Kyle J. Norton
Alcohol toxicity is a result of excessive consumption of alcohol that leads to alcohol poisoning.
People with a high level of blood alcohol may experience symptoms of confusion, unresponsiveness, and disorientation.
If severe cases, patients may lose conscientiousness or go into a coma.
Long-term excessive alcohol consumption may cause liver damage, leading to the symptoms of jaundice, cirrhosis, liver failure, and liver cancer.
Some people may experience symptoms of alcohol withdrawal symptoms after a day of heavy drinking day. Depending on the body's response, some people may experience alcohol withdrawal symptoms as early as two hours after the last drink.
However, most people may experience the symptoms as soon as they wake up after a night of sleep. The symptoms will peak within the first 24 to 48 hours.
The most common alcohol withdrawal symptoms are a rapid heartbeat changes in blood pressure, sweating, tremors, and fever.
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural compound that processes anti-alcoholic toxicity, researchers investigated the heat-treated cucumber juice's protective effect on blood alcohol levels and hepatic alcohol metabolic enzyme system in experimental rats.
The study included alcoholic toxicity rats orally dosed with 22% alcohol (6ml/kg body weight) along with different concentrations of heat-treated cucumber juice (10, 100, and 500mg/kg) and commercial goods for hangover-removal on sale (2ml/kg).
According to the tested results, after 7h, all concentrations of heat-treated cucumber remarkably reduced the blood alcohol levels.
Furthermore, levels of dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) enzymatic activities associated with detoxicity in rat liver at 9h after alcohol administration were also increased in the treated rats.
The effect of heat-treated cucumber juice on alcohol detoxification was observed only in the rats treated before 30min from alcohol administration may be involved in stimulated blood alcohol metabolism.
Based on the finding, researchers said, "These findings indicate that heat-treated cucumber juice has a significant protective effect on alcohol detoxification in experimental rats, suggesting its usefulness in the treatment of the liver injury caused by alcohol consumption".
Taken altogether, heat-treated cucumber may be used for the prevention and treatment of alcoholic toxicity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of heat-treated cucumber (Cucumis sativus L.) juice on alcoholdetoxification in experimental rats by Bajpai VK1, Kim NH2, Kim JE3, Kim K4, Kang SC. (PubMed)
(2) NADPH-dependent reductases involved in the detoxification of reactive carbonyls in plants by Yamauchi Y1, Hasegawa A, Taninaka A, Mizutani M, Sugimoto Y. (PubMed)
Monday, 7 August 2023
#AlphaTocopherols Inhibit the Increased Renal mRNA Levels of Calnexin Against the Onset of #ChronicKidneyDisease (CKD) to End-Stage #RenalDisease
Kyle J. Norton
The kidneys are a pair of kidney-shaped organs located on either side of your spine with the function to filter out the wastes from the blood before passing the wastes through urinary secretion.
More than a detoxed organ, the kidneys also maintain the body fluid balance, regulate the production of red blood cells and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
At the advanced of CKD can cause the dangerous levels of fluid, electrolytes and wastes build up in the body.
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins to accumulate in the blood. In this stage, dialysis and kidney transplant are the only options.
According to statistics, approximately 14 percent of the US general population suffers from CKD. Believe it or not, more than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
In finding a potential phytochemical for the treatment of kidney diseases, researchers examined the pretreatment effect of alpha-tocopherol against oxidative renal tubular damage and subsequent carcinogenesis by ferric nitrilotriacetate (Fe-NTA) in rats.
According to the tested analysis, injection of Fe-NTA in rats fed a standard diet showed an increase of renal mRNA levels of calnexin significantly in 3 hours of treatment associated with the progression of chronic kidney disease (CKD) to end-stage renal disease.
After the injection of alpha-tocopherol, the levels of renal calnexin mRNA levels were decreased, without altering the protein levels.
In LLC-PK1 cells, the addition of alpha-tocopherol showed strong protective activity against oxidative stress induced by H2O2.
Furthermore, alpha-tocopherol-induced N-acetylglucosaminyltransferase 3 was involved in kidney cancer suppression in the tested mice.
Moreover, alpha-tocopherol modifies glycoprotein metabolism and partially induced cancer and inflammation by conferring mild ER stress in the protection against kidney cell damage.
Taken altogether, tocopherols may be considered a functional supplement for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage by Lee WH1, Akatsuka S, Shirase T, Dutta KK, Jiang L, Liu YT, Onuki J, Yamada Y, Okawa K, Wada Y, Watanabe A, Kohro T, Noguchi N, Toyokuni S. (PubMed)
The kidneys are a pair of kidney-shaped organs located on either side of your spine with the function to filter out the wastes from the blood before passing the wastes through urinary secretion.
More than a detoxed organ, the kidneys also maintain the body fluid balance, regulate the production of red blood cells and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
At the advanced of CKD can cause the dangerous levels of fluid, electrolytes and wastes build up in the body.
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins to accumulate in the blood. In this stage, dialysis and kidney transplant are the only options.
According to statistics, approximately 14 percent of the US general population suffers from CKD. Believe it or not, more than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
In finding a potential phytochemical for the treatment of kidney diseases, researchers examined the pretreatment effect of alpha-tocopherol against oxidative renal tubular damage and subsequent carcinogenesis by ferric nitrilotriacetate (Fe-NTA) in rats.
According to the tested analysis, injection of Fe-NTA in rats fed a standard diet showed an increase of renal mRNA levels of calnexin significantly in 3 hours of treatment associated with the progression of chronic kidney disease (CKD) to end-stage renal disease.
After the injection of alpha-tocopherol, the levels of renal calnexin mRNA levels were decreased, without altering the protein levels.
In LLC-PK1 cells, the addition of alpha-tocopherol showed strong protective activity against oxidative stress induced by H2O2.
Furthermore, alpha-tocopherol-induced N-acetylglucosaminyltransferase 3 was involved in kidney cancer suppression in the tested mice.
