Kyle J. Norton
Artichoke may process a substantial and profound effect in managing the levels of postprandial glycemia in diabetics, according to studies.
Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.
Postprandial blood glucose is the level taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.
Management of postprandial blood glucose has become an essential feature for diabetics against the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose as a result of the cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Insulin resistance is a hallmark of diabetes. The exact causes of insulin resistance are unknown. Researchers do not know why people with the same health conditions in the same family, are susceptible to the onset of diabetes while others do not.
However, some researchers suggested that an unhealthy diet with high saturated and trans fat, red meat, and processed foods is one of the major risk factors associated with the onset of the disease in the Western world compared to a traditional diet.
In other words, if you follow the Western diet, you are at an increased risk of diabetes development.
Dr. David Hefner in concerned about the risk of diabetes in patients who are fans of the Western diet wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes" and "That's what researchers at the Harvard School of Public Health have found and reported in the Annals of Internal Medicine."
The doctor continued, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
The finding argued the risk of diabetes is reduced if you change your Western diet pattern to a traditional diet with high fruits and vegetables and whole-grain with a limited intake of saturated and trans fat, processed foods, and red meat.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
With an aim to find a natural ingredient doe the treatment of hyperglycemia with no side effects, researchers examined the traditional use of artichoke (Cynara scolymus L., Asteraceae family) preparations for lowering post-prandial glycemia.
The study included non-selected Wistar and genetically obese Zucker rats treated acutely with a purified extract of Cynara scolymus flowering heads (500-1500 mg/kg by gavage) immediately prior to 1 h access to a fixed amount of food.
Any parts of Cynara scolymus flowering head extract with a lack of any fiber content have been excluded.
According to the results taken at 60, 120, and 360 min after food presentation, intake of Cynara scolymus flowering head extract showed a significant decrease in postprandial glycemia in both rat groups.
The exclusion of the parts of Cynara scolymus flowering head extract with lack of any fiber content have excluded in the study suggested that the preparation induced a hyperglycemic effect without involving the fiber which has been found to process a strong impact in the inhibitory activity.
Dr. Fantini N, the lead scientist wrote in the final report, "The results obtained constitute the first evidence of a hypoglycemic effect of an artichoke preparation in laboratory rodents and confirm previous observations made in humans".
In order to reveal more information about artichoke-inhibited hyperglycemic properties, researchers evaluated the extract from Phaseolus vulgaris and Cynara scolymus and their combination on food intake and glycemia in rats.
The combination produced comparable reductions in intake of regular food and chocolate-flavored beverage, compared to a low and ineffective single use of either extract.
Furthermore, P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on the glycemic rise.
These results of the mixture of P. vulgaris and C. scolymus extracts were attributed to the efficacy of the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts.
The findings strongly suggested that artichokes may play an important role in stimulating the mixture of antihyperglycemic activity.
Based on the results, researchers wrote, after taking into account co and confounders, "These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field".
Taken altogether, artichoke used alone or combined with other herbal medicine may be considered a functional remedy for the prevention and treatment of hyperglycemia, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats by Fantini N1, Colombo G, Giori A, Riva A, Morazzoni P, Bombardelli E, Carai MA. (PubMed)
(2) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymusextracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
Saturday, 12 August 2023
#Emodin Found in Herbal Cascara Sagrada inhbits 11beta-HSD1 Associated with Insulin Resistance in Type 1 Diabetes, According to Studies
Kyle J. Norton
Herbal Cascara sagrada may process a strong and positive effect on reducing the risk and treatment of type 2 diabetes, according to studies.
Diabetes is a condition characterized by insulin resistance and abnormally high blood glucose. Most cases of type 2 diabetes are associated with insufficient insulin entering the bloodstream to regulate the glucose, caused by either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Family history, ethnicity, impaired glucose tolerance or impaired fasting glucose, high blood cholesterol, and fasting glucose overweight or obese are some prevalent risk factors of the disease, according to epidemiological studies.
Women, having gestational diabetes and polycystic ovary syndrome are also at a higher risk of diabetes.
Some researchers also suggested that aging also plays a critical role in inducing the onset of the disease, therefore, anyone over the age of 40 should be tested for diabetes every three years.
The Diabetes Society of Canada went one step further to suggest that anyone who has one or more risk factors should be tested more frequently and/or start regular screening earlier.
Truly, the clinical features of elderly diabetes are significant differences, compared to that of younger age population. Dr. Katarzyna Mordarska, the lead scientist said, "The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycemia follow deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopenia".
And, "Diabetes in elderly people is often diagnosed with a delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycemia. Elderly people are more exposed to diabetes complications, have more risk of myocardial infarction and end-stage renal disease, and are hospitalized more often due to hypoglycemia than are younger patients"
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, its bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding natural products for the treatment of type 2 diabetes investigated the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada.
Emodin enhanced GLUT4 translocation and [(14)C] function in facilitating the transport of glucose across the plasma membrane of the myotube in an AMPK-dependent manner.
Where 5' AMP-activated protein kinase or AMPK is an enzyme (EC 2.7.11.31) that plays a role in activating the glucose and fatty acid uptake.
Furthermore, emodin also inhibited glucose production by suppressing the expression genes associated with key gluconeogenesis in generating glucose through sources other than carbohydrates, such as lactate, glycerol, and glucogenic amino acids.
In C57Bl/6J mice, a single dose of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance.
According to the insulin tolerance test, the administration of emodin also increased insulin sensitivity after daily injection for 8 days.
Dr. the lead scientists said, "Emodin regulates glucose homeostasis in vivo by AMPK activation and that this may represent a novel therapeutic principle in the treatment of type 2 diabetic models".
In order to reveal more information about the anti-diabetes of emodin, researchers investigated the effects of emodin on 11beta-HSD1 and its ability to ameliorate metabolic disorders in diet-induced obese (DIO) mice.
Where 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target for type 2 diabetes and metabolic syndrome.
Emodin exerted its potency as an 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively.
Single oral administration of emodin inhibited the 11beta-HSD1 activity of liver and fat significantly in mice.
Emodin reversed prednisone-induced insulin resistance in mice, without affecting the effect of dexamethasone-induced insulin resistance, by inhibiting the 11beta-HSD1 in vivo.
In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose.
The findings suggested that emodin processes the potential value for the treatment of metabolic syndrome or type 2 diabetes.
