Kyle J. Norton
Herbal Butterbur may be the potential target to extract a single ingredient for the treatment of oxidative stress, some scientists suggested.
Oxidative stress is either caused by overexpression of free radicals compared to levels of antioxidants or suppression of the levels of antioxidant enzymes in the host body, compared to the expression of free radicals.
The imbalanced ratio of free radical and antioxidant enzymes produced by the host that counter the overexpression of free radicals has been found to facilitate the early onset of a number of chronic ailments, such as cancers.
Free radicals are naturally produced from daily normal essential metabolic processes in the human body. However, some external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals can also increase the expression of free radicals in the body.
Free radicals are unstable molecules with the unpaired electron in the outer ring and ready to donate or steal an electron from another molecule, leading to the chain reaction until they are stopped by the presence of the antioxidants or their outer ring are paired.
Overexpression of free radical chain reactive in the human body has been known to induce oxidative stress, causing damage to the cells, proteins, and alternation of cell DNA. In this case, the application of an external source of antioxidants such as synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole may be helpful to restore the balance of these 2 types of molecule.
Hydroxyl radicals, superoxide anion radicals, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radicals, and peroxynitrite radicals are hight reactive and important free radicals associated with many chronic diseases.
Dr. V. Lobo, concerned about the overexpression of free radicals in the induction of, various human chronic illnesses conducted a study to examine the impacts of free radicals, antioxidants and functional foods in human health said in summary, "Free radicals damage contributes to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer. Antioxidants prevent free radical-induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition".
(More importantly)" Synthetic antioxidants are recently reported to be dangerous to human health. Thus the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. In addition to endogenous antioxidant defense systems, consumption of dietary and plant-derived antioxidants appears to be a suitable alternative. Dietary and other components of plants form a major source of antioxidants".
Butterbur, found in wet, marshy, damp land, including wetlands, Riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.
The herbal plant has been used in traditional medicine as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
In the finding of the natural ingredient from the botanical plants which process a significant antioxidant activity without inducing any side effects, researchers at the Second Military Medical University looked into a bioactive compound isolated from the herbal Butterbur.
Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus.
All 4 compounds demonstrated neuroprotective activity by reversing the neuron's damage exposed to oxygen-glucose deprivation and oxidative insults.
The results of this efficacy were associated with the antioxidant properties of the 4 compounds in inhibiting the oxidative stress caused by the oxygen-glucose deprivation.
The finding indicated that herbal Butterbur not only processed a significant activity in protecting the brain cells against oxidative stress due to overexpression of free radicals but also promoted the production of antioxidant enzymes in the host tissue.
In hyphenated HPLC techniques used to identify the structures and antioxidant activities without prior purification of compounds, researchers found that herbal Butterbur process a number of bioactive compounds, including 5-caffeoylquinic acid (5-CQA), fukinolic acid (FA), 3,5-di-O-caffeoylquinic acid (3,5-DCQA) exert a strong antioxidant free radical scavenging activity.
The greatest radical scavenging capacity was found in the leaf (23.09% of total antioxidant capacity) and root (26.47%) extracts.
The relative radical scavenging portion of quercetin-3-O-(6″-acetyl)-β-glucopyranoside (QAG) was only 3.41% in the leaves and KAG did not show any radical scavenging activity.
These results firmly suggested that herbal Butterbur processes a significant antioxidant property. However, a single ingredient isolated from the herb may express different levels of antioxidants in a dose-depending manner.
Therefore, herbal Butterbur containing a high amount of antioxidants and bioactive compounds free radical scavengers may be considered a functional food for the promotion of antioxidant activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(2) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
Thursday, 3 August 2023
#Pomace of #Tomato and Grape Shows a Significant Effect on #Hyperlipidemia Induced Neurons Damage in Diabetes, Scientists Say
Kyle J. Norton
Hyperlipidemia is a condition of abnormally high blood cholesterol in the bloodstream. The condition is also a member of the cluster of metabolic syndrome associated with the risk of type II diabetes and cardiovascular disease.
Cholesterol is a waxy substance with a double-edged sword. On one hand, cholesterol is essential for the body to build strong cellular membranes, production of steroid hormones, and vitamin D and aid digestion, on another hand, it also causes a number of diseases if overexpressed in the blood.