Moreover, alpha-tocopherol modifies glycoprotein metabolism and partially induced cancer and inflammation by conferring mild ER stress in the protection against kidney cell damage.
Taken altogether, tocopherols may be considered a functional supplement for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage by Lee WH1, Akatsuka S, Shirase T, Dutta KK, Jiang L, Liu YT, Onuki J, Yamada Y, Okawa K, Wada Y, Watanabe A, Kohro T, Noguchi N, Toyokuni S. (PubMed)
#Potato Protein Hydrolysate #APPH Inhibits the Elevated Levels of Fibrosis Markers Associated with Liver Damage Induced Fibrosis, Researchers Say
Kyle J. Norton
Fibrosis is a condition characterized by overly exuberant wound healing causing excessive connective tissue builds up in the organ tissues In other words, hepatic fibrosis is a portion of the liver which was affected by scar formation.
The exact causes of fibrosis are unknown. However, certain risk factors such as repeated liver injury caused by a virus infection, and a blockage in the bile ducts are found to elaborate on the onset of fibrosis.
The 2 most common types of fibrosis in the human body are
* Renal fibrosis is a progressive condition caused by excessive accumulation of extracellular matrix including collagen, enzymes, and glycoproteins which provided structural and biochemical support surrounding the renal cells during aging and chronic kidney disease (CKD).
According to the statistics, CKD and renal fibrosis affect approximately half of the adults aged 70 and over and 10% of the world's population.
In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.
Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.
* Liver fibrosis is a chronic liver disease due to liver scars overwhelmingly building up in the connective tissue in the liver.
A severe case of hepatic fibrosis can lead to cirrhosis, affecting the liver function in filtering the blood. In the US, over 4.5 million people are affected by liver cirrhosis, leading to the death of 12/100,000 of the population every year.
The most common causes of liver fibrosis are excessive alcohol drinking and infection by the hepatitis virus.
Long-term untreated liver fibrosis can lead to cirrhosis, a condition of severe scarring of the liver and life-threatening liver disease.
Potato is the genus Solanum, belongs to the family Solanaceae. the root veggie is a good source of protein.
According to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potatoes. Potato now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.
In finding a potential plant that processes anti-fibrotic activity researchers examined the effect of APPH, a potato protein hydrolysate on a high-fat diet (HFD) associated liver damage.
The study included six-week-old male hamsters that were randomly separated into six groups (n = 8) as control, HFD (HFD fed obese), L-APPH (HFD + 15 mg/kg/day of APPH), M-APPH (HFD + 30 mg/kg/day), H-APPH (HFD + 75 mg/kg/day of APPH) and PB (HFD + 500 mg/kg/day of probucol) with HFD fed hamsters were administered with APPH 50 days through oral gavage.
According to the results of the analysis,* Hamsters fed with a high-fat diet showed symptoms of liver damage as measured from serum stress markers like alanine aminotransferase and aspartate aminotransferase levels.
* Furthermore, HFD also modulated the expression of survival and apoptosis proteins in the hamster liver.
* Moreover, the HFD groups showed elevated levels of fibrosis markers in the liver correlated with the increase in the levels of phosphorylated extracellular signal-regulated kinases (pERK1/2) induced liver cell differentiation in the HFD-mediated liver damage.
* The administration of a 50-day-long supplementation of APPH effectively ameliorated the effects of HFD.
* APPH treatment reduced the effect of HFD on the apoptosis and fibrosis markers considerably and provided hepato-protection.
Collectively, researchers said, "APPH can, therefore, be considered as an efficient therapeutic agent to ameliorate high-fat diet-related liver damages".
Taken together, potatoes may be considered a functional food for the prevention and treatment of liver fibrosis and damage induced fibrosis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protein hydrolysate from potato confers hepatic-protection in hamsters against high-fat diet-induced apoptosis and fibrosis by suppressing Caspase-3 and MMP2/9 and by enhancing Akt-survival pathway by Asokan SM1,2, Hung TH3, Li ZY3, Chiang WD4, Lin WT. (PubMed)
Fibrosis is a condition characterized by overly exuberant wound healing causing excessive connective tissue builds up in the organ tissues In other words, hepatic fibrosis is a portion of the liver which was affected by scar formation.
The exact causes of fibrosis are unknown. However, certain risk factors such as repeated liver injury caused by a virus infection, and a blockage in the bile ducts are found to elaborate on the onset of fibrosis.
The 2 most common types of fibrosis in the human body are
* Renal fibrosis is a progressive condition caused by excessive accumulation of extracellular matrix including collagen, enzymes, and glycoproteins which provided structural and biochemical support surrounding the renal cells during aging and chronic kidney disease (CKD).
According to the statistics, CKD and renal fibrosis affect approximately half of the adults aged 70 and over and 10% of the world's population.
In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.
Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.
* Liver fibrosis is a chronic liver disease due to liver scars overwhelmingly building up in the connective tissue in the liver.
A severe case of hepatic fibrosis can lead to cirrhosis, affecting the liver function in filtering the blood. In the US, over 4.5 million people are affected by liver cirrhosis, leading to the death of 12/100,000 of the population every year.
The most common causes of liver fibrosis are excessive alcohol drinking and infection by the hepatitis virus.
Long-term untreated liver fibrosis can lead to cirrhosis, a condition of severe scarring of the liver and life-threatening liver disease.
Potato is the genus Solanum, belongs to the family Solanaceae. the root veggie is a good source of protein.
According to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potatoes. Potato now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.
In finding a potential plant that processes anti-fibrotic activity researchers examined the effect of APPH, a potato protein hydrolysate on a high-fat diet (HFD) associated liver damage.
The study included six-week-old male hamsters that were randomly separated into six groups (n = 8) as control, HFD (HFD fed obese), L-APPH (HFD + 15 mg/kg/day of APPH), M-APPH (HFD + 30 mg/kg/day), H-APPH (HFD + 75 mg/kg/day of APPH) and PB (HFD + 500 mg/kg/day of probucol) with HFD fed hamsters were administered with APPH 50 days through oral gavage.
