Kyle J. Norton
Kidneys are 2 bean-shaped organs found on the left and right side of the retroperitoneal space in the body.
The function of the kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.
Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.
Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.
Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.
Chemotherapy is a drug treatment that kills cancer cells by inducing cytotoxicity. Most cases of chemotherapy have been found to cause severe side effects on the patient, including fatigue, loss of appetite, nausea, bowel issues such as constipation or diarrhea, hair loss, mouth sores, skin and nail problems.
Chemo drugs have also been shown to induce nephrotoxicity, by increasing the production of ROS and inhibiting several antioxidant enzymes to orchestrate kidney oxidative stress injury.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
On finding a potential plant that processes anti-kidney toxicity induced by chemo-drugs, researchers examined the effects of sulforaphane (SF), a natural constituent of cruciferous vegetables such as broccoli, on Cisplatin (cis-diamminedichloroplatinum II, CIS) nephropathy.
In rodents, before treatment with FN, cisplatin therapy triggered marked activation of stress signaling pathways to promote cancer cell death in the kidney by increasing the DNA fragmentation, apoptotic proteins,
Furthermore, CIS also exhibited the terminal associated with attenuation of various prosurvival signaling pathways and increased levels of the pro-inflammatory cytokines in the kidney.
In other words, the injection of CIS not only induced kidney injury but also caused damage to the death of the kidney cells, through several aforementioned mechanisms.
After the administration of SF, all these effects were significantly attenuated by the pretreatment of rodents with SFN.
Based on the evidence, researchers wrote, " SFN is able to prevent the CIS-induced renal injury by modulating these pathways, providing a novel approach for preventing this devastating complication of chemotherapy".
Taken together, the consequences of these results suggest that the broccoli process the potential anti-side effect of CIS in the induction of kidney toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the KIarate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy by Guerrero-Beltrán CE1, Mukhopadhyay P, Horváth B, Rajesh M, Tapia E, García-Torres I, Pedraza-Chaverri J, Pacher P. (PubMed)
Tuesday, 8 August 2023
#Free-dried Aqueous #Extract from #Cucumber Induces Cytotoxicity in #EsophagealCancer Cells, Researchers Say
Kyle J. Norton
Esophageal cancer is a chronic medical condition that arises from the esophagus due to the alternation of cell DNA.
Most cases of esophageal cancer start in the cell on the surface of the inner lining of the esophagus between the throat and the stomach. At the early stage, due to the very small size of the tumor, most patients are asymptomatic.
As the tumor continues to grow, patients may experience symptoms of difficulty swallowing, persistent chest pain and pressure, pain-burning sensation, coughing or hoarseness, and heartburn.
If you persistently experience chronic acid reflux, accompanied by some of the aforementioned symptoms, you should check with your doctor immediately to rule out of the possibility of esophageal cancer.
Some patients may also vomit blood if the tumor has pressed onto the nearby blood vessels.
At the advanced stage, the primary cancer cell can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
According to the statistics, in the US, approximately 17,650 adults (13,750 men and 3,900 women) in the United States will be diagnosed with esophageal cancer this year, accounting for 1% of cancers diagnosed.
Although there are many risk factors associated with the onset of the disease, some researchers suggested patients with chronic gastroesophageal reflux disease (GERD) are found to have a strong implication on the disease onset.
Dr. Shaheen N, the lead scientist at the University of North Carolina-Chapel Hil, wrote, "Gastroesophageal reflux disease (GERD) is a risk factor for adenocarcinoma of the esophagus, rare cancer whose incidence is increasing".
However, "Strong evidence supports the association of GERD and adenocarcinoma of the esophagus; however, the risk of cancer in any given individual with GERD is low".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to discover a potential ingredient for the treatment of esophageal cancer, researchers investigated the possible cytotoxic effect of freeze-dried aqueous extract of E. elaterium fruit on KYSE30 (human esophageal squamous cell carcinoma).
The study included the free dried aqueous extract of the fruits of E. elaterium incubated for 24, 48, and 72 h. on KYSE30 cancer cell lines.
The extracts showed a significant effect in the inhibition of the KYSE30 cell line at IC(50) values at concentrations of 500, 150, and 125 μg/ml after 24, 48, and 72 h, respectively.
According to the EB/AO staining, the extract showed an increase in apoptotic cells of the KYSE30 cell line.
Furthermore, the free-dried aqueous extract of the fruits of E. elaterium exerted a significant increase in cell density at the G2/M phase before inducing cell cycle arrest, according to the cell cycle analysis.
Based on the findings, researchers suggested that the freeze-dried aqueous extract of E. elaterium fruit has a cytotoxic effect on esophageal cancer cell lines via the induction of apoptosis.
