Liquid Extracts From #Artichoke Improves Liver Functioning by Enhancing Liver Cell Regeneration, According to Studies

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have found a herbal remedy for the improvement of liver function, according to studies.

The liver function plays a critical role in filtering blood that comes from the intestinal before passing them to other organs and tissues. The reddish-brown organ also detoxes toxic chemicals and metabolizes medicine and secrete bile to the intestine for breaking down food and absorbing nutrients.

Additionally, the liver is found to process the ability to secrete proteins such as albumin, fibrinogens, and apolipoproteins into the blood for the regulation of oncotic pressure, blood clotting, and lipoprotein metabolism, respectively.

There are many factors that can disrupt liver function including viral infection, alcohol use, or obesity, leading to scar formation in the liver tissue.

Long-term untreated chronic liver infection that causes the replacement of normal liver tissue by scar tissues eventually leads to cirrhosis, a non-reversible, dangerous condition that can lead to liver failure and cancer.

At the early stage of liver disease, most patients are asymptomatic. However, as the disease progresses patients may experience unspecific symptoms of loss of appetite, fatigue, general malaise, gastrointestinal discomforts, or weight loss.

At the advanced stage severe on the right side of the abdomen, jaundice, pale stool, harden urine color, spiderlike blood vessels on the skin, and redness in the palms of the hands.


Liver damage at this stage may cause loss of period in some women and loss of sex drive, breast enlargement, or testicular atrophy in men.

In severe cases, patients also have symptoms of confusion, drowsiness, and slurred speech.


Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

In finding a natural compound for enhancing liver function, researchers at the Laboratoire de pharmacology examined the liver-protective effects of artichoke (Cynara scolymus) leaf extract.


Injection of artichoke extract improved the liver function in the production of bile and liver lipid production and lipid recycling by lowering blood cholesterol.

In animal models, the liquid extracts of the roots and leaves of artichokes were also found to demonstrate an ability to protect the liver, possibly in enhancing liver cell regeneration.

Furthermore, the administration of artichoke extract reduced the risk of cardiovascular disease by lowering risk factors associated with liver function in regulating cholesterol and triglycerides.

According to the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH), artichoke improved the function of the liver by improving liver enzymes which were significantly reduced in NASH.

Taken altogether, artichoke may have a strong implication in improving liver function in many aspects, pending the validation of larger sample sizes and multicenter studies.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits by Ben Salem M1, Affes H2,3, Ksouda K1, Dhouibi R1, Sahnoun Z1, Hammami S1, Zeghal KM. (PubMed)

#AloeEmodin Inhibits High Blood Pressure by Decreasing Vascular Smooth Muscle Stiffness, Scientists Show

Kyle J. Norton

Good news to people with hypertension, Aloe Vera may be a potential therapeutic agent for lowering high blood pressure a renowned University study suggested.

Hypertension is a condition of abnormally high blood pressure, leading to symptoms of headaches, shortness of breath, or nosebleeds......

Hypertension is a measurement with home systolic/ diastolic BP > or = 135/85 mmHg.

According to statistics, the prevalence of hypertension affects over 39.4% of men and 29.3% of women in the Western World.

Prolong untreated hypertension is found to induce complications of strokes, heart attacks, heart failure, or kidney disease.

Some researchers suggested that patients who are actively in modulated daily high blood pressure may be benefits from reduced risk of stroke by 35%, heart attack by 20%, and heart failure by 50%.

According to the WHO-based Healthy Diet Indicator (HDI), the American Heart Association 2006 Diet and Lifestyle Recommendations(4),
* The prevalence of untreated hypertension and treated hypertension was 22.4% and 8.5%.

* Patients with untreated hypertension had significantly lower HDI and AI-84 scores compared with non-hypertension.

* After adjusting for age, energy intake, smoking habit, alcohol drinking, physical activity and salt intake, a low adherence to HDI and a lowest quartile of AI-84 score were associated with a significantly higher prevalence of untreated hypertension, with an OR of 3.33 (95% CI 1.39 to 7.94, p=0.007) and 2.23 (1.09 to 4.53, p=0.027), respectively.

These results are agreed to a general and popular belief that an unhealthy diet plays an important role in the induction of high blood pressure. Furthermore, the lower dietary quality was associated with an increased prevalence of untreated hypertension.

