#Herbal #Ginger's #Gingerol An Inhibitory Effect on #RetinoblastomaCells, Reserachers Show

Kyle J. Norton

Scientists may have a pungent spice that processes the potential to treat retinoblastoma, according to studies.
Retinoblastoma (Rb) is a rare form of cancer that rapidly developed due to the production of the immature cells of a retina. The retina, composed of many layers, is the sensory membrane that lines the inner surface of the back of the eyeball. Most cases of retinoblastoma (Rb) are found in young children.

According to the statistics, provided by the American Cancer Society, approximately 200 to 300 children are diagnosed with retinoblastoma each year in the United States. The average age of children affected by retinoblastoma is 2. The disease rarely occurs in children older than 6.

Retinoblastoma diagnosed at the early stage is curable. However, the advanced form of retinoblastoma can be life-threatening.

Epidemiological studies suggested that age and genetic preposition are the 2 most common risk factors associated with the onset of retinoblastoma.

Some researchers suggested that children inherited gene Rb may be associated with the risk of retinoblastoma development.

Dr. Jun Yun and colleagues in examing the epidemiology and Rb1 gene of retinoblastoma said, "Retinoblastoma (Rb) is the most common eye cancer in children and it can be inherited".


And, "In children with the heritable genetic form of Rb, there is a mutation on chromosome 13, called the retinoblastoma 1 (Rb1) gene. Early diagnosis and intervention are critical to the successful treatment of the Rb."

The results strongly suggested that the mutation gene Prevents the protein to carry the function as a negative regulator of the cell cycle, leading to the unbalance between cell growth and development, a major cause of retinoblastoma.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists may have found a natural ingredient for the treatment of retinoblastoma with no side effects by examing the gingerol anti-cancer activity on retinoblastoma cancer cells (RB355 Cell Line).

Application of gingerol exerted dose-dependent and time-dependent growth inhibitory effects against the retinoblastoma cells.

The growth inhibitory effects of gingerol were less pronounced against normal fr2 cells. In other words, ginger application inhibited the growth of retinoblastoma cells without affecting the normal epithelial fr2 cells.

Compared to the untreated control cells, gingerol-treated cells at concentrations of 25, 75, and 150 μM had drastic changes in cell morphology, including rounding and withering of cells, with disorganized cell layers, the indications of rupture of the cell membrane, and cellular damage.

Furthermore, untreated cells showed normal green fluorescence and gingerol-treated cells showed yellow/red fluorescence captured and classified by the image test.

Moreover, gingerol also displayed an inhibitory activity at a dose-dependent in the G2/M phase cell cycle arrest on RB355 retinoblastoma cells.

In-depth analysis, researchers found that the kitchen spice at concentration-dependent also inhibits the protein expressions involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking,

Dr. Bo Meng and colleagues wrote in the final report, "Gingerol exhibits potent anticancer effects in RB355 human retinoblastoma cancer cells and these effects were mediated via apoptosis induction, cell cycle arrest, and modulation of the PI3K/Akt signaling pathway".

Where PI3K/Akt signaling pathway is an intracellular signaling pathway associated with the cell division cycle.

Taken together, ginger processed abundantly bioactive compound gingerol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of retinoblastoma, pending the confirmation of a large sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal lth And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Anticancer Effects of Gingerol in Retinoblastoma Cancer Cells (RB355 Cell Line) Are Mediated via Apoptosis Induction, Cell Cycle Arrest and Upregulation of PI3K/Akt Signaling Pathway by Bo Meng,1,B,D Hongyi Ii,2,B,D,E Wei Qu,1,C,D,E and Huiping Yuan1,A,C,G. (PMC)
(2) Epidemiology and Rb1 gene of retinoblastoma by Jun Yun,1 Yang Li,2 Chang-Tai Xu,3 and Bo-Rong Pan. (PMC)

#Lycopene From #CookedTomato Exhibits Anti #Osteoporosis Induced by #Osteoclast-Mediated Bone Resorption, Scientists Say

Kyle J. Norton

Osteoporosis is a condition associated with low bone mass and deterioration of bone tissue.
The disease is most common in older adults as the result of the bone made by the body can not cover the bone loss due to an increased serum of osteoclast mediator involved in bone resorption.

