Kyle J. Norton
Age-related neurological disorders or neurodegenerative diseases are the conditions of the progressive death of neurons due to aging, leading to problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Dementia is a general term of a neurodegenerative disease that causes a decline in memory and thinking skills severe enough to reduce a person's ability to perform everyday activities and quality of life.
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
The most common types of dementia are
* Alzheimer's disease
Alzheimer's destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of degeneration of the hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.
* Absence of acetylcholine
The absence of acetylcholine is a condition caused by damage of nerves located in front of the brain, which lead to language difficulty, memory loss, concentration problem, and reduced mobile skills due to a lack of reaction in muscular activity and refection and anxiety- and depression-like behaviors.
3. Dementia due to long-term alcohol abuse
A most classic form of the condition is Korsakoff's dementia results in extremely poor short-term memory often associated with the memory loss of confabulations due to diminished processing resources and/or an encoding or retrieval deficit.
* Dementia associated with Parkinson's disease
Parkinson's disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
Besides aging, geographical, hereditary viral, and toxicological exposure may also correlate to the development of diseases in the elderly.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of continued finding a natural ingredient for the treatment of age-related neurological disorders (ANDs), researchers examined the effects of ginger used in traditional medicine for the treatment of various disease symptoms.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of neurodegenerative diseases, researchers examined the effect of purified cranberry proanthocyanidins (PAC-1A) on neuroblastoma (NB) cell lines.
On SMS-KCNR cells, PAC-1A caused a loss of proton motive force associated with the increase of generation of reactive oxygen species (ROS) that induce cytotoxicity in the tested cell line.
Furthermore, PAC-1A 6-gingerol inhibits neuroblastoma (NB) cell lines by reducing the expression of the proteins associated with pro-survivals (Bcl-2, MCL-1, Bcl-xL) and increased levels of proteins associated with pro-apoptosis (Bax, Bad, Bid).
Moreover, pathways involved in apoptosis were also increased by the injection of PAC-1A compared to the inhibition of the expression of pathways involved in the promotion of cell cycle division.
More importantly, cyclophosphamide (CP), the chemo drug used to suppress the immune system function also exhibited by the injection of PAC-1A.
In other words, PAC-1A and CP worked synergistically to increase cytotoxicity and expression of pro-apoptotic markers, and reduce cellular antioxidants enzymes (glutathione (GSH) and superoxide dismutase (SOD)) levels.
In an additional analysis of the anti-cancer activity of PAC-1A, researchers found that Additional features of PAC-1A also slow down the cancer cell cycle progression and induce cell death via TNF-family death receptor activity.
Based on the findings, researchers said, "PAC-1A has demonstrated the chemotherapeutic potential to treat a broad spectrum of NBs including highly malignant tumors that show resistance to standard chemotherapeutics and apoptotic stimuli".
Taken together, cranberry may be considered a remedy for the prevention and treatment of neurodegenerative disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Purified cranberry proanthocyanidines (PAC-1A) cause pro-apoptotic signaling, ROS generation, cyclophosphamide retention and cytotoxicity in high-risk neuroblastoma cells by Singh AP1, Lange TS, Kim KK, Brard L, Horan T, Moore RG, Vorsa N, Singh RK. (PubMed)
(1) Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vacciniummyrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin by Cásedas G1, González-Burgos E2, Smith C3, López V4, Gómez-Serranillos MP. (PubMed)
(2) Most common diseases of 50 plus - Diseases of Central Nervous system - Dementia: The Types by Kyle J. Norton
Wednesday, 30 August 2023
6-Gingerol Isolated #Ginger Exerts Liver Protective Activity, According to Studies
Kyle J. Norton
The functions of the liver are to filter out blood coming from the digestive tract, before passing it to the rest of the body.
In other words, the liver inhibits chemical toxins and other harmful by-products such as medication before distributing the clean blood to nourish the body.
In detail, the liver also plays a critical role in bile production for the digestive system in breaking down food, and excretion of bilirubin to clear waste products, production of cholesterol for building the cell wall membrane, and vitamin D secretion as well as steroormones.
According to the statistics, provided by the World Health Organization, liver diseases affect the largest population worldwide, representing 46% of global diseases.
Out of 35 million people in the world who die of chronic diseases, 59% are liver diseases and 59% of the mortality is because of chronic diseases.
Jaundice, persistent abdominal pain and swelling, swelling in the legs and ankles, chronic fatigue and gastrointestinal discomforts, particularly persistent itchy skin, dark urine color, and pale stool are some common signs and symptoms of liver problems.
Although there are many risk factors associated with the onset of liver diseases, excessive alcohol drinking may be the major cause of liver diseases in the Western world, besides hepatitis C infection.
Dr. Radan Bruha, in the evaluation of alcoholic liver diseases, wrote, "Alcohol consumption is directly associated with liver disease mortality and accounts for elevated social and economic costs. Alcoholic liver disease (ALD) may take the form of acute involvement (alcoholic hepatitis) or chronic liver disease (steatosis, steatohepatitis, fibrosis, and cirrhosis)".
And, " The severity and prognosis of the alcohol-induced liver disease depend on the amount, pattern and duration of alcohol consumption, as well as on the presence of liver inflammation, diet, nutritional status and genetic predisposition of an individual. While steatosis is an almost completely benign disease, liver cirrhosis is associated with marked morbidity, mortality, and life expectancy shortening. The median survival of patients with advanced cirrhosis is 1-2 years. Severe acute alcoholic hepatitis (AH) is associated with mortality as high as 50%".