People who eat more fruits and vegetables compared to average daily intake are associated with a significantly lower risk of hypertension.

Dr. Utsugi MT in the comparison of fruits and vegetable intake daily said, "the highest-tertile consumptions of fruits, vegetables, potassium, and vitamin C were associated with a significantly lower risk of hypertension (45%, 38%, 46%, and 43% lower risk of home hypertension, respectively(5)".

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its enormous health benefits. Aloe vera has also been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol,

According to the Hamdard University, aloeemodin, aloin A, a chemical compound found in Aloe Vera showed to express hypotensive effects by lower mean arterial blood pressure by 26 %, 52 %, and 79 % in the corresponding doses of 0.5, 1, and 3 mg/kg in an animal study.


Dr. Saleem R, the lead author of the study suggested that Aloeemodin has emerged as a potent hypotensive agent in the current pharmacological investigation.

In a total of In a double-blind, placebo-controlled, crossover study, healthy, Aloe-emodin, another major chemical compound\ inhibited vascular smooth muscle stiffness, a condition in the development of hypertension, involved cells in supporting structural and biochemical and the interior surface of blood vessels.

In hypertension, increased large-artery stiffness is partly due to the intrinsic mechanical properties of vascular smooth muscle cells.

More importantly, for smooth muscle cells derived from hypertensive and control rats studies, treatment of Aloe-emodin also significantly reduced hypertension by improving the elastic value of vascular smooth muscle cells, through its effects on vascular smooth muscle cell cytoskeletal proteins in the regulated function of cell division.

Other researchers suggested that the antihypertensive properties of Aloe-emodin may be a result of the inhibition of tonic tension and regulated apoptosis, pro- and anti-apoptotic activities on vascular smooth muscle cells.

With all the information collected, Aloe Vera may have an antihypertensive effect in regulated protein in cell production on vascular smooth muscle which is the main cause of high blood pressure, but more precise understanding may be necessary to reassess this pharmaceutical value.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.



Sources
(1) Hypotensive effect of chemical constituents from Aloe barbadensis by Saleem R1, Faizi S, Siddiqui BS, Ahmed M, Hussain SA, Qazi A, Dar A, Ahmad SI, Qazi MH, Akhtar S, Hasnain SN. (PubMed)
(2) Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension by Sehgel NL1, Zhu Y, Sun Z, Trzeciakowski JP, Hong Z, Hunter WC, Vatner DE, Meininger GA, Vatner SF. (PubMed)
(3) Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta by Lim KM1, Kwon JH, Kim K, Noh JY, Kang S, Park JM, Lee MY, Bae ON, Chung JH.(PubMed)
(4) Diet quality and adherence to a healthy diet in Japanese male workers with untreated hypertension by Kanauchi M1, Kanauchi K(PubMed)
(5) Fruit and vegetable consumption and the risk of hypertension determined by self measurement of blood pressure at home: the Ohasama study by Utsugi MT1, Ohkubo T, Kikuya M, Kurimoto A, Sato RI, Suzuki K, Metoki H, Hara A, Tsubono Y, Imai(PubMed)

Andrographis Ethanolic and Petroleum Ether#Extract Accelerate Wound Healing with Lesser Scarring, Researchers Say

Kyle J. Norton

Andrographis paniculata is also known as Andrographis, is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.. .....
Wound healing is a natural response to restore injured tissues.

Andrographis paniculata leaf showed to process a significant wound healing effect in restoring injured tissues, a mentioned institute suggested.

According to the Universiti Teknologi MARA, the topical application of Andrographis paniculata exerted a strong effect on the rate of wound enclosure with markedly less scar width and contained large amounts of fibroblast proliferation.

In a study of the wound created in four groups of rats in the posterior neck region. A blank placebo applied topically to the wounds of Group 1 and Groups 2 and 3 dressed with a placebo containing 5% and 10% extracts of A. paniculata, groups treated with topical showed a rate of wound healing significantly accelerated in the wound dressed compared to the placebo group.


The wound healing is also increased collagen and less formation of new blood vessels with the absence of inflammatory cells.

Another study, in the evaluation of the effects of andrographis wound healing activity of Swiss Wistar strain rats with either sex with topical application, 2%w/w ointment of ethanol extract and petroleum ether extract prepared in 2% w/w PEG-4000 in comparison to the left untreated control group, treatment groups showed a faster rate of complete healing in day 12 after topical application with wound contractions in petroleum ether extract, the ethanolic extract was at 10.17 and 16.33, respectively.