Taken altogether, herbal Cascara Sagrada with a high amount of emodin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299
References
(1) Emodin regulates glucose utilization by activating AMP-activated protein kinase by Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH.(PubMed)
(2) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity by Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. (PubMed)
(3) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(4) Diabetes in the elderly by Katarzyna Mordarska
1 and Małgorzata Godziejewska-Zawada. (PMC)
Herbal Cascara sagrada may process a strong and positive effect on reducing the risk and treatment of type 2 diabetes, according to studies.
Diabetes is a condition characterized by insulin resistance and abnormally high blood glucose. Most cases of type 2 diabetes are associated with insufficient insulin entering the bloodstream to regulate the glucose, caused by either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Family history, ethnicity, impaired glucose tolerance or impaired fasting glucose, high blood cholesterol, and fasting glucose overweight or obese are some prevalent risk factors of the disease, according to epidemiological studies.
Women, having gestational diabetes and polycystic ovary syndrome are also at a higher risk of diabetes.
Some researchers also suggested that aging also plays a critical role in inducing the onset of the disease, therefore, anyone over the age of 40 should be tested for diabetes every three years.
The Diabetes Society of Canada went one step further to suggest that anyone who has one or more risk factors should be tested more frequently and/or start regular screening earlier.
Truly, the clinical features of elderly diabetes are significant differences, compared to that of younger age population. Dr. Katarzyna Mordarska, the lead scientist said, "The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycemia follow deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopenia".
And, "Diabetes in elderly people is often diagnosed with a delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycemia. Elderly people are more exposed to diabetes complications, have more risk of myocardial infarction and end-stage renal disease, and are hospitalized more often due to hypoglycemia than are younger patients"
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, its bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding natural products for the treatment of type 2 diabetes investigated the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada.
Emodin enhanced GLUT4 translocation and [(14)C] function in facilitating the transport of glucose across the plasma membrane of the myotube in an AMPK-dependent manner.
Where 5' AMP-activated protein kinase or AMPK is an enzyme (EC 2.7.11.31) that plays a role in activating the glucose and fatty acid uptake.
Furthermore, emodin also inhibited glucose production by suppressing the expression genes associated with key gluconeogenesis in generating glucose through sources other than carbohydrates, such as lactate, glycerol, and glucogenic amino acids.
In C57Bl/6J mice, a single dose of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance.
According to the insulin tolerance test, the administration of emodin also increased insulin sensitivity after daily injection for 8 days.
Dr. the lead scientists said, "Emodin regulates glucose homeostasis in vivo by AMPK activation and that this may represent a novel therapeutic principle in the treatment of type 2 diabetic models".
In order to reveal more information about the anti-diabetes of emodin, researchers investigated the effects of emodin on 11beta-HSD1 and its ability to ameliorate metabolic disorders in diet-induced obese (DIO) mice.
Where 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target for type 2 diabetes and metabolic syndrome.
Emodin exerted its potency as an 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively.
Single oral administration of emodin inhibited the 11beta-HSD1 activity of liver and fat significantly in mice.
Emodin reversed prednisone-induced insulin resistance in mice, without affecting the effect of dexamethasone-induced insulin resistance, by inhibiting the 11beta-HSD1 in vivo.
In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose.
The findings suggested that emodin processes the potential value for the treatment of metabolic syndrome or type 2 diabetes.
Taken altogether, herbal Cascara Sagrada with a high amount of emodin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299
References
(1) Emodin regulates glucose utilization by activating AMP-activated protein kinase by Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH.(PubMed)
(2) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity by Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. (PubMed)
(3) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(4) Diabetes in the elderly by Katarzyna Mordarska
1 and Małgorzata Godziejewska-Zawada. (PMC)Tuesday, 8 August 2023
#Cucumber's Aqueous #Extract Improves Symptoms in Patients with #Osteoarthritis by Inhibiting the Production of Pro-Inflammatory Cytokines
Kyle J. Norton
Osteoarthritis (OA) is an inflammatory disease mostly caused by work-related occupations and the working environment, affecting the muscles, joints, tendons, ligaments, and nerves, over time.
The disease is most prevalent in the US. Approximately 10% of men and 13% of women over the age of 60 years suffer from the condition.
In the general population, OA affects over 25 million people in the United States alone.
And, the numbers are increasing at an alarming rate due to the aging of the population and the obesity epidemic.
The most common symptoms of OA include pain in the joint(s), reduced movement of the joint(s), joint(s) tenderness, and stiffness, particularly, the loss of flexibility and bone spurs.
If you have experienced some of the symptoms that do not get better in a short period of time, you may have OA.
Believe it or not, patients with OA are associated with the complications of a rapid, complete breakdown of cartilage, bone death (osteonecrosis), and stress fractures.
As of today, there is no cure for the condition, Treatment of OA conventionally are focusing on reducing the pain and progression of the disease and improving quality of life.
If you are taking medication for the treatment of OA, please make sure that you know all the side effects
Prolonged use of Acetaminophen has been found to cause liver damage.
In the prevention and management of OA, some researchers suggested
* Prevented recurrent injury to damaged menisci
The meniscus is an important issue because if its function in shock absorption and load distribution in the healthy knee joint(111). A meniscal tear can lead to knee osteoarthritis (OA), but knee OA can also lead to a spontaneous breakdown of meniscal tear and damage to meniscal structure(112). Meniscus damage or recurrent injury might be considered as a signifying feature of incipient OA in middle-aged and elderly people(113).
*. Take precautions if your occupation is at increased risk of osteoarthritis
Osteoarthritis (OA) is one of the most important diseases as it frequently affects the active age group of the population contributing to the loss of working hours and of disability(114)(115)(117). Compressive, torsional, pulling and angular movements common in certain occupations or sports may result in injuries of soft tissue, thus increasing the development of OA(116).
* Muscle strengthening and aerobic exercises
Enhanced muscle strengthening with neuromuscular electrical stimulation(118), aerobic exercises(119), and exercise(220) are effective in reducing pain and improving physical function in patients with mild to moderate OA of the knee(220).
* Maintain a healthy weight(117)
Increased BMI and obesity are associated with more severe cartilage degeneration(121)(123) as assessed by both morphological and quantitative MRI measurements(122).
