Kyle J. Norton
Hypertension, hyperglycemia, and hyperlipidemia are the most prevalent modifiable risk factors for the development of diabetes, cardiovascular diseases, and stroke.
Intake of dried pea and bean fibers daily and regularly may reduce risk and treatment of hypertension, Hyperlipidemia and Hyperglycemia, some scientists suggested.
The dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with a healthy source of proteins, fibers, vitamins, and minerals.
1. The Effects of Dried Peas and Hypertension
Hypertension is a chronic condition characterized by abnormally high blood pressure.
According to the Veterans Affairs Medical Center, daily intake of fiber has emerged not only to prevent and treat various types of chronic diseases. but also reducing the risk of hypertension.
Dr. Anderson JW, the lead author said, "Dried beans, oat products, and certain fruits and vegetables are good sources of soluble fiber" and "Current guidelines advise a doubling of dietary fiber intake for Americans. Inclusion of ample servings of fruits and vegetables, whole grains, and dried beans and peas will help individuals meet these guidelines".
Additionally, in the examined mineralocorticoid excess-treated mice with a control diet, high-fiber diet, or acetate supplementation researcher found that high fiber diet not only modified the gut microbiota populations and also increased the abundance of acetate-producing bacteria independently of mineralocorticoid excess and reduced systolic and diastolic blood pressures.
Dr. Marques FZ, the lead researcher said, "The favorable effects of fiber may be explained by the generation and distribution of one of the main metabolites of the gut microbiota, the short-chain fatty acid acetate. Acetate effected several molecular changes associated with improved cardiovascular health and function".
These results demonstrated a significant effect of fiber intake in promoted health gut microbiota in regulating molecular changes associated with improved risk factors related to cardiovascular health and function, including blood pressure.
Other, in the examined cross-sectional studies of dietary intake as one of the major determinants in hypertension development and Dietary Approach to Stop Hypertension and the risk of incident hypertension in a large cohort study including the incidence of hypertension among 80 426 French adults, researchers at the joint study led by the Paris-Descartes University found that
1. During a mean follow-up of 3.4±2.1 years, 2413 cases of incident hypertension were documented
2. Fiber intake displayed a strong effect in reduced risk of hypertension with relative odd risk of 0.81 in compared to the baseline.
3. Adopting a global healthy diet associated with several nutritional factors intake may be one of the best solutions for reducing hypertensive incidence.
2. The Effects of Dried Peas on Hyperlipidemia
Hyperlipidemia is a condition characterized by high levels of cholesterol in the bloodstream.
In a study of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomized assigned to a high-fiber bean-rich diet that achieved mean (SD) fiber intakes of 35.5 (18.6) g day for women and 42.5 (30.3) g day for men, or a low-carbohydrate diet, researchers found that
1. High bean fiber intake showed better weight loss and weight control compared to the low carbohydrate diet group.
2. Intake of bean fiber group expressed a significant decrease of Low-density lipoprotein (LDL)-cholesterol and total cholesterol levels compared to the other group.
Dr. Tonstad S, the lead author said, "A high-fibre bean-rich diet was as effective as a low-carbohydrate diet for weight loss, although only the bean-rich diet lowered atherogenic lipids".
Additionally, in dyslipidemia rats study to evaluate the effects of grain-bean package, dietary fiber (DF) extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase (FAS) activity in high-fat, high-cholesterol feeding by randomly assigned into normal control group, hyperlipidemia model group, grain-bean package group, grain-bean package DF group and grain corn group, researchers after adjusting to other risk factors filed the following results
1. Rats in the hyperlipidemic model group showed increased total cholesterol (TC), triglyceridaemia (TG), high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose (FBG) compared to groups
2. Compared to the hyperlipidemic model group, the grain-bean package group, grain-bean package DF group, expressed significantly decreased total cholesterol (TC), triglyceridaemia (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose, and significantly increased HDL-C levels.
The results of these findings demonstrated that dietary fiber can improve blood lipids levels in dyslipidemic subjects, decrease FAS activity and regulate SREBP-1c mRNA in glucose metabolic expression.
3. The Effects of Dried Peas on Hyperglycemia
Hyperglycemia is a medical condition characterized by abnormal high levels of glucose circulated in the bloodstream.
Dried peas, a good sources of protein and fiber, is one of many rich-protein recommended for vegetarian.
Together with a low glycemic index, peas may be considered a high-fiber food for daily carbohydrate intake in prediabetes.
Evidences of studies showed that a low-glycemic load meal containing psyllium soluble fiber is significantly improves the breakfast postprandial glycemic, insulinemic in adults with Type 2 DM.
In the study to compare the glycemic and insulinemic responses to 3 different meals based on dried peas, potatoes, or both in patients with type 2 diabetes, intake of the pea meal expressed a significant intine delay of the increased postprandial plasma glucose and insulin concentrations, compared to other meal.
Since carbohydrates counting in dried peas have been disregarded, the nutrient dried peas should be included in the consumption of low-glycemic, high-fiber foods at the expense of high-glycemic, low-fiber foods for prediabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Health benefits and practical aspects of high-fiber diets by Anderson JW1, Smith BM, Gustafson NJ.(PubMed)
(2) High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice by Marques FZ1, Nelson E2, Chu PY2, Horlock D2, Fiedler A2, Ziemann M2, Tan JK2, Kuruppu S2, Rajapakse NW2, El-Osta A2, Mackay CR2, Kaye DM1(PubMed)
(3) Individual and Combined Effects of Dietary Factors on Risk of Incident Hypertension: Prospective Analysis From the NutriNet-Santé Cohort by Lelong H1, Blacher J2, Baudry J1, Adriouch S1, Galan P1, Fezeu L1, Hercberg S1, Kesse-Guyot E1.(PubMed)(4) A high-fiber bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(5) [Effect of grain-bean package, grain-bean package dietary fiber, and single whole grain dietary fiber on dyslipidemia rats].[Article in Chinese] by Liu Y, Zhai C, Sun G, Zhang H, Jiang M, Zhang H, Guo J, Lan X.(PubMed)
(6) Evaluation of a high-fiber diet in hyperlipidemia: a review by Ullrich IH.(PubMed)(7) Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus by Clark CA, Gardiner J, McBurney MI, Anderson S, Weatherspoon LJ, Henry DN, Hord NG.(PubMed)
(8) Comparison of the effects of dried peas with those of potatoes in mixed meals on postprandial glucose and insulin concentrations in patients with type 2 diabetes by Schäfer G, Schenk U, Ritzel U, Ramadori G, Leonhardt U.(PubMed)
Wednesday, 12 July 2023
#BetaSitostero May Process #EstrogenicEffects #Phytochemicals, According to Studies
Kyle J. Norton
Estrogen is a primary female sex hormone, responsible for the development and regulation of the female reproductive system and secondary sex characteristics. The estrogenic effect is an action that stimulates the production of the hormone estrogen in case of deficiency.
