#GreenTea #EGCG Modulates the Expression of 6-OHDA induced Neurotoxicity to Cause Parkinson's disease, Researchers Say

Kyle J. Norton

Green tea may be considered as a functional food and iron chelator in reducing the risk and progression of Parkinson's disease, some scientists suggested.

Iron chelation therapy is a primary and standard treatment for patients with iron overload.

Green tea is a precious drink with process number of health benefits known to almost everyone in Asia and the Western world.

Parkinson's disease (PD) is a progressive neurodegenerative disease, that causes severe depletion of glutamatergic and dopaminergic inputs in the striatum.

Investigation of the green tea EGCG effect on risk and progression of PD has been found to associate with many mechanisms involved in a number of aspects.

Application of metal chelation was found to ameliorate the expression of ROS in the induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, the main leading causes to the onset of PD.

In iron abnormality PD subjects, oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxy phenethylamine (6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to overexpression of the iron induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.

Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron-dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.


Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2) in regulated the RNA level, between the transcription and the translation of the gene in the expression of the iron homeostasis.


Indeed, In the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis has been shown to increase oxidative stress in damage to neuron cells, green extract GECG effects demonstrated significant inhibition of free radical and iron-free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation; heme oxygenase-1(HO-1) in increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor-gamma (PPARγ) in regulated production of pro and anti-inflammatory cytokines and cytokines.

By reducing the overexpression of oxidative damage to neuron cells through regulation of iron-related factors as mentioned above, iron chelator EGCG can counteract these adverse effects and prevent the onset of PD.

Further study of the mechanism of disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expressions, such as DMT1 with function in the mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.

Dysregulation of hepcidin production results in a variety of iron disorders.

Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea GECG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.


Interestingly, there was a report suggested that the intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.

The evidence revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as an iron chelator in the regulation of PD progression.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin, and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease by Bitu Pinto N1, da Silva Alexandre B2, Neves KR3, Silva AH3, Leal LK3, Viana GS1.(PubMed)
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by Iowa State University

#Aloe-Emodin Fopund in #Herbal #Aloevera Modulates Proteins and Genes Associated with #LungCancer Cell Apoptosis, Researchers Say

Kyle J. Norton

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wounds, burn healing, minor skin infections, sebaceous cysts, diabetes, elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In the Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistics.


Aloe-emodin has been studied extensively through our scientific community for its effects against cancer including the study of induced apoptosis in lung carcinoma cell lines CH27 (human lung squamous carcinoma cell) by breaking of DNA strands (DNA ladders and sub-G(1) formation) and regulating of the expression of Bcl-2 family proteins (a suppressor of apoptosis). In the study of the effects of aloe-emodin-induced cell death in the human lung nonsmall cell carcinoma cell line H460, aloe-emodin was involved regulating apoptotic cell death through the class of mitogen-activated protein kinases(p38). These results suggested that aloe-emodin found in ALOE VERA may be a potential agent for preventing and treating lung cancer.


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References
(1) Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
Lee HZ, Hsu SL, Liu MC, Wu CH.(PubMed)
(2) Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. by Yeh FT, Wu CH, Lee HZ(PubMed)

#DriedPeas and #BeanFibers inhibit Parameters Associated with the Onset of #MetabolicSyndrome, Researchers Show

Kyle J. Norton

Intake of dried peas fiber daily and regularly may reduce the risk of metabolic syndrome, some institute studies suggested.

Metabolic syndrome is a biochemical and physiological factor associated with the risk of cardiovascular disease and type 2 diabetes.
The dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with a healthy source of proteins, fibers, vitamins, and minerals.

In the study to investigate the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans, and lentils), compared with counseling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the MetSyn of in 2 groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults, researchers after adjusting to many confounders after 8 weeks of experiment suggested that
1. Pulse group expressed an HDL and C-peptide increased by 4·5 and 12·3 %, respectively compared to a decrease by 0·8 and 7·6 %, respectively, in the energy-restricted group.
2. Insulin AUC decreased in both females and males on the energy-restricted diet by 24·2 and 4·8 %, respectively, and on the pulse diet, it decreased by 13·9 % in females and 27·3 % in males respectively.