According to the results of the analysis,* Hamsters fed with a high-fat diet showed symptoms of liver damage as measured from serum stress markers like alanine aminotransferase and aspartate aminotransferase levels.
* Furthermore, HFD also modulated the expression of survival and apoptosis proteins in the hamster liver.
* Moreover, the HFD groups showed elevated levels of fibrosis markers in the liver correlated with the increase in the levels of phosphorylated extracellular signal-regulated kinases (pERK1/2) induced liver cell differentiation in the HFD-mediated liver damage.
* The administration of a 50-day-long supplementation of APPH effectively ameliorated the effects of HFD.
* APPH treatment reduced the effect of HFD on the apoptosis and fibrosis markers considerably and provided hepato-protection.
Collectively, researchers said, "APPH can, therefore, be considered as an efficient therapeutic agent to ameliorate high-fat diet-related liver damages".
Taken together, potatoes may be considered a functional food for the prevention and treatment of liver fibrosis and damage induced fibrosis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protein hydrolysate from potato confers hepatic-protection in hamsters against high-fat diet-induced apoptosis and fibrosis by suppressing Caspase-3 and MMP2/9 and by enhancing Akt-survival pathway by Asokan SM1,2, Hung TH3, Li ZY3, Chiang WD4, Lin WT. (PubMed)
Sunday, 6 August 2023
#Herbal #Ashwagandha's #Withaferin A (WA) Gobbles Up Human Head and Neck Cancer Cells Involving Caspase-Dependent Apoptosis In Vitro
Kyle J. Norton
Cancer is a group of diseases associated with cell growth disorderly and uncontrollably in the tissue of a specific organ. Over time cancer can become progressively worse and damage other healthy tissues.
Most cases of cancer start in the cells on the surface in the inner lining tissue of a specific organ, before traveling a distance away to affect other nearby tissue and organ.
Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.
Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. Patients with head and neck cancer at the very early stage are asymptomatic due to the very small size of the tumor.
However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.
The exact causes of head and neck cancer are not identified. However, researchers found that excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust are prevalent factors associated with an increased risk of head and neck cancer.
Dr. Kazuhiro Kobayashi in the investigation of the risk of HPV on head and neck cancer (HNC) wrote, " Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. It is now widely accepted that high-risk HPV is a cause of almost all cervical cancers as well as some forms of HNSCCs. HPV-related HNSCCs are increasing".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of cancers, researchers examined the apoptotic activity of methanol extract of Ashwagandha (MEAG) and in human head and neck squamous cell carcinoma (HNSCC) cells.
In vitro, human head and neck squamous cell carcinoma (HNSCC) cells treated by MEAG showed dose-dependent growth-inhibitory activity involved in caspase-dependent apoptosis.
The inhibition of human head and neck squamous cell carcinoma (HNSCC) was attributed to inducing the loss of mitochondrial membrane, and the release of cytochrome c, accompanied by the activation of caspase 9 the apoptotic pathway.
Furthermore, Bim, truncated Bid (t-Bid), cleaved caspase-8, and death receptor 5 (DR5), associated with pro-apoptotic activity also a significant increase upon the injection of MEAG.
Moreover, the major constituent withaferin A (WA), which is a bioactive component of MEAG, also expressed similar effects to those of MEAG.
Based on the findings, researchers said, " MEAG and WA may be potential natural materials for the treatment of HNSCC.".
Taken together, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of head and neck squamous cell carcinoma (HNSCC), pending the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer activity of Ashwagandha against human head and neck cancer cell lines by Lee HE1, Shin JA1, Jeong JH2, Jeon JG3, Lee MH4, Cho SD. (PubMed)
(2) Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells by Park JW1, Min KJ2, Kim DE1, and Kwon TK. (PubMed)
(3) A Review of HPV-Related Head and Neck Cancer by Kazuhiro Kobayashi,1 Kenji Hisamatsu,1 Natsuko Suzui,1 Akira Hara,1,2 Hiroyuki Tomita,2,* andTatsuhiko Miyazaki. (PMC)
Cancer is a group of diseases associated with cell growth disorderly and uncontrollably in the tissue of a specific organ. Over time cancer can become progressively worse and damage other healthy tissues.
Most cases of cancer start in the cells on the surface in the inner lining tissue of a specific organ, before traveling a distance away to affect other nearby tissue and organ.
Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.
Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. Patients with head and neck cancer at the very early stage are asymptomatic due to the very small size of the tumor.
However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.
The exact causes of head and neck cancer are not identified. However, researchers found that excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust are prevalent factors associated with an increased risk of head and neck cancer.
Dr. Kazuhiro Kobayashi in the investigation of the risk of HPV on head and neck cancer (HNC) wrote, " Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. It is now widely accepted that high-risk HPV is a cause of almost all cervical cancers as well as some forms of HNSCCs. HPV-related HNSCCs are increasing".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of cancers, researchers examined the apoptotic activity of methanol extract of Ashwagandha (MEAG) and in human head and neck squamous cell carcinoma (HNSCC) cells.
In vitro, human head and neck squamous cell carcinoma (HNSCC) cells treated by MEAG showed dose-dependent growth-inhibitory activity involved in caspase-dependent apoptosis.
The inhibition of human head and neck squamous cell carcinoma (HNSCC) was attributed to inducing the loss of mitochondrial membrane, and the release of cytochrome c, accompanied by the activation of caspase 9 the apoptotic pathway.
Furthermore, Bim, truncated Bid (t-Bid), cleaved caspase-8, and death receptor 5 (DR5), associated with pro-apoptotic activity also a significant increase upon the injection of MEAG.
Moreover, the major constituent withaferin A (WA), which is a bioactive component of MEAG, also expressed similar effects to those of MEAG.
Based on the findings, researchers said, " MEAG and WA may be potential natural materials for the treatment of HNSCC.".
