Some Amazing #HealthBenefits of #Omega3 Fatty Acids, According to Studies

Kyle J. Norton

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the prevention of diseases, researchers examined the myriad health benefits of omega-3 PUFAs.

According to the search of epidemiological studies, omega-3 PUFAs exerted a strong activity against the risk and treatment of
* Cardiovascular diseases
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.

The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaque build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
* Diabetes
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

The most common types of diabetes are
**Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.


** Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

* Cancer
Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
* Alzheimer's disease
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.

* Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

* Depression
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

Furthermore, omega-3 fatty acids improved fetal health including a slight increase a baby’s weight at birth and the length of time the baby is in the womb, both of which may be beneficial. Breast milk contains DHA.

However, researchers explained, "There are also some controversies about their efficacy and certain benefits to human health".

Taken together, Omega-3 fatty acids may be considered a functional food for the promotion of health benefits, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits by Shahidi F1, Ambigaipalan P. (PubMed)

#Ginger Induces Airway Smooth Muscle Relaxation to Decrease the Symptoms of #Asthma, Researchers Say

Kyle J. Norton

Scientists may have found a pungent spice for the treatment of airway hyperresponsiveness in asthmatic patients, according to the studies.

Airway hyperresponsiveness is a hallmark of asthma and chronic obstructive pulmonary disease caused by the exaggerated response of the airways to nonspecific stimuli.

Asthma is a respiratory disease associated caused by spasms in the bronchi of the lungs, leading to symptoms of difficulty in breathing. In other words, asthma is a disease as the result of an allergic reaction or other forms of hypersensitivity.

Asthma attacks can be dangerous, if not treated immediately. In an asthma attack, the airways become swollen and inflamed, leading to the overproduction of mucus, which causes the narrowing of the airway.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), 1 in the US, or more than 26 million people have asthma, with 8.3 percent of adults and 8.3 percent of children.

The exact cause of asthma is not known. But exposure to various irritants and substances that trigger allergies (allergens), including airborne substances, such as pollen, dust mites, mold spores, and pet dander are the most common prevalent risk factors.

Some researchers suggested that widespread obesity may be correlated to the rise of asthmatic cases over the past few decades.

Dr. Sveta Mohanan and colleagues in examing the pathophysiology and implications of obesity and asthma in primary care centers wrote, "Mainstream clinical practice has yet to adopt aggressive management of obesity as a modifiable risk factor in asthma care, as is the case with a risk factor like tobacco or allergen exposure".

And, "Our review suggests that evidence of chronic inflammatory response linking obesity and asthma indicates a need to address obesity during asthma management, possibly using patient-centered approaches such as shared decision making".

The findings strongly indicated a link between obesity and the risk of asthma.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of respiratory infection with no side effects evaluated the ginger activity on airway smooth muscle relaxation and calcium regulation.

In isolated human ASM, researchers found that ginger caused significant and rapid relaxation.

In both guinea pig and human tracheas, injection of [6]-gingerol, [8]-gingerol, and [6]-shogaol induced rapid relaxation of precontracted ASM (100–300 μM) compared to [10]-gingerol failure in the induction of relaxation.

In human ASM cells, exposure to [6]-gingerol, [8]-gingerol, and [6]-shogaol, blunted subsequent Ca2+ responses to bradykinin (10 μM) and S-(−)-Bay K 8644 (10 μM) associated with the reuptake in airway smooth muscle compared to no response of the [10]-gingerol at a concentration of 100 μM.

Furthermore, in A/J mice, the nebulization of [8]-gingerol (100 μM), 15 minutes before methacholine challenge, significantly attenuated airway resistance, compared with vehicle.

These results suggested that not all compounds from ginger experts have a respiratory protective effect through inducing airway smooth muscle relaxation, thus decreasing the symptoms of asthma.

Dr. Elizabeth A. Townsend, the lead scientist said, "These novel data show that ginger and its isolated active components, [6]-gingerol, [8]-gingerol, and [6]-shogaol, relax ASM, and [8]-gingerol attenuates airway hyperresponsiveness, in part by altering [Ca2+] I regulation".

In order to reveal more information about ginger relaxed airway smooth muscle (ASM) activity, researchers examined the 6-gingerol, 8-gingerol, or 6-shogaol bioactive compounds found in ginger potentiate β-agonist-induced ASM relaxation.


In human ASM, the airway issues were relaxed dose-dependently with β-agonist, isoproterenol, in the presence of vehicles, 6-gingerol, 8-gingerol, or 6-shogaol (100 μM).