Based on the result interpretation, Dr. Mollard RC, the lead author said," Frequent consumption of pulses in an ad libitum diet reduced risk factors of the MetSyn".

C-peptide is a substance produced by the beta cells in the pancreas with the function to connects insulin's A-chain to its B-chain in the insulin molecule.

Insulin AUC is the area under the curve in a 2 dimension coordinate used to measure the insulin concentration in blood insulin vs. time.



Unfortunately, the method used to calculate AUC may affect the interpretation of whether or not an intervention was effective, according to some researchers.

In support of the above study, the Fahan University of Medical Sciences conducted a cross-sectional study of 425 subjects 35 to 55 y of age, using a food-frequency questionnaire. including in the report of blood pressure, waist circumference, glucose, triacylglycerols, and high-density lipoprotein cholesterol to measure the risk of the metabolic syndrome defined based on Adult Treatment Panel III guidelines, after examining the returned questionnaire, researchers found that daily intake of these groups of the population can be classified into 5 patterns, namely,

1. A Western pattern (high in sweets, butter, soda, mayonnaise, sugar, cookies, the tail of a lamb, hydrogenated fat, and eggs)
2. A prudent pattern (high in fish, peas, honey, nuts, juice, dry fruits, vegetable oil, liver and organic meat, and coconuts and low in hydrogenated fat and non-leafy vegetables)
3. A vegetarian pattern (high in potatoes, legumes, fruits rich in vitamin C, rice, green leafy vegetables, and fruits rich in vitamin A),
4. A high-fat dairy pattern (high in high-fat yogurt and high-fat milk and low in low-fat yogurt, peas, and bread),
5. A chicken and plant pattern (high in chicken, fruits rich in vitamin A, green leafy vegetables, and mayonnaise and low in beef, liver, and organic meat)

And in comparison to all 5 groups
1. The western pattern was associated with greater odds of having increased triacylglycerol and blood pressure
2. The prudent pattern was positively associated with a prevalence of low high-density lipoprotein cholesterol levels
3. The vegetarian dietary pattern was inversely associated with a risk of an abnormal fasting blood glucose level

Adult Treatment Panel III guideline is used as a classification of LDL, Total, and HDL Cholesterol (mg/dL).

Dr. Amini M, the lead author emphasized, " Major dietary patterns were significantly associated with the risk of metabolic syndrome".

In other words, there is no specific diet pattern that can be considered a daily diet in reducing the risk of metabolic syndrome. A mix of ingredients of the above diet selectively may be necessary for people who are at higher risk of such syndrome

Interestingly, in the study to develop baked and extruded functional foods from Metabolic Syndrome (MS) specifically designed ingredient mixes with optimum amino acid makeup using key food ingredients with functional properties such as whole cereals, legumes, skimmed milk powder, along with flaxseeds and fenugreek seeds, researchers after taking into account of other confounders suggested that six ingredient mixes from above of bread and four ingredient mixes each of extruded snack and noodles showed a specifically designed for MS patients who had significantly (p ≤ 0.05) higher lysine, crude protein, ash and fiber and low carbohydrates in compare control whole wheat flour products, hence appropriate for MS patients.

Taken together, dried peas and bean fibers may be used conjunction in with a vegetarian diet to provide a strong impact in ameliorated risk and treatment of the metabolic syndrome.


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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults by Mollard RC1, Luhovyy BL, Panahi S, Nunez M, Hanley A, Anderson GH.(PubMed)
(2) Development of baked and extruded functional foods from metabolic syndrome specific ingredient mix by Miglani N1, Bains K1, Kaur H1.(PubMed)
(3) Relationship between major dietary patterns and metabolic syndrome among individuals with impaired glucose tolerance.
Amini M1, Esmaillzadeh A, Shafaeizadeh S, Behrooz J, Zare M.