Taken together, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of head and neck squamous cell carcinoma (HNSCC), pending the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer activity of Ashwagandha against human head and neck cancer cell lines by Lee HE1, Shin JA1, Jeong JH2, Jeon JG3, Lee MH4, Cho SD. (PubMed)
(2) Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells by Park JW1, Min KJ2, Kim DE1, and Kwon TK. (PubMed)
(3) A Review of HPV-Related Head and Neck Cancer by Kazuhiro Kobayashi,1 Kenji Hisamatsu,1 Natsuko Suzui,1 Akira Hara,1,2 Hiroyuki Tomita,2,* andTatsuhiko Miyazaki. (PMC)
#Tomatoes Enhance the Immune System Against Bacterial and Ciral in the Acute Phase of #Infection, Researchers Suggest
Kyle J. Norton
Carrots and tomatoes and their major bioactive carotenoids may have a profound and positive effect in boosting immunity, some scientists suggested.
The results of the studies were carried out by a number of institutes in numbers of different differentiation, including the Institute of Nutritional Physiology, and the Federal Research Centre for Nutrition.
You can also view the abstract by clicking the links in the resources.
Immunity is a natural defense of an organism with an aim to protect the host to resist a particular infection or toxin through an expression of antibodies or sensitized white blood cells.
Carrot, a root vegetable with orange color is a sub spice of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
Tomato is red, edible fruit, genus Solanum, belongings to the family Solanaceae, native to South America.
Because of their health benefits, tomato is grown worldwide for commercial purpose and often in a greenhouse.
In the investigation of the effect of beta-carotene has been shown to enhance immune functions in humans, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition launched a study to examine whether vegetables rich in carotenoids, such as beta-carotene or lycopene, exert any modulation of immune function in healthy humans.
The blinded, randomized, cross-over study, included male subjects on a low-carotenoid diet who consumed 330 ml/day of either tomato juice(37.0 mg/day lycopene) or carrot juice (27.1 mg/day beta-carotene and 13.1 mg/day alpha-carotene) for 2 weeks with a 2-week depletion period after juice intervention.
Epidemiological studies suggested that consuming carotenoids from food sources may provide a variety of health benefits including a reduced incidence of cancers, risk of cardiovascular disease, and improved eye health,.......
Reading of the immune status was assessed by measuring the related activity of natural killer (NK) cells, secretion of cytokines ( IL-2, IL-4, TNFalpha), and proliferation by activated peripheral blood mononuclear cells((T cells, B cells, NK cells).
Natural killer cells are a type of white blood cells formed as a component of the innate immune system with function in inhibited microorganisms infected cells.
Interleukin-2 (IL-2) is a type of inflammatory cytokine with a function as a signaling molecule in the immune system to protect the body against bacterial and viral in the acute phase of infection.
Interleukin-4 (IL-4) activated by lymphoid cells is the inflammatory cytokine critical for initiating humoral immunity against extracellular pathogens.
Both Interleukin-2 and 4 (IL-2 and 4 ) play an important role in chronic inflammation and wound repair.
Tumor necrosis factor (TNF) including, tumor necrosis factor-alpha, TNFα, cachexin, or cachectin) is a protein (cytokine) involved in systemic inflammation during the acute phase of infection?
At the end of the experiment, researchers found that
* Both juices treated participants demonstrate relatively fast responses in plasma carotenoid concentrations (p < 0.0002) without inducing concomitant changes in immune functions.
* Intake of both tomato and carrot juice displays a significant activity of immunity in the production of IL-2, NK cell cytotoxicity, and lymphocyte proliferation with maximum responses observed during depletion periods.
* Compared to the secretion of other inflammatory cytokines, TNF alpha exerts only at the end of the first intervention period.
* During the course of innervation, both juices show insignificant effects in modulating the secretion of IL-4.
These results suggested that lower plasma carotenoid concentrations in the bloodstream may reduce the immune function in response to diseases caused by bacterial and viral infection, particularly in the acute phase.
Occasional intake of tomato and carrot juice does not enhance body immunity, due to its function in time-delayed modulation of immune functions and its degradation caused by a number of factors, including heat, light, oxygen, acid, transition metal, or interactions with radical species.
The conclusion truly addressed the importance of carotenoids in modulated immune response in the protection of body injury or damage during the acute phase of infection through inhibiting pro-inflammatory expression in the induction of cytotoxity and damage to nearby healthy cells.
Further to reaffirm the effects of the consumption of carotenoid-rich vegetables on the immune system, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition conducted a study of 23 non-smokers, male subjects, who were not restricted in their daily diet, except that they had to abstain from fruit and vegetables high in carotenoids throughout the whole study period with blood collected weekly from subjects after a 12 h fast.
The study was also divided into four periods, each lasting 2 weeks:
* Weeks 1-2: low-carotenoid period;
* Daily consumption of 330 ml tomato juice (40 mg lycopene/d, 1.5 mg beta-carotene/d) (weeks 3-4),
* 330 ml carrot juice (21.6 mg beta-carotene/d, 15.7 mg alpha-carotene/d, 0.5 mg lutein/d) (weeks 5-6)
* 10 g dried spinach powder (11.3 mg lutein/d, 3.1 mg beta-carotene/d) (weeks 7-8).
According to the assessment of T-lymphocyte and secretion of immunoreactive cytokines, lower concentration due to consumption of a low-carotenoid diet exerted a significantly reduced proliferation of function immune system observed in peripheral blood mononuclear cells (PBMC) cultured with concanavalin A.
At the end of the first 2 weeks of tomato juice consumption and until the end of the intervention period, researchers found that intake of tomato juice with abundant carotenoids induced insignificant change in lymphocyte proliferation compared to concentration at the end of the depletion period.
Similarly, the experiment also exerted a strong immune modulated effect in the assessment of the secretion of cytokines interleukin (IL)-2 and -4).
The dietary intervention improved the IL-2 and IL-4 secretion values. however, the levels of IL-2 and IL-4 were significantly suppressed after the low-carotenoid diet.
