#Aqueousextract of #BearberryLeaves Exert Hypotensive Acitivity without Changing the Heart Rate in Vivo, Scientists Find

Kyle J. Norton

Herbal Barberry may be considered a functional food and natural alternative in the prevention and treatment of high blood pressure quickly with no adverse effects, some scientists suggested. High blood pressure or hypertension is a medical condition characterized by abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

The normal range of blood pressure is 120 over 80. The number at the top is systolic blood pressure, and the bottom is called diastolic blood pressure.

Researchers do not know the exact causes of hypertension. However, researchers do know that certain preventable risk factors such as smoking, being overweight or obese, physical inactivity,.... and excessive alcohol drinking are associated to increase risk of hypertension.

Prolonged periods of raising the pressure of the heart can lead to damage to the body in many ways.

Uncontrolled high blood pressure can lead to stroke and heart disease by damaging and weakening your brain's blood vessels, a blood clots in the arteries.

An unhealthy diet high in salt, sugar, process products, genetic mutation, aging, family history,... and long-term stress also has a substantial impact on the onset of hypertension.

Dr. Kim EJ, the lead author in the study of the dietary effect in patients with borderline hypertension, suggested, " a short-term (12 weeks) lifestyle intervention had positive effects on blood pressure control and weight reduction in the subjects, but not on their blood levels of adipokines. It is interesting that the blood level of baseline leptin was negatively associated with the changes in blood pressure after this short-term intervention"(3).

The results showed that long-term dietary intervention should have a strong impact on keeping blood pressure in check.

Adipocytes found in the obese population may contribute to the high prevalence of hypertension.

Leptin, a chemical compound in the blood plays a critical role in the regulation and arterial hypertension
Conventional blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they can induce serious side effects, including common gastrointestinal discomfort and psychological symptoms,

Lifelong intake of hypertension medicine can cause erectile dysfunction.

If you take the medicine in the long term, please make sure you discuss the side effects with your doctor.

Bearberries are 3 species in the genus Arctostaphylos, belongings to the family Ericaceae, native to northern North America, Asia, and Europe.

The herbs have been used in traditional medicine as diuretic agents and to treat urinary problems, including bladder infections, kidney infections, kidney stones,.... and pelvic pain.


The Chemicals Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides,..... and flavonoids.

With the aim to find the possible hypotensive activity of the aqueous extract of Vaccinium Arctostaphylos leaves, the Shiraz University of Medical Sciences conducted an experiment of rats with two-kidney, one-clip hypertension.

All rats were subjected to a sham operation of the placement of a Plexiglass clip on left renal arteries.

After four weeks of surgery, renal artery-clipped rats were either injected intravenously with different doses of the extract at 10, 25, or 75 mg/kg or normal saline.

The mean blood pressure and heart rate were measured before and 20, 40, and 60 minutes after vehicle or drug administration, researchers found that

* Group given normal saline has a significantly higher mean blood pressure, heart, and right kidney weights, lower left kidney weight, and significantly indifferent heart rate.

* Treatment group with the injection of the extract at 75 mg/kg exerts a reduction of the mean blood pressure at 20, 40, and 60 minutes after administration without changing the heart rate.

* However, groups treated with doses of but 10 or 25 mg/kg show an insignificant change of mean blood pressure compared to groups administrated with the extract at 75 mg/kg.

These results suggested that bearberry leaf extract has the potential in reduced blood pressure in a dose-depended manner.

Dr. Khalili A, the lead author of the final report, wrote, "... at a higher dose the extract did have hypotensive activity without changing the heart rate".

Taking all together, herbal bearberry and its extract may be considered a functional food for the treatment of high blood pressure.


