#Bromelain Inhibits Alzheimer's disease by Preventing A Beta Accumulation in the Brain and #Vasculature, According to Studies

Kyle J. Norton

Alzheimer's disease (AD) is a neurodegenerative disease correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.

According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease. In Canada, approximately, over half a million Canadians live with dementia accompanied by the 25,000 new cases diagnosed every year.

Believe it or not, in 2016, dementia cost Canada over $10 billion, including the healthcare system and out-of-pocket caregiver costs.

Epidemiologically, cigarette smoking, midlife high blood pressure, and obesity, diabetes, cerebrovascular lesions, and psychosocial factors (eg, high education, active social engagement, physical exercise, and mentally stimulating activity) are associated with prevalent risk of AD development.

Some researchers in evaluated that the increased AD in older adults in the Western world over the past few decades may be correlated to the promotion of a high-fat diet.


Dr. Peter Thériault, the lead researcher wrote, "WD promotes systemic inflammation by increasing the levels of blood-circulating monocytes and monocyte chemotactic protein-1 production, which is accompanied by an augmentation of oxidized-low density lipoprotein levels in blood circulation".


And, "At the blood-brain barrier (BBB), WD potentiates the age-induced increase of Aβ 1-40 accumulation and exacerbates the oxidative stress, specifically in cerebral microvasculature. These effects were accompanied by the dysfunction of pericytes, thus altering BBB functionality without compromising its integrity".

In other words, if you are a high-diet follower, you are at high risk of AD developing.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In finding a potential compound for the treatment of Alzheimer's disease, researchers investigated the ability of bromelain, a plant cysteine protease derived from pineapple stems interact with synthetic Aβ42 monomers and oligomers.

According to the tested assays, bromelain protected the neuron successfully by degrading Aβ42 monomers and low and high-molecular-weight oligomers.

Examined the effects of bromelain preparations of 3 and 6 mU added to the cerebrospinal fluid (CSF), the levels of Aβ42 monomers and oligomers were significantly reduced, compared to that of the same standard Aβ42 preparations incubated in CSF without bromelain


Furthermore, the concentration of bromelain incubations with 0.1, 0.5, and 1 mU/ml was not toxic to the central nervous system.

Based on the findings, researchers said, "These results represent an important insight into the action of bromelain on Aβ42 oligomers, suggesting its potential use in the therapy of AD".

In order to know more information about bromelain anti-Alzheimer's disease activity, researchers examined a beta-degrading activity of diverse alpha 2-macroglobulin (alpha 2-M)-proteinase including trypsin, alpha-chymotrypsin, and bromelain (125)I-A beta 1--42.

The complex showed a strong degradation of (125)I-A beta 1--42.

In Ex vivo, oral administration of high doses of proteinases displayed an enhanced degradation of (125)I-A beta 1--42 in the blood of volunteers.

In other words, the complexes exhibited a significant A beta catabolism, thus reducing the risk of developing AD by preventing A beta accumulation in the brain and vasculature.

Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of Alzheimer's disease, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain Degrades Aβ1-42 Monomers and Soluble Aggregates: An In Vitro Study in Cerebrospinal Fluid of Alzheimer's Disease Patients by Sancesario GM1, Nuccetelli M2, Cerri A3, Zegeer J2, Severini C4, Ciotti MT5, Pieri M2, Martorana A3, Caltagirone C1,3, Nistico R5,6, Bernardini S. (PubMed)
(2) Alpha 2-macroglobulin-mediated degradation of amyloid beta 1--42: a mechanism to enhance amyloid-beta catabolism by Lauer D1, Reichenbach A, Birkenmeier G. (PubMed)
(3) High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice by Peter Thériault,1 Ayman ElAli,2 and Serge Rivest. (PMC)

#Betanin Processes #LungCancer Inhibitory Effects Involving #Apoptosis and #Angiogenesis, According to Studies

Kyle J. Norton

The lungs are a pair of spongy, air-filled organs located on either side of the chest with the main function to process gas exchange during breathing.

In other words, the lung transfer life-giving oxygen into the blood supply and remove carbon dioxide produced by cells metabolism from the blood.

