Kyle J. Norton
Cholesterol produced by the liver and from the dietary sources is needed for the cell to build a strong membrane, produce steroid hormone, bile acids, and vitamin D and aid the digestive functioning.
Most people with high blood cholesterol at an early do not experience any symptoms, however, as the levels of blood cholesterol continue to grow, at some points, patients may experience heart-related symptoms, including chest pain or angina, pain while walking caused by reduced blood flow to the legs.
In serious cases, elevated blood cholesterol can also induce symptoms of stroke and heart attack.
There are 2 types of blood cholesterol
* Low-density lipoprotein (LDL) also is known as “bad cholesterol”. Bad cholesterol is a major cause of plaque build-up in the arteries and a leading cause of coronary heart disease.
*High-density lipoprotein (HDL) is known as “good cholesterol”. HDL removes LDL cholesterol from your arteries back to the liver.
The healthy ratio of blood cholesterol is 4 LDL)/ 1HLD
Besides a high-fat diet, certain risk factors such as a family history of high cholesterol, being overweight or obese, physical inactivity, excessive alcohol intake, smoking, and some health conditions including diabetes, kidney disease, and liver disease have been found to increase the risk of high blood cholesterol.
Epidemiological studies also suggested that a high level of blood cholesterol is associated with an increased risk of cardiovascular disease.
The endothelium is a thin membrane that lines the inside of the heart and blood vessels. The endothelium cells process an essential function in controlling vascular relaxation and contraction.
Furthermore, the endothelium cells also control enzymes associated with blood clotting, immune function, and platelet adhesion.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of prostate diseases, researchers examined the effect of chronic cranberry juice consumption on cholesterol profiles and vascular functions in an estrogen-deficient animal model.
The study included ovariectomized rats that were treated daily with commercial cranberry juice at 7 mg/kg for 8 weeks, a dosage comparable to recent clinical studies.
According to the tested analysis, cranberry juice consumption reduced circulating levels of total cholesterol, triacylglycerols, HDL, nHDL, and nHDL/HDL ratio.
Furthermore, cranberry juice consumption improved endothelium-dependent relaxation in the aorta of ovariectomized rats by restoring p-eNOS level (endothelial nitric oxide synthase.
Overexpression of renin-angiotensin system markers (angiotensin-converting enzyme, angiotensin II, and angiotensin II type 1 receptor) associated with blood pressure was also inhibited by commercial cranberry juice.
Furthermore, commercial cranberry juice also normalizes the elevated NAD(P)H oxidase expression and oxidative stress involved in the increased levels of ROS.
Based on the findings, researchers concluded. " the novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles".
Taken together, cranberry may be considered a remedy for the prevention and treatment of cardiovascular disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats by Yung LM1, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Vanhoutte PM, Yao X, Huang Y. (PubMed)
Saturday, 26 August 2023
#Healthy #Tomatoes Antixodant Levels Depend on the Levels of PhenolicCompounds, Researchers Find
Kyle J. Norton
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibit the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.
Antioxidants can either be produced by the liver or taken from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.
There are 3 main types of antioxidants found in nature, including
* Antioxidant enzymes produced by the host, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases.
* Antioxidants vitamins, that may be injected from dietary sources such as fruits and vegetables, including vitamins A, C, D, and E. Most antioxidant vitamins are considered free radical scavengers that gobble up free radicals before they can induce a cascade of damage.
* Antioxidant Phytochemicals found in the plant including second metabolites.
Antioxidants keep our bodies functioning properly by reducing the risk of diseases associated with oxidative stress.
Dr. Esra Birben, the lead scientist in the evaluation of oxidative stress and antioxidant defense wrote, "Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabolism and environmental factors, such as air pollutants or cigarette smoke. ROS are highly reactive molecules and can damage cell structures such as carbohydrates, nucleic acids, lipids, and proteins and alter their functions. The shift in the balance between oxidants and antioxidants in favor of oxidants is termed “oxidative stress".
And, "Aerobic organisms have integrated antioxidant systems, which include enzymatic and nonenzymatic antioxidants that are usually effective in blocking the harmful effects of ROS. However, in pathological conditions, the antioxidant systems can be overwhelmed. Oxidative stress contributes to many pathological conditions and diseases, including cancer, neurological disorders, atherosclerosis, hypertension, ischemia/perfusion, diabetes, acute respiratory distress syndrome, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and asthma".