*Avoid dehydration
Dehydration has shown to reduce the mobility of collagen amino acid residues and carbon sugar ring structures in glycosaminoglycans, according to University of Michigan(124) of that may affect the functions of cartilage and induce the risk of OA(125), but dehydration effects are reversible, through the restoration of molecular structure and mobility(124).
* Avoid intake of inflammatory foods
Loading up on junk foods and fast foods contains a high amount of trans fat that increases the risk of inflammation(126) exhibits pro-inflammatory effects(127) and causes of osteoarthritis (OA)(128). Red meat, eggs, and wheat products all contain a high amount of arachidonic acid, too much arachidonic acid maybe worsen the inflammation process(129), etc.
* Eat your fruits and vegetables
Fruits and vegetables containing high amounts of nutrients and antioxidants (130), can enhance the immune defense system(131)within the joint through direct influences of transferrin performance for reduction of inflammation(131)(132) as well as suppressing free radicals and the chain of free radicals reaction cause of elevating the swelling and promoting degeneration(133)(134).
* Replace regular beverage with green tea
Epigallocatechin-3-gallate, a green tea polyphenol(135)(136), was found to be effective in reducing inflammatory cytokines-induced inflammatory diseases(137)(138).
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
In finding a natural compound for the treatment of osteoarthritis (OA), age-related disease researchers examined an aqueous extract of Cucumis sativus (cucumber; CSE) against GC in the management of moderate knee OA.
The randomized double-blind, parallel-group clinical trial included 122 patients (56 males and 66 females) aged between 40 and 75 years with moderate knee OA took place in three different centers
Participants were divided evenly into 2 groups (n= 61) the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally 10 mg twice daily of CSE in a 180-day intervention.
According to the results from the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), the WOMAC score of the CSE group decreased by 22.44% and 70.29% on Days 30 and 180, respectively, compared to 14.80% and 32.81% decrease in the GC group.
Similarly, the GC also showed a decrease in pain score compared to the CSE group without inducing any adverse effect.
Based on the finding, researchers said, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".
In order to reveal additional information about the anti-inflammatory properties of cucumber, researchers examined the antioxidant effect on cucurbitacins (Cub), a major compound found in the fruit.
Compared to grape-seed extract, wheat, alfalfa, and ginkgo biloba extracts, CuB showed a broad spectrum radical-scavenging capacity.
CuB exerted a similar activity to that of the aforementioned study by inhibiting the expression of TNF in macrophages and lymphocytes and the expression of pro-inflammatory mediators such as nitric-oxide synthase-2 and cyclooxygenase-2.
Collectively, Dr. Adebowale Bernard Saba, the lead scientist wrote," It is general knowledge among researchers working with natural medicinal products that any of the cucurbitacins have the attributes or the potential to become fully patented as anti-inflammatory...drug".
Taken together, cucumber processed abundantly amount of CuB may be used for the treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Search for a novel antioxidant, anti-inflammatory/analgesic, or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba and Olayinka Oridupa. (Research Gate)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Do and Do not’s List by Kyle J. Norton.
Osteoarthritis (OA) is an inflammatory disease mostly caused by work-related occupations and the working environment, affecting the muscles, joints, tendons, ligaments, and nerves, over time.
The disease is most prevalent in the US. Approximately 10% of men and 13% of women over the age of 60 years suffer from the condition.
In the general population, OA affects over 25 million people in the United States alone.
And, the numbers are increasing at an alarming rate due to the aging of the population and the obesity epidemic.
The most common symptoms of OA include pain in the joint(s), reduced movement of the joint(s), joint(s) tenderness, and stiffness, particularly, the loss of flexibility and bone spurs.
If you have experienced some of the symptoms that do not get better in a short period of time, you may have OA.
Believe it or not, patients with OA are associated with the complications of a rapid, complete breakdown of cartilage, bone death (osteonecrosis), and stress fractures.
As of today, there is no cure for the condition, Treatment of OA conventionally are focusing on reducing the pain and progression of the disease and improving quality of life.
If you are taking medication for the treatment of OA, please make sure that you know all the side effects
Prolonged use of Acetaminophen has been found to cause liver damage.
In the prevention and management of OA, some researchers suggested
* Prevented recurrent injury to damaged menisci
The meniscus is an important issue because if its function in shock absorption and load distribution in the healthy knee joint(111). A meniscal tear can lead to knee osteoarthritis (OA), but knee OA can also lead to a spontaneous breakdown of meniscal tear and damage to meniscal structure(112). Meniscus damage or recurrent injury might be considered as a signifying feature of incipient OA in middle-aged and elderly people(113).
*. Take precautions if your occupation is at increased risk of osteoarthritis
Osteoarthritis (OA) is one of the most important diseases as it frequently affects the active age group of the population contributing to the loss of working hours and of disability(114)(115)(117). Compressive, torsional, pulling and angular movements common in certain occupations or sports may result in injuries of soft tissue, thus increasing the development of OA(116).
* Muscle strengthening and aerobic exercises
Enhanced muscle strengthening with neuromuscular electrical stimulation(118), aerobic exercises(119), and exercise(220) are effective in reducing pain and improving physical function in patients with mild to moderate OA of the knee(220).
* Maintain a healthy weight(117)
Increased BMI and obesity are associated with more severe cartilage degeneration(121)(123) as assessed by both morphological and quantitative MRI measurements(122).
*Avoid dehydration
Dehydration has shown to reduce the mobility of collagen amino acid residues and carbon sugar ring structures in glycosaminoglycans, according to University of Michigan(124) of that may affect the functions of cartilage and induce the risk of OA(125), but dehydration effects are reversible, through the restoration of molecular structure and mobility(124).
* Avoid intake of inflammatory foods
Loading up on junk foods and fast foods contains a high amount of trans fat that increases the risk of inflammation(126) exhibits pro-inflammatory effects(127) and causes of osteoarthritis (OA)(128). Red meat, eggs, and wheat products all contain a high amount of arachidonic acid, too much arachidonic acid maybe worsen the inflammation process(129), etc.
* Eat your fruits and vegetables
Fruits and vegetables containing high amounts of nutrients and antioxidants (130), can enhance the immune defense system(131)within the joint through direct influences of transferrin performance for reduction of inflammation(131)(132) as well as suppressing free radicals and the chain of free radicals reaction cause of elevating the swelling and promoting degeneration(133)(134).
* Replace regular beverage with green tea
Epigallocatechin-3-gallate, a green tea polyphenol(135)(136), was found to be effective in reducing inflammatory cytokines-induced inflammatory diseases(137)(138).
