Tuesday, 8 August 2023

#Phytochemical #AnacardicAcid in the Inhibition of Bacterial Infection, According to Studies

Kyle J. Norton

Scientists may have found a bioactive compound for the replacement of antibiotics with no side effects, some studies suggested.
Infection is a human disease characterized by the invasion of an organism that multiplied in a specific tissue or organ.

In bodily injury due to physical impact, the white blood cells of the immune first line of defense stimulate the production of proteins associated with the coagulation to cover the wound against the entrance of the microorganisms and inflammatory cytokines to kill off the infectious pathogens before they can enter the body and cause damage.

Most microorganisms were killed in the acute phase of the infection.

The infection is progressing through 5 stages, including
1. The incubation stage is a stage that microorganisms have successfully entered the host and started a period of multiplication. At this period patients do not experience any symptoms.


2. The prodromal stage, followed after the incubation period, after gaining strength in numbers and continued multiplication, the presence of the invasive pathogens is noticed by the immune system, leading to an immune system response. At this period, patients may experience symptoms of fever, pain, and swelling.

3. The stage of illness is a stage the disease is formed with signs and symptoms of the disease are most obvious and severe.

4. The stage of decline, the stage that saw the immune system has won the battle. In this stage, the number of pathogens and the signs and symptoms of illness begin to decline.

5. The stage of convalescence is a stage of recovery.

Some scientists in the study of the immune evolution suggested that the immune system is designed to kill off invasive pathogens in 3-8 weeks, otherwise, it will adapt to the change, leading to diseases associated with chronic infection.

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

With an aim to find a natural antibiotic for the replacement of conventional medicine for the prevention and treatment of microbial infection, researchers examined the anacardic acid mixture antibacterial quorum sensing (QS), which is a process of bacterial cell-cell communication that controls a large number of systems affecting pathogenicity.

An anacardic acid mixture (AAM) used in the experiment was produced by the A. astringent hexane extract (HE) in the bacterial strain Chromobacterium violaceum.

By comparing the 2 extracts, researchers found that
* HE induced a 91.6% of inhibition of the violecin production at 55 μg/mL concentration, whereas AAM showed 94% of inhibition at 166 μg/mL.

* Interestingly, both extracts were found to inhibit violacein production by affecting the viability of the bacterium.* Furthermore, AAM inhibited the substance which stimulates redox cycling in bacteria (pyocyanin 86% at 200 μg/mL) and glycolipid biosurfactants of bacterial structure (rhamnolipid, 91% at 500 μg/mL) production in a dose/response form and decreases the elastase (75% at 500 μg/mL) activity in P. aeruginosa without affecting its development.

Where violecin is a naturally-occurring bis-indole pigment with antibiotic properties produced by the bacteria.

These results indicated that Anacardic acid disrupts the quorum sensing (QS) of bacteria by inhibiting the substances which play a critical role in microbial survival in cell-cell communication.

Dr.Castillo-Juárez I, the lead scientist said, " anacardic acids mixture isolated from A. astringent demonstrated anti-QS, it could be further exploited for novel molecules to treat the emerging infections of antibiotic-resistant bacterial pathogens".

Additionally, in the evaluated new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds isolated from the bark of Amphipterygium adstringens using a bioassay-guided fractionation method, researchers showed that compounds 1-4 exhibited antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis with minimum inhibitory concentrations ranging from 7 to 104 µg mL and from 12 to 126 µg mL.

Where compounds 1-4 are 6-[16'Z-nonadecenyl]-salicylic acid (1), 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0), (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4).

Taken together, anacardic acid and its bioactive derivatives may be considered antibiotics alternative for the prevention and treatment of bacterial infection with no side effects


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Amphypterygium astringent anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa by Castillo-Juárez I, García-Contreras R, Velázquez-Guadarrama N, Soto-Hernández M, Martínez-Vázquez M. (PubMed)
(2) Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis by Rivero-Cruz BE, Esturau N, Sánchez-Nieto S, Romero I, Castillo-Juárez I, Rivero-Cruz JF.(PubMed)

#Herbal #Cinnamon Improves All Parameters Associated with the Risk of #Diabetes, Researchers Suggest

Kyle J. Norton

Cinnamon, a kitchen spice in many cultures, may have gained many believers, including medical professionals because of its anti-diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce blood sugar significantly with little or no adverse effects.