#GreenTea, Bioactive Epigallocatechin-3-O-(3-O-methyl) Gallate (EGCG3"Me)Enhances the Immune Function Against the Allergic Initiation, Researchers Say

Kyle J. Norton

Green tea may have a particular and special effect in ameliorating autoimmunity in the precipitation of allergic diseases, some scientists opinionated.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Allergic diseases are a class of conditions characterized by an overreaction of the immune system to substances that cause little or no harm to the body.

Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate with certain mechanisms.

According to the Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibiting the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in the expression of immunoglobulin E (IgE), an antibody isotype involved in allergy disorder through 67 kDa laminin receptor in the mediation of the suppressive effect by epigallocatechin-3-O-gallate.

Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cells by suppressing the myosin light chain phosphorylation in the regulated immune response to eosinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signaling by modulation of inflammatory cytokines expression.


In a double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed significantly relieving allergic symptoms induced by pollen such as nose blowing, and eye itching compared with the placebo group without affecting the In normal immune responses.

More interestingly, in mouse bone marrow-derived mast cells activated by antigens, bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell-signaling protein (cytokine) in response to systemic inflammation in the acute phase infection. and macrophage Inflammatory Proteins(MIP-1α), a chemokine-involved host response to invading bacteria and viruses.

Compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited much stronger anti-allergic activity than 43.5 mg of EGCG, observed by the area under the curve AUC (area under the drug concentration-time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.

Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered a functional food for protection against autoimmune response stimulated by unharmful allergens.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or life style-related diseases by Maeda-Yamamoto M1.(PubMed)(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)

#Garlic Phytocompounds Poccess Anticancer Activity, According to Studies

Kyle J. Norton

Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu, blood pressure cholesterol levels, natural antibiotics, etc. but Garlic appears to be generally safe although allergic reactions may occur.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues. Sometimes cancer cells spread to other organs in the body via lymph or blood and results may be in death.

A recent study led by author Dr. Oommen S indicated that allicin, the main ingredient found in garlic induced the formation of apoptotic bodies, nuclear condensation, and a typical DNA ladder in cancer cells, causing cell death.

Researchers in the study of ingredient allicin also showed that the phytochemical was capable of inducing an increase in the rate of apoptosis by affecting the expression of the cell cycle division and negation of pro-inflammation.


In cancer HL60 and U937 cell lines, allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway by involving the activation of the mitochondrial apoptotic pathway by GSH depletion and by changes in the intracellular redox status.

In the research of the function of 20 compounds from garlic, researchers at the Kerala Agricultural University, Kerala, suggested that garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers.


Other compounds found in garlic such as organosulfur, its extract, and phytocompounds also suppress cancer cell proliferation and induced cell cycle arrest.

Therefore, people with or without cancers may consider adding a portion of garlic whole food into their diet for the prevention, management, and treatment of the disease.


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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells by Oommen S1, Anto RJ, Srinivas G, Karunagaran D.(PubMed)
(2) Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA by Park SY1, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S.(PubMed)
(3) Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells by Miron T1, Wilchek M, Sharp A, Nakagawa Y, Naoi M, Nozawa Y, Akao Y.(PubMed)
(4) Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study by Roy N1, Davis S, Narayanankutty A, Nazeem P, Babu T, Abida P, Valsala P, Raghavamenon AC. (PubMed)
(5) Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice by Jiang X1, Zhu X1, Huang W1, Xu H1, Zhao Z2, Li S1, Li S3, Cai J3, Cao J3. (PubMed)
(6) Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis by Kim WT1, Seo SP2, Byun YJ1, Kang HW1, Kim YJ1, Lee SC1, Jeong P1, Seo Y3, Choe SY3, Kim DJ4, Kim SK5, Moon SK6, Choi YH7, Lee GT8, Kim IY8, Yun SJ1, Kim WJ1.(PubMed)
(7) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC3.(PubMed)

#Andrographis Inhibits Parameters Associated with the Onset of #NeurodegenerativeDiseases including #Alzheimer's disease AD, Researchers Say

Kyle J. Norton

The good news for aging people with neurodegenerative diseases, Andrographis paniculata possesses potent anti-inflammatory activity in the expression of neurodegeneration a study by a renowned institute suggested.
Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,......

