Honey Exerts a Protective Effect Against Toxic Materials in Vivo, According to Scientists

Kyle J. Norton

The liver is a large organ in the human body that processes a number of functions, including producing bile to aid digestion, detoxifying metabolites, synthesizing proteins, and filtering blood from the digestive tract before passing them to other parts of the body.

Symptoms of liver toxicity include gastrointestinal discomforts such as nausea, vomiting, and jaundice. Some patients with liver toxicity also experience the symptom of right upper quadrant abdominal pain.

If you have some of the aforementioned symptoms, please check with your doctor immediately. Acute liver toxicity may be life-threatening.

The most common causes of liver toxicity in the Western world are excessive alcohol drinking and long-term use of certain medications and overdoses of herbal supplements.


Dr. Victor Navarro, M.D. in the examination of the herbal and dietary supplements in risk liver toxicity wrote, "Herbal and dietary supplements (HDS) -induced liver injury now accounts for 20% of cases of hepatotoxicity in the United States based on research data".

And, "The major implicated agents include anabolic steroids, green tea extract, and multi-ingredient nutritional supplements (MINS)".

The results strongly suggested if you are currently using some of the herbal and dietary supplements, please make sure that you follow the direction and guidelines set out in the products to prevent unnecessary live toxicity.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener.

On finding the natural and potential ingredient for the prevention of liver toxicity, researchers investigated honey's protective effect against toxic materials.


The study included 24 male rabbits allocated into four groups six rabbits each given daily during 24 days of experimentation; group 1: the control group, received distilled water (0.1 ml/kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily).

Injection of the lead group induced hepatic injury and caused anemia during three weeks of exposure.

Treatment with honey in the lead group not only prevented liver lead toxicity but also ameliorated lead-induced anemia.

The results clearly suggested that honey has a protective effect against lead-induced blood, hepatic, and toxic effects.

Furthermore, in order to reveal more information about honey liver protective activity, researchers examined the Manuka and Talh honey against cisplatin (CISP)-induced hepatotoxicity in a rat model.

Before the injection of Manuka and Talh honey, rats treated with CISP-induced liver dysfunction were observed with liver toxicity.

Administration of Manuka honey prevented CISP-induced histopathological changes observed in the rat liver but not in the kidney.

Manuka and Talh honey also reduced oxidative stress in the liver by stimulating the production of antioxidant enzymes from the treated rats.

In other words, both jars of honey inhibited the expression of proinflammatory cytokines including COX-2 and NF-κB by the cisplatin (CISP)-induced hepatotoxicity.

Taken altogether, honey, particularly Manuka and Talh honey may be considered function remedies for the prevention and treatment of liver toxicity, pending to the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress-dependent BAX/Bcl-2/caspase-3 apoptotic pathway by Neamatallah T 1, El-Shitany NA, Abbas AT, Ali SS, Eid BG. (PubMed)
(2) Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity by Fihri AF1, Al-Waili NS, El-Haskoury R, Bakour M, Amarti A, Ansari MJ, Lyoussi B. (PubMed)
(3) Liver Injury from Herbal and Dietary Supplements by Victor Navarro, M.D.,1 Ikhlas Khan, Ph.D.,2 Einar Björnsson, M.D., Ph.D.,3 Leonard B. Seeff, M.D.,1 Jose Serrano, M.D., Ph.D.,4 and Jay H. Hoofnagle, M.D.(PMC)

Canned Beverages Containing Mixed Green #Vegetables and #Fruits With #Broccoli and #Cabbage Process Anti-Hyperlipidemic Activity, According to Studies

Kyle J. Norton

High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million American and the condition is increasing at an alarming rate due to overweight and obesity.

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

The condition is normally known as high blood cholesterol in the general population.

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, and produces vitamin D and steroid hormones.

Cholesterol can either be produced by the liver or consumed from food sources. There are 2 types of cholesterol
*The high-density lipoprotein also known as "good" cholesterol processes a function to return cholesterol to the liver.

* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in a moderate amount.

In a healthy individual, the bad cholesterol is returned to the liver.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances forms plaque, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

In finding a potential plant that processes anti-anti-hyperlipidemia, researchers examined the serum LDL-cholesterol (LDL-C)-lowering effects of two types of canned beverages containing mixed green vegetables and fruits, with or without broccoli and cabbage (B&C).