Dr. Arnabaditya Mohanty, the lead author in the joint study said, "Andrographis paniculate ethanolic extract possesses better wound healing property in comparison to control and also with petroleum ether extract".

Taken together, topical application of Andrographis paniculata leaf and extract may be used as a wound-healing agent in accelerated restored injured tissues with lesser scarring without induced adverse effects.

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Sources
(1) Effect of Andrographis paniculata leaf extract on wound healing in rats by Al-Bayaty FH1, Abdulla MA, Abu Hassan MI, Ali HM.(PubMed) and(University of Malaya)
(2) Preliminary Pytochemical Screening and Wound Healing Activity of Andrographis Peniculata by Arnabaditya Mohanty1 , Dusmanta Kumar Pradhan1 , Manas Ranjan Mishra1 , Jitendra Kumar Sahoo1 , Ashutosh Mishra *2, Bankim Chan(Journal of Chemical and Pharmaceutical Research)

#Formula OptiBerry IH141 Including all Berries and Blueberry #Extract Process Superior Anti-Angiogenic Properties, Studies Find

Kyle J. Norton

According to studies, Bilberry may process a unique function in blocking the formation of new blood vessels to fuel tumor growth.

Angiogenesis is the development of new blood vessels from the existing vasculature. The process has occurred throughout life in humans in the form of health and disease.

Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients,

In a tumor, the availability of nutrients is limited, therefore, for the tumor to survive and grow continuously, the tumor cells induce the formation of a new blood supply from the preexisting vasculature by stimulating the protein associated with the pro-angiogenesis and facilitation of angiogenesis, such as vascular endothelial growth factor.

In other words, if we can cut off the blood vessels that provide nutrients to the tumor, we may cure cancers.

Dr. Adair TH, the lead scientists in the investigation of the angiogenesis in diseases and cancer said, "Stimulation of angiogenesis can be therapeutic in ischemic heart disease, peripheral arterial disease, and wound healing. Decreasing or inhibiting angiogenesis can be therapeutic in cancer, ophthalmic conditions, rheumatoid arthritis, and other diseases".

And, "Capillaries grow and regress in healthy tissues according to functional dem bands. Exercise stimulates angiogenesis in skeletal muscle and heart. A lack of exercise leads to capillary regression. Capillaries grow in adipose tissue during weight gain and regress during weight loss.

The results strongly suggested that by allowing or blocking the growth of new blood vessels, angiogenesis may be used as a primary target for the treatment of chronic diseases and cancers

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Researchers on finding a natural compound that blocks the progression of cancer examined the anti-angiogenic activity of berry anthocyanins.

Six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry) included in the study were analyzed for the anti-angiogenic (the ability to reduce unwanted growth of blood vessels, which can lead to varicose veins and tumor formation) properties.

Formula OptiBerry IH141, including all berries used in the study, demonstrated superior anti-angiogenic properties compared to the other combinations tested.


OptiBerry significantly inhibited free radical and proinflammatory cytokines in the expression of VEGF (Vascular Endothelial Growth Factor) associated with the formation of the new blood vessels.

According to the Matrigel assay using human microvascular endothelial cells, OptiBerry reduced the new blood vessel formation by impairing angiogenesis.

Furthermore, endothelioma cells pretreated with OptiBerry showed a diminished ability to form hemangioma and markedly decreased tumor growth by more than 50% through its anti-angiogenic, and anti-carcinogenic properties.

In order to reveal more information about berry's anti-angiogenic activity to prevent and treat cancer, researchers investigated the six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seed, and strawberry) and a grape seed proanthocyanidin extract (GSPE) against the formation of new blood vessels for cancer proliferation.


Wild bilberry and blueberry extracts possessed the highest antioxidant activity observed by the ORAC values compared to other berries.

In other words, wild bilberry and blueberry extracts inhibited the overexpression of free radicals and proinflammatory cytokines in stimulating the production of VEGF (Vascular Endothelial Growth Factor) in enhancing angiogenesis.


Interestingly, these activities of wild bilberry and blueberry extracts were not shared by other antioxidants such as alpha-tocopherol or GSPE but were commonly shared by pure flavonoids.

