Kyle J. norton
The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).
Acetylcholinesterase (AChE) is the primary enzyme that hydrolyzes the neurotransmitter acetylcholine to choline and acetate.
Altered levels of ACh in the nervous system have been found to induce several neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington, depending on the affected areas.
Butyrylcholinesterase (BuChE) enzyme plays a minor role in regulating brain acetylcholine (ACh) levels.
A cholinergic neuron is a nerve cell that mainly is used by the neurotransmitter acetylcholine (ACh) to send its messages
Impairment of the cholinergic neuronal system in the brain was involved in the underlying event of cognitive impairment.
Cholinesterase inhibitors (ChEI) have been used for the treatment of Alzheimer's disease (AD).
Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as an anti-spasmodic, anti-inflammatory, and nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with menopause, etc.
In finding a potential herbal medicine for the prevention and treatment of associated neurodegenerative diseases, researchers examined ethyl acetate, methanol, and water extracts prepared from the branches, leaves, and fruits of Viburnum opulus and Viburnum lantana along with salicin on acetylcholinesterase (AChE) inhibitory and antioxidant activities.
In vitro, according to the results from an enzyme-linked immunosorbent assay, the leaf methanol extract of V. opulus displayed a significantly high inhibitory effect against AChE at 50, 100, and 200 μL/mL concentrations of 57.63%, 87%, and 93%, respectively compared to other extracts.
In other words, the leaf methanol extract of V. opulus showed the highest protective activity against the disruption of neurons in the induction of neurodegenerative diseases linearly in a doses dependent-manner.
Compared to Viburnum opulus, the extracts of V. lantana exerted higher antioxidant activity.
Taken altogether, cramp bark(Viburnum opulus) leaves may be considered a functional acetylcholinesterase inhibitor herb medicine for the prevention and treatment of neurodegenerative diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents by Erdogan-Orhan I1, Altun ML, Sever-Yilmaz B, Saltan G. (PubMed)
Thursday, 27 July 2023
#Honey Inhibits Chemo-toxicity and Enhances Chemo-Drugs Activities Against #Cancers, Researchers Show
Kyle J. Norton
Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.
Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.
Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.
However, as cancer progresses, the continued growth of the tumor may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.
At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.
According to the statistic from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.
In 2017, over 15,000 children and adolescents ages, 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.
Chemo drugs are medicine used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organ.
Chemotoxicity is the side effect of chemo drugs.
The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.
According to the information from the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.
The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick, and being easily infected.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener.
In finding a natural ingredient or whole food which processes chemopreventive properties and anti-chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.
A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.
AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage to liver and kidney
After treatment of KH, the AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by the blood profile.
Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.
These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs' activity without inducing any side effects.
Moreover, on finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.
Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function of stimulating cancer cell multicity and activation of pathways associated with cell death programming.
Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing harm to the nearby cells and tissue.
This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.
Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.
The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting toxicity and cancer cell resistance.
Taken altogether, KH and MH can be considered functional foods for the prevention and adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)
Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.
Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.
Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.
However, as cancer progresses, the continued growth of the tumor may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.
At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.
According to the statistic from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.
In 2017, over 15,000 children and adolescents ages, 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.
Chemo drugs are medicine used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organ.
Chemotoxicity is the side effect of chemo drugs.
The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.
According to the information from the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.
The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick, and being easily infected.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener.
In finding a natural ingredient or whole food which processes chemopreventive properties and anti-chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.
A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.
AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage to liver and kidney
After treatment of KH, the AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by the blood profile.
Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.
These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs' activity without inducing any side effects.
Moreover, on finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.
Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function of stimulating cancer cell multicity and activation of pathways associated with cell death programming.
Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing harm to the nearby cells and tissue.
This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.
Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.
The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting toxicity and cancer cell resistance.
Taken altogether, KH and MH can be considered functional foods for the prevention and adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)
#Sulfur and #Organic compounds From #Leeks Induce Cancer Cell Apoptosis, According to Studies
Kyle J. Norton
Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells' growth and proliferation.
