Kyle J. Norton
The larynx is also known as the voice box, located between the pharynx and the trachea. Its function is to ensure the airways open when we breathe and talk and closed when we swallow to ensure no food gets into the trachea.
Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.
The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, are susceptible to the onset of the disease while others do not.
However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection, and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.
Genetic mutation inherited from the parents, such as TP53, GSTM3, and NAT2, and long-term use of some medication, such as immune-suppressive drugs to fight off infections such as HIV or AIDs is considered the prevalent risk factor for the disease development.
The most common symptoms of the larynx (Voice Box) cancer include
* Hoarseness or other voice changes
Due to malignant cells have invaded the vocal cords.
* A cough that doesn't go away or stridor
Due to blocking of the airway.
* Breathing difficulties
The tumor has grown large enough to block off the airway.
* Ear pain
The tumor has pressed onto the nerve.
*A lump or mass in the neck or throat
Cancer has invaded the nearby lymph nodes in the neck and throat.
* Coughing up of blood
Breaking off of some malignant cells.
Cleaver is a herbaceous annual plant, genus Galium, belongings to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as a mild diuretic and blood and lymphatic cleanser to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stones, etc.
In finding a potential compound for the treatment of cancer, researchers investigated a Galium verum decoction in chemosensitive (Hep-2 and HLaC79) and chemoresistant, P-glycoprotein-overexpressing (Hep2-Tax, HLaC79-Tax) laryngeal carcinoma cell lines.
According to the results from the detailed spheroid-based 3D invasion analysis of Hep2 and Hep2-Tax in semisolid collagen gels and on different extracellular matrix coatings, Galium decoction proved to be even more pronounced in the more aggressively invading chemoresistant Hep2-Tax cell line compared to the administration of Galium aqueous extract.
Furthermore, the application of decoction also inhibited the expression of the enzyme gelatinolytic activity produced by the MMP-2 in three of the four cell lines without affecting the angiogenesis in the tested cell lines.
Interestingly, Galium decoction demonstrated an anti-HLaC79 and Hep2, Hep2-Tax, and HLaC79-Taxactivity with no influencing unique pathway activation.
Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".
Taken together, herbal cleaver may be considered as an anti-resistant laryngeal cancer remedy, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Galium verum aqueous extract on growth, motility, and gene expression in drug-sensitive and -resistant laryngeal carcinoma cell lines by Schmidt M1, Scholz CJ2, Gavril GL3, Otto C1, Polednik C1, Roller J1, Hagen R. (PubMed)
Saturday, 5 August 2023
#Fennel Powder #Extract, and Oil Inhibit Serum Nitric Oxide (NO) and Kidney #Malondialdehyde (MDA)Induced Oxidativestress through Its Antioxidant Activity
Kyle J. Nortn
Fennel may have a potential and positive effect of eliminating excess water and toxin from our body, some scientists suggested.
Diuresis is a medicine with a function to stimulate increased production of urine.
Detoxification is a process of eliminated toxin accumulation from our bodies. In some cases, the function may only target some specific organs, such as kidneys, liver,..... and lungs.
According to traditional medicine, detoxification is a necessary process to enhance and optimize the functions of our body by cleansing away substances that may reduce or cause harm to our body organs and tissue.
According to the Tao of Wellness in the address of the importance of detoxification of Traditional Chinese Medicine wrote, " Our body is automatically programmed to cleanse itself daily. However, with our fast-paced modern lifestyle and exposure to an increasing number of harmful and toxic substances, our body’s natural cleansing ability has become overworked and compromised" and "Many signs and symptoms attributed to stress are now being linked to exposure from harmful substances such as PCBs, pesticides, herbicides, antibiotics, growth hormones, and mercury in food and liquids as well as dioxins and formaldehyde in the air".
Truly, harmful and toxic substances not removed from our body may have substantially negative implications to cause many serious illnesses, such as cancer, neurodegenerative diseases,..... and reproductive ailments.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb or food has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and depressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In an animal model, according to John Wiley & Sons, Ltd. in the evaluation of the re-toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, researchers found that application of the extract exerts a significant activity in flushing out of excess water and toxin from the body through increased kidney function in secretion of fluids.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in the cleansing body was also found linearly in dose dependent manner.
Continuously, in further examine the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on the standard diet all over the period of the experiment. and the other groups were administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract, and oil for 45 days, at the end of the study, researchers found that
* Injected gentamicin group served as control and exhibited strong nephrotoxicity manifested by increasing levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialde(MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by an imbalance of the ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract, and oil demonstrated an improve the levels of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes, serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts.
Furthermore, the applications not only inhibited the levels of free radicals and their' chain-reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with the normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and confounders said, "Fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulating kidney function to detox the body toxins through increased secretion of urine compared to other experimental groups.
The results of this study clearly indicate that fennel powder, extract, and oil are potent antioxidants that ameliorate the levels of gentamicin-induced nephrotoxicity in rats.