Additionally, the lung is also the first-line defense against inhaled particles and prevent the circulation of emboli such as blood clot (thrombus), fat globule (fat embolism), a bubble of air or other gas (gas embolism), or foreign material.

Lung cancer is a medical condition characterized by irregular cell growth in the lung as a result of the alternation of cells in the lung tissue.

Most cases of lung cancer start in the cell on the surface of the inner lining of the lung tissue, before proliferating into deeper layers to induce a tumor.

At the early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the proliferation continues over time, as the later stage, the primary lung cancer not only can elevate the general symptoms shared by all cancers accompanied by localized specific symptoms such as severe pain and bleeding but also travel a distance away from the lung to cause secondary metastasis via circulation of blood and fluids.

The most common secondary metastatic cancers from primary lung cancer are the adrenal gland, bones, brain, and liver.

Out of many risk factors associated with lung cancer, smoking has been found to have a strongly negative implication to induce the early onset of the disease.

Dr. Ozlü T, the lead scientist said, "Nowadays, around one-third of adults are known to be smokers, and smoking rates are increasing among the female population. It is estimated that deaths attributable to tobacco use will rise to 10 million by 2025, and one-third of all adult deaths are expected to be related to cigarette smoking".

And, " The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking. The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers".

The finding strongly suggested the risk of lung cancer in smokers is substantially higher compared to non-smokers.

Betanin is a Phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In the urgency to find a natural compound for the treatment of lung cancer, researchers examined the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models.

The study included Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) induced lung tumors in female A/J mice, followed by the treatment of betanin in drinking water.


Betanin significantly decreased tumor multiplicity and tumor load induced by Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P).

Precisely, tumor multiplicity and tumor load were decreased by 20% and 39% in the VC lung model, and by 46% and 65% in the B(a)P lung model, respectively.

Betanin inhibited the lung tumor by reducing the number of microvessels formation and increasing the expression of a protein associated with programmed cell death.

In other words, the lung tumor inhibitory effects were involved in the induction of apoptosis and angiogenesis.

The findings strongly suggested that betanin significantly inhibits lung tumorigenesis in vivo.

Moreover, compared to capsanthin, cranberry, red onion skin, and short and long red bell peppers, betanin showed a vitro inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction using Raji cells.

According to the results from the lung bioassays, betanin also revealed a significant lung tumor inhibitory effect.

Taken together, betanin may be considered a supplement for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis by Zhang Q1, Pan J, Wang Y, Lubet R, You M. (PubMed)
(2) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H. (PubMed)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)

#Phytochemical #Betanin Inhibits #ProstateCancer Volumes and #AdverseEffects Caused by Chemodrug Doxorubicin, Researchers Suggest

Kyle J. Norton

Prostate cancer is a medical condition associated with cell growth disorderly in the tissue of the prostate.
The prostate is a reproductive gland in men that have the shape and size of a walnut located between the bladder and the penis found in front of the rectum.

The gland has a unique function in the making of prostate fluid, one of the components of semen.

Prostate cancer is one of the slowest-growth of cancer in men. Prostate cancer may take years to develop before affecting the patients with symptoms.

Most cases of prostate cancer are found in older men. However,
The disease also affects men before the age of 40.

Believe it or not, about 1 man in 9 will be diagnosed with prostate cancer during his lifetime. According to the statistics, about 6 cases in 10 are diagnosed in men aged 65 or older.

In the US, approximately 1,700,000 new cases are diagnosed every year. Prostate cancer also causes the death of 609,640 patients.

The 5-year survival rate for diagnosed local or regional prostate cancer is nearly 100%.

Although there are many risk factors involved in the onset of the condition, some researchers suggested that widespread prostate cancer over the past few decades may correlate to the promotion of a high-fat diet in the US.

Dr. Amir Bagheri, the lead scientist in the cancer team wrote, "Prostate cancer is one of the most common types of cancer with a high mortality rate".

And, "After adjustment for potential confounders, a healthy dietary pattern was associated with decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81; trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037)".

The findings strongly suggested that men who follow the Western diet pattern are associated with an increased risk of prostate cancer compared to those who do not.

Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find an effective compound for the treatment of prostate cancer, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the androgen-independent human prostate cancer cells (PC-3).