Consequently, the bone in osteoporotic patients becomes weak and breaks easily from a fall.
Believe it or not, in serious cases, bone can also be broken due to sneezing or minor bumps.

According to the statistics provided by the International Osteoporosis Foundation, approximately 44 million U.S. women and men aged 50 and older suffer from osteoporosis and low bone mass.

There are over 200 million women worldwide affected by osteoporosis, including one-tenth of women aged 60, one-fifth of women aged 70, two-fifths of women aged 80, and two-thirds of women aged 90.

The most common cause of osteoporosis is the reduced production of hormones, particularly estrogen in women and androgen in men due to aging or other conditions such as medical condition.

(Diseases associated with osteoporosis include rheumatoid arthritis and rheumatological conditions, steroid hormone Deficiency, primary hyperparathyroidism, diabetes, and chronic kidney and liver disease).

In older women, menopause accompanied by lower estrogen levels are found in patients with osteoporosis.

According to epidemiological studies, being a woman and being older, family history of osteoporosis, having a small frame, and structure, having ethnicity, follow a long-term calcium-deficient diet are some of the prevalent factors of disease.

However, out of the aforementioned risk factors, some researchers suggested smoking may be one of the major culprits in inducing the risk of the condition in Southeast Asain.

The research team at the University of Pennsylvania in the study of how smoking causes osteoporosis, said, ""It has been known from many epidemiological studies that smokers usually show bone loss, and their bone density is much lower than non-smokers' bone density,"

and "What we show here is that excessive formation of osteoclasts by cigarette chemicals causes bone loss".

In other words, if you are a smoker, your risk of osteoporosis is increased substantially compared to a non-smoked individual.

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential compound for the treatment of osteoporosis against bone resorption, researchers examined lycopene a carotenoid commonly found in tomatoes and tomato products against osteoporosis risk.

The study included 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
According to the results of sample analysis, a one-month lycopene-depletion period diet showed a significantly decreased serum lycopene, lutein/zeaxanthin, and levels of antioxidants glutathione peroxidase (GPx).
Furthermore, the lycopene restriction diet not only increased lipid and protein oxidation but also depression of levels of antioxidant enzymes superoxide dismutase (SOD), and catalase (CAT), significantly.

These results lead to a significant increase in the levels of cross-linked N-telopeptide of type I collagen (NTx), a marker of osteoclast-mediated bone resorption.

In other words, tomatoes restrictive diet increased the risk of osteoporosis in postmenopausal women.

In order to reveal more information about the tomato effect in osteoporosis, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters, resulting in decreased bone turnover markers, thus reducing the risk of osteoporosis in postmenopausal women.

The study included 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption, randomly divided into group consumed either (N = 15/group): (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.

According to the blood sample collected at the end of the experiment, consumed juice or lycopene capsules treated groups for 4 months significantly increased serum lycopene compared to placebo.

Moreover, consumed juice or lycopene capsules treated groups for 4 months exerted a similar effect as the aforementioned study in significantly increasing the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation and NTx compared to the placebo group.

Based on the findings, researchers said, "The daily consumption of lycopene may be important as it acts as an antioxidant to decrease bone resorption in postmenopausal women and may, therefore, be beneficial in reducing the risk of osteoporosis".

Taken together, tomatoes and their major bioactive compound lycopene may be considered remedies for the prevention and treatment of osteoporosis, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such asthe international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Researchers pinpoint how smoking causes osteoporosis by the University of Pennsylvania. (Medical Press)

#Vegetables and #Fruits Intake Daily and Regularly Inhibit the Risk of Subtypes of #Esophagealcancer and #GastricCancer in Vitro

Kyle J. Norton

Esophagus, an organ in vertebrates, is the tube that leads food from the pharynx to the stomach.
Esophageal cancer is a medical condition that starts in the cells on the surface of the inner lining of the esophageal tissue caused by the alternation of cell DNA.

The most common types of esophageal cancer are adenocarcinoma and squamous cell carcinoma.

Adenocarcinoma arises from the glands in the mucosa, and squamous cell carcinoma begins in flat cells lining the esophagus.

The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.

Stomach cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

According to the Cancer Genome Atlas Research Network Group (TCGA), gastric cancer can be classified into four subtypes: EBV-positive tumors, microsatellite unstable tumors (MSI), genomically stable tumors (GS) and tumors with chromosomal instability (CIN).


