#Ginger Exerts Free Radical Scavenging Activities through All Members of the Antioxidant Family, Scientists Show

Kyle J. Norton

Ginger may have a potential effect in reducing oxidative stress by inhibiting the overexpression of free radicals as scavengers, some studies suggested.

A free radical is an unstable molecule with an unpaired electron in the outer ring of the atom. In order for them to become stable, free radicals are actively donated or steal an electron from the stable molecules.

Once started, the chain of domino effect cannot be stopped until the outer ring of the electron is paired or inhibited by the antioxidant.

Free radical scavengers are antioxidants that inhibit oxidation.

There are 2 types of antioxidants in the body including the antioxidant enzymes produced by the host and dietary sources of antioxidant intake by the host.

Oxidative stress is the expression of the imbalance of the levels of free radicals and antioxidants in the body.

In other words, oxidative stress can either be caused by overexpression of free radicals or low levels of antioxidant enzymes.

A prolonged period of oxidative stress can damage the body tissue, and alter the immune function and cell DNA, leading to the etiology of many chronic health problems including cardiovascular and inflammatory disease, and cancer.

There are many causes of overexpression of free radicals, some researchers suggested that fried foods, alcohol, tobacco smoke, pesticides, air pollutants, and many more are contributed to the onset of the condition.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In finding the chemical constituents that constitute the free radical scavenger activity of ginger, a research team at the University of Mysore analyzed the chemical composition and antioxidant activity (in aqueous and solvent extracts) of Ginger root (Zingiber officinale).

During the experiment, application of ethanol, methanol, acetone, 80% methanol, and 80% ethanolic extracts to determine free radical scavenging activity, suggesting that the order of antioxidant activity by reducing power and free radical scavenging activity by DPPH was 80% methanolic > 80%ethanolic > methanolic > ethanolic > 30°C water >100°C water > acetonic extract.

These results suggested that ginger's efficacy in the inhibition of free radicals was not attributed to a single ingredient but to all members of the antioxidant family.

In the investigation of the free radical scavenger activity of 4 essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger), researchers found
* All prepared ginger essential oils, showed a significant free radical scavenger property

* Essential oil from the seed and air-dried rhizomes demonstrated the highest anti-free radical activity compared to other preparations.

* Essential oil from the seed and air-dried rhizomes also are the better free radical scavenger agents, compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.

* [6]-shogaol, the bioactive compound isolated from the ginger was most active against filament formation and growth of C. Albicans, followed by citral and [6]-gingerol.

An additional examination also indicated that ginger oleoresin, especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radicals in comparison to essential oils of ginger and other Zingiberaceae plants.

In support of the above differentiation, researchers at the North China Coal Medical College, in the report "[Scavenging effects of ginger on superoxide anion and hydroxyl radical]" wrote,
"Ginger can significantly scavenge O2-. in hypoxanthine-xanthine oxidase system and. OH in ultraviolet exposure of H2O2 system". and "The scavenging effects of ginger on O2-. and. OH may contribute to explaining some of the pharmacological mechanisms of this drug".

Taken altogether, ginger with the abundant bioactive compound may be considered a free radical scavenger functional food for preventing overexpression of free radicals in the initiation of a chain reaction


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) [Scavenging effects of ginger on superoxide anion and hydroxyl radical].[Article in Chinese] by Cao ZF1, Chen ZG, Guo P, Zhang SM, Lian LX, Luo L, Hu WM. (PubMed)
(3) Chemical composition and antioxidant properties of ginger root (Zingiber officinale) (Research Gate)

Only Certain Varieties of #Onion Process Antithrombotic and Thrombolytic Activity., Researchers Say

Kyle J. Norton

Antithrombotic activity is an action that reduces the formation of blood clots.

Antithrombotics are the medicines that are used therapeutically for the prevention or treatment of dangerous coagulation, particularly in acute thrombus.

Conventionally, medications that treat blood clots can be classified into anticoagulants and antiplatelet drugs
* Anticoagulants; The main function of anticoagulation is to slow down clotting by reducing fibrin formation. However, they are also used to prevent clots from forming and growing.

* Antiplatelet agents; The main function of antiplatelet agents is to prevent platelets from clumping together. However, they also exert a similar effect to those of anticoagulation.

Thrombolytic activity is an action that dissolves dangerous clots in blood vessels and improves blood flow, with an aim to prevent damage to tissues associated with heart diseases and stroke.

Thrombolysis, also known as thrombolytic therapy, is a type of conventional medicine that performs thrombolytic activity.


The most common agents of thrombolytic therapy are Eminase (anistreplase), Retavase (reteplase), and Striptease (streptokinase, kabikinase).


There are many factors associated with the risk of blood clots including bone fractures, major surgery, use of birth control pills, and pregnancy.