In other words, we can say goodbye to the diseases involved in oxidative stress by maintaining the proper ratio of free radicals and antioxidants in the body.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient with the best antioxidant activity, researchers compared the parental line, for antioxidant levels in fresh and hot break fruit, and the bioaccessibility of antioxidants from the puree.
Believe it or not, there are Differences found in the concentrations of antioxidants between the wild-type and the genetically modified raw tomatoes.
However, compared to the parent of BM tomatoes, GM tomatoes were found to maintain antioxidant levels to a greater extent in the puree and in vitro digestion model, the levels of antioxidants showed an increase in the genetically modified samples, according to the bioaccessibility of the analysis of the compounds.
Although researchers found that GM tomatoes processed similar or better antioxidant levels compared to the parent, they do not mention the possibility of toxicity of the genetically modified samples.
In vivo, the antioxidant activity of several types of tomato taken from the Andean valleys was tested on Caenorhabditis Elegans subjected to thermal stress, researchers found the metabolite composition of tomatoes are totally depending on the geographical origin and fruit size.
The antioxidant activity of tomatoes also depends on the phenolic compounds, such as caffeoylquinic acids, ferulic acid-O-hexoses, and rutin which are associated with the fruit size, and geographical origin.
The findings suggested that all tomatoes process different levels of phytochemicals that may affect the antioxidant properties, depending on the size and type.
Taken together, tomatoes processed with abundantly bioactive compounds may be considered an antioxidant supplement against oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant compounds and their bioaccessibility in tomato fruit and puree obtained from a DETIOLATED-1 (DET-1) down-regulated genetically modified genotype by Talens P1, Mora L2, Bramley PM2, Fraser PD. (PubMed)
(2) Hydrophilic antioxidants from Andean tomato landraces assessed by their bioactivities in vitro and in vivo by Di Paola Naranjo RD1, Otaiza S2, Saragusti AC2, Baroni V3, Carranza Adel V2, Peralta IE4, Valle EM5, Carrari F6, Asis R. (PubMed)
(3) Oxidative Stress and Antioxidant Defense by Esra Birben, PhD,1 Umit Murat Sahiner, MD,1 Cansin Sackesen, MD,1 Serpil Erzurum, MD,2and Omer Kalayci, MD. (PMC)
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibit the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.
Antioxidants can either be produced by the liver or taken from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.
There are 3 main types of antioxidants found in nature, including
* Antioxidant enzymes produced by the host, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases.
* Antioxidants vitamins, that may be injected from dietary sources such as fruits and vegetables, including vitamins A, C, D, and E. Most antioxidant vitamins are considered free radical scavengers that gobble up free radicals before they can induce a cascade of damage.
* Antioxidant Phytochemicals found in the plant including second metabolites.
Antioxidants keep our bodies functioning properly by reducing the risk of diseases associated with oxidative stress.
Dr. Esra Birben, the lead scientist in the evaluation of oxidative stress and antioxidant defense wrote, "Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabolism and environmental factors, such as air pollutants or cigarette smoke. ROS are highly reactive molecules and can damage cell structures such as carbohydrates, nucleic acids, lipids, and proteins and alter their functions. The shift in the balance between oxidants and antioxidants in favor of oxidants is termed “oxidative stress".
And, "Aerobic organisms have integrated antioxidant systems, which include enzymatic and nonenzymatic antioxidants that are usually effective in blocking the harmful effects of ROS. However, in pathological conditions, the antioxidant systems can be overwhelmed. Oxidative stress contributes to many pathological conditions and diseases, including cancer, neurological disorders, atherosclerosis, hypertension, ischemia/perfusion, diabetes, acute respiratory distress syndrome, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and asthma".
In other words, we can say goodbye to the diseases involved in oxidative stress by maintaining the proper ratio of free radicals and antioxidants in the body.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient with the best antioxidant activity, researchers compared the parental line, for antioxidant levels in fresh and hot break fruit, and the bioaccessibility of antioxidants from the puree.
Believe it or not, there are Differences found in the concentrations of antioxidants between the wild-type and the genetically modified raw tomatoes.
However, compared to the parent of BM tomatoes, GM tomatoes were found to maintain antioxidant levels to a greater extent in the puree and in vitro digestion model, the levels of antioxidants showed an increase in the genetically modified samples, according to the bioaccessibility of the analysis of the compounds.