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium, and potassium excretion in compared to no effect of Marrubium treated group.
Additionally, in comparison to Marrubium extract reduced hypertension through inhibited contractile responses, fennel restored normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered a kidney-detoxed functional food in getting rid of body toxins through its diuretic activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin, and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N(PubMed)
Fennel may have a potential and positive effect of eliminating excess water and toxin from our body, some scientists suggested.
Diuresis is a medicine with a function to stimulate increased production of urine.
Detoxification is a process of eliminated toxin accumulation from our bodies. In some cases, the function may only target some specific organs, such as kidneys, liver,..... and lungs.
According to traditional medicine, detoxification is a necessary process to enhance and optimize the functions of our body by cleansing away substances that may reduce or cause harm to our body organs and tissue.
According to the Tao of Wellness in the address of the importance of detoxification of Traditional Chinese Medicine wrote, " Our body is automatically programmed to cleanse itself daily. However, with our fast-paced modern lifestyle and exposure to an increasing number of harmful and toxic substances, our body’s natural cleansing ability has become overworked and compromised" and "Many signs and symptoms attributed to stress are now being linked to exposure from harmful substances such as PCBs, pesticides, herbicides, antibiotics, growth hormones, and mercury in food and liquids as well as dioxins and formaldehyde in the air".
Truly, harmful and toxic substances not removed from our body may have substantially negative implications to cause many serious illnesses, such as cancer, neurodegenerative diseases,..... and reproductive ailments.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb or food has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and depressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In an animal model, according to John Wiley & Sons, Ltd. in the evaluation of the re-toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, researchers found that application of the extract exerts a significant activity in flushing out of excess water and toxin from the body through increased kidney function in secretion of fluids.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in the cleansing body was also found linearly in dose dependent manner.
Continuously, in further examine the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on the standard diet all over the period of the experiment. and the other groups were administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract, and oil for 45 days, at the end of the study, researchers found that
* Injected gentamicin group served as control and exhibited strong nephrotoxicity manifested by increasing levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialde(MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by an imbalance of the ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract, and oil demonstrated an improve the levels of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes, serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts.
Furthermore, the applications not only inhibited the levels of free radicals and their' chain-reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with the normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and confounders said, "Fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulating kidney function to detox the body toxins through increased secretion of urine compared to other experimental groups.
The results of this study clearly indicate that fennel powder, extract, and oil are potent antioxidants that ameliorate the levels of gentamicin-induced nephrotoxicity in rats.
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium, and potassium excretion in compared to no effect of Marrubium treated group.
Additionally, in comparison to Marrubium extract reduced hypertension through inhibited contractile responses, fennel restored normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered a kidney-detoxed functional food in getting rid of body toxins through its diuretic activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin, and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N(PubMed)
#Herbal Burdock Inhibits Various Pathological and Biochemical Parameters Associated with the Onset of #LiverDiseases
Kyle J. Norton
Herbal Burdock may process a liver protective activity against the onset of liver disease, according to the studies.
The liver is a large organ that processes the function in detoxifying various metabolites, synthesizing proteins, and producing bile for digestion.
Liver diseases are medical conditions of liver damage, leading to reduced function of the liver.
There are many risk factors that cause liver diseases, including genetic preposition, viral infections and long-term use of medication and excessive alcohol drinking.
Liver diseases in most case progress slowly. However, over time the damage can lead to cirrhosis, the main cause of liver failure, and a life-threatening condition.
According to the statistic, in the US, cirrhosis and other chronic liver diseases are common disease-related causes of death. Approximately 31,000 people in the U.S. die each year from cirrhosis.
Sadly, approximately, 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus.
If you are experiencing symptoms of jaundice, persistent abdominal pain, and swelling, dark urine color, pale stool color, or bloody or tar-colored stool, please check with your doctor to rule out the possibility of liver diseases.
The most common cause of liver disease in the third world is hepatitis viral infection, it may be a result of drinking contaminated water and food and lack of clean water.
However, in the Western world, obesity is the major cause of nonalcoholic liver disease. Dr. Sandra Milić, the lead scientist in the concern of non-alcoholic liver disease in obese wrote,
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2."
These results clearly suggested if you are obese you are at 80% most likely to be infected by non-alcoholic liver disease.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and blood purifying agent and to treat wounds and infections stomach ulcers, and other digestive problems.
In finding a natural remedy for the treatment of liver diseases, researchers at the Taipei Medical University examined the Arctium lappa Linne (burdock)hepatoprotective effects.
The experiment included a group of rats (n = 10) fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment).
Control group rats were given a liquid basal diet that did not contain absolute ethanol.
Before administrating of herbal Burdock, the ethanol group and the groups receiving ethanol were supplemented with CCl(4). showed significant damage to the liver.