Significant potentiation of isoproterenol-induced relaxation was observed with each of the ginger constituents. 6-Shogaol showed the largest shift in isoproterenol half-maximal effective concentration.


6-Gingerol, 8-gingerol, or 6-shogaol significantly inhibited PDE4D-involved smooth muscle contractility, whereas 8-gingerol and 6-shogaol also inhibited phospholipase C β activity also involved constriction of smooth muscle.

The findings strongly suggested that Isolated components of ginger potentiate βagonist-induced relaxation in human ASM.

Taken together, ginger processed a number of bioactive compounds that may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of asthmatic symptoms through attenuating air hyperresponsiveness.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Effects of Ginger and Its Constituents on Airway Smooth Muscle Relaxation and Calcium Regulation by Elizabeth A. Townsend,1 Matthew E. Siviski,1 Yi Zhang,1 Carrie Xu,1 Bhupinder Hoonjan,2 and Charles W. Emala. (PMC)
(2) Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins by Townsend EA1, Zhang Y, Xu C, Wakita R, Emala CW. (PubMed)
(3) Obesity and asthma: Pathophysiology and implications for diagnosis and management in primary care. by Sveta Mohanan, Hazel Tapp, Andrew McWilliams, and Michael Dulin. (PubMed)

Herbal #Cleaver Extract Inhibits #Resistant-#LaryngealCancer in Vitro, According to Studies

Kyle J. Norton

The larynx is also known as the voice box, located between the pharynx and the trachea. Its function is to ensure the airways open when we breathe and talk and closed when we swallow to ensure no food gets into the trachea.

Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.

The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, are susceptible to the onset of the disease while others do not.

However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection, and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.

Genetic mutation inherited from the parents, such as TP53, GSTM3, and NAT2, and long-term use of some medication, such as immune-suppressive drugs to fight off infections such as HIV or AIDs is considered the prevalent risk factor for the disease development.


The most common symptoms of the larynx (Voice Box) cancer include
* Hoarseness or other voice changes
Due to malignant cells have invaded the vocal cords.

* A cough that doesn't go away or stridor
Due to blocking of the airway.

* Breathing difficulties
The tumor has grown large enough to block off the airway.

* Ear pain
The tumor has pressed onto the nerve.

*A lump or mass in the neck or throat
Cancer has invaded the nearby lymph nodes in the neck and throat.

* Coughing up of blood
Breaking off of some malignant cells.

Cleaver is a herbaceous annual plant, genus Galium, belongings to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as a mild diuretic and blood and lymphatic cleanser to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stones, etc.

In finding a potential compound for the treatment of cancer, researchers investigated a Galium verum decoction in chemosensitive (Hep-2 and HLaC79) and chemoresistant, P-glycoprotein-overexpressing (Hep2-Tax, HLaC79-Tax) laryngeal carcinoma cell lines.

According to the results from the detailed spheroid-based 3D invasion analysis of Hep2 and Hep2-Tax in semisolid collagen gels and on different extracellular matrix coatings, Galium decoction proved to be even more pronounced in the more aggressively invading chemoresistant Hep2-Tax cell line compared to the administration of Galium aqueous extract.

Furthermore, the application of decoction also inhibited the expression of the enzyme gelatinolytic activity produced by the MMP-2 in three of the four cell lines without affecting the angiogenesis in the tested cell lines.

Interestingly, Galium decoction demonstrated an anti-HLaC79 and Hep2, Hep2-Tax, and HLaC79-Taxactivity with no influencing unique pathway activation.

Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".


Taken together, herbal cleaver may be considered as an anti-resistant laryngeal cancer remedy, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Galium verum aqueous extract on growth, motility, and gene expression in drug-sensitive and -resistant laryngeal carcinoma cell lines by Schmidt M1, Scholz CJ2, Gavril GL3, Otto C1, Polednik C1, Roller J1, Hagen R. (PubMed)

#Fennel Powder #Extract, and Oil Inhibit Serum Nitric Oxide (NO) and Kidney #Malondialdehyde (MDA)Induced Oxidativestress through Its Antioxidant Activity

Kyle J. Nortn

Fennel may have a potential and positive effect of eliminating excess water and toxin from our body, some scientists suggested.

Diuresis is a medicine with a function to stimulate increased production of urine.

Detoxification is a process of eliminated toxin accumulation from our bodies. In some cases, the function may only target some specific organs, such as kidneys, liver,..... and lungs.

