#Phytochemical 3,3'-Diindolylmethane Promotes Antioxidant Activity Against the Initiation of Chronic Diseases, According to Studies

Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of diseases associated with oxidative stress with no side effects, according to studies.

Oxidative stress is a condition caused either by overexpression of free radicals or depletion of antioxidant enzymes produced by the host.

In other words, the condition of oxidative stress occurs only under the imbalance of the ratio of free radicals and antioxidants.

Antioxidants can be either produced by the body or injected into the body from outside sources such as the consumption of antioxidant-rich fruits and vegetables.

Free radicals are everywhere, including the air we breathe, the food we eat and the body daily functioning such as cell metabolism.

In other words, any chemical compound which has an oxygen molecule can become a free radical after entering our body.

Most healthy individuals can produce enough amounts of antioxidants endogenously to counter the bombards of free radicals. However, people with a weakened immune system such as the elderly, and immature immune systems such as the baby may need the injection of antioxidants from outside sources.

More precisely, people with a weakened immune system do not produce enough antioxidant enzymes to inhibit the chain reaction of free radicals which occurs daily in the body due to the unstable nature of the molecules.
Believe it or not, our body needs to limit levels of some free radicals to function better, including lower blood pressure, and relax blood vessels to move blood, such as nitric oxide NO.


3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

With an aim to find the natural ingredient for the treatment of diseases associated with oxidative stress, researchers investigated the effect of indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) in type 2 diabetes mellitus (T2DM).
The study included selected genetically modified mice (C57BL/6J mice) similar to that of metabolic abnormalities of the human disease after the administration of a high-fat diet (HFD).

Including indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) into the diet showed positively modulated glucose, insulin, and Hb and HbA1c levels in HFD mice against the risk of diabetes complications.

Compared to the HFD group, injection of I3C and DIM protected the infected rat against the formation of lipid peroxidation observed by levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), conjugated dienes (CD).

Furthermore, levels of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were also increased, an indication of the balance of the ratio of antioxidants and free radicals.

Interestingly, I3C and DIM also improved the free radical scavengers such as vitamin C, and vitamin E, and improved the reduced glutathione (GSH) levels in treated mice.

Based on the findings, researchers summarized, "From the study, it was clear that the antioxidant-scavenging action was accelerated in mice treated with DIM than the I3C treatment group which was comparable with the standard drug metformin".

Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3'-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy by Fuentes F1, Paredes-Gonzalez X1, Kong AN. (PubMed)
(2) Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane in C57BL/6J mice by Jayakumar P1, Pugalendi KV, Sankaran M. (PubMed)

#BetaSitosterol inhibits Oxidative Stress induced-#NeurodegenerativeDiseases by Promoting Antioxidant Activity, According to Studies

Kyle J. Norton

The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.

Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.


Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to its nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress present in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

In finding a potential phytochemical for the prevention and treatment of diseases associated with oxidative stress, researchers examined beta-sitosterol (BS), a plant sterol antioxidant activity.

In vitro, HT22 cells and primarily cultured hippocampal cells induced oxidative stress by glucose oxidase (GOX) incorporate BS into the plasma membrane, preventing GOX-induced oxidative stress and lipid peroxidation.

Furthermore, the incorporation of BS into the cell membrane increased the PI3K activity in the promotion of cellular function and recruitment of PI3K to lipid rafts.

Additionally, the levels of p-GSK3beta also in the promotion of cell integrity were also enhanced by the application of BS against the onset of oxidative stress.

Based on the evidence, researchers said, " ...the results provide a better understanding of the beneficial effects of these BS-enriched nutrients on neurodegenerative diseases such as AD".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of diseases associated with oxidative stress, including AD, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3beta signaling by Shi C1, Wu F, Zhu XC, Xu J. (PubMed)

TUBES Gastro Bromelain Tablets Inhibit Symptoms in Patients with Dysmotility-Like Dyspepsia, Researchers Say

Kyle J. Norton

Functional dyspepsia, also known as indigestion, is a symptom in the stomach associated with difficulty in digesting food.