Cholesterol is either produced by the liver or by the intake of fat.
There are 2 types of cholesterol in the body, low-density lipoprotein (LDL, bad cholesterol) and high-density lipoprotein (good cholesterol).
Where high-density lipoprotein (HDL, good cholesterol) plays a critical role to return the cholesterol to the liver for future use. Low levels of high-density or high levels of lipoproteins may result in blood cholesterol accumulating in the blood, leading to high blood cholesterol.
The optimized ratio of LDL/ HDL is any number that is less than 4.
Dr. Joan Carles Escola`-Gil, the lead scientist in the evaluation of the Western diet risk of high blood cholesterol wrote, ". The HFHC diet caused a significant increase in plasma cholesterol, HDL cholesterol, and liver cholesterol and enhanced macrophage-derived [ 3 H]cholesterol flux to feces by 3- to 4-fold".
In other words, long-term intake of high-fat diet-induced hyperlipidemia.
Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient or whole food for the treatment of hyperlipidemia, researchers examined the effect of tomato and grape pomace on the cholesterol (0.3%) diet of male Wistar rats produced a dose-dependent effect.
During the experiment, researchers found that 5% pomace of either grape or combination showed no effects on reduced levels of hyperlipidemia.
However, 15% pomace of tomato and grape reduced serum cholesterol levels from 4.4 mmol/L to 2.5 mmol/L and 2.0 mmol/L respectively.
Interestingly, at the concentration of 15%, both tomato and grape pomace induced a redistribution of cholesterol in lipoproteins associated with an anti-atherogenic profile and reduced cholesterol concentration in very-low-density lipoprotein (VDL) (24% [tomato], 50% [grape]) and low-density lipoprotein (LDL) (3-fold, 3.6-fold).
Furthermore, both types of pomace enhanced the function of HDL in cholesterol transport by reducing the VLDL and LDL contribution.
Moreover, tomato and grape pomace reduced plasma levels of conjugated dienes involved in cholesterol oxidation in high levels by 30-50%
Additionally, injection also improved the antioxidant enzymes in the liver against lipid peroxidation.
In rats fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1, researchers found that injection of all doses of lycopene exerted a statistical significance in reduced the levels of cholesterol observed by inverse U shape at the 4 weeks of the experiment.
Furthermore, serum lycopene concentration was negatively correlated with the levels of serum TC, and LDL-C, particularly in the cerebral LDL-C.
Serum lycopene concentration was also found to have a positive correlation with the expression of Claudin-5 associated with brain microvascular endothelial cell proliferation, and migration. and the number of neurons in hippocampal CA1 and CA3.
In other words, serum lycopene showed a strong effect on the protection of neurons against hyperlipidemia in the brain that facilitates neuron damage.
Dr. Wang W, the lead scientist said, "These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia".
Taken altogether, tomatoes processed with high amounts of lycopene may be considered supplements for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The dose-response effect of lycopene on cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)
(2) Dietary tomato and grape pomace in rats: effect on lipids in serum and liver, and on antioxidant status by Bobek P. (PubMed)
(3) The Cholesterol Content of Western Diets Plays a Major Role in the Paradoxical Increase in High-Density Lipoprotein Cholesterol and Upregulates the Macrophage Reverse Cholesterol Transport Pathway by Joan Carles Escola`-Gil, Gemma Llaverias, Josep Julve, Matti Jauhiainen,Jesu´s Me´ndez-Gonza´lez, Francisco Blanco-Vaca
Hyperlipidemia is a condition of abnormally high blood cholesterol in the bloodstream. The condition is also a member of the cluster of metabolic syndrome associated with the risk of type II diabetes and cardiovascular disease.
Cholesterol is a waxy substance with a double-edged sword. On one hand, cholesterol is essential for the body to build strong cellular membranes, production of steroid hormones, and vitamin D and aid digestion, on another hand, it also causes a number of diseases if overexpressed in the blood.
Cholesterol is either produced by the liver or by the intake of fat.
There are 2 types of cholesterol in the body, low-density lipoprotein (LDL, bad cholesterol) and high-density lipoprotein (good cholesterol).
