#ManukaHoney Inhibits the Proinflammatory Cytokines and Mast Cell Degranulation Associated with #AtopicDermatitis, Researchers Reveal

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have found a herbal remedy for the prevention and treatment of atopic dermatitis, according to studies.

Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.

Most cases of atopic dermatitis are found in children. However, adults may also get it too. Skin irritation is found more often in children compared to adults.


The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environmental conditions may be involved in the development of the disease.


Epidemiological studies suggested that most patients with chronic atopic dermatitis also have asthma and hay fever, particularly in allergies.

Some researchers suggested that atopic dermatitis is more common in people who live in the air pollution city.

Dr. Ahn K in the study of the role of air pollutants in atopic dermatitis, wrote, " Both indoor and outdoor air pollution, which are of increasing concern with urbanization, are well-known environmental risk factors for asthma, whereas there is relatively little evidence in AD".


And, " epidemiologic and experimental data on the role of air pollution in patients with AD. Recent evidence suggests that a variety of air pollutants, such as environmental tobacco smoke, volatile organic compounds, formaldehyde, toluene, nitrogen dioxide, and particulate matter, act as risk factors for the development or aggravation of AD. These air pollutants probably induce oxidative stress in the skin, leading to skin barrier dysfunction or immune dysregulation".

The results clearly suggested the risk of atopic dermatitis increases with air pollutants.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers in the course to find a natural ingredient for the treatment of dermatitis examined the Manuka honey anti-skin conditions and dermal injuries.
Injection of Manuka honey showed a significant potency in the treatment of a severe atopic contact dermatitis eczematous reaction with no side effects.

Furthermore, adult volunteers with bilateral atopic dermatitis (AD) were asked to apply MH on one site overnight for seven consecutive days and leave the contralateral site untreated as possible.

There are no significant changes in the skin staphylococci observed after day 7, irrespective of honey treatment.

However, MH treatment showed significant inhibition of proinflammatory cytokines in a dose-dependent manner.

The application of MK also inhibited mast cell degranulation against the onset of atopic dermatitis (AD).

Dr. Alangari AA, the lead scientist said in the final report, "MH is potentially effective in the treatment of AD lesions based on both clinical and cellular studies through different mechanisms".

Taken altogether, Manuka honey may be considered a functional remedy for the prevention and treatment of atopic dermatitis (AD) with no side effects, pending the confirmation of a larger sample size and multicenter human study.


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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Manuka Honey: A Case Study of Severe Atopic Eczematous Dermatitis Reaction to Henna Tattoo by Harrison J. (PubMed)
(2) Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies by Alangari AA1, Morris K2, Lwaleed BA3, Lau L4, Jones K2, Cooper R2, Jenkins R. (PubMed)
(3) The role of air pollutants in atopic dermatitis by Ahn K. (PubMed)

Herbal #Angelica Suppresses the Anti Apoptotic and Proliferrative Pathways Associated with the Onset of #Glioblastoma Multiforme (GBM)

Kyle J. Norton

Cancers are the class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.

Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.

According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.

If you are male you are at 1.5 higher risks of glioblastoma, compared to your female counterpart.

The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, and a weakened immune system may be some risk factors associated with the onset of the disease.

However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.

Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.

Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.

Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.

In finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).

Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptotic pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.

* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.

* Lack of growth factors involved in cell proliferative and differentiation.

Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effects".

Taken together, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)

#Lycopene Processess Anti #AcutePancreatitis Property by Inhibiting the Expression of ROS, According to Studies

Kyle J. Norton

Pancreatitis is a condition associated with the inflammation of the pancreas.
Most cases of pancreatitis are involved in the abnormal activation of digestive enzymes in the small intestine that attacks the pancreas.

According to the statistics, in the Western world, the incidence of chronic pancreatitis rate is 5-12/100,000.

Epidemiologically, the chronic condition is found mostly in patients between the ages of 30 and 40 and more common in men than women.

Acute pancreatitis is an inflammation that starts rapidly and lasts for a short time. The condition can be mild or severe. In mild cases, most patients are recovered quickly if the cause is found.


In severe cases, acute pancreatitis can be life-threatening. The condition has been found to induce bleeding into the gland, serious tissue damage, infection, and cyst formation.