Dr. Bohlooli S, the lead scientist wrote, " It seems that several compounds are possibly responsible for the cytotoxic effect of the extract".
In other words, several compounds in the extract worked synergistically to exhibit cytotoxicity against the tested cancer cell line.
Taken altogether, cucumber may be considered supplements for the prevention and treatment of esophageal cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastricadenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines by Bohlooli S1, Jafari N, Jahed S. (PubMed)
(2) Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review by Shaheen N1, Ransohoff DF. (PubMed)
Esophageal cancer is a chronic medical condition that arises from the esophagus due to the alternation of cell DNA.
Most cases of esophageal cancer start in the cell on the surface of the inner lining of the esophagus between the throat and the stomach. At the early stage, due to the very small size of the tumor, most patients are asymptomatic.
As the tumor continues to grow, patients may experience symptoms of difficulty swallowing, persistent chest pain and pressure, pain-burning sensation, coughing or hoarseness, and heartburn.
If you persistently experience chronic acid reflux, accompanied by some of the aforementioned symptoms, you should check with your doctor immediately to rule out of the possibility of esophageal cancer.
Some patients may also vomit blood if the tumor has pressed onto the nearby blood vessels.
At the advanced stage, the primary cancer cell can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
According to the statistics, in the US, approximately 17,650 adults (13,750 men and 3,900 women) in the United States will be diagnosed with esophageal cancer this year, accounting for 1% of cancers diagnosed.
Although there are many risk factors associated with the onset of the disease, some researchers suggested patients with chronic gastroesophageal reflux disease (GERD) are found to have a strong implication on the disease onset.
Dr. Shaheen N, the lead scientist at the University of North Carolina-Chapel Hil, wrote, "Gastroesophageal reflux disease (GERD) is a risk factor for adenocarcinoma of the esophagus, rare cancer whose incidence is increasing".
However, "Strong evidence supports the association of GERD and adenocarcinoma of the esophagus; however, the risk of cancer in any given individual with GERD is low".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to discover a potential ingredient for the treatment of esophageal cancer, researchers investigated the possible cytotoxic effect of freeze-dried aqueous extract of E. elaterium fruit on KYSE30 (human esophageal squamous cell carcinoma).
The study included the free dried aqueous extract of the fruits of E. elaterium incubated for 24, 48, and 72 h. on KYSE30 cancer cell lines.
The extracts showed a significant effect in the inhibition of the KYSE30 cell line at IC(50) values at concentrations of 500, 150, and 125 μg/ml after 24, 48, and 72 h, respectively.
According to the EB/AO staining, the extract showed an increase in apoptotic cells of the KYSE30 cell line.
Furthermore, the free-dried aqueous extract of the fruits of E. elaterium exerted a significant increase in cell density at the G2/M phase before inducing cell cycle arrest, according to the cell cycle analysis.
Based on the findings, researchers suggested that the freeze-dried aqueous extract of E. elaterium fruit has a cytotoxic effect on esophageal cancer cell lines via the induction of apoptosis.
Dr. Bohlooli S, the lead scientist wrote, " It seems that several compounds are possibly responsible for the cytotoxic effect of the extract".
In other words, several compounds in the extract worked synergistically to exhibit cytotoxicity against the tested cancer cell line.
Taken altogether, cucumber may be considered supplements for the prevention and treatment of esophageal cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastricadenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines by Bohlooli S1, Jafari N, Jahed S. (PubMed)
(2) Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review by Shaheen N1, Ransohoff DF. (PubMed)
#Ginger Regulates the Pathways and Suppresses Adipose Expansion and Inflammation Against #Obesity
Kyle J. Norton
Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.
Obesity is a medical disease associated with extreme overweight.
In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
What causes obesity? Some researchers suggested that too much calorie consumption and lack of physical exercise are the 2 main causes of obesity in once-healthy individuals.
Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of Americans and the promotion of the Western diet in the past few decades.
Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".
And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet or even a lack of essential vitamins and minerals".
These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.
Application of ginger in vivo and in vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,
Diet-induced obesity was attenuated in C57BL/6J mice treated with the dietary ginger extract (GE)also exhibited an increase in energy expenditure.
GE also exerted an anti-obesity effect by promoting the increased number of Types I muscle fibers, running endurance capacity, and upregulated PPARδ-targeted gene expression in skeletal muscle
Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.
After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".
Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers showed that ginger enone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).
In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.
Dr.Suk S the lead author said in the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".
Taken altogether, ginger processed with abundant bioactive compounds may be considered a functional food in stimulating weight loss in obese subjects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on the human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in terms of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.