The results strongly suggested that excessive alcohol drinking over time will definitely cause alcoholic liver disease.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Scientists on finding a natural remedy for improving liver functioning examined the effects of 6-gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats.
36 female Wistar rats included in the study were divided into 4 groups: control, received a normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6-gingerol (200 μg/kg and 400 μg/kg) for 14 days.
Before application of 6-gingerol, the group administrated by EV showed an increase in body and ovarian weights, abnormality in serum sex steroid profile and proinflammatory cytokines, and a decrease of antioxidant activity associated with the increase of total cholesterol (TC), low-density cholesterol (LDL-C), triglycerides.
However, pretreatment 6-gingerol treatments, particularly the 400 μg/kg dose, restored the alteration back to normal and improved liver in the regulation of lipid profile.
The findings suggested that 6-gingerol processed beneficial effects in PCOS rats by inhibiting oxidative stress and restoring biochemical parameters to normal decreasing the cysts in the ovaries and increasing liver functioning.
In order to reveal more information on the ginger effect on the liver, researchers also reviewed the liver protective activity of polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary, and ginger) from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage.
Injection of polyphenols showed a strong effect in binding ions of Cd against Cd in the induction of hepatotoxicity.
Although most studies are conducted in animal models, some of them are derived from experimental models that reflect human exposure. Therefore it is safe to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans, including ginger.
Taken altogether, ginger used alone or combined with other polyphenol-rich foods may be considered functional remedies for improving liver functioning with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effects of 6-Gingerol on reproductive improvement, liver functioning, and Cyclooxygenase-2 gene expression in estradiol valerate - Induced polycystic ovary syndrome in Wistar rats by Pournaderi PS1, Yaghmaei P2, Khodaei H3, Noormohammadi Z1, Hejazi SH4. (PubMed)
(2) Review of polyphenol-rich products as potential protective and therapeutic factors against cadmium hepatotoxicity by Mężyńska M1, Brzóska MM1. (PubMed)
(3) Alcoholic liver disease by Radan Bruha, Karel Dvorak, and Jaromir Petrtyl. (PMC)
The functions of the liver are to filter out blood coming from the digestive tract, before passing it to the rest of the body.
In other words, the liver inhibits chemical toxins and other harmful by-products such as medication before distributing the clean blood to nourish the body.
In detail, the liver also plays a critical role in bile production for the digestive system in breaking down food, and excretion of bilirubin to clear waste products, production of cholesterol for building the cell wall membrane, and vitamin D secretion as well as steroormones.
According to the statistics, provided by the World Health Organization, liver diseases affect the largest population worldwide, representing 46% of global diseases.
Out of 35 million people in the world who die of chronic diseases, 59% are liver diseases and 59% of the mortality is because of chronic diseases.
Jaundice, persistent abdominal pain and swelling, swelling in the legs and ankles, chronic fatigue and gastrointestinal discomforts, particularly persistent itchy skin, dark urine color, and pale stool are some common signs and symptoms of liver problems.
Although there are many risk factors associated with the onset of liver diseases, excessive alcohol drinking may be the major cause of liver diseases in the Western world, besides hepatitis C infection.
Dr. Radan Bruha, in the evaluation of alcoholic liver diseases, wrote, "Alcohol consumption is directly associated with liver disease mortality and accounts for elevated social and economic costs. Alcoholic liver disease (ALD) may take the form of acute involvement (alcoholic hepatitis) or chronic liver disease (steatosis, steatohepatitis, fibrosis, and cirrhosis)".
And, " The severity and prognosis of the alcohol-induced liver disease depend on the amount, pattern and duration of alcohol consumption, as well as on the presence of liver inflammation, diet, nutritional status and genetic predisposition of an individual. While steatosis is an almost completely benign disease, liver cirrhosis is associated with marked morbidity, mortality, and life expectancy shortening. The median survival of patients with advanced cirrhosis is 1-2 years. Severe acute alcoholic hepatitis (AH) is associated with mortality as high as 50%".
The results strongly suggested that excessive alcohol drinking over time will definitely cause alcoholic liver disease.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Scientists on finding a natural remedy for improving liver functioning examined the effects of 6-gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats.
36 female Wistar rats included in the study were divided into 4 groups: control, received a normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6-gingerol (200 μg/kg and 400 μg/kg) for 14 days.
Before application of 6-gingerol, the group administrated by EV showed an increase in body and ovarian weights, abnormality in serum sex steroid profile and proinflammatory cytokines, and a decrease of antioxidant activity associated with the increase of total cholesterol (TC), low-density cholesterol (LDL-C), triglycerides.
However, pretreatment 6-gingerol treatments, particularly the 400 μg/kg dose, restored the alteration back to normal and improved liver in the regulation of lipid profile.
The findings suggested that 6-gingerol processed beneficial effects in PCOS rats by inhibiting oxidative stress and restoring biochemical parameters to normal decreasing the cysts in the ovaries and increasing liver functioning.
In order to reveal more information on the ginger effect on the liver, researchers also reviewed the liver protective activity of polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary, and ginger) from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage.
Injection of polyphenols showed a strong effect in binding ions of Cd against Cd in the induction of hepatotoxicity.
Although most studies are conducted in animal models, some of them are derived from experimental models that reflect human exposure. Therefore it is safe to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans, including ginger.