Where high-density lipoprotein (HDL, good cholesterol) plays a critical role to return the cholesterol to the liver for future use. Low levels of high-density or high levels of lipoproteins may result in blood cholesterol accumulating in the blood, leading to high blood cholesterol.
The optimized ratio of LDL/ HDL is any number that is less than 4.
Dr. Joan Carles Escola`-Gil, the lead scientist in the evaluation of the Western diet risk of high blood cholesterol wrote, ". The HFHC diet caused a significant increase in plasma cholesterol, HDL cholesterol, and liver cholesterol and enhanced macrophage-derived [ 3 H]cholesterol flux to feces by 3- to 4-fold".
In other words, long-term intake of high-fat diet-induced hyperlipidemia.
Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient or whole food for the treatment of hyperlipidemia, researchers examined the effect of tomato and grape pomace on the cholesterol (0.3%) diet of male Wistar rats produced a dose-dependent effect.
During the experiment, researchers found that 5% pomace of either grape or combination showed no effects on reduced levels of hyperlipidemia.
However, 15% pomace of tomato and grape reduced serum cholesterol levels from 4.4 mmol/L to 2.5 mmol/L and 2.0 mmol/L respectively.
Interestingly, at the concentration of 15%, both tomato and grape pomace induced a redistribution of cholesterol in lipoproteins associated with an anti-atherogenic profile and reduced cholesterol concentration in very-low-density lipoprotein (VDL) (24% [tomato], 50% [grape]) and low-density lipoprotein (LDL) (3-fold, 3.6-fold).
Furthermore, both types of pomace enhanced the function of HDL in cholesterol transport by reducing the VLDL and LDL contribution.
Moreover, tomato and grape pomace reduced plasma levels of conjugated dienes involved in cholesterol oxidation in high levels by 30-50%
Additionally, injection also improved the antioxidant enzymes in the liver against lipid peroxidation.
In rats fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1, researchers found that injection of all doses of lycopene exerted a statistical significance in reduced the levels of cholesterol observed by inverse U shape at the 4 weeks of the experiment.
Furthermore, serum lycopene concentration was negatively correlated with the levels of serum TC, and LDL-C, particularly in the cerebral LDL-C.
Serum lycopene concentration was also found to have a positive correlation with the expression of Claudin-5 associated with brain microvascular endothelial cell proliferation, and migration. and the number of neurons in hippocampal CA1 and CA3.
In other words, serum lycopene showed a strong effect on the protection of neurons against hyperlipidemia in the brain that facilitates neuron damage.
Dr. Wang W, the lead scientist said, "These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia".
Taken altogether, tomatoes processed with high amounts of lycopene may be considered supplements for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The dose-response effect of lycopene on cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)
(2) Dietary tomato and grape pomace in rats: effect on lipids in serum and liver, and on antioxidant status by Bobek P. (PubMed)
(3) The Cholesterol Content of Western Diets Plays a Major Role in the Paradoxical Increase in High-Density Lipoprotein Cholesterol and Upregulates the Macrophage Reverse Cholesterol Transport Pathway by Joan Carles Escola`-Gil, Gemma Llaverias, Josep Julve, Matti Jauhiainen,Jesu´s Me´ndez-Gonza´lez, Francisco Blanco-Vaca
#Broccoli Enhances Several Xenobiotics Metabolizing Genes Associated with a Reduced Risk of #Cancer, Researchers Say
Kyle J. Norton
Xenobiotic metabolism is an action that protects the host against chemicals that affect normal metabolism.
Other common metabolisms may include
* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, and also has been found to protect the gut mucosal barrier in preserving the ability to absorb nutrients.
* Drug metabolism is the process to alter chemicals of a drug that may cause harm to the body
The gut microbiota plays a critical role in regulating the systemic metabolism of the host including producing vitamins, synthesizing all essential and nonessential amino acids, and carrying out biotransformation of bile by interacting with other organs such as the intestine, liver, brain, and other organs through the host-microbiota and co-metabolism structure to form an ametabolic axis.
More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of dietary nutrients in the digestive system
* Gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.
* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestine in nutrient adsorption.
* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
The imbalance of the ratio of gut microbiota may have a negative impact on human health and diseases.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF), the isothiocyanate derived from 4-methyl-sulphinyl butyl glucosinolate in broccoli induce-xenobiotic metabolizing.