The randomized double-blind study design included 77 adult subjects with mild to moderate hypercholesterolemia (Forty-nine out of 77 subjects, whose LDL-C levels were greater than or equal to 140 mg/dl and less than 180 mg/dl) were randomly divided into groups either by a placebo sample made from the same materials but without B&C. The subjects were administered 2 cans of 160 g contents/can) per day for 12 weeks.


According to the results of the experiment,

* Serum LDL-C levels in the test group were significantly reduced at 3, 6, and 9 weeks after administration in comparison to the baseline levels (155.7 mg/dl on average).

* The average LDL-C value at 9 weeks was 142.5 mg/dl and the reduction rate was 8.5% compared to serum LDL-C levels in the control group that were not significantly reduced.

* Significant differences(p < 0.05) between the groups were observed in the LDL-C levels at 6 and 9 weeks and also in the total cholesterol levels at 9 weeks.

Collectively, researchers said, "Intake of the beverage tested containing B&C is useful for lowering serum LDL-C levels in hypercholesterolemic subjects".

Taken altogether, broccoli used in combination with cabbage may be considered a functional food for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [LDL-cholesterol-lowering effect of a mixed green vegetable and fruit beverage containing broccoli and cabbage in hypercholesterolemic subjects].[Article in Japanese] by Takai M1, Suido H, Tanaka T, Kotani M, Fujita A, Takeuchi A, Makino T, Sumikawa K, Origasa H, Tsuji K, Nakashima M. (PubMed)

#Herbqal #Eyebright Extract Exerts a Significant Activity Against #Hypoglycemia in Vivo, Researchers Suggest

Kyle J. Norton

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.
Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

In other words, hyperglycemia is a hallmark in patients with diabetes, the condition can also occur to people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms of shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Over the long term, persistently mild hyperglycemia can lead to complications in the eyes, kidneys, nerve damage and heart disease, and stroke.

Most cases of hyperglycemia can be controlled by following diabetes guidance.

By eating a healthy diet high in fiber, such as vegetables, fruits, nuts, legumes (beans, peas, and lentils), whole-wheat flour, and wheat bran, accompanied by healthy fish, patients with type 1 and 2 diabetes can control their blood glucose without worrying the onset of hyperglycemia.


The most common causes of hyperglycemia are associated with an uncontrolled diet, improper use of insulin, and skipping diabetic medication.

The most common symptoms of hyperglycemia are increased thirst frequent urination, fatigue (weak, and unintended weight loss. In severe cases, some patients may also experience symptoms of headaches, trouble concentrating, and blurred vision.

In finding a natural ingredient for the prevention and treatment of high blood glucose, scientists examined the effects of the aqueous extract of the leaf of Euphrasia officinale.

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe.


The plant has been used in traditional and herbal medicine to treat eye infections and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

The study included selected rats that were assigned to healthy normal or alloxan-induced diabetic rats

According to tested analysis and compared to the levels of blood glucose levels in normal and alloxan-diabetic rats

* Treatment of alloxan-induced diabetic rats showed a strong effect by bringing down the raised glucose levels,

* The extract administration exerted a significant activity against hypoglycemia in normal and diabetic-induced rats.

In other words, the aqueous extract of the leaf of Euphrasia officinale. not only has a strong activity against levels of blood glucose but also ameliorated hyperglycemia in diabetic experimental rats.


Taken together, Eyebright (Euphrasia)may be considered a remedy for the treatment of hyperglycemia, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihyperglycemic activity of Euphrasia officinale leaves by Porchezhian E1, Ansari SH, Shreedharan NK. (PubMed)

#DevilsClub Ethanol #Extract Used Alone or Combined with #Paclitaxel Show a Strong Inhibition of Human #PancreaticCancer, According to Studies

Kyle J. Norton

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.

At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue, and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.


The pancreas cancer was found to be the site of metastasis from renal cell cancer, lung, colon and breast cancers.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer.

The 5-year survival rate including all stages of people with pancreatic cancer is 8%, compared to 32% of cancer detected at an early stage.

Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).

Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age, and ethnicity are associated with the early onset of pancreatic cancer.

Devil's Club (DC) is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America.

The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, and Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.

