oxygen species in the induction of cell apoptosis.
* DIM treatment also significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 which results in oxidative stress in LPS‑treated mice.
More precisely, DIM protected the kidney cell integrity against all parameters expressed by the injection of LPS.
Based on the results, researchers wrote, " Therefore, DIM may exert its renoprotective actions by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells"
Taken together, Brassica rapa vegetables may be considered supplements for the prevention of kidney injury, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'‑Diindolylmethane mitigates lipopolysaccharide‑induced acute kidney injury in mice by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells by He J1, Huang T2, Zhao L. (PubMed)
P-CoumaricAcid (CA) Found in #Turnip Protect the Integrity of the Lung Epithelial B arrier Against Hypoxia, Researchers Suggest
Kyle J. Norton
Hypoxia is an urgent medical emergency of deficiency in the amount of oxygen reaching the tissues.
In other words, if your body does not get enough oxygen, you might get hypoxia. The condition has been found to induce brain, liver, and other organs damaged just minutes after symptoms start.
The most common symptoms of hypoxia are associated with a lack of oxygen that reaches the organs and tissues, including changes in the color of the skin, ranging from blue to cherry red, confusion, cough, increased heart rate, rapid breathing, and shortness of breath.
The most common risk factors associated with the onset of hypoxia are damage to the lung due to trauma, medical conditions such as an asthma attack, lung diseases such as chronic obstructive pulmonary disease (COPD), emphysema, bronchitis, pneumonia, pulmonary edema, intake of certain medications that hold back breathing and people with severe anemia.
The most common treatment for hypoxia is to withdraw medications that cause the condition and give additional oxygen to the patient quickly. Almost all patients respond to additional oxygen supplied by a nasal cannula.
Tibetan turnip (Brassica rapa L.), native to the Tibet region, is a medical plant used in Tibet as a “tonic and anti-hypoxia” “heat-clearing and detoxification” and “alleviating fatigue” herbal medications.
In finding a potential compound for the treatment of hypoxia, researchers conducted a joint study led by Zhejiang University on an animal model.
Selected male ICR mice included in the study were assigned to the normoxia group and several hypoxia groups, given sterile water, p-coumaric acid (CA), or dexamethasone orally, once daily for four consecutive days.
Based on the results of the analysis in a hypoxic environment of 9.5% O2,, mice treated with 100 mg/kg body wt CA showed a significantly lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF) content than mice in the hypoxia vehicle group.
Where lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF)content are the symptoms of the deficient amount of oxygen in the lung.
Moreover, mice treated with CA also protect the lung functioning by showing an intact lung blood gas barrier, increased levels of plasma total NO,
Additionally, levels of preproendothelin-1 (PPET1), associated with vasoconstriction also decreased in the CA treatment group.
More importantly, CA induced the production of occludin, a tight junction protein in maintaining the integrity of the lung epithelial barrier against hypoxia.
Taken together, turnip may be considered herbal medicine for the prevention and treatment of hypoxia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) p-Coumaric acid as a prophylactic measure against normobaric hypoxia-induced pulmonary edema in mice by Li Y1, Han J1, Chen Y1, Chen C1, Chu B2, Zhang Y. (PubMed)
Hypoxia is an urgent medical emergency of deficiency in the amount of oxygen reaching the tissues.
In other words, if your body does not get enough oxygen, you might get hypoxia. The condition has been found to induce brain, liver, and other organs damaged just minutes after symptoms start.
The most common symptoms of hypoxia are associated with a lack of oxygen that reaches the organs and tissues, including changes in the color of the skin, ranging from blue to cherry red, confusion, cough, increased heart rate, rapid breathing, and shortness of breath.
The most common risk factors associated with the onset of hypoxia are damage to the lung due to trauma, medical conditions such as an asthma attack, lung diseases such as chronic obstructive pulmonary disease (COPD), emphysema, bronchitis, pneumonia, pulmonary edema, intake of certain medications that hold back breathing and people with severe anemia.
The most common treatment for hypoxia is to withdraw medications that cause the condition and give additional oxygen to the patient quickly. Almost all patients respond to additional oxygen supplied by a nasal cannula.