Epidemiologically, obesity, cigarette smoking, cancer, chemotherapy, and personal history of abnormal blood clotting are also the prevalent factors found in patients with thrombus.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

In finding a potential compound that promotes blood thinning, researchers examined the properties of onion extracts' antithrombotic effect.

According to the results of the experiment* Toyohira, one of the onion varieties showed significant antithrombotic activity both in vitro and in vivo.

* Moreover, Toyohira not only exhibited thrombolytic activity but also promoted the antiplatelet effect.

* Superkitamomiji, 2935A, and K83211, other varieties of onion showed only thrombolytic activity.

* More interestingly, quercetin, the richest flavonoid in onion, showed no correlation in the antithrombotic activity.
Based on the results, researchers strongly suggested that onion A. cepa can be classified into varieties with or without antithrombotic and thrombolytic effects.

In other words, only certain varieties of onion process antithrombotic and thrombolytic activity.

Taken together, certain onion varieties may be as antithrombotic and thrombolytic agents, pending the confirmation of the larger sample size and multicenter human study.


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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) An onion variety has natural antithrombotic effect as assessed by thrombosis/thrombolysis models in rodents by Yamada K1, Naemura A, Sawashita N, Noguchi Y, Yamamoto J. (PubMed)

#Fennel' Trans-Anethole Process Inhibiting Pro-Inflammatory Mediators Property, According to Studies

Kyle J. Norton

Scientists may have found food and plant processes the antipyretic activity comparable to those of acetaminophen in patients with fever, some studies suggested.
Fever is a natural reaction caused by the production of pro-inflammatory cytokines in the immune system to protect our body from damage and injury against foreign pathogens during the acute phase of infection.

According to medical literature, a person is not considered to have a significant fever until the temperature is above 100.4 F (38.0 C).

Although fever is a common syndrome, however, if you or your kid are experiencing fever accompanied by symptoms of a severe headache, unusual skin rash, sensitivity to bright light, persistent stiff neck and pain, mental confusion, particularly persistent vomiting, and difficulty breathing or chest pain, you or your kid should go to the hospital right the way.

Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The plant and food have been used in traditional and herbal medicine as warming, carminative, antispasmodic, and antidepression agents and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...

In the study to evaluate the antipyretic effect of the aqueous extract of the herbal coded formulation containing an equal amount of Salix alba, Emblica officinalis, Glycyrrhiza glabra, Adhatoda vasica, Viola odorata, in a yeast-induced pyrexia model in rabbits, researchers found that after recording the results immediately before the administration of the extractor paracetamol and again at 1 hour, application of the extract at 240mg/kg dose significant reduces elevated temperature as compared with that of standard drug paracetamol (150mg/kg).

Fennel extract applied alone showed antipyretic activity against hyperpyrexia in mice, induced by S.C. administration of 2 mL/100 g of a 20% aqueous suspension of brewer's yeast.

As an antipyretic agent, ethanolic extract of F. vulgare fruit showed a moderate antipyretic activity that was statistically significant after 30 and 90 min.

These results showed that herbal coded medicine at a dose of 240mg/kg and fennel extract have marked an antipyretic activity in animal models and this was strongly supported by the ethnopharmacological uses of medicinal plants.

Furthermore, in the examine the hepatotoxicity induced by acetaminophen caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI) in the induction of symptoms such as fever due to inflammation, researchers showed that application of trans-anethole, an aromatic compound isolated from fennel exerted a significant effect in the inhibited pro-inflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitric oxide (NO)thus decreasing the risk of fever caused by an overreaction of the immune system.

Application of AN at doses 125 and 250mg/kg once a day for seven days prevented the changes caused by the APAP overdose.

Additionally, researchers also discovered, that AN infection prevents the overexpression of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α, and MCP-1 and induces the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10), thus reducing the onset of fever.

Taken together, there is no doubt that fennel may be considered a functional food for the treatment of inflammatory-induced fever.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Antipyretic potential of herbal coded formulation (Pyrexol) by Khan MS1, Hamid A2, Akram M3, Mustafa SB3, Sami A1, Shah SMA4, Usmanghani K(PubMed)
(3) Acetaminophen-induced hepatotoxicity: Preventive effect of trans-anethole by da Rocha BA1, Ritter AM2, Ames FQ3, Gonçalves OH4, Leimann FV5, Bracht L6, Natali MR7, Cuman RK8, Bersani-Amado CA(PubMed)

#Phytochemical #Betacyanin and #Detanidin Process Strong Free Radical Scavenging Activities, Researchers Say

Kyle J. Norton

Antioxidants are stable molecules produced by the liver or from the intake of diet sources, including foods and supplementation.
The function of antioxidants is to protect the body against oxidation induced by free radicals.

Free radicals are a normal byproduct of oxygen metabolism. Certain environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.