According to the tested assays, both doxorubicin and the beetroot extract exhibited similarly a dose-dependent cytotoxic effect in the two cancer cell lines.

The cytotoxicity of the beetroot extract was significantly lower when compared to doxorubicin, however, the extract continued to decrease the growth rate of the PC-3 cells by 3.7% in 3 days vs. 12.5% in 7 days at the concentration of 29 µg/ml, compared to those of doxorubicin, at the same concentration level.

In further analysis, researchers found that the anti-prostate cancer effects of beetroot extract were attributed to the presence of betanin, the major betacyanin constituent in the exhibition of cytotoxicity.

Dr. Kapadia GJ, the lead scientist suggested the beetroot extract (B) when used alone or in combination with doxorubicin (D) may process chemopreventive potentials to mitigate the toxic side-effects of the latter.

In order to reveal more information about red beetroot (Beta vulgaris L.) anti-cancer activity researchers examined the beetroot extract (B), approved by Food and Drug Administration and European Union as red food color E162 against cancers.

In pancreatic (PaCa), breast (MCF-7), and prostate (PC-3) tumor cells of human origin, D showed an overall positive reduction in drug concentration when combined with B in its cytotoxicity profile.

The synergistic cytotoxicity was best when the B:D ratio of 1:5 was used in PaCa cells at IC50, IC75, and IC90 dose levels.

The findings strongly supported the potential use of red beetroot extract-doxorubicin combination in treating human prostate cancer.

In other words, red beetroot extracts not only processed the potential to improve the anti-cancer effects of doxorubicin through reduced volume used in prostate cancer treatment but also inhibited the doxorubicin's adverse effects.

Taken altogether, betanin used alone or combined with other medicines may be considered supplements for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

(2) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ1, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. (PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, 1 , 2 Seyed Mostafa Nachvak, 1 ,* Mansour Rezaei, 3 Mozhgan Moravridzade, 1 , 2Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

#PhyticExtract From Sweet Potato Proceses Anti Diabetes Activity by Promoting #Pancreatic Beta-Cell Function, Scientists Find

Kyle J. Norton

Scientists may have found a natural resource for the prevention and treatment of diabetes with no side effects, according to the studies.
Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

Diabetes is either caused by cells in the pancreas that died off due to the immune system mistakenly attacking the sell in the pancreas or receptor sites clogged up as a result of the excess fat and cholesterol in the bloodstream.

Researchers do not know why the immune system attacks its own tissue. Either they can explain people follow a lifelong intake of the Western diet, only some are susceptible to the onset of the disease, while others do not.

There are many risk factors such as age, ethnicity, family history, impaired glucose tolerance, insulin resistance, being overweight or obese, and a sedentary lifestyle. associated with the onset of the condition, epidemiologically. However, many people with some of the risk factors have never developed diabetes.

Some researchers suggested that an unhealthy diet with high amounts of saturated and trans fat, red meat and processed foods, and low amounts of fruits and vegetables as that of the Western diet is the most common risk factor of diabetes in the Western world.

Dr. David Hefner, in the concern of the Western diet in the risk of diabetes, wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes".

And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".

The results strongly suggested the risk of diabetes can be decreased with a change of diet pattern, from the Western diet to a healthy diet with high amounts of fruits and vegetables.

If you experience some of the belove symptoms such as increased thirst that can not be resolved by intake of liquid, frequent urination, extreme hunger, and unexplained weight loss, you may have type 2 diabetes. Please make sure you check with your doctor to rule out the possibility.

Phytic acid (Inositol hexaphosphate is a phytochemical of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

On finding a natural bioactive compound for the treatment of diabetes with no side effects, researchers examined the effect of the phytic acid supplement on streptozotocin-induced diabetic rats.

Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. According to the assay used for the experiment, the phytic acid supplement-treated group showed an increase in average food intake and a decrease in body weight gain compared to the diabetic and normal control groups.

Compared to other groups, the phytic supplement-treated group also exerted a downtrend in intestinal amylase activity. The spike in random blood glucose in the treatment was also lower compared to others.

Furthermore, the treatment group also displays reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels and levels of serum alkaline phosphatase and alanine aminotransferase activation the indication of improvement of insulin sensitivity.

Moreover, levels of pro-inflammatory cytokines were also lower inthe  phytic acid supplement treated group compared to other groups.

