Monday, 31 July 2023

#Lycopene Found in Tomatoes Reduces the Risk of #COPD and Bronchial Asthma (#BA) through Its Antioxidant Activity

Kyle J. Norton

Lung protection is an action in which substances, including herbal remedies, are used to protect the lung against injury or damage.

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.

In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, and smoking are some of the most prevalent factors associated with the onset of the disease.

Most common lung diseases in North America include asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.

Asthma is a medical and chronic condition characterized by the long-term inflammation of the airways of the lungs.

The most common symptoms of asthma are episodes of wheezing, coughing, chest tightness, shortness of breath, reversible airflow obstruction, and bronchospasm.

Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.

Asthma not only interferes with daily activities and also can lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episode and severity of the attacks.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.

Chronic obstructive pulmonary disease (COPD) is a type of lung disease associated with long-term breathing problems and poor airflow, leading to shortness of breath and cough with sputum production.

COPD is a progressive disease and the third leading cause of death in the United States. Chronic obstructive pulmonary disease (COPD), is the third leading cause of death in the US.


Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potential compound for the treatment of asthma researchers examined the effects of ascorbic acid (AA), carotenoids (lutein, zeaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene), retinol and α-tocopherol levels in patients with allergic asthma compared to healthy elderly in Japanese.

Based on the tested analysis, compared to other phytochemicals, plasma AA level was significantly lower in allergic asthma subjects than that in healthy elderly people.

Levels of plasma lycopene and total carotenoid levels and levels of antioxidant enzymes such as GSH content produced by the host were significantly lower in COPD subjects compared to those of healthy elderly people.

However, levels of plasma lycopene and total carotenoid levels showed no effects in the redox markers such as GSSG, and GSH/GSSG ratio associated with the oxidative stress in the lung tissues.

In other words, there is no difference between the redox markers such as GSSG, and GSH/GSSG ratio in both groups.

Furthermore, lycopene and total carotenoid levels did not lower the marker of the levels of urinary 8-OHdG detected between ACOS and BA subjects compared to healthy elderly people.

Increased levels of lycopene and total carotenoid levels in the body do not have a significant impact in reducing the risk of ACOS and BA

Based on the findings, researchers said, "COPD of Japanese patients may develop partly because of oxidative stress derived from a shortage of antioxidant nutrients, especially of AA and lycopene as well as GSH while this may not be the case in both ACOS and BA.".

Taken together, lycopene found in tomatoes may not be considered a remedy for the prevention of overlap syndrome (ACOS) and/or bronchial asthma (BA), pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary lycopene supplementation suppresses Th2 responses and lungeosinophilia in a mouse model of allergic asthma by Hazlewood LC1, Wood LG, Hansbro PM, Foster PS. (PubMed)

#Fermented Korean #SoySauce (KS), and Mixed #SoySauce (MS) Process Strong Antioxidant Activities, Researchers Say

Kyle J. Norton

Antioxidants are stable molecules that inhibit free radicals.
Total antioxidant capacity (TAC) is a measure that assesses the antioxidant status and evaluates the antioxidant response against the free radicals produced in a patient.

Free radicals are unstable atoms with an unpair of electrons on the out ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.

In spite of free radicals harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.
Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.

Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, people with weakened immune system intake of dietary antioxidant or antioxidant supplements may be necessary.

Oxidative stress is a medical condition caused by the unbalanced ratio of the levels of free radicals and antioxidant enzymes produced by the host.

In fact, free radicals exist everywhere including the airs we breathe, the thing we eat and the environment we contact, particularly, cell metabolism in the body.

Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.

On finding a potential plant that processes anti-oxidative stress activity, researchers examined the relationship between in vitro antioxidant capacity of soy sauces and its impact on lipid oxidation in raw and cooked beef patties during 10 days of refrigerated storage.

According to the results of the analysis of 3 commercial soy sauces including industrially fermented soy sauce (IS), traditionally fermented Korean soy sauce (KS), and mixed soy sauce (MS),
* In vitro antioxidant capacity, KS showed the highest total phenol content, whereas IS and MS had a higher Fe2+ chelating activity than KS (P < .05).

* Heat treatment decreased total phenol content but increased Fe2+ chelating activity of soy sauces (P < .001).

* In both raw and cooked beef patties, the addition of IS or MS caused a lower 2-thiobarbituric acid reactive substances (TBARS) level than KS throughout the overall storage period (P < .05).

Collectively, researchers suggest, "the Fe2+ chelating activity of soy sauce may be one of the major mechanisms in preventing lipid oxidation in meat products".