However, treated rat groups with a dose of 300 mg/kg A. lappa administered orally 3 times per day in both the 1-day and 7-day displayed significantly improved various pathological and biochemical parameters which were worsened by ethanol plus CCl(4)-induced liver damage, including decreased levels of serum triglyceride and lipid peroxidation and serum transaminase levels.
Where the elevated levels of serum transaminase are an indication of liver damage.
The finding clearly suggested that hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.
Dr. Lin SC, the lead author wrote in the final report, "The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to another unknown protective mechanism(s)".
Moreover, in male ICR mice injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) to induce liver damage, researchers found that injection of A. lappa significantly suppresses the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) elevations induced by CCl4 or acetaminophen in a dose-dependent manner.
Furthermore, A. lappa also alleviated the severity of liver damage based on histopathological observations.
Where the elevation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is the indication of liver damage.
The efficacy of A. lappa in the in-depth analysis assays was found to attribute to the antioxidant activity in inhibiting the expression of free radicals induced by CCl4 or acetaminophen
A. lappa also was found to decrease the oxidative stress marker, malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice.
Dr. Lin SC the lead scientist after taking into account co and confounders said, "A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen".
Taken altogether, herbal Burdock may be considered a natural remedy for the prevention and treatment of liver disease without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride by Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY. (PubMed)
(2) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage by Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY. (PubMed)
(3) Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations by Sandra Milić, Davorka Lulić, and Davor Štimac. (PubMed)
Herbal Burdock may process a liver protective activity against the onset of liver disease, according to the studies.
The liver is a large organ that processes the function in detoxifying various metabolites, synthesizing proteins, and producing bile for digestion.
Liver diseases are medical conditions of liver damage, leading to reduced function of the liver.
There are many risk factors that cause liver diseases, including genetic preposition, viral infections and long-term use of medication and excessive alcohol drinking.
Liver diseases in most case progress slowly. However, over time the damage can lead to cirrhosis, the main cause of liver failure, and a life-threatening condition.
According to the statistic, in the US, cirrhosis and other chronic liver diseases are common disease-related causes of death. Approximately 31,000 people in the U.S. die each year from cirrhosis.
Sadly, approximately, 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus.
If you are experiencing symptoms of jaundice, persistent abdominal pain, and swelling, dark urine color, pale stool color, or bloody or tar-colored stool, please check with your doctor to rule out the possibility of liver diseases.
The most common cause of liver disease in the third world is hepatitis viral infection, it may be a result of drinking contaminated water and food and lack of clean water.
However, in the Western world, obesity is the major cause of nonalcoholic liver disease. Dr. Sandra Milić, the lead scientist in the concern of non-alcoholic liver disease in obese wrote,
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2."
These results clearly suggested if you are obese you are at 80% most likely to be infected by non-alcoholic liver disease.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and blood purifying agent and to treat wounds and infections stomach ulcers, and other digestive problems.
In finding a natural remedy for the treatment of liver diseases, researchers at the Taipei Medical University examined the Arctium lappa Linne (burdock)hepatoprotective effects.
The experiment included a group of rats (n = 10) fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment).
Control group rats were given a liquid basal diet that did not contain absolute ethanol.
Before administrating of herbal Burdock, the ethanol group and the groups receiving ethanol were supplemented with CCl(4). showed significant damage to the liver.
However, treated rat groups with a dose of 300 mg/kg A. lappa administered orally 3 times per day in both the 1-day and 7-day displayed significantly improved various pathological and biochemical parameters which were worsened by ethanol plus CCl(4)-induced liver damage, including decreased levels of serum triglyceride and lipid peroxidation and serum transaminase levels.
Where the elevated levels of serum transaminase are an indication of liver damage.
The finding clearly suggested that hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.
Dr. Lin SC, the lead author wrote in the final report, "The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to another unknown protective mechanism(s)".
Moreover, in male ICR mice injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) to induce liver damage, researchers found that injection of A. lappa significantly suppresses the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) elevations induced by CCl4 or acetaminophen in a dose-dependent manner.
Furthermore, A. lappa also alleviated the severity of liver damage based on histopathological observations.
Where the elevation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is the indication of liver damage.
The efficacy of A. lappa in the in-depth analysis assays was found to attribute to the antioxidant activity in inhibiting the expression of free radicals induced by CCl4 or acetaminophen
A. lappa also was found to decrease the oxidative stress marker, malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice.
Dr. Lin SC the lead scientist after taking into account co and confounders said, "A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen".
Taken altogether, herbal Burdock may be considered a natural remedy for the prevention and treatment of liver disease without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride by Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY. (PubMed)
(2) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage by Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY. (PubMed)
(3) Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations by Sandra Milić, Davorka Lulić, and Davor Štimac. (PubMed)
#Hydrophobic/Hydrophilic Interactions of Ligands isolated from Ginger Inhinit Parameters Associated with the onset of Cognitive Impairment, Scientists Say
Kyle J. Norton
Ginger may be the next pharmaceutical target to extract a single-ingredient medicine for the treatment of Alzheimer's disease, some scientists found.