Although researchers found that GM tomatoes processed similar or better antioxidant levels compared to the parent, they do not mention the possibility of toxicity of the genetically modified samples.
In vivo, the antioxidant activity of several types of tomato taken from the Andean valleys was tested on Caenorhabditis Elegans subjected to thermal stress, researchers found the metabolite composition of tomatoes are totally depending on the geographical origin and fruit size.
The antioxidant activity of tomatoes also depends on the phenolic compounds, such as caffeoylquinic acids, ferulic acid-O-hexoses, and rutin which are associated with the fruit size, and geographical origin.
The findings suggested that all tomatoes process different levels of phytochemicals that may affect the antioxidant properties, depending on the size and type.
Taken together, tomatoes processed with abundantly bioactive compounds may be considered an antioxidant supplement against oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant compounds and their bioaccessibility in tomato fruit and puree obtained from a DETIOLATED-1 (DET-1) down-regulated genetically modified genotype by Talens P1, Mora L2, Bramley PM2, Fraser PD. (PubMed)
(2) Hydrophilic antioxidants from Andean tomato landraces assessed by their bioactivities in vitro and in vivo by Di Paola Naranjo RD1, Otaiza S2, Saragusti AC2, Baroni V3, Carranza Adel V2, Peralta IE4, Valle EM5, Carrari F6, Asis R. (PubMed)
(3) Oxidative Stress and Antioxidant Defense by Esra Birben, PhD,1 Umit Murat Sahiner, MD,1 Cansin Sackesen, MD,1 Serpil Erzurum, MD,2and Omer Kalayci, MD. (PMC)
#Hydroethanolic (HME) and #Acetone (AcE) Found in #Tomato Induces Cytotoxicity Against Cancer Cells through Their Antioxidant Activity, Scientists Suggest
Kyle J. Norton
Cytotoxicity is the process of the induction of cell death through toxins.
In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.
In normal, cytotoxicity can cause the death of healthy cells
In cancers, cytotoxicity can be beneficial to humans by destroying the cancer cells and preventing them from proliferation.
For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.
However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.
Dr. Shikha Srivastava, the lead scientist in the evaluation of the antioxidant and cytotoxic properties in Quercetin, wrote, "Quercetin interacts with DNA directly, and could be one of the mechanisms for inducing apoptosis in both, cancer cell lines and tumor tissues by activating the intrinsic pathway".
And, " quercetin-induced cytotoxicity in leukemic cells in a dose-dependent manner, while ellagic acid showed only limited toxicity. Besides leukemic cells, quercetin also induced cytotoxicity in breast cancer cells, however, its effect on normal cells was limited or none".
Scientifically, most cases of cancer cells cytotoxicity are associated with the stimulation of proteins and pathways involved in either gene suppression or cell death programming.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural ingredient that kills cancer without inducing adverse effects, researchers examined the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydroethanolic (HME), acetone (AcE), an alkaloid (AE) extracts prepared from the leaves of the tomato plant.
Both HME and AcE extracts showed a significant effect in scavenging •NO (IC50 values ranged from 0.87 ± 0.12 to 1.54 ± 0.23 and from 0.90 ± 0.01 to 2.23 ± 0.14 mg mL-1, respectively), compared to HMEs that only scavenge O2•- showing IC50 values from 0.12 ± ≤0.01 to 0.43 ± 0.08 mg mL-1.
In other words, tomato extracts demonstrated a strong effect against human gastric adenocarcinoma cells (AGS) through their cytotoxicity without causing harm to normal cells through the antioxidant activity.
Furthermore, in the study to assess different varieties of tomato seed extracts potential antioxidant and/or antiproliferative activity, researchers found that San Marzano Rosso seed extract displays the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition.
Moreover, according to the brine shrimp test (LD50: 23,198 ppm), San Marzano Rosso seed extract also demonstrated the highest cytotoxicity against the A375 cell line, compared to other varieties.
Taken altogether, tomato and its leaves may be considered supplements for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tomato in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells by Figueiredo-González M1, Valentão P1, Pereira DM1, Andrade PB. (PubMed)
(2) Antioxidant and cytotoxic activities investigation of tomato seed extracts by Tommonaro G1, Caporale A, De Martino L, Popolo A, De Prisco R, Nicolaus B, Abbamondi GR, Saturnino C. (PubMed)
(3) Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell. Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis by Shikha Srivastava, Ranganatha R. Somasagara, Mahesh Hegde, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary & Sathees C. Raghavan. (Scientific Report)
Cytotoxicity is the process of the induction of cell death through toxins.