Taken altogether, ginger used alone or combined with other polyphenol-rich foods may be considered functional remedies for improving liver functioning with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effects of 6-Gingerol on reproductive improvement, liver functioning, and Cyclooxygenase-2 gene expression in estradiol valerate - Induced polycystic ovary syndrome in Wistar rats by Pournaderi PS1, Yaghmaei P2, Khodaei H3, Noormohammadi Z1, Hejazi SH4. (PubMed)
(2) Review of polyphenol-rich products as potential protective and therapeutic factors against cadmium hepatotoxicity by Mężyńska M1, Brzóska MM1. (PubMed)
(3) Alcoholic liver disease by Radan Bruha, Karel Dvorak, and Jaromir Petrtyl. (PMC)
#Healthyfood Tomato's Lycopene Inhibits #ProstateCancer by Decreasing PSA Levels, Studies Show
Kyle J. Norton
Prostate cancer is a medical condition caused by irregular cell growth in the tissues of the prostate.
The prostate is a male reproductive gland that plays a critical role in the contribution of nutrients and fluid to sperm.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper prostate gland layers to induce metastasis via blood and lymph.
At the early stage, due to the very small size of the tumor, prostate cancer is asymptomatic.
The most common symptoms of the prostate at the later stage are frequent urination and weak or interrupted urine flow due to the tumor that affects the tube surrounded by the prostate.
In some cases, patients may experience symptoms of blood in the urine and pain due to the oversized tumor that has pressed on the nearby blood vessels and nerve cells.
The new onset of erectile dysfunction is also common in patients with prostate cancer.
The causes of prostate cancer are not identified. However, the increase in aging is one of the most common risk factors as most cases of the condition are diagnosed in older adults. Approximately, 60% of all cases are diagnosed in men over 65.c
According to the statistics, in 2017, 21,300 men were diagnosed with prostate cancer, and the disease caused the death of 4,100 men in the same year.
The 5-year survival rate for most men with local or regional prostate cancer is nearly 100% compared to only 30% in patients diagnosed with prostate cancer that has spread to other parts of the body,
Some researchers concerned that the risk of prostate cancer in the younger population suggested that the promotion of a high-fat diet over the past few decades may be correlated to the rise of the disease.
Dr. Colleen Pelser, the lead scientist wrote, "Total fat and mono- and polyunsaturated fat INTAKES were not associated with the incidence of prostate cancer. Saturated fat intake was related to increased risk of advanced prostate cancer (HRQuintile 5 vs. Quintile 1 (Q1 vs. Q5)1.21; 95% CI 1.00–1.46; p-for-trend=0.03) and fatal prostate cancer".
And. "Our study suggests that the associations of fat and fatty acids differ by prostate cancer severity. Saturated fat, ALA, and EPA intakes were related to the risk of advanced or fatal prostate cancer, but not to non-advanced prostate cancer".
The results strongly suggested that if you are a high-fat diet follower, your risk of prostate cancer is increased substantially compared to a traditional diet.
Tomato is a red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural compound for the treatment of prostate cancer, researchers investigated the effects of lycopene-rich tomato on prostate-specific antigen (PSA) in prostate cancer patients.
The study included 79 patients with prostate cancer randomized to a nutritional intervention with either 1) tomato products containing 30 mg lycopene per day; 2) tomato products plus selenium, omega-3 fatty acids, soy isoflavones, grape/pomegranate juice, and green/black tea (tomato-plus); or 3) control diet for 3 weeks.
According to the results of the test, the tomato group showed a significant PSA decrease compared to controls.
Compared to other groups, median PSA values decreased by 1% in patients with the highest increases in plasma lycopene, selenium, and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium, and C20:5 n-3 fatty acid.
In other words, PSA decreased the most in patients with the highest increase in lycopene alone.
Based on the findings, researchers said, "Three-week nutritional interventions with tomato products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer".
Moreover, in the investigation of the association between tomato consumption and prostate cancer risk, researchers at Zhejiang University performed a meta-analysis to comprehensively evaluate this relationship.
Geographically, tomato intake showed significant protective effects in patients of Asian origin and Oceania populations compared to other regions.
According to the total of 24 published studies with 15,099 cases, tomato intake was associated with a reduced risk of prostate cancer with RRs of 0.76 found in the case-control and cohort studies.
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA by Paur I1, Lilleby W2, Bøhn SK3, Hulander E4, Klein W5, Vlatkovic L6, Axcrona K7, Bolstad N8, Bjøro T9, Laake P10, Taskén KA11, Svindland A12, Eri LM13, Brennhovd B14, Carlsen MH15, Fosså SD16, Smeland SS17, Karlsen AS18, Blomhoff R. (PubMed)
(2) Tomato consumption and prostate cancer risk: a systematic review and meta-analysis by Xu X1, Li J1, Wang X1, Wang S1, Meng S1, Zhu Y1, Liang Z1, Zheng X1, Xie L. (PubMed)
(3). Dietary Fat, Fatty Acids and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study
Colleen Pelser,1 Alison M. Mondul,2 Albert R. Hollenbeck,3 and Yikyung Park. (PMC)
Prostate cancer is a medical condition caused by irregular cell growth in the tissues of the prostate.
The prostate is a male reproductive gland that plays a critical role in the contribution of nutrients and fluid to sperm.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper prostate gland layers to induce metastasis via blood and lymph.
At the early stage, due to the very small size of the tumor, prostate cancer is asymptomatic.