In some patients, the condition also can cause damage to vital organs such as the heart, lungs, and kidney

The most common symptoms of acute pancreatitis are upper abdominal pain, swollen and tender abdomen, nausea and vomiting, fever, and increased heart rate.

If you have some of the aforementioned symptoms that persistently with no signs of healing. Please check with your doctor to rule out the possibility of acute pancreatitis.

The exact causes of acute pancreatitis are unknown. The most common factors associated with the prevalent risk of acute pancreatitis are gallstones or heavy alcohol use.

Dr. Parimal Chowdhury, the lead scientist wrote, "Use of alcohol is a worldwide habit regardless of socio-economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis".

And, "The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol-induced pancreatitis".

Other risk factors found in patients with acute pancreatitis are long-term use of some medications such as Azathioprine, Thiazide, and Valproic acid, autoimmune disease, infections, trauma, metabolic disorders, and surgery.


Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of pancreatic disease, researchers examined the anti-oxidative and anti-inflammatory effects of lycopene on severe acute pancreatitis (SAP) in both in vivo and in vitro models.

According to the tested differentiation, lycopene administration protected against SAP by decreasing the levels of serum amylase and C-reactive protein associated with the inflammatory pancreas.

Lycopene also inhibited the overexpression of pro-inflammatory proteins such as The serum levels of tumor necrosis factor-α, interleukin-6, and macrophage inflammatory protein-1α.

Free radicals overexpression such as lipid peroxidase and antioxidant enzyme production such as myeloperoxidase and superoxide dismutase associated with oxidative stress was also modulated by the injection of lycopene against acinar cells in the pancreas against cells apoptosis.


In other words, lycopene protected the pancreas against the onset of acute pancreatitis in a simulated SAP model in a rat acinar cell line by inhibiting ROS.induction.

Based on the findings, researchers said, "Lycopene exerts protective effects against SAP in rats that may be related to its anti-inflammatory property through inhibiting the expression of damage-associated molecular patterns, and anti-oxidative property".

Taken together, lycopene found in tomatoes may be considered a remedy for the prevention and treatment of acute pancreatitis, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis by El-Ashmawy NE1, Khedr NF2, El-Bahrawy HA3, Hamada OB. (PubMed)
(2) Lycopene protects pancreatic acinar cells against severe acute pancreatitis by abating the oxidative stress through the JNK pathway by Lv JC1, Wang G, Pan SH, Bai XW, Sun B. (PubMed)
(3) Pathophysiology of alcoholic pancreatitis: An overview by Parimal Chowdhury and Priya Gupta. (PMC)

#Omega3 Fatty Acids Benefit Postoperative Recovery and Reduce Complications in Cancer Patients, Researchers Suggest

Kyle J. Norton

Cancer is a class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The most common cancer complications, depending on the type of cancer are
* Pain can be caused by cancer or by cancer treatment
* Fatigue.
* Difficulty breathing.
*Nausea.
*Diarrhea or constipation.
* Weight loss.
*Chemical changes in your body.
* Brain and nervous system problems.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the improvement of quality of life in cancer patients, researchers examined the omega-3 polyunsaturated fatty acids (PUFAs) effects on cancer complications
According to the medical literature* A systematic review demonstrated that a nutritional supplement enriched with fish oil decreased the symptoms of fatigue and pain in patients during chemo- and/or radiotherapy, probably due to reduced inflammatory status.

* A recent systematic review evaluated the effects of fish oil for cachexia in advanced cancer, concluding that clinical evidence is still uncertain due to a weak methodology and a large variation of fish oil dosages. However, fish oil supplementation could benefit postoperative recovery and reduce complications, such as impaired wound healing and infections.

* The plasmatic contents of omega-6/omega-3 and ALA/EPA were associated with muscle atrophy in cachectic cancer patients, indicating that these molecules may participate in the development of cancer cachexia.

* Regarding the participation of omega-3 in cancer-associated depression, it was observed that, in newly diagnosed Japanese lung cancer patients, the ALA and total omega-3 consumption was inversely associated with the development of depression.

* The application of omega-3 supplementation could be beneficial for hypercalcemia-associated bone resorption because it was observed that, in an animal model of apical periodontitis, omega-3 supplementation reduced bone resorption by the downregulation of the inflammatory cells influx.