In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.
In normal, cytotoxicity can cause the death of healthy cells
In cancers, cytotoxicity can be beneficial to humans by destroying the cancer cells and preventing them from proliferation.
For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.
However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.
Dr. Shikha Srivastava, the lead scientist in the evaluation of the antioxidant and cytotoxic properties in Quercetin, wrote, "Quercetin interacts with DNA directly, and could be one of the mechanisms for inducing apoptosis in both, cancer cell lines and tumor tissues by activating the intrinsic pathway".
And, " quercetin-induced cytotoxicity in leukemic cells in a dose-dependent manner, while ellagic acid showed only limited toxicity. Besides leukemic cells, quercetin also induced cytotoxicity in breast cancer cells, however, its effect on normal cells was limited or none".
Scientifically, most cases of cancer cells cytotoxicity are associated with the stimulation of proteins and pathways involved in either gene suppression or cell death programming.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural ingredient that kills cancer without inducing adverse effects, researchers examined the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydroethanolic (HME), acetone (AcE), an alkaloid (AE) extracts prepared from the leaves of the tomato plant.
Both HME and AcE extracts showed a significant effect in scavenging •NO (IC50 values ranged from 0.87 ± 0.12 to 1.54 ± 0.23 and from 0.90 ± 0.01 to 2.23 ± 0.14 mg mL-1, respectively), compared to HMEs that only scavenge O2•- showing IC50 values from 0.12 ± ≤0.01 to 0.43 ± 0.08 mg mL-1.
In other words, tomato extracts demonstrated a strong effect against human gastric adenocarcinoma cells (AGS) through their cytotoxicity without causing harm to normal cells through the antioxidant activity.
Furthermore, in the study to assess different varieties of tomato seed extracts potential antioxidant and/or antiproliferative activity, researchers found that San Marzano Rosso seed extract displays the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition.
Moreover, according to the brine shrimp test (LD50: 23,198 ppm), San Marzano Rosso seed extract also demonstrated the highest cytotoxicity against the A375 cell line, compared to other varieties.
Taken altogether, tomato and its leaves may be considered supplements for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tomato in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells by Figueiredo-González M1, Valentão P1, Pereira DM1, Andrade PB. (PubMed)
(2) Antioxidant and cytotoxic activities investigation of tomato seed extracts by Tommonaro G1, Caporale A, De Martino L, Popolo A, De Prisco R, Nicolaus B, Abbamondi GR, Saturnino C. (PubMed)
(3) Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell. Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis by Shikha Srivastava, Ranganatha R. Somasagara, Mahesh Hegde, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary & Sathees C. Raghavan. (Scientific Report)
#Healthfood #Tomato's #Lycopene Inhibits #Oxidativestress Associated with a Reduced Risk of #OvarianCancer, Scientists Show
Kyle J. Norton
Ovarian cancer is a medical condition caused by irregular cell growth in the lining tissues of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining of the ovary tissue before penetrating into deeper layers and colonizing the entire organ to induce secondary metastasis through blood and fluid circulation.
Ovarian cancer can be divided into the types below
* Epithelial Ovarian Cancer
The epithelial ovarian tumor also is known as a surface epithelial-stromal tumor, caused by the alternation of DNA of the cell on the surface of the ovary. Epithelial ovarian tumor is the most common form of ovarian cancer accounting for over 90% of all cases, including serious tumors, endometrioid tumors, and mucinous cystadenocarcinoma.
* Germ cell ovarian cancer
Germ cell ovarian tumor is a cancer of the egg-producing cells within the ovary and can be cancerous or non-cancerous tumors. The condition tends to occur in children and teens as a result of birth defects.
* Sex cord-stromal ovarian cancer
Sex cord-stromal ovarian tumor is a cancer of the tissue of the ovary that accounts for 8% of ovarian cancers. It is believed that the cancer is caused by excess estrogen produced by sex cord-stromal ovarian tumors. Sex cord-stromal ovarian cancer tends to develop in the older age group.
The most common symptoms of ovarian cancer are abdominal pain, bloating or swelling, quickly feeling full when eating, discomfort in the pelvis area, and change of bowel movement accompanied by the general symptoms shared by other cancers, such as unintended weight loss, gastrointestinal discomfort, loss of appetite and persistent fatigue.