The most common symptoms of the prostate at the later stage are frequent urination and weak or interrupted urine flow due to the tumor that affects the tube surrounded by the prostate.
In some cases, patients may experience symptoms of blood in the urine and pain due to the oversized tumor that has pressed on the nearby blood vessels and nerve cells.
The new onset of erectile dysfunction is also common in patients with prostate cancer.
The causes of prostate cancer are not identified. However, the increase in aging is one of the most common risk factors as most cases of the condition are diagnosed in older adults. Approximately, 60% of all cases are diagnosed in men over 65.c
According to the statistics, in 2017, 21,300 men were diagnosed with prostate cancer, and the disease caused the death of 4,100 men in the same year.
The 5-year survival rate for most men with local or regional prostate cancer is nearly 100% compared to only 30% in patients diagnosed with prostate cancer that has spread to other parts of the body,
Some researchers concerned that the risk of prostate cancer in the younger population suggested that the promotion of a high-fat diet over the past few decades may be correlated to the rise of the disease.
Dr. Colleen Pelser, the lead scientist wrote, "Total fat and mono- and polyunsaturated fat INTAKES were not associated with the incidence of prostate cancer. Saturated fat intake was related to increased risk of advanced prostate cancer (HRQuintile 5 vs. Quintile 1 (Q1 vs. Q5)1.21; 95% CI 1.00–1.46; p-for-trend=0.03) and fatal prostate cancer".
And. "Our study suggests that the associations of fat and fatty acids differ by prostate cancer severity. Saturated fat, ALA, and EPA intakes were related to the risk of advanced or fatal prostate cancer, but not to non-advanced prostate cancer".
The results strongly suggested that if you are a high-fat diet follower, your risk of prostate cancer is increased substantially compared to a traditional diet.
Tomato is a red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural compound for the treatment of prostate cancer, researchers investigated the effects of lycopene-rich tomato on prostate-specific antigen (PSA) in prostate cancer patients.
The study included 79 patients with prostate cancer randomized to a nutritional intervention with either 1) tomato products containing 30 mg lycopene per day; 2) tomato products plus selenium, omega-3 fatty acids, soy isoflavones, grape/pomegranate juice, and green/black tea (tomato-plus); or 3) control diet for 3 weeks.
According to the results of the test, the tomato group showed a significant PSA decrease compared to controls.
Compared to other groups, median PSA values decreased by 1% in patients with the highest increases in plasma lycopene, selenium, and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium, and C20:5 n-3 fatty acid.
In other words, PSA decreased the most in patients with the highest increase in lycopene alone.
Based on the findings, researchers said, "Three-week nutritional interventions with tomato products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer".
Moreover, in the investigation of the association between tomato consumption and prostate cancer risk, researchers at Zhejiang University performed a meta-analysis to comprehensively evaluate this relationship.
Geographically, tomato intake showed significant protective effects in patients of Asian origin and Oceania populations compared to other regions.
According to the total of 24 published studies with 15,099 cases, tomato intake was associated with a reduced risk of prostate cancer with RRs of 0.76 found in the case-control and cohort studies.
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA by Paur I1, Lilleby W2, Bøhn SK3, Hulander E4, Klein W5, Vlatkovic L6, Axcrona K7, Bolstad N8, Bjøro T9, Laake P10, Taskén KA11, Svindland A12, Eri LM13, Brennhovd B14, Carlsen MH15, Fosså SD16, Smeland SS17, Karlsen AS18, Blomhoff R. (PubMed)
(2) Tomato consumption and prostate cancer risk: a systematic review and meta-analysis by Xu X1, Li J1, Wang X1, Wang S1, Meng S1, Zhu Y1, Liang Z1, Zheng X1, Xie L. (PubMed)
(3). Dietary Fat, Fatty Acids and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study
Colleen Pelser,1 Alison M. Mondul,2 Albert R. Hollenbeck,3 and Yikyung Park. (PMC)
#Alliin From Garlic Powder Shows a Significant Effect on #Hypertension, Researchers Suggest
Kyle J. Norton
Hypertension, found in the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.
Blood pressure change constantly depending on the activity. Persistent hypertension over time can lead to diabetes and cardiovascular disease.
It also is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association., approximately a million U.S. adults are living with high blood pressure, accounting to nearly half of all adults in the United States.
Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications have caused many side effects such as damaging the kidney.
Epidemiologically, family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet, and people with chronic kidney disease are some common risk factors involved in the increased risk of hypertension.
Believe it or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.
Dr. Kazim Husain wrote, "Several possible mechanisms have been proposed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angiotensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracellular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production".
And, "Loss of relaxation due to inflammation and oxidative injury of the endothelium by angiotensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributor of alcohol-induced hypertension".
In fact, by making changes to lifestyle, maintaining an ideal weight, and diet with low salt, you could do just fine without the drugs.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) in rats fed with a high cholesterol diet.
The study was carried out with rats fed a 2% high cholesterol diet with and without garlic powder and control rats were fed a normal diet for 6 weeks daily.
Rats treated with a high-cholesterol diet had significantly higher blood pressure compared to the animals receiving the control diet.
Compared to the high cholesterol and control diet group, the blood pressure of the animals receiving garlic powder was significantly lower without changing the levels of serum glucose and protein in all of the rats.
The results strongly showed support for the use of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6 % allicin) for the treatment of systolic blood pressure in hypercholesterolemic in an animal model.