Tibetan turnip (Brassica rapa L.), native to the Tibet region, is a medical plant used in Tibet as a “tonic and anti-hypoxia” “heat-clearing and detoxification” and “alleviating fatigue” herbal medications.
In finding a potential compound for the treatment of hypoxia, researchers conducted a joint study led by Zhejiang University on an animal model.
Selected male ICR mice included in the study were assigned to the normoxia group and several hypoxia groups, given sterile water, p-coumaric acid (CA), or dexamethasone orally, once daily for four consecutive days.
Based on the results of the analysis in a hypoxic environment of 9.5% O2,, mice treated with 100 mg/kg body wt CA showed a significantly lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF) content than mice in the hypoxia vehicle group.
Where lower lung water content (LWC), and the protein content of bronchoalveolar lavage fluid (BALF)content are the symptoms of the deficient amount of oxygen in the lung.
Moreover, mice treated with CA also protect the lung functioning by showing an intact lung blood gas barrier, increased levels of plasma total NO,
Additionally, levels of preproendothelin-1 (PPET1), associated with vasoconstriction also decreased in the CA treatment group.
More importantly, CA induced the production of occludin, a tight junction protein in maintaining the integrity of the lung epithelial barrier against hypoxia.
Taken together, turnip may be considered herbal medicine for the prevention and treatment of hypoxia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) p-Coumaric acid as a prophylactic measure against normobaric hypoxia-induced pulmonary edema in mice by Li Y1, Han J1, Chen Y1, Chen C1, Chu B2, Zhang Y. (PubMed)
Friday, 8 September 2023
#Phytochemical #Betanin Found in #Beetroot Exhibits the Production of #AntioxidantEnzymes in the Body, Researchers Say
Kyle J. Norton
Reactive oxidative species or ROS are chemically reactive atoms containing oxygen
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stability, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading to a domino effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid, and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body's functioning, including vascular relaxation.
Balancing the ratio of free radicals and antioxidants may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
, "Further, at adequate free-radical concentrations, a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitors may someday be used for medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation, and aging.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot's major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in initiating cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, with side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO and restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues by stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "The potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered a supplement for the prevention of the overexpression of ROS, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage, and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate-induced cytotoxicity in primary hepatocytes via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
Reactive oxidative species or ROS are chemically reactive atoms containing oxygen
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stability, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading to a domino effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid, and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body's functioning, including vascular relaxation.
Balancing the ratio of free radicals and antioxidants may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
, "Further, at adequate free-radical concentrations, a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitors may someday be used for medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation, and aging.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot's major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in initiating cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, with side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO and restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues by stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "The potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered a supplement for the prevention of the overexpression of ROS, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage, and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate-induced cytotoxicity in primary hepatocytes via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
Tuesday, 5 September 2023
#Ginger Improves Kidney Function and Parameters Associated with Diabetic Symptoms, According to Studies
Kyle J. Norton
Ginger may be considered a functional food for the prevention and treatment of hyperlipidemia without inducing side effects, some scientists found.
Hyperlipidemia is a condition of abnormally high blood cholesterol.
In other words, people with hyperlipidemia have an elevated ratio of low-density lipoprotein/ high-density lipoprotein.
The normal and healthy ratio of healthy blood cholesterol is lower than 4/1.
The most common causes of high blood cholesterol are an unhealthy diet with high saturated and trans fat, red meat and processed foods, and few in fruits and vegetables.
In fact, low intake of high-density lipoproteins has the unique function of transporting the excess cholesterol back to the liver.
In other words, the presence of high-density lipoproteins reduces the bad blood cholesterol in the bloodstream, thus decreasing the formation of plaque accumulated in the arterial wall, the major risk of heart disease.
Some researchers suggested that genetic predisposition and certain medical conditions such as diabetes mellitus, kidney disease, and hypothyroidism may also increase the risk of hyperlipidemia.
The most common types of high-density lipoproteins can be found in olive oil which has been found to lower the inflammatory impact of LDL cholesterol on the body, beans, legumes, whole grains. ... high-fiber fruit, and deep-sea fatty fish.
Therefore, by topical 2 spoonfuls of olive oil to your lunch salad every day, you may kiss the hypercholesterol goodbye after six months.
