Kyle J. Norton
Vitamin B2 also known as Riboflavin is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc.
The vitamin is essential for normal cellular growth and function.
The vitamin is also best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.
Prostate cancer is a medical condition characterized by prostate cells growing uncontrollably and disorderly.
At the late stage, the prostate cancerous cell can travel a distance away from the prostate to infect other healthy organs and tissue.
Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.
Epidemiological studies, linking vitamin B2 to reduce the risk of prostate cancer have produced inconsistent results.
The Pro
Luckily, in the study of Cancer Research and Product Development Laboratory, Immunol Ltd, active mixture AM: L-arginine, L-histidine, L-methionine, L-phenylalanine, L-tyrosine, L-tryptophan, L-ascorbate, D-biotin, pyridoxine, riboflavin, adenine, L(-)malate), induced apoptosis through the mitochondrial pathway and G1 arrest in PC-3 cells and in PC-3 xenografts(3).
Also, the interaction of interaction between β-cyclodextrin (βCD) or hydroxypropyl-β-cyclodextrin (HPβCD) and riboflavin(RF) indicated that both RF-βCD and RF-HPβCD complexes were cytotoxic to PC3 prostate cancer cells(4).
Other researchers suggested that there is a weak association between prostate cancer incidence and dietary intake of riboflavin and between riboflavin intake and prostate cancer mortality(5).
But in the study of the role of diet in prostate cancer, researchers suggested that intake of linoleic acid and riboflavin (in subjects 50 years and over) could be protective when compared with control subjects(10).
In the study of the effects of irradiated riboflavin on androgen-independent humans, by Universidade Estadual de Campinas, researchers showed that riboflavin photoproducts are cytotoxic to these cells in a FasL-Fas-dependent manner, through inhibited matrix-degrading proteases(involved both the process of ECM remodeling and angiogenesis and in a potential causal relationship between these processes) caused downregulation of VEGF(vascular endothelial growth factor ) and upregulation of TIMP1(inhibitor of metalloproteinases)(9).
The Con
Overexpression of riboflavin carrier protein (RCP) in the prostate cancer patient may be used as a marker in -targeted diagnosis and for the assessment of vascular metabolism in tumors(6).
In localized both androgen-dependent and independent prostate cancer cell lines, antibodies to chicken RCP inhibited the incorporation of tritiated thymidine into DNA and prevented riboflavin uptake in PC3 prostate cancer cells(7).
Another suggestion of elevated plasma concentrations of choline and vitamin B2 may be associated with an increased risk of prostate cancer(8).
In prostate cancer cell line cancer (LnCap), vitamin B2 intakes were not associated with prostate cancer survival(1)
And dietary supplements, including vitamin B2 effective treatments for PC patients, are not supported by sound clinical evidence(2).
Taken together, vitamin B2 may be considered a vital component of any treatment plan instead of the sole means for prevention and treatment in prostate cancer patients.
Overdoses of vitamin B2 may cause symptoms of skin rashes, hypersensitivity, high blood pressure, etc...
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) One-carbon metabolism-related nutrients and prostate cancer survival by Kasperzyk JL, Fall K, Mucci LA, Håkansson N, Wolk A, Johansson JE, Andersson SO, Andrén O(PubMed)
(2) Dietary supplements and prostate cancer: a systematic review of double-blind, placebo-controlled randomized clinical trials by Posadzki P, Lee MS, Onakpoya I, Lee HW, Ko BS, Ernst E.(PubMed)
(3) A mixture of amino acids and other small molecules present in the serum suppresses the growth of murine and human tumors in vivo by Kulcsár G, Gaál D, Kulcsár PI, Schulcz Á, Czömpöly T(PubMed)
(4) Non-inclusion complexes between riboflavin and cyclodextrins by de Jesus MB, Fraceto LF, Martini MF, Pickholz M, Ferreira CV, de Paula E(PubMed)
(5) Dietary intake of B vitamins and methionine and prostate cancer incidence and mortality by Bassett JK, Severi G, Hodge AM, Baglietto L, Hopper JL, English DR, Giles GG. (PubMed)
(6) Riboflavin carrier protein-targeted fluorescent USPIO for the assessment of vascular metabolism in tumors by Jayapaul J, Arns S, Lederle W, Lammers T, Comba P, Gätjens J, Kiessling F(PubMed)