Alzheimer's disease is a common neurodegenerative disease in the elderly characterized by slowly destroying memory and thinking skills and, eventually, the ability to carry out daily tasks.
According to the Centers for Disease Control and Prevention (CDC), Alzheimer’s disease falls sixth on the list of leading causes of death in the United States.
The average time from diagnosis to death was about four years.
Alzheimer's disease is also increased with an increase in age. In a total of 2,566 people, ages 65 and older under the test of dementia, 559 participants without dementia at the start of the study developed Alzheimer’s disease.
The most common causes of Alzheimer's disease are a combination of genetic, lifestyle, and environmental factors.
However, aging is one most risk factors associated with the onset of the disease in the elderly. Statistics show the number of people with the disease doubles every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease.
Some researchers suggested that the increase in age and risk of Alzheimer's disease can be attributed to the shrinking of certain parts of the brain, and long-term low-grade inflammation, neuron damage induced by oxidative stress due to overexpression of free radicals.
Dr. Tuppo EE, the lead author of the neuro team at the Western University of Health Sciences said, "There is increasing evidence that free radical-induced oxidative damage may play a role in the pathogenesis of Alzheimer's disease. Free radicals are reactive oxygen compounds that may attack and damage lipids, proteins, and DNA".
And, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants".
These results clearly suggested that people who follow a healthy diet with high antioxidants such as fruits and vegetables, whole grains, and fewer red meat and processed foods may have a substantially lower risk of Alzheimer's disease.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In finding the natural ingredient and whole food with a potential effect on patients with Alzheimer's disease, researchers looked into Ginger (Zingiber officinale), a common dietary adjunct that not contributes to the taste and flavor of foods, but also contains a number of potentially bioactive phytochemicals having valuable medicinal properties.
The differentiation of the binding interactions between active ginger components and various anti-Alzheimer drug targets, researchers suggested the approach could be a promising computational tool to aid the optimization of lead compounds obtained from ginger.
The hydrophobic/hydrophilic interactions of ligands isolated from ginger showed to target acetylcholinesterase, the functioning neurotransmitters, and receptors c-Jun N-terminal kinase which plays an important role in the onset of cognitive impairment.
Additionally, researchers found that all isolated compounds is satisfied Lipinski's rule of five, making them potentially promising drug candidates for the treatment of Alzheimer's disease.
Where Lipinski's rule of five is simply the rule of five (RO5) is a rule to determine if a chemical compound with a certain pharmacological or biological activity has chemical properties.
Moreover, in the in-depth investigation of the possible mechanisms of action of these compounds against AD, scientists compared 4 bioactive compounds isolated from ginger to inhibitors of human acetylcholinesterase (HssAChE), the HssAChE inhibitor and commercial drug in use against the AD, donepezil (DNP).
Unsurprisingly, two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diycl diacetate, are considered promising new HssAChE inhibitors that could be as effective as DNP.
Based on these results, researchers said, "the binding of the studied compounds in the different binding pockets inside HssAChE and established the preferred interactions to be favored in the design of new and more efficient inhibitors".
Taken together, ginger processed abundant bioactive compounds that act as acetylcholinesterase (HssAChE) inhibitors may be used as a functional food for the prevention and treatment of Alzheimer's disease without inducing any side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation by Azam F1, Amer AM2, Abulifa AR2, Elzwawi MM2. (PubMed)
(2) A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease by Cuya T1, Baptista L2, Celmar Costa França T. (PubMed)
(3) Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1-42 plaque injected mice by Huh E 1, Lim S , Kim HG , Ha SK , Park HY , Huh Y , Oh MS. (PubMed)
Ginger may be the next pharmaceutical target to extract a single-ingredient medicine for the treatment of Alzheimer's disease, some scientists found.
Alzheimer's disease is a common neurodegenerative disease in the elderly characterized by slowly destroying memory and thinking skills and, eventually, the ability to carry out daily tasks.
According to the Centers for Disease Control and Prevention (CDC), Alzheimer’s disease falls sixth on the list of leading causes of death in the United States.
The average time from diagnosis to death was about four years.
Alzheimer's disease is also increased with an increase in age. In a total of 2,566 people, ages 65 and older under the test of dementia, 559 participants without dementia at the start of the study developed Alzheimer’s disease.
The most common causes of Alzheimer's disease are a combination of genetic, lifestyle, and environmental factors.
However, aging is one most risk factors associated with the onset of the disease in the elderly. Statistics show the number of people with the disease doubles every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease.
Some researchers suggested that the increase in age and risk of Alzheimer's disease can be attributed to the shrinking of certain parts of the brain, and long-term low-grade inflammation, neuron damage induced by oxidative stress due to overexpression of free radicals.
Dr. Tuppo EE, the lead author of the neuro team at the Western University of Health Sciences said, "There is increasing evidence that free radical-induced oxidative damage may play a role in the pathogenesis of Alzheimer's disease. Free radicals are reactive oxygen compounds that may attack and damage lipids, proteins, and DNA".
And, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants".
These results clearly suggested that people who follow a healthy diet with high antioxidants such as fruits and vegetables, whole grains, and fewer red meat and processed foods may have a substantially lower risk of Alzheimer's disease.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In finding the natural ingredient and whole food with a potential effect on patients with Alzheimer's disease, researchers looked into Ginger (Zingiber officinale), a common dietary adjunct that not contributes to the taste and flavor of foods, but also contains a number of potentially bioactive phytochemicals having valuable medicinal properties.
The differentiation of the binding interactions between active ginger components and various anti-Alzheimer drug targets, researchers suggested the approach could be a promising computational tool to aid the optimization of lead compounds obtained from ginger.
The hydrophobic/hydrophilic interactions of ligands isolated from ginger showed to target acetylcholinesterase, the functioning neurotransmitters, and receptors c-Jun N-terminal kinase which plays an important role in the onset of cognitive impairment.
Additionally, researchers found that all isolated compounds is satisfied Lipinski's rule of five, making them potentially promising drug candidates for the treatment of Alzheimer's disease.
Where Lipinski's rule of five is simply the rule of five (RO5) is a rule to determine if a chemical compound with a certain pharmacological or biological activity has chemical properties.
Moreover, in the in-depth investigation of the possible mechanisms of action of these compounds against AD, scientists compared 4 bioactive compounds isolated from ginger to inhibitors of human acetylcholinesterase (HssAChE), the HssAChE inhibitor and commercial drug in use against the AD, donepezil (DNP).
Unsurprisingly, two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diycl diacetate, are considered promising new HssAChE inhibitors that could be as effective as DNP.
Based on these results, researchers said, "the binding of the studied compounds in the different binding pockets inside HssAChE and established the preferred interactions to be favored in the design of new and more efficient inhibitors".
Taken together, ginger processed abundant bioactive compounds that act as acetylcholinesterase (HssAChE) inhibitors may be used as a functional food for the prevention and treatment of Alzheimer's disease without inducing any side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation by Azam F1, Amer AM2, Abulifa AR2, Elzwawi MM2. (PubMed)
(2) A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease by Cuya T1, Baptista L2, Celmar Costa França T. (PubMed)
(3) Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1-42 plaque injected mice by Huh E 1, Lim S , Kim HG , Ha SK , Park HY , Huh Y , Oh MS. (PubMed)
#Healthyfood #FermentedOnionExtract Processes Anti-Hyperlipidemic Activity, Researchers Say
Kyle J. Norton
Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.
Cholesterol produced by the liver plays an essential role in a moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls, and aiding the digestive system in absorbing nutrients and fluids.
There are 2 types of blood cholesterol
* The high-density lipoprotein also known as good cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in a moderate amount.
In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol to remain in the bloodstream, leading to hyperlipidemia.
The healthy ratio of total blood cholesterol ("bad"/ "good") is any number that is less than 4.
Patients with hyperlipidemia are asymptomatic. However, over time hyperlipidemia can cause plaque to accumulate on the arterial wall, which causes atherosclerosis, a leading cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Believe it or not, hyperlipidemia, a life-long condition is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention and treatment of hyperlipidemia, researchers examined the antihyperlipidemic and antioxidative potentials of onion (Allium cepa L.) extract fermented with a novel Lactobacillus case HD-010.
Onion oral administration on ApoE-deficient mice, compared to bezafibrate (10 mg/kg, bw/day) as a positive control, showed a significant reduction of the levels of low-density lipoprotein (LDL), triglyceride (TG), and cholesterol.
Also, compared to the positive control, the onion group displayed increased levels of high-density lipoprotein (HDL).
Furthermore, the levels of HMG-CoA reductase associated with the production of good cholesterol was increased by 20% in the fermented onion-treated group at 100 mg/kg.
Moreover, Cholesteryl Ester Transfer Protein (CETP) enzyme is associated with moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. LowerCETP levels promote HDL formation was inhibited by injection of onion compared to the control group.
Based on the findings, researchers said, "These results suggest that fermented onion has a preventive/therapeutic effect on hyperlipidemic disease. It might have the potential to be developed as a functional food".
In order to reveal more about information about onion anti-hyperlipidemic activity, researchers evaluated the effects of raw red onion consumption on metabolic features in overweight and obese women with polycystic ovary syndrome.
The randomized controlled clinical trial included a total of 54) patients randomly allocated to the intervention group as 'high-onion' (raw red onions: 2 × 40-50 g/day if overweight and 2 × 50-60 g/day if obese) or to the control group as 'low-onion' (raw red onions: 2 × 10-15 g/day) along with limited liliaceous vegetables for 8 weeks.
According to the tested analysis, onion administration significantly decreased the levels of total cholesterol in the high-onion group compared to the low-onion group.
Particularly, levels of low-density lipoprotein cholesterol decreased significantly in the high-onion group, compared to the low-onion group after treatment.