Some researchers suggested that the widespread obesity caused by the promotion of a high-fat diet in the Western world may correlate to the increased risk of ovarian cancer.
Dr. Foong KW, wrote, " " 14 studies found a statistically significant positive association between ovarian cancer risk and higher body mass index, 26 studies found no significant association, and 3 studies found a negative association between ovarian cancer risk and higher body mass index".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of ovarian cancer, researchers investigated the combined effect of reduced graphene oxide-silver nanoparticles (rGO-AgNPs, with biomolecule called lycopene,) and trichostatin A (TSA) in human ovarian cancer cells (SKOV3).
According to the tested assays, AgNPs uniformly distributed on the surface of the graphene sheet with an average size between 10 and 50 nm, rGO-Ag, and TSA demonstrated significant inhibition of the cell viability in a dose-dependent manner.
At low concentrations, the combination of rGO-Ag and TSA not only had a significant effect on cell viability, and increased cytotoxicity but also inhibited the level of malondialdehyde (oxidative stress) and decreased the level of glutathione (antioxidants) that induced cancer cell mitochondrial dysfunction.
Based on the findings, researchers suggested, " This combination chemotherapy could be possibly used in advanced cancers that are not suitable for radiation therapy or surgical treatment and facilitate overcoming tumor resistance and disease progression".
Furthermore, the combination of rGO-Ag and TSA-induced cancer cell apoptosis was attributed to their pronounced effect on DNA fragmentation and double-strand breaks.
In order to reveal more information about lycopene, and anti-ovarian cancer activity scientists examined the protective role of dietary lycopene against the risk of ovarian cancer.
The search of the meta-analysis. identified 10 studies selected from the PubMed database, and final risk estimates, using a random-effects model showed that lycopene showed an effect on the risk of ovarian cancer among postmenopausal women, compared to an insignificant reverse association between dietary lycopene and ovarian cancer risk to other groups.
In other words, rGO-AgNPs, with a biomolecule called lycopene, are effective in reducing the risk and treatment of ovarian cancer in all groups compared to dietary lycopene in postmenopausal women.
Taken altogether, tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances the apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3) b yZhang XF1,2, Huang FH1, Zhang GL3, Bai DP4, Massimo DF5, Huang YF4, Gurunathan S. (PubMed)
(2) Meta-analysis of the association between dietary lycopene intake and ovarian cancer risk in postmenopausal women by Li X1, Xu J. (PubMed)
(3) Obesity and ovarian cancer risk: A systematic review by Foong KW1, Bolton H. (PubMed)
Ovarian cancer is a medical condition caused by irregular cell growth in the lining tissues of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining of the ovary tissue before penetrating into deeper layers and colonizing the entire organ to induce secondary metastasis through blood and fluid circulation.
Ovarian cancer can be divided into the types below
* Epithelial Ovarian Cancer
The epithelial ovarian tumor also is known as a surface epithelial-stromal tumor, caused by the alternation of DNA of the cell on the surface of the ovary. Epithelial ovarian tumor is the most common form of ovarian cancer accounting for over 90% of all cases, including serious tumors, endometrioid tumors, and mucinous cystadenocarcinoma.
* Germ cell ovarian cancer
Germ cell ovarian tumor is a cancer of the egg-producing cells within the ovary and can be cancerous or non-cancerous tumors. The condition tends to occur in children and teens as a result of birth defects.
* Sex cord-stromal ovarian cancer
Sex cord-stromal ovarian tumor is a cancer of the tissue of the ovary that accounts for 8% of ovarian cancers. It is believed that the cancer is caused by excess estrogen produced by sex cord-stromal ovarian tumors. Sex cord-stromal ovarian cancer tends to develop in the older age group.
The most common symptoms of ovarian cancer are abdominal pain, bloating or swelling, quickly feeling full when eating, discomfort in the pelvis area, and change of bowel movement accompanied by the general symptoms shared by other cancers, such as unintended weight loss, gastrointestinal discomfort, loss of appetite and persistent fatigue.
Some researchers suggested that the widespread obesity caused by the promotion of a high-fat diet in the Western world may correlate to the increased risk of ovarian cancer.