Dr.Omoruyi FO, the lead scientist at the end of the study, wPhytic"phytic acid supplementation may be beneficial in the management of diabetes mellitus".

Additionally, researchers randomly assigned six groups of rats fed to test the anti-diabetes of phytic acid, for 3 weeks as follows:
* Groups 1 and 2 were fed formulated diets supplemented with zinc or without zinc respectively.

* Groups 3 and 4 were fed formulated diets supplemented with zinc plus phytic acid extracted from sweet potatIpomoeamea batatas) or commercial phytic acid respectively.

* Groups 5 and 6 were fed formulated diets supplemented with a phytic acid extract from sweet potato or commercial phytic acid respectively.

On the final day of the experiment, researchers found that phytic acid extract consumption from sweet potatoes and commercial phytic acid plus zinc supplements lowered blood glucose levels.

However, phytic acid supplementation showed no significant decrease in the activity of pyruvate kinase involved in the insulin stimulation of this enzyme activity, compared to the group-fed formulated diets.


Groups fed a phytic extract from sweet potato also exerted a significant increase in the activity of glucose-6-phosphate dehydrogenase in the promotion of pancreatic beta-cell function, compared to the other groups.

Taken together, phytochemical phytic acid may be used for the prevention and combined with the primary medicine for the treatment and management of type 2 diabetes.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats by Omoruyi FO1, Budiaman A1, Eng Y1, Olumese FE2, Hoesel JL3, Ejilemele A3, Okorodudu AO (PubMed)
(2) The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism by Dilworth LL, Omoruyi FO, Simon OR, Morrison EY, Asemota HN(PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (NMA)

#Allicin Suppresses the growrh of #PancreaticCancer Cells and Prolongs the Survival Rate in Vivos, Researchers Show

Kyle J. Norton

Scientists may have found a single ingredient isolated from garlic for the prevention and treatment of pancreatic cancer with no side effects, according to studies.
Cancer of the pancreas or pancreatic cancer is a medical condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably.

Most pancreatic cancers start in the ducts (an exocrine component of the pancreas) that carry pancreatic juices. Pancreatic cancers originating in the glandular tissue account for over 75 - 90% of all cases of exocrine cancers.

At the advanced stage, cancerous cells from the pancreas may travel a distance away to exhibit secondary metastasis.

In Canada, the 5-year net survival including all stages of pancreatic cancer is 8%. In other words, 92% of people diagnosed with pancreatic cancer will die after 5 years.

According to the statistic provided by the American Cancer Society, every year, approximately an estimated 55,000 adults (29,000 men and 26,000 women) in the United States are diagnosed with pancreatic cancer. The incidence rates are 25% higher in black people, compared to white people.

Researchers do not know the causes of the disease. However, age, gender, ethnicity, smoking habit, poor diet and a certain medical condition such as diabetes are associated with the prevalent risks of pancreatic cancer.


Some researchers suggested that pancreatic cancer is also found in high numbers in obese patients and patients with a family history of the disease, compared to others.


Dr. Silverman DT in the assessment of risk factors for pancreatic cancer, in a population-based case-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and ten New Jersey counties from August 1986 through April 1989, including 526 incident cases and 2,153 population controls. wrote, "elevated body mass index and caloric intake had increased risk".

And, " A three-fold risk of pancreatic cancer among first-degree relatives of affected individuals was apparent. Increased risk also was associated with a family history of colon, endometrial, ovary, and breast cancer, suggesting a possible link to hereditary non-polyposis colon cancer".


Allicin is phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

In finding the natural compound for the treatment of pancreatic cancer with no side effects, researchers evaluated the efficacy of combined treatment of the recombinant interleukin-2 (rIL-2) and allicin on pancreatic cancer.

The study includes a total of 60 C57/BL6 nude mice pancreatic cancer xenograft models randomized and assigned into four groups of 15 mice per group: control group, allicin treatment group, rIL-2 treatment group, combined treatment with allicin, and rIL-2 group.


Mice in each group were treated with saline, rIL-2, allicin, or a combination of rIL-2 and allicin by weekly i.v injection for four weeks.