Taken altogether, potato may be considered a functional food for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Relationship between the antioxidant capacity of soy sauces and its impact on lipid oxidation of beef patties by Ham YK1, Hwang KE2, Song DH3, Choi JH2, Choi YS4, Kim HW. (PubMed)

#Omega3 Fatty Acids Process Anti Anxiolytic Effect, According to Studies

Kyle J. Norton

Anxiety is a psychological and physiological state triggered by feelings of fear, worry, uneasiness, dread, etc.
The condition is a normal reaction to stress that allows a person to cope with the situation during an emotionally difficult time. But when anxiety symptoms escalate or become excessive, it can lead to anxiety disorder.

People experience anxiety differently. Some people feel a sudden moment of anxiety just a bad feeling, it comes and goes, only lasting a short time. Depending on how people cope with moments of anxiety, the events can be brief or last a few days.

However, in some persons, if anxiety does not go away, they may require treatment from related field specialists.

Some researchers suggested that anxiety disorders are conditions associated with the combination of biological, psychological, and individual factors, and the most commonly reported psychiatric conditions frequently occur as comorbid disorders.

According to the statistic, anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the age of 18 and older, or 18.1% of the population every year.

The exact causes of anxiety disorders are debatable. However, a family history of anxiety recent or prolonged exposure to stress, and excessive consumption of stimulants such as caffeine or tobacco is associated with the onset of the disorders.

The symptoms of anxiety disorders can be psychological or physical, including difficulty concentrating and sleeping, irritability, persistent stomachaches or diarrhea, sweaty palms, shaking, and rapid heartbeat.

Other patients may also experience frequent nervousness, restlessness, or being tense feelings of danger, panic, dread rapid heart rate rapid breathing, or hyperventilation,..... you may have developed an anxiety disorder.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the treatment of psychological disorders, researchers investigated the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) for anxiety symptoms compared with controls.

The study included the research of clinical trials involved in the anxiolytic effect of omega-3 PUFAs in humans, in either placebo-controlled or non-placebo-controlled designs found 104 selected articles with 19 entered the final data extraction stage.

Based on the differentiation of the selected articles including 1203 participants with omega-3 PUFA treatment (mean age, 43.7 years; mean female proportion, 55.0%; mean omega-3 PUFA dosage, 1605.7 mg/d) and 1037 participants without omega-3 PUFA treatment (mean age, 40.6 years; mean female proportion, 55.0%), the researchers found that
* The administration of omega-3 fatty acid showed an association between clinical anxiety symptoms among participants with omega-3 PUFA treatment compared with control arms (Hedges g, 0.374; 95% CI, 0.081-0.666; P = .01).

* Furthermore, in subgroup analysis, injection of Omega 3 fatty acid showed that the association of treatment with reduced anxiety symptoms was significantly greater in subgroups with specific clinical diagnoses than in subgroups without clinical conditions.

* Moreover, The anxiolytic effect of omega-3 PUFAs was significantly better than that of controls only in subgroups with a higher dosage (at least 2000 mg/d) and not in subgroups with a lower dosage (<2000 mg/d).

In other words, omega-3 fatty acid has a strong implication in reducing anxiety symptoms in a dose-dependent manner.


Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of anxiety, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis by Su KP1,2,3, Tseng PT4, Lin PY5,6,7, Okubo R8, Chen TY9,10,11, Chen YW12, Matsuoka YJ. (PubMed)
(2) A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent-onset psychosis: Results from a 16-week randomized placebo-controlled trial for participants concurrently treated with risperidone by Robinson DG1, Gallego JA2, John M3, Hanna LA4, Zhang JP2, Birnbaum ML2, Greenberg J4, Naraine M4, Peters BD4, McNamara RK5, Malhotra AK2, Szeszko PR. (PubMed)

#Potatoes Inversely Are Associated with A Reduced Risk of Obesity, Type 2 Diabetes, and CardiovascularDisease #CVD

Kyle J. Norton

Chronic diseases are medical conditions that last more than 3 months depending on the type of diseases.
In other words, chronic diseases generally cannot be prevented or cured by medication, nor do they just disappear.

According to the statistics, chronic diseases affect millions of people worldwide, leading to the death of 35 million people in 2005, including many young people and those in middle age.

The most common types of chronic diseases in the Western world are cardiovascular diseases and diabetes.

Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.

Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.

The most common symptoms of type 2 diabetes are an increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.

Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

Potato is the genus Solanum and belongs to the family Solanaceae. The veggie is a good source of protein and according to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potato. It now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.