However, further data collection on large example size and multi-center studies performed with human consumption of the herbal leaf extract during the course of the disease will be necessary to complete the picture of bearberry hypotensive possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
1. The effects of aqueous extract of vaccinium arctostaphylos leaves on blood pressure in renal hypertensive rats. by Khalili A, Khosravi MB, Nekooeian AA. (PubMed)
2. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats by Beaux D, Fleurentin J, Mortier F.(PubMed)
(3) Effects of a 12-week lifestyle intervention on health outcome and serum adipokines in middle-aged Korean men with borderline high blood pressure by Kim EJ1, Cho SW, Kang JY, Choi TI, Park YK(PubMed)

The #Coffee and #CoffeeCaffeine Effects Against the Risk of #UlcerativeColitis, Researchers Reveal

Kyle J. Norton

Epidemiological studies do not agree that intake of coffee and coffee caffeine regularly may have a profound effect in attenuating the risk of ulcerative colitis.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

Ulcerative colitis is an inflammatory bowel disease characterized by long-lasting inflammation and ulcers (sores) in the digestive tract.


In the reviewed study of a total of 442 patients, 73% regularly consume coffee. 96% of patients attributing a positive and 91% of patients attributing no impact of coffee intake on IBD regularly drink coffee and surprisingly even 49% of those patients assign a negative impact on disease symptoms, researchers at the University Hospital Zurich found that most patients with IBD showed a coffee drinking habit and addressed that coffee has helped to modify symptoms of the disease.

Other in the total of 81 UC patients recruited at all stages of the disease process, after completion of a 7 d diet diary, Caffeine, and decaffeinated coffee showed a clinical significance in reduced risk of UC and may be considered a functional food included in the potential therapeutic diet.

Dr. Magee EA, the lead author said, " ......decaffeinated coffee was associated with a better clinical state than the caffeine-containing version".

Contrastively, in the investigation of a population-based, case-control study of the risk of ulcerative colitis associated with coffee and alcohol use among the 304,000 members of a prepaid health plan, coffee expressed no association with either amount of coffee consumed daily, or cumulative coffee consumption before disease onset and altered the risk of developing ulcerative colitis.

Taken together, the findings showed an inconclusive result of the efficacy of coffee and coffee caffeine consumption in reducing the risk of ulcerative colitis. Therefore more cohost with large sample size studies is necessary before coffee can be confirmed as a functional food for use in reduced onset and treatment of ulcerative colitis.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Patients' perceptions on the impact of coffee consumption in inflammatory bowel disease: friend or foe?--a patient survey by Barthel C1,2, Wiegand S3,4, Scharl S5, Scharl M6,7, Frei P8, Vavricka SR9, Fried M10, Sulz MC11,12, Wiegand N13,14, Rogler G15,16, Biedermann L17.(PubMed)
(2) Associations between diet and disease activity in ulcerative colitis patients using a novel method of data analysis by Magee EA1, Edmond LM, Tasker SM, Kong SC, Curno R, Cummings JH.(PubMed)
(3) Coffee and alcohol use and the risk of ulcerative colitis by Boyko EJ1, Perera DR, Koepsell TD, Keane EM, Inui TS.(PubMed)

#Anthocyanins in #Bilberry Exert Protective Effects Against NeuroToxicityAgainst the Onset of#Parkinson's disease (PD), Researchers Say

Kyle J. Norton

Parkinson's disease (PD) is a chronic medical condition that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.
In other words, Parkinson's disease is a progressive central nervous system disorder that affects neurons in transmitting messages in controlling movement.

Some patients in the very early stage of PD may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.
Researchers do not know why the neurons in the brain in some people are susceptible to gradually breaking down or dying while others do not even though they have similar health conditions and are from the same family.

However, they do know, according to the epidemiological study, aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the risk factors found in patients with PD.


Please note that most people process some of the conditions that have never developed Parkinson's disease.

Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink caffeine found in coffee, tea, and cola are less likely to get Parkinson's disease compared to those who don't.

Dr. Prediger RD at the Universidade Federal de Santa Catarina wrote, "Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population older than 60 years".

And, "The available data also suggest that caffeine can improve the motor deficits of PD and that adenosine A2A receptor antagonists such as istradefylline reduces OFF time and dyskinesia associated with standard 'dopamine replacement' treatments".