Cancers are the second leading cause of death worldwide besides heart diseases.
The most common types of cancer in Canada include lung, colorectal, breast, and prostate cancers. And these 4 cancers account for half of all cancers diagnosed in Canada.
Leek is a genius of Allium, belonging to the vegetable family vegetable Alliacaea, the same as onion and garlic. Leeks are easy to grow from seed and usually reach maturity in the autumn months, and have few pest or disease problems.
In finding a potential plant that processes anti-tumor growth activity researchers compared the anticancer properties of various sulfur and organic compounds like S-allyl mercaptocysteine, quercetin, flavonoids, and ajoene on cancer.
According to the analysis,
* These compounds with various mechanisms such as hindering the cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells.
* Similar to garlic and onion, other species such as leeks have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents.
Collectively, researchers said, "In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further research on the treatment and prevention of cancers".
Taken together, leeks may be considered a functional food for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allium vegetables for possible future of cancer treatment by Asemani Y1, Zamani N2, Bayat M1, Amirghofran Z. (PubMed)
Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells' growth and proliferation.
Cancers are the second leading cause of death worldwide besides heart diseases.
The most common types of cancer in Canada include lung, colorectal, breast, and prostate cancers. And these 4 cancers account for half of all cancers diagnosed in Canada.
Leek is a genius of Allium, belonging to the vegetable family vegetable Alliacaea, the same as onion and garlic. Leeks are easy to grow from seed and usually reach maturity in the autumn months, and have few pest or disease problems.
In finding a potential plant that processes anti-tumor growth activity researchers compared the anticancer properties of various sulfur and organic compounds like S-allyl mercaptocysteine, quercetin, flavonoids, and ajoene on cancer.
According to the analysis,
* These compounds with various mechanisms such as hindering the cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells.
* Similar to garlic and onion, other species such as leeks have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents.
Collectively, researchers said, "In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further research on the treatment and prevention of cancers".
Taken together, leeks may be considered a functional food for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allium vegetables for possible future of cancer treatment by Asemani Y1, Zamani N2, Bayat M1, Amirghofran Z. (PubMed)
#Solasodine Found in #Eggplant Decreases Rxpression of MicroRNA Associated with an Increased Risk of #LungCancer
Kyle J. Norton
Eggplant may have a potential and substantial effect in reduced risk and treatment of lung cancer, some scientists suggested.
Eggplant is a species of S. melongena with deep purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, approximately 28,600 Canadians will be diagnosed with lung cancer representing 14% of all new cancer cases in 2017.
In the investigation of the eggplant bioactive phytochemical glycoalkaloids activity and risk of various types of malignant tumors, Dr. Friedman M found that derivatives of glycoalkaloids, α-solamargine, and α-solasonine demonstrated a strongly inhibited effect in the growth of the lung and other cancer cells in culture (in vitro) as well as tumor growth in vivo, involved some unknown signaling pathways.
More specifically, the investigation of solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant (Solanum melongena) in human lung cancer cell line A549 showed that solasodine displays a significant effect in ameliorated cancer cell viability and initiated cell apoptosis through attenuating expression of mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 which were found to be elevated in patients with lung cancer in compared to healthy subjects and extracellular inducer of matrix metalloproteinase (EMMPRIN), a cell surface glycoprotein which plays an important role in stimulated the production of several matrix metalloproteinases (MMPs).
Further differentiation, also indicated that the inhibitory property of solasodine by increased expression of a reversion-inducing cysteine-rich protein with Kazal motifs (RECK) not only reduces the risk of RECK accelerated cancer cell proliferation but also exhibits initiation of irreversible growth cycle arrest through short hairpin of mRNA in the suppression of the RECK gene.