Why it takes so long? Because olive oil is a food and fat, not Western single-ingredient medicine.
Dr. Cullinen K in the nutrition team at the Rhode Island Department of Health, said, "Olive oil consumption increases HDL-cholesterol levels while decreasing LDL-cholesterol levels, LDL susceptibility to oxidation and lipid peroxidation".
And, "The reduction of cellular oxidative stress, thrombogenicity and the formation of atheroma plague can explain the preventive effects of olive oil on atherosclerosis development".
These results clearly supported the use of oiler oil for the treatment of patients with hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the treatment of abnormally high blood cholesterol with no side effects, researchers at the Tehran University of Medical Sciences assessed the effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial included 70 type 2 diabetic patients allocated randomly into the ginger group and control group.
The treatment group consumed 1600 mg ginger versus 1600 mg wheat flour consumed by the placebo daily for 12 weeks.
At the end of the trial, researchers showed that the ginger treatment group exerted a significantly reduced fasting plasma glucose, HbA1C, insulin resistance, HOMA, triglyceride, total cholesterol, CRP, and PGE₂, compared to the placebo group.
However, there were no significant differences in HDL, LD, and TNFα between the two groups.
These results clearly suggested ginger has a strong effect in improving all parameters associated with diabetic symptoms.
Dr. Arablou T in the final report said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients".
Other researchers concerned of oxidative stress in the development and progression of diabetic nephropathy (DN)launched an investigation to examine the potential protective effect of ginger (Zingiber officinale) rhizome extract on hyperglycemia-induced oxidative stress, inflammation, and apoptosis.
Diabetes rats selected for the study were given 400 or 800 mg/kg/day Z. officinale extract for six weeks orally.
Treatment with Z. officinale not only improved all diabetic symptoms but also ameliorated hyperglycemia, hyperlipidemia, and kidney function.
In addition, Z. officinale minimized the histological alterations in the kidneys of diabetic rats
The evidence indicated Z. officinale extract significantly attenuated oxidative stress, inflammation and apoptosis, and enhanced antioxidant defenses in the diabetic kidney.
Taken together, ginger may be considered a functional food for the prevention and treatment of abnormally high blood cholesterol with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS. by Eissa FA1, Choudhry H1,2,3, Abdulaal WH1,3, Baothman OA1, Zeyadi M1, Moselhy SS1,4,5,6, Zamzami MA1,2. (PubMed)
(3) Ginger alleviates hyperglycemia-induced oxidative stress, inflammation, and apoptosis and protects rats against diabetic nephropathy by Al Hroob AM1, Abukhalil MH2, Alghonmeen RD3, Mahmoud AM4. (PubMed)
(4) Olive oil in the treatment of hypercholesterolemia by Cullinen K. (PubMed)
Ginger may be considered a functional food for the prevention and treatment of hyperlipidemia without inducing side effects, some scientists found.
Hyperlipidemia is a condition of abnormally high blood cholesterol.
In other words, people with hyperlipidemia have an elevated ratio of low-density lipoprotein/ high-density lipoprotein.
The normal and healthy ratio of healthy blood cholesterol is lower than 4/1.
The most common causes of high blood cholesterol are an unhealthy diet with high saturated and trans fat, red meat and processed foods, and few in fruits and vegetables.
In fact, low intake of high-density lipoproteins has the unique function of transporting the excess cholesterol back to the liver.
In other words, the presence of high-density lipoproteins reduces the bad blood cholesterol in the bloodstream, thus decreasing the formation of plaque accumulated in the arterial wall, the major risk of heart disease.
Some researchers suggested that genetic predisposition and certain medical conditions such as diabetes mellitus, kidney disease, and hypothyroidism may also increase the risk of hyperlipidemia.
The most common types of high-density lipoproteins can be found in olive oil which has been found to lower the inflammatory impact of LDL cholesterol on the body, beans, legumes, whole grains. ... high-fiber fruit, and deep-sea fatty fish.
Therefore, by topical 2 spoonfuls of olive oil to your lunch salad every day, you may kiss the hypercholesterol goodbye after six months.
Why it takes so long? Because olive oil is a food and fat, not Western single-ingredient medicine.