In finding a potential plant for the prevention and treatment of chronic diseases, researchers evaluated the relation between intake of potatoes and risks of obesity, T2D, and CVD in apparently healthy adults.

According to the search of the databases of MEDLINE, Embase, the Web of Science, and the Cochrane Central Register of Controlled Trials involved in the intervention and prospective observational studies identified a total of 13 studies, including 5 studies that were related to obesity, 7 studies that were related to T2D, and one study that was related to CVD,* The association between potatoes (not including french fries) and adiposity was neutral in 2 studies and was positive in 2 studies.

* For T2D, 2 studies showed a positive association, whereas 5 studies showed no or a negative association with intake of potatoes and T2D.

* For CVD, no association was observed.

Most importantly, French fries were positively associated with T2D and obesity in all studies.

Collectively, researchers said, "The identified studies do not provide convincing evidence to suggest an association between intake of potatoes and risks of obesity, T2D, or CVD"

And, "French fries may be associated with increased risks of obesity and T2D".


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potatoes and risk of obesity, type 2 diabetes, and cardiovascular disease in apparently healthy adults: a systematic review of clinical intervention and observational studies by Borch D1, Juul-Hindsgaul N1, Veller M1, Astrup A1, Jaskolowski J1, Raben A. (PubMed)

The #Herbal #Ashwagandha #RootPowders Effect on Reducing Lipid Profiles in Vivos, Researchers Say

Kyle J. Norton

Cholesterol, a waxy substance produced by the liver or the dietary plays a critical role to aid digestive function in absorbing nutrients and fluids, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts of cholesterol in the blood have been found to induce plaque built-up on the arterial wall, leading to hypercholesterolemia, a leading cause of heart disease, and stroke.

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

The condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).

People with hypercholesterolemia at the early stage are asymptomatic. However, patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US.

In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people with hypercholesterolemia are getting treatment.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the treatment of high blood cholesterol, researchers examined the ashwagandha root extract's anti-hypercholesteremic effects in an animal model.

Selected hypercholesteremic male albino rats were given root powder of WS added to the diet at 0.75 and 1.5 gm/rat/day.

During the experiment, researchers found that the root powder of WS showed a strong anti-hypercholesteremic activity by significantly decreasing levels of total lipids, cholesterol, and triglycerides, in blood plasma.

Furthermore, WS also reduced the levels of cholesterol by significantly increasing plasma HDL-cholesterol levels, HMG-CoA reductase activity, and bile acid content of the liver.

Moreover, lipid-peroxidation associated with liver stress was inhibited by WS administration in hypercholesteremic animals, compared to other normal counterparts.

Based on the findings, researchers said, "It appeared that WS root powder is also effective in normal subjects for decreasing lipid profiles".

Taken together, Ashwagandha may be considered a functional herb for the treatment of hypercholesterolemia, pending the result of a larger sample size and multicenter study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypocholesterolemic and antioxidant effects of Withania somnifera (Dunal) in hypercholesteremic rats by Visavadiya NP1, Narasimhacharya AV. (PubMed)

The Effects of #Herbal #Chastetreeberry on #Estrogenic Receptors, According to Studies

Kyle J. Norton


Chaste tree berry processes both estrogenic and anti-estrogenic properties and may be considered a functional food for women with delayed aging progression, restored hormone balance in ameliorated menstrual disorders, alleviated menopausal symptoms, and more........

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.


Estrogenic Property
Chaste tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.

According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.

Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that besides linoleic acid, flavones derivative vitexin and Pendleton. isolated from Vitex agnus-castus (VAC) also expressed the estrogenic effect as the most active ERss-selective phytoestrogens.

Anti-estrogen Property
Chaste tree berry(Vitex agnus-castus), also processes anti-estrogenic properties in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.

Anti-estrogenic effects are an act of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulating in the body.

According to the University of Alabama in Huntsville, in the study of the potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.

Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed an anti-estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti-estrogenic effect.

In hyperprolactinemia (MIHP) induced by the administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, application of casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L) inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.

More importantly, oral administration of casticin, a flavonoid isolated from Vitex rotundifolia displayed an anti-estrogenic activity in decreasing excessive levels of 17β-Estradiol (E2) significantly

Summary
Chaste tree berry(Vitex agnus-castus) exerts estrogenic components of plant extracts that may constitute a potential use for some dietary supplements in humans for the treatment of various estrogen-related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration and anti-estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER-alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.