The stages of both subtypes of esophageal and gastric cancer can be classified into
1. Stage 0,
If the cancerous cell has not penetrated deeper tissue but on the surface of the inside lining of the stomach.
2. Stage I
In stage, I, The cancerous cells are no longer on the surface but have invaded into deep the inside stomach lining but are still completely inside the stomach
a. Stage IA
The cancer is not ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
a.1. Stage IA1:
The spreading is not less than 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
a.2. Stage IA2:
The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.b.
Stage IB:
Cancer in this stage has invaded the connective tissue, & less than 5mm (1/5 inch).
b.1. Stage IB1:
Cancer is 4 cm large (1 3/4 inches).
b.2. Stage IB2:
Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)

3. Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the stomach lining.

4. Stage III
In this stage, cancerous cells have spread to the tissues immediately surrounding the stomach lining.

5. Stage IVIn this stage, cancerous cells have spread to the tissues immediately outside of the stomach to distant parts of the body.

In findings of a natural whole for the prevention of subtypes of esophageal and gastric cancer, researchers examined the association between vegetables and fruits consumption and the risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA).

According to the results of the Netherlands Cohort Study in 1986, 120,852 Dutch men and women aged 55-69 filled out a questionnaire on diet and other cancer risk factors, and after 16.3 years of follow-up,

* Total vegetable consumption was nonsignificantly inversely associated with EAC and ESCC risk, but not with GCA and GNCA risk.
More precisely, Significant inverse associations were observed forraw vegetables and EAC risk [RR per 25 g/day: 0.81, 95% confidence interval (CI) 0.68-0.98], and Brassica vegetables and GCA risk (RR per 25 g/day: 0.72, 95% CI 0.54-0.95).

* Total fruit consumption was associated with a nonsignificantly decreased EAC risk.

Particularly, citrus fruits were inversely associated with EAC and GCA risk (RRs for highest vs. lowest intake: 0.55, 95% CI 0.31-0.98 and 0.38, 95% CI 0.21-0.69, respectively).

More Profoundly, for current smokers, vegetables and possibly also fruit intake was inversely associated with ESCC and EAC risk.

Based on the results, researchers wrote, "Consumption of (specific groups of) vegetables and fruits may protect against subtypes of esophageal and gastric cancer".

Taken altogether, regular intake of vegetables and fruits may prevent the onset of subtypes of esophageal and gastric cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study by Steevens J1, Schouten LJ, Goldbohm RA, van den Brandt PA. (PubMed)

#Omega3 Fatty Acids Inhibit Parameters Associated with the Risk of #Weightgain and #Obesity, According to Studies

Kyle J. Norton

Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.

In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

Similar to other chronic medical conditions including diabetes, cardiovascular disease, or high blood pressure, obesity has recently become a serious health problem.

Epidemiologically, obesity does not only have serious effects on physical and psychological health but also has a strongly negative impact on the patient's quality of life.

Today, the widespread obesity in the US population has caused a significant economic impact on the U.S. healthcare system, including direct and indirect costs.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the treatment of diseases associated with obesity, researchers examined the Omega 3 fatty acid activity in the prevalence of overweight and obesity.

According to the results of the study,* Omega-6 and omega-3 fatty acids elicit divergent effects on body fat gain through mechanisms associated with the risk of weight gain, including adipogenesis, browning of adipose tissue, lipid homeostasis, and brain-gut-adipose tissue axis.

* Omega 3 fatty acids also modulated the immune response in the stimulation of the production of pro-inflammatory cytokines.

* Furthermore, the risk of obesity is increased if the level of omega-6 fatty acids and the omega-6/omega-3 ratio was increased in red blood cell (RBC) membrane phospholipids.

* However, the high omega-3 RBC membrane phospholipids were associated with a decreased risk of obesity.

Moreover, researchers said, "In addition to absolute amounts of omega-6 and omega-3 fatty acid intake, the omega-6/omega-3 ratio plays an important role in increasing the development of obesity via both AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). A balanced omega-6/omega-3 ratio is important for health and in the prevention and management of obesity".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of obesity, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity by Simopoulos AP. (PubMed)

#Herbal #Artichoke #Reduces #Plasma Lipid Levels by Inhibiting the Levels of Both Total and LDL-C, and Triglycerides, According to Studies

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have a whole herb for the prevention and treatment of overexpression of triglycerides, according to studies.