The most common symptoms of indigestion are pain or discomfort in your upper abdomen (dyspepsia) or burning pain behind the breastbone (heartburn) soon after eating.

Some patients may also experience symptoms of feeling full or bloated with no signs of relief.

In serious cases, patients may also experience symptoms of vomiting blood, dark, tarry stools due to damage to the lining of the stomach, shortness of breath, and unexplained weight loss.

If you have some of the aforementioned symptoms, please check with the doctor immediately


Their exact causes of indigestion are multiple. Epidemiologically, female gender, aging, long-term use of pain relievers, such as aspirin and ibuprofen, smoking, and people with long-term psychological problems such as anxiety or depression are some most common factors found in patients with functional dyspepsia.

Conventionally, treatment of functional dyspepsia is totally depending on the condition, including antibiotics for H. pylori infection and medication to reduce pain.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In finding potential and natural compounds for the treatment of functional dyspepsia, researchers examined a dietary integrator composed of sodium alginate, sodium bicarbonate, bromelin, and essential oils in patients affected by functional dyspepsia.

The study included a study of a total of 100 patients with functional dyspepsia diagnosed primarily on the basis of typical symptoms and the exclusion of non-functional gastrointestinal diseases.

According to the symptom classification, All patients were assigned to either dysmotility-like dyspepsia (N.=60) or reflux-like dyspepsia (N.=40).

All patients were treated with TUBES Gastro (0.80 g oral tablets bid after main meals) for 4 weeks, on top of their current treatment with proton pump inhibitors or not.

According to the results from the experiment, TUBES Gastro showed a high statistically significant reduction of the Numerical Rating Scale (NRS) scores at 14 and 28 days: -1.5 (-26.3%) and -3.4 (-59.6%), respectively compared to the baseline in patients with dysmotility-like dyspepsia.

In patients with reflux-like dyspepsia, TUBES Gastro demonstrated a statistically significant reduction of the NRS score at 14 and 28 days: -2.8 (-41.2%) and -4.8 (70.6%), respectively (P<0.0001).

Furthermore, there were no side effects found during the study duration.


Based on the findings, researchers wrote, "TUBES Gastro treatment was effective and well-tolerated in reducing the symptomatology of patients affected by functional dysmotility-like and reflux-like dyspepsia".

In order to reveal additional information about TUBES Gastro anti-functional dyspepsia, researchers at the Molinette Hospital conducted a study to examine the preparation efficacy on a total of 53 consecutive patients (22 males, 31 females; mean age, 54+/-2.5 years) with functional dyspepsia and negative for Helicobacter pylori infection.

Patients classified into four subgroups according to predominant symptom: ulcer-like dyspepsia, Motility-like dyspepsia, reflux-like dyspepsia, and nonspecific dyspepsia, were received TUBES gastro (0.80 g oral tablets bid) for a minimum of 3 months (range, 3-11).

According to the results of patients who completed the study, the preparation showed a strong effect on the improvement in Visual Analogue Scale (VAS). score.

Compared to the based line, the difference in scores between the initial and the final visit was -1.9+/-2.1 cm (range, -6 to +3), or 23.8+/-40.8% (range, -150% to 100%).

Dr. Pellicano R, the lead scientist wrote, "The study results indicate that in the short term TUBES gastro can significantly improve dyspeptic symptoms in dyspeptic patients negative for H. pylori infection".

Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of functional dyspepsia, pending the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Can dietary integrators provide a clinical benefit in the treatment of functional dyspepsia? results from a prospective study with TUBES Gastro by Molteni M. (PubMed)
(2) Benefit of dietary integrators for treating functional dyspepsia: a prospective pilot study.[Article in English, Italian] by Pellicano R1, Strona S, Simondi D, Reggiani S, Pallavicino F, Sguazzini C, Bonagura AG, Rizzetto M, Astegiano M. (PubMed)

#Beta-Sitosterol Exerts a Significant Eddect on #SkinCancer, According to Researchers

Kyle J. Norton

Skin, a large organ that forms the out layers of our body has a serval layer of ectodermal tissue to protect the underlying muscles, bones, ligaments, and internal organs against foreign pathogenic invasion.