Additionally, injection of solasodine promoted cancer cells death and was also associated with the overexpression of tissue inhibitor of metalloproteinase-1 (TIMP-1), a glycoprotein found in several tissues of organisms with function involved in the degradation of the extracellular matrix as mentioned above and TIMP-2, a member of the TIMP gene family with function as a metastasis suppressor.
According to the immunoblotting assays, the administration of solasodine is very effective in suppressing PI3K /Akt phosphorylation of lung cancer cells in the induction of cell proliferation.
PI3K /Akt phosphorylation plays critical roles in the regulation of many cellular processes including cell cycle, growth, apoptosis, and signal transduction pathways.
Alterations in phosphorylation pathways result in serious outcomes in the form of diseases, especially cancer.
Finally, solasodine decreased expression of microRNA-21 which has been found to be higher in more advanced malignancies, in initiated early entry phase of cancer developing by stimulated production of RECK in accelerated cancer cell proliferation, thus decreasing the risk of cell invasion.
After taking into account all confounders, Dr. Shen KH, the lead author said, "The findings demonstrate an attractive therapeutic potential for solasodine in lung cancer anti-metastatic therapy".
Taken together, eggplant with abundant phytochemicals may be considered a functional food for attenuated risk and used in combination with standard medicine for the treatment of lung cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Solasodine inhibits invasion of human lung cancer cells through downregulation of miR-21 and MMPs expression by Shen KH1, Hung JH2, Chang CW2, Weng YT2, Wu MJ2, Chen PS3. (PubMed)
(2) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1. (PubMed)
Eggplant may have a potential and substantial effect in reduced risk and treatment of lung cancer, some scientists suggested.
Eggplant is a species of S. melongena with deep purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, approximately 28,600 Canadians will be diagnosed with lung cancer representing 14% of all new cancer cases in 2017.
In the investigation of the eggplant bioactive phytochemical glycoalkaloids activity and risk of various types of malignant tumors, Dr. Friedman M found that derivatives of glycoalkaloids, α-solamargine, and α-solasonine demonstrated a strongly inhibited effect in the growth of the lung and other cancer cells in culture (in vitro) as well as tumor growth in vivo, involved some unknown signaling pathways.
More specifically, the investigation of solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant (Solanum melongena) in human lung cancer cell line A549 showed that solasodine displays a significant effect in ameliorated cancer cell viability and initiated cell apoptosis through attenuating expression of mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 which were found to be elevated in patients with lung cancer in compared to healthy subjects and extracellular inducer of matrix metalloproteinase (EMMPRIN), a cell surface glycoprotein which plays an important role in stimulated the production of several matrix metalloproteinases (MMPs).
Further differentiation, also indicated that the inhibitory property of solasodine by increased expression of a reversion-inducing cysteine-rich protein with Kazal motifs (RECK) not only reduces the risk of RECK accelerated cancer cell proliferation but also exhibits initiation of irreversible growth cycle arrest through short hairpin of mRNA in the suppression of the RECK gene.
Additionally, injection of solasodine promoted cancer cells death and was also associated with the overexpression of tissue inhibitor of metalloproteinase-1 (TIMP-1), a glycoprotein found in several tissues of organisms with function involved in the degradation of the extracellular matrix as mentioned above and TIMP-2, a member of the TIMP gene family with function as a metastasis suppressor.
According to the immunoblotting assays, the administration of solasodine is very effective in suppressing PI3K /Akt phosphorylation of lung cancer cells in the induction of cell proliferation.
PI3K /Akt phosphorylation plays critical roles in the regulation of many cellular processes including cell cycle, growth, apoptosis, and signal transduction pathways.
Alterations in phosphorylation pathways result in serious outcomes in the form of diseases, especially cancer.
Finally, solasodine decreased expression of microRNA-21 which has been found to be higher in more advanced malignancies, in initiated early entry phase of cancer developing by stimulated production of RECK in accelerated cancer cell proliferation, thus decreasing the risk of cell invasion.