The study included 16 subjects randomized, into a 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.
According to the results of the trial, consumption of high glucosinolate broccoli showed a strong effect in the improvement of several xenobiotics metabolizing genes, including thioredoxin reductase, Aldo-keto reductases, and glutamate-cysteine ligase modifier subunit.
Furthermore, the affected genes also have been found to be improved after exposure to SF, in cell and animal models.
Compared to phytochemical sulforaphane (SF) and sulforaphane (SF), only 1 such gene was affected in the consumption of standard broccoli.
Taken together, the consequences of these results suggest that the broccoli processes the potential anticarcinogenic activity by upregulating the gene associated with xenobiotic metabolism, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Consuming broccoli does not induce genes associated with xenobioticmetabolism and cell cycle control in human gastric mucosa by Gasper AV1, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barrett DA, Mithen RF. (PubMed)
Xenobiotic metabolism is an action that protects the host against chemicals that affect normal metabolism.
Other common metabolisms may include
* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, and also has been found to protect the gut mucosal barrier in preserving the ability to absorb nutrients.
* Drug metabolism is the process to alter chemicals of a drug that may cause harm to the body
The gut microbiota plays a critical role in regulating the systemic metabolism of the host including producing vitamins, synthesizing all essential and nonessential amino acids, and carrying out biotransformation of bile by interacting with other organs such as the intestine, liver, brain, and other organs through the host-microbiota and co-metabolism structure to form an ametabolic axis.
More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of dietary nutrients in the digestive system
* Gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.
* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestine in nutrient adsorption.
* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
The imbalance of the ratio of gut microbiota may have a negative impact on human health and diseases.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF), the isothiocyanate derived from 4-methyl-sulphinyl butyl glucosinolate in broccoli induce-xenobiotic metabolizing.
The study included 16 subjects randomized, into a 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.
According to the results of the trial, consumption of high glucosinolate broccoli showed a strong effect in the improvement of several xenobiotics metabolizing genes, including thioredoxin reductase, Aldo-keto reductases, and glutamate-cysteine ligase modifier subunit.
Furthermore, the affected genes also have been found to be improved after exposure to SF, in cell and animal models.
Compared to phytochemical sulforaphane (SF) and sulforaphane (SF), only 1 such gene was affected in the consumption of standard broccoli.
Taken together, the consequences of these results suggest that the broccoli processes the potential anticarcinogenic activity by upregulating the gene associated with xenobiotic metabolism, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Consuming broccoli does not induce genes associated with xenobioticmetabolism and cell cycle control in human gastric mucosa by Gasper AV1, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barrett DA, Mithen RF. (PubMed)
#Cranberry Increases Antixidant Capacity Agaainst Oxidativestress, According to Studies
Kyle J. Norton
Free radicals are unstable molecules with unpaired electrons in the outermost ring produced daily internally including cell metabolism and externally including the air we breathe and the food we eat.
Reactive oxygen species and reactive nitrogen without being controlled by antioxidants can induce a domino effect by stealing an electron from other molecules, leading to a continued reaction that cannot stop until all single electrons are paired or inhibited by the presence of antioxidant molecules.
Antioxidants are stable atoms produced either by the host body or by intake of dietary antioxidant-rich food.
In this cascade, free radicals overexpression induces oxidative stress. A major cause of protein, lipid, and cell damage increased risk of the early onset of many chronic diseases.
In other words, oxidative stress is an imbalanced ratio of free radicals and antioxidants.
The most common diseases or syndromes associated with the onset of oxidative stress are
* Aging, is a process characterized by the progressive loss of tissue and organ function due to the accumulation of RONS-induced damages.
* Cardiovascular diseases (CVD) are diseases associated with involving the heart or blood vessels, including heart disease, and stroke.
* Chronic obstructive pulmonary disease (COPD) is a class of lung diseases including chronic bronchitis and emphysema. Most cases of COPD are caused by smoking.
* Chronic kidney disease is a medical condition that causes the gradual loss of kidney function kidney affecting filter wastes and excess fluids from the blood.
* Neurodegenerative diseases is the progressive loss of structure or function of neurons, including dementia.