On the other hand, the anti-estrogenic effect is an action of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulating in the body.
Menopause is a condition in which a woman is in the transition stage of permanent cessation of the ovary's functions in egg production because of less production of estrogen and progesterone, signaling the end of the reproductive phase of a woman's life.
In menopause, menstruation has become irregular and slowly stops over time, but in some women, menstrual flow comes to a sudden halt.
Some researchers suggested that you officially enter the stage of menopause if you have gone 12 months without a menstrual period.
Menopause symptoms are a set of symptoms caused by the gradual decline of levels of estrogen and progesterone due to aging loss of menstrual periods in women.
The reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, and pelvic muscles normally regulated by the hormone estrogen also are affected by the declining levels of the hormone.
In the concern of hormone therapy used for the treatment of menopause symptoms, herbal medicine with estrogenic effect have been under intensive investigation, with an aim to find a natural ingredient with similar effects as those used in hormone therapy with no side effects.
The aim of estrogenic therapy is to relieve symptoms of sleep interruption, according to the study of health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors, and menopausal symptoms, primarily hot flashes, affect approximately two-thirds of menopausal and postmenopausal women, botanicals and dietary supplement (BDS).
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.
In finding a potential phytochemical for the prevention and treatment of menopausal symptoms, researchers elucidated the effects of β-sitosterol and stigmasterol in the hydroalcoholic extract of Bambusa bambos as an alternative Hormone Replacement Therapy.
According to the results of the experiment
* The extract containing β-sitosterol and stigmasterol showed an estrogenic effect on the growth of MCF-7 cells in vitro.
* The tested extract showed no cytotoxicity to MCF-7 cells in any of the dilutions, but induced cell proliferation, and all the dilutions except <500μg/ml have significantly increased cell multiplication.
* Furthermore, the doses of 15.6, 31.2, 62.5, and 125μg/ml of HEBB have shown an influence on the proliferation rates similar to the standard 17β-estradiol.
Based on the findings, researchers said, "The results suggest that HEBB might be used as a safe alternative to estrogen replacement therapies".
Beta-Sitosterol may be considered a natural estrogenic remedy for the prevention and treatment of menopausal symptoms, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Identification of beta-sitosterol and stigmasterol in Bambusa bambos (L.) Voss leaf extract using HPLC and its estrogenic effect in vitro by Sriraman S1, Ramanujam GM1, Ramasamy M1, Dubey GP. (PubMed)
Estrogen is a primary female sex hormone, responsible for the development and regulation of the female reproductive system and secondary sex characteristics. The estrogenic effect is an action that stimulates the production of the hormone estrogen in case of deficiency.
On the other hand, the anti-estrogenic effect is an action of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulating in the body.
Menopause is a condition in which a woman is in the transition stage of permanent cessation of the ovary's functions in egg production because of less production of estrogen and progesterone, signaling the end of the reproductive phase of a woman's life.
In menopause, menstruation has become irregular and slowly stops over time, but in some women, menstrual flow comes to a sudden halt.
Some researchers suggested that you officially enter the stage of menopause if you have gone 12 months without a menstrual period.
Menopause symptoms are a set of symptoms caused by the gradual decline of levels of estrogen and progesterone due to aging loss of menstrual periods in women.
The reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, and pelvic muscles normally regulated by the hormone estrogen also are affected by the declining levels of the hormone.
In the concern of hormone therapy used for the treatment of menopause symptoms, herbal medicine with estrogenic effect have been under intensive investigation, with an aim to find a natural ingredient with similar effects as those used in hormone therapy with no side effects.
The aim of estrogenic therapy is to relieve symptoms of sleep interruption, according to the study of health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors, and menopausal symptoms, primarily hot flashes, affect approximately two-thirds of menopausal and postmenopausal women, botanicals and dietary supplement (BDS).
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.
In finding a potential phytochemical for the prevention and treatment of menopausal symptoms, researchers elucidated the effects of β-sitosterol and stigmasterol in the hydroalcoholic extract of Bambusa bambos as an alternative Hormone Replacement Therapy.
According to the results of the experiment
* The extract containing β-sitosterol and stigmasterol showed an estrogenic effect on the growth of MCF-7 cells in vitro.
* The tested extract showed no cytotoxicity to MCF-7 cells in any of the dilutions, but induced cell proliferation, and all the dilutions except <500μg/ml have significantly increased cell multiplication.
* Furthermore, the doses of 15.6, 31.2, 62.5, and 125μg/ml of HEBB have shown an influence on the proliferation rates similar to the standard 17β-estradiol.
Based on the findings, researchers said, "The results suggest that HEBB might be used as a safe alternative to estrogen replacement therapies".
Beta-Sitosterol may be considered a natural estrogenic remedy for the prevention and treatment of menopausal symptoms, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Identification of beta-sitosterol and stigmasterol in Bambusa bambos (L.) Voss leaf extract using HPLC and its estrogenic effect in vitro by Sriraman S1, Ramanujam GM1, Ramasamy M1, Dubey GP. (PubMed)
The Anti-#BreastCancer Whole Foods, According to Studies
Kyle J. Norotn
The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer is widespread in women in Southeast Asia as a result of over 2 decades of economic prosperity caused by an unhealthy diet is a major concern.
The findings for effective treatments are ongoing with some successes, but discovering effective prevention and treatment with little or no side effects has proven difficultly.
According to statistics, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Suggestions of a healthy diet with plenty of vegetables and fruits(1)(2)(3) with a change of lifestyle (4)(5)(6) may be the only choice for women in reducing the risk of the diseases.
1. Black Rice
Black Rice is a type of rice with enriched Anthocyanins. including Indonesian black rice and Thai jasmine black rice, considered one of nature's superfoods with various antioxidants.
Anthocyanins in black rice, oral administration of AEBR (100 mg/kg/day) to BALB/c nude mice bearing MDA-MB-453 cell xenografts significantly suppressed tumor growth and angiogenesis by suppressing the expression of the physiological process factors MMP-9MMP-2(enzymes involved in the breakdown of extracellular matrix), and uPA(activator) in tumor tissue.
AEBR also induced human breast cancer cells by inducing apoptosis and suppressing angiogenesis(37)(38).
Other chemical constituents of species of black glumed’ Njavara (Oryza sativa L.) isolation, namely, flavonolignans, tricin 4'-O-(erythro-β-guaiacylglyceryl) ether (compound 1), and tricin 4'-O-(threo-β-guaiacylglyceryl) ether (compound 2), also inhibited breast cancer cell line MCF-7, by inducing apoptosis at concentration 40 and 30 μg/ and chromatin condensation by decreasing protein in the mitochondrial membrane(39).
2. Green tea
Green tea contains more amount of antioxidants than any drink or food with the same volume is the leaves of Camellia sinensis, which undergo minimal oxidation during processing and originated from China.
