Friday, 18 August 2023

Aged Garlic Extract (AGE) processes Anti #Hypertension Activity, Researchers Say

Kyle J. Norton

Garlic may be used as a chemopreventive and treatment agent against hypertension. In hypertension of 80-90% of patients with excess glucocorticoid levels, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.


Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to your lifestyle, maintaining an ideal weight, and dieting with low salt, you could do just fine without the drugs.


In adult men and women, who participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), the intake of garlic is associated to reduce the risk of hypertension by up to 26%.


In support of the above, a randomized, placebo-controlled, clinical trial conducted on 56 CAD patients, aged 25 - 75 years old also suggested that treatment with garlic-based drugs can be an effective treatment for controlling BP in CAD patients and has no interaction with other drugs that CAD patients take, after 3 months of administration.


Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, "Aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"

In fact, in Traditional Chinese Medicine, Food Therapy, and Hypertension Control, garlic is the food recommended to be used to facilitate hypertension control. Based on a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.

Taking all together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that the garlic anti-hypertension effect may result from its anticoagulant property.


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Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3.(PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)

#Cucumber Protects the Stomach by by Restoring the Natural Gastric Balance and Function, According to Studies

Kyle J. Norton


A stomach ulcer is an open sore in the lining of the stomach.

In other words, if the mucus layer of your stomach that protects your stomach tissues against stomach acid is worn away and stops functioning, you may have a stomach ulcer.

The most common symptoms of stomach ulcer are indigestion caused by reduced function of the stomach and pain or discomfort in the stomach area.

Some patients may also experience symptoms of heartburn, vomiting, or vomiting blood, leading to dark blood in stools, or stools that are black or tarry, unexplained weight loss, and appetite changes.

If you have some of the aforementioned symptoms that often change over time, please check with your doctor to rule out the possibility.

Epidemiologically, long-term intake of NSAIDs, smoking, excessive alcohol drinking psychological symptoms such as stress, and eating spicy food are some of the most stomach ulcer prevalent factors.

According to the statistics, in the US, peptic ulcer disease (PUD) affects approximately 4.5 million people annually and the lifetime prevalence infected by H pylori is approximately 20%.

Believe it or not, approximately, 1/10 people in the US will develop an ulcer in the stomach or small intestine at some point in their lives.

Conventionally, depending on the causes of the stomach ulcer, the patient may be prescribed by
* Antibiotic medications for the treatment of bacterial infection.

* Medications that reduce or block acid production and promote healing.

* Particularly, the medications that protect the lining of the stomach.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound for the treatment of stomach ulcers, researchers compared the compares the antacid effect of broccoli, kale, radish, cucumber, lemon juice, cold milk, and curd in an artificial stomach model.


According to the tested results, cucumber exerted an acid-neutralizing effect better than those of water.

Compared to other healthy foods, cucumber exhibited a significantly higher duration of consistent neutralization.

In other words, cucumber protected the stomach against acidity by restoring the natural gastric balance and function, which may have a strong impact on curbing acid reflux and reducing the burning sensation due to hyperacidity.

Through its acid-neutralizing effect, cucumber may soothe the inflamed mucosa of the stomach against the onset of an ulcer.
Based on the results, Dr. after taking other factors into account wrote, "It may be concluded that the natural food ingredients used in this study exhibited significant antacid activity, justifying their use as essential dietary components to counter hyperacidity".

Taken together, cucumber may be used for the treatment of stomach hyperacidity, pending the confirmation of the larger sample size and multicenter human study.

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A comparative study of the antacid effect of some commonly consumed foods for hyper acidity in an artificial stomach model by Panda V1, Shinde P2, Deora J2, Gupta P. (PubMed)

#Beets Exhibit Hepatoprotective Effects through Anti Liver Toxicity Activity, Researchers Say

Kyle J. Norton

Beet may be considered as a functional food to protect the liver against any forming of liver disorders a renowned institute proposed.

