Kyle J. Norton
A mammary tumor is a medical and chronic condition originating from the milk-producing gland.
The mammary gland located in the breasts of females is responsible for lactation.
Most cases of mammary cancer are first found in the cell on the surface of the inner lining of the milk-producing gland, before penetrating deeper into the layers.
At the advanced stage, the malignant cancer cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.
Epidemiologically, mammary cancer has been found to spread to the colon and the liver.
The most common risk factors of mammary cancer are similar to those of breast cancer, inclduing, aging, physical inactivity, being obese or overweight, family and personal history, having a dense breast, radiation therapy, pregnancy history, genetic proposition, particularly in women who had used drug diethylstilbestrol (DES).
Out of all the aforementioned risk factors, some researchers suggested that the promotion of high-fat-diet-induced a high percentage of obese US females may be the major culprit that causes the rise of mammary cancer.
Dr. Valeria Simone, the lead scientist in the examination of the molecule interconnection of obesity and breast cancer risk wrote, "Obesity is an important risk factor for breast cancer (BC) in postmenopausal women; interlinked molecular mechanisms might be involved in the pathogenesis. Increased levels of estrogens due to aromatization of the adipose tissue, inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and prostaglandin E2, insulin resistance and hyperactivation of insulin-like growth factors pathways, adipokines, and oxidative stress are all abnormally regulated in obese women and contribute to cancerogenesis".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against mammary carcinoma, researchers examined the bromelain autophagic phenomenon in mammary carcinoma cells (estrogen receptor positive and negative).
According to the tested assays, bromelain showed delayed growth inhibitory response and induction of autophagy, in MCF-7 cells.
Bromelain-induced cancer cell apoptosis was found in the sub-G1 cell fraction and apoptotic features associated with chromatin condensation change and cell division.
Interestingly, in the presence of an anti-apoptotic protein that augments the autophagy levels, bromelain inhibited morphological apoptosis but did not prevent cell death.
In other words, bromelain induced cancer cell death by inhibiting the expression of signaling cascade associated with the phosphorylation of extracellular signal-regulated kinase ½ (ERK½) and exhibiting the proapoptotic kinases (c-jun N-terminal kinase (JNK) and p38 kinase).
Based on the findings, researchers said, "bromelain-induced autophagy was positively regulated by p38 and JNK but negatively regulated by ERK½. Autophagy-inducing property of bromelain can be further exploited in breast cancer therapy".
In order to reveal more information about bromelain anti-mammary carcinoma properties, researchers examined the enzyme effect on GI-101A breast cancer cells.
According to the results from GI-101A cells treated with increasing concentrations of bromelain for 24 hours, bromelain induced cancer cell death via activation of the apoptosis mechanisms.
Observation of the results from the caspase-9 and caspase-3 assays, bromelain exhibited a prominent effect to induce cancer cell apoptosis correlated with the elevation of plasma cytokeratin 18 (CK-18) fragment levels, a marker of cell death.
The inhibition of bromelain against cancer cell proliferation was also evident by the DNA fragmentation analysis and 4,6'-diamino-2-phenylindole dihydrochloride fluorescence staining of the nucleus.
Taken together, bromelain may be considered supplements for the prevention and treatment of mammary carcinoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells by Bhui K1, Tyagi S, Prakash B, Shukla Y. (PubMed)
(2) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S1, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A. (PubMed)
(3) Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications
by Valeria Simone, Morena D’Avenia, Antonella Argentiero, Claudia Felici,Francesca Maria Rizzo, Giovanni De Pergola and Franco Silvestris. (The Oncologist)
Tuesday, 1 August 2023
#Herbal #Bilberry Protects the Hippocampal and Retinal Neurons Against Toxicity in Diabetes through Its Antioxidants Activity, Researchers Suggest
Kyle J. Norton
Neuro-toxicity is a condition of brain damage caused by exposure to toxic substances.
The toxic condition was found to reduce the brain function in transmitting and processing signals to other parts of the nervous system.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
According to the statistics provided by the University of Ibadan, in the United States, for instance, out of 63 million youths under 18 years of age, about 10% have diagnosable neurobehavioural problems with only 20% receiving therapy and the magnitude affected by neurotoxicity is unknown.
The University continued, "The adverse effects of neurotoxicity are among the most feared ill health in humans because they adversely affect the quality of life", and "Undoubtedly, the magnitude and potential severity of neurotoxicity problems make it imperative to invest in resources required to strengthen the basis for preventive intervention, the forerunner of which is the development of biomarkers for neurotoxicity at the individual and population levels".