The results strongly suggested if you drink caffeinated beverages, your risk of PD is decreased substantially.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

With an aim to find a natural ingredient that processes neuroprotective effects against Parkinson's disease, researchers examined the Anthocyanin-rich preparations of Vaccinium species, including bilberry against the oxidative damage in dopaminergic neurons.

V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins showed a significant neuron protection activity by inhibiting oxidation caused by the chain reaction of reactive oxygen species (ROS).

The application was found to be 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.

According to the analysis of the chemical constituents, the neuroprotective effects were attributed to the presence of bioactive compounds anthocyanins and total cyanidins found abundantly in bilberry, but not quercetin or myricetin.

The results suggested that the high potency of anthocyanins processes a potentially neurotoxic reaction against the onset of Parkinson's disease.

Dr. Yao Y, the lead scientist wrote, "(the findings) provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".

Taken altogether, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of Parkinson's disease, pending the validation of a larger sample size and multicenter human study.


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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease--phagocyte influx to the brain is promoted by bilberry-enriched diet by Virel A1, Rehnmark A1, Orädd G2, Olmedo-Díaz S1, Faergemann E1, Strömberg I. (PubMed)
(2) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(3) Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms by Prediger RD. (PubMed)

#Ashwagandha Inhibits #Oxidativestress in Post Stroke Management Against the Onset of #MitochondrialDysfunctions and Cognitive Impairments

Kyle J. Norton

Stroke is a condition in which the brain function is interrupted rapidly due to the loss of blood supply as a result of the blockage of blood such as thrombosis and arterial embolism, or leakage of blood causes the death of brain cells, according to the article of Mitochondria, oxidative metabolism, and cell death in stroke by Sims NR, Muyderman H (September 2009).

In other words, stroke can be caused by either ischemia, due to lack of blood flow, or hemorrhagic, due to bleeding.

A stroke is a medical emergency. Early intervention in most cases can minimize brain damage and potential complications.

There is a general belief that stroke is an accumulation over a long period of an unhealthy diet with red meat and processed meats in the induction of artery-clogging.

Some researchers suggested that increased intake of fruits and vegetables such as carrots accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow, and decreased the chance of blood clots.

Sadly, stroke is one of the most common causes of death worldwide.

In the US, according to statistics, approximately 800,000 people suffer a stroke of which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

Stroke is also the third leading cause of death. Approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention of disease associated with plaque accumulated on the arterial wall, researchers examined the effects of Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in an experimental model of ischemic stroke.

According to the tested analysis, before treatment with WS, tested mice showed an ischemia-reperfusion injury, leading to the increase of the oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels and low levels of antioxidant enzymes.

The untreated mice also exerted decreased antioxidant enzymes superoxide dismutase and catalase activity, along with a reduction in GSH levels and the redox ratio, impaired mitochondrial functions, and enhanced expression of apoptosis markers.

Ischemia-reperfusion injury in the tested mice also induced mitochondrial dysfunctions.


Moreover, the levels of pro-inflammatory and apoptotic proteins were also increased in the untreated mice. The Y maze test also indicated a significant impairment in cognitive functions in the tested animal.


However, WS pre-supplementation ameliorated all parameters associated with the induction of MCAO such as oxidative stress, mitochondrial dysfunctions, apoptosis, and cognitive impairments.

Based on the evidence, researchers said, "WS pre-supplementation in ischemic stroke and are suggestive of its potential application in stroke management".

Taken altogether, Ashwagandha may be considered a supplement for stroke management, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indian Ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in an experimental model of stroke by Sood A1, Mehrotra A1,2, Dhawan DK3, Sandhir R. (PubMed)

#Diterpenoid C Extract in Herbal #Turmeric Inhibits Bacteria Associated with the Risk of #Gastritis, Scientists Find

Kyle J. Norton

Gastritis is a group of conditions associated with the inflammation of the lining of the stomach caused by infection of the bacterium, leading to stomach ulcers developing.
A stomach ulcer is an open sore in the lining of the stomach. In most cases, it is a result of bacterial infection that leads to the erosion of the gastric lining by stomach acid.