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
In finding a natural compound for the treatment of osteoarthritis (OA), age-related disease researchers examined an aqueous extract of Cucumis sativus (cucumber; CSE) against GC in the management of moderate knee OA.
The randomized double-blind, parallel-group clinical trial included 122 patients (56 males and 66 females) aged between 40 and 75 years with moderate knee OA took place in three different centers
Participants were divided evenly into 2 groups (n= 61) the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally 10 mg twice daily of CSE in a 180-day intervention.
According to the results from the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), the WOMAC score of the CSE group decreased by 22.44% and 70.29% on Days 30 and 180, respectively, compared to 14.80% and 32.81% decrease in the GC group.
Similarly, the GC also showed a decrease in pain score compared to the CSE group without inducing any adverse effect.
Based on the finding, researchers said, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".
In order to reveal additional information about the anti-inflammatory properties of cucumber, researchers examined the antioxidant effect on cucurbitacins (Cub), a major compound found in the fruit.
Compared to grape-seed extract, wheat, alfalfa, and ginkgo biloba extracts, CuB showed a broad spectrum radical-scavenging capacity.
CuB exerted a similar activity to that of the aforementioned study by inhibiting the expression of TNF in macrophages and lymphocytes and the expression of pro-inflammatory mediators such as nitric-oxide synthase-2 and cyclooxygenase-2.
Collectively, Dr. Adebowale Bernard Saba, the lead scientist wrote," It is general knowledge among researchers working with natural medicinal products that any of the cucurbitacins have the attributes or the potential to become fully patented as anti-inflammatory...drug".
Taken together, cucumber processed abundantly amount of CuB may be used for the treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Search for a novel antioxidant, anti-inflammatory/analgesic, or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba and Olayinka Oridupa. (Research Gate)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Do and Do not’s List by Kyle J. Norton.
#Chastetreeberry is Comparable to #Bromocriptine for Reducing Serum Prolactin Levels and Ameliorating Cyclic Mastalgia, According to Studies
Kyle J. Norton
Hyperprolinemia is a condition characterized by overexpression of the level of prolactin in the blood produced by the lactotroph cells of the anterior pituitary gland.
Normally, the expression of the hormone prolactin is to enhance breast development during pregnancy and to induce lactation.
In non-pregnant women, elevated levels of prolactin can disrupt the normal menstrual period in women, causing the complication of infertility, abnormal lactation, amenorrhea, irregular periods, breast pain, and painful sexual intercourse.
The most common cause of the onset of hyperlactatemia is the result of the growth of a tumor on the pituitary gland. Most cases of the pituitary gland are noninvasive, however, if the tumor is growing large enough, it can suppress the nearby nerve cells, causing headaches and vision problems.
Some researchers suggested the syndrome can also be caused by long-term use of certain medications.
Dr. Daria La Torre, the lead author in the study "Pharmacological causes of hyperprolactinemia" said, "Several drugs may determine a significant increase in prolactin serum concentration that is frequently associated with symptoms. The so-called typical antipsychotics are frequently responsible for drug-related hyperprolactinemia"
And, "Risperidone is one of the atypical neuroleptics most likely to induce hyperprolactinemia, while other atypical drugs are infrequently and only transiently associated with increase of prolactin levels" and "Antidepressant drugs with serotoninergic activity, including selective serotonin reuptake inhibitors (SSRI), monoamine oxidase inhibitors (MAO-I) and some tricyclics, can cause hyperprolactinemia.".
Therefore, if you are taking the above medication, please make sure you discuss the problem with your doctor.
In fact, some women experience the syndrome of hyperprolactinemia with unknown causes.
The most common conventional treatment targets the symptoms and reduces the size of the tumor. The unknown causes of hyperprolactinemia are treated with synthetic thyroid hormone.
Medication used for the treatment of hyperprolactinemia includes Medical treatment of dopamine agonists (DA): bromocriptine, lisuride, quinagolide, and cabergoline. And in over 80% of cases, these drugs induce normal prolactinoma and ovulatory cycles.
If you are taking one of these medications for the treatment of hyperprolactinemia, please make you know all the side effects
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,.
The plant has been used in herbal medicine for thousands of years as an anaphrodisiac herb and is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time.
There was a report that chaste tree berry stems and leaves were used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria.
With an aim to reaffirm the traditional use of Vitex agnus-castus L. (chaste tree; chaste berry for the treatment of a range of female reproductive conditions in Anglo-American and European practice, researchers at the Royal Melbourne Institute of Technology-University conducted an experiment to examine the effect of the herbal medicine in women with premenstrual syndrome, premenstrual dysphoric disorder, and latent hyperprolactinemia.
The search based on the Cochrane risk of bias and Jadad scales on the database of medical literature identifies 13 Thirteen randomized, controlled trials and twelve are included in this review, of which eight investigated premenstrual syndrome, two premenstrual dysphoric disorder, and two latent hyperprolactinemia.
Application of the Vitex agnus-castus in latent hyperprolactinemia suggested that the herbal medicine is superior compared to placebo for reducing TRH-stimulated prolactin secretion, normalizing a shortened luteal phase, increasing mid-luteal progesterone and 17β-oestradiol levels.
And Vitex is comparable to bromocriptine for reducing serum prolactin levels and ameliorating cyclic mastalgia. Adverse events with Vitex were mild and generally infrequent.
These results indicated, Vitex extracts in the treatment of premenstrual syndrome, premenstrual dysphoric disorder, and latent hyperprolactinemia.
Furthermore, Dr, Milewicz A, in the finding natural medicine with no side effect in the treatment of hyperprolactinemia conducted a randomized double-blind study vs. placebo to evaluate the efficacy of a Vitex agnus castus preparation (Strotan capsules) vs. placebo.
The clinical study involved 52 women with luteal phase defects due to latent hyperprolactinemia.
The participants were given a daily dose of one capsule (20 mg) of Vitex agnus castus preparation and a placebo.
In the assessment of the blood for hormonal analysis taken at days 5-8 and day 20 of the menstrual cycle before and after three months of therapy.
Women who received the Vitex agnus castus preparation showed a reduction of prolactin release after 3 months.
The shortened luteal phases of these women were normalized and deficits in the luteal progesterone synthesis were eliminated.