However, levels of triglycerides, high-density lipoprotein cholesterol, and lipoprotein did not differ significantly after 8-week onion treatment.
These results strongly suggested that raw red onion consumption is effective in lower cholesterol in women with polycystic ovary syndrome.
Taken altogether, onion may be considered a remedy for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: a randomized controlled clinical trial by Ebrahimi-Mamaghani M1, Saghafi-Asl M, Pirouzpanah S, Asghari-Jafarabadi M. (PubMed)
(2)Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.
Cholesterol produced by the liver plays an essential role in a moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls, and aiding the digestive system in absorbing nutrients and fluids.
There are 2 types of blood cholesterol
* The high-density lipoprotein also known as good cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in a moderate amount.
In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol to remain in the bloodstream, leading to hyperlipidemia.
The healthy ratio of total blood cholesterol ("bad"/ "good") is any number that is less than 4.
Patients with hyperlipidemia are asymptomatic. However, over time hyperlipidemia can cause plaque to accumulate on the arterial wall, which causes atherosclerosis, a leading cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Believe it or not, hyperlipidemia, a life-long condition is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention and treatment of hyperlipidemia, researchers examined the antihyperlipidemic and antioxidative potentials of onion (Allium cepa L.) extract fermented with a novel Lactobacillus case HD-010.
Onion oral administration on ApoE-deficient mice, compared to bezafibrate (10 mg/kg, bw/day) as a positive control, showed a significant reduction of the levels of low-density lipoprotein (LDL), triglyceride (TG), and cholesterol.
Also, compared to the positive control, the onion group displayed increased levels of high-density lipoprotein (HDL).
Furthermore, the levels of HMG-CoA reductase associated with the production of good cholesterol was increased by 20% in the fermented onion-treated group at 100 mg/kg.
Moreover, Cholesteryl Ester Transfer Protein (CETP) enzyme is associated with moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. LowerCETP levels promote HDL formation was inhibited by injection of onion compared to the control group.
Based on the findings, researchers said, "These results suggest that fermented onion has a preventive/therapeutic effect on hyperlipidemic disease. It might have the potential to be developed as a functional food".
In order to reveal more about information about onion anti-hyperlipidemic activity, researchers evaluated the effects of raw red onion consumption on metabolic features in overweight and obese women with polycystic ovary syndrome.
The randomized controlled clinical trial included a total of 54) patients randomly allocated to the intervention group as 'high-onion' (raw red onions: 2 × 40-50 g/day if overweight and 2 × 50-60 g/day if obese) or to the control group as 'low-onion' (raw red onions: 2 × 10-15 g/day) along with limited liliaceous vegetables for 8 weeks.
According to the tested analysis, onion administration significantly decreased the levels of total cholesterol in the high-onion group compared to the low-onion group.
Particularly, levels of low-density lipoprotein cholesterol decreased significantly in the high-onion group, compared to the low-onion group after treatment.
However, levels of triglycerides, high-density lipoprotein cholesterol, and lipoprotein did not differ significantly after 8-week onion treatment.
These results strongly suggested that raw red onion consumption is effective in lower cholesterol in women with polycystic ovary syndrome.
Taken altogether, onion may be considered a remedy for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: a randomized controlled clinical trial by Ebrahimi-Mamaghani M1, Saghafi-Asl M, Pirouzpanah S, Asghari-Jafarabadi M. (PubMed)
(2)Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
#Extract Polyphenols from #Eggplant Inhibit Peroxidation of Cerebral and Hepatic Lipids through Their Antioxidant Activity
Kyle J. Norton
Scientists may have found a whole vegetable that processes the function of balancing the ratio of free radicals and antioxidants, some studies suggested.
Free radicals are unstable molecules with an unpaired electron in the outer ring. In order for them to become stable, free radicals always seek other atoms or molecules to bond to leading to a domino's effect that cannot stop until they are either paired or inhibited by antioxidants
The continuation of this domino's effects is known to begin a process called oxidative stress. A prolonged period of overexpression of free radicals can cause oxidative stress, a major cause of some chronic diseases, including diabetes.
Truly, free radicals and oxidants play a dual role as both toxic and beneficial compounds. On the benefit side, according to Wanjek wrote in 2006, "The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders".
Free radicals can promote toxicity to cancer cells, leading to antiproliferative and apoptotic effects without harming the nearby healthy cell if administered with dietary antioxidants or stimulated the production of antioxidants enzymes in the host through healthy food sources.
On the other hand, overexpression of free radicals can be very harmful, Dr. Lien Ai Pham-Huy, the lead author in the study "Free Radicals, Antioxidants in Disease and Health" said, "When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases".
"The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ or externally supplied through foods and/or supplements".
These analyses suggested that a healthy diet and lifestyle play a critical role in reducing the risk of imbalance of the ratio of free radicals and antioxidants by increasing the expression of antioxidants and decreasing the risk of overload of free radicals.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India. The plant has been cultivated in southern and eastern Asia since prehistory.