The herb has been used in herbal and traditional medicine as an anti-fungal and bacteria level to improve the reproductive organ, prevent flatulence and intestinal cramping, and treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a significant reduction of blood triglyceride levels in the low-dose group, after 3 months of oral administration(2)

Some researchers suggested that cinnamon extract may improve fasting blood glucose levels and glucose tolerance without altering insulin secretion, through lower triglyceride and increased liver glycogen content, and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed "The effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR(in the regulation of metabolism (carbohydrate, lipid, protein))-medicated glucose and lipid metabolism"(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomum cassia) indicated an improvement of glucose, insulin, cholesterol, and HbA1c(a Glucose lab test) in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose but insisted that a high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

In a randomized clinical trial in which 70 Patients with type II diabetes were assigned randomly to two groups (35 in cinnamon and 35 in the placebo group the testing of the effect of cinnamon on the glucose level in the blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

Taken together, cinnamon in a low dose may be effective in controlling the levels of blood glucose in patients with diabetes without altering the insulin level. According to DR. Georgakopoulou EA., oral intake of Cinnamon may cause Stomatitis(7), and a burning sensation in the mouth with a large amount. Traditional Chinese medicine also insisted that an overdose of cinnamon can be toxic and damage to the liver(1).


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References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)

#Broccoli's Sulforaphane (SFN) Combined with ChemoDrug #Cisplatin (CDDP) Exert a Strong Anti Cancer Activity, According to Studies

Kyle J. Norton

A chemosensitivity assay is a test that measures the number of tumor cells killed by chemotherapy.
The aim of the test is to find the best chemo drugs for the treatment of cancer.

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.

At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer not only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of the cancer.

Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.

Some cancers can be slow-growth, including prostate and colon cancer. Primary cancer at stages 0 and 1 may not induce any symptoms.

According to the statistic provided by the American Cancer Society, in the US in 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are a result from cancer.

Furthermore, in the age perspective, older adults although accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.

As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.


The 5 years survival rate is totally depending on the stage of cancer diagnosed. The early diagnosed stage has the highest survival rate compared to other later stages.

Cisplatin is a chemotherapy drug given by Sclerotherapy used in conventional medicine for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors, and neuroblastoma.

Cisplatin has been found to induce adverse effects, including nausea and vomiting, diarrhea, temporary hair loss, loss inability to taste food, dry mouth, dark urine, and decreased sweating,

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

In finding a potential chemical compound with inhibition of chemotherapy side effects and chemosensitivity, researchers compared the effect of polymeric nanoparticles utilized to co-deliver a water-soluble CDDP derivative, poly(γ,l-glutamic acid)-CDDP conjugate and a naturally occurring compound derived from broccoli, sulforaphane (SFN) on chemo drug cisplatin (CDDP).

Compared with the combinational treatment of CDDP and SFN, the nanoparticles were more effectively internalized and significantly reduced GSH content in breast cancer cells, observed by the increase of DNA-bound Pt and DNA damage-induced apoptosis.

In other words, the combination is more effective than the use of the chemo drug alone due to its ability to penetrate deeper into the cancer cells.

Furthermore, in an orthotopic breast cancer model, the nanoparticles achieved a significantly higher tumor accumulation by enhancing the permeability and retention of EPR-mediated tumor targeting and exhibited a more powerful antitumor activity.

The nano-enhanced chemotherapy also showed higher content of GSH in the liver cancer model.

Collectively, researchers said, "this sulforaphane-based nano strategy holds great promise to enhance the sensitivity and therapeutic efficacy of Pt-based chemotherapy

Taken together, broccoli processed with a high amount of sulforaphane used in a combination of chemo drugs may be considered adjunct therapy for the treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of sulforaphane in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity by Xu Y1,2,3, Han X1,2,4, Li Y1,2, Min H1, Zhao X1,2, Zhang Y1,2, Qi Y5, Shi J1,2, Qi S6, Bao Y7, Nie G. (PubMed)

3,3'-Diindolylmethane Inhibits the Pathways and Promotes Antioxidant Enzymes Associated with a Reduced Risk of #ChronicLiverDisease

Kyle J. Norton

Chronic liver diseases are a medical condition that causes reduced function of the liver. In a serious case, chronic liver disease can lead to liver failure.