In finding a potential compound for the treatment of cancer, researchers examined the effects of DC 70% ethanol extract alone, or in combination with cisplatin, gemcitabine, and paclitaxel on pancreatic endocrine HP62 and pancreatic ductal carcinoma PANC-1 and BxPC-3 cells.

According to the tested differentiation,* DC extract inhibited proliferation of HP62 with IC50 (50% inhibition concentration) at 0.037±0.002% (v/v), PANC-1 at 0.0058 ± 0.0004% and BxPC-3 at 0.021 ± 0.003%.

* DC at 0.0033% combined with 1 nM of paclitaxel showed inhibition synergy on PANC-1 cells with a combination index of 0.44.

* Increased cytochrome C, claspin, cIAP-2, and HTRA2/Omi apoptosis-related markers were upregulated in DC-treated HP62 and PANC-1.

Collectively, researchers suggested, "DC acts through targeting the intrinsic mitochondrial apoptosis pathway in the pancreatic cancer cells.

And, "The high antiproliferation potency of DC on PANC-1 is potentially useful as an adjunct therapy for treating pancreatic cancer, which is known for developing resistance to conventional chemotherapeutics".

Taken together, Devil's Club may be considered a remedy for the treatment of pancreatic cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound by Cheung SS1, Tai J, Hasman D, Ou D, Warnock GL. (PubMed)

Low Levels of Serum of #Tocopherols in the Body Are Associated with An Increased Risk of #AgeRelatedMacularDegeneration #AMD

Kyle J. Norton

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, and medical conditions, such as alcoholism, brain cancer, or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.

Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.

The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increase in size.

Advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to epidemiological studies.

According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.


Age-related macular degeneration can be classified into 2 types
* The common AMD is the dry form caused by the gradual degeneration of the central retinal tissues, affecting 90% of patients with AMD. Some patients with the dry form of AMD have been found to develop into the wet form over time.

* The wet form of AMD is caused by the breaking of the capillary under the macula, accounting for only 10% of AMD.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

In finding a potential phytochemical for the treatment of degenerative diseases, researchers compared the effects of dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene on age-related macular degeneration.

According to the results of a brief-type self-administered questionnaire of the case-control study that reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) from 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects in Japan,
* Low intakes of n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene were associated with neovascular AMD.

In other words, low levels of serum of tocopherols were associated with an increased risk of AMD.

* There was no association between retinol or cryptoxanthin intake and neovascular AMD.

These results were adjusted based on smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption


Taken together, tocopherols may be considered an adjunct therapy in the treatment of AMD, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan by Aoki A1,2, Inoue M3, Nguyen E4, Obata R1, Kadonosono K3, Shinkai S2, Hashimoto H5, Sasaki S4, Yanagi Y. (PubMed)

#Herbal #CrampBark Leaf Methanol #Extract Inhibits the Acetylcholinesterase Effects on #NeurodegenerativeDiseases, According to Studies

Kyle J. Norton

The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).

Acetylcholinesterase (AChE) is the primary enzyme that hydrolyzes the neurotransmitter acetylcholine to choline and acetate.

Altered levels of ACh in the nervous system have been found to induce several neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington, depending on the affected areas.

Butyrylcholinesterase (BuChE) enzyme plays a minor role in regulating brain acetylcholine (ACh) levels.

A cholinergic neuron is a nerve cell that mainly is used by the neurotransmitter acetylcholine (ACh) to send its messages

Impairment of the cholinergic neuronal system in the brain was involved in the underlying event of cognitive impairment.
Cholinesterase inhibitors (ChEI) have been used for the treatment of Alzheimer's disease (AD).

Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as an anti-spasmodic, anti-inflammatory, and nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with menopause, etc.


In finding a potential herbal medicine for the prevention and treatment of neurodegenerative diseases, researchers examined ethyl acetate, methanol, and water extracts prepared from the branches, leaves, and fruits of Viburnum opulus and Viburnum lantana along with salicin on acetylcholinesterase (AChE) inhibitory and antioxidant activities.

In vitro, according to the results from an enzyme-linked immunosorbent assay, the leaf methanol extract of V. opulus displayed a significantly high inhibitory effect against AChE at 50, 100, and 200 μL/mL concentrations of 57.63%, 87%, and 93%, respectively compared to other extracts.