According to traditional medicine, detoxification is a necessary process to enhance and optimize the functions of our body by cleansing away substances that may reduce or cause harm to our body organs and tissue.

According to the Tao of Wellness in the address of the importance of detoxification of Traditional Chinese Medicine wrote, " Our body is automatically programmed to cleanse itself daily. However, with our fast-paced modern lifestyle and exposure to an increasing number of harmful and toxic substances, our body’s natural cleansing ability has become overworked and compromised" and "Many signs and symptoms attributed to stress are now being linked to exposure from harmful substances such as PCBs, pesticides, herbicides, antibiotics, growth hormones, and mercury in food and liquids as well as dioxins and formaldehyde in the air".

Truly, harmful and toxic substances not removed from our body may have substantially negative implications to cause many serious illnesses, such as cancer, neurodegenerative diseases,..... and reproductive ailments.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb or food has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and depressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...


In an animal model, according to John Wiley & Sons, Ltd. in the evaluation of the re-toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, researchers found that application of the extract exerts a significant activity in flushing out of excess water and toxin from the body through increased kidney function in secretion of fluids.

The result of these properties was observed by an increase in urine flow and urinary sodium excretion.

The efficacy in the cleansing body was also found linearly in dose dependent manner.

Continuously, in further examine the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on the standard diet all over the period of the experiment. and the other groups were administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract, and oil for 45 days, at the end of the study, researchers found that

* Injected gentamicin group served as control and exhibited strong nephrotoxicity manifested by increasing levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialde(MDA) however, this group of rats also exerted a significant decrease in weight gain.

Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by an imbalance of the ratio of ROS and antioxidants in the host.

* Gentamicin groups treated with fennel powder, extract, and oil demonstrated an improve the levels of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes, serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.

These results addressed the important antioxidant effect of fennel extracts.

Furthermore, the applications not only inhibited the levels of free radicals and their' chain-reactive activities but also stimulated the production of antioxidants found in the host tissue.

* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with the normal group and other treatment groups.

Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and confounders said, "Fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats".

Clearly, fennel oil exhibited the greatest effect in stimulating kidney function to detox the body toxins through increased secretion of urine compared to other experimental groups.

The results of this study clearly indicate that fennel powder, extract, and oil are potent antioxidants that ameliorate the levels of gentamicin-induced nephrotoxicity in rats.

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium, and potassium excretion in compared to no effect of Marrubium treated group.

Additionally, in comparison to Marrubium extract reduced hypertension through inhibited contractile responses, fennel restored normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.

Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.

Taken together, fennel and its extracts may be considered a kidney-detoxed functional food in getting rid of body toxins through its diuretic activities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin, and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N(PubMed)

#Herbal Burdock Inhibits Various Pathological and Biochemical Parameters Associated with the Onset of #LiverDiseases

Kyle J. Norton

Herbal Burdock may process a liver protective activity against the onset of liver disease, according to the studies.

The liver is a large organ that processes the function in detoxifying various metabolites, synthesizing proteins, and producing bile for digestion.

Liver diseases are medical conditions of liver damage, leading to reduced function of the liver.

There are many risk factors that cause liver diseases, including genetic preposition, viral infections and long-term use of medication and excessive alcohol drinking.

Liver diseases in most case progress slowly. However, over time the damage can lead to cirrhosis, the main cause of liver failure, and a life-threatening condition.

According to the statistic, in the US, cirrhosis and other chronic liver diseases are common disease-related causes of death. Approximately 31,000 people in the U.S. die each year from cirrhosis.

Sadly, approximately, 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus.

If you are experiencing symptoms of jaundice, persistent abdominal pain, and swelling, dark urine color, pale stool color, or bloody or tar-colored stool, please check with your doctor to rule out the possibility of liver diseases.

The most common cause of liver disease in the third world is hepatitis viral infection, it may be a result of drinking contaminated water and food and lack of clean water.

However, in the Western world, obesity is the major cause of nonalcoholic liver disease. Dr. Sandra Milić, the lead scientist in the concern of non-alcoholic liver disease in obese wrote,
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2."

These results clearly suggested if you are obese you are at 80% most likely to be infected by non-alcoholic liver disease.

Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and blood purifying agent and to treat wounds and infections stomach ulcers, and other digestive problems.

In finding a natural remedy for the treatment of liver diseases, researchers at the Taipei Medical University examined the Arctium lappa Linne (burdock)hepatoprotective effects.