Obesity is a medical disease associated with extreme overweight.
In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
What causes obesity? Some researchers suggested that too much calorie consumption and lack of physical exercise are the 2 main causes of obesity in once-healthy individuals.
Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of Americans and the promotion of the Western diet in the past few decades.
Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".
And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet or even a lack of essential vitamins and minerals".
These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.
Application of ginger in vivo and in vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,
Diet-induced obesity was attenuated in C57BL/6J mice treated with the dietary ginger extract (GE)also exhibited an increase in energy expenditure.
GE also exerted an anti-obesity effect by promoting the increased number of Types I muscle fibers, running endurance capacity, and upregulated PPARδ-targeted gene expression in skeletal muscle
Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.
After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".
Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers showed that ginger enone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).
In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.
Dr.Suk S the lead author said in the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".
Taken altogether, ginger processed with abundant bioactive compounds may be considered a functional food in stimulating weight loss in obese subjects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on the human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in terms of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
#Eggplant #Extract (SME) Modulates the Blood Pressure Associated with the Risk of #HeartDiseases, According to Studies
Kyle J. Norton
Eggplant may have a potential and substantial effect in reduced risk and treatment of high blood pressure, some scientists suggested.
Eggplant is a species of S. melongena with deep purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Hypertension is a long term medical condition characterized by abnormally high blood pressure.
According to statistics from the World Health Organization, high blood pressure affects 1.13 billion people worldwide and from 1975 to 2015, mean systolic blood pressure and blood pressure have stayed more or less the same in men and have decreased slightly among women.
According to the University of Massachusetts, eggplant containing high fiber and low soluble carbohydrate content and the phenolic-linked antioxidant activity and alpha-glucosidase exerted powerful antioxidant effects in inhibited free radical expression and ROS chain reaction to induce type 2 diabetes' complications such as hypertension.
Further analysis also suggested that functional food also inhibited the angiotensin hormone which has been found to elevate vasoconstriction and increase blood pressure in diabetics.
Dr. Kwon YI, after taking into account of other confounders, suggested. " high angiotensin I-converting enzyme (ACE) inhibitory activity (Of eggplant),....... provide a strong biochemical basis for ....... reducing associated hypertension".
Indeed, the recommendation to include a portion of eggplant in daily diet by the National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association may be a choice to reduce diabetes complication risk of hypertension.
The illustration strongly indicated that oxidative stress initiated by ROS may place an important role in the risk of diabetes and diabetes hypertension.
Interestingly, in the study to evaluate the cardiovascular action of Solanum melongena extract (SME) in vivo and in vitro, researchers found that the application of SME displays a significant and produced dose-dependent effect in reduced hypertensive responses in normotensive albino rats through the modulated expression of β-adrenoceptor on cardiac and smooth muscle tissues in precipitated high blood pressure.
Additionally, the administration of SME regulated the stimulation of the expression of the muscarinic receptors in reduced high blood pressure as well as improving heart rate.
Furthermore, SME injection also decreased the efficacy of the medication of β-adrenoceptor blocker, propranolol, and the cholinergic receptor blocker, atropine in regulating abnormal heart rhythms, and to protect the heart from a second heart attack (myocardial infarction) after a first heart attack (secondary prevention).
In other words, increasing doses of β-adrenoceptor blocker, propranolol, and the cholinergic receptor blocker may be necessary to achieve the same effect in reducing the risk of heart attack with the intake of eggplant.
More precisely, researchers suggested that SME modulated high blood pressure through induction of vaso-relaxation and negative inotropy and mediation of the β-adrenergic and acetylcholine receptors in promoted vasodilation of the resistant vessels and a reduction in heart activity, respectively.
Conclusively, in comparison to Captopril, a hypertensive medicine, researchers also indicated that possibly, the hypotensive effect of SME could be attributed to SME influence on the activity of the renin-angiotensin system, which is a hormone system with function in regulated blood pressure and fluid balance.
In fact, the effect of eggplant in the regulated function of diuresis in the renin-angiotensin system may result in an ameliorated risk of high blood pressure as diuretics were found to associate to the function of kidneys in removal of more sodium and water from the body, triggering relaxation of the blood vessel walls, thereby lowering blood pressure.
Taken together, eggplant and its phytochemicals may be considered a functional food processed a therapeutic and potential effect in reducing the risk of hypertension naturally.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) Hypotensive action of Solanum melongena on normotensive rats by O. L. Shum and K. W. Chiu(Wiley Online Library)
Eggplant may have a potential and substantial effect in reduced risk and treatment of high blood pressure, some scientists suggested.