Treatment with the allicin and rIL-2 group significantly suppressed the xenograft growth and prolonged survival time, compared to other groups. Truly, the combined therapy group exerted the most amounts of apoptotic cells.

The combined treatment group anti-pancreatic cancer efficacy was attributed to the activation of levels of CD4+T, in stimulating other immune cells, killing cancer cells and natural killer cells.

Furthermore, allicin and rIL-2 also increased the levels of Interferon-gamma (IFN-γ), a cytokine produced by a variety of cells involved in the immune response against cancer cells, compared to other groups.

Dr. the lead researcher wrote in the final paper, "Combined treatment with allicin and rIL-2 resulted in suppression of tumor growth and prolonged survival time possibly through activation of CD4+T, CD8+T and NK cell".

Taken together, allicin isolated from garlic may be considered a bioactive ingredient for the prevention and combined with the primary therapy for the treatment of pancreatic cancer.

However, intake of allicin in the form of a supplement should be taken with extreme care in the prevention of overdose toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI. (PubMed)
(3) Risk factors for pancreatic cancer: a case-control study based on direct interviews by Silverman DT1. (PubMed)

#BlackBean Inhibits the Risk of Colitis by Decreasing the Concentrations of Lipid and Various Circulating #ProinflammatoryCytokines

Kyle J. Norton


Black bean with abundant chemical constituents and fiber may be considered as functional foods for the prevention and treatment of colitis, a renowned institute indicated.

Colitis is a medical condition of inflammation of the inner lining of the colon.

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the joint study led by the University of Guelph, in vivo, cooked whole-bean flours, with differing phenolic compound levels and profiles, showing a completed inhibition of colitis in a mouse model.


In C57BL/6 mice fed a 20 % navy bean or black bean flour-containing diet or an isoenergetic basal diet (BD) for 2 weeks before the induction of experimental colitis via 7 d dextran sodium sulfate (DSS, 2 % (w/v) in the drinking water) exposure, coincidentally, both groups exerted similarly beneficial and adverse effects in induced locally and systemically while aggravating colonic mucosal damage with unknown identity and systemic inflammation.

In the bean treatment group, the efficacy in ameliorated colitis may be a result of the inhibition of pro-inflammatory expressions, such as colonic inflammatory cytokines (IL-6, IL-9, IFN-γ, and IL-17A) and increased anti-inflammatory IL-10.

In mice with colon inflammation triggered by high-fat diet (HD)-induced obesity, injection of black bean expressed significantly decreased the concentrations of lipid and various circulating proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in mice with HD-induced obesity, in attenuated change associated to colon inflammation.

Furthermore, mice treated with black bean also improved antioxidant status in reduced progression
of reactive oxygen species (ROS) in the induction of oxidative stress.

Dr. Yook JS, the lead researchers said, "BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-κB to decrease the production of proinflammatory cytokines".

Taken together, the black bean may be considered as a functional diet in s reduced risk of colitis in high-risk healthy subjects and treatment of patients with colitis with little or no adverse effects.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA1. (PubMed)

#CruciferousVegetables Process A Strong Anti-Inflammatory Effect, According to Studies

Kyle J. Norton

Intake of cruciferous vegetables may be inversely correlated with the circulating proinflammatory levels of women.
In a total of 1,005 middle-aged Chinese women's studies, the consumption of cruciferous vegetables regularly is associated with lower circulating concentrations of proinflammatory cytokines.

Proinflammatory cytokines, also known as Interleukin (IL) and tumor necrosis factor (TNF), are secreted by the immune system to protect our body from inducing fever, inflammation, tissue destruction, etc.

Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Further to the study, Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells exhibited the induction of apoptosis in the cancer cell line, through the involvement of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin.

Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through an induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.

Other phytochemicals found the vegetables, such as 3,3'-diindolylmethane (DIM), a derivative of indole-3-carbinol, also expressed anti-proinflammatory effects through interleukin (IL)-1beta, IL-6, and tumor necrosis factor.

In fact, chemical compounds found in the vegetable, not only inhibited the pro-inflammatory cytokines in the expression of chronic diseases and cancers but are also involved in other aspects, such as environment airborne particulate pollutants, according to the East Campus - Laurentian University.

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Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in ginger-dione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH. (PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)