Free radicals have an unpaired electron on the outer ring. Therefore, in order to maintain stability, free radicals must donate or intercept an electron from other atoms, causing the domino reaction that can not be stopped until all single electrons are paired or inhibited by antioxidants.

Oxidative stress is a result of the imbalanced ratio of the levels of free radicals compared to antioxidants.

In other words, if the antioxidant enzymes no longer can perform the function of balancing the free radicals in the body, oxidative stress occurs.

Epidemiologically, oxidative stress has been found to cause protein, lipid, and alternation of cellular DNA, leading to the incidence of chronic illness and cancers.


Dr. V. Hajhashemi, the lead scientist in the elevation of the effects of antioxidants for disease prevention wrote, "Free radicals are produced continuously in the cells as part of normal cellular function, however, excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity".

And, " Many basic research studies and observational epidemiologic studies in humans suggest that antioxidants can prevent oxidative damage".


In other words, by maintaining a healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.

Some researchers suggested, that maintaining a balanced ratio of free radicals and antioxidants is the best way for good health.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the treatment of oxidative stress, researchers examined the betacyanins phenol antioxidants activity against peroxyl radicals generated from the azo-initiated oxidation of methyl linoleate in methanol and of a heterogeneous aqueous/soybean phosphatidylcholine liposomal system

In the major compound betanin, researchers found that the phytochemical, a weak retarder in methanol is an effective chain-breaking antioxidant in the liposomal model.

In other words, kinetic solvent activity and partition in lipid bilayers may affect betanin antioxidant properties.


Betanidin, another bioactive compound shows a significant effect on chain-terminating antioxidants in both models.

In ROS activity, betanidin demonstrated a stronger radical-scavenging activity compared to betanin, in terms of both radical-scavenging rates constant and stoichiometric factor.


The results suggest that betacyanins exert significant anti-ROS expression by blocking the initiation and progression and induce-termination of a free radical chain reaction through the bioactive compound betanin and betanidin.

Based on the findings, researchers said, " Either betanin or betanidin incorporated in liposomes with alpha-tocopherol had additive effects, supporting the partition of the pigments in the bilayer and lipoperoxyl radical reduction".


Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Effect of solvent type and ratio on betacyanins and antioxidant activity of extracts from Hylocereus polyrhizus flesh and peel by supercritical fluid extraction and solvent extraction by Fathordoobady F1, Mirhosseini H1, Selamat J2, Manap MY. (PubMed)
(3) Are antioxidants helpful for disease prevention? by V. Hajhashemi,1,* G. Vaseghi,1 M. Pourfarzam,2 and A. Abdollahi. (PMC)

3,3'-Diindolylmethane Inhibits protein RANKL Associated with the Onset of #Arthritis, Researchers Reveal

Kyle J. Norton

Arthritis is a group of diseases associated with the inflammation of the joints. According to epidemiological studies osteoarthritis (OA) and rheumatoid arthritis (RA) are the 2 most common types of arthritis.
According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults which is diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.

Depending on type and the location affected, arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.

* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

* Polymyalgia arthritis is a condition of inflammatory rheumatic disease-induced pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.

* Fibromyalgia in The newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result of responding to pressure.

As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve the quality of life for patients to carry out daily activities.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.

The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.

According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.

Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.

Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.


The receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved in the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.

Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)

#Herbal #Turmeric Inhibits Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells through Cell Death Programming, Researchers Suggest

Kyle J. Norton

Cancer is a group of chronic diseases associated with cell growth disorderly in the tissue of some specific organ. Depending on the grade and stage, most cases of cancer in the advanced stage have been found to induce a higher mortality rate compared to cancer diagnosed in the localized stage.
Head and neck cancer is a group of cancers that starts in the cell on the surface of the inner lining of the mouth, nose, throat, larynx, sinuses, or salivary glands.

Squamous cell carcinoma is cancer arising from the squamous cells found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities.

Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.

Head and neck squamous cell carcinoma (HNSCC) epidemiologically has been found to spread to the lymph nodes or lungs. More than 90% of the head and neck cancers diagnosed are squamous carcinomas.

Symptoms of head and neck cancer may include a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in voice.

According to the statistics provided by the Western General Hospital, squamous cell cancer of the head and neck is common worldwide accounting for 4% of all cancers in the United States and 5% in the United Kingdom.

The exact causes of head and neck squamous cell carcinoma (HNSCC) are unknown. However, geographically, smoking tobacco, drinking alcohol, and long-term poor diet are important to risk factors in the West compared to risk factors of chewing betel or areca nuts, smoking bidis, and taking snuff are important in the Indian subcontinent.

More importantly, the genetic preposition of genome 9p21, which may indicate the loss of a gene that suppresses tumors accounted for a total of 70% of all cases.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of head and neck cancer, researchers examined the effect of curcumin on head and neck squamous cell carcinoma (HNSCC) using a panel of cell lines with and without human papillomavirus (HPV+, HPV-).


