Kyle J. Norton
Ovarian cancer is a medical and chronic condition characterized by irregular cell growth in the tissues found either at the tail ends of the fallopian tubes or the ovaries.
According to the statistics provided by the American Cancer Society, ovarian cancer is one of the deadly reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.
The lifetime risk of a woman getting ovarian cancer is 1/78 compared to the lifetime dying risk of 1/108.
The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.
The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, and acquired genetic mutation such as TP53 tumor suppressor gene are susceptible to the substantial risk of the development of the disease.
Besides sharing the common symptoms of other types of cancer, most ovarian cancer patients may experience symptoms of discomfort in the pelvic area, and changes in bowel habits, such as constipation. and a frequent need to urinate.
In seeking a natural product that processes anti-ovarian cancer properties, researchers examined the effects of 3,3'-diindolylmethane (DIM) on ovarian cancer cell viability, invasion, and sensitivity to chemotherapy.
According to the final results obtained by the ovarian cancer SKOV3 and A2780 cell lines treated by the 3,3'-diindolylmethane (DIM), DIM treatment not only potently suppressed the viabilities of ovarian cancer cells but also inhibited xenograft growth in nude mice.
Furthermore, according to the gene analysis, DIM inhibited phosphorylation of STAT3 and AKT proteins and proteins activated by STAT3 and AKT involved in cell growth and division and cell movement in the ovarian cancer SKOV3 and A2780 cell lines
Moreover, DIM inhibited the production of protein and genes associated with the production of a new blood vessel for the cancer cells to grow, promotion of cancer cell survival, and anti-apoptosis.
Additionally, in order to obtain more information about DIM anti-ovarian cancer effects, researchers examined the phytochemical activity of Interleukin (IL6) which has been found to be a major contributor to the initiation and progression of ovarian cancer.
During the experiment, human ovarian carcinoma-derived cell lines SKOV3 and A2780 treated with IL6 and/or DIM and subjected to in vitro proliferation, DIM inhibited the increase of ovarian cancer cell adhesion, migration, and invasion caused by the administration of IL-6 through deactivated the expression of protein STAT3 similar to that of the aforementioned study.
Importantly, DIM-induced ovarian cancer cells apoptosis is associated with the inhibition of the expression matrix metalloproteinases MMP-2 and MMP-9 associated with the pathologic relationship to cancer.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in vitro and in vivo by Zou M1, Xu C2, Li H3, Zhang X4, Fan W. (PubMed)
(2) IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells by Zou M1, Zhang X2, Xu C. (PubMed)
Friday, 18 August 2023
Serum of Lycopene in the Body Is Associated with a Reduced Level of Oxidativestress, According to Studies
Kyle J. Norton
Oxidative stress is characterized by overexpression of free radicals in the body.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radical readily donates or intercept an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation and comes either from dietary sources or produced by the body.
In contrast to general belief, free radical is also needed in moderated amounts for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributing to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
A total of 23 healthy postmenopausal women, 50-60 years old, were provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin, and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), and catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consuming either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation increased substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken together, tomatoes and their major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
Oxidative stress is characterized by overexpression of free radicals in the body.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radical readily donates or intercept an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation and comes either from dietary sources or produced by the body.
In contrast to general belief, free radical is also needed in moderated amounts for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributing to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
A total of 23 healthy postmenopausal women, 50-60 years old, were provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin, and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), and catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consuming either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation increased substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken together, tomatoes and their major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
Thursday, 17 August 2023
#Furanodiene Isolated from #Turmeric Processes Anti-Metastatic Activity, Scientists Suggest
Kyle J. Norton
Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.
At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including unintended weight loss, loss of appetite, fatigue, and tiredness, and gastrointestinal problems.
Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Metastasis is the process to induce the development of secondary malignant growths at a distance from primary cancer.
Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.
According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the prevention of metastasis in cancer, researchers examined the effects of Furanodiene, a bioactive compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin) on tumor metastatic activities.
According to the tested differentiation, low concentrations (5-25μM) of furanodiene inhibited adhesion, migration, and invasion of breast cancer cells, without inducing cytotoxicity, apoptosis and cell cycle arrest.
Furthermore, furanodiene also regulated the parameters such as the integrin αV expression, β-catenin expression, associated with the cell survival, migration, proliferation, differentiation, angiogenesis, and remodeling of the extracellular matrix in the modulation of the tumor metastasis process.
In MDA-MB-231 cells, furanodiene modulated the matrix metalloproteinase 9 (MMP-9) involved in tumor metastasis and cancer markers.