Dr. Foong KW, wrote, " " 14 studies found a statistically significant positive association between ovarian cancer risk and higher body mass index, 26 studies found no significant association, and 3 studies found a negative association between ovarian cancer risk and higher body mass index".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of ovarian cancer, researchers investigated the combined effect of reduced graphene oxide-silver nanoparticles (rGO-AgNPs, with biomolecule called lycopene,) and trichostatin A (TSA) in human ovarian cancer cells (SKOV3).
According to the tested assays, AgNPs uniformly distributed on the surface of the graphene sheet with an average size between 10 and 50 nm, rGO-Ag, and TSA demonstrated significant inhibition of the cell viability in a dose-dependent manner.
At low concentrations, the combination of rGO-Ag and TSA not only had a significant effect on cell viability, and increased cytotoxicity but also inhibited the level of malondialdehyde (oxidative stress) and decreased the level of glutathione (antioxidants) that induced cancer cell mitochondrial dysfunction.
Based on the findings, researchers suggested, " This combination chemotherapy could be possibly used in advanced cancers that are not suitable for radiation therapy or surgical treatment and facilitate overcoming tumor resistance and disease progression".
Furthermore, the combination of rGO-Ag and TSA-induced cancer cell apoptosis was attributed to their pronounced effect on DNA fragmentation and double-strand breaks.
In order to reveal more information about lycopene, and anti-ovarian cancer activity scientists examined the protective role of dietary lycopene against the risk of ovarian cancer.
The search of the meta-analysis. identified 10 studies selected from the PubMed database, and final risk estimates, using a random-effects model showed that lycopene showed an effect on the risk of ovarian cancer among postmenopausal women, compared to an insignificant reverse association between dietary lycopene and ovarian cancer risk to other groups.
In other words, rGO-AgNPs, with a biomolecule called lycopene, are effective in reducing the risk and treatment of ovarian cancer in all groups compared to dietary lycopene in postmenopausal women.
Taken altogether, tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances the apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3) b yZhang XF1,2, Huang FH1, Zhang GL3, Bai DP4, Massimo DF5, Huang YF4, Gurunathan S. (PubMed)
(2) Meta-analysis of the association between dietary lycopene intake and ovarian cancer risk in postmenopausal women by Li X1, Xu J. (PubMed)
(3) Obesity and ovarian cancer risk: A systematic review by Foong KW1, Bolton H. (PubMed)
#Curcumin Isolated from #Turmeric Inhibits #EndometrialCancer Cell Migration, Proliferation and Invasion, According to Studies
Kyle J. Norton
Cancer is a group of chronic diseases characterized by cell growth disorderly and uncontrollably in the body tissue of a specific organ.
Over time, after growing in size through unlimited division, the tumor can spread to other tissues and organs in the body via lymph or blood.
Endometrium, the inner lining of women's uterus is very susceptible to hormone change, particularly in the stages of the menstrual cycle.
Endometrial cancer is a late adulthood cancer that starts in the cells on the surface of the endometrial inner lining of the uterus caused by the alternation of the cell's DNA. Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
In the US, according to statistics, the average age of women diagnosed with endometrial cancer is 60. Endometrial cancer is more common in white women, but black women diagnosed with endometrial cancer are more likely to die from it.
There are more than 600,000 women endometrial cancer survivors in the US today. In 2019, approximately 61,880 new cases of cancer in the uterus (uterine body or corpus) will be diagnosed and this cancer will cause the death of 12,160 women.
Accompanied by the general symptoms shared by other types of cancer, the most common symptoms of endometrial cancer are
* Abnormal vaginal bleeding
Vaginal bleeding during the period with inappropriate amounts of blood flow should be checked with the doctor as soon as possible. The symptom may be caused by the expansion of overgrowth of pre-cancer uterine lining cells due to infection or breaking off the endometrial capillaries or blood vessels.
* Increase the amount of vaginal discharge
An increase in the amount of vaginal discharge accompanied by abnormal odor or pain, itching, or burning sensation may be caused by infection or inflammation.
* Painful urination
Painful urination, most of the time is caused by infection of the urinary tract that affects the bladder in emptying, but sometimes it can be caused by infectious diseases.
* Pain during sex
Painful during Most of the time is caused by vestibulitis and vaginismus sex, but in some cases, it can be caused by cancer or other reproductive diseases.
* Pain in the abdomen
There are many reproductive diseases that can cause pain in the pelvis, such as appendicitis, salpingitis, uterine descensus,.. but it can be caused by the early stage of endometrial cancer.