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and is often detected at an early stage.

Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.

There are 3 main types of cells in the top layer of the skin (called the epidermis):
Squamous cells, Basal cells, and Melanocytes.

Long-term cumulative sun exposure is one of the major causes of basal cell and squamous cell skin cancer. Exposure to ultraviolet (UV) radiation is the leading cause of melanoma.

Certain risk factors that make some people more susceptible to the development of skin cancer than others include the increase in age, weakened immune system, gender, skin tone, genetic preposition, and family history.


According to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.

Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risks of sun and tanning exposure.

The most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size, or feel or that bleeds, a small lesion with an irregular border, and portions that appear red, pink, white, blue or blue-black.


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

In finding a potential phytochemical for the prevention and treatment of cancer, researchers compared the effects of Betulinic acid (1), betulinic acid-3-acetate (2), 3-acetyl betulin aldehyde (3), oleanolic acid-3-acetate (4), 3-β-hydroxy-28,19-β-olenolide (5), and β-sitosterol (6) were isolated from Platanus orientalis on skin cancer cells.

According to the chemical analysis, (1 ) is the most abundant component (4.63%) compared to the least (5) (0.017%) the least.

All isolated compounds showed a significant cytotoxic effect against human keratinocyte, mouse melanoma, and human skin epithelial carcinoma cancer cells according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

In other words, all compounds found in Platanus orientalis work synergistically against the skin cancer risk in vivo.

Taken together, beta-sitosterol may be considered a supplement for the prevention of od skin cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A validated high-performance thin-layer chromatography method for the identification and simultaneous quantification of six markers from Platanus orientalis and their cytotoxic profiles against skin cancer cell lines by Khan I1, Sangwan PL, Dar AA, Rafiq RA, Farrukh MR, Dhar JK, Tasduq SA, Koul S. (PubMed)

#Herbal #Ashwagandha Reduces the Risk of #Lipid-eroxidation by Inhibiting Parameters Associated with Liver Stress, According to Studies

Kyle J. Norton

Cholesterol, a waxy substance produced by the liver or the dietary plays a critical role to aid digestive function in absorbing nutrients and fluids, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts of cholesterol in the blood have been found to induce plaque built-up on the arterial wall, leading to hypercholesterolemia, a leading cause of heart disease, and stroke.

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

The condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).

People with hypercholesterolemia at the early stage are asymptomatic. However, patients with familial hypercholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor for heart disease, a leading cause of death in the US.

In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people with hypercholesterolemia are getting treatment.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the treatment of high blood cholesterol, researchers examined the ashwagandha root extract's anti hypercholesteremic effects in an animal model.

Selected hypercholesteremic male albino rats were given root powder of WS added to the diet at 0.75 and 1.5 gm/rat/day.

During the experiment, researchers found that the root powder of WS showed a strong anti-hypercholesteremic activity by significantly decreasing levels of total lipids, cholesterol, and triglycerides, in blood plasma.

Furthermore, WS also reduced the levels of cholesterol by significantly increasing plasma HDL-cholesterol levels, HMG-CoA reductase activity, and bile acid content of the liver.

Moreover, lipid-peroxidation associated with liver stress was inhibited by WS administration in hypercholesteremic animals, compared to other normal counterparts.

Based on the findings, researchers said, "It appeared that WS root powder is also effective in normal subjects for decreasing lipid profiles".

Taken together, Ashwagandha may be considered a functional herb for the treatment of hypercholesterolemia, pending the result of a larger sample size and multicenter study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypocholesterolemic and antioxidant effects of Withania somnifera (Dunal) in hypercholesteremic rats by Visavadiya NP1, Narasimhacharya AV. (PubMed)

#CruciferousVegetables' #Sulforaphane Inhibit Oxidativestress Associated with a Risk of Diabetic Vascular Complications, Researchers Say

Kyle J. Norton

Diabetic vascular complications are caused by a diverse group of highly oxidant compounds(advanced glycation end(AGEs) produced by a modern heat-processed diet, inducing pathogenic significance in diabetes and several other chronic diseases.

Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose. It is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Its complications may include renal failure and cardiovascular events.

Intake of Cruciferous Vegetables regularly may be beneficial in reducing the risk of diabetic vascular complications.

Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Dr, Yamagishi S, the lead author said, " the Inhibition of AGE formation, blockade of the AGE-RAGE interaction, and suppression of RAGE expression or its downstream pathways may be novel therapeutic strategies for the treatment of vascular complications in diabetes"

Some researchers insisted that diabetic vascular complications may be blocked if food-advanced glycation end-products aggravate diabetic vascular complications via modulating the RAGE receptors in the removal of AGE.

According to the Kurume University School of Medicine, sulforaphane, a phytochemical compound found in cruciferous vegetables showed a potential effect against diabetic vascular complications, through its interference with pro-inflammatory reactions, and reduction of oxidate stress.

In cultured cells and experimental animals, sulforaphane suppressed inflammatory activation of vascular cells, and induced potential beneficial effects to prevent vascular inflammation and atherosclerosis complication of diabetics.

Therefore, intake of Cruciferous Vegetables may reduce the risk of diabetic vascular complications as sulforaphane, a phytochemical compound in cruciferous vegetables not only inhibited the levels of advanced glycation end but also enhanced the production of Nrf2 in controlling over 500 genes expression of cellular defense mechanisms.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(1) Protective role of sulforaphane against vascular complications in diabetes by Yamagishi S1, Matsui T1. (PubMed)
(2) Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications by Yamagishi S1, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.(PubMed)
(3) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease by Paul C. Evans(PMC)
(4) Food-advanced glycation end products aggravate diabetic vascular complications via modulating the AGEs/RAGE pathway by Lv X1, Lv GH1, Dai GY1, Sun HM2, and Xu HQ3. (PubMed)

#Herbal #Coltsfoot Protects the Small Intestinal Epithelium Against Adverse Effect on #Chemotherapy, Researchers Suggest

Kyle J. Norton

The digestive system including the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body's normal function by providing nutrients and fluids to the body and removing waste through the secretary system.
Digestion is a process of the digestive system by breaking out food after food intake through mechanical and enzymatic action.

The intestinal epithelium formed part of the intestinal mucosal barrier, is the single-cell layer formed the lining of both the small and large intestine(colon) of the gastrointestinal tract with functions to absorb useful substances into the body and block the entry of harmful pathogens.

Dr. Catalioto RM, the lead scientist in examing the intestinal epithelial barrier dysfunction wrote, "Epithelial cells are linked together at the apical junctional complex by tight junctions that reduce the extracellular space and the passage of charge entities while forming a physical barrier to lipophilic molecules".

And, "Cultured intestinal epithelial cells have been extensively used to study intestinal absorption of newly synthesized drugs and the regulation of tight junctions structure and function. In vitro mild irritants, proinflammatory cytokines, toxins and pathogens, and adverse environmental conditions open tight junctions and increase paracellular permeability, an effect often accompanied by immune activation of the enterocytes".

In other words, intestinal epithelium dysfunction induces the risk of various intestinal and non-intestinal disorders including inflammatory bowel disease, celiac disease, and diarrhoeal infection.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

In finding a potential compound for the improvement of digestive functioning, researchers examined the protective effect of Tussilagone (TSL) on mall intestinal epithelium against foreign pathogens.

According to the DNA comet assay, in C57Bl/6 mice, the chemical constituent of polysaccharides from Tussilago farfara L. reduced the intensity of polychemotherapy-induced apoptosis in the intestinal epithelial cells.

In other words, TSL not only enhanced the efficacy of the chemo drug but also inhibited the cytotoxicity of the adverse effect of chemo-induced death or DNA damage of intestinal epithelial cells through its geno-protective properties.

Taken altogether, coltsfoot may be considered a remedy for the protection of small intestinal functioning against damage, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay by Safonova EA1, Lopatina KA2, Vychuzhanina AV2, Mashanova VA2, Razina TG2, Borovskaya TG2, Zueva EP2, Gur'ev AM3, Belousov MV. (PubMed)