Regular green tea intake is associated with an inverse risk of breast cancer, as green tea enhanced the production of Ki-67, a cancer antigen compared to non-drinkers. (63).
(-)-epigallocatechin gallate, a phytochemical in green tea exert its epigenetic effects in altering the DNA methyltransferase expression in many types of cancer, including breast cancer(64).
Catechins, another phytochemical of green tea, inhibited the proliferation of breast cancer cells and blocked carcinogenesis in breast cancer probably through the expression of translocation across membranes or for degradation, ribonucleoprotein DNA reduplication, apoptotic cascade, etc.(65).
In inflammatory breast cancer, a most aggressive type of breast cancer, green tea polyphenol epigallocatechin-3-gallate (EGCG), decreased expression of genes in promoted proliferation, migration, invasion, and survival in human breast cancer cell lines, SUM-149 and SUM-190 by reduced lymphangiogenesis-promoting genes(66) and inhibited the cell proliferation at 72 hours, after 10 microM of EGCG treatment.
These suggested green tea induced a reactivation of apoptosis, probably through the complexity of the angiogenic switch which can lead to the modulation of the cell migration processes against triple-negative breast cancer cells (67).
In human breast cancer MCF-7 cells, selenium-containing polysaccharides (Se-GTPs) from a new variety of selenium-enriched Ziyang green tea, in dose-dependent, exhibited an effective cell growth inhibition by inducing MCF-7 cancer cells to undergo G2/M(cell cycle) phase arrest and apoptosis by up-regulation of p53 (tumor antigen) expression(68).
Unfortunately, epidemiological data, on the incidence of breast cancer and the recurrence of breast cancer, consumption of 5 or more cups of green tea a day showed a non-statistically significant trend towards the prevention of breast cancer development. But some evidence indicated that green tea consumption may possibly help prevent breast cancer recurrence in early-stage (I and II) cancers(69).
3. Red wine
Red wine, made from the pigments of grape varieties is a wine that involved the extraction of color, and flavour components from the grape skin.
Red wine phenolics piceatannol and myricetin reduced the proliferation of estrogen hormone-dependent breast cancer cells by binding to the gene expression of estrogen receptor (ER) alpha, which interacts with responsive DNA sequences located within the promoter region of target genes(70).
Catechin hydrate (CH), an antioxidant in red wine, induced apoptosis against MCF-7 cells, with a rate of 40.7% and 41.16% in the volume of 150 μg/ml CH in 24 hours, respectively.
Moreover, a 48-hour exposure to 150 μg/ml CH and 300 μg/ml CH resulted in 43.73% and 52.95% apoptotic cells, through increased expression of pro-apoptotic genes such as caspase-3, -8, and -9 and TP53(71).
4. Black bean
Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae. It is believed that the black bean was the first domesticated growth in South America.
Water-soluble condensed tannins isolated from black beans inhibited breast cancer cell line MCF-7 at 24 microM by suppresseing a fetal bovine serum (blood fraction remaining after the natural coagulation of blood) stimulated cell migration and the secretion of matrix metalloproteinase-2 (MMP-2 or gelatinase A), matrix metalloproteinase-9 (MMP-9 or gelatinase B)(involved in the breakdown of extracellular matrix), and vascular endothelial growth factor VEGF(165)(regulator of angiogenesis) receptors expression(72).
The phytochemical of black bean (Phaseolus vulgaris) seed coats, also enhanced potent antioxidant and anti-proliferative activities against MCF-7 human breast cancer cells in doses depending on manner(73).
5. Fermented soybean
Fermented soybean made from ground soybeans, is a popular ingredient used in the cuisines of East and Southeast Asia.
Chungkookjang, a Korean fermented soybean, containing a high concentration of isoflavones and peptides inhibited the growth of breast cancer MCF7 cells in decreased dependent on the concentration by activating the TGFβ pathway in cellular processes and depressing inflammation(74).
In murine breast adenocarcinoma, fermented soy products (FSP) are effective in tumor containment with the smallest tumor volumes. (75).
6. Peanut
Peanuts, belonging to the the legume related to the bean family is first cultivated in the in the Chaco region of Paraguay and Bolivia.
Lectin ( (PNA), a chemical constituent of peanut was effective in inhibiting the proliferation of human breast cell lines (ZR-75.1 and 734-B)(76) and MCF-7, T 47D, HBL 100, BT 20(77).
Beta-Sitosterol found in legumes, oil seeds, and unrefined plant oils such as peanut butter, pistachios, and sunflower, exhibited the extrinsic apoptotic programmed cell death pathway in human breast MCF-7 and MDA-MB-231(78).
7. Faxseed
Flax seed also known as common flax or linseed is native to the region of the eastern Mediterranean to India.
A study of athymic mice fed with basal diet (control), or 10% FS diet, with or without TRAS (2.5mg/kg) for 5 wk, displayed positive effects in reduced tumor size and increased tumor apoptosis.
Dietary FS improved the function of TRAS in increased overall survival(79).
Dietary flaxseed lignan or oil combined with tamoxifen reduced the growth of estrogen receptor-positive breast tumors (MCF-7) at low circulating estrogen levels by inhibiting cell proliferation, expression of genes, and proteins involved in the ER- and growth factor-mediated signaling pathways(80).
FO induced greatest effect in increasing apoptosis in compared with TAM treatment alone(80).
Lignans (a class of phytoestrogens) consumption was associated with a significant reduction in breast cancer risk(81).
In estrogen-receptor-positive (MCF-7) and estrogen-receptor-negative (MDA-MB-231) cells, Flaxseed sprouts induced apoptosis and inhibited cancer cell growth by significantly upregulated p53(Anti-tumor antigen) mRNA (transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell) in both cell cancer lines(82).