The experiment included a group of rats (n = 10) fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment).

Control group rats were given a liquid basal diet that did not contain absolute ethanol.

Before administrating of herbal Burdock, the ethanol group and the groups receiving ethanol were supplemented with CCl(4). showed significant damage to the liver.

However, treated rat groups with a dose of 300 mg/kg A. lappa administered orally 3 times per day in both the 1-day and 7-day displayed significantly improved various pathological and biochemical parameters which were worsened by ethanol plus CCl(4)-induced liver damage, including decreased levels of serum triglyceride and lipid peroxidation and serum transaminase levels.

Where the elevated levels of serum transaminase are an indication of liver damage.
The finding clearly suggested that hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.

Dr. Lin SC, the lead author wrote in the final report, "The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to another unknown protective mechanism(s)".

Moreover, in male ICR mice injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) to induce liver damage, researchers found that injection of A. lappa significantly suppresses the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) elevations induced by CCl4 or acetaminophen in a dose-dependent manner.

Furthermore, A. lappa also alleviated the severity of liver damage based on histopathological observations.

Where the elevation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is the indication of liver damage.

The efficacy of A. lappa in the in-depth analysis assays was found to attribute to the antioxidant activity in inhibiting the expression of free radicals induced by CCl4 or acetaminophen


A. lappa also was found to decrease the oxidative stress marker, malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice.

Dr. Lin SC the lead scientist after taking into account co and confounders said, "A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen".

Taken altogether, herbal Burdock may be considered a natural remedy for the prevention and treatment of liver disease without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride by Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY. (PubMed)
(2) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage by Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY. (PubMed)
(3) Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations by Sandra Milić, Davorka Lulić, and Davor Štimac. (PubMed)

#Hydrophobic/Hydrophilic Interactions of Ligands isolated from Ginger Inhinit Parameters Associated with the onset of Cognitive Impairment, Scientists Say

Kyle J. Norton

Ginger may be the next pharmaceutical target to extract a single-ingredient medicine for the treatment of Alzheimer's disease, some scientists found.

Alzheimer's disease is a common neurodegenerative disease in the elderly characterized by slowly destroying memory and thinking skills and, eventually, the ability to carry out daily tasks.

According to the Centers for Disease Control and Prevention (CDC), Alzheimer’s disease falls sixth on the list of leading causes of death in the United States.

The average time from diagnosis to death was about four years.

Alzheimer's disease is also increased with an increase in age. In a total of 2,566 people, ages 65 and older under the test of dementia, 559 participants without dementia at the start of the study developed Alzheimer’s disease.

The most common causes of Alzheimer's disease are a combination of genetic, lifestyle, and environmental factors.

However, aging is one most risk factors associated with the onset of the disease in the elderly. Statistics show the number of people with the disease doubles every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease.

Some researchers suggested that the increase in age and risk of Alzheimer's disease can be attributed to the shrinking of certain parts of the brain, and long-term low-grade inflammation, neuron damage induced by oxidative stress due to overexpression of free radicals.

Dr. Tuppo EE, the lead author of the neuro team at the Western University of Health Sciences said, "There is increasing evidence that free radical-induced oxidative damage may play a role in the pathogenesis of Alzheimer's disease. Free radicals are reactive oxygen compounds that may attack and damage lipids, proteins, and DNA".

And, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants".


These results clearly suggested that people who follow a healthy diet with high antioxidants such as fruits and vegetables, whole grains, and fewer red meat and processed foods may have a substantially lower risk of Alzheimer's disease.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In finding the natural ingredient and whole food with a potential effect on patients with Alzheimer's disease, researchers looked into Ginger (Zingiber officinale), a common dietary adjunct that not contributes to the taste and flavor of foods, but also contains a number of potentially bioactive phytochemicals having valuable medicinal properties.

The differentiation of the binding interactions between active ginger components and various anti-Alzheimer drug targets, researchers suggested the approach could be a promising computational tool to aid the optimization of lead compounds obtained from ginger.

The hydrophobic/hydrophilic interactions of ligands isolated from ginger showed to target acetylcholinesterase, the functioning neurotransmitters, and receptors c-Jun N-terminal kinase which plays an important role in the onset of cognitive impairment.


Additionally, researchers found that all isolated compounds is satisfied Lipinski's rule of five, making them potentially promising drug candidates for the treatment of Alzheimer's disease.