Dr. Ali M the lead scientist said, "Our experimental results show that garlic may beneficially affect .....hypertension".
Taken together, alliin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Intake of Alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) Alcohol-induced hypertension: Mechanism and prevention by Kazim Husain, Rais A Ansari, and Leon Ferder. (PMC)
Hypertension, found in the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.
Blood pressure change constantly depending on the activity. Persistent hypertension over time can lead to diabetes and cardiovascular disease.
It also is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association., approximately a million U.S. adults are living with high blood pressure, accounting to nearly half of all adults in the United States.
Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications have caused many side effects such as damaging the kidney.
Epidemiologically, family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet, and people with chronic kidney disease are some common risk factors involved in the increased risk of hypertension.
Believe it or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.
Dr. Kazim Husain wrote, "Several possible mechanisms have been proposed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angiotensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracellular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production".
And, "Loss of relaxation due to inflammation and oxidative injury of the endothelium by angiotensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributor of alcohol-induced hypertension".
In fact, by making changes to lifestyle, maintaining an ideal weight, and diet with low salt, you could do just fine without the drugs.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) in rats fed with a high cholesterol diet.
The study was carried out with rats fed a 2% high cholesterol diet with and without garlic powder and control rats were fed a normal diet for 6 weeks daily.
Rats treated with a high-cholesterol diet had significantly higher blood pressure compared to the animals receiving the control diet.
Compared to the high cholesterol and control diet group, the blood pressure of the animals receiving garlic powder was significantly lower without changing the levels of serum glucose and protein in all of the rats.
The results strongly showed support for the use of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6 % allicin) for the treatment of systolic blood pressure in hypercholesterolemic in an animal model.
Dr. Ali M the lead scientist said, "Our experimental results show that garlic may beneficially affect .....hypertension".
Taken together, alliin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Intake of Alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) Alcohol-induced hypertension: Mechanism and prevention by Kazim Husain, Rais A Ansari, and Leon Ferder. (PMC)
#Cranberry #Extracts Induce Apoptosis of #BreastCancer Cells, According to Studies
Kyle J. Norton
The women's breasts are made of tissues that produce milk (glandular tissue) and fat. The size of a woman's breast is totally depending on the amount of fat in the breast.
Cancer is a class of medical conditions associated with cell growth in the specific tissue of the gland and organ.
Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA that often begins in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage after colonizing the deeper layer of tissues to form a tumor through proliferation, invasive cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
The most common secondary cancers spread by primary breast cancer are bone, liver, lung, and brain cancer.
According to the statistics, in the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in 2019, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The lifetime risk of getting invasive breast cancer in the North America of a woman is 1/8.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified. Epidemiologically, aging, genetic proposition, female gender, family history, history of pregnancy, dense breast tissue, and smoking are some of the most prevalent factors that are found in patients with the disease.
However, some researchers who investigated the risk of breast cancer in obese patients suggested that the promotion of a high-fat diet that causes the increased incidences of obesity in the US may have a strongly negative impact to induce the onset of breast cancer in women.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of cancer, researchers examined the effect of the efficacy of cranberry phytochemical extracts significantly inhibited human breast cancer MCF-7 cells.
According to the tested differentiation, at doses of 5 to 30mg/mL, cranberry phytochemical extracts induced apoptosis in MCF-7 cells in a dose-dependent manner, after exposure for 4h.
Compared to the control group, cranberry phytochemical extracts at a dose of 50mg/mL exhibited an additional 25% higher ratio of apoptotic cells to total cells.
Furthermore, at doses from 10 to 50mg/mL cranberry phytochemical extracts exerted significantly arrested MCF-7 cells at G0/G1 phase.
Moreover, A constant increasing pattern of the G1/S index was observed in the cranberry extract treatment group compared to the decrease of the G1/S ratio of the control group between 10 and 24h treatment.
Additionally, according to the cell cycle division analysis, cranberry extracts induced cell cycle arrest in the G1/S in MCF-7 cells was approximately 6 times higher than that of the control group.
Based on the findings, researchers after taking other factors into account said," These results suggest that cranberry phytochemical extracts possess the ability to suppress the proliferation of human breast cancer MCF-7 cells, and this suppression is at least partly attributed to both the initiation of apoptosis and the G1 phase arrest".
Taken together, cranberry may be considered a remedy for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells by Sun J1, Hai Liu R. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
The women's breasts are made of tissues that produce milk (glandular tissue) and fat. The size of a woman's breast is totally depending on the amount of fat in the breast.
Cancer is a class of medical conditions associated with cell growth in the specific tissue of the gland and organ.
Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA that often begins in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage after colonizing the deeper layer of tissues to form a tumor through proliferation, invasive cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
The most common secondary cancers spread by primary breast cancer are bone, liver, lung, and brain cancer.
According to the statistics, in the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in 2019, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The lifetime risk of getting invasive breast cancer in the North America of a woman is 1/8.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified. Epidemiologically, aging, genetic proposition, female gender, family history, history of pregnancy, dense breast tissue, and smoking are some of the most prevalent factors that are found in patients with the disease.
However, some researchers who investigated the risk of breast cancer in obese patients suggested that the promotion of a high-fat diet that causes the increased incidences of obesity in the US may have a strongly negative impact to induce the onset of breast cancer in women.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of cancer, researchers examined the effect of the efficacy of cranberry phytochemical extracts significantly inhibited human breast cancer MCF-7 cells.