In other words, chronic liver diseases are liver diseases that last more than 6 months, including liver viral inflammation, liver cirrhosis, and hepatocellular carcinoma.

The liver is a large organ in the human body that filters out the blood which comes from the intestines before passing them to other parts of the body.


The largest organ also produces cholesterol to aid digestion, build a strong cell wall and produce steroids hormones and vitamin D.

According to the statistics provided by the UK, liver diseases are ranked as the fifth most common cause of death in the UK and have a steady tendency to increase over the years.

In the US, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease which affects over 100 100 million Americans.

Non-alcoholic fatty liver disease is a medical condition that caused fat accumulated in the liver over time probably due to poor diet and physical inactivity. The disease is one of the major causes of cirrhosis associated with liver cancer and liver failure.


The most common symptoms of chronic liver disease include loss of appetite, jaundice, persistent itching, fluid buildup in the belly, vomiting blood caused by the bleeding of often from bleeding in the esophagus.


3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

With an aim to discover a potent ingredient that processes liver protective effect, researchers investigated the effect of indoles, including indole-3-carbinol (I3C) and its derivatives I3C polymerizes into 3, 3- diindolylmethane (DIM) on chronic liver disease.

In vivo and vitro, indoles showed to regulate transcriptional factors and their respective signaling pathways associated with the production of proteins involved in the pro-inflammatory expression.

Furthermore, indoles also promoted the production of antioxidant enzymes against overexpression of levels of free radicals induced oxidative stress.

Moreover, the administration of indoles in vivo and in vitro also inhibited microRNA to influence the activation, proliferation, and apoptosis of target liver cells.

In other words, indoles protect the liver integrity by modulating the enzymes involved in hepatitis viral replication, lipogenesis, and the metabolism of ethanol and some hepatotoxicity.

Additionally, the bioactive compound was also found to process immunomodulatory biofunction in improving non-alcoholic steatohepatitis.

Overall, the indole liver-protective effects were attributed to its function as anti-inflammatory cytokines and chemokines to reduce microbial-induced liver injury inhibitors.

Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".


Taken altogether, indoles, including 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered supplements for the prevention and treatment of chronic liver disease pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance by Liu Y1, She W1, Wang F1, Li J2, Wang J1, Jiang W. (PubMed)
(2) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)

Vitex Negundo, a Five-Leaved Chaste Tree Extract Processes Anti-Lipase and Anti-Propionibacterium Acne Activity, According to Studies

Kyle J. Norton

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region. It has been used in herbal medicine for thousands of years as an aphrodisiac herb and is considered as Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time. There was a report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,

Propionibacterium acne is a type of acne due to infection of aerotolerant anaerobic, Gram-positive bacterium (rod) or as a result of chronic blepharitis and endophthalmitis.

Vitex agnus-castus has long been used for the treatment of hormonally induced acne in herbal medicine(1) with mild or no adverse side effects (2). Vitex negundo, a five-leaved chaste tree extract, according to the study by The Institute of Science, India, showed significant inhibition of lipase activity and a number of P. acne(3).


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Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


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References
(1) The genus Vitex: A review by Rani A1, Sharma A2. (PubMed)
(2) Vitex agnus castus: a systematic review of adverse events by Daniele C1, Thompson Coon J, Pittler MH, Ernst E.(PubMed)
(3) Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants by Patil V1, Bandivadekar A, Debjani D.(PubMed)

#Herbal #Cinnamon and Its #EssentialOil Process a Strong Anti Fungal and Bacterial Infection Activties, According to Studies

Kyle J. Norton

The topical use of essential oil and intake of cinnamon in patients are found to express antimicrobial effects.

The essential oil found from cinnamomum zeylanicum, in influenza and post-influenza bacterial pneumonia infections resisted conventional antimicrobial agents and inhibited effectively against H1N1 and HSV1 viruses.

According to the study by the Kings and St Thomas's Hospital, natural essential oils extracted from cinnamon expressed antimicrobial activity among three oils against Escherichia coli, Staphylococcus aureus , Aspergillus oryzae , and Penicillium digitatum.