Taken together, bilberry used alone or combined with other berries may be considered functional remedies for the prevention of angiogenesis and treatment of cancer cell proliferation by stimulating the formation of a new blood vessel, pending the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula by Bagchi D1, Sen CK, Bagchi M, Atalay M. (PubMed)
(2) Anti-angiogenic property of edible berries by Roy S1, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. (PubMed)
(3) Chapter 1Overview of Angiogenesis by Adair TH, Montani JP.. (NCBI)

#Herbal #Artichoke's Ethanolic #Extract Show An Inhibited Effect on Liver Oxidative Stress Markers Associated with the Onset of #LiverDiseases, According to Studies

Kyle J. Norton

The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins.

The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.

Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.

Symptoms of liver diseases include jaundice, abdominal pain, swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.

If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver disease.

Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions, wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".

And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".


The results clearly and strongly suggested that reducing the intake of alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including ALD.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Scientists on finding a natural ingredient that processes liver protective effects evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.

Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.

Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, and the liver oxidative stress markers but also reduced the levels of triglyceride, and total cholesterol.

Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.

According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.

The results indicated a liver protective activity in artichoke was attributed to the inhibition of the pro-inflammatory proteins in acute alcohol-induced liver injury mice.

In order to reveal more information about the liver protective effect of artichokes, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis, and its complications are the major cause of death in infected cases.

Mice selected for the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ), and PZQ respectively. The 4th was a positive control and the 5th was the negative control group. and were compared to PZQ.

Injection of ALE and ALE + praziquantel (PZQ) caused a significant reduction of granuloma diameter, improvement of liver functions, and liver fibrosis.

Furthermore, ALE induced statistically significant changes in hepatic stellate cells (HSCs) distribution.

Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.


Unfortunately, although, the herbal extract exerted a strong liver protective activity, it failed to treat S. mansoni infection.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver disease, pending the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects the liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cell recruitment by Sharaf El-Deen SA1, Barakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--the untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)

#Herbal #Artichoke Promotes Bowel Health through Its Probiotic Property, Researchers Suggest

Kyle J. Norton

Bowel problems may be a condition associated with some underlying diseases or syndrome including bowel incontinence, IBS, Colitis, Crohn's, constipation, or other bowel conditions.
Bowel problems can be cured if the causes of the problem are found.

The most common syndrome that does not associate with the underlying disease is constipation, a condition that affects bowel movements.

According to the statistics in the US, constipation affects approximately 2% of the population and the condition is more common in women than men.

Patients with constipation may experience symptoms of abdominal pain, bloating, and the feeling of not completely passing the bowel movement.

Chronic constipation is one of the common causes of hemorrhoids, anal fissures or fecal impaction.

Conventionally, constipation in most cases is treated by the use of a laxative. However long-term use of laxatives may induce diarrhea, intestinal obstruction, and particularly unbalanced levels of salts and minerals in your body.

Therefore, if you currently use one of the over-counter laxatives for the treatment of constipation, please make you know all the side effects for preventive measures.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

In finding a natural compound with bowel health promotion activity, researchers compared the effects of probiotic-enriched artichokes on the treatment of the symptom profile and short-chain fatty acid (SCFA) production in constipated subjects with ordinary artichokes.

20 chronically constipated participants including 3 males and 17 female have selected to a double-blind method and a computer-generated randomization list.


Each patient consumed 180 g per day of ordinary artichokes or artichokes enriched with Lactobacillus paracasei IMPC 2.1 for 15 days.

According to the returned questionnaires, 80% of patients preferred probiotic-enriched artichokes compared to ordinary ones.

The satisfactory relief of symptoms was significantly higher in the probiotic-enriched artichoke compared to ordinary ones.

According to the Bristol stool scale the measurement of fecal retention was lower in the probiotic-enriched artichokes compared to higher in the artichoke group seconded to the control.

GSRS (Gastrointestinal Symptom Rating Scale) of constipation was significantly lower in the probiotic group compared with the baseline.


Furthermore, the short-chain fatty acid (SCFA) production and propionic acid were significantly higher in the probiotic group compared with the baseline.


In order to reveal more information on artichokes in the promotion of bowel health, researchers investigated the chemical compounds inulin and oligofructose, a class of fructans found in the Jerusalem artichoke.