* Swelling or lump in the pelvis
Swelling can be caused by inflammation of sexually transmitted viruses or infection by bacteria. The lump may be caused by abnormal cell growth of the uterine lining or reproductive tissue.
*Anemia
Anemia may be caused by chronic loss of blood due to prolonged or heavy abnormal menstrual bleeding.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential ingredient for the treatment of endometrial cancer, researchers examined the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (ECd ) of curcumin isolated from turmeric.
According to the assays carried out in EC cell lines,
*In vitro, curcumin inhibited EC cell migration and invasion.
* Curcumin treatment for 24 hours, decreased the expression levels of matrix metalloproteinase (MMP)-2 and -9 associated with cancer cell proliferation and survival.
* Furthermore curcumin for 24 hours of treatment also inhibited the protease activities associated with metastatic potential in EC cell lines.
* Curcumin treatment exerted anti-metastatic effects by blocking the overexpression of pathways involved in cancer cell growth.
* Moreover, combined with chemo drug ERK inhibitor U0126, curcumin works synergistically against enzymes associated with tumor proliferation, particularly, in the inhibition of the invasive capabilities of HEC-1B cells.
More precisely, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 associated with tumors proliferation via the suppression of the ERK signaling pathway in stimulating cancer cell growth.
Based on the findings and after taking other factors into account, Dr. QIAN CHEN, the lead scientist wrote in the final report, "Curcumin is a potential therapeutic agent for EC".
Taken altogether, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of endometrial cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin suppresses migration and invasion of human endometrial carcinoma cells by QIAN CHEN,1,* QING GAO,1 KUNLUN CHEN,1 YIDONG WANG,1 LIJUAN CHEN,1 and XU LI. (PMC)
(2)
Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
Cancer is a group of chronic diseases characterized by cell growth disorderly and uncontrollably in the body tissue of a specific organ.
Over time, after growing in size through unlimited division, the tumor can spread to other tissues and organs in the body via lymph or blood.
Endometrium, the inner lining of women's uterus is very susceptible to hormone change, particularly in the stages of the menstrual cycle.
Endometrial cancer is a late adulthood cancer that starts in the cells on the surface of the endometrial inner lining of the uterus caused by the alternation of the cell's DNA. Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
In the US, according to statistics, the average age of women diagnosed with endometrial cancer is 60. Endometrial cancer is more common in white women, but black women diagnosed with endometrial cancer are more likely to die from it.
There are more than 600,000 women endometrial cancer survivors in the US today. In 2019, approximately 61,880 new cases of cancer in the uterus (uterine body or corpus) will be diagnosed and this cancer will cause the death of 12,160 women.
Accompanied by the general symptoms shared by other types of cancer, the most common symptoms of endometrial cancer are
* Abnormal vaginal bleeding
Vaginal bleeding during the period with inappropriate amounts of blood flow should be checked with the doctor as soon as possible. The symptom may be caused by the expansion of overgrowth of pre-cancer uterine lining cells due to infection or breaking off the endometrial capillaries or blood vessels.
* Increase the amount of vaginal discharge
An increase in the amount of vaginal discharge accompanied by abnormal odor or pain, itching, or burning sensation may be caused by infection or inflammation.
* Painful urination
Painful urination, most of the time is caused by infection of the urinary tract that affects the bladder in emptying, but sometimes it can be caused by infectious diseases.
* Pain during sex
Painful during Most of the time is caused by vestibulitis and vaginismus sex, but in some cases, it can be caused by cancer or other reproductive diseases.
* Pain in the abdomen
There are many reproductive diseases that can cause pain in the pelvis, such as appendicitis, salpingitis, uterine descensus,.. but it can be caused by the early stage of endometrial cancer.
* Swelling or lump in the pelvis
Swelling can be caused by inflammation of sexually transmitted viruses or infection by bacteria. The lump may be caused by abnormal cell growth of the uterine lining or reproductive tissue.
*Anemia
Anemia may be caused by chronic loss of blood due to prolonged or heavy abnormal menstrual bleeding.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential ingredient for the treatment of endometrial cancer, researchers examined the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (ECd ) of curcumin isolated from turmeric.
According to the assays carried out in EC cell lines,
*In vitro, curcumin inhibited EC cell migration and invasion.