Other causes of gastritis are long-term excessive alcohol consumption and the use of certain medications such as aspirin.

There are 2 types of gastritis
* Acute gastritis occurs suddenly as a result of inflammation or swelling in the lining of the stomach. and only affects the stomach and induces nausea or vomiting,

* Chronic gastritis is a condition that develops slowly due to chronic inflammation or damage of the stomach lining that has not healed.

Patients with chronic gastritis if untreated were found to have a substantial risk of stomach cancer.
The most common symptoms of gastritis are a burning sensation or pain in the upper abdomen, nausea, vomiting, and abnormal feeling of fullness in the upper abdomen after eating.


Out of many risk factors involved in the onset of the condition, some researchers in the observation of the correlation of high-fat diet-induced obesity over the past few decades, in the risk of gastritis wrote, "Obesity has become a major concern among gastroenterologists due to its large influence on gastrointestinal and hepatic diseases: reflux esophagitis, pancreatitis, gallstone disease, liver fibrosis, and neoplastic tumors of the esophagus, pancreas, and colon".

And, "the effects of obesity on endoscopic gastritis in subjects undergoing health check-up examination, and demonstrated that adiponectin, a bioactive molecule released from visceral fat, could be a protective factor of endoscopic gastritis".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of gastric inflammation, researchers examined the effect of diterpenoid C extracted from radix curcumin on Helicobacter pylori (H. pylori)-infected inflammation, and intestinal metaplasia.

The study included human gastric epithelial gastric epithelium cell line (GES-1) infected by I-type H. pylori treated with radix curcumae (RC)-derived diterpenoid C of different concentrations (5, 10, 20 μg/mL) and amoxicillin.

According to the MTT assay, IC5 of RC-derived diterpenoid C and amoxicillin of 5 μg/mL inhibited the progression rate of GES-1.

The combination also inhibited the production of pro-inflammatory cytokines and exhibited the production of anti-inflammatory cytokines associated with the injection of I-type H. pylori in the GES-1,
particularly, at 12, 24, 48, and 72 h points.

In other words, the combination protects the stomach against gastric inflammation by blocking the activation of a protein involved in the stimulation of pro-inflammatory cytokines.

Based on the findings, researchers wrote, "RC-derived diterpenoid C can block NF-κB signal pathway, effectively reducing the secretion of H. pylori-induced proinflammatory cytokine and increasing the secretion of anti-inflammatory cytokine".

In Helicobacter pylori infection of the lining of the stomach induces an array of inflammatory cytokine production that leads to gastritis and peptic ulcer disease, researchers at the Uttaradit Hospital conducted an experiment to investigate the effect of curcumin on the production of interleukin (IL)-8, IL-1beta, tumor necrosis factor (TNF)-alpha and cyclooxygenase (COX)-2 in gastric mucosa from H. pylori-infected gastritis patients.

Selected patients were randomly assigned to receive either OAM (Omeprazole, Amoxicillin, and Metronidazole) treatment and/or a course of curcumin.

According to the tested assays, curcumin alone may have a limited anti-bactericidal effect on H. pylori, and on the production of inflammatory cytokines compared to those of the OAM group.


However, the curcumin group showed significant relieving symptoms with a lower rate in the eradication rate of H. pylori and no decreased cytokine production.

Precisely, curcumin used alone has limited efficacy compared to that of the combination in reducing gastric inflammation.