(7) Biochemical characterization of riboflavin carrier protein (RCP) in prostate cancer by Johnson T, Ouhtit A, Gaur R, Fernando A, Schwarzenberger P, Su J, Ismail MF, El-Sayyad HI, Karande A, Elmageed ZA, Rao P, Raj M(PubMed)
(8) One-carbon metabolism and prostate cancer risk: a prospective investigation of seven circulating B vitamins and metabolites by Johansson M, Van Guelpen B, Vollset SE, Hultdin J, Bergh A, Key T, Midttun O, Hallmans G, Ueland PM, Stattin P(PubMed)
(9) A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumors by de Souza Queiroz KC, Zambuzzi WF, Santos de Souza AC, da Silva RA, Machado D, Justo GZ, Carvalho HF, Peppelenbosch MP, Ferreira C(PubMed)
(10) The role of diet in prostate cancer by Kaul L, Heshmat MY, Kovi J, Jackson MA, Jackson AG, Jones GW, Edson M, Enterline JP, Worrell RG, Perry SL(PubMed)
Sunday, 9 July 2023
#HerbalMedicnes Inhibit #Asthma Symptoms and the Onset of Asthma through Their #AntiProinflammatroy Properties, Scientists Say
Kyle J. Norton
Respiratory Disease is a medical condition that affects the breathing organ and tissues including Inflammatory lung diseases, such as obstructive lung diseases, restrictive lung diseases, respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves,....... and muscle breathing.
Asthma is a chronic inflammatory disease, affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
The disease affects people of all ages and mostly starts during childhood.
According to the American Academy, allergy, asthma, and immunology, about 1 in 10 children (10%) had asthma and 1 in 12 adults (8%) had asthma in 2009. (about 25 million, or 8% of the U.S. population)(1).
Asthma symptoms vary from person to person. However, asthma attacks may induce serious symptoms of shortness of breath, chest tightness or pain,...... and cough that causes trouble sleeping
Some researchers suggested that asthma attacks may be a result of allergic effects, such as pollen, mold spores, occupational effects such as gases or dust,..... and physical effects such as exercise.
Epidemiological studies, linking herbs in reduced risk and treatment have been inconclusive(a)(b)(c)(d), but certain herbs have been found to be effective in some studies.
1. Angelica sinensis (Oliv.)
Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine as an antispasmodic and vasodilatory agent, to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc.
In other words, Dang Qui is used frequently to treat gynecological ailments, fatigue, mild anemia, and high blood pressure.
The herb also processes analgesic, anti-inflammatory, etc.
Ethanolic extract (AD of Angelica in the study at the Korea Institute of Oriental Medicine, showed to suppress airway allergic inflammation, by significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E in mice(1).
Danggui Buxue Tang, a composition of Angelica sinensis (AS) and Astragalus membranaceous (AM), in OVA-sensitized mice, its DBT2 or DBT3 showed no improved effects relative to DBT1 in treating asthmatic symptoms but DBT1 showed to suppress airway hyperresponsiveness and OVA-immunoglobulin E (IgE) in serum(2).
According to Thammasat University, ethanol found in Angelica sinensis exerted its anti-inflammatory activity through antioxidant effects(3).
2. Ginkgo biloba
Ginkgo biloba is the oldest living tree species, genus Ginkgo, belongings to the family Ginkgoaceae, native to China, from the temperate zone to the subtropical zone and some parts of North America.
It Has been used in traditional herbal medicine in treating impotence, memory loss, respiratory diseases, circulatory disorders, and deafness as well as to prevent drunkenness and bedwetting.
Ginkgolide B (GKB), a major chemical compound of ginkgo biloba, in BALB/c mice exerted its anti-asthmatic activity through inhibited the increase of T-helper 2 cytokines, such as interleukin (IL)-5 and IL-13 in bronchoalveolar lavage fluid (BALF) and decreased eosinophil count via inhibition of the ERK/MAPK signaling pathway(4).
The composition of Ginkgo biloba leaf extract (EGb761), astaxanthin (ASX), and vitamin C, also inhibited asthma-associated inflammation in asthmatic guinea pigs (5)
And, Ginkgo biloba extracts showed to inhibit asthmatic disorder through the suppression of NF-kappaB gene expression actively in HL-60 cells(6).
According to Dokuz Eylul University Hospital, biloba alleviates all established chronic histological changes in the lung except smooth muscle thickness in a mouse model of asthma(7).