Liver diseases are a class of diseases characterized by the disordered function of the liver, including cirrhosis, hepatitis, hepatitis B, hepatitis C, nonalcoholic liver disease, non-infectious liver diseases, benign liver tumors, liver cancer,......


Beet, best known as beetroot or garden beet, belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to Dr. Hari Singh Gour Vishwavidyalaya, Beta vulgaris Linn. (BV, Chenopodiaceae) leaves extract showed a significant effect in protecting the liver against hepatoxicity, measured by levels of serum markers enzymes together with antioxidants.

In vitro studies, n-butanol fraction of BV leaves (BVBF) isolated from beet, at doses of 50, 100, and 200 mg/kg exhibited liver protective action against ethanol-induced hepatic toxicity by the restoration of biochemical changes in liver tissues.

Furthermore, in carbon tetrachloride (CCl(4))-induced liver toxicity injured rats, orally administrated ethanolic extract of Beta vulgaris roots exerted a profound hepatoprotective activity at doses of 1000, 2000, and 4000 mg/kg.

Moreover, in the finding of new phytochemicals isolated from beetroot, researchers found that vitexin 7-O-beta-D-glucopyranoside (3), and vitexin 2''-O-beta-D-glucopyranoside, the new compounds also exhibited hepatoprotective effect at rates of 65.8 and 56.1%, respectively in rat induced liver toxicity model.

More importantly, others' newly differentiated flavonoids, 2",2"'-di-O-α-rhamnopyranosyl-vicenin II, a di-C-glycosyl flavone, and herbacetin 3-O-β-xylopyranosyl- (1"' --> 2")-O-β-glucopyranoside extracted from leaves of beet, once again demonstrated hepatoprotective effects in the intoxicated rat by the administration of acetaminophen.

Additionally, the newly acquired compounds above also demonstrated hypolipidemic activity in reduced risk of liver diseases in rats with a high-fat diet.

Taken together, beet is a potent functional food with plenty of liver-protective phytochemicals used for the prevention and treatment of liver disease.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
Source
(1) Protective role of Beta vulgaris L. leaves extract and fractions on ethanol-mediated hepatic toxicity by Jain NK1, Singhai AK.(PubMed)
(2) Hepatoprotective activity of Beta vulgaris against CCl4-induced hepatic injury in rats by Agarwal M1, Srivastava VK, Saxena KK, Kumar A.(PubMed)
(3) Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts of Beta vulgaris var. cicla by Kim I1, Chin YW, Lim SW, Kim YC, Kim J.(PubMed)

Xixian Tongshuan Preparation Including #Herbal #Angelica Processes Neuro-Protective Activity through Its Anti Inflammatory Effects

Kyle J. Norton

Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.

In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.

Brain ischemia is a condition caused by insufficient blood flow to the brain to meet metabolic demand, leading to irreversible brain damage in severe cases.

In other words, brain ischemia induced the death of neurons of the affected tissues.

Brain ischemia can be classified into
* Focal ischemia is a condition caused by damage to a specific region of the brain; and

* Global ischemia is a condition of damage that affects the wide areas of brain tissue, leading to symptoms of impairments in vision, body movement, and speaking.

Dr. Jin-Moo Lee in the study of the issues of how the brain tissue responds to ischemia, said, "The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells".

And, "...the brain’s intrinsic cell-cell and intracellular signaling mechanisms, normally responsible for information processing, become harmful under ischemic conditions, hastening energy failure and enhancing the final pathways underlying ischemic cell death in all tissues, including free radical production, activation of catabolic enzymes, membrane failure, apoptosis, and inflammation".


Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

In finding a potential compound for the protection of the brain, researchers examined the neuroprotective effects of Xixian Tongshuan Preparation containing Ligusticum chuanxiong, Angelica Sinensis, Carthamus tinctorius, and Panax pseudo-ginseng.