The results at the end of the period also expressed the similarity of other studies " After carrot juice and spinach powder consumption the cytokine secretion capacity of PBMC was not significantly different from that at the end of the depletion period".
Dr. Watzl B, the lead author after taking into account other co and confounders said, "The results of the present study indicate that a low-carotenoid diet reduces T-lymphocyte functions and the addition of tomato juice restores these functions".
The unexplained changes in the plasma carotenoid concentrations probably severed as an indication that other phytochemicals or other mechanisms in tomato and carrot juice may have a strong implication in modulated immune response other than the cytokine secretion capacity of PBMC.
Taken together, tomato and carrot juice and their bioactive carotenoids may be considered as functional foods in boosting immune function against foreign organisms, particularly, in the acute phase of infection.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G(PubMed)
(2) Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables by Watzl B1, Bub A, Brandstetter BR, Rechkemmer G.(PubMed)
(3) Factors influencing the chemical stability of carotenoids in foods by Boon CS1, McClements DJ, Weiss J, Decker EA(PubMed)
Carrots and tomatoes and their major bioactive carotenoids may have a profound and positive effect in boosting immunity, some scientists suggested.
The results of the studies were carried out by a number of institutes in numbers of different differentiation, including the Institute of Nutritional Physiology, and the Federal Research Centre for Nutrition.
You can also view the abstract by clicking the links in the resources.
Immunity is a natural defense of an organism with an aim to protect the host to resist a particular infection or toxin through an expression of antibodies or sensitized white blood cells.
Carrot, a root vegetable with orange color is a sub spice of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
Tomato is red, edible fruit, genus Solanum, belongings to the family Solanaceae, native to South America.
Because of their health benefits, tomato is grown worldwide for commercial purpose and often in a greenhouse.
In the investigation of the effect of beta-carotene has been shown to enhance immune functions in humans, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition launched a study to examine whether vegetables rich in carotenoids, such as beta-carotene or lycopene, exert any modulation of immune function in healthy humans.
The blinded, randomized, cross-over study, included male subjects on a low-carotenoid diet who consumed 330 ml/day of either tomato juice(37.0 mg/day lycopene) or carrot juice (27.1 mg/day beta-carotene and 13.1 mg/day alpha-carotene) for 2 weeks with a 2-week depletion period after juice intervention.
Epidemiological studies suggested that consuming carotenoids from food sources may provide a variety of health benefits including a reduced incidence of cancers, risk of cardiovascular disease, and improved eye health,.......
Reading of the immune status was assessed by measuring the related activity of natural killer (NK) cells, secretion of cytokines ( IL-2, IL-4, TNFalpha), and proliferation by activated peripheral blood mononuclear cells((T cells, B cells, NK cells).
Natural killer cells are a type of white blood cells formed as a component of the innate immune system with function in inhibited microorganisms infected cells.
Interleukin-2 (IL-2) is a type of inflammatory cytokine with a function as a signaling molecule in the immune system to protect the body against bacterial and viral in the acute phase of infection.
Interleukin-4 (IL-4) activated by lymphoid cells is the inflammatory cytokine critical for initiating humoral immunity against extracellular pathogens.
Both Interleukin-2 and 4 (IL-2 and 4 ) play an important role in chronic inflammation and wound repair.
Tumor necrosis factor (TNF) including, tumor necrosis factor-alpha, TNFα, cachexin, or cachectin) is a protein (cytokine) involved in systemic inflammation during the acute phase of infection?
At the end of the experiment, researchers found that
* Both juices treated participants demonstrate relatively fast responses in plasma carotenoid concentrations (p < 0.0002) without inducing concomitant changes in immune functions.
* Intake of both tomato and carrot juice displays a significant activity of immunity in the production of IL-2, NK cell cytotoxicity, and lymphocyte proliferation with maximum responses observed during depletion periods.
* Compared to the secretion of other inflammatory cytokines, TNF alpha exerts only at the end of the first intervention period.
* During the course of innervation, both juices show insignificant effects in modulating the secretion of IL-4.
These results suggested that lower plasma carotenoid concentrations in the bloodstream may reduce the immune function in response to diseases caused by bacterial and viral infection, particularly in the acute phase.
Occasional intake of tomato and carrot juice does not enhance body immunity, due to its function in time-delayed modulation of immune functions and its degradation caused by a number of factors, including heat, light, oxygen, acid, transition metal, or interactions with radical species.
The conclusion truly addressed the importance of carotenoids in modulated immune response in the protection of body injury or damage during the acute phase of infection through inhibiting pro-inflammatory expression in the induction of cytotoxity and damage to nearby healthy cells.
Further to reaffirm the effects of the consumption of carotenoid-rich vegetables on the immune system, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition conducted a study of 23 non-smokers, male subjects, who were not restricted in their daily diet, except that they had to abstain from fruit and vegetables high in carotenoids throughout the whole study period with blood collected weekly from subjects after a 12 h fast.
The study was also divided into four periods, each lasting 2 weeks:
* Weeks 1-2: low-carotenoid period;
* Daily consumption of 330 ml tomato juice (40 mg lycopene/d, 1.5 mg beta-carotene/d) (weeks 3-4),
* 330 ml carrot juice (21.6 mg beta-carotene/d, 15.7 mg alpha-carotene/d, 0.5 mg lutein/d) (weeks 5-6)
* 10 g dried spinach powder (11.3 mg lutein/d, 3.1 mg beta-carotene/d) (weeks 7-8).
According to the assessment of T-lymphocyte and secretion of immunoreactive cytokines, lower concentration due to consumption of a low-carotenoid diet exerted a significantly reduced proliferation of function immune system observed in peripheral blood mononuclear cells (PBMC) cultured with concanavalin A.
At the end of the first 2 weeks of tomato juice consumption and until the end of the intervention period, researchers found that intake of tomato juice with abundant carotenoids induced insignificant change in lymphocyte proliferation compared to concentration at the end of the depletion period.
Similarly, the experiment also exerted a strong immune modulated effect in the assessment of the secretion of cytokines interleukin (IL)-2 and -4).