Based on the results Dr. Zhong Z, the lead scientist said, "furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer".
Taken together, turmeric processed with a high amount of bioactive compound furanodiene may be considered a supplement for the prevention of tumor metastasis, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro by Zhong Z1, Tan W1, Chen X2, Wang Y. (PubMed)
Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.
At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including unintended weight loss, loss of appetite, fatigue, and tiredness, and gastrointestinal problems.
Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Metastasis is the process to induce the development of secondary malignant growths at a distance from primary cancer.
Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.
According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the prevention of metastasis in cancer, researchers examined the effects of Furanodiene, a bioactive compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin) on tumor metastatic activities.
According to the tested differentiation, low concentrations (5-25μM) of furanodiene inhibited adhesion, migration, and invasion of breast cancer cells, without inducing cytotoxicity, apoptosis and cell cycle arrest.
Furthermore, furanodiene also regulated the parameters such as the integrin αV expression, β-catenin expression, associated with the cell survival, migration, proliferation, differentiation, angiogenesis, and remodeling of the extracellular matrix in the modulation of the tumor metastasis process.
In MDA-MB-231 cells, furanodiene modulated the matrix metalloproteinase 9 (MMP-9) involved in tumor metastasis and cancer markers.
Based on the results Dr. Zhong Z, the lead scientist said, "furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer".
Taken together, turmeric processed with a high amount of bioactive compound furanodiene may be considered a supplement for the prevention of tumor metastasis, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro by Zhong Z1, Tan W1, Chen X2, Wang Y. (PubMed)
#Lycopene Exerts Antioxidant Property Against the Initiation of Free Radical Chain Reaction, and Chelating Activity Against Chemical Toxins, Researchers Find
Kyle J. Norton
Natural toxins are toxic chemicals produced by living organisms with the aim to protect themselves from predators. Therefore, these types of toxins do not cause harm to the host but can be very deadly to other organisms if they are consumed.
The most common types of natural toxins produced by plants are alkaloids such as pyrrolizidine alkaloids and glycoalkaloids, cyanogenic glycosides, lectins, saponins, and antinutrients.
Chemical toxins are chemicals or substances that not only are harmful to the environment but a hazard to human health if inhaled, ingested, or absorbed through the skin.
The most common types of chemical toxins are inorganic compounds such as mercury and carbon monoxide, and organic compounds, such as methyl alcohol.
The Institute of Natural Medicine suggested that exposure to chemical and natural toxins may cause* Enzyme dysfunction, including antioxidant enzymes that prevent the free-radical damage that causes damage to protein, lipid, and cell DNA.
* Reduced mineral absorption that can induce bone disease.
* Damage to the organs, particularly in the detox organs, such as the liver and kidney
* Damage cells' DNA and modify genetic expressions of the host that initiates the onset of cancer.
* Alternation of the body's hormones by inducing, inhibiting, mimicking, and blocking hormone production.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to protect the body against environmental, occupational, and therapeutic toxins, researchers examined the lycopene anti-toxic agent's activity.
High intake of lycopene administration has been effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides.
Phytochemical carotenoids processed by abundantly bioactive compound lycopene have also been found to process antioxidative activity against long-term overexpression of free radicals, antiapoptotic activity against cancer cells, radical scavenging activity against the initiation of free radical chain reaction, and chelating activity against chemical toxins.
Furthermore, lycopene also played a critical role in the modulation of inflammatory pathways that facilitate the onset of protein, lipid, and cellular DNA damage.
Based on the results, researchers said, " This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants".
Taken together, lycopene found in carotenoids may be considered supplements for the prevention and treatment of diseases associated with chemical and natural toxins, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of lycopene against chemical and natural toxins: A review by Hedayati N1, Naeini MB2, Nezami A1, Hosseinzadeh H1,3, Wallace Hayes A4,5, Hosseini S1, Imenshahidi M1,3, Karimi G. (PubMed)
(2) How Toxins Cause Disease by The Institute of Natural Medicine
Natural toxins are toxic chemicals produced by living organisms with the aim to protect themselves from predators. Therefore, these types of toxins do not cause harm to the host but can be very deadly to other organisms if they are consumed.
The most common types of natural toxins produced by plants are alkaloids such as pyrrolizidine alkaloids and glycoalkaloids, cyanogenic glycosides, lectins, saponins, and antinutrients.
Chemical toxins are chemicals or substances that not only are harmful to the environment but a hazard to human health if inhaled, ingested, or absorbed through the skin.