According to the tested differentiation, at doses of 5 to 30mg/mL, cranberry phytochemical extracts induced apoptosis in MCF-7 cells in a dose-dependent manner, after exposure for 4h.
Compared to the control group, cranberry phytochemical extracts at a dose of 50mg/mL exhibited an additional 25% higher ratio of apoptotic cells to total cells.
Furthermore, at doses from 10 to 50mg/mL cranberry phytochemical extracts exerted significantly arrested MCF-7 cells at G0/G1 phase.
Moreover, A constant increasing pattern of the G1/S index was observed in the cranberry extract treatment group compared to the decrease of the G1/S ratio of the control group between 10 and 24h treatment.
Additionally, according to the cell cycle division analysis, cranberry extracts induced cell cycle arrest in the G1/S in MCF-7 cells was approximately 6 times higher than that of the control group.
Based on the findings, researchers after taking other factors into account said," These results suggest that cranberry phytochemical extracts possess the ability to suppress the proliferation of human breast cancer MCF-7 cells, and this suppression is at least partly attributed to both the initiation of apoptosis and the G1 phase arrest".
Taken together, cranberry may be considered a remedy for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells by Sun J1, Hai Liu R. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
#Tomatoes Inhibit Pro-Inflammatory Expression Associated with Obesity-Related Co-Morbidities, Researchers Show
Kyle J. Norton
Obesity is a disease characterized by excess body fat that has accumulated over time. A BMI of over 30 is an indication of obesity.
Overweight is a condition of excess body weight relative to height, a BMI that is between 25 to 29.9 is considered overweight.
According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects in nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity continues to climb at an alarming rate, which leads to significant burdens to the country's economy and health care system.
Currently, there is no effective treatment for the disease. However, some researchers suggested that combating the powerful environmental factors that influence eating and physical activity, particularly in the economy may be the best approach to reduce the risk of obesity.
Bariatric surgery has been proposed for patients with extreme obesity (BMI of 40 or higher) due to weight-induced serious weight-related health problems, such as diabetes or high blood pressure accompanied by the commitment to lifestyle changes. However, this type of surgery has posed a serious risk to many patients if the commitment to making lifelong changes in their eating and exercise habits cannot be followed through.
There are many risk factors associated with the onset of obesity. Some researchers suggested that the widespread obesity in the US may be correlated to the promotion of high-fat diets over the past few decades.
Dr, Golay A, the lead scientist at the Geneva University Hospital, wrote, "Epidemiological evidence suggests that a high-fat diet promotes the development of obesity and that there is a direct relationship between the amount of dietary fat and the degree of obesity".
And, "Dietary fat induces overconsumption and weight gain through its low satiety properties and high caloric density. Obese and post-obese subjects do not appear to adapt to dietary fat, and therefore fat storage is increased".
Tomato is a red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In finding a natural and potential compound for the treatment of obesity complications, researchers investigated the effect of the potent tomato-derived antioxidant and oxidative status, and inflammatory markers in obese.
The study included the comparison of 8 obese patients (body mass index 37.5 +/- 2.5 kg/m2) with a control group of eight lean, age and gender-matched subjects (BMI 21.6 +/- 0.6 kg/m2), before and after 4 weeks of lycopene supplementation (tomato-derived Lyc-O-Mato) (30 mg daily).
Before treatment, according to the tested results, compared to control, obese subjects showed significantly reduced levels of plasma carotenoids, increased levels of CRP, and expression of pro-inflammatory cytokine and oxidative stress.
Additional analysis of the findings, BMI was correlated with increased expression of CRP, proinflammation (IL-6), and oxidative stress.
The presence of high levels of IL-6 and oxidative stress was also found to correlate inversely with carotenoids (P < 0.05).
In other words, obese-induced increased levels of CRP, IL-6, and oxidative stress were attributed probably to the depletion of antioxidant enzymes produced by the host.
After treatment, lycopene had a significant elevation of plasma carotenoids (1.79 vs. 0.54 microg/ml) and plasma of lycopene (1.15 vs 0.23 microg/ml) in the subjects compared to the placebo group.
The results suggested that injection of lycopene improved the levels of antioxidant enzymes in the obese, thus preventing the occurrence of diseases associated with CRP, IL-6, and oxidative stress without affecting the markers of inflammation and oxidation products.
Based on the results, researchers concluded, "Obese patients showed abnormally higher markers of inflammation and oxidation products and lower plasma carotenoids".
And, "The lack of reduction of pro-inflammatory markers could be attributed to the short period of the study and the small number of participants".
Taken together, tomatoes processed with a high amount of lycopene may be considered supplements for the prevention of obesity-related co-morbidities, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity by Markovits N1, Ben Amotz A, Levy Y. (PubMed)
(2) The role of dietary fat in obesity by Golay A1, Bobbioni E. (PubMed)
Obesity is a disease characterized by excess body fat that has accumulated over time. A BMI of over 30 is an indication of obesity.
Overweight is a condition of excess body weight relative to height, a BMI that is between 25 to 29.9 is considered overweight.
According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects in nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity continues to climb at an alarming rate, which leads to significant burdens to the country's economy and health care system.
Currently, there is no effective treatment for the disease. However, some researchers suggested that combating the powerful environmental factors that influence eating and physical activity, particularly in the economy may be the best approach to reduce the risk of obesity.