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of cancer-related complications, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications by Freitas RDS1,2, Campos MM. (PubMed)

#Omega3 Fatty Acids Induce Weight Loss in Obese with Type 2 Diabetes Under a Caloric-Restriction Regimen, Researchers Say

Kyle J. Norton

Today, the prevalence of extremely overweight and obese children caused by an unhealthy diet and lifestyle change over 2 decades of economic prosperity, in the Southeast Asian population has raised concerns in the scientific community,
Overweight and obesity have reached epidemic proportions in many countries, affecting even younger age populations and inducing an economic burden in the healthcare system for the treatment of obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1).

Obesity is a chronic medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.

Weight loss is a process that intentionally reduces the total body mass, through the decrease of fluid, body fat or adipose tissue or lean mass.

Due to the widespread obesity in North America (over 68% of the US population is either overweight or obese), many weight loss products were created by manufacturers.


Weight loss products is a 66 billion business in the US, according to the statistic provided by the Marketdata LLC research firm. And the business continues to grow at a rapid rate.

Are the weight loss products work? I don't think so. Otherwise, the percentage of the overweight population in the US should be decreased substantially.

In other words, all weight loss products may have a complex structure or a long-term commitment before the results can be seen.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the treatment of chronic diseases associated with obesity, researchers examined the relationship between levels of serum eicosapentaenoic acid (EPA), arachidonic acid (AA), as well as EPA/AA ratio and weight loss during hospitalization in participants considered to be overweight, with type 2 diabetes.

The study included 142 patients who were hospitalized for treatment of type 2 diabetes and divided into two groups depending on the achievement in the reduction of body weight by 3% or more during hospitalization.

According to the tested analysis,
* After the adjustment was made for several confounders, the hazard ratio of effective weight loss for logarithmical serum EPA was 1.59 (95% CI 1.02-2.49, P = 0.04) and for logarithmical EPA/AA ratio 1.64 (1.03-2.61, P = 0.04), whereas the hazard ratio for effective weight loss for logarithmical serum AA was 1.11 (0.45-2.78, P = 0.82).

* Furthermore, after dividing EPA/AA ratio and serum EPA into quartiles based on participant number, the hazard ratio for the highest quartile of EPA/AA ratio was 2.33 for the highest quartile of serum EPA 1.60 (0.80-3.19, P = 0.18) compared with the lowest quartile.


More precisely, EPA is involved in body weight change under a caloric-restriction regimen.

In other words, a high serum level of EPA, relative to the level of AA, can lead to a reduction of adipose tissue weight through the anti-inflammatory effects of EPA.


Based on the finding, researchers said, " EPA/AA ratio was found to be a better predictor of medical intervention for weight loss among overweight patients with type 2 diabetes, compared with serum EPA level".

Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for inducing weight loss, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Eicosapentaenoic acid/arachidonic acid ratio and weight loss during hospitalization for glycemic control among overweight Japanese patients with type 2 diabetes: a retrospective observational study by Nakanishi S1, Hirukawa H2, Shimoda M2, Tatsumi F2, Kohara K2, Obata A2, Okauchi S2, Kinoshita T2, Sanada J2, Fushimi Y2, Nishioka M2, Kan Y2, Tomita A2, Mashiko A2, Horiya M2, Iwamoto Y2, Mune T2, Kaku K3, Kaneto H. (PubMed)
(2) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)

6-hydroxy-1-methylindole-3-acetonitrile (6-HMA) Isolated From #Brassicarapa Inhibits #Oxidativestress and Inflammation Associated with Oxidative Nephrotoxicity Induced by Cisplatin in Vitro and Vivo

Kyle J. Norton

Kidneys are 2 bean-shaped organs found on the left and right side of the retroperitoneal space in the body.
The function of the kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.

Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.

Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.

Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.

Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.

The disease is caused by the poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.

According to the American physician association, long-term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs, and rifampicin are associated to increase damage to the kidney.

And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.

Oxidative nephrotoxicity is a condition of kidney damage caused by overexpression of free radicals compared to levels of antioxidants.

Dr. Keiko Hosohata in the examination "Role of Oxidative Stress in Drug-Induced Kidney Injury",
Said, "Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury".


And "In fact, drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20% of cases of acute kidney injury (AKI) among hospitalized patients".


Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of kidney diseases, researchers examined the nephroprotective effects of 6-HMA  on oral cavity oxidative stress and inflammation,, which was isolated from the roots of B. rapa, on cisplatin-induced toxicity in renal epithelial LLC-PK1 cells and in rats with acute renal injury

The study included 16subjects that were randomized, and fifteen subjects completed all visits.

According to the tested analysis, in vitro and Vivo
* The pretreatment of LLC-PK1 cells with 6-HMA ameliorated cisplatin-induced cytotoxicity caused by oxidative stress.

* The pretreatment also decreased the levels of reactive oxygen species (ROS) and kidney stress marker malondialdehyde (MDA) and increased levels of glutathione (GSH).

* Furthermore, 6-HMA inhibited cisplatin-induced heme oxygenase-1 (HO-1) expression involved in oxidation and inflammation by the binding activity of NF-E2-related factor 2 (Nrf2), the antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.

* Moreover, 6-HMA-administered rats showed lower levels of blood urea nitrogen (BUN), creatinine, and urinary lactate dehydrogenase (LDH) associated with kidney damage than cisplatin alone-treated rats in the cisplatin-induced renal injury model.

* Additionally, 6-HMA inhibited the cisplatin-induced formation of MDA and GSH depletion and increased the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR).


Based on the results, researchers wrote, " these findings indicate 6-HMA is a major active constituent from the roots of B. Rapa to have a protective effect against cisplatin-induced nephrotoxicity by attenuating oxidative stress.".

Taken altogether, Brassica rapa processed abundantly 6-HMA may be considered supplements for the prevention of oxidative nephrotoxicity, pending the confirmation of the larger sample size and multicenter human study.


Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation by Moon JH1, Shin JS, Kim JB, Baek NI, Cho YW, Lee YS, Kay HY, Kim SD, Lee KT. (PubMed)
(2) Role of Oxidative Stress in Drug-Induced Kidney Injury by Keiko Hosohata. (PMC)

#GreenTea and Its EGCG Improve #OralHealth by Inhibiting Bactertal Growth Associated with Oral Cavity Oxidative Stress and Inflammation,, According to Studies

Kyle J. Norton

Green tea is found to consist a potential effect in the promotion of oral health against bacterial-induced tooth decay or cavities, a renowned institute suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including lack of energy, weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the Technion-Israel Institute of Technology, Polyphenols including epigallocatechin 3 gallate (EGCG) isolated from green tea ameliorated oral cavity oxidative stress and inflammation, cigarette smoking and cigarettes' deleterious compounds nicotine and acrolein.


Dr. Narotzki B, the lead author of the study said, " Generally, green tea defends healthy cells from malignant transformation and locally has the ability to induce apoptosis in oral cancer cells. Altogether, there is an increasing interest in the health benefits of green tea in the field of oral health".


In the review of beneficial effects of green tea on oral disease, researchers found that green tea not only reduced the bacterial activity in the oral cavity in the expression of the aforementioned oral afflictions but also attenuated the risk of oral cancer through the antioxidant activities.

EGCG, in Solobacterium, moorei, a volatile sulfide compound (VSC)-producing Gram-positive anaerobic bacterium study, displayed a significant effect in inhibiting the growth of S. moorei, with MIC values of 500 and 250 μg/ml resulting in reduced the adherence of S. moorei to oral epithelial cells.

The study also suggested the efficacy of green tea extract and EGCG protected oral health by inhibited the progression of Solobacterium moorei probably through the ameliorated S. moorei's β-galactosidase activity in the production of volatile sulfide compound (VSC) in doses dependent manner.

Green tea with abundant natural compounds may be the next generation of whole food used as a therapeutic supplement in promoted oral healthcare.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Sources
(1) Green tea: a promising natural product in oral health by Narotzki B1, Reznick AZ, Aizenbud D, Levy Y.(PubMed)
(2) Green Tea (Camellia Sinensis): Chemistry and Oral Health by Khurshid Z1, Zafar MS2, Zohaib S3, Najeeb S4, Naseem M5.(PubMed)
(3) Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of Solobacterium moorei by Morin MP1, Bedran TB2, Fournier-Larente J3, Haas B4, Azelmat J5, Grenier D6.(PubMed)