Taken together, certain vegetables(7)(8) and fruits(9)(10) or their chemical compounds may heave a potential and therapeutic effect in the treatment of breast cancer, by blocking the cancer energy sources of the pathways, influencing the signal pathways of the cell proliferation or suppressing the promoted cancers genes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC. (PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA. (PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME. (PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with the consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce an intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(63) logical effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients by Yu SS, Spicer DV, Hawes D, Tseng CC, Yang CS, Pike MC, Wu AH(PubMed)
(64) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(65) Green Tea Catechins: Proposed Mechanisms of Action in Breast Cancer Focusing on The Interplay Between Survival and Apoptosis by Yiannakopoulou EC. (PubMed)
(66)Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells by Mineva ND, Paulson KE, Naber SP, Yee AS, Sonenshein GE. (PubMed)
(67) Epigallocatechin-3-Gallate (EGCG) inhibits cell proliferation and migratory behaviour of triple-negative breast cancer cells by Braicu C, Gherman CD, Irimie A, Berindan-Neagoe I.(PubMed)
(68) Inhibitory effects and molecular mechanisms of selenium-containing tea polysaccharides on human breast cancer MCF-7 cells by He N, Shi X, Zhao Y, Tian L, Wang D, Yang X.(PubMed)
(69) The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis by Seely D, Mills EJ, Wu P, Verma S, Guyatt GH. (PubMed)
(70) The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor alpha in human breast cancer cells by Maggiolini M, Recchia AG, Bonofiglio D, Catalano S, Vivacqua A, Carpino A, Rago V, Rossi R, Andò S.(PubMed)
(71) Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. by Alshatwi AA.(PubMed)
(72) Inhibition of Caco-2 colon, MCF-7, and Hs578T breast, and DU 145 prostatic cancer cell proliferation by water-soluble black bean condensed tannins by Bawadi HA, Bansode RR, Trappey A 2nd, Truax RE, Losso JN.(PubMed)
(73) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M, He X, Liu RH. (PubMed)
(74) Inflammation-related signaling pathways implicating TGFβ are revealed in the expression profiling of MCF7 cell treated with fermentedsoybean, chungkookjang by Hwang JS, Yoo HJ, Song HJ, Kim KK, Chun YJ, Matsui T, Kim HB.(PubMed)
(75) A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma by Kinouchi FL, Maia DC, de Abreu Ribeiro LC, Placeres MC, de Valdez GF, Colombo LL, Rossi EA, Carlos IZ. (PubMed)
(76) Peanut agglutinin inhibits proliferation of cultured breast cancer cells by Marth C, Daxenbichler G.(PubMed)
(77) The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro by Valentiner U, Fabian S, Schumacher U, Leathem AJ. (PubMed)
(78) beta-Sitosterol activates Fas signaling in human breast cancer cells by Awad AB, Chinnam M, Fink CS, Bradford PG. (PubMed)
(79) Dietary flaxseed-trastuzumab interactive effects on the growth of HER2-overexpressing human breast tumors (BT-474) by Mason JK, Fu MH, Chen J, Yu Z, Thompson LU. (PubMed)
(80) Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways by Saggar JK, Chen J, Corey P, Thompson LU. (PubMed)
(81)Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk by Lowcock EC, Cotterchio M, Boucher BA. (PubMed)
The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer is widespread in women in Southeast Asia as a result of over 2 decades of economic prosperity caused by an unhealthy diet is a major concern.
The findings for effective treatments are ongoing with some successes, but discovering effective prevention and treatment with little or no side effects has proven difficultly.
According to statistics, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Suggestions of a healthy diet with plenty of vegetables and fruits(1)(2)(3) with a change of lifestyle (4)(5)(6) may be the only choice for women in reducing the risk of the diseases.
1. Black Rice
Black Rice is a type of rice with enriched Anthocyanins. including Indonesian black rice and Thai jasmine black rice, considered one of nature's superfoods with various antioxidants.
Anthocyanins in black rice, oral administration of AEBR (100 mg/kg/day) to BALB/c nude mice bearing MDA-MB-453 cell xenografts significantly suppressed tumor growth and angiogenesis by suppressing the expression of the physiological process factors MMP-9MMP-2(enzymes involved in the breakdown of extracellular matrix), and uPA(activator) in tumor tissue.
AEBR also induced human breast cancer cells by inducing apoptosis and suppressing angiogenesis(37)(38).
Other chemical constituents of species of black glumed’ Njavara (Oryza sativa L.) isolation, namely, flavonolignans, tricin 4'-O-(erythro-β-guaiacylglyceryl) ether (compound 1), and tricin 4'-O-(threo-β-guaiacylglyceryl) ether (compound 2), also inhibited breast cancer cell line MCF-7, by inducing apoptosis at concentration 40 and 30 μg/ and chromatin condensation by decreasing protein in the mitochondrial membrane(39).
2. Green tea
Green tea contains more amount of antioxidants than any drink or food with the same volume is the leaves of Camellia sinensis, which undergo minimal oxidation during processing and originated from China.
Regular green tea intake is associated with an inverse risk of breast cancer, as green tea enhanced the production of Ki-67, a cancer antigen compared to non-drinkers. (63).
(-)-epigallocatechin gallate, a phytochemical in green tea exert its epigenetic effects in altering the DNA methyltransferase expression in many types of cancer, including breast cancer(64).
Catechins, another phytochemical of green tea, inhibited the proliferation of breast cancer cells and blocked carcinogenesis in breast cancer probably through the expression of translocation across membranes or for degradation, ribonucleoprotein DNA reduplication, apoptotic cascade, etc.(65).
In inflammatory breast cancer, a most aggressive type of breast cancer, green tea polyphenol epigallocatechin-3-gallate (EGCG), decreased expression of genes in promoted proliferation, migration, invasion, and survival in human breast cancer cell lines, SUM-149 and SUM-190 by reduced lymphangiogenesis-promoting genes(66) and inhibited the cell proliferation at 72 hours, after 10 microM of EGCG treatment.
These suggested green tea induced a reactivation of apoptosis, probably through the complexity of the angiogenic switch which can lead to the modulation of the cell migration processes against triple-negative breast cancer cells (67).
In human breast cancer MCF-7 cells, selenium-containing polysaccharides (Se-GTPs) from a new variety of selenium-enriched Ziyang green tea, in dose-dependent, exhibited an effective cell growth inhibition by inducing MCF-7 cancer cells to undergo G2/M(cell cycle) phase arrest and apoptosis by up-regulation of p53 (tumor antigen) expression(68).
Unfortunately, epidemiological data, on the incidence of breast cancer and the recurrence of breast cancer, consumption of 5 or more cups of green tea a day showed a non-statistically significant trend towards the prevention of breast cancer development. But some evidence indicated that green tea consumption may possibly help prevent breast cancer recurrence in early-stage (I and II) cancers(69).
3. Red wine
Red wine, made from the pigments of grape varieties is a wine that involved the extraction of color, and flavour components from the grape skin.
Red wine phenolics piceatannol and myricetin reduced the proliferation of estrogen hormone-dependent breast cancer cells by binding to the gene expression of estrogen receptor (ER) alpha, which interacts with responsive DNA sequences located within the promoter region of target genes(70).
Catechin hydrate (CH), an antioxidant in red wine, induced apoptosis against MCF-7 cells, with a rate of 40.7% and 41.16% in the volume of 150 μg/ml CH in 24 hours, respectively.
Moreover, a 48-hour exposure to 150 μg/ml CH and 300 μg/ml CH resulted in 43.73% and 52.95% apoptotic cells, through increased expression of pro-apoptotic genes such as caspase-3, -8, and -9 and TP53(71).
4. Black bean
Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae. It is believed that the black bean was the first domesticated growth in South America.
Water-soluble condensed tannins isolated from black beans inhibited breast cancer cell line MCF-7 at 24 microM by suppresseing a fetal bovine serum (blood fraction remaining after the natural coagulation of blood) stimulated cell migration and the secretion of matrix metalloproteinase-2 (MMP-2 or gelatinase A), matrix metalloproteinase-9 (MMP-9 or gelatinase B)(involved in the breakdown of extracellular matrix), and vascular endothelial growth factor VEGF(165)(regulator of angiogenesis) receptors expression(72).