Eggplant is a species of S. melongena with deep purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Hypertension is a long term medical condition characterized by abnormally high blood pressure.
According to statistics from the World Health Organization, high blood pressure affects 1.13 billion people worldwide and from 1975 to 2015, mean systolic blood pressure and blood pressure have stayed more or less the same in men and have decreased slightly among women.
According to the University of Massachusetts, eggplant containing high fiber and low soluble carbohydrate content and the phenolic-linked antioxidant activity and alpha-glucosidase exerted powerful antioxidant effects in inhibited free radical expression and ROS chain reaction to induce type 2 diabetes' complications such as hypertension.
Further analysis also suggested that functional food also inhibited the angiotensin hormone which has been found to elevate vasoconstriction and increase blood pressure in diabetics.
Dr. Kwon YI, after taking into account of other confounders, suggested. " high angiotensin I-converting enzyme (ACE) inhibitory activity (Of eggplant),....... provide a strong biochemical basis for ....... reducing associated hypertension".
Indeed, the recommendation to include a portion of eggplant in daily diet by the National Diabetes Education Program of NIH, Mayo Clinic and American Diabetes Association may be a choice to reduce diabetes complication risk of hypertension.
The illustration strongly indicated that oxidative stress initiated by ROS may place an important role in the risk of diabetes and diabetes hypertension.
Interestingly, in the study to evaluate the cardiovascular action of Solanum melongena extract (SME) in vivo and in vitro, researchers found that the application of SME displays a significant and produced dose-dependent effect in reduced hypertensive responses in normotensive albino rats through the modulated expression of β-adrenoceptor on cardiac and smooth muscle tissues in precipitated high blood pressure.
Additionally, the administration of SME regulated the stimulation of the expression of the muscarinic receptors in reduced high blood pressure as well as improving heart rate.
Furthermore, SME injection also decreased the efficacy of the medication of β-adrenoceptor blocker, propranolol, and the cholinergic receptor blocker, atropine in regulating abnormal heart rhythms, and to protect the heart from a second heart attack (myocardial infarction) after a first heart attack (secondary prevention).
In other words, increasing doses of β-adrenoceptor blocker, propranolol, and the cholinergic receptor blocker may be necessary to achieve the same effect in reducing the risk of heart attack with the intake of eggplant.
More precisely, researchers suggested that SME modulated high blood pressure through induction of vaso-relaxation and negative inotropy and mediation of the β-adrenergic and acetylcholine receptors in promoted vasodilation of the resistant vessels and a reduction in heart activity, respectively.
Conclusively, in comparison to Captopril, a hypertensive medicine, researchers also indicated that possibly, the hypotensive effect of SME could be attributed to SME influence on the activity of the renin-angiotensin system, which is a hormone system with function in regulated blood pressure and fluid balance.
In fact, the effect of eggplant in the regulated function of diuresis in the renin-angiotensin system may result in an ameliorated risk of high blood pressure as diuretics were found to associate to the function of kidneys in removal of more sodium and water from the body, triggering relaxation of the blood vessel walls, thereby lowering blood pressure.
Taken together, eggplant and its phytochemicals may be considered a functional food processed a therapeutic and potential effect in reducing the risk of hypertension naturally.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) Hypotensive action of Solanum melongena on normotensive rats by O. L. Shum and K. W. Chiu(Wiley Online Library)
#Healthyfood Cruciferous Vegetables Intakes are Linearly Associated with the Risk of #Atherosclerosis, Researchers Say
Kyle J. Norton
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels.
The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaque build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain.
Atherosclerosis is a medical condition caused by plaques accumulating on the wall of the arteries, leading to the narrowing of the arteries in transporting oxygenated blood to the heart and other parts of the body.
Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage to the inner lining of the artery. However, the actual causes of the condition are debatable.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis, including 13.8% among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease, and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part of plaque, an unhealthy diet with high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for the prevention of plaque accumulated on the arterial wall, researchers the effect of vegetable intake alone, and its relationships to specific types of vegetables containing different phytochemical profiles on atherosclerosis.
According to the food questionnaire returned by the participants, using the total vegetable intake calculated at baseline (1998),
* Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean common carotid artery IMT (CCA-IMT, P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming <2 servings of vegetables.
* Furthermore, for each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA-IMT (P<0.01) and 0.007 mm (0.8%) lower maximum CCA-IMT (P<0.01).
* Some vegetable types showed no association with CCA-IMT (P>0.05).
* Interestingly, there were no associations observed between vegetables and plaque severity (P>0.05).
Based on the results, researchers said, "Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women".