Where Lipinski's rule of five is simply the rule of five (RO5) is a rule to determine if a chemical compound with a certain pharmacological or biological activity has chemical properties.


Moreover, in the in-depth investigation of the possible mechanisms of action of these compounds against AD, scientists compared 4 bioactive compounds isolated from ginger to inhibitors of human acetylcholinesterase (HssAChE), the HssAChE inhibitor and commercial drug in use against the AD, donepezil (DNP).

Unsurprisingly, two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diycl diacetate, are considered promising new HssAChE inhibitors that could be as effective as DNP.

Based on these results, researchers said, "the binding of the studied compounds in the different binding pockets inside HssAChE and established the preferred interactions to be favored in the design of new and more efficient inhibitors".


Taken together, ginger processed abundant bioactive compounds that act as acetylcholinesterase (HssAChE) inhibitors may be used as a functional food for the prevention and treatment of Alzheimer's disease without inducing any side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation by Azam F1, Amer AM2, Abulifa AR2, Elzwawi MM2. (PubMed)
(2) A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease by Cuya T1, Baptista L2, Celmar Costa França T. (PubMed)
(3) Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1-42 plaque injected mice by Huh E 1, Lim S , Kim HG , Ha SK , Park HY , Huh Y , Oh MS. (PubMed)

#Healthyfood #FermentedOnionExtract Processes Anti-Hyperlipidemic Activity, Researchers Say

Kyle J. Norton

Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.

Cholesterol produced by the liver plays an essential role in a moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls, and aiding the digestive system in absorbing nutrients and fluids.

There are 2 types of blood cholesterol
* The high-density lipoprotein also known as good cholesterol processes a function to return cholesterol to the liver.

* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in a moderate amount.


In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol to remain in the bloodstream, leading to hyperlipidemia.

The healthy ratio of total blood cholesterol ("bad"/ "good") is any number that is less than 4.

Patients with hyperlipidemia are asymptomatic. However, over time hyperlipidemia can cause plaque to accumulate on the arterial wall, which causes atherosclerosis, a leading cause of heart disease and stroke.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.

Believe it or not, hyperlipidemia, a life-long condition is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a potential and natural compound for the prevention and treatment of hyperlipidemia, researchers examined the antihyperlipidemic and antioxidative potentials of onion (Allium cepa L.) extract fermented with a novel Lactobacillus case HD-010.

Onion oral administration on ApoE-deficient mice, compared to bezafibrate (10 mg/kg, bw/day) as a positive control, showed a significant reduction of the levels of low-density lipoprotein (LDL), triglyceride (TG), and cholesterol.

Also, compared to the positive control, the onion group displayed increased levels of high-density lipoprotein (HDL).


Furthermore, the levels of HMG-CoA reductase associated with the production of good cholesterol was increased by 20% in the fermented onion-treated group at 100 mg/kg.


Moreover, Cholesteryl Ester Transfer Protein (CETP) enzyme is associated with moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. LowerCETP levels promote HDL formation was inhibited by injection of onion compared to the control group.

Based on the findings, researchers said, "These results suggest that fermented onion has a preventive/therapeutic effect on hyperlipidemic disease. It might have the potential to be developed as a functional food".

In order to reveal more about information about onion anti-hyperlipidemic activity, researchers evaluated the effects of raw red onion consumption on metabolic features in overweight and obese women with polycystic ovary syndrome.

The randomized controlled clinical trial included a total of 54) patients randomly allocated to the intervention group as 'high-onion' (raw red onions: 2 × 40-50 g/day if overweight and 2 × 50-60 g/day if obese) or to the control group as 'low-onion' (raw red onions: 2 × 10-15 g/day) along with limited liliaceous vegetables for 8 weeks.

According to the tested analysis, onion administration significantly decreased the levels of total cholesterol in the high-onion group compared to the low-onion group.

Particularly, levels of low-density lipoprotein cholesterol decreased significantly in the high-onion group, compared to the low-onion group after treatment.

However, levels of triglycerides, high-density lipoprotein cholesterol, and lipoprotein did not differ significantly after 8-week onion treatment.

These results strongly suggested that raw red onion consumption is effective in lower cholesterol in women with polycystic ovary syndrome.

Taken altogether, onion may be considered a remedy for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: a randomized controlled clinical trial by Ebrahimi-Mamaghani M1, Saghafi-Asl M, Pirouzpanah S, Asghari-Jafarabadi M. (PubMed)
(2)Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)