The phytochemical of black bean (Phaseolus vulgaris) seed coats, also enhanced potent antioxidant and anti-proliferative activities against MCF-7 human breast cancer cells in doses depending on manner(73).
5. Fermented soybean
Fermented soybean made from ground soybeans, is a popular ingredient used in the cuisines of East and Southeast Asia.
Chungkookjang, a Korean fermented soybean, containing a high concentration of isoflavones and peptides inhibited the growth of breast cancer MCF7 cells in decreased dependent on the concentration by activating the TGFβ pathway in cellular processes and depressing inflammation(74).
In murine breast adenocarcinoma, fermented soy products (FSP) are effective in tumor containment with the smallest tumor volumes. (75).
6. Peanut
Peanuts, belonging to the the legume related to the bean family is first cultivated in the in the Chaco region of Paraguay and Bolivia.
Lectin ( (PNA), a chemical constituent of peanut was effective in inhibiting the proliferation of human breast cell lines (ZR-75.1 and 734-B)(76) and MCF-7, T 47D, HBL 100, BT 20(77).
Beta-Sitosterol found in legumes, oil seeds, and unrefined plant oils such as peanut butter, pistachios, and sunflower, exhibited the extrinsic apoptotic programmed cell death pathway in human breast MCF-7 and MDA-MB-231(78).
7. Faxseed
Flax seed also known as common flax or linseed is native to the region of the eastern Mediterranean to India.
A study of athymic mice fed with basal diet (control), or 10% FS diet, with or without TRAS (2.5mg/kg) for 5 wk, displayed positive effects in reduced tumor size and increased tumor apoptosis.
Dietary FS improved the function of TRAS in increased overall survival(79).
Dietary flaxseed lignan or oil combined with tamoxifen reduced the growth of estrogen receptor-positive breast tumors (MCF-7) at low circulating estrogen levels by inhibiting cell proliferation, expression of genes, and proteins involved in the ER- and growth factor-mediated signaling pathways(80).
FO induced greatest effect in increasing apoptosis in compared with TAM treatment alone(80).
Lignans (a class of phytoestrogens) consumption was associated with a significant reduction in breast cancer risk(81).
In estrogen-receptor-positive (MCF-7) and estrogen-receptor-negative (MDA-MB-231) cells, Flaxseed sprouts induced apoptosis and inhibited cancer cell growth by significantly upregulated p53(Anti-tumor antigen) mRNA (transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell) in both cell cancer lines(82).
Taken together, certain vegetables(7)(8) and fruits(9)(10) or their chemical compounds may heave a potential and therapeutic effect in the treatment of breast cancer, by blocking the cancer energy sources of the pathways, influencing the signal pathways of the cell proliferation or suppressing the promoted cancers genes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC. (PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA. (PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME. (PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with the consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce an intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(63) logical effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients by Yu SS, Spicer DV, Hawes D, Tseng CC, Yang CS, Pike MC, Wu AH(PubMed)
(64) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(65) Green Tea Catechins: Proposed Mechanisms of Action in Breast Cancer Focusing on The Interplay Between Survival and Apoptosis by Yiannakopoulou EC. (PubMed)
(66)Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells by Mineva ND, Paulson KE, Naber SP, Yee AS, Sonenshein GE. (PubMed)
(67) Epigallocatechin-3-Gallate (EGCG) inhibits cell proliferation and migratory behaviour of triple-negative breast cancer cells by Braicu C, Gherman CD, Irimie A, Berindan-Neagoe I.(PubMed)
(68) Inhibitory effects and molecular mechanisms of selenium-containing tea polysaccharides on human breast cancer MCF-7 cells by He N, Shi X, Zhao Y, Tian L, Wang D, Yang X.(PubMed)
(69) The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis by Seely D, Mills EJ, Wu P, Verma S, Guyatt GH. (PubMed)
(70) The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor alpha in human breast cancer cells by Maggiolini M, Recchia AG, Bonofiglio D, Catalano S, Vivacqua A, Carpino A, Rago V, Rossi R, Andò S.(PubMed)
(71) Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. by Alshatwi AA.(PubMed)
(72) Inhibition of Caco-2 colon, MCF-7, and Hs578T breast, and DU 145 prostatic cancer cell proliferation by water-soluble black bean condensed tannins by Bawadi HA, Bansode RR, Trappey A 2nd, Truax RE, Losso JN.(PubMed)
(73) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M, He X, Liu RH. (PubMed)
(74) Inflammation-related signaling pathways implicating TGFβ are revealed in the expression profiling of MCF7 cell treated with fermentedsoybean, chungkookjang by Hwang JS, Yoo HJ, Song HJ, Kim KK, Chun YJ, Matsui T, Kim HB.(PubMed)
(75) A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma by Kinouchi FL, Maia DC, de Abreu Ribeiro LC, Placeres MC, de Valdez GF, Colombo LL, Rossi EA, Carlos IZ. (PubMed)
(76) Peanut agglutinin inhibits proliferation of cultured breast cancer cells by Marth C, Daxenbichler G.(PubMed)
(77) The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro by Valentiner U, Fabian S, Schumacher U, Leathem AJ. (PubMed)
(78) beta-Sitosterol activates Fas signaling in human breast cancer cells by Awad AB, Chinnam M, Fink CS, Bradford PG. (PubMed)
(79) Dietary flaxseed-trastuzumab interactive effects on the growth of HER2-overexpressing human breast tumors (BT-474) by Mason JK, Fu MH, Chen J, Yu Z, Thompson LU. (PubMed)
(80) Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways by Saggar JK, Chen J, Corey P, Thompson LU. (PubMed)
(81)Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk by Lowcock EC, Cotterchio M, Boucher BA. (PubMed)
Broccoli Protein's Hydrolysates Demonstrate a Significant Hypotensive Effect Through ACE inhibitory activity, Researchers Say
Kyle J. Norton
Blood pressure is the force of the blood pushing against the arterial walls. In high blood pressure, the heart has to work harder than normal to pump blood through the circulation system. Over time, high blood pressure has been found to cause damage to the heart and arteries.
Hypertension or high blood pressure is a condition characterized by persistent high blood pressure.
In the US approximately, one-third of adults have high blood pressure, affecting over 77 million people in the country.
Additionally, among adults aged 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.
High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.
High blood pressure is a chronic condition associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
In other words, if you can control your diet, such as making changes to your lifestyle, maintaining an ideal weight, and dieting with low salt, you could do just fine without the drugs.
The cause of high blood pressure is a result of hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.
According to the American Heart Association (AHA), patients with blood pressure that is higher than 130 over 80 millimeters of mercury (mmHg) are considered to have hypertension.