According to the tested differentiation, curcumin treatment of HNSCC cell lines not only interfered with RNA of Skp2, which causes cancer tumorigenesis and radiation tolerance but also induced concomitant accumulation of p21 and p27 associated with a cell cycle arrest in HPV+, HPV- cells.

Furthermore, curcumin inhibits cell viability and induces apoptosis in a dose-dependent manner in the tested cell line with and without human papillomavirus (HPV+, HPV-).

Moreover, curcumin treatment of HPV+ and HPV- cells resulted in apoptosis via the mitochondrial pathway of apoptosis and activation of caspases that play a critical role in programmed cell death.

Additionally, the inhibition of HPV+ and HPV- cells by curcumin was also found to suppress the expression of poor prognostic markers such as XIAP, and cancer survival such as cIAP1, and cIAP2.

More importantly, co-treatment of HNSCC cells with curcumin and cisplatin potentiated inhibition of cell viability and apoptotic effects.

Based on the findings, researchers wrote in the final report, "These data suggest an important function for curcumin, acting as a suppressor of oncoprotein Skp2 in squamous cell carcinoma cells in both HPV+ and HPV- cells".

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of HNSCC, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells by Khan AQ1, Siveen KS1, Prabhu KS1, Kuttikrishnan S1, Akhtar S1, Shaar A1, Raza A2, Mraiche F3, Dermime S2, Uddin S. (PubMed)
(2) TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma by Piao L1,2, Mukherjee S3,4, Chang Q4,5, Xie X1,2, Li H6, Castellanos MR7, Banerjee P3,4, Iqbal H1,2, Ivancic R1,2, Wang X1,2, Teknos TN1,2, Pan Q. (PubMed)
(3) Squamous cell carcinomas of the head and neck by R J Sanderson, consultant otolaryngologist and J A D Ironside, consultant clinical oncologist. (PMC)

#Healthyfood #Tomatoes Protect the Tissues of Stomach Against Gastric Injury-Induced by Excessive Alcohol Consumption

Kyle J. Norton

Gastrointestinal injury is an injury associated with the stomach, small bowel, colon, or rectum.
In other words, any damage to the organs of the digestive system caused by blunt or penetrating trauma is considered a gastrointestinal injury.

Gastrointestinal injury caused by blunt trauma in children is uncommon, accounting for less than 1% of all gastrointestinal injuries.

Believe it or not, in children, the most common causes of gastrointestinal injury are caused by a discrete point of energy transfer such as a seatbelt (19%), a handlebar (13%), or a blow from abuse (19%), or other blows and is unique to this population, according to the Children's Hospital.


Depending on the organ damage, patients may experience different symptoms.

In small intestinal injury, patients may have symptoms of pain close to the injured bowel segment, abdominal distension, and diarrhea, ileus, diffuse abdominal pain, nausea, and vomiting.

In large intestinal injuries, patients may have symptoms of persistent focal pain in a trocar site with abdominal distention, diarrhea, and leukopenia.

In gastric/stomach injury, patients May first experience symptoms of nausea, vomiting, blood in the urine, and fever, followed by abdominal pain, tenderness, distension, or rigidity.

In rectal injury, patients may have symptoms of rectal itching, pain, and rectal bleeding.


Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In finding a potential ingredient for the prevention and treatment of gastrointestinal injury, researchers investigated the transgenic mini-tomato and protection against alcohol-induced gastrointestinal injury.

By examining the function of the epidermal growth factor (EGF) in maintaining the physiological function of the mucosa of the digestive tract, and promoting the healing of the gastric and duodenal ulcers, researchers chemically synthesized a tomato codon preference hEGF gene by Agrobacterium-mediated transformation.

Epidermal growth factor (EGF) has been found to play an essential role in wound healing by stimulating epidermal and dermal regeneration.

According to the radioimmunoassay (RIA),15 days of intragastric gavage (ig) administration of the rhEGF-containing juice of the transgenic tomato could significantly protect mice against alcohol-induced ulceration.

The Ulcer index expressed as a degree of the stomach lesion, also decreased from 42.20 +/- 18.13 to 16.25 +/- 9.57.

In other words, the transgenic tomato protects the integrity of the stomach cell against the insults of excessive alcohol consumption that damage the stomach lining tissues and speeds up ulcer healing

Taken together, tomatoes with rhEGF may be considered a dietary supplement for the prevention and treatment of gastrointestinal injury, pending a large sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Transgenic mini-tomato and protection against alcohol-induced gastric injury by Zhi Q1, Wang S, Chai M, Zhang F, Li Q, Li S, Sun M. (PubMed)
(2) Injuries of the gastrointestinal tract from blunt trauma in children: a 12-year experience at a designated pediatric trauma center by Canty TG Sr1, Canty TG Jr, Brown C. (PubMed)