3. Licorice
Licorice (Glycyrrhiza Glabra) also known as sweetwood, is the genus Glycyrrhiza, belonging to the family Fabaceae, native to the Mediterranean and certain areas of Asia.
The herb has been used in traditional medicine to treat skin diseases, coughs, constipation, bronchitis, inflammation, arthritis, etc.
Licochalcone A (Lico A) isolated from the root of Xinjiang licorice, exerted its anti-inflammatory activity on a non-infectious mouse model of asthma, through inhibition of the increase in T-helper type 2 cytokines and reduced serum levels of OVA-specific IgE and IgG(8).
ASHMI, the composition of aqueous extracts of Lingzhi (Ganoderma lucidum), Kushen (Sophora flavescens) and Gancao (Glycyrrhizauralensis), is effective on allergic asthma, through inhibition of the production of interleukin (IL)-4 and IL-5 by murine memory Th2 cells and eotaxin-1 production by HLF-1 cells(9).
Another study in a murine model also suggested that ASHMI not only significantly reduces eosinophilic pulmonary inflammation, serum IgE levels, IL-4 and IL-13 levels, but also increases IFN-γ production in lung cell cultures in response to antigen stimulation(10).
4. Chamomile
Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Water composition extract of a mixture of eight herbs (chamomile, saffron, anise, fennel, caraway, licorice, cardamom, and black seed), showed to alleviate the symptoms of asthma, through inhibition of histamine released from chemically- and immunologically-induced cells(11).
5. Garlic
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.
It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Diallyl disulfide (DADS), a major organosulfur compound found in garlic, in an ovalbumin-induced model of allergic asthma and RAW264.7 cells, showed to inhibit the proinflammatory proteins, through upregulation of Nrf-2/HO-1 and downregulation of NF-κB pathways(12).
According to the study by Tarbiat Modares University, purified aged garlic extract exhibited the protective effect of asthma through a significant decrease in the hallmark criteria of allergic airway inflammation levels(13).
6. Grape seed extract
Grapefruit seed extract (GSE) is a liquid extracted from the seeds, pulp, and white membranes of grapefruit.
The herb has been used in traditional medicine as an anti-bacterial, viral, fungal, parasite and to enhance the immune system, protect against colds and flu, and malignant diseases.
Grape seed extract (GSPE) may alleviate the symptoms of asthma through its antioxidant activities.
According to the study of the University of Ulsan College of Medicine, GSPE effectively suppressed inflammation in both acute and chronic mouse models of asthma, through reduced airway hyperresponsiveness (AHR), decreased inflammatory cells in the BAL fluid, reduced lung inflammation, and decreased IL-4, IL-5, IL-13, and eotaxin-1 expression(14) by downregulating the iNOS expression(15).
Some researchers suggested that GSE significantly ameliorated the pathological changes of ovalbumin-induced asthma, through inhibition of altered lung parenchyma pathology and inflammation in the ovalbumin-induced murine asthma model(16).
Most important, even though the application of some herbs mentioned above exerted an enormous effect in the inhibition of asthma symptoms and asthma but most of the data on the health effects are based on human cells and animal models.
Therefore, further data collection on studies performed with human consumption over a long term and during the course of the disease will be necessary to complete the picture of the possibilities of the above herbal efficacy.
Additionally, while addressing the possible advantages of herbal intake researchers must also take into account potential, risks such as quality controls, dosages, and dosage-induced adverse effects of acute liver toxicity.
Where interleukin (IL)-4, IL-5, 13, and tumor necrosis factor (TNF)-alpha are pro-inflammatory cytokines activated by an immune response against infection caused by microorganisms.
Eotaxin-1 expression is activated by IL-13 or TNF-α with the function of directing inflammatory cells through its receptors.
Nrf2/HO-1 is a protein with the function to react as the anti-oxidative stress response.