* Cancer is a class of diseases caused by irregular cell growth due to the alternation of cell DNA
There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, and air pollutants.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of cranberry products and especially cranberry juice (CJ) antioxidant activity.
According to the tested analysis on the products, the order of the number of total polyphenols that exert antioxidant activity in cranberry foods on a fresh weight basis is dried > frozen > sauce > jellied sauce. in the deceased order.
Furthermore, in the comparison of the effect of the consumption of high fructose corn syrup (HFCS) and ascorbate with CJ antioxidants or without CJ (control) given to 10 normal individuals after an overnight fast, by recording the plasma antioxidant capacity, glucose, triglycerides, and ascorbate measured 6 times over 7 h after the consumption of a single 240 mL serving of the two different beverages, researchers found that* HFCS caused a slight decrease in plasma antioxidant capacity at all time points and thus inducing oxidative stress with or without ascorbate
*CJ produced an increase in plasma antioxidant capacity at all time points, particularly compared to
HFCS.
Furthermore, postprandial triglycerides-induced oxidative stress caused by HFCS were associated with the oxidative stress in HFCS treated group.
Based on the findings, researchers said, " Cranberries are an excellent source of high-quality antioxidants and should be examined in human supplementation studies".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry by Baranowska M1, Bartoszek A. (PubMed)
(2) Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants by Vinson JA1, Bose P, Proch J, Al Kharrat H, Samman N. (PubMed)
Free radicals are unstable molecules with unpaired electrons in the outermost ring produced daily internally including cell metabolism and externally including the air we breathe and the food we eat.
Reactive oxygen species and reactive nitrogen without being controlled by antioxidants can induce a domino effect by stealing an electron from other molecules, leading to a continued reaction that cannot stop until all single electrons are paired or inhibited by the presence of antioxidant molecules.
Antioxidants are stable atoms produced either by the host body or by intake of dietary antioxidant-rich food.
In this cascade, free radicals overexpression induces oxidative stress. A major cause of protein, lipid, and cell damage increased risk of the early onset of many chronic diseases.
In other words, oxidative stress is an imbalanced ratio of free radicals and antioxidants.
The most common diseases or syndromes associated with the onset of oxidative stress are
* Aging, is a process characterized by the progressive loss of tissue and organ function due to the accumulation of RONS-induced damages.
* Cardiovascular diseases (CVD) are diseases associated with involving the heart or blood vessels, including heart disease, and stroke.
* Chronic obstructive pulmonary disease (COPD) is a class of lung diseases including chronic bronchitis and emphysema. Most cases of COPD are caused by smoking.
* Chronic kidney disease is a medical condition that causes the gradual loss of kidney function kidney affecting filter wastes and excess fluids from the blood.
* Neurodegenerative diseases is the progressive loss of structure or function of neurons, including dementia.
* Cancer is a class of diseases caused by irregular cell growth due to the alternation of cell DNA
There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, and air pollutants.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of cranberry products and especially cranberry juice (CJ) antioxidant activity.
According to the tested analysis on the products, the order of the number of total polyphenols that exert antioxidant activity in cranberry foods on a fresh weight basis is dried > frozen > sauce > jellied sauce. in the deceased order.
Furthermore, in the comparison of the effect of the consumption of high fructose corn syrup (HFCS) and ascorbate with CJ antioxidants or without CJ (control) given to 10 normal individuals after an overnight fast, by recording the plasma antioxidant capacity, glucose, triglycerides, and ascorbate measured 6 times over 7 h after the consumption of a single 240 mL serving of the two different beverages, researchers found that* HFCS caused a slight decrease in plasma antioxidant capacity at all time points and thus inducing oxidative stress with or without ascorbate
*CJ produced an increase in plasma antioxidant capacity at all time points, particularly compared to
HFCS.
Furthermore, postprandial triglycerides-induced oxidative stress caused by HFCS were associated with the oxidative stress in HFCS treated group.
Based on the findings, researchers said, " Cranberries are an excellent source of high-quality antioxidants and should be examined in human supplementation studies".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry by Baranowska M1, Bartoszek A. (PubMed)
(2) Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants by Vinson JA1, Bose P, Proch J, Al Kharrat H, Samman N. (PubMed)
#RedCabbage Processes Anti-Mammalian #Cancer Activity through Activiting the Cytototic and Inflammatory Pathways Induced Cancer Cell's DNA Damage
Kyle J. Norton
Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where the cancer begins.