Taken altogether, turmeric processed abundant bioactive ingredient curcumin may be combined with other conventional medicines for the prevention and treatment of gastric inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways by Huang X1, Lv B, Zhang S, Dai Q, Chen BB, Meng LN. (PubMed)
(2) Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients by Koosirirat C1, Linpisarn S, Changsom D, Chawansuntati K, Wipasa J. (PubMed)
(3) Is obesity a new risk factor for gastritis? by Yamamoto S1, Watabe K, Takehara T. (PubMed)

#Broccoli's Extracts BCE Enhance the Antioxidant Enzymes Against the Onset of Diabetic Cardiomyopathy, Researchers Say

Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell
Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased the accumulation of fluid in the lungs.

Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.

* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of heart diseases, researchers examined the effect of sulforaphane, an active compound and an Nrf2 activator found in broccoli on diabetic cardiomyopathy (DCM), male db/db and age-matched wild-type (WT) mice.

According to the experimental results from the analysis of broccoli sprout extract (BSE) by gavage every other day for 3 months, with four groups: vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high dose (estimated SFN availability at 1.0 mg/kg), and SFN (0.5 mg/kg),

* BSE, like SFN, showed a significant up-regulation of the Nrf2 transcriptional activity involved in the enhancing antioxidant enzymes observed by the increased Nrf2 nuclear accumulation and gene expression.

* The increased levels of antioxidant enzymes exerted a strong effect on the prevention of cardiac oxidative damage and inflammation.

* Additionally, the BSE at high dose provided a similar effect as did SFN.

Based on the results, researchers wrote, " BSE at high dose prevents DCM in a manner congruent with SFN treatment. Therefore, it suggests that BSE could potentially be used as a natural and safe treatment against DCM via Nrf2 activation".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice by Xu Z1,2, Wang S1,2, Ji H1, Zhang Z1, Chen J2, Tan Y2,3, Wintergerst K3,4, Zheng Y1, Sun J1, Cai L. (PubMed)

#Polysaccharides in Broccoli Exerts Anti-Metastatic Activities Via Natural Killer (NK) Function in GM1 Activity, According to Studies

Kyle J. Norton

Cancer is a class of diseases associated with irregular cell growth in the tissue of a specific organ.
Most cases of invasive cancer can spread to other organs in the body via lymph or blood.

According to the statistics provided by the Cancer Institute, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).

The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.

In cancer cells, due to the alternation of DNA, can grow indefinitely.

Cancer cell metastasis is the process in which cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

Through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interactions.

In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines at the site of the damage. The inflammatory cytokines not only play a critical role in stopping the stimuli from entering the body but also speeds up wound healing through growth factors.

The innate immune system also can destroy damaged cells such as cancer cells through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53.

Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

In finding natural food for the prevention and treatment of cancer proliferation, researchers examined the anti-metastatic activities of polysaccharides in broccoli, including BCE-I mainly consisted of galactose and arabinose, whereas BCE-II mainly consisted of galacturonic acid and rhamnose, and BCE-III mainly consisted of rhamnose and galactose.

According to the results of the analysis,
* BCE-I showed the greatest enhancement of the pro-inflammatory proteins such as tumor necrosis factor-α, interleukin (IL)-12, and IL-6 secretion by stimulating murine peritoneal macrophages in the immune response.

* Furthermore, intravenous (i.v.) administration of BCE-I enhanced the lethal activity on YAC-1 tumor cells significantly and dose-dependently in an ex vivo by exhibiting the natural killer (NK) cells.

* In lung metastasis of Colon26-M3.1 carcinoma cells, prophylactic i.v. and oral administration of BCE-I significantly and dose-dependently inhibited lung metastatic activity.

In other words, the inhibitory activity of BCE-1 on lung metastasis are depending on the NK cell function in GM1 activity.

Based on the results, researchers wrote, " BCE-I has potent antitumor metastatic activity, and that its anti-metastatic activity has relevance to the stimulation of NK and other immune cells".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for inhibiting cancer cell metastasis, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Rhamnogalacturonan-I-Type Polysaccharide Purified from Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation by Kwak BS1, Hwang D2,3, Lee SJ1, Choi HJ4, Park HY5, Shin KS. (PubMed)