Nitric oxide synthase (iNOS), a major mediator of inflammation, plays an important role in response to stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1 by Lee MY1, Seo CS, Lee JA, Lee NH, Kim JH, Ha H, Zheng MS, Son JK, Shin HK. (PubMed)
(2) Danggui Buxue Tang attenuates eosinophil infiltration and airway hyperresponsiveness in asthmatic mice by Lin CC1, Liou CJ, Chiang CY, Huang WY, Huang WC. (PubMed)
(3) Antioxidant and nitric oxide inhibition activities of Thai medicinal plants by Makchuchit S1, Itharat A, Tewtrakul S.(PubMed)
(4) A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway by Chu X1, Ci X, He J, Wei M, Yang X, Cao Q, Li H, Guan S, Deng Y, Pang D, Deng X.(PubMed)
(5) Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen by Haines DD1, Varga B, Bak I, Juhasz B, Mahmoud FF, Kalantari H, Gesztelyi R, Lekli I, Czompa A, Tosaki A(PubMed)
(6) [Studies on the effect of Ginkgo biloba extracts on NF-kappaB pathway].[Article in Chinese] by Li GH1, Lei XX, Yi YM, Xu BL, Wang HP, Du J.(PubMed)
(7) Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma by Babayigit A1, Olmez D, Karaman O, Ozogul C, Yilmaz O, Kivcak B, Erbil G, Uzuner N.(PubMed)
(8) Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A by Chu X1, Jiang L, Wei M, Yang X, Guan M, Xie X, Wei J, Liu D, Wang D.(PubMed)
(9) Constituents of the anti-asthma herbal formula ASHMI(TM) synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro by Jayaprakasam B1, Yang N, Wen MC, Wang R, Goldfarb J, Sampson H, Li XM. (PubMed)
(10) Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo by Yang N1, Patil S, Zhuge J, Wen MC, Bolleddula J, Doddaga S, Goldfarb J, Sampson HA, Li XM.(PubMed)
(11) The effect of a herbal water extract on histamine release from mast cells and on allergic asthma by Haggag EG1, Abou-Moustafa MA, Boucher W, Theoharides TC. (PubMed)
(12) Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression by Shin IS1, Hong J, Jeon CM, Shin NR, Kwon OK, Kim HS, Kim JC, Oh SR, Ahn KS. (PubMed)
(13) Purified aged garlic extract modulates allergic airway inflammation in BALB/c mice by Zare A1, Farzaneh P, Pourpak Z, Zahedi F, Moin M, Shahabi S, Hassan ZM. (PubMed)
(14) Grape seed proanthocyanidin extract attenuates allergic inflammation in murine models of asthma by Lee T1, Kwon HS, Bang BR, Lee YS, Park MY, Moon KA, Kim TB, Lee KY, Moon HB, Cho YS. (PubMed)
(15) Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase by Zhou DY1, Du Q, Li RR, Huang M, Zhang Q, Wei GZ. (PubMed)
(16) Grape seed extract attenuates lung parenchyma pathology in ovalbumin-induced mouse asthma model: an ultrastructural study by Mahmoud YI. (PubMed)
Respiratory Disease is a medical condition that affects the breathing organ and tissues including Inflammatory lung diseases, such as obstructive lung diseases, restrictive lung diseases, respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves,....... and muscle breathing.
Asthma is a chronic inflammatory disease, affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
The disease affects people of all ages and mostly starts during childhood.
According to the American Academy, allergy, asthma, and immunology, about 1 in 10 children (10%) had asthma and 1 in 12 adults (8%) had asthma in 2009. (about 25 million, or 8% of the U.S. population)(1).
Asthma symptoms vary from person to person. However, asthma attacks may induce serious symptoms of shortness of breath, chest tightness or pain,...... and cough that causes trouble sleeping
Some researchers suggested that asthma attacks may be a result of allergic effects, such as pollen, mold spores, occupational effects such as gases or dust,..... and physical effects such as exercise.
Epidemiological studies, linking herbs in reduced risk and treatment have been inconclusive(a)(b)(c)(d), but certain herbs have been found to be effective in some studies.
1. Angelica sinensis (Oliv.)
Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine as an antispasmodic and vasodilatory agent, to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc.
In other words, Dang Qui is used frequently to treat gynecological ailments, fatigue, mild anemia, and high blood pressure.
The herb also processes analgesic, anti-inflammatory, etc.
Ethanolic extract (AD of Angelica in the study at the Korea Institute of Oriental Medicine, showed to suppress airway allergic inflammation, by significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E in mice(1).
Danggui Buxue Tang, a composition of Angelica sinensis (AS) and Astragalus membranaceous (AM), in OVA-sensitized mice, its DBT2 or DBT3 showed no improved effects relative to DBT1 in treating asthmatic symptoms but DBT1 showed to suppress airway hyperresponsiveness and OVA-immunoglobulin E (IgE) in serum(2).
According to Thammasat University, ethanol found in Angelica sinensis exerted its anti-inflammatory activity through antioxidant effects(3).