The most common types of chemical toxins are inorganic compounds such as mercury and carbon monoxide, and organic compounds, such as methyl alcohol.
The Institute of Natural Medicine suggested that exposure to chemical and natural toxins may cause* Enzyme dysfunction, including antioxidant enzymes that prevent the free-radical damage that causes damage to protein, lipid, and cell DNA.
* Reduced mineral absorption that can induce bone disease.
* Damage to the organs, particularly in the detox organs, such as the liver and kidney
* Damage cells' DNA and modify genetic expressions of the host that initiates the onset of cancer.
* Alternation of the body's hormones by inducing, inhibiting, mimicking, and blocking hormone production.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to protect the body against environmental, occupational, and therapeutic toxins, researchers examined the lycopene anti-toxic agent's activity.
High intake of lycopene administration has been effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides.
Phytochemical carotenoids processed by abundantly bioactive compound lycopene have also been found to process antioxidative activity against long-term overexpression of free radicals, antiapoptotic activity against cancer cells, radical scavenging activity against the initiation of free radical chain reaction, and chelating activity against chemical toxins.
Furthermore, lycopene also played a critical role in the modulation of inflammatory pathways that facilitate the onset of protein, lipid, and cellular DNA damage.
Based on the results, researchers said, " This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants".
Taken together, lycopene found in carotenoids may be considered supplements for the prevention and treatment of diseases associated with chemical and natural toxins, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of lycopene against chemical and natural toxins: A review by Hedayati N1, Naeini MB2, Nezami A1, Hosseinzadeh H1,3, Wallace Hayes A4,5, Hosseini S1, Imenshahidi M1,3, Karimi G. (PubMed)
(2) How Toxins Cause Disease by The Institute of Natural Medicine
#CranberryJuices Inhibits Parameters and Markers Associated with the Risk of CardiovascularDisease, According to Studies
Kyle J. Norton
Cholesterol produced by the liver and from dietary sources is needed for the cell to build strong membranes, produce steroid hormone, bile acids, and vitamin D, and aid digestive functioning.
Most people with high blood cholesterol at the early do not experience any symptoms, however, as the levels of blood cholesterol continue to grow, at some points, patients may experience heart-related symptoms, including chest pain or angina, pain while walking caused by reduced blood flow to the legs.
In serious cases, elevated blood cholesterol can also induce symptoms of stroke and heart attack.
There are 2 types of blood cholesterol
* Low-density lipoprotein (LDL) also is known as “bad cholesterol”. Bad cholesterol is a major cause of plaque build-up in the arteries and a leading cause of coronary heart disease.
*High-density lipoprotein (HDL) is known as “good cholesterol”. HDL removes LDL cholesterol from your arteries back to the liver.
The healthy ratio of blood cholesterol is 4 LDL)/ 1HLD
Besides a high-fat diet, certain risk factors such as a family history of high cholesterol, being overweight or obese, physical inactivity, excessive alcohol intake, smoking and some health conditions including diabetes, kidney disease, and liver disease have been found to increase the risk of high blood cholesterol.
Epidemiological studies also suggested that a high level of blood cholesterol is associated with an increased risk of cardiovascular disease.
The endothelium is a thin membrane that lines the inside of the heart and blood vessels. The endothelium cells process an essential function in controlling vascular relaxation and contraction.
Furthermore, the endothelium cells also control enzymes associated with blood clotting, immune function, and platelet adhesion.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of prostate diseases, researchers examined the effect of chronic cranberry juice consumption on cholesterol profiles and vascular functions in an estrogen-deficient animal model.
The study included ovariectomized rats that were treated daily with commercial cranberry juice at 7 mg/kg for 8 weeks, and a dosage comparable to recent clinical studies.
According to the tested analysis, cranberry juice consumption reduced circulating levels of total cholesterol, triacylglycerols, HDL, nHDL, and nHDL/HDL ratio.
Furthermore, cranberry juice consumption improved endothelium-dependent relaxation in the aorta of ovariectomized rats by restoring p-eNOS level (endothelial nitric oxide synthase.
Overexpression of renin-angiotensin system markers (angiotensin-converting enzyme, angiotensin II, and angiotensin II type 1 receptor) associated with blood pressure was also inhibited by commercial cranberry juice.
Furthermore, commercial cranberry juice also normalizes the elevated NAD(P)H oxidase expression and oxidative stress involved in the increased levels of ROS.
Based on the findings, researchers concluded. " the novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles".