According to chemical analysis, all constituents found in the formula work synergistically to protect the neurons against damage.

Furthermore, the formula inhibited the 5 glutamate receptors, TGFR-1, and VEGFR-2 in the mediation of the production of pro-inflammatory cytokines to induce neuron death and injury.

Moreover, a single component, such as neo-complanatoside and neo-carthamin, in Xixian Tongshuan Preparation could simultaneously act on different targets to exert their neuroprotective effects.

Based on the findings, researchers wrote, "This study explains the multi-target mechanism of anti-cerebral ischemic injury in neuroprotection at the molecular level, and provides a certain direction for the clinical application and experimental research of Xixian Tongshuan Preparation".

Taken together, herbal Angelica in combination with other herbal medicines may be considered a neuroprotective remedy, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
,
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Multi-target neuroprotective effect of Xixian Tongshuan Preparation against cerebral ischemia injury].[Article in Chinese] by Gu Y1, Zhao BW1, Chen X1, Luo YZ1, Zhang YL. (PubMed)
(2) Brain tissue responses to ischemia by Jin-Moo Lee, Margaret C. Grabb, Gregory J. Zipfel, and Dennis W. Choi. (PMC)

#Allyl‐isothiocyanate (AITC) Vapor Produced from Pure #Sinigrin Processes Anti Fungal Infection Activity, Researchers Suggest

Kyle J. Norton

A fungus is a primitive organism, including mushrooms, mold, and mildew found in the air, in the soil, on plants, and in water.
Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause a fungal infection that often starts in the lungs or on the skin.

People with a weakened immune system are more likely to be infected by fungi, including the fungus Aspergillus which causes lung infection.

Similar to other bacteria, there are millions of different fungal species on Earth, but only about 300 are known to infect people.

Conventionally, fungal infection is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.


If you are currently taking antibiotics for the treatment of fungal infection, please make sure that you know all possible side effects for preventive measures.

The most common symptoms of skin fungal infection are red and cracking or peeling skin accompanied by itching, depending on the location of the affected skin.


In a serious case of fungal lung infection, accumulated fungus fibers, blood clots, and white blood cells may appear in the lungs or sinuses, leading to coughing up blood or fever, chest pain, and difficulty breathing, depending on the size of the accumulation.

In seeking a natural compound for the treatment of fungal infection, researchers analyzed the antifungal infection of the roots of twelve plant spades from bath mycotrophic (hosts of YAM fungi) and non‐mycotropic (non‐hosts) families against the fungus Cladosporium cucumerimun Ellis & Arch.

2 species from the Brassicaceae such as Chenopodiaceae (Spinacea oleracea L., Beta vulgaris L.) showed a significant effect on fungus compared to Brassica kaber (DC.) Wheeler, Brassica napus L., Brassica campestris L., Thlaspi arvense L., Raphanus raphasnistrum L. which showed limited activity.

According to the TLC bioassay, Chloroform extracts of B. Kaber roots appeared to have the greatest quantity of extractable antifungal compounds.

Three antifungal compounds in chloroform extracts from B. Kaber roots were shown to be derived from glucosinolates, containing a high amount of sinigrin.


The finding strongly supports the use of sinigrin for the treatment of fungal infections.

Furthermore, in the differentiation of the fungitoxicity of allyl‐isothiocyanate (AITC) vapor produced from pure sinigrin against Penicillium expansum, the causal agent of blue mold on pears, 5 mg L−1 AITC‐enriched atmosphere showed the best control of blue mold by exposing fruits for 24 h.

At 1 × 103 conidia mL−1to almost 80% at 1 × 106 conidia mL−1, AITC decreased the percentage of infected wounds, compared to >98% of wounds infected in untreated fruits.

Moreover, AITC treatments were effective up to 24 h after inoculation for Conference and 48 h for Kaiser. AITC treatments also controlled a thiabendazole‐resistant strain of P. expansum, reducing the incidence of the blue mold by 90% in both cultivars.