Untreated chronic high blood pressure may induce complications of heart attack, stroke, and other health conditions.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
In finding a potential plant that processes anti-high blood pressure, researchers examined the broccoli protein hydrolysates' inhibitory activity in vitro and hypotensive effect in vivo.
According to the results of the analysis,
* Three ACE inhibitory peptides were isolated and identified as IPPAYTK, LVLPGELAK, and TFQGPPHGIQVER, and their inhibitory IC50 values were 23.5, 184.0, and 3.4 μM, respectively.
* LVLPGE and LAK, two novel peptides exhibited the highest ACE inhibitory activity associated with lowering hypertension with IC50 values of 13.5 and 48.0 μM, respectively.
* Moreover, the hypotensive effect of the peptides was assessed after oral administration to spontaneous hypertensive rats (SHRs).
Collectively, researchers said, "LVLPGE and LAK demonstrated a significant hypotensive effect in vivo. Protein from broccoli may thus constitute a potential antihypertensive peptide source".
Taken together, broccoli may be considered a functional food for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In Vitro and in Vivo Studies on the Angiotensin-Converting Enzyme Inhibitory Activity Peptides Isolated from Broccoli Protein Hydrolysate by Dang Y1, Zhou T2, Hao L1, Cao J1, Sun Y1, Pan D. (PubMed)
Blood pressure is the force of the blood pushing against the arterial walls. In high blood pressure, the heart has to work harder than normal to pump blood through the circulation system. Over time, high blood pressure has been found to cause damage to the heart and arteries.
Hypertension or high blood pressure is a condition characterized by persistent high blood pressure.
In the US approximately, one-third of adults have high blood pressure, affecting over 77 million people in the country.
Additionally, among adults aged 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.
High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.
High blood pressure is a chronic condition associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
In other words, if you can control your diet, such as making changes to your lifestyle, maintaining an ideal weight, and dieting with low salt, you could do just fine without the drugs.
The cause of high blood pressure is a result of hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.
According to the American Heart Association (AHA), patients with blood pressure that is higher than 130 over 80 millimeters of mercury (mmHg) are considered to have hypertension.
Untreated chronic high blood pressure may induce complications of heart attack, stroke, and other health conditions.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
In finding a potential plant that processes anti-high blood pressure, researchers examined the broccoli protein hydrolysates' inhibitory activity in vitro and hypotensive effect in vivo.
According to the results of the analysis,
* Three ACE inhibitory peptides were isolated and identified as IPPAYTK, LVLPGELAK, and TFQGPPHGIQVER, and their inhibitory IC50 values were 23.5, 184.0, and 3.4 μM, respectively.
* LVLPGE and LAK, two novel peptides exhibited the highest ACE inhibitory activity associated with lowering hypertension with IC50 values of 13.5 and 48.0 μM, respectively.
* Moreover, the hypotensive effect of the peptides was assessed after oral administration to spontaneous hypertensive rats (SHRs).
Collectively, researchers said, "LVLPGE and LAK demonstrated a significant hypotensive effect in vivo. Protein from broccoli may thus constitute a potential antihypertensive peptide source".
Taken together, broccoli may be considered a functional food for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In Vitro and in Vivo Studies on the Angiotensin-Converting Enzyme Inhibitory Activity Peptides Isolated from Broccoli Protein Hydrolysate by Dang Y1, Zhou T2, Hao L1, Cao J1, Sun Y1, Pan D. (PubMed)
Tuesday, 11 July 2023
#Herbal #DandelionRootExtract #DRE Potentially Suppresses Proliferation and Migration in #GastricCancer, Researchers Find
Kyle J. Norton
The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.
Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.
Stomach cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man's lifetime is about 1 in 95.
Most patients with stomach cancer in the early stage are asymptomatic.
However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight, loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.
The causes of gastric cancer are debatable, but some researchers suggested that people with chronic
gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease.
Other diseases associated with the early onset of gastric cancer are obesity and smoking.
According to the Universidad de Salamanca, bacteria and viruses, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined the effects of dandelion root extract (DRE) on gastric cancer.
According to the tested assays,
* Dandelion root extract (DRE) specifically and effectively suppresses proliferation and migration in human gastric cells without inducing toxicity in noncancerous cells.
* Long noncoding RNAs (lncRNAs) are known to promote tumorigenesis in many cancer types and are downregulated by the injection of DRE, including the lncRNA colon cancer-associated transcript-1 (CCAT1) in the promotion of tumor progression.
* More importantly, the downregulation of CCAT1 was found to inhibit the proliferation and migration of gastric cells.
Based on the results, researchers suggest, "DRE exerted its function in GC cells partially through targeting CCAT1. This data will provide a basis on which further research in cancer treatment through DRE can be executed".
Taken altogether, Dandelion may be considered an antioxidant remedy for the treatment of gastric cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dandelion root extract suppressed gastric cancer cells proliferation and migration through targeting lncRNA-CCAT1 by Zhu H1, Zhao H2, Zhang L1, Xu J1, Zhu C1, Zhao H1, Lv G. (PubMed)
(2) Stomach cancer by Mayo Clinic
The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.
Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.
Stomach cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man's lifetime is about 1 in 95.
Most patients with stomach cancer in the early stage are asymptomatic.
However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight, loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.
The causes of gastric cancer are debatable, but some researchers suggested that people with chronic
gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease.
Other diseases associated with the early onset of gastric cancer are obesity and smoking.
According to the Universidad de Salamanca, bacteria and viruses, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined the effects of dandelion root extract (DRE) on gastric cancer.
According to the tested assays,
* Dandelion root extract (DRE) specifically and effectively suppresses proliferation and migration in human gastric cells without inducing toxicity in noncancerous cells.
* Long noncoding RNAs (lncRNAs) are known to promote tumorigenesis in many cancer types and are downregulated by the injection of DRE, including the lncRNA colon cancer-associated transcript-1 (CCAT1) in the promotion of tumor progression.
* More importantly, the downregulation of CCAT1 was found to inhibit the proliferation and migration of gastric cells.
Based on the results, researchers suggest, "DRE exerted its function in GC cells partially through targeting CCAT1. This data will provide a basis on which further research in cancer treatment through DRE can be executed".
Taken altogether, Dandelion may be considered an antioxidant remedy for the treatment of gastric cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dandelion root extract suppressed gastric cancer cells proliferation and migration through targeting lncRNA-CCAT1 by Zhu H1, Zhao H2, Zhang L1, Xu J1, Zhu C1, Zhao H1, Lv G. (PubMed)
(2) Stomach cancer by Mayo Clinic
#Tomato Powder (TP) Inhibits Parameters Associated with the Risk of #ColorectalCancer in Vitro and Vivo, Researchers Say
Kyle J. Norton
Colorectal cancer is a medical condition caused by irregular cell growth in the tissues of the colon or rectum.
Most cases of colorectal cancer start in the cell on the surface of the inner lining of the colon or rectum, before penetrating into the deeper layer to induce localized tumors.