Taken together, cruciferous vegetables may be considered functional remedies for the prevention of atherosclerosis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women by Blekkenhorst LC1,2,3, Bondonno CP4,2, Lewis JR4,3,5,6, Woodman RJ7, Devine A4, Bondonno NP2, Lim WH8, Zhu K9, Beilin LJ2, Thompson PL10, Prince RL3,9, Hodgson JM. (PubMed)
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels.
The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaque build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain.
Atherosclerosis is a medical condition caused by plaques accumulating on the wall of the arteries, leading to the narrowing of the arteries in transporting oxygenated blood to the heart and other parts of the body.
Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage to the inner lining of the artery. However, the actual causes of the condition are debatable.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis, including 13.8% among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease, and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part of plaque, an unhealthy diet with high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for the prevention of plaque accumulated on the arterial wall, researchers the effect of vegetable intake alone, and its relationships to specific types of vegetables containing different phytochemical profiles on atherosclerosis.
According to the food questionnaire returned by the participants, using the total vegetable intake calculated at baseline (1998),
* Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean common carotid artery IMT (CCA-IMT, P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming <2 servings of vegetables.
* Furthermore, for each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA-IMT (P<0.01) and 0.007 mm (0.8%) lower maximum CCA-IMT (P<0.01).
* Some vegetable types showed no association with CCA-IMT (P>0.05).
* Interestingly, there were no associations observed between vegetables and plaque severity (P>0.05).
Based on the results, researchers said, "Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women".
Taken together, cruciferous vegetables may be considered functional remedies for the prevention of atherosclerosis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women by Blekkenhorst LC1,2,3, Bondonno CP4,2, Lewis JR4,3,5,6, Woodman RJ7, Devine A4, Bondonno NP2, Lim WH8, Zhu K9, Beilin LJ2, Thompson PL10, Prince RL3,9, Hodgson JM. (PubMed)
#Carrots Inhibit Parameters Associated with the Onset of Neuro-degenerative Disorders, Scientists Reveal
Kyle J. Norton
Carrots may have a profound and positive effect in reducing risk, progression, and treatment of neurodegenerative disorder, some scientists suggested.
Neurodegeneration is the progressive loss of neurons including the death of neurons, characterized by structure loss-induced reduction of brain function.
The exact causes of neurodegenerative disorders are unknown. Researchers also do not why people with the same health conditions, are susceptible to certain neurodegenerative disorders such as
Huntington's disease. ALS (amyotrophic lateral sclerosis), or Lou Gehrig's disease, Parkinson's disease, or other forms of dementia, while others do not.
However, some researchers suggested that genetic mutation inherited from parents, certain illnesses and traumatic injury to the brain are some of the major causes of the onset of the disease.
According to Dr. Chaudhuri K, in the study of unhealthy diet and lifestyle on risk of neurodegenerative disorders, the onset of some neurodegenerative disorders was attributed to the unwholesome diet that disturbed mental health in initiating etiopathogenesis of senile dementia.
Further differentiation showed that psychological syndromes such as disturbed sleep, anxiety, tension, depression, difficulty in concentration, and memory, and the tendency to indulge in defective dietary habits, Kapha vitiating diets, and lifestyle are some predominant risk factors associated with the development of the disease.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
In the evaluation, the neurodegenerative disorder such as Alzheimer's and Parkinson's diseases affecting the central nervous system with debilitating effects on the patient, researchers at the University Technology of Mauritius launched a study to test the efficacy of flavonoids, found in many vegetables including carrots.
Flavonoids are phytochemicals containing a number of the member, including curcumin, lycopene, ginsenoside, vitexin, and baicalin with a proven record of anti-cancer and antioxidant and immunomodulation properties in a number of studies.
At the results of the analysis, researchers showed that the application of flavonoid to the brain ischemia patient also exerts potential neuroprotective effects by increasing neuronal viability, tissue perfusion, and cerebral blood flow and reducing ischemic-related apoptosis.
Moreover, patients treated with flavonoids also demonstrated a significantly anti-amyloidogenic effect and reduced the loss of dopaminergic neurons in the brain which has a strong implication in patients with Pakistan's disease.
After taking into account other co and confounders, researchers concluded that flavonoids found in a number of vegetables and fruits, including carrots, may be served as a potential therapeutic agent in brain disorders.
Further differentiation of the oxidative stress which causes neurodegenerative disorder, including oxidative damage to neurons in the induction of mitochondrial dysfunction and apoptosis, scientists at the Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region conducted an experiment to test the effect of lycopene, a polyunsaturated hydrocarbon with the highest antioxidant capacity compared to the other carotenoids against the expression of the diseases.