The dietary intervention improved the IL-2 and IL-4 secretion values. however, the levels of IL-2 and IL-4 were significantly suppressed after the low-carotenoid diet.
The results at the end of the period also expressed the similarity of other studies " After carrot juice and spinach powder consumption the cytokine secretion capacity of PBMC was not significantly different from that at the end of the depletion period".
Dr. Watzl B, the lead author after taking into account other co and confounders said, "The results of the present study indicate that a low-carotenoid diet reduces T-lymphocyte functions and the addition of tomato juice restores these functions".
The unexplained changes in the plasma carotenoid concentrations probably severed as an indication that other phytochemicals or other mechanisms in tomato and carrot juice may have a strong implication in modulated immune response other than the cytokine secretion capacity of PBMC.
Taken together, tomato and carrot juice and their bioactive carotenoids may be considered as functional foods in boosting immune function against foreign organisms, particularly, in the acute phase of infection.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G(PubMed)
(2) Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables by Watzl B1, Bub A, Brandstetter BR, Rechkemmer G.(PubMed)
(3) Factors influencing the chemical stability of carotenoids in foods by Boon CS1, McClements DJ, Weiss J, Decker EA(PubMed)
#Herbal #Burdock Shows a Significant Effect on Infectious Diseases, According to Studies
Kyle J. Norton
Scientists may have found a herbal plant for the prevention and treatment of bacterial infection with no side effects, according to studies.
Infection is a result of the invasion of microorganisms that have successfully multiplied in the host body and the reaction of host tissues.
Bacteria is a single-cell microorganism. Most bacterias are not harmful, some may also benefit the digestive system. However, 1% of invasive bacteria can make us sick and damage the body tissue, such as bacteria associated with tuberculosis.
There are many ways to cause infection including bacteria passed from person to person, transmitted by bites from insects or animals. and ingesting contaminated food or water.
The most common symptoms of infectious diseases are fever, diarrhea, fatigue, muscle aches, and coughing, depending on the specific area of infection.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
Most bacteria are killed in the first phase of acute infection. In this phase, the immune white blood cells in the first line of defense in responding to the body tissue damage or injury by stimulating the production of proinflammatory cytokines to kill off all invasive pathogens on the site of damage.
However, overexpression of proinflammatory cytokines in most cases can destroy the nearby healthy cells, leading to the formation of scars as seen in liver infection.
What contributes to the overexpression of proinflammatory and underexpression of anti-inflammatory cytokines of the body in the initiation of chronic inflammatory diseases?
Dr. Thomas W. McDade and colleagues in the investigation of the role of proinflammatory cytokines in the risk of infection explained, "The metabolic syndrome may be characterized by dysregulated inflammation, in which an important anti-inflammatory signal is absent. Similarly, in a prospective study of patients with acute coronary syndromes, baseline IL-10 concentration was a significant predictor of death or myocardial infarction during 6 months of follow-up, ......high IL-10 experienced an adverse outcome, compared to 21.8% of patients with high CRP but low IL-10
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.
The plant has been used for thousands of years in China medicine as a diuretic, diaphoretic, and blood-purifying agent and to treat wounds and infections stomach ulcers, and other digestive problems.
With an aim to discover natural bio components from plants with antibacterial activity on endodontic microbiota for the new therapies, researchers evaluated the antibacterial activity of a phytotherapeutic agent prepared from an ethyl acetate fraction (AcOEt) extracted from Arctium lappa.
A total of 27 maxillary canines with a mixed bacterial suspension of Pseudomonas aeruginosa, Escherichia coli, Lactobacillus acidophilus, Streptococcus mutans Candida albicans were included in the study.
The teeth were divided into three groups and their canals were filled with group 1, calcium hydroxide and propylene glycol; group 2, a paste containing AcOEt fraction of A. lappa (Burdock) and propylene glycol; group 3, propylene glycol (control).
At 7, 14, and 30 days, three teeth from each group opened, researchers found that mild bacterial growth was found in group 1 at all time intervals; in group 2 there was severe growth at 7 days, but no growth at 14 and 30 days.
These results indicated a significant antibacterial effect of AcOEt fraction of A. lappa in inhibiting the growth of all the microorganisms.
Furthermore, in vitro, the antimicrobial activity of rough extracts from leaves of Arctium lappa showed inhibition of Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Candida albicans selectively to specific target microorganisms.
In other words, each constituent in the extract of Burdock inhibited only a certain type of endodontic pathogens without affecting others.
Dr.Pereira JV, the lead author said, "The Arctium lappa constituents exhibited a great microbial inhibition potential against the tested endodontic pathogens".
More importantly, in the review of the antimicrobial activity against bacteria and yeasts of extracts of 13 Brazilian medicinal plants, researchers found that only 10 plant extracts showed varied levels of antibacterial activity.
Arctium lappa exerted some degree of antibacterial activity compared to other plants, including Mikania glomerata, Sambucus canadensis, Plantago major, and Erythrina species.
Burdock was one of 5 plants belonging to the Asteraceae family that demonstrated Rf values similar to the antibacterial compounds visible on bioautogram.
The finding strongly suggested Burdock and the other 4 plants in the Asteraceae family may be used for the treatment of various infectious diseases.
Taken altogether, herbal Burdock may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of infectious diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro evaluation of the antibacterial activity of Arctium lappa as a phytotherapeutic agent used in intracanal dressings by Gentil M, Pereira JV, Sousa YT, Pietro R, Neto MD, Vansan LP, de Castro França S.(PubMed)
(2) Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections by Pereira JV, Bergamo DC, Pereira JO, França Sde C, Pietro RC, Silva-Sousa YT.(PubMed)
(3) Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases by Holetz FB, Pessini GL, Sanches NR, Cortez DA, Nakamura CV, Filho BP. (PubMed)
(4) Comparative insights into the regulation of inflammation: Levels and predictors of interleukin 6 and interleukin 10 in young adults in the Philippines by Thomas W. McDade,
1,2 Paula S. Tallman,1 Linda S. Adair,3 Borja Judith,4 and Christopher W. Kuzawa. (PMC)
Scientists may have found a herbal plant for the prevention and treatment of bacterial infection with no side effects, according to studies.