It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The vegetable chemical compounds include sterols (i.e. typical plant sterols, androstane, pregnant, and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In reaffirming the effects of eggplant-rich source of polyphenol compounds endowed with antioxidant properties, researchers launched an evaluation to compare the antioxidant activity of the extract polyphenols from eggplant entire fruit, pulp, or skin, both fresh and dry and conventional extraction and microwave-assisted extraction (MAE).
In the time exposure 15, 30, 60, and 90 min) and solvent water 100% or ethanol/water, researchers found that 50% dry peeled skin treated with 50% aqueous ethanol, exerted a good antioxidant activity expressed by its capacity to scavenge superoxide anion and to inhibit lipid peroxidation compared to another eggplant extract.
Furthermore, in the evaluation of the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG)(Eggplant) and it is possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential (ΔΨm) isolated from rat liver, researchers showed that
* SAG exhibited potent and concentration-dependent free radical-scavenging activity (IC50/DPPH=275.03±7.8 μg/mL).
* Reductive and iron chelation abilities also increase with an increase in SAG concentration.
* SAG also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative assault.
The effect of eggplant in reducing the expression of free radicals was attributed to the presence of major bioactive compounds, including gallic acid [(17.54±0.04) mg/g], chlorogenic acid (21.90±0.02 mg/g), caffeic acid (16.64±0.01 mg/g), rutin [(14.71±0.03) mg/g] and quercetin [(7.39±0.05) mg/g].
Dr. Elekofehinti OO, the lead scientist said, "SAG extract is a potential source of natural antioxidants that may be used not only in the pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress".
Taken together, there is no doubt that eggplant processes a powerful antioxidants activity in the prevention of overexpression of free radicals in the initiation of oxidative stress and combined with a primary theory for the treatment of oxidative stress-related diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts by Salerno L, Modica MN, Pittalà V, Romeo G, Siracusa MA, Di Giacomo C, Sorrenti V, Acquaviva R.(PubMed)
(2) African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca(2+)-induced mitochondrial swelling by Elekofehinti OO1, Kamdem JP, Bolingon AA, Athayde ML, Lopes SR, Waczuk EP, Kade IJ, Adanlawo IG, Rocha JB. (PubMed)
Scientists may have found a whole vegetable that processes the function of balancing the ratio of free radicals and antioxidants, some studies suggested.
Free radicals are unstable molecules with an unpaired electron in the outer ring. In order for them to become stable, free radicals always seek other atoms or molecules to bond to leading to a domino's effect that cannot stop until they are either paired or inhibited by antioxidants
The continuation of this domino's effects is known to begin a process called oxidative stress. A prolonged period of overexpression of free radicals can cause oxidative stress, a major cause of some chronic diseases, including diabetes.
Truly, free radicals and oxidants play a dual role as both toxic and beneficial compounds. On the benefit side, according to Wanjek wrote in 2006, "The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders".
Free radicals can promote toxicity to cancer cells, leading to antiproliferative and apoptotic effects without harming the nearby healthy cell if administered with dietary antioxidants or stimulated the production of antioxidants enzymes in the host through healthy food sources.
On the other hand, overexpression of free radicals can be very harmful, Dr. Lien Ai Pham-Huy, the lead author in the study "Free Radicals, Antioxidants in Disease and Health" said, "When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases".
"The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ or externally supplied through foods and/or supplements".
These analyses suggested that a healthy diet and lifestyle play a critical role in reducing the risk of imbalance of the ratio of free radicals and antioxidants by increasing the expression of antioxidants and decreasing the risk of overload of free radicals.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India. The plant has been cultivated in southern and eastern Asia since prehistory.
It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The vegetable chemical compounds include sterols (i.e. typical plant sterols, androstane, pregnant, and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In reaffirming the effects of eggplant-rich source of polyphenol compounds endowed with antioxidant properties, researchers launched an evaluation to compare the antioxidant activity of the extract polyphenols from eggplant entire fruit, pulp, or skin, both fresh and dry and conventional extraction and microwave-assisted extraction (MAE).
In the time exposure 15, 30, 60, and 90 min) and solvent water 100% or ethanol/water, researchers found that 50% dry peeled skin treated with 50% aqueous ethanol, exerted a good antioxidant activity expressed by its capacity to scavenge superoxide anion and to inhibit lipid peroxidation compared to another eggplant extract.
Furthermore, in the evaluation of the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG)(Eggplant) and it is possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential (ΔΨm) isolated from rat liver, researchers showed that
* SAG exhibited potent and concentration-dependent free radical-scavenging activity (IC50/DPPH=275.03±7.8 μg/mL).
* Reductive and iron chelation abilities also increase with an increase in SAG concentration.
* SAG also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative assault.