As of today, researchers do not know what are the exact causes of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.
Genetic mutation of BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and the alternation of gene PTEN.that suppress the growth of tumors also increases the risk of cancers.
According to the statistic provided by the UK Cancers Research, in 2012, an estimated 14.1 million new cases of cancer occurred worldwide.
Sadly, more than 4 in ten cancers occurring worldwide are in countries at a low or medium level of the Human Development Index (HDI).
The four most common types of human cancer, occurring worldwide are
* Lung Cancer
Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, In 2015, approximately 26,600 Canadians will be diagnosed with lung cancer and 20,900 will die of it.
* Female breast cancer
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.
Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.
* Colorectal cancer
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of the cell's DNA.
Colorectal cancer is a relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
* Prostate cancer
Prostate cancer is defined as a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth which spread to distant parts of the body. Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during Physical (rectum) exams.
Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.
Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe. The veggie leave is highly nutritious and cultivated as foods in most parts of Europe.
In finding a potent compound for the prevention and treatment of cancers, researchers examined, in vitro cytotoxic effects and the mode of interaction of biologically synthesized Ag and Au nanoparticles (NPs) using Brassica oleracea L. var. capitata f. Rubra (BOL) against HT-1080 cancer cells and bacterial cells.
According to the tested analysis,* The Ag NPs showed a stronger free radical scavenging activity in vitro compared to the Au NPs.
* Both nanoparticles (NPs) exerted cytotoxic effects mediated through nuclear morphological changes and DNA damage.
* Intracellular localization of Ag and Au NPs induced HT-1080 cancer cell apoptosis.
These results strongly suggested that the Ag and Au NPs have easily entered and accumulated into the cytosol and nucleus to activate the inflammatory and apoptosis pathways to induce damage in cancer cell DNA.
Most importantly, Ag and Au NPs showed no clear toxic effects and no nuclear abnormalities in peripheral blood cells
Taken altogether, red cabbage may be considered a functional food for the treatment of mammalian cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Interaction of silver and gold nanoparticles in mammalian cancer: as a real topical bullet for wound healing- A comparative study by Sivakumar AS1, Krishnaraj C2, Sheet S3, Rampa DR4, Kang DR1, Belal SA1, Kumar A5, Hwang IH6, Yun SI2, Lee YS3, Shim KS. (PubMed)
Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where the cancer begins.
As of today, researchers do not know what are the exact causes of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.
Genetic mutation of BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and the alternation of gene PTEN.that suppress the growth of tumors also increases the risk of cancers.
According to the statistic provided by the UK Cancers Research, in 2012, an estimated 14.1 million new cases of cancer occurred worldwide.
Sadly, more than 4 in ten cancers occurring worldwide are in countries at a low or medium level of the Human Development Index (HDI).
The four most common types of human cancer, occurring worldwide are
* Lung Cancer
Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, In 2015, approximately 26,600 Canadians will be diagnosed with lung cancer and 20,900 will die of it.
* Female breast cancer
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.
Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.
* Colorectal cancer
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of the cell's DNA.
Colorectal cancer is a relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
* Prostate cancer
Prostate cancer is defined as a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth which spread to distant parts of the body. Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during Physical (rectum) exams.
Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.
Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe. The veggie leave is highly nutritious and cultivated as foods in most parts of Europe.
In finding a potent compound for the prevention and treatment of cancers, researchers examined, in vitro cytotoxic effects and the mode of interaction of biologically synthesized Ag and Au nanoparticles (NPs) using Brassica oleracea L. var. capitata f. Rubra (BOL) against HT-1080 cancer cells and bacterial cells.
According to the tested analysis,* The Ag NPs showed a stronger free radical scavenging activity in vitro compared to the Au NPs.
* Both nanoparticles (NPs) exerted cytotoxic effects mediated through nuclear morphological changes and DNA damage.
* Intracellular localization of Ag and Au NPs induced HT-1080 cancer cell apoptosis.
These results strongly suggested that the Ag and Au NPs have easily entered and accumulated into the cytosol and nucleus to activate the inflammatory and apoptosis pathways to induce damage in cancer cell DNA.