Infection is a result of the invasion of microorganisms that have successfully multiplied in the host body and the reaction of host tissues.
Bacteria is a single-cell microorganism. Most bacterias are not harmful, some may also benefit the digestive system. However, 1% of invasive bacteria can make us sick and damage the body tissue, such as bacteria associated with tuberculosis.
There are many ways to cause infection including bacteria passed from person to person, transmitted by bites from insects or animals. and ingesting contaminated food or water.
The most common symptoms of infectious diseases are fever, diarrhea, fatigue, muscle aches, and coughing, depending on the specific area of infection.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
Most bacteria are killed in the first phase of acute infection. In this phase, the immune white blood cells in the first line of defense in responding to the body tissue damage or injury by stimulating the production of proinflammatory cytokines to kill off all invasive pathogens on the site of damage.
However, overexpression of proinflammatory cytokines in most cases can destroy the nearby healthy cells, leading to the formation of scars as seen in liver infection.
What contributes to the overexpression of proinflammatory and underexpression of anti-inflammatory cytokines of the body in the initiation of chronic inflammatory diseases?
Dr. Thomas W. McDade and colleagues in the investigation of the role of proinflammatory cytokines in the risk of infection explained, "The metabolic syndrome may be characterized by dysregulated inflammation, in which an important anti-inflammatory signal is absent. Similarly, in a prospective study of patients with acute coronary syndromes, baseline IL-10 concentration was a significant predictor of death or myocardial infarction during 6 months of follow-up, ......high IL-10 experienced an adverse outcome, compared to 21.8% of patients with high CRP but low IL-10
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.
The plant has been used for thousands of years in China medicine as a diuretic, diaphoretic, and blood-purifying agent and to treat wounds and infections stomach ulcers, and other digestive problems.
With an aim to discover natural bio components from plants with antibacterial activity on endodontic microbiota for the new therapies, researchers evaluated the antibacterial activity of a phytotherapeutic agent prepared from an ethyl acetate fraction (AcOEt) extracted from Arctium lappa.
A total of 27 maxillary canines with a mixed bacterial suspension of Pseudomonas aeruginosa, Escherichia coli, Lactobacillus acidophilus, Streptococcus mutans Candida albicans were included in the study.
The teeth were divided into three groups and their canals were filled with group 1, calcium hydroxide and propylene glycol; group 2, a paste containing AcOEt fraction of A. lappa (Burdock) and propylene glycol; group 3, propylene glycol (control).
At 7, 14, and 30 days, three teeth from each group opened, researchers found that mild bacterial growth was found in group 1 at all time intervals; in group 2 there was severe growth at 7 days, but no growth at 14 and 30 days.
These results indicated a significant antibacterial effect of AcOEt fraction of A. lappa in inhibiting the growth of all the microorganisms.
Furthermore, in vitro, the antimicrobial activity of rough extracts from leaves of Arctium lappa showed inhibition of Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Candida albicans selectively to specific target microorganisms.
In other words, each constituent in the extract of Burdock inhibited only a certain type of endodontic pathogens without affecting others.
Dr.Pereira JV, the lead author said, "The Arctium lappa constituents exhibited a great microbial inhibition potential against the tested endodontic pathogens".
More importantly, in the review of the antimicrobial activity against bacteria and yeasts of extracts of 13 Brazilian medicinal plants, researchers found that only 10 plant extracts showed varied levels of antibacterial activity.
Arctium lappa exerted some degree of antibacterial activity compared to other plants, including Mikania glomerata, Sambucus canadensis, Plantago major, and Erythrina species.
Burdock was one of 5 plants belonging to the Asteraceae family that demonstrated Rf values similar to the antibacterial compounds visible on bioautogram.
The finding strongly suggested Burdock and the other 4 plants in the Asteraceae family may be used for the treatment of various infectious diseases.
Taken altogether, herbal Burdock may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of infectious diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro evaluation of the antibacterial activity of Arctium lappa as a phytotherapeutic agent used in intracanal dressings by Gentil M, Pereira JV, Sousa YT, Pietro R, Neto MD, Vansan LP, de Castro França S.(PubMed)
(2) Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections by Pereira JV, Bergamo DC, Pereira JO, França Sde C, Pietro RC, Silva-Sousa YT.(PubMed)
(3) Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases by Holetz FB, Pessini GL, Sanches NR, Cortez DA, Nakamura CV, Filho BP. (PubMed)
(4) Comparative insights into the regulation of inflammation: Levels and predictors of interleukin 6 and interleukin 10 in young adults in the Philippines by Thomas W. McDade,
1,2 Paula S. Tallman,1 Linda S. Adair,3 Borja Judith,4 and Christopher W. Kuzawa. (PMC)#Anthocyanin-Rich #Bilberry #Extract inhibits #SkinDiseases Associated with #ChronicPruritic Symptoms, According to Studies
Kyle J. Norton
Pruritus is a severe itching of the skin, as a symptom of various ailments. It is a frequent complaint heard by dermatologists and primary care physicians.
According to the statistics provided by Dr. Elke Weisshaar and Dr. Uwe Matterne, in children, pruritus is a cardinal symptom of atopic eczema (atopic dermatitis)associated with the prevalent risk between 6.1% and 22.3% in the Western countries.
There are many causes associated with the itching skin including aging that worsened dry skin condition, dry skin, eczema, psoriasis, scabies, burns, scars, insect bites, and hives.and diseases associated with the liver and kidney
Most symptoms of pruritus are due to scratching, including skin redness, bumps, cracks, and scaly skin, depending on the causes of the symptoms.
For some instances, an allergic reaction can induce pruritus involved in touching clothing, pets, chemicals, soaps, and cosmetics, and foods caused by an overreaction of the immune system in the production of cytokines against allergens.