In rat model was randomly divided into 5 groups: the sham group, the spinal cord injury (SCI) group, and 3 SCI groups pre-treated with lycopene (5, 10, or 20mg/kg) researchers found that
* Spinal cord injury (SCI) group without treatment group displays a significant increase of malondialdehyde (MDA) content and a decrease of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels, compared to other groups.
Malondialdehyde (MDA) the final form of polyunsaturated fatty acids peroxidation is considered as a natural marker for oxidative stress.
* Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) are natural antioxidants that are produced in the host body tissue with an aim to maintain the balance of the ratio of reactive oxygen species and antioxidants in the body.
The expression of lower levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) is a strong indication of overabundant free radicals, compared to levels of antioxidants in the body.
* Group treated with lycopene regardless to concentration exerted an overwhelming effect in blocking the change of mRNA of the mitochondrial membrane caused by spinal cord injury (SCI), including cytochrome b and mitochondrial transcription factor A (Tfam), with functions in the induction of mitochondrial dysfunction.
Cytochrome b, a protein in the mitochondria of eukaryotic cells functioned as a part of the electron transport chain which was oxidated in this case.
Mitochondrial transcription factor A (mtTFA or Tfam), is a protein with functions as a key regulator of mammalian mitochondrial (mt) DNA transcription and replication which was altered caused by the presence of MDA.
Further analysis also found that the application of lycopene also reduces the risk of neuron cell apoptosis through decreased levels of pro-inflammatory and increased levels of anti-inflammatory expression in the tested rats.
These results suggested that lycopene found in vegetables including carrots significantly ameliorated oxidative damage, mitochondrial dysfunction, and cell apoptosis via some parameters indicated above.
Dr. Hu W, the lead author said in the classification of doses application said, " lycopene significantly ameliorated the hind limb motor disturbances in the SCI+lyco10 group and the SCI+lyco20 group compared with the SCI group".
Taken together, carrots with a high amount of bioactive flavonoids, particularly lycopene may be considered a functional food in reducing the risk and treatment of various forms of the neurodegenerative disorder, including Alzheimer's and Parkinson's diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway by Hu W1, Wang H2, Liu Z2, Liu Y2, Wang R2, Luo X2, Huang Y3(PubMed)
(2) Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases by Putteeraj M1, Lim WL2, Teoh SL3, Yahaya MF(PubMed)
(3) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PuibMed)
Carrots may have a profound and positive effect in reducing risk, progression, and treatment of neurodegenerative disorder, some scientists suggested.
Neurodegeneration is the progressive loss of neurons including the death of neurons, characterized by structure loss-induced reduction of brain function.
The exact causes of neurodegenerative disorders are unknown. Researchers also do not why people with the same health conditions, are susceptible to certain neurodegenerative disorders such as
Huntington's disease. ALS (amyotrophic lateral sclerosis), or Lou Gehrig's disease, Parkinson's disease, or other forms of dementia, while others do not.
However, some researchers suggested that genetic mutation inherited from parents, certain illnesses and traumatic injury to the brain are some of the major causes of the onset of the disease.
According to Dr. Chaudhuri K, in the study of unhealthy diet and lifestyle on risk of neurodegenerative disorders, the onset of some neurodegenerative disorders was attributed to the unwholesome diet that disturbed mental health in initiating etiopathogenesis of senile dementia.
Further differentiation showed that psychological syndromes such as disturbed sleep, anxiety, tension, depression, difficulty in concentration, and memory, and the tendency to indulge in defective dietary habits, Kapha vitiating diets, and lifestyle are some predominant risk factors associated with the development of the disease.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
In the evaluation, the neurodegenerative disorder such as Alzheimer's and Parkinson's diseases affecting the central nervous system with debilitating effects on the patient, researchers at the University Technology of Mauritius launched a study to test the efficacy of flavonoids, found in many vegetables including carrots.
Flavonoids are phytochemicals containing a number of the member, including curcumin, lycopene, ginsenoside, vitexin, and baicalin with a proven record of anti-cancer and antioxidant and immunomodulation properties in a number of studies.
At the results of the analysis, researchers showed that the application of flavonoid to the brain ischemia patient also exerts potential neuroprotective effects by increasing neuronal viability, tissue perfusion, and cerebral blood flow and reducing ischemic-related apoptosis.
Moreover, patients treated with flavonoids also demonstrated a significantly anti-amyloidogenic effect and reduced the loss of dopaminergic neurons in the brain which has a strong implication in patients with Pakistan's disease.