In other words, the leaf methanol extract of V. opulus showed the highest protective activity against the disruption of neurons in the induction of neurodegenerative diseases linearly in a doses dependent-manner.

Compared to Viburnum opulus, the extracts of V. lantana exerted higher antioxidant activity.

Taken together, cramp bark(Viburnum opulus) leaves may be considered a functional acetylcholinesterase inhibitor herb medicine for the prevention and treatment of neurodegenerative diseases, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents by Erdogan-Orhan I1, Altun ML, Sever-Yilmaz B, Saltan G. (PubMed)

#Bromelain Combined #Peroxidase (BM-PR) Inhibit Acute #Leukemia Cancer Cell Proliferation and Altered the Morphological Features, According to Studies

Kyle J. Norton

Leukemia is a medical and chronic condition that affects the blood and bone marrow associated with the production of immature white blood cells that can not function properly.
Leukemia can be classified into 2 types
A. Acute leukemia
Acute leukemia is a condition of the rapid increase in the number of extremely immature white blood cells which appear in the bloodstream and other parts of the body, including tissue and organs.

* Acute lymphocytic leukemia (ALL) is a type of cancer caused by the abnormal growth of extremely immature lymphocytes by the bone marrow and/or lymphatic system. Acute lymphoblastic leukemia (ALL) is the most common child form of leukemia, accounting for 80% of all cases.

* Acute myelogenous leukemia (AML) is a cancer of the myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells.

B. Chronic leukemia
Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells.

* Chronic lymphocytic leukemia (CLL) is a condition caused by the slow growth and spreading of a group of abnormal white blood cells called B-cell lymphocytes, which fight against infection in our body by producing antibodies.

* Chronic myelogenous leukemia (CML) is a condition caused by the slow growth and spreading of abnormal granulocytes.

The exact causes of leukemia are unidentified. Researchers do not know the exact factors that cause the alteration of cell DNA that promotes the abnormal growth of white blood cells.

However, they do know aging, family factors, male, smoking, long-term exposure to certain chemicals, chemo, and radiation therapies, genetic proposition, and certain types of blood disorders are associated with the increased risk of the disease.


Leukemia shared all general symptoms with other types of cancer such as unintended weight loss, loss of appetite, gastrointestinal discomforts, and persistent fatigue accompanied by specific symptoms of bleeding or bruising, recurrent nosebleeds, tiny red spots in your skin, excessive sweating, and hight time bone pain or tenderness.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to discover a potential compound or whole food for the treatment of leukemia, researchers investigated a panel of cancer cell lines with bromelain in the presence or absence of peroxidase.

Bromelain combined with peroxidase (BM-PR) showed significant inhibition of acute myeloid (K562) cell proliferation and altered the morphological features.


The combination not only exhibited pro-apoptosis against the cancer cell line but also interfered with the cell cycle division through cell cycle arrest.
BM-PR also increased the expression of intracellular ROS levels in the induction of cytotoxicity and altered the mitochondrial membrane potential, against the tested cancer cells.

According to the Western blot analysis, BM-PR increased the levels of proteins associated with the activity of proapoptosis and tumor suppression.

Compared to the treatment of bromelain, researchers said, "These results suggest that BM-PR from pineapple induces apoptosis better than the only bromelain in acute myeloid leukemia cells possibly via mitochondria-dependent pathway".

In CD44 cell surface proteins involved in leukocyte binding to endothelium and the metastatic spread of tumor cells, injection of bromelain inhibited the human leukemia Molt 4/8 cells growth by reducing CD44 receptor density.

The most active in reducing CD44 receptor density of bromelain was a half-maximal value of 1.9 mu g/ml and 2.3 mu g/ml.

Based on the findings, bromelain inhibited the progression of leukemia via the reduced CD44 receptor density.

Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of leukemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain with peroxidase from pineapple is more potent to target leukemia growth inhibition - A comparison with only bromelain by Debnath R1, Chatterjee N2, Das S3, Mishra S4, Bose D4, Banerjee S4, Das S4, Saha KD5, Ghosh D6, Maiti D. (PubMed)
(2) Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemia and sk-mel-28 melanoma-cells in-vitro by Harrach T1, Gebauer F, Eckert K, Kunze R, Maurer H. (PubMed)