Some researchers suggested that some people may experience an itching feeling with no physical cause. And patients with depression anxiety obsessive-compulsive disorder have been found to have an urge to scratch.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In finding a potential compound for the treatment of pruritus, researchers at Chiba Univ examined the bilberry anthocyanins' antipruritic effect in a mouse model of allergic contact dermatitis by comparing anthocyanin-rich quality-controlled bilberry extract and anthocyanidin-rich degraded extract.
The study included BALB/c mice with allergic contact dermatitis induced by 4 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) were administered Bilberon-25 orally for 4 weeks after sensitization with TNCB.
Treatment with non-heated Bilberon-25 significantly attenuated the TNCB-induced increased scratching behavior, whereas treatment with 2 h-heated Bilberon-25 did not.
300 μg/mL nonheated Bilberon-25 showed significant inhibition of degranulation in RBL-2H3 mast cells, whereas 2 h-heated Bilberon-25 had no effect at any concentration.
Further differentiation of the results, researchers found that the efficacy of nonheated Bilberon-25 was attributed to the inhibitory effect of bilberry anthocyanins on pruritus mediated, at least in part, on mast cell degranulation.
More precisely, Dr. Yamaura K, the lead scientist said, "The anthocyanin-rich but not anthocyanidin-rich bilberry extract may be a useful dietary supplement for skin diseases involving pruritic symptoms, such as chronic allergic contact dermatitis, atopic dermatitis, and rhinitis".
Furthermore, in a mouse model induced chronic allergic contact dermatitic researchers once again examined the bilberry extract (Bilberon-25) in the alleviation of pruritus.
The study included BALB/c mice with chronic allergic contact dermatitis induced by 3 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) were administered Bilberon-25 orally for 3 weeks after sensitization with TNCB.
During the study, treatment with Bilberon-25 significantly attenuated the TNCB-induced increased scratching behavior, but dexamethasone did not.
Both dexamethasone and Bilberon-25 showed a significant amelioration of ear swelling.
Based on these results, researchers wrote in the final report, "Anthocyanins from bilberry might be beneficial for the treatment of chronic pruritus which can occur in patients with inflammatory skin diseases such as atopic dermatitis".
Taken altogether, bilberry processed with a high amount of anthocyanins may be considered a functional food for the treatment of chronic pruritus with no side effects, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation by Yamaura K1, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K. (PubMed)
(2) Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis by Yamaura K1, Shimada M, Ueno K. (PubMed)
(3) Epidemiology of Itch by Elke Weisshaar and Uwe Matterne.(NCBI)
Pruritus is a severe itching of the skin, as a symptom of various ailments. It is a frequent complaint heard by dermatologists and primary care physicians.
According to the statistics provided by Dr. Elke Weisshaar and Dr. Uwe Matterne, in children, pruritus is a cardinal symptom of atopic eczema (atopic dermatitis)associated with the prevalent risk between 6.1% and 22.3% in the Western countries.
There are many causes associated with the itching skin including aging that worsened dry skin condition, dry skin, eczema, psoriasis, scabies, burns, scars, insect bites, and hives.and diseases associated with the liver and kidney
Most symptoms of pruritus are due to scratching, including skin redness, bumps, cracks, and scaly skin, depending on the causes of the symptoms.
For some instances, an allergic reaction can induce pruritus involved in touching clothing, pets, chemicals, soaps, and cosmetics, and foods caused by an overreaction of the immune system in the production of cytokines against allergens.
Some researchers suggested that some people may experience an itching feeling with no physical cause. And patients with depression anxiety obsessive-compulsive disorder have been found to have an urge to scratch.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In finding a potential compound for the treatment of pruritus, researchers at Chiba Univ examined the bilberry anthocyanins' antipruritic effect in a mouse model of allergic contact dermatitis by comparing anthocyanin-rich quality-controlled bilberry extract and anthocyanidin-rich degraded extract.
The study included BALB/c mice with allergic contact dermatitis induced by 4 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) were administered Bilberon-25 orally for 4 weeks after sensitization with TNCB.
Treatment with non-heated Bilberon-25 significantly attenuated the TNCB-induced increased scratching behavior, whereas treatment with 2 h-heated Bilberon-25 did not.
300 μg/mL nonheated Bilberon-25 showed significant inhibition of degranulation in RBL-2H3 mast cells, whereas 2 h-heated Bilberon-25 had no effect at any concentration.
Further differentiation of the results, researchers found that the efficacy of nonheated Bilberon-25 was attributed to the inhibitory effect of bilberry anthocyanins on pruritus mediated, at least in part, on mast cell degranulation.
More precisely, Dr. Yamaura K, the lead scientist said, "The anthocyanin-rich but not anthocyanidin-rich bilberry extract may be a useful dietary supplement for skin diseases involving pruritic symptoms, such as chronic allergic contact dermatitis, atopic dermatitis, and rhinitis".
Furthermore, in a mouse model induced chronic allergic contact dermatitic researchers once again examined the bilberry extract (Bilberon-25) in the alleviation of pruritus.
The study included BALB/c mice with chronic allergic contact dermatitis induced by 3 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) were administered Bilberon-25 orally for 3 weeks after sensitization with TNCB.
During the study, treatment with Bilberon-25 significantly attenuated the TNCB-induced increased scratching behavior, but dexamethasone did not.
Both dexamethasone and Bilberon-25 showed a significant amelioration of ear swelling.
Based on these results, researchers wrote in the final report, "Anthocyanins from bilberry might be beneficial for the treatment of chronic pruritus which can occur in patients with inflammatory skin diseases such as atopic dermatitis".
Taken altogether, bilberry processed with a high amount of anthocyanins may be considered a functional food for the treatment of chronic pruritus with no side effects, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation by Yamaura K1, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K. (PubMed)
(2) Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis by Yamaura K1, Shimada M, Ueno K. (PubMed)
(3) Epidemiology of Itch by Elke Weisshaar and Uwe Matterne.(NCBI)
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