Triglycerides are body fat found in humans derived from glycerol and saturated, monounsaturated, and polyunsaturated fatty acids.

The triglycerides are stored in your fat cells for energy in the future when the body needs it.

Unlike cholesterol produced by the liver and absorbed through diet to build cell walls, produce steroid hormone and vitamin D, and aid digestion, the primary triglycerides function is to store as unused calories and provide your body with energy.

From a health perspective, the levels of triglycerides can affect your health and risk of cardiovascular disease.
1. Normal, if your level is less than 150 milligrams per deciliter (mg/dL), or less than 1.7 millimoles per liter (mmol/L)
2. Borderline high if your level is between 150 and 199 mg/dL (1.8 and 2.2 mmol/L)
3. High, if your level is between 200 and 499 mg/dL (2.3 and 5.6 mmol)
4. Very high, if your level is above 500 mg/dL (above 5.7 mmol/L)

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural compound for the treatment of obesity investigated the artichoke extract anti overexpression of triglycerides by reviewing the medical literature online.

From the databases of PubMed-Medline, Scopus, Web of Science and Google Scholar databases up to March 28, 2017, RCTs satisfied the standard criteria, and guidelines were selected for the investigation of the impact of artichoke extracts on plasma lipid levels.

According to the Meta-analysis of data from 9 trials including 702 subjects artichoke extract showed significant activity against the overexpression of plasma concentrations, including lowering the triglycerides by -9.2 mg/dL.

The injection of artichoke extract according to the selected studies did not exert any impact on the levels of high-density lipoprotein, compared to the strong effect on lowering the levels of low-density lipoprotein.

These results suggested that the artichoke supplement reduced plasma lipid levels by inhibiting the levels of both total and LDL-C, and triglycerides.


Furthermore, in order to reveal more details of the artichoke effect on triglycerides, researchers examined fecal excretion of neutral bile acids and sterols in subjects after the artichoke leaf extract (ALE) intake.

The animal model study included 64 Golden Syrian hamsters (8 weeks old) fed randomly either a control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.

According to the observation up to day 21, ALE injection showed no significant changes in plasma lipid levels, including non-HDL cholesterol triglycerides or fecal-neutral sterols.


However, after day 42, ALE exerted a clinical significance in lowing the levels of triglycerides by 22% in males and 29% in female hamsters, compared to control.

The findings strongly suggested that ALE processes anti-triglycerides accumulation by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days.

According to the accumulated information, it is safe to say that artichoke may be considered a functional remedy for the treatment of elevated non-HDL cholesterol triglycerides with no side effects, pending the validation of a larger sample size and multicenter human study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(2) Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis by Sahebkar A1, Pirro M2, Banach M3,4, Mikhailidis DP5, Atkin SL6, Cicero AFG. (PubMed)
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S. (PubMed)

Some Amazing #HealthBenefits of #Omega3 Fatty Acids, According to Studies

Kyle J. Norton

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the prevention of diseases, researchers examined the myriad health benefits of omega-3 PUFAs.

According to the search of epidemiological studies, omega-3 PUFAs exerted a strong activity against the risk and treatment of
* Cardiovascular diseases
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaque build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
* Diabetes
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

The most common types of diabetes are
**Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.


** Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

* Cancer
Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
* Alzheimer's disease
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.

* Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

* Depression
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

Furthermore, omega-3 fatty acids improved fetal health including a slight increase a baby’s weight at birth and the length of time the baby is in the womb, both of which may be beneficial. Breast milk contains DHA.

However, researchers explained, "There are also some controversies about their efficacy and certain benefits to human health".

Taken together, Omega-3 fatty acids may be considered a functional food for the promotion of health benefits, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits by Shahidi F1, Ambigaipalan P. (PubMed)

#Ginger Induces Airway Smooth Muscle Relaxation to Decrease the Symptoms of #Asthma, Researchers Say

Kyle J. Norton

Scientists may have found a pungent spice for the treatment of airway hyperresponsiveness in asthmatic patients, according to the studies.

Airway hyperresponsiveness is a hallmark of asthma and chronic obstructive pulmonary disease caused by the exaggerated response of the airways to nonspecific stimuli.

Asthma is a respiratory disease associated caused by spasms in the bronchi of the lungs, leading to symptoms of difficulty in breathing. In other words, asthma is a disease as the result of an allergic reaction or other forms of hypersensitivity.