Taken together, cranberry may be considered a remedy for the prevention and treatment of cardiovascular disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats by Yung LM1, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Vanhoutte PM, Yao X, Huang Y. (PubMed)
Cholesterol produced by the liver and from dietary sources is needed for the cell to build strong membranes, produce steroid hormone, bile acids, and vitamin D, and aid digestive functioning.
Most people with high blood cholesterol at the early do not experience any symptoms, however, as the levels of blood cholesterol continue to grow, at some points, patients may experience heart-related symptoms, including chest pain or angina, pain while walking caused by reduced blood flow to the legs.
In serious cases, elevated blood cholesterol can also induce symptoms of stroke and heart attack.
There are 2 types of blood cholesterol
* Low-density lipoprotein (LDL) also is known as “bad cholesterol”. Bad cholesterol is a major cause of plaque build-up in the arteries and a leading cause of coronary heart disease.
*High-density lipoprotein (HDL) is known as “good cholesterol”. HDL removes LDL cholesterol from your arteries back to the liver.
The healthy ratio of blood cholesterol is 4 LDL)/ 1HLD
Besides a high-fat diet, certain risk factors such as a family history of high cholesterol, being overweight or obese, physical inactivity, excessive alcohol intake, smoking and some health conditions including diabetes, kidney disease, and liver disease have been found to increase the risk of high blood cholesterol.
Epidemiological studies also suggested that a high level of blood cholesterol is associated with an increased risk of cardiovascular disease.
The endothelium is a thin membrane that lines the inside of the heart and blood vessels. The endothelium cells process an essential function in controlling vascular relaxation and contraction.
Furthermore, the endothelium cells also control enzymes associated with blood clotting, immune function, and platelet adhesion.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of prostate diseases, researchers examined the effect of chronic cranberry juice consumption on cholesterol profiles and vascular functions in an estrogen-deficient animal model.
The study included ovariectomized rats that were treated daily with commercial cranberry juice at 7 mg/kg for 8 weeks, and a dosage comparable to recent clinical studies.
According to the tested analysis, cranberry juice consumption reduced circulating levels of total cholesterol, triacylglycerols, HDL, nHDL, and nHDL/HDL ratio.
Furthermore, cranberry juice consumption improved endothelium-dependent relaxation in the aorta of ovariectomized rats by restoring p-eNOS level (endothelial nitric oxide synthase.
Overexpression of renin-angiotensin system markers (angiotensin-converting enzyme, angiotensin II, and angiotensin II type 1 receptor) associated with blood pressure was also inhibited by commercial cranberry juice.
Furthermore, commercial cranberry juice also normalizes the elevated NAD(P)H oxidase expression and oxidative stress involved in the increased levels of ROS.
Based on the findings, researchers concluded. " the novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles".
Taken together, cranberry may be considered a remedy for the prevention and treatment of cardiovascular disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats by Yung LM1, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Vanhoutte PM, Yao X, Huang Y. (PubMed)
#Phytochemical #Sinigrin Stimulates a Protein and Gene Associated with A Reduced Risk of #LiverCancer, Researchers Say
Kyle J. Norton
Sinigrin may be the next-generation natural and bioactive compound processed an antiproliferative activity against the progression of cancer, according to studies.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
From the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
The programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dr. Albanes D, in the study of cell proliferation as a major risk factor for cancer, said, "Caloric restriction strongly inhibits the development of neoplasia in rodents, and there is evidence of a positive relationship between cancer and body weight in humans".
And, "A recent link between adult stature and cancer incidence similarly implicates a lasting effect for growth and possibly for early nutrition in carcinogenesis. It is postulated that cancer risk is proportional to the number of proliferating cells, which in turn depends on both the number of cells and the rate of cell division within the tissue".
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers on finding a bioactive compound for the treatment of liver cancer, one of the leading causes of cancer death worldwide. investigated the anti-proliferative activity of sinigrin, the major ingredient present in Brassica nigra.
In a model of carcinogen-induced hepatotoxicity in rats, the selected animals were orally administered with sinigrin on a daily basis for three months before sacrifice.
During the experiment, the injection of sinigrin significantly inhibited the proliferation of liver tumor cells, observed by the reduction of the number of surface tumors in the rat liver.
Sinigrin induced apoptosis of liver cancer cells by exhibiting the expression of a protein associated with tumor suppression in the host rats, namely, the p53.
Furthermore, the application of sinigrin-induced cancer apoptosis by stimulating the production of a protein involved in cell death programming and a gene involved in cellular differentiation.