After taking into account other co and confounders, researchers concluded that flavonoids found in a number of vegetables and fruits, including carrots, may be served as a potential therapeutic agent in brain disorders.
Further differentiation of the oxidative stress which causes neurodegenerative disorder, including oxidative damage to neurons in the induction of mitochondrial dysfunction and apoptosis, scientists at the Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region conducted an experiment to test the effect of lycopene, a polyunsaturated hydrocarbon with the highest antioxidant capacity compared to the other carotenoids against the expression of the diseases.
In rat model was randomly divided into 5 groups: the sham group, the spinal cord injury (SCI) group, and 3 SCI groups pre-treated with lycopene (5, 10, or 20mg/kg) researchers found that
* Spinal cord injury (SCI) group without treatment group displays a significant increase of malondialdehyde (MDA) content and a decrease of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels, compared to other groups.
Malondialdehyde (MDA) the final form of polyunsaturated fatty acids peroxidation is considered as a natural marker for oxidative stress.
* Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) are natural antioxidants that are produced in the host body tissue with an aim to maintain the balance of the ratio of reactive oxygen species and antioxidants in the body.
The expression of lower levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) is a strong indication of overabundant free radicals, compared to levels of antioxidants in the body.
* Group treated with lycopene regardless to concentration exerted an overwhelming effect in blocking the change of mRNA of the mitochondrial membrane caused by spinal cord injury (SCI), including cytochrome b and mitochondrial transcription factor A (Tfam), with functions in the induction of mitochondrial dysfunction.
Cytochrome b, a protein in the mitochondria of eukaryotic cells functioned as a part of the electron transport chain which was oxidated in this case.
Mitochondrial transcription factor A (mtTFA or Tfam), is a protein with functions as a key regulator of mammalian mitochondrial (mt) DNA transcription and replication which was altered caused by the presence of MDA.
Further analysis also found that the application of lycopene also reduces the risk of neuron cell apoptosis through decreased levels of pro-inflammatory and increased levels of anti-inflammatory expression in the tested rats.
These results suggested that lycopene found in vegetables including carrots significantly ameliorated oxidative damage, mitochondrial dysfunction, and cell apoptosis via some parameters indicated above.
Dr. Hu W, the lead author said in the classification of doses application said, " lycopene significantly ameliorated the hind limb motor disturbances in the SCI+lyco10 group and the SCI+lyco20 group compared with the SCI group".
Taken together, carrots with a high amount of bioactive flavonoids, particularly lycopene may be considered a functional food in reducing the risk and treatment of various forms of the neurodegenerative disorder, including Alzheimer's and Parkinson's diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway by Hu W1, Wang H2, Liu Z2, Liu Y2, Wang R2, Luo X2, Huang Y3(PubMed)
(2) Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases by Putteeraj M1, Lim WL2, Teoh SL3, Yahaya MF(PubMed)
(3) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PuibMed)
#Healthyfood Tomatoes inhibit the Onset of NAFLD and #LiverCancer in Vivo
Kyle J. Norton
Liver cancer is a chronic condition characterized by irregular cell growth in the liver tissues due to the alternation of cell DNA.
Most cases of primary liver cancer begin in the cells on the surface of the inner lining tissues of the liver.
Patients in the early stage of liver cancer, due to the small size of the tumor, are asymptomatic. However, at the advanced, after colonizing the deeper layers of the liver, the malignant cells may travel a distance away to infect other nearby tissues, leading to secondary metastasis.
The liver is the largest internal organ with a function that filters out blood coming from the digestive tract before passing them to other parts of the body.
Furthermore, the liver also produces cholesterol that not only aids the gastrointestinal tract in digesting food and absorbing nutrients but also helps to build a strong cell wall, and produce vitamin D and steroid hormones.
Also, at the advanced stage, patients with liver cancer may experience upper abdominal pain, abdominal swelling jaundice, and white, chalky stools accompanied by the general symptoms shared by other types of cancer.
According to the statistics provided by the American Cancer Society, in 2019, approximately 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed in the US.
Liver cancer will also cause the death of about 31,780 Americans (21,600 men and 10,180 women) in 2019.
Although there are many risk factors associated with the onset of liver cancer, some researchers suggested that the rise of obesity-induced non-alcoholic liver disease may be a leading cause of liver cancer among Americans.
Dr. György Baffy wrote, "NAFLD is rapidly becoming the most common liver condition, it has been implicated in the worrisome trend of rising HCC incidence in a number of countries, which may offset successful measures in reducing the effect of virus-related liver cancer".