After taking into account all confounders, Dr. Shen KH, the lead author said, "The findings demonstrate an attractive therapeutic potential for solasodine in lung cancer anti-metastatic therapy".
Taken together, eggplant with abundant phytochemicals may be considered a functional food for attenuated risk and used in combination with standard medicine for the treatment of lung cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Solasodine inhibits invasion of human lung cancer cells through downregulation of miR-21 and MMPs expression by Shen KH1, Hung JH2, Chang CW2, Weng YT2, Wu MJ2, Chen PS3. (PubMed)
(2) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1. (PubMed)
#OleanolicAcid as a Triterpenoid Processes Anti-Inflammatory and Anti-Apoptotic Properties, According to Studies
Kyle J. Norton
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
Acute inflammation occurs quickly or within hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.
However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.
Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.
Any inflammation that lasts more than 8 weeks is considered chronic inflammation.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Anti-inflammation is a process that inhibits the pro-inflammatory cytokines without affecting the immune system's activity against pathogens.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.
Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.
In finding a potential plant in the prevention and treatment of chronic diseases, researchers examined the effect of Oleanolic acid (OA), as a triterpenoid, has anti-oxidant, anti-inflammatory, and anti-apoptotic activities on motor function in Spinal cord injury (SCI) mice.
According to the results of the analysis,
* OA in a dose-dependent manner up-regulated the spinal cords of SCI mice and improved the blood-spinal cord barrier.
* OA treatments significantly reduced apoptotic cell death in spinal cord samples of SCI mice by decreasing the expression of pro-apoptotic cleaved Caspase-3.
* Furthermore, OA significantly attenuated the pro-inflammatory response in SCI mice.
* Most importantly, SCI mice exhibited higher activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) signaling pathways involved in cell death but these effects were clearly blocked in SCI mice with OA treatments.
In other words, in vivo, OA exerted protective effects against SCI induced by lipopolysaccharide (LPS)-stimulated mouse neurons mainly through the suppression of apoptosis and inflammatory response.
Taken altogether, Oleanolic acid may be considered a remedy that processes inflammatory and apoptotic activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs by Wang JL1, Ren CH1, Feng J2, Ou CH3, Liu L4. (PubMed)
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
Acute inflammation occurs quickly or within hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.
However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.
Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.
Any inflammation that lasts more than 8 weeks is considered chronic inflammation.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Anti-inflammation is a process that inhibits the pro-inflammatory cytokines without affecting the immune system's activity against pathogens.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.
Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.
In finding a potential plant in the prevention and treatment of chronic diseases, researchers examined the effect of Oleanolic acid (OA), as a triterpenoid, has anti-oxidant, anti-inflammatory, and anti-apoptotic activities on motor function in Spinal cord injury (SCI) mice.
According to the results of the analysis,
* OA in a dose-dependent manner up-regulated the spinal cords of SCI mice and improved the blood-spinal cord barrier.
* OA treatments significantly reduced apoptotic cell death in spinal cord samples of SCI mice by decreasing the expression of pro-apoptotic cleaved Caspase-3.
* Furthermore, OA significantly attenuated the pro-inflammatory response in SCI mice.
* Most importantly, SCI mice exhibited higher activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) signaling pathways involved in cell death but these effects were clearly blocked in SCI mice with OA treatments.
In other words, in vivo, OA exerted protective effects against SCI induced by lipopolysaccharide (LPS)-stimulated mouse neurons mainly through the suppression of apoptosis and inflammatory response.
Taken altogether, Oleanolic acid may be considered a remedy that processes inflammatory and apoptotic activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs by Wang JL1, Ren CH1, Feng J2, Ou CH3, Liu L4. (PubMed)
#Cabbage Microgreens Lowers Circulating LDL Levels and Reduces Liver Cholesterol Ester, Researchers Say
Kyle J. Norton
Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.
The condition is normally known as high blood cholesterol in the general population.
People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances forms plaque, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults aged 20 and
High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.