These changes were significant and occurred only in the Vitex group.
Side effects were not seen during the experiment and two women treated with the Vitex agnus castus preparation got pregnant.
Taken together, Chaste tree berry (Vitex agnus-castus) may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of hyperprolactinemia
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources(1) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(2) [Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study].[Article in German] by Milewicz A1, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, Schmitz H.(PubMed)
(3) Pharmacological causes of hyperprolactinemia by bDaria La Torre and Alberto Falorni. (PMC)
Hyperprolinemia is a condition characterized by overexpression of the level of prolactin in the blood produced by the lactotroph cells of the anterior pituitary gland.
Normally, the expression of the hormone prolactin is to enhance breast development during pregnancy and to induce lactation.
In non-pregnant women, elevated levels of prolactin can disrupt the normal menstrual period in women, causing the complication of infertility, abnormal lactation, amenorrhea, irregular periods, breast pain, and painful sexual intercourse.
The most common cause of the onset of hyperlactatemia is the result of the growth of a tumor on the pituitary gland. Most cases of the pituitary gland are noninvasive, however, if the tumor is growing large enough, it can suppress the nearby nerve cells, causing headaches and vision problems.
Some researchers suggested the syndrome can also be caused by long-term use of certain medications.
Dr. Daria La Torre, the lead author in the study "Pharmacological causes of hyperprolactinemia" said, "Several drugs may determine a significant increase in prolactin serum concentration that is frequently associated with symptoms. The so-called typical antipsychotics are frequently responsible for drug-related hyperprolactinemia"
And, "Risperidone is one of the atypical neuroleptics most likely to induce hyperprolactinemia, while other atypical drugs are infrequently and only transiently associated with increase of prolactin levels" and "Antidepressant drugs with serotoninergic activity, including selective serotonin reuptake inhibitors (SSRI), monoamine oxidase inhibitors (MAO-I) and some tricyclics, can cause hyperprolactinemia.".
Therefore, if you are taking the above medication, please make sure you discuss the problem with your doctor.
In fact, some women experience the syndrome of hyperprolactinemia with unknown causes.
The most common conventional treatment targets the symptoms and reduces the size of the tumor. The unknown causes of hyperprolactinemia are treated with synthetic thyroid hormone.
Medication used for the treatment of hyperprolactinemia includes Medical treatment of dopamine agonists (DA): bromocriptine, lisuride, quinagolide, and cabergoline. And in over 80% of cases, these drugs induce normal prolactinoma and ovulatory cycles.
If you are taking one of these medications for the treatment of hyperprolactinemia, please make you know all the side effects
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,.
The plant has been used in herbal medicine for thousands of years as an anaphrodisiac herb and is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time.
There was a report that chaste tree berry stems and leaves were used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria.
With an aim to reaffirm the traditional use of Vitex agnus-castus L. (chaste tree; chaste berry for the treatment of a range of female reproductive conditions in Anglo-American and European practice, researchers at the Royal Melbourne Institute of Technology-University conducted an experiment to examine the effect of the herbal medicine in women with premenstrual syndrome, premenstrual dysphoric disorder, and latent hyperprolactinemia.
The search based on the Cochrane risk of bias and Jadad scales on the database of medical literature identifies 13 Thirteen randomized, controlled trials and twelve are included in this review, of which eight investigated premenstrual syndrome, two premenstrual dysphoric disorder, and two latent hyperprolactinemia.
Application of the Vitex agnus-castus in latent hyperprolactinemia suggested that the herbal medicine is superior compared to placebo for reducing TRH-stimulated prolactin secretion, normalizing a shortened luteal phase, increasing mid-luteal progesterone and 17β-oestradiol levels.
And Vitex is comparable to bromocriptine for reducing serum prolactin levels and ameliorating cyclic mastalgia. Adverse events with Vitex were mild and generally infrequent.
These results indicated, Vitex extracts in the treatment of premenstrual syndrome, premenstrual dysphoric disorder, and latent hyperprolactinemia.
Furthermore, Dr, Milewicz A, in the finding natural medicine with no side effect in the treatment of hyperprolactinemia conducted a randomized double-blind study vs. placebo to evaluate the efficacy of a Vitex agnus castus preparation (Strotan capsules) vs. placebo.
The clinical study involved 52 women with luteal phase defects due to latent hyperprolactinemia.
The participants were given a daily dose of one capsule (20 mg) of Vitex agnus castus preparation and a placebo.
In the assessment of the blood for hormonal analysis taken at days 5-8 and day 20 of the menstrual cycle before and after three months of therapy.
Women who received the Vitex agnus castus preparation showed a reduction of prolactin release after 3 months.
The shortened luteal phases of these women were normalized and deficits in the luteal progesterone synthesis were eliminated.
These changes were significant and occurred only in the Vitex group.
Side effects were not seen during the experiment and two women treated with the Vitex agnus castus preparation got pregnant.
Taken together, Chaste tree berry (Vitex agnus-castus) may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of hyperprolactinemia
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources(1) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(2) [Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study].[Article in German] by Milewicz A1, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, Schmitz H.(PubMed)
(3) Pharmacological causes of hyperprolactinemia by bDaria La Torre and Alberto Falorni. (PMC)
#Emodin Isolated from Herbal #CascaraSagrada Inhibits the Infection Induced by #HerpesSimplexVirus, Scientists Say
Kyle J. Norton
Herbal Cascara Sagrada may process a bioactive compound for the prevention and treatment of Herpes simplex virus (HSV) infection, according to studies.
Herpes simplex virus (HSV) belonging to the human Herpesviridae family is a class of viruses that cause viral infections in the majority of humans.
The herpes simplex virus (HSV) is very contagious.
Diseases associated with the infection of herpes simplex viruses 1 include the skin, mouth, lips, eyes, and genitals. In severe cases, the viruses also cause encephalitis, meningitis, and neonatal herpes.
HSV-2 usually causes genital lesions.
Ethnicity, gender, increase in age, sex without a condom, and people with HIV infection weakened immune system and are at a higher risk of HSV infection, particularly in people with certain sexual behavior.
Dr. Kalu E, the lead scientist at the Umuahia, Abia State in the concern of the sexual behavior in risk of HSV infection wrote, "Seroprevalence of HSV-2 antibody was 47.3%." and "Sexual behavioral factors that were significantly associated with HSV-2 seroprevalence included early exposure to sexual intercourse, number of sex partners, involvement in polygamous marriages, the involvement of husband in extra-marital affairs and hormonal contraceptive use".