At the very early stage of colorectal cancer, most patients are asymptomatic due to the very size of the tumor which does not affect the function of the colon or rectum. However, at the advanced stage, the oversize tumor can press on the nearby blood vessels and nerves and affect the organ's functioning, leading to severe pain and bleeding and specific symptoms accompanied by the general symptoms shared by other types of cancer.
At this stage, cancer cells can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
According to the statistics provided by the American Cancer Society, colorectal cancer is the third most common cancer diagnosed in both men and women in the United States. Proximately, in 2019, 101,420 new cases of colon cancer and 44,180 rectal cancer will be diagnosed.
The lifetime risk of developing colorectal cancer is about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
The 5-year survival rate of people with localized stage colorectal cancer is 90%. However, only 39% of patients are diagnosed at an early stage.
Out of many risk factors associated with the onset of colorectal cancer, some researchers suggested that the widespread of colorectal cancer in South Korea may be correlated with the promotion of a high-fat diet over the past few decades, particularly in men.
Dr. Kim, Jeehyun, wrote, "In men, total fat intake was not associated with risk of colorectal adenoma. However, the risk of colorectal adenoma increased with higher saturated fatty acid (SFA) intake. The adjusted odds ratio in the highest quintile was 1.71 (95% confidence interval, 1.01–2.91) compared with that in the lowest quintile".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a potential compound for the treatment of colon cancer, researchers investigated the effects of tomato powder (TP) on the development of azoxymethane (AOM)-induced colorectal cancer in Wistar rats.
According to the tested assays, TP added to feed at a 5% rate decreased the rate of aberrant crypt foci (ACF) associated with the early stage of colon cancer development and reduces the development of adenocarcinoma and growth of AOM-induced colorectal cancer in rats.
TP supplementation also demonstrated chemopreventive activities against the protein involved in the stimulating production of proinflammatory cytokines in the colon tissues and promoted cancer cell apoptosis.
Based on the findings, Dr. Tuzcu M, the lead scientist wrote, "Our findings identify an intimate connection between dietary supplementation of TP and the decreased risk of colorectal cancer in rats".
And "suggest that consumption of TP would be a natural candidate for the prevention of colorectal cancer in men".
Furthermore, according to the joint study led by the University of Almería, tomatoes showed significant time- and concentration-dependent inhibitory/cytotoxic effects on HT-29 cells.
Moreover, adding tomato carotenoids and olive oil to HT-29 cells in cultures demonstrated a better inhibitory effect compared to the application of individual compounds in CCD-18 normal cells.
In variety comparison, Racimo tomato displayed the most anti-cancer activity against colorectal cancer cell proliferation compared to others, without affecting the normal CCD-18 cells.
In chemical analysis, olive oil and tomato carotenoids inhibited the HT-29 cancer cell proliferation synergistically compared to no effect of other phenolic compounds.
Taken together, tomatoes alone or combined with olive oil may be considered supplements for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-κB and regulating Nrf2/HO-1 pathway by Tuzcu M1, Aslan A, Tuzcu Z, Yabas M, Bahcecioglu IH, Ozercan IH, Kucuk O, Sahin K. (PubMed)
(2) Phytochemical composition and in vitro anti-tumour activities of selected tomatovarieties by Ramos-Bueno RP1, Romero-González R2, González-Fernández MJ1, Guil-Guerrero JL. (PubMed)
(3) Association between dietary fat intake and colorectal adenoma in korean adults
A cross-sectional study by Kim, Jeehyun, MD; Oh, Seung-Won, MD, MBA, PhD; Kim, Young-Sun, MD, PhD; Kwon, Hyuktae, MD, MPH, PhD; Joh, Hee-Kyung, MD, MPH, PhD; Lee, Ji-Eun, MD; Park, Danbee, MD; Park, Jae-Hong, MD; Ko, Ah-Ryoung, MD; Kim, Ye-Ji, MD. (Medicine)
Colorectal cancer is a medical condition caused by irregular cell growth in the tissues of the colon or rectum.
Most cases of colorectal cancer start in the cell on the surface of the inner lining of the colon or rectum, before penetrating into the deeper layer to induce localized tumors.
At the very early stage of colorectal cancer, most patients are asymptomatic due to the very size of the tumor which does not affect the function of the colon or rectum. However, at the advanced stage, the oversize tumor can press on the nearby blood vessels and nerves and affect the organ's functioning, leading to severe pain and bleeding and specific symptoms accompanied by the general symptoms shared by other types of cancer.
At this stage, cancer cells can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
According to the statistics provided by the American Cancer Society, colorectal cancer is the third most common cancer diagnosed in both men and women in the United States. Proximately, in 2019, 101,420 new cases of colon cancer and 44,180 rectal cancer will be diagnosed.
The lifetime risk of developing colorectal cancer is about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
The 5-year survival rate of people with localized stage colorectal cancer is 90%. However, only 39% of patients are diagnosed at an early stage.
Out of many risk factors associated with the onset of colorectal cancer, some researchers suggested that the widespread of colorectal cancer in South Korea may be correlated with the promotion of a high-fat diet over the past few decades, particularly in men.
Dr. Kim, Jeehyun, wrote, "In men, total fat intake was not associated with risk of colorectal adenoma. However, the risk of colorectal adenoma increased with higher saturated fatty acid (SFA) intake. The adjusted odds ratio in the highest quintile was 1.71 (95% confidence interval, 1.01–2.91) compared with that in the lowest quintile".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a potential compound for the treatment of colon cancer, researchers investigated the effects of tomato powder (TP) on the development of azoxymethane (AOM)-induced colorectal cancer in Wistar rats.
According to the tested assays, TP added to feed at a 5% rate decreased the rate of aberrant crypt foci (ACF) associated with the early stage of colon cancer development and reduces the development of adenocarcinoma and growth of AOM-induced colorectal cancer in rats.
TP supplementation also demonstrated chemopreventive activities against the protein involved in the stimulating production of proinflammatory cytokines in the colon tissues and promoted cancer cell apoptosis.
Based on the findings, Dr. Tuzcu M, the lead scientist wrote, "Our findings identify an intimate connection between dietary supplementation of TP and the decreased risk of colorectal cancer in rats".
And "suggest that consumption of TP would be a natural candidate for the prevention of colorectal cancer in men".
Furthermore, according to the joint study led by the University of Almería, tomatoes showed significant time- and concentration-dependent inhibitory/cytotoxic effects on HT-29 cells.
Moreover, adding tomato carotenoids and olive oil to HT-29 cells in cultures demonstrated a better inhibitory effect compared to the application of individual compounds in CCD-18 normal cells.
In variety comparison, Racimo tomato displayed the most anti-cancer activity against colorectal cancer cell proliferation compared to others, without affecting the normal CCD-18 cells.
In chemical analysis, olive oil and tomato carotenoids inhibited the HT-29 cancer cell proliferation synergistically compared to no effect of other phenolic compounds.