Dr. M. Mari, at the end of the experiment, wrote, "The use of AITC produced from pure sinigrin or from Brassica junceadefatted meal may be an economically viable alternative to synthetic fungicides against P. expansum".

Taken together, sinigrin may be considered a supplement for the prevention and treatment of fungal infection, pending the confirmation of a large sample size and multicenter human study.

However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)

#Sulforaphane (SFN) and Broccoli Sprout #Extract (BSE)Significantly Prevent Diabetes-induced Cardiac Dysfunction, Hypertrophy, and Fibrosis, According to Studies

Kyle J. Norton

Diabetes is a medical condition characterized by the failure of the body to utilize the insulin in converting glucose to energy, leading to high levels of glucose in the bloodstream.

Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor site clogged-up by fat and cholesterol.

Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.

The most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk of developing microvascular and macrovascular complications. includes cardiovascular disease.

Diabetic cardiomyopathy is a complication of the heart muscle in people with diabetes, leading to heart failure that causes the reduced function of the heart to circulate blood through the body.
The most common symptoms of diabetic cardiomyopathy are the accumulation of fluid in the lungs or legs.

Dr. Adeghate E, in the examination of the diabetic cardiomyopathy associated with the structural changes in the myocardium of diabetes, wrote, " If left unmanaged, DM can lead to numerous long-term complications including micro- and macro-angiopathy and heart failure (HF)".

And, "Most diabetics usually die as a result of HF resulting from diabetes-induced coronary artery disease and cardiomyopathy. Coronary artery disease and cardiomyopathy are normally preceded by hyperglycemia (HG)".


In other words, management diabetes by preventing the onset of hyperglycemia is the most effective way to reduce the risk of diabetic cardiomyopathy in diabetes.


More precisely, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.


With an aim to find a natural food for the prevention and treatment of diabetic cardiomyopathy, researchers examined the effect of broccoli sprout extract in an animal model.

The study included male db/db and age-matched wild-type (WT) mice given sulforaphane (SFN, an Nrf2 activator) and its natural source, broccoli sprout extract (BSE) by gavage every other day for 3 months, including vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high dose (estimated SFN availability at 1.0 mg/kg), and SFN (0.5 mg/kg).

According to the results of echocardiography and histopathological analysis, both BSE and SFN showed significant prevention of diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis.

Furthermore, BSE, like SFN, significantly exhibited the Nrf2 transcriptional activity associated with the protective effect of oxidative damage triggered by injury and inflammation.

In other words, stimulating the Nrf2 function of the protein, BSE, and SFN significantly prevented cardiac oxidative damage and inflammation.


Moreover, BSE at high doses exerted a similar effect as those of SFN. particularly, in BSE at a high dose that works synergistically with SFN to prevent DCM.

Based on the findings, researchers said, "BSE could potentially be used as a natural and safe treatment against DCM via Nrf2 activation".

Taken altogether, broccoli sprout processed abundantly SFN may be considered supplements for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice by Xu Z, Wang S, Ji H, Zhang Z, Chen J, Tan Y, Wintergerst K, Zheng Y, Sun J, Cai L. (PubMed)
(2) Structural changes in the myocardium during diabetes-induced cardiomyopathy by Adeghate E1, Singh J. (PubMed)

#Taraxasterol (TAR)Found in #Herbal #Dandelion (Taraxacum officinale) Inhibits the Proteins Associated with the Onset of of Rheumatoid Arthritis (RA)

Kyle J. Norton

Arthritis, one of the Musculoskeletal disorders (MSDs) degenerative disease, is a general term of joint inflammation, affecting over 21% of the US population.

There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacking some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many older adults.

According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

In finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from the Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA).

In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.


Furthermore, the application of TRA also inhibited the enzymes involved in the production of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, and degradation of the normal tissues.

Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.


Taken together, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)