Bariatric surgery has been proposed for patients with extreme obesity (BMI of 40 or higher) due to weight-induced serious weight-related health problems, such as diabetes or high blood pressure accompanied by the commitment to lifestyle changes. However, this type of surgery has posed a serious risk to many patients if the commitment to making lifelong changes in their eating and exercise habits cannot be followed through.
There are many risk factors associated with the onset of obesity. Some researchers suggested that the widespread obesity in the US may be correlated to the promotion of high-fat diets over the past few decades.
Dr, Golay A, the lead scientist at the Geneva University Hospital, wrote, "Epidemiological evidence suggests that a high-fat diet promotes the development of obesity and that there is a direct relationship between the amount of dietary fat and the degree of obesity".
And, "Dietary fat induces overconsumption and weight gain through its low satiety properties and high caloric density. Obese and post-obese subjects do not appear to adapt to dietary fat, and therefore fat storage is increased".
Tomato is a red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In finding a natural and potential compound for the treatment of obesity complications, researchers investigated the effect of the potent tomato-derived antioxidant and oxidative status, and inflammatory markers in obese.
The study included the comparison of 8 obese patients (body mass index 37.5 +/- 2.5 kg/m2) with a control group of eight lean, age and gender-matched subjects (BMI 21.6 +/- 0.6 kg/m2), before and after 4 weeks of lycopene supplementation (tomato-derived Lyc-O-Mato) (30 mg daily).
Before treatment, according to the tested results, compared to control, obese subjects showed significantly reduced levels of plasma carotenoids, increased levels of CRP, and expression of pro-inflammatory cytokine and oxidative stress.
Additional analysis of the findings, BMI was correlated with increased expression of CRP, proinflammation (IL-6), and oxidative stress.
The presence of high levels of IL-6 and oxidative stress was also found to correlate inversely with carotenoids (P < 0.05).
In other words, obese-induced increased levels of CRP, IL-6, and oxidative stress were attributed probably to the depletion of antioxidant enzymes produced by the host.
After treatment, lycopene had a significant elevation of plasma carotenoids (1.79 vs. 0.54 microg/ml) and plasma of lycopene (1.15 vs 0.23 microg/ml) in the subjects compared to the placebo group.
The results suggested that injection of lycopene improved the levels of antioxidant enzymes in the obese, thus preventing the occurrence of diseases associated with CRP, IL-6, and oxidative stress without affecting the markers of inflammation and oxidation products.
Based on the results, researchers concluded, "Obese patients showed abnormally higher markers of inflammation and oxidation products and lower plasma carotenoids".
And, "The lack of reduction of pro-inflammatory markers could be attributed to the short period of the study and the small number of participants".
Taken together, tomatoes processed with a high amount of lycopene may be considered supplements for the prevention of obesity-related co-morbidities, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity by Markovits N1, Ben Amotz A, Levy Y. (PubMed)
(2) The role of dietary fat in obesity by Golay A1, Bobbioni E. (PubMed)
#Healthyfood #Onions Inhibit Cholesterol Parameters Associated with Cholesterol Gallstone Formation, Researchers Suggest
Kyle J. Norton
Cholesterol gallstones caused by the accumulation of cholesterol in the gallbladder are the most common type of gallstone with yellow in color.
Gallstone is a condition caused by the hardening of deposits of digestive fluid formed in the gallbladder.
The digestive fluid or bile is produced by the gallbladder that released into the small intestine to aid digestion.
If the cholesterol gallstone blocks the gallbladder duct, it can induce symptoms of cudden and rapidly intensifying pain in the upper right portion of your abdomen and intensifying pain in the center of your abdomen, and pain between your shoulder blades and right shoulder.
Some patients may also experience gastrointestinal symptoms such as nausea and vomiting.
Conventionally, surgery for cholesterol gallstones is only for patients who have experienced symptoms of pain.
Some researchers suggested there are evidence that the rise of cholesterol gallstone in the US may
be correlated to the promotion of the Western diet over the past few decades.
Dr. Yongsoon Park wrote, "Patients with cholesterol gallstone consumed more lipid, animal lipid, beef, pork, and fried food than those with pigment gallstones and control, while patients with pigment gallstone consumed more carbohydrate and noodles than patients with cholesterol gallstone and control".
And, "consumption of fat from meat and fried foods increased the risk of cholesterol gallstone, and intake of carbohydrate from noodles increased the risk of pigment gallstone".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention of cholesterol gallstone formation, researchers evaluated the anti-lithogenic effect of a combination of dietary fenugreek seeds and onion.
The study included Lithogenesis induced mice fed with a high (0.5%) cholesterol diet (HCD) for 10 weeks with Fenugreek (12%) and onion (2%) included individually and in combination in this HCD.
According to the tested analysis,
* Fenugreek, onion, and their combination reduced the incidence of cholesterol gallstones by 75%, 27%, and 76%, respectively.
*Total cholesterol content in mice fed with Fenugreek, onion, and their combination was also reduced by 38-42%, 50-72%, and 61-80%, respectively.
* These results have a strong effect on the reduction of cholesterol/phospholipid ratio involved in gallstone formation in serum, liver, and bile.
* The cholesterol saturation index of bile was reduced from 4.14 to 1.38 and 2,33 in mice fed with the combination of fenugreek and onion respectively.
* The phospholipid and bile acid contents of the bile were increased in all groups.
* Hepatic lipid peroxidation was reduced by 19-22% and 39-45% with fenugreek, onion and their combination included in the diet along with the HCD.
* Interestingly, the increased accumulation of fat in the liver and inflammation of the gallbladder membrane produced by HCD was totally reduced by fenugreek, onion, and their combination.