Dr. Cullinen K in the nutrition team at the Rhode Island Department of Health, said, "Olive oil consumption increases HDL-cholesterol levels while decreasing LDL-cholesterol levels, LDL susceptibility to oxidation and lipid peroxidation".
And, "The reduction of cellular oxidative stress, thrombogenicity and the formation of atheroma plague can explain the preventive effects of olive oil on atherosclerosis development".
These results clearly supported the use of oiler oil for the treatment of patients with hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the treatment of abnormally high blood cholesterol with no side effects, researchers at the Tehran University of Medical Sciences assessed the effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial included 70 type 2 diabetic patients allocated randomly into the ginger group and control group.
The treatment group consumed 1600 mg ginger versus 1600 mg wheat flour consumed by the placebo daily for 12 weeks.
At the end of the trial, researchers showed that the ginger treatment group exerted a significantly reduced fasting plasma glucose, HbA1C, insulin resistance, HOMA, triglyceride, total cholesterol, CRP, and PGE₂, compared to the placebo group.
However, there were no significant differences in HDL, LD, and TNFα between the two groups.
These results clearly suggested ginger has a strong effect in improving all parameters associated with diabetic symptoms.
Dr. Arablou T in the final report said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients".
Other researchers concerned of oxidative stress in the development and progression of diabetic nephropathy (DN)launched an investigation to examine the potential protective effect of ginger (Zingiber officinale) rhizome extract on hyperglycemia-induced oxidative stress, inflammation, and apoptosis.
Diabetes rats selected for the study were given 400 or 800 mg/kg/day Z. officinale extract for six weeks orally.
Treatment with Z. officinale not only improved all diabetic symptoms but also ameliorated hyperglycemia, hyperlipidemia, and kidney function.
In addition, Z. officinale minimized the histological alterations in the kidneys of diabetic rats
The evidence indicated Z. officinale extract significantly attenuated oxidative stress, inflammation and apoptosis, and enhanced antioxidant defenses in the diabetic kidney.
Taken together, ginger may be considered a functional food for the prevention and treatment of abnormally high blood cholesterol with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS. by Eissa FA1, Choudhry H1,2,3, Abdulaal WH1,3, Baothman OA1, Zeyadi M1, Moselhy SS1,4,5,6, Zamzami MA1,2. (PubMed)
(3) Ginger alleviates hyperglycemia-induced oxidative stress, inflammation, and apoptosis and protects rats against diabetic nephropathy by Al Hroob AM1, Abukhalil MH2, Alghonmeen RD3, Mahmoud AM4. (PubMed)
(4) Olive oil in the treatment of hypercholesterolemia by Cullinen K. (PubMed)
#Fennel's #Anethole Modulates the Chemo-Activity Against the Onset of Cancer, Researchers Say
Kyle J. Norton
Fennel may have a potential and positive effect in modulating the effect of chemo drugs through its chemomodulatory activity, some scientists suggested.
The expression of fennel application in enhanced chemopreventive response was evident in animal models from the reduced tumor burden in reduced cancer cell proliferation and apoptosis and reduced percentage of tumors through some different publications.
The results were reported by several respectable institutes including Jawaharlal Nehru University and published in online medical literature.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
According to the Jawaharlal Nehru University, in evaluating the chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds on DMBA-induced skin and B(a)P-induced forestomach papilloma genesis in Swiss albino mice, application of fennel seeds displayed a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group.
Biochemical assays showed a significant increase in the content/activities of phase I and II enzymes especially in the case of a 6% test diet, in detoxifying poisonous compounds caused by the injection of DMBA, through significant enhancement of antioxidant activities.
Further examination also found that injection of fennel seed stimulated the production of antioxidant enzymes in the body tissue in repaired damage precipitated by peroxidation through lactate dehydrogenase activity.
Dr. Singh B, the lead author said, "A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6%" and "glyoxalase I(with function as an enzymatic defense against glycation) activity and the content of reduced glutathione (antioxidant) were significantly elevated".
Additionally, in the examination of the effect of fennel bioactive compound anethole in chemo modulatory activity against the onset and spread of cancer, researchers found that the application of fennel oil by inhibited the activated expression of NF-kappa B, a gene-altering and inflammation in triggering molecule in the development of various solid tumors through stimulated cancer proliferation.