And, "Independently or in synergy with cirrhosis, NAFLD may provide a special oncogenic microenvironment through its pathogenic association with chronic nutrient excess and adipose tissue remodeling, characterized by pro-inflammatory adipokine profiles, lipotoxicity, altered hepatocellular bioenergetics, and insulin resistance".
In other words, if you are obese with NAFLD, you are at an increased risk of liver cancer.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of liver cancer, researchers examined the effect of lycopene from tomatoes against NAFLD and hepatocellular carcinoma (HCC).
The study included tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lesions in both lungs and livers of ferrets with or without lycopene intervention.
More precisely, selected male ferrets (6 groups, n = 8-10) were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, the NNK group showed a higher incidence of lung tumors, HCC, and steatohepatitis and elevations in bilirubin and AST levels.
Administration of lycopene supplementation at two doses not only prevented NNK-induced expressions of α7 nicotinic acetylcholine receptor in the lung associated with liver injury and cells damage but also reduced the expression of a protein associated pro-inflammation, particularly, in the level of CYP2E1 involved in the metabolism of xenobiotics in the body in the liver
Furthermore, lycopene also attenuated the NNK-induced mortality and pathological lesions in the liver of ferrets.
Based on the results, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Moreover, in the examined the natural whole foods which process anti-liver cancer potential, Dr. Zhou Y, the lead scientist wrote, "..., tomatoes,... These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs".
Taken together, tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Natural Products for Prevention and Treatment of Liver Cancer by Zhou Y1, Li Y2, Zhou T3, Zheng J4, Li S5, Li HB. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention by György Baffy. (PMC)
Liver cancer is a chronic condition characterized by irregular cell growth in the liver tissues due to the alternation of cell DNA.
Most cases of primary liver cancer begin in the cells on the surface of the inner lining tissues of the liver.
Patients in the early stage of liver cancer, due to the small size of the tumor, are asymptomatic. However, at the advanced, after colonizing the deeper layers of the liver, the malignant cells may travel a distance away to infect other nearby tissues, leading to secondary metastasis.
The liver is the largest internal organ with a function that filters out blood coming from the digestive tract before passing them to other parts of the body.
Furthermore, the liver also produces cholesterol that not only aids the gastrointestinal tract in digesting food and absorbing nutrients but also helps to build a strong cell wall, and produce vitamin D and steroid hormones.
Also, at the advanced stage, patients with liver cancer may experience upper abdominal pain, abdominal swelling jaundice, and white, chalky stools accompanied by the general symptoms shared by other types of cancer.
According to the statistics provided by the American Cancer Society, in 2019, approximately 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed in the US.
Liver cancer will also cause the death of about 31,780 Americans (21,600 men and 10,180 women) in 2019.
Although there are many risk factors associated with the onset of liver cancer, some researchers suggested that the rise of obesity-induced non-alcoholic liver disease may be a leading cause of liver cancer among Americans.
Dr. György Baffy wrote, "NAFLD is rapidly becoming the most common liver condition, it has been implicated in the worrisome trend of rising HCC incidence in a number of countries, which may offset successful measures in reducing the effect of virus-related liver cancer".
And, "Independently or in synergy with cirrhosis, NAFLD may provide a special oncogenic microenvironment through its pathogenic association with chronic nutrient excess and adipose tissue remodeling, characterized by pro-inflammatory adipokine profiles, lipotoxicity, altered hepatocellular bioenergetics, and insulin resistance".
In other words, if you are obese with NAFLD, you are at an increased risk of liver cancer.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of liver cancer, researchers examined the effect of lycopene from tomatoes against NAFLD and hepatocellular carcinoma (HCC).
The study included tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lesions in both lungs and livers of ferrets with or without lycopene intervention.
More precisely, selected male ferrets (6 groups, n = 8-10) were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, the NNK group showed a higher incidence of lung tumors, HCC, and steatohepatitis and elevations in bilirubin and AST levels.
Administration of lycopene supplementation at two doses not only prevented NNK-induced expressions of α7 nicotinic acetylcholine receptor in the lung associated with liver injury and cells damage but also reduced the expression of a protein associated pro-inflammation, particularly, in the level of CYP2E1 involved in the metabolism of xenobiotics in the body in the liver
Furthermore, lycopene also attenuated the NNK-induced mortality and pathological lesions in the liver of ferrets.
Based on the results, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Moreover, in the examined the natural whole foods which process anti-liver cancer potential, Dr. Zhou Y, the lead scientist wrote, "..., tomatoes,... These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs".
Taken together, tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Natural Products for Prevention and Treatment of Liver Cancer by Zhou Y1, Li Y2, Zhou T3, Zheng J4, Li S5, Li HB. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention by György Baffy. (PMC)
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