The cross-sectional study design was adopted and the study took place between November 2011 and June 2012 with the participation of 410 consenting ante-natal clinic patients in two major tertiary hospitals in Benin City.
The finding clearly suggested that certain sexual behaviors are associated with the risk of Herpes simplex virus 1 (HSV1) infection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, its bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
Researchers on the finding a natural product with no side effects for the treatment of Herpes simplex viruses (HSV-1 and -2), in the induction of AIDs, evaluated the effects of emodin, the major compound of Rheum tanguticum and Herbal Cascara Sagrada anti-HSV activity.
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) used in the study was obtained by extracting and purifying from herbal medicine.
The study was carried out In Vivo with the HSV-infected mice orally administered with emodin beginning at 24 h post-HSV exposures with dosages of 3.3 g/kg/day, 6.7 g/kg/day, and 11.3 g/kg/day, respectively, for 7 days.
During the experiment, the injection of emodin displayed significant inhibition of the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50 μg/ml with an antiviral index of 2.07 and 3.53, respectively.
Emodin treatment increased the survival rate of HSV-infected mice, prolonged survival time, and showed higher efficacy of HSV elimination from the brain, heart, liver, and ganglion, compared to the viral controls.
Furthermore, the efficacy of emodin was found to exert a similar inhibition compared to that of conventional medicine, acyclovir.
Dr. Xiong HR and colleagues wrote in the final report, "Emodin has the anti-HSV activity in vitro and in vivo and is thus a promising agent in the clinical therapy of HSV infection".
Moreover, in order to reveal more information about the anti-herpes simplex virus activity of emodin, researchers examined the effect of the phytochemical compared to a small group of nucleoside analogs that target the viral polymerase.
Emodin specifically inhibited the nuclease activity of HSV-1 UL12 alkaline nuclease which plays a critical role in viral DNA replication, similar to that of nucleoside analogs, according to the biochemical assay.
Emodin reduced plaque formation or cell-to-cell spread, with an EC(50) of 21.5+/-4.4 muM, according to the plaque reduction assay.
Additionally, according to the docking analysis, the inhibitory effect of emodin on the UL12 activity also was associated with the interaction between emodin and critical catalytic amino acid residues of UL12 similar to that of nucleoside analogs.
Taken altogether, herbal Cascara Sagrada processed abundantly bioactive compound emodin may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of HSV-1 and -2 infections, pending the reconfirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo by Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ.(PubMed)
(2) Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures by Hsiang CY, Ho TY.(PubMed)
(3) Sexual behavioral correlates with HSV-2 seroprevalence among pregnant women in Nigeria by Kalu EI1, Ojide CK, Fowotade A, Nwadike VU. (PubMed)
Herbal Cascara Sagrada may process a bioactive compound for the prevention and treatment of Herpes simplex virus (HSV) infection, according to studies.
Herpes simplex virus (HSV) belonging to the human Herpesviridae family is a class of viruses that cause viral infections in the majority of humans.
The herpes simplex virus (HSV) is very contagious.
Diseases associated with the infection of herpes simplex viruses 1 include the skin, mouth, lips, eyes, and genitals. In severe cases, the viruses also cause encephalitis, meningitis, and neonatal herpes.
HSV-2 usually causes genital lesions.
Ethnicity, gender, increase in age, sex without a condom, and people with HIV infection weakened immune system and are at a higher risk of HSV infection, particularly in people with certain sexual behavior.
Dr. Kalu E, the lead scientist at the Umuahia, Abia State in the concern of the sexual behavior in risk of HSV infection wrote, "Seroprevalence of HSV-2 antibody was 47.3%." and "Sexual behavioral factors that were significantly associated with HSV-2 seroprevalence included early exposure to sexual intercourse, number of sex partners, involvement in polygamous marriages, the involvement of husband in extra-marital affairs and hormonal contraceptive use".
The cross-sectional study design was adopted and the study took place between November 2011 and June 2012 with the participation of 410 consenting ante-natal clinic patients in two major tertiary hospitals in Benin City.
The finding clearly suggested that certain sexual behaviors are associated with the risk of Herpes simplex virus 1 (HSV1) infection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, its bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
Researchers on the finding a natural product with no side effects for the treatment of Herpes simplex viruses (HSV-1 and -2), in the induction of AIDs, evaluated the effects of emodin, the major compound of Rheum tanguticum and Herbal Cascara Sagrada anti-HSV activity.
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) used in the study was obtained by extracting and purifying from herbal medicine.
The study was carried out In Vivo with the HSV-infected mice orally administered with emodin beginning at 24 h post-HSV exposures with dosages of 3.3 g/kg/day, 6.7 g/kg/day, and 11.3 g/kg/day, respectively, for 7 days.
During the experiment, the injection of emodin displayed significant inhibition of the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50 μg/ml with an antiviral index of 2.07 and 3.53, respectively.
Emodin treatment increased the survival rate of HSV-infected mice, prolonged survival time, and showed higher efficacy of HSV elimination from the brain, heart, liver, and ganglion, compared to the viral controls.
Furthermore, the efficacy of emodin was found to exert a similar inhibition compared to that of conventional medicine, acyclovir.
Dr. Xiong HR and colleagues wrote in the final report, "Emodin has the anti-HSV activity in vitro and in vivo and is thus a promising agent in the clinical therapy of HSV infection".
Moreover, in order to reveal more information about the anti-herpes simplex virus activity of emodin, researchers examined the effect of the phytochemical compared to a small group of nucleoside analogs that target the viral polymerase.
Emodin specifically inhibited the nuclease activity of HSV-1 UL12 alkaline nuclease which plays a critical role in viral DNA replication, similar to that of nucleoside analogs, according to the biochemical assay.
Emodin reduced plaque formation or cell-to-cell spread, with an EC(50) of 21.5+/-4.4 muM, according to the plaque reduction assay.
Additionally, according to the docking analysis, the inhibitory effect of emodin on the UL12 activity also was associated with the interaction between emodin and critical catalytic amino acid residues of UL12 similar to that of nucleoside analogs.