Also, anethole injection reduced levels of tumor necrosis factor (TNF, tumor necrosis factor-alpha, TNFα, cachexin, or cachectin), a cell-signaling protein (cytokine) involved in systemic inflammation and one of the cytokines that make up the acute phase reaction. However, at a certain stage of cancer, gene expression in promoted cancer apoptosis is alternated, and TNF changes from a cancer killer to a cancer promoter.
Additionally, with abundant fiber, fennel demonstrated a strong effect in the removal of toxins from the colon and therefore may be helpful in colon cancer prevention.
Dr. After taking into account other co and confounders said, " Fennel contains flavonoid anti-oxidants compounds like kaempferol and quercetin which helps eliminate harmful free radicals from the body....".
In other words, fennel exerted chemo modulatory activity also through its flavonoid anti-oxidant compounds like kaempferol and quercetin in inhibited overexpression of free radicals and free radical chain reactive in protected against cytotoxicity in induction cells damage and alternated cell DNA in the facilitated onset of cancer.
Taking together, fennel and its bioactive compound may be considered a chemopreventive and modulatory functional food for reduced risk and treatment of various types of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system by Singh B1, Kale RK(PubMed)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Arzoo and Milind Parle, Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology(EUROPEAN JOURNAL OF PHARMACEUTICALAND MEDICAL RESEARCH)
Fennel may have a potential and positive effect in modulating the effect of chemo drugs through its chemomodulatory activity, some scientists suggested.
The expression of fennel application in enhanced chemopreventive response was evident in animal models from the reduced tumor burden in reduced cancer cell proliferation and apoptosis and reduced percentage of tumors through some different publications.
The results were reported by several respectable institutes including Jawaharlal Nehru University and published in online medical literature.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
According to the Jawaharlal Nehru University, in evaluating the chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds on DMBA-induced skin and B(a)P-induced forestomach papilloma genesis in Swiss albino mice, application of fennel seeds displayed a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group.
Biochemical assays showed a significant increase in the content/activities of phase I and II enzymes especially in the case of a 6% test diet, in detoxifying poisonous compounds caused by the injection of DMBA, through significant enhancement of antioxidant activities.
Further examination also found that injection of fennel seed stimulated the production of antioxidant enzymes in the body tissue in repaired damage precipitated by peroxidation through lactate dehydrogenase activity.
Dr. Singh B, the lead author said, "A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6%" and "glyoxalase I(with function as an enzymatic defense against glycation) activity and the content of reduced glutathione (antioxidant) were significantly elevated".
Additionally, in the examination of the effect of fennel bioactive compound anethole in chemo modulatory activity against the onset and spread of cancer, researchers found that the application of fennel oil by inhibited the activated expression of NF-kappa B, a gene-altering and inflammation in triggering molecule in the development of various solid tumors through stimulated cancer proliferation.
Also, anethole injection reduced levels of tumor necrosis factor (TNF, tumor necrosis factor-alpha, TNFα, cachexin, or cachectin), a cell-signaling protein (cytokine) involved in systemic inflammation and one of the cytokines that make up the acute phase reaction. However, at a certain stage of cancer, gene expression in promoted cancer apoptosis is alternated, and TNF changes from a cancer killer to a cancer promoter.
Additionally, with abundant fiber, fennel demonstrated a strong effect in the removal of toxins from the colon and therefore may be helpful in colon cancer prevention.
Dr. After taking into account other co and confounders said, " Fennel contains flavonoid anti-oxidants compounds like kaempferol and quercetin which helps eliminate harmful free radicals from the body....".
In other words, fennel exerted chemo modulatory activity also through its flavonoid anti-oxidant compounds like kaempferol and quercetin in inhibited overexpression of free radicals and free radical chain reactive in protected against cytotoxicity in induction cells damage and alternated cell DNA in the facilitated onset of cancer.
Taking together, fennel and its bioactive compound may be considered a chemopreventive and modulatory functional food for reduced risk and treatment of various types of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system by Singh B1, Kale RK(PubMed)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Arzoo and Milind Parle, Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology(EUROPEAN JOURNAL OF PHARMACEUTICALAND MEDICAL RESEARCH)
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