In other words, chaste tree berries stimulated estrogen receptors in the release of estrogen into the blood in case of deficiency or inhibited extra levels of estrogen in case of excess maintenance hormone balancing with other sex hormones.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Sources

(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. (PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
(5) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(6) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)

MK615, an Extract Mixture of #Hydrophobic Substances from Japanese Apricot Process Anti-#BreastCancer Activity, Scientists Say

Kyle J. Norton

Finding a cure for breast cancer from botanical plants without inducing side effects has been a lifetime dream of many scientists. Unfortunately, as of today, the finding is still ongoing without much success.
However, according to some studies, apricot, the edible fruit may be the next pharmaceutical target to extract potential ingredients for the cure for breast cancer.

Breast cancer is a medical and chronic condition as the result of irregular cell growth originating from the breast tissue. why women in the same health conditions, family history, and race, some are prone to develop the early onset of the disease while others do not.

Breast cancer is caused by the alternation of DNA of the cells in the breast tissue. Epidemiologically, certain prevalent factors are associated with an increased risk of the disease.

According to the probability for women to develop or die from breast cancer provided by the Canadian Cancer Statistics publication, the lifetime risk of a woman to develop is 1/8 and 1/31 of them will die from the disease.

The 5 years survival rate of the early stage of breast cancer is 100% compared to much less in the advanced stage.

Therefore, women with higher risk such as genetic preposition of genes BRAC1 and 2 should have their breast mammogram taken every year.


More importantly, Dr. Zainab Taha, the lead author in the study "The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East" wrote,
"There is an alarming epidemic of obesity among women in most of the EMR countries, especially Gulf Coopers Action Council (GCC) countries. The rise in the new breast cancer cases among women could be attributed to excess body weight. Their dietary pattern, which correlates with obesity, can be an important factor in the etiology of cancer.".

These results strongly suggested that diet and lifestyle associated with the onset of obesity are major contributors to the early onset of breast cancer.

In other words, if you follow a healthy diet with a lot of fruits and vegetables, whole grains with less in saturated and trans fat, red meat, and processed and a lifestyle with moderate exercise, you are at the lower end of the risk factor scale of breast cancer.

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae. Apricot is classified with the family of plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

In the reaffirming of the MK615, an extract mixture containing hydrophobic substances from Japanese apricot. anti-cancer possibility, researchers at the Dokkyo University School of Medicine conducted an evaluation to examine the antineoplastic effects of MK615 against breast cancer cells.
The experiment includes 2 breast cancer cell lines, MDA-MB-468 (MDA) and MCF7, was cultured with (600, 300, and 150 mg/mL) or without MK615.

After 72 hours of incubation, researchers showed that

* MK615 inhibited the growth of MDA and MCF7 in a dose-dependent manner.

* The percentage growth inhibition of MDA at dosages of 600, 300, and 150 mg/mL was 59.2%, 52.4%, and 23.3%, respectively, and that for MCF7 was 83.5%, 52.7%, and 16.6%, respectively.

* MK615 treatment included massive vacuolization in the cytoplasm and apoptotic changes in the nucleus.

* Cell cycle analysis showed that MK615 increased the proportion of cells in the G2-M phase in both MDA (7.8-11.7%) and MCF7 (8.1-18.7%), and finally both cell lines became apoptotic.

These results suggested MK615 effectively inhibits the growth of breast cancer cells in vitro, through cell cycle arrest and apoptosis.


Furthermore, in the concerns of breast cancer continued to cause high cancer death rates among women worldwide, researchers at the joint study led by the Universiti Sains Malaysia launched an evaluation to examine the plant-based products which have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth.

Out of the medical plants selected including Glycyrrhiza glabra, Uncaria tomentosa, Camellia sinensis, Panax ginseng, Prunus armenaica (apricot), Allium sativum, Arctium lappa and Curcuma longa, malic acid and quinic acid isolated from apricot exerted a significant activity in regulating the immune system potentially applicable in breast cancer treatment via anti-inflammatory and lymphocytes activation.


Taken together, apricot may be considered a functional food for the prevention and a secondary therapy combined with conventional medicine for the treatment of breast cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) [Studies on the chemical constituents of flowers of Prunus mume].[Article in Chinese] by Zhang QH1, Zhang L, Shang LX, Shao CL, Wu YX.(PubMed)
(1) New antineoplastic agent, MK615, from UME (a Variety of) Japanese apricot inhibits the growth of breast cancer cells in vitro by Nakagawa A1, Sawada T, Okada T, Ohsawa T, Adachi M, Kubota K. (PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS. (PubMed)
(3) The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East by Zainab Taha1 and Sakina E. Eltom. (PMC)