2. Ginkgo biloba
Ginkgo biloba is the oldest living tree species, genus Ginkgo, belongings to the family Ginkgoaceae, native to China, from the temperate zone to the subtropical zone and some parts of North America.
It Has been used in traditional herbal medicine in treating impotence, memory loss, respiratory diseases, circulatory disorders, and deafness as well as to prevent drunkenness and bedwetting.
Ginkgolide B (GKB), a major chemical compound of ginkgo biloba, in BALB/c mice exerted its anti-asthmatic activity through inhibited the increase of T-helper 2 cytokines, such as interleukin (IL)-5 and IL-13 in bronchoalveolar lavage fluid (BALF) and decreased eosinophil count via inhibition of the ERK/MAPK signaling pathway(4).
The composition of Ginkgo biloba leaf extract (EGb761), astaxanthin (ASX), and vitamin C, also inhibited asthma-associated inflammation in asthmatic guinea pigs (5)
And, Ginkgo biloba extracts showed to inhibit asthmatic disorder through the suppression of NF-kappaB gene expression actively in HL-60 cells(6).
According to Dokuz Eylul University Hospital, biloba alleviates all established chronic histological changes in the lung except smooth muscle thickness in a mouse model of asthma(7).
3. Licorice
Licorice (Glycyrrhiza Glabra) also known as sweetwood, is the genus Glycyrrhiza, belonging to the family Fabaceae, native to the Mediterranean and certain areas of Asia.
The herb has been used in traditional medicine to treat skin diseases, coughs, constipation, bronchitis, inflammation, arthritis, etc.
Licochalcone A (Lico A) isolated from the root of Xinjiang licorice, exerted its anti-inflammatory activity on a non-infectious mouse model of asthma, through inhibition of the increase in T-helper type 2 cytokines and reduced serum levels of OVA-specific IgE and IgG(8).
ASHMI, the composition of aqueous extracts of Lingzhi (Ganoderma lucidum), Kushen (Sophora flavescens) and Gancao (Glycyrrhizauralensis), is effective on allergic asthma, through inhibition of the production of interleukin (IL)-4 and IL-5 by murine memory Th2 cells and eotaxin-1 production by HLF-1 cells(9).
Another study in a murine model also suggested that ASHMI not only significantly reduces eosinophilic pulmonary inflammation, serum IgE levels, IL-4 and IL-13 levels, but also increases IFN-γ production in lung cell cultures in response to antigen stimulation(10).
4. Chamomile
Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Water composition extract of a mixture of eight herbs (chamomile, saffron, anise, fennel, caraway, licorice, cardamom, and black seed), showed to alleviate the symptoms of asthma, through inhibition of histamine released from chemically- and immunologically-induced cells(11).
5. Garlic
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.
It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Diallyl disulfide (DADS), a major organosulfur compound found in garlic, in an ovalbumin-induced model of allergic asthma and RAW264.7 cells, showed to inhibit the proinflammatory proteins, through upregulation of Nrf-2/HO-1 and downregulation of NF-κB pathways(12).
According to the study by Tarbiat Modares University, purified aged garlic extract exhibited the protective effect of asthma through a significant decrease in the hallmark criteria of allergic airway inflammation levels(13).
6. Grape seed extract
Grapefruit seed extract (GSE) is a liquid extracted from the seeds, pulp, and white membranes of grapefruit.
The herb has been used in traditional medicine as an anti-bacterial, viral, fungal, parasite and to enhance the immune system, protect against colds and flu, and malignant diseases.
Grape seed extract (GSPE) may alleviate the symptoms of asthma through its antioxidant activities.
According to the study of the University of Ulsan College of Medicine, GSPE effectively suppressed inflammation in both acute and chronic mouse models of asthma, through reduced airway hyperresponsiveness (AHR), decreased inflammatory cells in the BAL fluid, reduced lung inflammation, and decreased IL-4, IL-5, IL-13, and eotaxin-1 expression(14) by downregulating the iNOS expression(15).
Some researchers suggested that GSE significantly ameliorated the pathological changes of ovalbumin-induced asthma, through inhibition of altered lung parenchyma pathology and inflammation in the ovalbumin-induced murine asthma model(16).
Most important, even though the application of some herbs mentioned above exerted an enormous effect in the inhibition of asthma symptoms and asthma but most of the data on the health effects are based on human cells and animal models.
Therefore, further data collection on studies performed with human consumption over a long term and during the course of the disease will be necessary to complete the picture of the possibilities of the above herbal efficacy.