Interestingly, in the additional analysis of the sinigrin anti-liver cancer activity, researchers showed that the bioactive compound not only inhibits cancer cells from proliferation through cell cycle arrest but also restores liver function without inducing liver toxicity.
The results strongly suggested that sinigrin processed significant anti-liver cancer properties via several genes and pathways.
Dr. Jie M, the lead scientist wrote in the final report, "Sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlights the potential of sinigrin as an anti-cancer agent for liver cancer".
Taken altogether, sinigrin found in Brassica nigra may be considered a functional supplement for the prevention and treatment of liver cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(2) Are cell number and cell proliferation risk factors for cancer? by Albanes D1, Winick M. (PubMed)
Sinigrin may be the next-generation natural and bioactive compound processed an antiproliferative activity against the progression of cancer, according to studies.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
From the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
The programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dr. Albanes D, in the study of cell proliferation as a major risk factor for cancer, said, "Caloric restriction strongly inhibits the development of neoplasia in rodents, and there is evidence of a positive relationship between cancer and body weight in humans".
And, "A recent link between adult stature and cancer incidence similarly implicates a lasting effect for growth and possibly for early nutrition in carcinogenesis. It is postulated that cancer risk is proportional to the number of proliferating cells, which in turn depends on both the number of cells and the rate of cell division within the tissue".
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers on finding a bioactive compound for the treatment of liver cancer, one of the leading causes of cancer death worldwide. investigated the anti-proliferative activity of sinigrin, the major ingredient present in Brassica nigra.
In a model of carcinogen-induced hepatotoxicity in rats, the selected animals were orally administered with sinigrin on a daily basis for three months before sacrifice.
During the experiment, the injection of sinigrin significantly inhibited the proliferation of liver tumor cells, observed by the reduction of the number of surface tumors in the rat liver.
Sinigrin induced apoptosis of liver cancer cells by exhibiting the expression of a protein associated with tumor suppression in the host rats, namely, the p53.
Furthermore, the application of sinigrin-induced cancer apoptosis by stimulating the production of a protein involved in cell death programming and a gene involved in cellular differentiation.
Interestingly, in the additional analysis of the sinigrin anti-liver cancer activity, researchers showed that the bioactive compound not only inhibits cancer cells from proliferation through cell cycle arrest but also restores liver function without inducing liver toxicity.
The results strongly suggested that sinigrin processed significant anti-liver cancer properties via several genes and pathways.
Dr. Jie M, the lead scientist wrote in the final report, "Sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlights the potential of sinigrin as an anti-cancer agent for liver cancer".
Taken altogether, sinigrin found in Brassica nigra may be considered a functional supplement for the prevention and treatment of liver cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(2) Are cell number and cell proliferation risk factors for cancer? by Albanes D1, Winick M. (PubMed)
#Phytochemical 3,3'-#Diindolylmethane Inhibits #GastrointestinalCancer by Acting Upon Several Cellular and Molecular Processes
Kyle J. Norton
Scientists may have found a bioactive ingredient for the treatment of gastrointestinal cancer with no side effects, according to studies.
Gastrointestinal (GI) cancer is a group of cancers, affecting the digestive system, including esophagus, gallbladder & biliary tract, liver, pancreas, stomach, small intestine, bowel, and anus
The digestive system consists of the gastrointestinal tract and other parts of the accessory organs of digestion including the tongue, salivary glands, pancreas, liver, and gallbladder), involved in the function of breaking down food into smaller and smaller components then absorbed before passing them as nutrients and fluids to the body.
Most cases of gastrointestinal cancer start in the cells on the surface of the inner lining tissues, depending on the location of the affected organs.
At the early stage, most patients are asymptomatic due to the small size of the tumor. However, at the later stage, after penetrating into deeper layers of the organ, cancer cells can travel through blood and fluids circulation to infect other healthy tissues or organs, leading to secondary metastasis.
At this stage, besides sharing the general symptoms of other types of cancer, gastrointestinal cancer also cause symptoms of severe pain and bleeding due to the overgrowth of tumor size that has suppressed the nearby blood vessels and nerve cells.
The exact causes of gastrointestinal cancer are not identified. However, genetic preposition, unhealthy lifestyle and medical conditions are some of the prevalent risks of the disease.
Some researchers suggested that a poor diet may have a strong implication on the incidence of gastrointestinal cancer.
Dr. Reilly T. Enos, the lead scientist said, "High-fat-diet (HFD) consumption is associated with colon cancer risk".