Taken altogether, herbal Cascara Sagrada processed abundantly bioactive compound emodin may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of HSV-1 and -2 infections, pending the reconfirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo by Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ.(PubMed)
(2) Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures by Hsiang CY, Ho TY.(PubMed)
(3) Sexual behavioral correlates with HSV-2 seroprevalence among pregnant women in Nigeria by Kalu EI1, Ojide CK, Fowotade A, Nwadike VU. (PubMed)
#Cucurbitacin B (CuB) Isolated from #Cucumbers Exerts a Strong #Antiangiogenic and #Antimetastatic Activities, Researchers Say
Kyle J. Norton
Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.
Anti-metastasis is an action in which substances or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.
Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered process antimetastatic activity.
In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.
Angiogenesis is the process of stimulating the growth of new blood vessels from preexisting blood vessels used by the tumor to obtain nutrients in facilitating cancer proliferation.
Anti-angiogenic activity is an action in which substances such as drugs and herbal medicine are used to stop tumors from growing their own blood vessels.
Conventionally, medicines that block the block vascular endothelial growth factor (VEGF) from attaching to the receptors on the cells that line the blood vessels. such as bevacizumab (Avastin). Bevacizumab is considered anti-angiogenic drugs.
Believe it or not, as of today, there is no anti-metastatic drug on the market, even over 90 percent of cancer deaths today are due to metastasis formation. Dr. Stock AM, the lead scientist in the examined the targets for anti-metastatic drug development, wrote, "Tumor cell migration is the essential prerequisite for invasion and metastasis formation. It is regulated by signal substances in terms of the grade of activity and in terms of direction (chemotaxis)".
And, "Moreover we provide the example of beta-blockers, how established drugs in other indications are possibly effective and can be co-opted as such anti-metastatic".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
Scientists in the urgency to find the natural compound for the treatment of cancer examined the effect of Cucurbitacin B (CuB), a plant triterpenoid found abundantly in cucumber against the metastatic and angiogenic potential of breast cancer cells.
During the experiment, CuB showed significant activity in the inhibition of cellular proliferation and induction of apoptosis in the tested cancer cells in a time- and dose-dependent manner.
Furthermore, at the sub-IC50 concentrations, the injection of CuB inhibited the migratory and invasive potential of highly metastatic breast cancer MDA-MB-231 and 4T1 cells.
In HUVECs, the administration of CubB also inhibited migratory, invasive, and tube-forming capacities.
In chick embryo chorioallantoic membrane, CuB exerted a strong anti-angiogenic effect in the prevention of new blood vessels.
According to the tested assay, the efficacy of Cub antimetastatic and angiogenic properties was attributed to the blocking of the matrix and proteins (VEGF/FAK/MMP-9) in signaling the development of new blood vessels from the existing vessels to induce cancer cells proliferation.
Additionally, the anti-angiogenesis was also evidenced by the decreased protein CD31 associated with more than 90% of angiosarcomas.
Dr. Sinha S, the lead scientist said, "Collectively, our findings suggest that CuB inhibited breast cancer metastasis and angiogenesis, at least in part, through the downregulation of VEGF/FAK/MMP-9 signaling".
In non-small cell lung cancer (NSCLC) both in vitro and in vivo, at nanomolar concentrations injection of CuB demonstrated a strong anti-migratory and anti-invasive ability against metastatic NSCLC by blocking the migratory, invasive, and tube-forming capacities.
The efficacy of the tested compound in this experiment inhibited metastasis and angiogenesis was attributable to the suppression of proteins (Wnt/β-catenin) associated with passing signals into a cell through cell surface receptors to induce cell proliferation and formation of new blood vessels.
Taken together, cucumber processed with a high amount of CuB may be considered supplements for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis by Sinha S1, Khan S1, Shukla S1, Lakra AD1, Kumar S2, Das G3, Maurya R2, Meeran SM. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Targets for anti-metastatic drug development by Stock AM1, Troost G, Niggemann B, Zänker KS, Entschladen F. (PubMed)
Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.
Anti-metastasis is an action in which substances or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.
Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered process antimetastatic activity.
In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.
Angiogenesis is the process of stimulating the growth of new blood vessels from preexisting blood vessels used by the tumor to obtain nutrients in facilitating cancer proliferation.
Anti-angiogenic activity is an action in which substances such as drugs and herbal medicine are used to stop tumors from growing their own blood vessels.
Conventionally, medicines that block the block vascular endothelial growth factor (VEGF) from attaching to the receptors on the cells that line the blood vessels. such as bevacizumab (Avastin). Bevacizumab is considered anti-angiogenic drugs.
Believe it or not, as of today, there is no anti-metastatic drug on the market, even over 90 percent of cancer deaths today are due to metastasis formation. Dr. Stock AM, the lead scientist in the examined the targets for anti-metastatic drug development, wrote, "Tumor cell migration is the essential prerequisite for invasion and metastasis formation. It is regulated by signal substances in terms of the grade of activity and in terms of direction (chemotaxis)".
And, "Moreover we provide the example of beta-blockers, how established drugs in other indications are possibly effective and can be co-opted as such anti-metastatic".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
Scientists in the urgency to find the natural compound for the treatment of cancer examined the effect of Cucurbitacin B (CuB), a plant triterpenoid found abundantly in cucumber against the metastatic and angiogenic potential of breast cancer cells.
During the experiment, CuB showed significant activity in the inhibition of cellular proliferation and induction of apoptosis in the tested cancer cells in a time- and dose-dependent manner.
Furthermore, at the sub-IC50 concentrations, the injection of CuB inhibited the migratory and invasive potential of highly metastatic breast cancer MDA-MB-231 and 4T1 cells.
In HUVECs, the administration of CubB also inhibited migratory, invasive, and tube-forming capacities.
In chick embryo chorioallantoic membrane, CuB exerted a strong anti-angiogenic effect in the prevention of new blood vessels.
According to the tested assay, the efficacy of Cub antimetastatic and angiogenic properties was attributed to the blocking of the matrix and proteins (VEGF/FAK/MMP-9) in signaling the development of new blood vessels from the existing vessels to induce cancer cells proliferation.
Additionally, the anti-angiogenesis was also evidenced by the decreased protein CD31 associated with more than 90% of angiosarcomas.
Dr. Sinha S, the lead scientist said, "Collectively, our findings suggest that CuB inhibited breast cancer metastasis and angiogenesis, at least in part, through the downregulation of VEGF/FAK/MMP-9 signaling".