Additionally, while addressing the possible advantages of herbal intake researchers must also take into account potential, risks such as quality controls, dosages, and dosage-induced adverse effects of acute liver toxicity.
Where interleukin (IL)-4, IL-5, 13, and tumor necrosis factor (TNF)-alpha are pro-inflammatory cytokines activated by an immune response against infection caused by microorganisms.
Eotaxin-1 expression is activated by IL-13 or TNF-α with the function of directing inflammatory cells through its receptors.
Nrf2/HO-1 is a protein with the function to react as the anti-oxidative stress response.
Nitric oxide synthase (iNOS), a major mediator of inflammation, plays an important role in response to stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1 by Lee MY1, Seo CS, Lee JA, Lee NH, Kim JH, Ha H, Zheng MS, Son JK, Shin HK. (PubMed)
(2) Danggui Buxue Tang attenuates eosinophil infiltration and airway hyperresponsiveness in asthmatic mice by Lin CC1, Liou CJ, Chiang CY, Huang WY, Huang WC. (PubMed)
(3) Antioxidant and nitric oxide inhibition activities of Thai medicinal plants by Makchuchit S1, Itharat A, Tewtrakul S.(PubMed)
(4) A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway by Chu X1, Ci X, He J, Wei M, Yang X, Cao Q, Li H, Guan S, Deng Y, Pang D, Deng X.(PubMed)
(5) Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen by Haines DD1, Varga B, Bak I, Juhasz B, Mahmoud FF, Kalantari H, Gesztelyi R, Lekli I, Czompa A, Tosaki A(PubMed)
(6) [Studies on the effect of Ginkgo biloba extracts on NF-kappaB pathway].[Article in Chinese] by Li GH1, Lei XX, Yi YM, Xu BL, Wang HP, Du J.(PubMed)
(7) Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma by Babayigit A1, Olmez D, Karaman O, Ozogul C, Yilmaz O, Kivcak B, Erbil G, Uzuner N.(PubMed)
(8) Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A by Chu X1, Jiang L, Wei M, Yang X, Guan M, Xie X, Wei J, Liu D, Wang D.(PubMed)
(9) Constituents of the anti-asthma herbal formula ASHMI(TM) synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro by Jayaprakasam B1, Yang N, Wen MC, Wang R, Goldfarb J, Sampson H, Li XM. (PubMed)
(10) Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo by Yang N1, Patil S, Zhuge J, Wen MC, Bolleddula J, Doddaga S, Goldfarb J, Sampson HA, Li XM.(PubMed)
(11) The effect of a herbal water extract on histamine release from mast cells and on allergic asthma by Haggag EG1, Abou-Moustafa MA, Boucher W, Theoharides TC. (PubMed)
(12) Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression by Shin IS1, Hong J, Jeon CM, Shin NR, Kwon OK, Kim HS, Kim JC, Oh SR, Ahn KS. (PubMed)
(13) Purified aged garlic extract modulates allergic airway inflammation in BALB/c mice by Zare A1, Farzaneh P, Pourpak Z, Zahedi F, Moin M, Shahabi S, Hassan ZM. (PubMed)
(14) Grape seed proanthocyanidin extract attenuates allergic inflammation in murine models of asthma by Lee T1, Kwon HS, Bang BR, Lee YS, Park MY, Moon KA, Kim TB, Lee KY, Moon HB, Cho YS. (PubMed)
(15) Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase by Zhou DY1, Du Q, Li RR, Huang M, Zhang Q, Wei GZ. (PubMed)
(16) Grape seed extract attenuates lung parenchyma pathology in ovalbumin-induced mouse asthma model: an ultrastructural study by Mahmoud YI. (PubMed)
#Cinnamon Inhibits Parameters in #Diabetes, According to Studies
Kyle J. Norton
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Type 1 diabetes is a congenital condition caused by the die-off of pancreas cells which are responsible for producing insulin, a hormone with a function to control the level of blood glucose.
A regular injection of insulin or insulin therapy is required daily in a patient who was born with the disease.
In contrast to type II diabetes, type 1 diabetes is not associated with dietary intake or unhealthy lifestyle that can cause an increase in glucose levels in the blood.
According to Diabetes Canada, patients with type 1 diabetes should be aware of the number of insulin injections that are needed per day; the timing of insulin injections, and the dose of insulin that is needed with each injection
The cause of type 1 diabetes is debatable, but some researchers found that most patients with type 1 diabetes are linked to an abnormal body’s immune system overreaction to the cells that make insulin.