* Curcumin treatment for 24 hours, decreased the expression levels of matrix metalloproteinase (MMP)-2 and -9 associated with cancer cell proliferation and survival.
* Furthermore curcumin for 24 hours of treatment also inhibited the protease activities associated with metastatic potential in EC cell lines.
* Curcumin treatment exerted anti-metastatic effects by blocking the overexpression of pathways involved in cancer cell growth.
* Moreover, combined with chemo drug ERK inhibitor U0126, curcumin works synergistically against enzymes associated with tumor proliferation, particularly, in the inhibition of the invasive capabilities of HEC-1B cells.
More precisely, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 associated with tumors proliferation via the suppression of the ERK signaling pathway in stimulating cancer cell growth.
Based on the findings and after taking other factors into account, Dr. QIAN CHEN, the lead scientist wrote in the final report, "Curcumin is a potential therapeutic agent for EC".
Taken altogether, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of endometrial cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin suppresses migration and invasion of human endometrial carcinoma cells by QIAN CHEN,1,* QING GAO,1 KUNLUN CHEN,1 YIDONG WANG,1 LIJUAN CHEN,1 and XU LI. (PMC)
(2)
Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
#Herbal #Ashwagandha Inhibits the Risk of #Diabetes by Protecting the Beta Cells of Pancreas and Increasing thr Antioxidant Activity, Researchers Show
Kyle J. Norton
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.
In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.
There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.
* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.
In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.
However, omen with gestation diabetes is associated with a substantial risk of diabetes developing sometimes in the future.
Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.
Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes.
" risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".
"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.
The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.
According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).
However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.
Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.
Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.
In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.
Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".
Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.
In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.
There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.
* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.
In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.
However, omen with gestation diabetes is associated with a substantial risk of diabetes developing sometimes in the future.
Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.
Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes.
" risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".
"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.
The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.
According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).
However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.
Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.
Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.
In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.
Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".
Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ
#WhiteCabbage #Essentialoil (EO) Inhibits Oxidativestress Against Liver Injury, According to Studies
Kyle J. Norton
The liver is the largest internal organ in the human body, and plays an essential role in filtering blood from the intestine before passing it to other parts of the body.
The organ also produces cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones, and vitamins.
Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.
Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of the injury may be necessary.
According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.
Other most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain swelling, and tenderness.
The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.
Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.
The most common cause of liver injury is an overdose of medicine which has been found to be the number 1 factor.
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In finding a natural whole for the improvement of liver diseases, researchers examined the hepatoprotective properties of the essential oil (EO) from white cabbage.
In acute carbon tetrachloride (CT)-induced liver damage,
* Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 ± 4.92% and dimethyl disulfidefood (DMDS) 19.29 ± 2.16% as major constituents.
* Bocfal EO and DMTS were found to be potent TBARS, a byproduct of lipid peroxidation inhibitors with IC50 values of 0.51 and 3 mg/L, respectively.
* Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se.
Based on the findings, researchers said, "The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used".
Taken altogether, cabbage process anti-liver injury, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil by Morales-López J1, Centeno-Álvarez M2, Nieto-Camacho A3, López MG4, Pérez-Hernández E5, Pérez-Hernández N1, Fernández-Martínez E. (PubMed).
The liver is the largest internal organ in the human body, and plays an essential role in filtering blood from the intestine before passing it to other parts of the body.
The organ also produces cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones, and vitamins.
Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.
Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of the injury may be necessary.
According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.
Other most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain swelling, and tenderness.
The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.
Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.
The most common cause of liver injury is an overdose of medicine which has been found to be the number 1 factor.
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In finding a natural whole for the improvement of liver diseases, researchers examined the hepatoprotective properties of the essential oil (EO) from white cabbage.
In acute carbon tetrachloride (CT)-induced liver damage,
* Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 ± 4.92% and dimethyl disulfidefood (DMDS) 19.29 ± 2.16% as major constituents.
* Bocfal EO and DMTS were found to be potent TBARS, a byproduct of lipid peroxidation inhibitors with IC50 values of 0.51 and 3 mg/L, respectively.
* Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se.
Based on the findings, researchers said, "The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used".
Taken altogether, cabbage process anti-liver injury, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil by Morales-López J1, Centeno-Álvarez M2, Nieto-Camacho A3, López MG4, Pérez-Hernández E5, Pérez-Hernández N1, Fernández-Martínez E. (PubMed).
Subscribe to:
Posts (Atom)