Taken together, tomatoes alone or combined with olive oil may be considered supplements for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-κB and regulating Nrf2/HO-1 pathway by Tuzcu M1, Aslan A, Tuzcu Z, Yabas M, Bahcecioglu IH, Ozercan IH, Kucuk O, Sahin K. (PubMed)
(2) Phytochemical composition and in vitro anti-tumour activities of selected tomatovarieties by Ramos-Bueno RP1, Romero-González R2, González-Fernández MJ1, Guil-Guerrero JL. (PubMed)
(3) Association between dietary fat intake and colorectal adenoma in korean adults
A cross-sectional study by Kim, Jeehyun, MD; Oh, Seung-Won, MD, MBA, PhD; Kim, Young-Sun, MD, PhD; Kwon, Hyuktae, MD, MPH, PhD; Joh, Hee-Kyung, MD, MPH, PhD; Lee, Ji-Eun, MD; Park, Danbee, MD; Park, Jae-Hong, MD; Ko, Ah-Ryoung, MD; Kim, Ye-Ji, MD. (Medicine)
#Honey's Treatment Induces Less Discomfort and Itching and Decreased Signs of Eczema in Patients with #ChronicOtitisExterna, Studies Show
Kyle J. Norton
In seeking natural therapy with no side effects, scientists may have found a herbal medicine for the prevention and treatment of acute otitis externa, according to studies.
Acute otitis externa is a condition characterized by the inflammation of the ear canal. Most cases of acute otitis externa are associated with the infection by Pseudomonas aeruginosa and Staphylococcus aureus due to improper cleaning.
However, people with seborrhoeic dermatitis caused by inflammation of greasy areas of the skin can also lead to infection of the ears.
The most common symptoms of acute otitis include itching, canal edema, canal erythema, and otorrhea.
Most cases of acute otitis externa are healed within days with proper ear drops. However, there is a rare case that the disease may take weeks or months to recover.
Chronic otitis externa shares the common symptoms of the acute form, accompanied by water retention and severe ear pain, and temporary loss of hearing, due to building up thick and dry skin can build up inside the ear canal, leading to narrowing the ear canal.
Untreated chronic otitis externa can cause deafness.
Besides sharing the risk factors with the acute form, otitis externa can also be caused by infection due to the long-term use of hearing aids and earplugs.
Unlike the acute form, most cases of otitis externa are treated with steroid drops in addition to antibiotics accompanied by oral intake of pain medications such as ibuprofen.
Generally, oral antibiotics are not recommended, however, if the infection has spread beyond the ear canal, oral antibiotics may be applied.
According to the statistics, otitis externa affects 1–3% of people in America a year, and 95% of people's complaints of the condition are acute.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In finding a natural ingredient for the treatment of eczematous external otitis, scientists investigated the antibacterial potential of medical honey eardrops treatment of eczematous external otitis.
15 patients diagnosed with recurrent eczematous external otitis were selected and treated with medical honey eardrops for 2 weeks.
Honey treatment resulted in less discomfort and itching and decreased signs of eczema with no side effects, according to assays.
Although honey eardrops showed a strong in vitro inhibitory activity against all tested strains, they did not eradicate Staphylococcus aureus infection.
Honey eardrops also reduced the visual analog scale of ear complaints, and a score of eczema, and increased the eradication of bacterial infection. Most patients in the study, are satisfied with the use of honey eardrops for the treatment of their eczematous external otitis.
Dr. Henatsch D, the lead scientist, after taking into account co and confounders said, "The results of this preliminary study indicate a possible role of honey eardrops in eczematous ear disease".
Taken altogether, honey may be considered a functional remedy for the treatment of eczematous external otitis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof-of-Concept Study by Henatsch D1, Nabuurs CH1, van de Goor RM1, Wolffs PF2, Stokroos RJ. (PubMed)
(2) Alternative Treatments for Atopic Dermatitis: An Update by Shi K1, Lio PA. (PubMed)
(2) Acute Otitis Externa: An Update by PAUL SCHAEFER, MD, PhD, and REGINALD F. BAUGH, MD. (AAFP)
In seeking natural therapy with no side effects, scientists may have found a herbal medicine for the prevention and treatment of acute otitis externa, according to studies.
Acute otitis externa is a condition characterized by the inflammation of the ear canal. Most cases of acute otitis externa are associated with the infection by Pseudomonas aeruginosa and Staphylococcus aureus due to improper cleaning.
However, people with seborrhoeic dermatitis caused by inflammation of greasy areas of the skin can also lead to infection of the ears.
The most common symptoms of acute otitis include itching, canal edema, canal erythema, and otorrhea.
Most cases of acute otitis externa are healed within days with proper ear drops. However, there is a rare case that the disease may take weeks or months to recover.
Chronic otitis externa shares the common symptoms of the acute form, accompanied by water retention and severe ear pain, and temporary loss of hearing, due to building up thick and dry skin can build up inside the ear canal, leading to narrowing the ear canal.
Untreated chronic otitis externa can cause deafness.
Besides sharing the risk factors with the acute form, otitis externa can also be caused by infection due to the long-term use of hearing aids and earplugs.
Unlike the acute form, most cases of otitis externa are treated with steroid drops in addition to antibiotics accompanied by oral intake of pain medications such as ibuprofen.
Generally, oral antibiotics are not recommended, however, if the infection has spread beyond the ear canal, oral antibiotics may be applied.
According to the statistics, otitis externa affects 1–3% of people in America a year, and 95% of people's complaints of the condition are acute.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In finding a natural ingredient for the treatment of eczematous external otitis, scientists investigated the antibacterial potential of medical honey eardrops treatment of eczematous external otitis.
15 patients diagnosed with recurrent eczematous external otitis were selected and treated with medical honey eardrops for 2 weeks.
Honey treatment resulted in less discomfort and itching and decreased signs of eczema with no side effects, according to assays.
Although honey eardrops showed a strong in vitro inhibitory activity against all tested strains, they did not eradicate Staphylococcus aureus infection.
Honey eardrops also reduced the visual analog scale of ear complaints, and a score of eczema, and increased the eradication of bacterial infection. Most patients in the study, are satisfied with the use of honey eardrops for the treatment of their eczematous external otitis.
Dr. Henatsch D, the lead scientist, after taking into account co and confounders said, "The results of this preliminary study indicate a possible role of honey eardrops in eczematous ear disease".
Taken altogether, honey may be considered a functional remedy for the treatment of eczematous external otitis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof-of-Concept Study by Henatsch D1, Nabuurs CH1, van de Goor RM1, Wolffs PF2, Stokroos RJ. (PubMed)
(2) Alternative Treatments for Atopic Dermatitis: An Update by Shi K1, Lio PA. (PubMed)
(2) Acute Otitis Externa: An Update by PAUL SCHAEFER, MD, PhD, and REGINALD F. BAUGH, MD. (AAFP)
Subscribe to:
Posts (Atom)