In other words, out of millions of people who have neurobehavioural problems, researchers do not know how many of them are actually caused by toxicity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the analysis of natural compounds with neuroprotective effects in patients with diabetes, researchers examined the antioxidants richly present in bilberry fruits' effects on diabetes-related brain dysfunctions.
The study included the differentiation of the expression patterns of αCaMKII in hippocampal neurons from non-diabetic, diabetic, and diabetic rats fed with an extract of bilberry fruit.
Where Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) plays a significant role in cognitive processes.
Diabetic rats' hippocampal neurons immunoreactive (ir) to αCaMKII were swollen and the lengths of the neuronal fibers were reduced compared to the significantly longer αCaMKII-positive nerve fibers in diabetic rats fed with bilberry fruit.
Injection of bilberry fruit also induced significant changes in the average larger diameter of αCaMKII-ir hippocampal neurons.
The results suggested that bilberry fruits exerted a neuroprotective effect on hippocampal neurons in diabetes through its antioxidants activity.
Furthermore, in order to find more information about the bilberry effect on the brain, researchers examined it's anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) neuroprotective effect against retinal damage in vitro and in vivo.
In RGC cultures, VMA and all three anthocyanidins protected the brain against SIN-1 (chloride) toxicity, inhibited lipid peroxidation in mouse forebrain homogenates through the antioxidant property and NMDA-induced morphological retinal damage by allowing high levels of calcium ions (Ca2+) to enter the cells.
Moreover, VMA and all three anthocyanidins also protected the retinal damage by increasing the TUNEL-positive cells in the ganglion cell layer.
Dr. Matsunaga N, the lead scientist said, "VMA and its anthocyanidins have neuroprotective effects (exerted at least in part via an anti-oxidation mechanism) in these in vitro and in vivo models of retinal diseases".
Taken together, bilberry may be considered a functional food for the prevention and treatment of neurological diseases associated with neurotoxicity, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
(3) Environmental Chemicals and Human Neurotoxicity: Magnitude, Prognosis and Markers by Anetor J. I. 1, Anetor G.O. 2, Iyanda AA1 , Adeniyi FAA. (the University of Ibadan)
Neuro-toxicity is a condition of brain damage caused by exposure to toxic substances.
The toxic condition was found to reduce the brain function in transmitting and processing signals to other parts of the nervous system.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
According to the statistics provided by the University of Ibadan, in the United States, for instance, out of 63 million youths under 18 years of age, about 10% have diagnosable neurobehavioural problems with only 20% receiving therapy and the magnitude affected by neurotoxicity is unknown.
The University continued, "The adverse effects of neurotoxicity are among the most feared ill health in humans because they adversely affect the quality of life", and "Undoubtedly, the magnitude and potential severity of neurotoxicity problems make it imperative to invest in resources required to strengthen the basis for preventive intervention, the forerunner of which is the development of biomarkers for neurotoxicity at the individual and population levels".
In other words, out of millions of people who have neurobehavioural problems, researchers do not know how many of them are actually caused by toxicity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the analysis of natural compounds with neuroprotective effects in patients with diabetes, researchers examined the antioxidants richly present in bilberry fruits' effects on diabetes-related brain dysfunctions.
The study included the differentiation of the expression patterns of αCaMKII in hippocampal neurons from non-diabetic, diabetic, and diabetic rats fed with an extract of bilberry fruit.
Where Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) plays a significant role in cognitive processes.
Diabetic rats' hippocampal neurons immunoreactive (ir) to αCaMKII were swollen and the lengths of the neuronal fibers were reduced compared to the significantly longer αCaMKII-positive nerve fibers in diabetic rats fed with bilberry fruit.
Injection of bilberry fruit also induced significant changes in the average larger diameter of αCaMKII-ir hippocampal neurons.
The results suggested that bilberry fruits exerted a neuroprotective effect on hippocampal neurons in diabetes through its antioxidants activity.
Furthermore, in order to find more information about the bilberry effect on the brain, researchers examined it's anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) neuroprotective effect against retinal damage in vitro and in vivo.
In RGC cultures, VMA and all three anthocyanidins protected the brain against SIN-1 (chloride) toxicity, inhibited lipid peroxidation in mouse forebrain homogenates through the antioxidant property and NMDA-induced morphological retinal damage by allowing high levels of calcium ions (Ca2+) to enter the cells.