Andrographolide, a major phytochemical isolated from Andrographis paniculata, exerted significant anti-neuro deficits in reduced infarct volume with a maximum reduction of approximately 50% at a dose of 0.1 mg·kg(-1).


According to the National University of Singapore, the efficacy of the chemical compound in neuroprotective effects is the result of the suppression of NF-κB, a protein in regulated cell survival and function of microglia in the activated response to brain injuries and immunological stimuli together with the reduction in the production of inflammatory cytokines.

Dr. Chan SJ, the lead research said, "Andrographolide, given i.p. 1 h after pMCAO, reduced infarct volume with a maximum reduction of approximately 50% obtained at 0.1 mg·kg(-1)".

Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. the progression of AD in these animals is associated with aging on the loss of cognitive function, causing a decrease in the synaptic functions and an increase in the main hallmarks of Alzheimer's disease (AD).

Natural product (Andrographolide, ANDRO), administered to aged degus (56-month old) for 3 months, in compared 2 control groups (young degus: 12-month old and aged degus: 56-month old), showed a recovery of spatial memory and learning performance, synaptic basal transmission; and enhancing the neuroprotective effect, through reduced phosphorylated tau protein and reduced amyloid beta aggregate maturation in involving neurodegeneration in Alzheimer's disease (AD) in Andrographolide, ANDRO treated subjects.

Taken together, Andrographis could be used as a functional food in potential therapy for AD-associated neural damage due to aging processes and neuropathological hallmarks of aging-related diseases such as AD.



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Holistic System In Existence That Will Show You How To
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Sources
(1) Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischemia by Chan SJ1, Wong WS, Wong PT, Bian JS(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)

#Herbal Turmeric's #Curcumin Decreases Levels of #Hyperlipidemia by Reducing Body Weight, Liver Weight, and Adipose Weight, Researchers say

Kyle J. Norton

Hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.
The condition is normally known as high blood cholesterol in the general population.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

Believe it or not, about half of the U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol.

There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.

Some researchers suggested the promotion of a high-fat diet over the past decades may be one of the silent causes of hyperlipidemia in the Western world.

Dr. Charles Desmarchelier in the examined the risk of high blood cholesterol in a high-fat diet model said, "Mice on Western diet showed increased plasma cholesterol levels, associated with the higher dietary cholesterol supply, yet, significantly reduced cholesterol levels were found in intestine and liver".

And, "(The) intestine and liver react to a high dietary fat intake by activation of de novo cholesterol synthesis and other cholesterol-saving mechanisms, as well as with major changes in phospholipid metabolism, to accommodate to the fat load'.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as antioxidant, hypoglycemic, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural ingredient for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.

The study included 40 male Wistar rats divided into four groups with 10 rats in each. Two groups were fed with a standard rodent diet and the other two with a 60% high-fructose diet for 10 weeks. Curcumin (200 mg/kg body weight) was administered along with the diets simultaneously to each of the aforementioned diet groups.

After 10 weeks of the experiment, researchers found that curcumin decreased the levels of hyperlipidemia observed by reducing body weight, liver weight, and adipose weight.

The plasma levels of triglyceride inhibited the proteins associated with fat cell fat metabolism, and lipid ratios, and increased HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats were also lower by the injection of curcumin.

Furthermore, curcumin also suppressed the lipogenic enzymes involved in regulating lipogenesis in fat cells.

Taken altogether, turmeric processed with a high amount of curcumin may be used for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals by Kocher A1, Bohnert L1, Schiborr C1, Frank J, (PubMed)
(3) C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia by Charles Desmarchelier,1 Christoph Dahlhoff,1,2 Sylvia Keller,3 Manuela Sailer,1Gerhard Jahreis,3 and Hannelore Daniel. (PMC)