Most importantly, Ag and Au NPs showed no clear toxic effects and no nuclear abnormalities in peripheral blood cells
Taken altogether, red cabbage may be considered a functional food for the treatment of mammalian cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Interaction of silver and gold nanoparticles in mammalian cancer: as a real topical bullet for wound healing- A comparative study by Sivakumar AS1, Krishnaraj C2, Sheet S3, Rampa DR4, Kang DR1, Belal SA1, Kumar A5, Hwang IH6, Yun SI2, Lee YS3, Shim KS. (PubMed)
#Cucumber's Cucurbitacin B Inhibits Genes Associated with the Promotion of #HeartHealth, According to Studies
Kyle J. Norton
The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.
Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.
According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting for 1 in 4 deaths.
The most common symptoms of heart disease are poor appetite, weight loss, shortness of breath, sudden collapse, blood clots and stunted growth found in children.
If you have experienced some of the aforementioned symptoms, please check with your doctor to rule the risk of heart disease.
By following a healthy dietary intake, physical activity, weight management, smoking cessation, blood pressure control, and lipid management, most cases of heart disease are preventable.
Dr. Melanie Warziski Turk, in the evaluation of the risk of heart disease in women, wrote, "Because heart disease is frequently preventable, increasing awareness of personal risk and preventative measures is a key element of healthcare for women".
And, "Nurse clinicians can evaluate, educate, and counsel women regarding their risk for this pervasive disease and promote behavior changes that will decrease that risk. Research evidence supports that lifestyle behaviors are the cornerstone of heart disease prevention".
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural compound for the improvement of heart health, researchers investigated the therapeutic impact of cucurbitacin I on the heart.
According to the tested assay, phenylephrine (PE)-induced muscle cell enlargement and cardiac hypertrophy was inhibited by the pretreatment of the cardiomyocytes with cucurbitacin I.
Furthermore, cucurbitacin I protect the heart connective tissues against the onset of cardiac fibrosis.
More importantly, cucurbitacin I also significantly expressed the heart muscle protective effect by inhibiting the factors associated with the increase of blood pressure.
In order to reveal more information about cucumber anti-cardiac hypertrophy, a leading cause of heart failure, researchers evaluated cucurbitacin B anti-hypertrophy and anti-fibrosis potential both in vitro and in vivo.
Selected mice induced cardiac hypertrophy after 1 week of surgery, were given cucurbitacin B treatment for 4 weeks.
At the end of the experiment, cucurbitacin B demonstrated strong anti-hypertrophy and anti-fibrosis ability evidenced by decreased heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.
Additionally, the levels of heart systolic and diastolic abnormalities induced by the surgery were also moralized by the application of cucurbitacin B.
Furthermore, gene expressions induced hypertrophic and fibrotic markers, and reserved microvascular density in pressure overload-induced hypertrophic mice were also normalized by the injection of cucurbitacin B.
Taken together, cucumber and its bioactive compound cucurbitacin I and B (CuB) may be used for the improvement of heart health, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings by Moon Hee Jeong,# 1 Shang-Jin Kim,# 2 Hara Kang, 3 Kye Won Park, 4 Woo Jin Park, 1Seung Yul Yang, 5 and Dong Kwon Yang. (PMC)
(2) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Yang Xiao, Zheng Yang, Qing-Qing Wu, and Xiao-Han Jiang. (Research Gate)
(3) Cardiac Health: Primary Prevention of Heart Disease in Women by Melanie Warziski Turk, Ph.D., MSN, RN, a Patricia K. Tuite, MSN, RN,b and Lora E. Burke, Ph.D., MPH, FAHA, FAAN. (PMC)
The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.
Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.
According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting for 1 in 4 deaths.
The most common symptoms of heart disease are poor appetite, weight loss, shortness of breath, sudden collapse, blood clots and stunted growth found in children.
If you have experienced some of the aforementioned symptoms, please check with your doctor to rule the risk of heart disease.
By following a healthy dietary intake, physical activity, weight management, smoking cessation, blood pressure control, and lipid management, most cases of heart disease are preventable.