In non-small cell lung cancer (NSCLC) both in vitro and in vivo, at nanomolar concentrations injection of CuB demonstrated a strong anti-migratory and anti-invasive ability against metastatic NSCLC by blocking the migratory, invasive, and tube-forming capacities.
The efficacy of the tested compound in this experiment inhibited metastasis and angiogenesis was attributable to the suppression of proteins (Wnt/β-catenin) associated with passing signals into a cell through cell surface receptors to induce cell proliferation and formation of new blood vessels.
Taken together, cucumber processed with a high amount of CuB may be considered supplements for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis by Sinha S1, Khan S1, Shukla S1, Lakra AD1, Kumar S2, Das G3, Maurya R2, Meeran SM. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Targets for anti-metastatic drug development by Stock AM1, Troost G, Niggemann B, Zänker KS, Entschladen F. (PubMed)
#Carrots Inhibit the Risk of Heavy-Metal and Chemical Toxicity, According to Studies
Kyle J. Norton
Carrots may have a profound and positive effect on expelling heavy metal and chemical toxins from our body through the gastrointestinal tract, some scientists suggested.
The digestive system, includes the salivary glands, mouth, esophagus, stomach, liver, gallbladder, pancreas, small intestine, colon, and rectum. is a system responsible for extracting the nutrients and fluids from the food intake to provide energy for the body's needs and expelling feces from the body?
Some people with the digestive problem may experience symptoms of acid reflux and GERD with burning sensation, gas, bloating, constipation, diarrhea, indigestion. In serious cases, the condition can also cause gallstones, irritable bowel syndrome, and hemorrhoids,...
Some researchers suggested that eating 7 or more serving of fruits and vegetables daily, replacing refined grain products with whole grain products, reducing intake of processed food and red meat and engaging in daily physical activity are the best to optimize the digestive health.
Including vitamin D and calcium in the diet are also helpful.
Carrot, a root vegetable with an orange color is sub-species of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
Concerns of the damage of heavy metal damage to the body, researchers at Northwest A&F University, launched an investigation to examine whether insoluble dietary fiber from carrot pomace effect in exerting the protection of the digestive tract,
Researchers found that using the ultra-micro grinding process, the insoluble dietary fiber exerts far better potential in inhibited levels of glucose-, nitrite-, and lead ion- compared to the raw insoluble dietary fiber.
Truly, the ultra-micro grinding process could significantly decrease the particle size of carrot insoluble dietary fiber and increase its Brunauer-Emmett-Teller surface area from 0.374 to 1.835 m(2) g(-1).
The method also improved the water-holding capacity, swelling capacity and oil-holding capacity increased by 62.09%, 49.25%, and 45.45%, respectively.
These may be the reasons the insoluble dietary fiber from carrot pomace treated with an ultra-micro grinding process displays a significant effect in the protection of the digestive system through absorption of the far greater level of heavy and toxic metals.
The processed application also effectively protects Caco-2 cells from lead ion damage, according to the apoptosis assessment by AO/EB, compared to the raw contents
At the concentration of 10.0 mg, carrot insoluble dietary fiber has no toxicity for Caco-2 cells, the MTT assay showed.
The results of this study highlighted the potential of the ultra-micro grinding process to produce a high added-value fiber ingredient from carrot residue with function in protecting the gastrointestinal tract against heavy and toxic chemicals.
Taken together, carrot's insoluble dietary fiber may be used as a functional food in improving digestive function by absorbing heavy and toxic chemicals before causing harm to the body tissue and organs.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Physicochemical properties and intestinal protective effect of ultra-micro ground insoluble dietary fibre from carrot pomace by Ma S1, Ren B, Diao Z, Chen Y, Qiao Q, Liu X(PubMed)
Carrots may have a profound and positive effect on expelling heavy metal and chemical toxins from our body through the gastrointestinal tract, some scientists suggested.
The digestive system, includes the salivary glands, mouth, esophagus, stomach, liver, gallbladder, pancreas, small intestine, colon, and rectum. is a system responsible for extracting the nutrients and fluids from the food intake to provide energy for the body's needs and expelling feces from the body?
Some people with the digestive problem may experience symptoms of acid reflux and GERD with burning sensation, gas, bloating, constipation, diarrhea, indigestion. In serious cases, the condition can also cause gallstones, irritable bowel syndrome, and hemorrhoids,...
Some researchers suggested that eating 7 or more serving of fruits and vegetables daily, replacing refined grain products with whole grain products, reducing intake of processed food and red meat and engaging in daily physical activity are the best to optimize the digestive health.
Including vitamin D and calcium in the diet are also helpful.
Carrot, a root vegetable with an orange color is sub-species of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
Concerns of the damage of heavy metal damage to the body, researchers at Northwest A&F University, launched an investigation to examine whether insoluble dietary fiber from carrot pomace effect in exerting the protection of the digestive tract,
Researchers found that using the ultra-micro grinding process, the insoluble dietary fiber exerts far better potential in inhibited levels of glucose-, nitrite-, and lead ion- compared to the raw insoluble dietary fiber.
Truly, the ultra-micro grinding process could significantly decrease the particle size of carrot insoluble dietary fiber and increase its Brunauer-Emmett-Teller surface area from 0.374 to 1.835 m(2) g(-1).
The method also improved the water-holding capacity, swelling capacity and oil-holding capacity increased by 62.09%, 49.25%, and 45.45%, respectively.
These may be the reasons the insoluble dietary fiber from carrot pomace treated with an ultra-micro grinding process displays a significant effect in the protection of the digestive system through absorption of the far greater level of heavy and toxic metals.
The processed application also effectively protects Caco-2 cells from lead ion damage, according to the apoptosis assessment by AO/EB, compared to the raw contents
At the concentration of 10.0 mg, carrot insoluble dietary fiber has no toxicity for Caco-2 cells, the MTT assay showed.
The results of this study highlighted the potential of the ultra-micro grinding process to produce a high added-value fiber ingredient from carrot residue with function in protecting the gastrointestinal tract against heavy and toxic chemicals.
Taken together, carrot's insoluble dietary fiber may be used as a functional food in improving digestive function by absorbing heavy and toxic chemicals before causing harm to the body tissue and organs.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Physicochemical properties and intestinal protective effect of ultra-micro ground insoluble dietary fibre from carrot pomace by Ma S1, Ren B, Diao Z, Chen Y, Qiao Q, Liu X(PubMed)
Subscribe to:
Posts (Atom)