Moreover, VMA and all three anthocyanidins also protected the retinal damage by increasing the TUNEL-positive cells in the ganglion cell layer.
Dr. Matsunaga N, the lead scientist said, "VMA and its anthocyanidins have neuroprotective effects (exerted at least in part via an anti-oxidation mechanism) in these in vitro and in vivo models of retinal diseases".
Taken together, bilberry may be considered a functional food for the prevention and treatment of neurological diseases associated with neurotoxicity, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
(3) Environmental Chemicals and Human Neurotoxicity: Magnitude, Prognosis and Markers by Anetor J. I. 1, Anetor G.O. 2, Iyanda AA1 , Adeniyi FAA. (the University of Ibadan)
#Healthyfood #Ginger Derived Exosome-Like Nanovesicles (GDENs) and 6-Shogaol Process Antiemetic and Anticancer Activities, Scientists Say
Kyle J. Norton
Scientists may have found a pungent kitchen spice that processes the potency for the prevention and treatment of cancers, some studies found.
Cancer is a class of chronic illness characterized by cell growth disorderly and uncontrollably in some tissue and organs in the body.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.
Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.
At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.
The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, and family history of cancer are some most common prevalent risk factors of cancer.
Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.
According to the statistic, approximately 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.
Lung, colorectal, breast, and prostate cancer account for about half of all cancer diagnoses and deaths.
About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine obesity and cancer risk.
At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".
These results clearly suggested the risk of cancer is elevated in the obese and overweight population compared to healthy-weight individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
in finding a natural whole food for the treatment of cancer with no side effects, researchers looked into ginger's antiemetic and anticancer activities.
By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-school can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".
Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibiting anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from ginger.
The application of ligands from ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.
These results suggested that ligands on ginger-derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.
Taken together, ginger-processed ligands on ginger-derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Scientists may have found a pungent kitchen spice that processes the potency for the prevention and treatment of cancers, some studies found.
Cancer is a class of chronic illness characterized by cell growth disorderly and uncontrollably in some tissue and organs in the body.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.
Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.
At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.
The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, and family history of cancer are some most common prevalent risk factors of cancer.
Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.
According to the statistic, approximately 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.
Lung, colorectal, breast, and prostate cancer account for about half of all cancer diagnoses and deaths.
About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine obesity and cancer risk.
At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".
These results clearly suggested the risk of cancer is elevated in the obese and overweight population compared to healthy-weight individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
in finding a natural whole food for the treatment of cancer with no side effects, researchers looked into ginger's antiemetic and anticancer activities.
By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-school can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".
Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibiting anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from ginger.
The application of ligands from ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.
These results suggested that ligands on ginger-derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.
Taken together, ginger-processed ligands on ginger-derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)Monday, 31 July 2023
#Herbal #Garlic Extracts Inhibit Pathways Associated with Abnormal Hemostasis and Thrombosis, According to Studies
Kyle J. Norton
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Several sulfur-containing compounds, isolated from garlic may be very effective in the inhibition of platelet aggregation, a recent study suggested.
Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.
According to Ochanomizu University, sulfur-containing compounds in garlic not only inhibited arachidonic acid metabolism but also suppressed aggregation in association with the function of the platelet plasma membrane.
In vitro, garlic mechanisms of action may be comparable to that of the clinically used drug clopidogrel, as the herb exerts antiaggregatory effects. Garlic extracts are acting by inhibiting the ADP pathway, an important physiological agonist of normal hemostasis and thrombosis.
Dr. MacDonald JA lead researcher said, " The ability of an aromatic disulfide to inhibit platelet aggregation can be enhanced by appending an electron-withdrawing group to the aromatic ring. The results presented to establish that the aromatic thiosulfonate is a very effective inhibitor of platelet aggregation"
Besides the sulfur compound, Ajoene, (E, Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide, isolated from alcoholic extracts of garlic reversibly inhibited platelet aggregation through platelet deposition on severely damaged vessel wall but not affected platelet adhesion.
In fact, in the comparison of the effect of the Garlic Pill with Plavix on Platelet Aggregation and Bleeding Time, groups treated with 1200 or 2400 mg garlic inhibited platelet aggregation substantially, through an increased time of bleeding.