Dr. Melanie Warziski Turk, in the evaluation of the risk of heart disease in women, wrote, "Because heart disease is frequently preventable, increasing awareness of personal risk and preventative measures is a key element of healthcare for women".
And, "Nurse clinicians can evaluate, educate, and counsel women regarding their risk for this pervasive disease and promote behavior changes that will decrease that risk. Research evidence supports that lifestyle behaviors are the cornerstone of heart disease prevention".
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural compound for the improvement of heart health, researchers investigated the therapeutic impact of cucurbitacin I on the heart.
According to the tested assay, phenylephrine (PE)-induced muscle cell enlargement and cardiac hypertrophy was inhibited by the pretreatment of the cardiomyocytes with cucurbitacin I.
Furthermore, cucurbitacin I protect the heart connective tissues against the onset of cardiac fibrosis.
More importantly, cucurbitacin I also significantly expressed the heart muscle protective effect by inhibiting the factors associated with the increase of blood pressure.
In order to reveal more information about cucumber anti-cardiac hypertrophy, a leading cause of heart failure, researchers evaluated cucurbitacin B anti-hypertrophy and anti-fibrosis potential both in vitro and in vivo.
Selected mice induced cardiac hypertrophy after 1 week of surgery, were given cucurbitacin B treatment for 4 weeks.
At the end of the experiment, cucurbitacin B demonstrated strong anti-hypertrophy and anti-fibrosis ability evidenced by decreased heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.
Additionally, the levels of heart systolic and diastolic abnormalities induced by the surgery were also moralized by the application of cucurbitacin B.
Furthermore, gene expressions induced hypertrophic and fibrotic markers, and reserved microvascular density in pressure overload-induced hypertrophic mice were also normalized by the injection of cucurbitacin B.
Taken together, cucumber and its bioactive compound cucurbitacin I and B (CuB) may be used for the improvement of heart health, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings by Moon Hee Jeong,# 1 Shang-Jin Kim,# 2 Hara Kang, 3 Kye Won Park, 4 Woo Jin Park, 1Seung Yul Yang, 5 and Dong Kwon Yang. (PMC)
(2) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Yang Xiao, Zheng Yang, Qing-Qing Wu, and Xiao-Han Jiang. (Research Gate)
(3) Cardiac Health: Primary Prevention of Heart Disease in Women by Melanie Warziski Turk, Ph.D., MSN, RN, a Patricia K. Tuite, MSN, RN,b and Lora E. Burke, Ph.D., MPH, FAHA, FAAN. (PMC)
#Lycopene Found in Tomato Improves Pancreas function in Diabetics in Vivo, According to Studies
Kyle J. Norton
The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids. Traditional Chinese medicine views the pancreas as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.
The effects of the pancreas on diabetes
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, is the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.
As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.
* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body metabolized glucose. In other words, most cases of type 2 diabetes are results of insulin receptors clogged-up by fat and cholesterol, leading to resist the effects of the hormone insulin that regulates the movement of sugar into your cells.
* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.
Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.
According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of diabetes, researchers examined the role of lycopene (L) on the changes occurring in estrogen receptor (ER) α-positive cells and oxidative stress markers in the pancreas of experimentally induced adult diabetic rats.
According to the results from a single dose of 50 mg/kg streptozotocin (STZ), t5o induce diabetes in rats, divided into four groups: Control + corn oil, control + lycopene, diabetic + corn oil, and diabetic + lycopene.
Diabetic groups showed a higher number of proliferating Ki-67 positive cells without affecting apoptotic cell number compared to control.
In lycopene treatment groups
* Lycopene first time treated group showed with the presence of ER α-positive cells around the islets did not have any effect on any of the parameters aforementioned in diabetic groups.
* Increasing the dose and/or the duration of lycopene demonstrated the antioxidant effects on the pancreas of diabetic rats observed by lowering oxidative stress
Taken together, long-term lycopene intake may be considered supplements for the improvement of pancreas function in the diabetics, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Changes in the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Proliferating, Apoptotic, and Estrogen Receptor α Positive Cells by Sandikci M1, Karagenc L1, Yildiz M. (PubMed)
(2) Changes in rat ovary with experimentally induced diabetes and the effects of lycopene on those changes in Yildiz M1, Sandikci M. (PubMed)
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