The effect of eggplant in reducing the expression of free radicals was attributed to the presence of major bioactive compounds, including gallic acid [(17.54±0.04) mg/g], chlorogenic acid (21.90±0.02 mg/g), caffeic acid (16.64±0.01 mg/g), rutin [(14.71±0.03) mg/g] and quercetin [(7.39±0.05) mg/g].
Dr. Elekofehinti OO, the lead scientist said, "SAG extract is a potential source of natural antioxidants that may be used not only in the pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress".
Taken together, there is no doubt that eggplant processes a powerful antioxidants activity in the prevention of overexpression of free radicals in the initiation of oxidative stress and combined with a primary theory for the treatment of oxidative stress-related diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts by Salerno L, Modica MN, Pittalà V, Romeo G, Siracusa MA, Di Giacomo C, Sorrenti V, Acquaviva R.(PubMed)
(2) African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca(2+)-induced mitochondrial swelling by Elekofehinti OO1, Kamdem JP, Bolingon AA, Athayde ML, Lopes SR, Waczuk EP, Kade IJ, Adanlawo IG, Rocha JB. (PubMed)
#Herbal #Ashwagandha #Extract Processes Depressant-Like Activity, According to Studies
Kyle J. Norton
Chronic stress is the response to emotional pressure in demanding situations over a period of time, leading to the release of the hormone cortisol and adrenaline.
The most common factors associated with stress incidence include psychological pressures, such as work deadlines, and exams, high-pressure jobs, and financial difficulties.
Overtime unresolved chronic stress can cause a wide range of symptoms and increase the risk of depression.
Depression is a common and serious psychological illness, affects the physical and mental functions of patients, including the patients feeling, thinking, and acting.
Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.
There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief, or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.
The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, and loss of interest in friends, family, favorite activities, and sex.
In severe cases, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering, and thoughts of harming or themselves.
According to the statistics provided by the Anxiety and Depression of Association of American, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.
Conventionally, selective serotonin reuptake inhibitors (SSRIs) are the primary medication for the treatment of depression due to their relatively lower side effects compared to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants, and monoamine oxidase inhibitors (MAOIs).
In finding a potent compound for the treatment of depression, researchers examined the effects of extracts of Withania somnifera (WSE)as an adjunctive treatment in patients with schizophrenia experiencing an exacerbation of positive symptoms.
The randomized, placebo-controlled, double-blind 12-week study included patients with schizophrenia who received 1,000 mg of standardized WSE. conducted by the University of Pittsburgh Medical Center.
Based on the 66 patients with depression symptoms, the Positive and Negative Syndrome Scale. showed the WSE exerted medium effect sizes of 0.683 (95% confidence interval [CI], 0.16 to 1.21) compared to placebo.
More importantly, the adverse effects were mild and transient, according to patient reports.
Collectively, researchers wrote after taking other factors into account, "WSE may hold promise in the treatment of depression... symptoms in schizophrenia".
Taken together, Ashwagandha may be considered a functional herb for the prevention of depressive symptoms in patients with schizophrenia, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial by Gannon JM1, Brar J, Rai A, Chengappa KNR. (PubMed)
Chronic stress is the response to emotional pressure in demanding situations over a period of time, leading to the release of the hormone cortisol and adrenaline.
The most common factors associated with stress incidence include psychological pressures, such as work deadlines, and exams, high-pressure jobs, and financial difficulties.
Overtime unresolved chronic stress can cause a wide range of symptoms and increase the risk of depression.
Depression is a common and serious psychological illness, affects the physical and mental functions of patients, including the patients feeling, thinking, and acting.
Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.
There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief, or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.
The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, and loss of interest in friends, family, favorite activities, and sex.
In severe cases, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering, and thoughts of harming or themselves.
According to the statistics provided by the Anxiety and Depression of Association of American, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.
Conventionally, selective serotonin reuptake inhibitors (SSRIs) are the primary medication for the treatment of depression due to their relatively lower side effects compared to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants, and monoamine oxidase inhibitors (MAOIs).
In finding a potent compound for the treatment of depression, researchers examined the effects of extracts of Withania somnifera (WSE)as an adjunctive treatment in patients with schizophrenia experiencing an exacerbation of positive symptoms.
The randomized, placebo-controlled, double-blind 12-week study included patients with schizophrenia who received 1,000 mg of standardized WSE. conducted by the University of Pittsburgh Medical Center.
Based on the 66 patients with depression symptoms, the Positive and Negative Syndrome Scale. showed the WSE exerted medium effect sizes of 0.683 (95% confidence interval [CI], 0.16 to 1.21) compared to placebo.
More importantly, the adverse effects were mild and transient, according to patient reports.
Collectively, researchers wrote after taking other factors into account, "WSE may hold promise in the treatment of depression... symptoms in schizophrenia".
Taken together, Ashwagandha may be considered a functional herb for the prevention of depressive symptoms in patients with schizophrenia, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial by Gannon JM1, Brar J, Rai A, Chengappa KNR. (PubMed)
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