Believe it or not, only half of the people with high blood cholesterol benefit from taking the lowering blood cholesterol medicine.
Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, and produces vitamin D and steroid hormones.
Believe it or not, about half of U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol.
There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, overweight gain, physical activity, and smoking.
Some researchers suggested the promotion of a high-fat diet over the past decades may be one of the silent causes of hyperlipidemia in the Western world.
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In findings a natural whole for the treatment of cardiovascular disease (CVD), researchers examined the effectiveness of microgreens in affecting lipid and cholesterol levels.
The study included C57BL/6NCr mice (n = 60, male, 5 weeks old) induced obesity (DIO) model were randomly assigned to six feeding groups: (1) low-fat diet; (2) high-fat diet; (3) low-fat diet + 1.09% red cabbage microgreens; (4) low-fat diet + 1.66% mature red cabbage; (5) high-fat diet + 1.09% red cabbage microgreens; (6) high-fat diet + 1.66% mature red cabbage for 8 weeks.
According to the results of the differentiation
* Microgreen supplementation attenuated high-fat diet-induced weight gain.
* Furthermore, supplementation with microgreens significantly lowered circulating LDL levels in animals fed the high-fat diet and reduced hepatic cholesterol ester.
* Moreover, the levels of triacylglycerol levels and expression of inflammatory cytokines in the liver were also inhibited by dietary microgreens.
Based on the findings, researchers suggested that microgreens can modulate weight gain and cholesterol metabolism and may protect against CVD by preventing hyperlipidemia.
Taken altogether, cabbage processes anti-hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the KIarate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet by Huang H1,2, Jiang X2, Xiao Z3,4, Yu L2, Pham Q1, Sun J5, Chen P5, Yokoyama W6, Yu LL2, Luo YS3, Wang TT. (PubMed)
Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.
The condition is normally known as high blood cholesterol in the general population.
People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances forms plaque, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults aged 20 and
High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.
Believe it or not, only half of the people with high blood cholesterol benefit from taking the lowering blood cholesterol medicine.
Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, and produces vitamin D and steroid hormones.
Believe it or not, about half of U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol.
There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, overweight gain, physical activity, and smoking.
Some researchers suggested the promotion of a high-fat diet over the past decades may be one of the silent causes of hyperlipidemia in the Western world.
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In findings a natural whole for the treatment of cardiovascular disease (CVD), researchers examined the effectiveness of microgreens in affecting lipid and cholesterol levels.
The study included C57BL/6NCr mice (n = 60, male, 5 weeks old) induced obesity (DIO) model were randomly assigned to six feeding groups: (1) low-fat diet; (2) high-fat diet; (3) low-fat diet + 1.09% red cabbage microgreens; (4) low-fat diet + 1.66% mature red cabbage; (5) high-fat diet + 1.09% red cabbage microgreens; (6) high-fat diet + 1.66% mature red cabbage for 8 weeks.
According to the results of the differentiation
* Microgreen supplementation attenuated high-fat diet-induced weight gain.
* Furthermore, supplementation with microgreens significantly lowered circulating LDL levels in animals fed the high-fat diet and reduced hepatic cholesterol ester.
* Moreover, the levels of triacylglycerol levels and expression of inflammatory cytokines in the liver were also inhibited by dietary microgreens.
Based on the findings, researchers suggested that microgreens can modulate weight gain and cholesterol metabolism and may protect against CVD by preventing hyperlipidemia.
Taken altogether, cabbage processes anti-hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the KIarate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet by Huang H1,2, Jiang X2, Xiao Z3,4, Yu L2, Pham Q1, Sun J5, Chen P5, Yokoyama W6, Yu LL2, Luo YS3, Wang TT. (PubMed)
#UrsolicAcid Processes Anti-inflammatory, Induced Apoptotic and Anti-Proliferative Activities Against #BreastCancer, Researchers Say
Kyle J. Norton
Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, most cases of breast cancer start in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage, breast cancer cells caused by the alternation of DNA can travel far away from the primary site to infect other healthy tissue and organs.