Injection of inulin and oligofructose was found to stimulate the immune system of the body, decrease the pathogenic bacteria in the intestine, and relieve constipation.

Furthermore, inulin and oligofructose also displayed significant effects in the promotion of bowel health by protecting the colon against colon cancer.

Taken together, artichoke, particularly Jerusalem artichoke alone or combined with probiotics may be considered functional remedies for the improvement of bowel health, pending the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Randomised clinical trial: efficacy of Lactobacillus paracasei-enriched artichokes in the treatment of patients with functional constipation--a double-blind, controlled, crossover study by Riezzo G1, Orlando A, D'Attoma B, Guerra V, Valerio F, Lavermicocca P, De Candia S, Russo F. (PubMed)
(2) Applications of inulin and oligofructose in health and nutrition by Kaur N1, Gupta AK. (PubMed)

#Bromelain Shows A Clinically Relevant Improvement in the WOMAC Disability Subscale in Osteoarthritis (OA) Similar to Those of Diclofenac with No Side Effects

By Kyle J. Norton

Osteoarthritis (OA), a form of arthritis, is a condition associated with aging-induced wear and tear on a joint or joint.
The condition is very common in older adults, affecting over 25 million people in the US with no sign of stopping.

According to the University of Porto Medical School, the differences in prevalence and incidence estimates of osteoarthritis (OA), according to the case definition, are in the knee, hip, and hand joints(3).

The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty in moving the joint or joints(7). The pain usually gets worse in a change of weather, at night.
In advanced diseases, pain can occur even at rest(8).

Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).

Some researchers suggested that OA is not simply a disease related to aging or mechanical stress of joints but rather a “metabolic disorder(70)(71)” interrelated to lipid, metabolic, and humoral mediators(70).

Indeed, OA has been linked not only to obesity(46)(47) but also to other cardiovascular risk factors(72)(73), namely, diabetes(74), dyslipidemia, hypertension, and insulin resistance(75).

More precisely, the majority of patients with OA also suffer from one or more of the below conditions
* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).

* Cardiovascular disease
According to Erasmus University Medical Centre, there is an association of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).

*Peripheral vascular disease
According to Himchan Hospital, patients with osteoarthritis are associated with a risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).

* Congestive heart failure
Hypertension, diabetes, and older age have been shown to increase the risk of Congestive heart failure modestly(81).

* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83).

6. Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).

* Respiratory disease
People with respiratory disease are also at a higher risk to develop osteoarthritis (OA), including chronic cough and bilateral infiltrates on chest roentgenogram(86).

* High serum of cholesterol
There is an association between high serum cholesterol levels and both knee and generalized OA, according to the study of 113 females and 133 males with average ages 46 14.2 and 51.54 16.0 years by King Khalid University Hospital(87).

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In finding a natural compound from healthy food for the treatment of inflammatory diseases, researchers examined the effects of bromelain on patients with osteoarthritis of the knee.

The randomized, double-blind placebo-controlled trial included 47 patients with a confirmed diagnosis of moderate to severe knee OA randomized to 12 weeks of bromelain 800 mg/day or placebo, with a 4-week follow-up.

According to the results from 31 patients who completed the trial, including 14 in the bromelain group and 17 in the placebo group, both treatment groups showed clinically relevant improvement in the WOMAC disability subscale only with a mild adverse outcome.

In order to reveal and confirm the effects of bromelain on OA, a joint randomized, single-blind, active-controlled pilot study. led by Mahidol University was conducted in patients with OA for 16 weeks.
40 knee OA patients enrolled in the study were randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).

According to the tested assays,
* At week 4, the improvement of total WOMAC and pain subscales from baseline was observed in both groups, however, two patients in the diclofenac treatment group showed adverse effects that lead to discontinuation of diclofenac.

* At week 16, the bromelain treatment group showed a significant improvement in all aspects, including total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4), compared to baseline values.

* Also compared to the based line, the bromelain-treated group also showed a decrease of plasma MDA and LPS-stimulated PGE2 production,

* Bromelain exerted a similar effect to those of diclofenac after 4 weeks.

Taken altogether, bromelain used alone may be considered supplements for the prevention and treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study by Brien S1, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. (PubMed)
(2) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: Diseases associated with Osteoarthritis by Kyle J. Norton