Cinnamon is a spice derived from the inner bark of the tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as an anti-fungal and bacterial levels, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

Dr. Liu Q, the lead author at the Liu Q, said," Cinnamon,... possessed significant antibacterial and antifungal activities against food spoilage bacteria like Bacillus subtilis and Pseudomonas fluorescens, pathogens like Staphylococcus aureus and Vibrio parahaemolyticus, harmful fungi like Aspergillus flavus".

In vitro, trans-cinnamaldehyde showed to inhibit Clostridium difficile infection in the spore-forming bacterium.

Cinnamon and its essential oil may be the natural agent in use for the prevention and treatment of microbial infection. Intake of whole herbs and supplements should be taken with care. Overdoses have been seen to induce toxicity.


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Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



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Sources
(1) Synergistic antimicrobial activities of natural essential oils with chitosan films by Wang L1, Liu F, Jiang Y, Chai Z, Li P, Cheng Y, Jing H, Leng X.(PubMed)
(2) Antibacterial and Antifungal Activities of Spices by Liu Q1, Meng X2, Li Y3, Zhao CN4, Tang GY5, Li HB6,7.(PubMed)
(3) Antimicrobial activity of natural products against Clostridium difficile in vitro by Roshan N1, Riley TV1,2,3,4, Hammer KA1.(PubMed)
(4) Antibacterial, antifungal, and antiviral effects of three essential oil blends by Brochot A1, Guilbot A1, Haddioui L2, Roques C2,3.(PubMed)

#CruciferousVegetables Inversely Are Associated with the Risk of Total Mortality Rate in Patients with Cardiovascular Diseases

Kyle J. Norton

A cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.

What causes plaques building up in the wall of the arteries is debatable.

Researchers do not why people who have the same health conditions, family history, and diet pattern, are susceptible to the early onset of cardiovascular disease while others do not.


According to the John Hopkins statistics, approximately 84 million people in the US suffer from some form of cardiovascular disease, causing about 2,200 deaths a day, averaging one death every 40 seconds.

Sadly to now that almost one out of every three deaths results from cardiovascular disease.

Epidemiologically, certain risk factors are found to associate with the onset of the condition, including lack of exercise, diabetes, use of tobacco, gender, genetic preposition, and excessive alcohol drinking.


One of the most common and preventable risk factors has been under intensified debate in the scientific community. If a poor diet pattern and lifestyle can facilitate the onset of the disease, then a healthy diet choice and lifestyle with moderate exercise should provide a strong effect in the prevention and treatment of cardiovascular disease.

In other words, by replacing the Western diet characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks and a dietary risk factor for CVD with the traditional diet characterized by high in fruits and vegetables and less in red meat and processed foods, cardiovascular disease is preventable.

Cardiovascular disease (CVD) is a leading disease to cause of death of 840,768 deaths (635,260 cardiac) in 2016 in the United States.


From 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

In finding a potential remedy for reducing the mortality rate of cardiovascular diseases, researchers compared cruciferous vegetables, noncruciferous vegetables, total vegetables, and total fruit intake with risk of all-cause and cause-specific mortality.


The study included a total of 134,796 Chinese adults who participated in 2 population-based, prospective cohort studies in the Shanghai Women's Health Study and the Shanghai Men's Health Study.

According to the validated food-frequency questionnaires, returned from the participants,
* Over the time of the study, 3442 deaths among women during a mean follow-up of 10.2 y and 1951 deaths among men during a mean follow-up of 4.6 y.

*Although fruit and vegetable intake was inversely associated with risk of total mortality in both women and men, and a dose-response pattern, cruciferous vegetable intake showed the most strong protective effects against mortality.

* The inverse associations of all fruits and vegetables intake primarily related only to cardiovascular disease mortality but not to cancer mortality.

Based on the results, researchers said, "Our findings support recommendations to increase consumption of vegetables, particularly cruciferous vegetables, and fruit to promote cardiovascular health and overall longevity".

Taken together, cruciferous vegetables may be considered functional remedies for the prevention of total and cardiovascular disease mortality, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality by Zhang X1, Shu XO, Xiang YB, Yang G, Li H, Gao J, Cai H, Gao YT,
Zheng W. (PubMed)