The use of garlic supplements should be taken with care for patients who are taking Anticoagulants as garlic may increase risk of bleeding. Also, patients with ulcers should consult with their doctors.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Improving upon the in vitro biological activity of antithrombotic disulfides by MacDonald JA1, Marchand ME, Langler RF. (PubMed)
(2) Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets by Lim H1, Kubota K, Kobayashi A, Seki T, Ariga T.(PubMed)
(3) Antiplatelet activity of Allium ursinum and Allium sativum by Hiyasat B1, Sabha D, Grotzinger K, Kempfert J, Rauwald JW, Mohr FW, Dhein S.(PubMed)
(4) A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel walls in an in vivo porcine experimental model by Apitz-Castro R1, Badimon JJ, Badimon L.(PubMed)
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Several sulfur-containing compounds, isolated from garlic may be very effective in the inhibition of platelet aggregation, a recent study suggested.
Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.
According to Ochanomizu University, sulfur-containing compounds in garlic not only inhibited arachidonic acid metabolism but also suppressed aggregation in association with the function of the platelet plasma membrane.
In vitro, garlic mechanisms of action may be comparable to that of the clinically used drug clopidogrel, as the herb exerts antiaggregatory effects. Garlic extracts are acting by inhibiting the ADP pathway, an important physiological agonist of normal hemostasis and thrombosis.
Dr. MacDonald JA lead researcher said, " The ability of an aromatic disulfide to inhibit platelet aggregation can be enhanced by appending an electron-withdrawing group to the aromatic ring. The results presented to establish that the aromatic thiosulfonate is a very effective inhibitor of platelet aggregation"
Besides the sulfur compound, Ajoene, (E, Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide, isolated from alcoholic extracts of garlic reversibly inhibited platelet aggregation through platelet deposition on severely damaged vessel wall but not affected platelet adhesion.
In fact, in the comparison of the effect of the Garlic Pill with Plavix on Platelet Aggregation and Bleeding Time, groups treated with 1200 or 2400 mg garlic inhibited platelet aggregation substantially, through an increased time of bleeding.
The use of garlic supplements should be taken with care for patients who are taking Anticoagulants as garlic may increase risk of bleeding. Also, patients with ulcers should consult with their doctors.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Improving upon the in vitro biological activity of antithrombotic disulfides by MacDonald JA1, Marchand ME, Langler RF. (PubMed)
(2) Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets by Lim H1, Kubota K, Kobayashi A, Seki T, Ariga T.(PubMed)
(3) Antiplatelet activity of Allium ursinum and Allium sativum by Hiyasat B1, Sabha D, Grotzinger K, Kempfert J, Rauwald JW, Mohr FW, Dhein S.(PubMed)
(4) A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel walls in an in vivo porcine experimental model by Apitz-Castro R1, Badimon JJ, Badimon L.(PubMed)
#Ginger and #Turmeric Mixture Are Associated with the Treatment of RA #Rheumatoid Arthritis Severity and Complications, Researchers Show
Kyle J. Norton
Ginger may have a potential effect on the prevention and treatment of rheumatoid arthritis, some scientists suggested.
Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with the immune system that mistakenly attacks the joint tissue.
According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.
As of today, researchers do not know what triggers the immune system to make antibodies that attack the joint tissue. Why are people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.
However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.
In fact, lifestyle is a preventable risk factor that has been found to elevate the risk of RA in the Western world.
Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.
The Doctor's team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".
And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.
These results indicated a significant change in RA risk just by quitting cigarette smoking.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat rheumatoid arthritis.
Application of Z. officinale extract at doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rats with rheumatoid arthritis.
Continued administration for 26 days of Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critical role in facilitating the onset of low-grade inflammation.
The extract also reduced the immune system in the production of an antibody against the joint tissue.
Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.
Dr. Fouda AM, in the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".
In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine the anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.
Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia.
Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.
Further analysis suggested that the protective effects of GTaq are attributed to increasing food intake and decreasing systemic inflammation and antioxidant activity in the inhibition of oxidative stress.
The finding supported the use of a ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.
However, further data collection large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 andJae Il Shin. (PubMed)
Ginger may have a potential effect on the prevention and treatment of rheumatoid arthritis, some scientists suggested.
Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with the immune system that mistakenly attacks the joint tissue.
According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.
As of today, researchers do not know what triggers the immune system to make antibodies that attack the joint tissue. Why are people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.
However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.
In fact, lifestyle is a preventable risk factor that has been found to elevate the risk of RA in the Western world.
Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.
The Doctor's team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".
And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.
These results indicated a significant change in RA risk just by quitting cigarette smoking.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat rheumatoid arthritis.
Application of Z. officinale extract at doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rats with rheumatoid arthritis.
Continued administration for 26 days of Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critical role in facilitating the onset of low-grade inflammation.
The extract also reduced the immune system in the production of an antibody against the joint tissue.
Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.
Dr. Fouda AM, in the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".
In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine the anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.
Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia.
Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.
Further analysis suggested that the protective effects of GTaq are attributed to increasing food intake and decreasing systemic inflammation and antioxidant activity in the inhibition of oxidative stress.
The finding supported the use of a ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.
However, further data collection large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 andJae Il Shin. (PubMed)
#Avocado Oil Inhibits Parameters Associated with #HighBloodCholesterol, According to Studies
Kyle J. Norton
Avocado may process certain bioactive compounds with the function of inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.
Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membrane walls and stimulating the production of steroid hormones and aiding the digestive tract in absorbing the nutrients for our body needs.
However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque building up on the arterial wall, leading to heart disease and stroke.
Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.
People who follow the Western diet high in saturated and trans fat, red meat, processed food, and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.
According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy, and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".
These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at a lower risk of high blood cholesterol in the future (weeks or months, depending on the levels of blood cholesterol today).
The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).
If your ratio is lower than 4, you are considered to have a healthy blood-cholesterol ratio.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Researchers in the examination of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.
The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.
The rat group treated with additional HAEPA showed a significantly decreased body mass index (BMI), total fat pad mass, and adiposity index, compared to HFD-fed rats.
The LDL and lipid peroxidation levels of the HFD+HAEPA group were significantly lower compared to the HFD group.
Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ, and protein expression of PPAR-γ in mediating the expression of fat-specific genes and in activating the program of adipocyte differentiation was found to be increased in the HFD+HAEPA group than in the HFD group.
The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduces the risk of hyperlipidemia and obesity.
In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion 25 rats were divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.
* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.
* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.
Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".
Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Kkarate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)
Avocado may process certain bioactive compounds with the function of inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.
Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membrane walls and stimulating the production of steroid hormones and aiding the digestive tract in absorbing the nutrients for our body needs.
However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque building up on the arterial wall, leading to heart disease and stroke.
Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.
People who follow the Western diet high in saturated and trans fat, red meat, processed food, and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.
According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy, and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".
These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at a lower risk of high blood cholesterol in the future (weeks or months, depending on the levels of blood cholesterol today).
The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).
If your ratio is lower than 4, you are considered to have a healthy blood-cholesterol ratio.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Researchers in the examination of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.
The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.
The rat group treated with additional HAEPA showed a significantly decreased body mass index (BMI), total fat pad mass, and adiposity index, compared to HFD-fed rats.
The LDL and lipid peroxidation levels of the HFD+HAEPA group were significantly lower compared to the HFD group.
Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ, and protein expression of PPAR-γ in mediating the expression of fat-specific genes and in activating the program of adipocyte differentiation was found to be increased in the HFD+HAEPA group than in the HFD group.
The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduces the risk of hyperlipidemia and obesity.
In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion 25 rats were divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.
* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.
* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.
Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".
Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Kkarate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)
#Bromelain, in the Form of Nanoparticles (NPs) Inhibits the Genes and Proteins Associated with the Risk of Skin Cancer In Vitro
Kyle J. Norton
Skin cancer is a medical condition caused by irregular cell growth in the skin tissues, due to the alternation of cell DNA.
Most cases of skin cancer in the US are associated with prolong-period of sun exposure. In other words, UV rays that damage the skin have been the main culprit that causes the onset of skin cancer.
Believe it or not, according to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.
Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risks of sun and tanning exposure.
Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size, or feel or that bleeds, a small lesion with an irregular border, and portions that appear red, pink, and white, blue or blue-black.
There are 3 major types of skin cancer, including* Basal cell cancer
It is the most common type of skin cancer associated with the abnormal growth of the cells in the lowest layer of the epidermis. Cancer rarely spreads and kills but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.
* Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.
* Melanoma
Melanoma is less common compared to other skin cancer caused by the malignancy of melanocytes, the cell that produced dark pigment for your skin.