Most patients the early may have a lump when touching with no symptoms.
However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Genetic preposition, one of the prevalent risk factors associated with the increased risk of breast cancer has been under intensifying study by scientists around the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.
Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.
The 5 years of survival rate of localized breast cancer are close to 100%.
The risk factors of breast cancer can be divided into 2 groups
* Preventable risk factors include exposure to ionizing radiation, hormone replacement therapy, use of oral contraceptives, alcohol, being obese and physical inactivity.
* Unpreventable risk factors include family and personal history, age, race, genetic preposition, dense breast, and reproductive history.
If you are at a higher risk of breast cancer, please make sure your self check your breast every month for preventive measures.
Since breast cancer is so sensitive to levels of hormones, some scientists suggested that hormonal changes may have a critical impact on the disease.
Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.
On finding a potential phytochemical for the treatment of chronic diseases, researchers examined ursolic acid, a naturally synthesized pentacyclic triterpenoid, widely distributed in different fruits and vegetables' anti-breast cancer properties.
According to the analysis,
* Ursolic acid and its derivatives exhibited anticancer activity, anti-inflammatory effects, and induction of apoptosis in several human cancer cells.
* Furthermore, ursolic acid inhibited breast cancer proliferation by inducing cell G1/G2 arrest.
* Moreover, ursolic acid regulated the expression of key proteins in signal transduction pathways against the promotion of breast cancer.
* Additionally, ursolic acid-induced apoptosis in human breast cancer cells through intrinsic and extrinsic apoptotic pathways.
* Ursolic acid scavenged free radicals and p[rocesses a potent anti-inflammation activity.
Taken altogether, Ursolic acid may be considered adjunct therapy in the treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ursolic acid, a potential anticancer compound for breast cancer therapy by Yin R1, Li T1, Tian JX1, Xi P1, Liu RH. (PubMed)
Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, most cases of breast cancer start in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage, breast cancer cells caused by the alternation of DNA can travel far away from the primary site to infect other healthy tissue and organs.
Most patients the early may have a lump when touching with no symptoms.
However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Genetic preposition, one of the prevalent risk factors associated with the increased risk of breast cancer has been under intensifying study by scientists around the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.
Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.
The 5 years of survival rate of localized breast cancer are close to 100%.
The risk factors of breast cancer can be divided into 2 groups
* Preventable risk factors include exposure to ionizing radiation, hormone replacement therapy, use of oral contraceptives, alcohol, being obese and physical inactivity.
* Unpreventable risk factors include family and personal history, age, race, genetic preposition, dense breast, and reproductive history.
If you are at a higher risk of breast cancer, please make sure your self check your breast every month for preventive measures.
Since breast cancer is so sensitive to levels of hormones, some scientists suggested that hormonal changes may have a critical impact on the disease.
Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.
On finding a potential phytochemical for the treatment of chronic diseases, researchers examined ursolic acid, a naturally synthesized pentacyclic triterpenoid, widely distributed in different fruits and vegetables' anti-breast cancer properties.
According to the analysis,
* Ursolic acid and its derivatives exhibited anticancer activity, anti-inflammatory effects, and induction of apoptosis in several human cancer cells.
* Furthermore, ursolic acid inhibited breast cancer proliferation by inducing cell G1/G2 arrest.
* Moreover, ursolic acid regulated the expression of key proteins in signal transduction pathways against the promotion of breast cancer.
* Additionally, ursolic acid-induced apoptosis in human breast cancer cells through intrinsic and extrinsic apoptotic pathways.
* Ursolic acid scavenged free radicals and p[rocesses a potent anti-inflammation activity.
Taken altogether, Ursolic acid may be considered adjunct therapy in the treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ursolic acid, a potential anticancer compound for breast cancer therapy by Yin R1, Li T1, Tian JX1, Xi P1, Liu RH. (PubMed)
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