Based on the results, researchers suggested that Fenugreek and onion inhibited the parameters involved in the cholesterol formation of gallstones.
After taking into account of co and confounders, Dr. Reddy RR, the lead scientist wrote, "The anti-lithogenic influence was highest with fenugreek alone, and the presence of onion along with it did not further increase this effect".
According to Dr. Vidyashankar S, the lead researcher in the study of cholesterol gallstones by dietary garlic and onion in mice fed with a lithogenic diet for 10 weeks, the efficacy of onion in the inhibition of cholesterol formation of gallstone stones was attributed to the acceleration of the regression of preformed CGS by promoting cholesterol desaturation in bile.
Taken together, onion may be considered a remedy for the prevention of cholesterol gallstone formation, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary fenugreek and onion attenuate cholesterol gallstone formation in lithogenic diet-fed mice by Reddy RR1, Srinivasan K. (PubMed)
(2) Regression of preestablished cholesterol gallstones by dietary garlic and onion in experimental mice by Vidyashankar S1, Sambaiah K, Srinivasan K. (PubMed)
(3) Association between diet and gallstones of cholesterol and pigment among patients with cholecystectomy: a case-control study in Korea by Yongsoon Park,
#1 Doyeon Kim,1 Ju Seon Lee,1 Yu Na Kim,1 Yoon Kyung Jeong,2Kyeong Geun Lee,2 and Dongho Choi. (PMC)
Cholesterol gallstones caused by the accumulation of cholesterol in the gallbladder are the most common type of gallstone with yellow in color.
Gallstone is a condition caused by the hardening of deposits of digestive fluid formed in the gallbladder.
The digestive fluid or bile is produced by the gallbladder that released into the small intestine to aid digestion.
If the cholesterol gallstone blocks the gallbladder duct, it can induce symptoms of cudden and rapidly intensifying pain in the upper right portion of your abdomen and intensifying pain in the center of your abdomen, and pain between your shoulder blades and right shoulder.
Some patients may also experience gastrointestinal symptoms such as nausea and vomiting.
Conventionally, surgery for cholesterol gallstones is only for patients who have experienced symptoms of pain.
Some researchers suggested there are evidence that the rise of cholesterol gallstone in the US may
be correlated to the promotion of the Western diet over the past few decades.
Dr. Yongsoon Park wrote, "Patients with cholesterol gallstone consumed more lipid, animal lipid, beef, pork, and fried food than those with pigment gallstones and control, while patients with pigment gallstone consumed more carbohydrate and noodles than patients with cholesterol gallstone and control".
And, "consumption of fat from meat and fried foods increased the risk of cholesterol gallstone, and intake of carbohydrate from noodles increased the risk of pigment gallstone".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention of cholesterol gallstone formation, researchers evaluated the anti-lithogenic effect of a combination of dietary fenugreek seeds and onion.
The study included Lithogenesis induced mice fed with a high (0.5%) cholesterol diet (HCD) for 10 weeks with Fenugreek (12%) and onion (2%) included individually and in combination in this HCD.
According to the tested analysis,
* Fenugreek, onion, and their combination reduced the incidence of cholesterol gallstones by 75%, 27%, and 76%, respectively.
*Total cholesterol content in mice fed with Fenugreek, onion, and their combination was also reduced by 38-42%, 50-72%, and 61-80%, respectively.
* These results have a strong effect on the reduction of cholesterol/phospholipid ratio involved in gallstone formation in serum, liver, and bile.
* The cholesterol saturation index of bile was reduced from 4.14 to 1.38 and 2,33 in mice fed with the combination of fenugreek and onion respectively.
* The phospholipid and bile acid contents of the bile were increased in all groups.
* Hepatic lipid peroxidation was reduced by 19-22% and 39-45% with fenugreek, onion and their combination included in the diet along with the HCD.
* Interestingly, the increased accumulation of fat in the liver and inflammation of the gallbladder membrane produced by HCD was totally reduced by fenugreek, onion, and their combination.
Based on the results, researchers suggested that Fenugreek and onion inhibited the parameters involved in the cholesterol formation of gallstones.
After taking into account of co and confounders, Dr. Reddy RR, the lead scientist wrote, "The anti-lithogenic influence was highest with fenugreek alone, and the presence of onion along with it did not further increase this effect".
According to Dr. Vidyashankar S, the lead researcher in the study of cholesterol gallstones by dietary garlic and onion in mice fed with a lithogenic diet for 10 weeks, the efficacy of onion in the inhibition of cholesterol formation of gallstone stones was attributed to the acceleration of the regression of preformed CGS by promoting cholesterol desaturation in bile.
Taken together, onion may be considered a remedy for the prevention of cholesterol gallstone formation, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary fenugreek and onion attenuate cholesterol gallstone formation in lithogenic diet-fed mice by Reddy RR1, Srinivasan K. (PubMed)
(2) Regression of preestablished cholesterol gallstones by dietary garlic and onion in experimental mice by Vidyashankar S1, Sambaiah K, Srinivasan K. (PubMed)
(3) Association between diet and gallstones of cholesterol and pigment among patients with cholecystectomy: a case-control study in Korea by Yongsoon Park,
#1 Doyeon Kim,1 Ju Seon Lee,1 Yu Na Kim,1 Yoon Kyung Jeong,2Kyeong Geun Lee,2 and Dongho Choi. (PMC)
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