Some researchers suggested that by seeking shade, especially between 10 AM and 4 PM. covering yourself with proper sunglasses, clothing, and hat, and using sun protective cream, particularly in avoidance of tanning and UV tanning beds, most types of skin cancer are preventable
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to find a natural ingredient for the treatment of skin cancer, researchers examined the bromelain (BL) effect in the form of nanoparticles (NPs) based delivery systems on skin cancer cells.
The formulated NPs with a mean particle size of 130.4 ± 8.81 nm exhibited sustained release of BL by observation of the analysis.
According to the tested assays, BL-loaded poly (lactic-co-glycolic acid) NPs enhanced anti-tumor effects compared to free BL.
In the tumorigenesis mice model, NPs reduced the average number of tumors by 2.3 folds), delayed tumorigenesis by 2 weeks), and inhibited the percent tumorigenesis by 4 folds.
Furthermore, the administration of NPs also exerted a significant effect on reducing the percent mortality rate and the average tumor volume.
More precisely, NPs demonstrated anti-cancer cell efficacy was attributed to their capability in modulating the expression of pro-apoptotic (P53, Bax) and anti-apoptotic (Bcl2) proteins.
Based on the finding, researchers said, "developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower dosages".
Additionally, in another mouse skin tumorigenesis model, bromelain not only exerted a similar effect to the aforementioned study it also reduced tumor volume up to a tune of approximately 65%.
In this case, bromelain induced cancer cells apoptosis by stimulating the expression of proteins associated with tumor-suppressive and pro-apoptotic genes, inhibiting the gene involved in anti-apoptosis.
Taken together, bromelain may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model by Bhatnagar P1, Pant AB2, Shukla Y2, Chaudhari B2, Kumar P1, Gupta KC. (PubMed)
(2) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway by Bhui K1, Prasad S, George J, Shukla Y. (PubMed)
Skin cancer is a medical condition caused by irregular cell growth in the skin tissues, due to the alternation of cell DNA.
Most cases of skin cancer in the US are associated with prolong-period of sun exposure. In other words, UV rays that damage the skin have been the main culprit that causes the onset of skin cancer.
Believe it or not, according to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.
Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risks of sun and tanning exposure.
Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size, or feel or that bleeds, a small lesion with an irregular border, and portions that appear red, pink, and white, blue or blue-black.
There are 3 major types of skin cancer, including* Basal cell cancer
It is the most common type of skin cancer associated with the abnormal growth of the cells in the lowest layer of the epidermis. Cancer rarely spreads and kills but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.
* Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.
* Melanoma
Melanoma is less common compared to other skin cancer caused by the malignancy of melanocytes, the cell that produced dark pigment for your skin.
Some researchers suggested that by seeking shade, especially between 10 AM and 4 PM. covering yourself with proper sunglasses, clothing, and hat, and using sun protective cream, particularly in avoidance of tanning and UV tanning beds, most types of skin cancer are preventable
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to find a natural ingredient for the treatment of skin cancer, researchers examined the bromelain (BL) effect in the form of nanoparticles (NPs) based delivery systems on skin cancer cells.
The formulated NPs with a mean particle size of 130.4 ± 8.81 nm exhibited sustained release of BL by observation of the analysis.
According to the tested assays, BL-loaded poly (lactic-co-glycolic acid) NPs enhanced anti-tumor effects compared to free BL.
In the tumorigenesis mice model, NPs reduced the average number of tumors by 2.3 folds), delayed tumorigenesis by 2 weeks), and inhibited the percent tumorigenesis by 4 folds.
Furthermore, the administration of NPs also exerted a significant effect on reducing the percent mortality rate and the average tumor volume.
More precisely, NPs demonstrated anti-cancer cell efficacy was attributed to their capability in modulating the expression of pro-apoptotic (P53, Bax) and anti-apoptotic (Bcl2) proteins.
Based on the finding, researchers said, "developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower dosages".
Additionally, in another mouse skin tumorigenesis model, bromelain not only exerted a similar effect to the aforementioned study it also reduced tumor volume up to a tune of approximately 65%.
In this case, bromelain induced cancer cells apoptosis by stimulating the expression of proteins associated with tumor-suppressive and pro-apoptotic genes, inhibiting the gene involved in anti-apoptosis.
Taken together, bromelain may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model by Bhatnagar P1, Pant AB2, Shukla Y2, Chaudhari B2, Kumar P1, Gupta KC. (PubMed)
(2) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway by Bhui K1, Prasad S, George J, Shukla Y. (PubMed)
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