And, "HFDs with the highest SF content had the greatest concentration of Muc2. Our data suggest that high dietary SF is protective in the AOM/DSS model of colon cancer, which may be due, at least in part, to the ability of SF to maintain intestinal barrier integrity through increased colonic Muc2".
With an aim to find a natural compound for the treatment of gastrointestinal cancers, researchers examined the 3,3'-Diindolylmethane (DIM) activity against effective gastrointestinal cancers.
In vivo and vitro, injection of the DIM acted upon several cellular and molecular processes in gastrointestinal cancer cells.
In cancer cells apoptosis, DIM initiated production reactive oxygen species (ROS) in generating stress, triggering DNA damage by increasing the cytotoxicity.
In angiogenesis, DIM inhibited the protein associated with the generation of a new blood vessel for cell survival and proliferation.
In cell cycle regulation, DIM deactivated the expression of protein kinases which play critical roles in cancer cell division.
Furthermore, DIM triggers cellular endoplasmic reticulum (ER) stress and apoptosis within the cancer cells.
In autophagy, DIM inhibited autophagy that leads to cell death.
In metastasis, DIM inhibited the growth of human cancer cells by interfering with multiple signaling pathways, involved restraining invasion, migration, and promoting apoptosis.
Furthermore, DIM used combined with conventional chemo drugs or therapeutic chemicals increased the efficacy of other drugs for the treatment of gastrointestinal cancer.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of gastrointestinal cancers, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer by Kim SM. (PubMed)
Scientists may have found a bioactive ingredient for the treatment of gastrointestinal cancer with no side effects, according to studies.
Gastrointestinal (GI) cancer is a group of cancers, affecting the digestive system, including esophagus, gallbladder & biliary tract, liver, pancreas, stomach, small intestine, bowel, and anus
The digestive system consists of the gastrointestinal tract and other parts of the accessory organs of digestion including the tongue, salivary glands, pancreas, liver, and gallbladder), involved in the function of breaking down food into smaller and smaller components then absorbed before passing them as nutrients and fluids to the body.
Most cases of gastrointestinal cancer start in the cells on the surface of the inner lining tissues, depending on the location of the affected organs.
At the early stage, most patients are asymptomatic due to the small size of the tumor. However, at the later stage, after penetrating into deeper layers of the organ, cancer cells can travel through blood and fluids circulation to infect other healthy tissues or organs, leading to secondary metastasis.
At this stage, besides sharing the general symptoms of other types of cancer, gastrointestinal cancer also cause symptoms of severe pain and bleeding due to the overgrowth of tumor size that has suppressed the nearby blood vessels and nerve cells.
The exact causes of gastrointestinal cancer are not identified. However, genetic preposition, unhealthy lifestyle and medical conditions are some of the prevalent risks of the disease.
Some researchers suggested that a poor diet may have a strong implication on the incidence of gastrointestinal cancer.
Dr. Reilly T. Enos, the lead scientist said, "High-fat-diet (HFD) consumption is associated with colon cancer risk".
And, "HFDs with the highest SF content had the greatest concentration of Muc2. Our data suggest that high dietary SF is protective in the AOM/DSS model of colon cancer, which may be due, at least in part, to the ability of SF to maintain intestinal barrier integrity through increased colonic Muc2".
With an aim to find a natural compound for the treatment of gastrointestinal cancers, researchers examined the 3,3'-Diindolylmethane (DIM) activity against effective gastrointestinal cancers.
In vivo and vitro, injection of the DIM acted upon several cellular and molecular processes in gastrointestinal cancer cells.
In cancer cells apoptosis, DIM initiated production reactive oxygen species (ROS) in generating stress, triggering DNA damage by increasing the cytotoxicity.
In angiogenesis, DIM inhibited the protein associated with the generation of a new blood vessel for cell survival and proliferation.
In cell cycle regulation, DIM deactivated the expression of protein kinases which play critical roles in cancer cell division.
Furthermore, DIM triggers cellular endoplasmic reticulum (ER) stress and apoptosis within the cancer cells.
In autophagy, DIM inhibited autophagy that leads to cell death.
In metastasis, DIM inhibited the growth of human cancer cells by interfering with multiple signaling pathways, involved restraining invasion, migration, and promoting apoptosis.
Furthermore, DIM used combined with conventional chemo drugs or therapeutic chemicals increased the efficacy of other drugs for the treatment of gastrointestinal cancer.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of gastrointestinal cancers, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer by Kim SM. (PubMed)
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