Asthma attacks can be dangerous, if not treated immediately. In an asthma attack, the airways become swollen and inflamed, leading to the overproduction of mucus, which causes the narrowing of the airway.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), 1 in the US, or more than 26 million people have asthma, with 8.3 percent of adults and 8.3 percent of children.

The exact cause of asthma is not known. But exposure to various irritants and substances that trigger allergies (allergens), including airborne substances, such as pollen, dust mites, mold spores, and pet dander are the most common prevalent risk factors.

Some researchers suggested that widespread obesity may be correlated to the rise of asthmatic cases over the past few decades.

Dr. Sveta Mohanan and colleagues in examing the pathophysiology and implications of obesity and asthma in primary care centers wrote, "Mainstream clinical practice has yet to adopt aggressive management of obesity as a modifiable risk factor in asthma care, as is the case with a risk factor like tobacco or allergen exposure".

And, "Our review suggests that evidence of chronic inflammatory response linking obesity and asthma indicates a need to address obesity during asthma management, possibly using patient-centered approaches such as shared decision making".

The findings strongly indicated a link between obesity and the risk of asthma.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of respiratory infection with no side effects evaluated the ginger activity on airway smooth muscle relaxation and calcium regulation.

In isolated human ASM, researchers found that ginger caused significant and rapid relaxation.

In both guinea pig and human tracheas, injection of [6]-gingerol, [8]-gingerol, and [6]-shogaol induced rapid relaxation of precontracted ASM (100–300 μM) compared to [10]-gingerol failure in the induction of relaxation.

In human ASM cells, exposure to [6]-gingerol, [8]-gingerol, and [6]-shogaol, blunted subsequent Ca2+ responses to bradykinin (10 μM) and S-(−)-Bay K 8644 (10 μM) associated with the reuptake in airway smooth muscle compared to no response of the [10]-gingerol at a concentration of 100 μM.

Furthermore, in A/J mice, the nebulization of [8]-gingerol (100 μM), 15 minutes before methacholine challenge, significantly attenuated airway resistance, compared with vehicle.

These results suggested that not all compounds from ginger experts have a respiratory protective effect through inducing airway smooth muscle relaxation, thus decreasing the symptoms of asthma.

Dr. Elizabeth A. Townsend, the lead scientist said, "These novel data show that ginger and its isolated active components, [6]-gingerol, [8]-gingerol, and [6]-shogaol, relax ASM, and [8]-gingerol attenuates airway hyperresponsiveness, in part by altering [Ca2+] I regulation".

In order to reveal more information about ginger relaxed airway smooth muscle (ASM) activity, researchers examined the 6-gingerol, 8-gingerol, or 6-shogaol bioactive compounds found in ginger potentiate β-agonist-induced ASM relaxation.


In human ASM, the airway issues were relaxed dose-dependently with β-agonist, isoproterenol, in the presence of vehicles, 6-gingerol, 8-gingerol, or 6-shogaol (100 μM).


Significant potentiation of isoproterenol-induced relaxation was observed with each of the ginger constituents. 6-Shogaol showed the largest shift in isoproterenol half-maximal effective concentration.


6-Gingerol, 8-gingerol, or 6-shogaol significantly inhibited PDE4D-involved smooth muscle contractility, whereas 8-gingerol and 6-shogaol also inhibited phospholipase C β activity also involved constriction of smooth muscle.

The findings strongly suggested that Isolated components of ginger potentiate βagonist-induced relaxation in human ASM.

Taken together, ginger processed a number of bioactive compounds that may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of asthmatic symptoms through attenuating air hyperresponsiveness.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Effects of Ginger and Its Constituents on Airway Smooth Muscle Relaxation and Calcium Regulation by Elizabeth A. Townsend,1 Matthew E. Siviski,1 Yi Zhang,1 Carrie Xu,1 Bhupinder Hoonjan,2 and Charles W. Emala. (PMC)
(2) Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins by Townsend EA1, Zhang Y, Xu C, Wakita R, Emala CW. (PubMed)
(3) Obesity and asthma: Pathophysiology and implications for diagnosis and management in primary care. by Sveta Mohanan, Hazel Tapp, Andrew McWilliams, and Michael Dulin. (PubMed)