On the other hand, type 2 diabetes is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol due to unhealthy dietary and lifestyle selections.
In some cases, the disease is also caused by allergic reactions of cells in the immune system.
If you experience some of the physical symptoms of frequent urination, excessive thirst, unexplained weight loss, nonrefractive visual impairment, and appetite problems, together with gastrointestinal symptoms such as stomach pain, heartburn, diarrhea, constipation, nausea, and vomiting, and mental symptoms of depression, emotional stress, sleeping difficulties,..... and suicidal ideation, you may have type 2 diabetes. Please check with your doctor as soon as possible(4).
According to the 2011 statistic from National Diabetes Information Clearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, have diabetes in 2010.
About 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010.
And approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
From my years of practice and research, I do believe that intake of 1/4 tablespoon of Vietnamese cinnamon powder in the morning and evening has significant effects in keeping blood sugar in check.
In prediabetes with the morning reading of 6.9 mmol/L of a lady whom I know for 10 years, intake of the volume of cinnamon suggested above has managed to maintain her morning blood glucose at 5.3 mmol/L since.
Cinnamon, a kitchen spice used in many cultures, may have gained many believers, including medical professionals because of its antidiabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects.
According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce blood sugar significantly with little or no adverse side effects.
The herb has been used in herbal and traditional medicine as anti-fungal and bacteria activities and improves reproductive organs prevents flatulence and intestinal cramping, treats indigestion, diarrhea, bad breath, headache, migraine, etc.(1).
In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, researchers found that oral administration of cinnamon reduced significantly blood triglyceride levels even in the low-dose group, after 3 months. (2).
Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering insulin secretion may be attributed to its effects in lowering triglyceride and increasing liver glycogen content and improving insulin action in liver tissues(3).
Dr. Kim SH and Dr. Choung SY. told PubMed that “the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism”(4).
Peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARγ, and PPARβ/δ are receptors that reduce triglyceride level and regulate energy homeostasis.
In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomum cassia) displayed a significant improvement of glucose, insulin, cholesterol, and HbA1c in patients with type 2 diabetes, according to a double-blind placebo-controlled study(7).
Unfortunately, according to the Western University of Health Sciences, even though consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but a high degree of heterogeneity including quality and content may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5).
Moreover, a randomized clinical trial in which 70 Patients with type II diabetes were assigned randomly into two groups (35 in cinnamon and 35 in the placebo group) for the testing of the effect of cinnamon on the glucose level in the blood, at the end of the experiment researchers found that there is an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).
Taken altogether, although there are some discrepancies involving cinnamon efficacy, I do believe that cinnamon in low doses is effective to control and manage the level of blood glucose in a patient with diabetes without altering the insulin level.
However, according to Dr. Georgakopoulou EA(7), oral intake of cinnamon may cause Stomatitis, and a burning sensation in the mouth if it is taken in large amounts.
Traditional Chinese medicine also indicated that overdoses of cinnamon can be toxic and damage the liver(1).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Type 1 diabetes is a congenital condition caused by the die-off of pancreas cells which are responsible for producing insulin, a hormone with a function to control the level of blood glucose.
A regular injection of insulin or insulin therapy is required daily in a patient who was born with the disease.
In contrast to type II diabetes, type 1 diabetes is not associated with dietary intake or unhealthy lifestyle that can cause an increase in glucose levels in the blood.
According to Diabetes Canada, patients with type 1 diabetes should be aware of the number of insulin injections that are needed per day; the timing of insulin injections, and the dose of insulin that is needed with each injection
The cause of type 1 diabetes is debatable, but some researchers found that most patients with type 1 diabetes are linked to an abnormal body’s immune system overreaction to the cells that make insulin.
On the other hand, type 2 diabetes is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol due to unhealthy dietary and lifestyle selections.
In some cases, the disease is also caused by allergic reactions of cells in the immune system.
If you experience some of the physical symptoms of frequent urination, excessive thirst, unexplained weight loss, nonrefractive visual impairment, and appetite problems, together with gastrointestinal symptoms such as stomach pain, heartburn, diarrhea, constipation, nausea, and vomiting, and mental symptoms of depression, emotional stress, sleeping difficulties,..... and suicidal ideation, you may have type 2 diabetes. Please check with your doctor as soon as possible(4).
According to the 2011 statistic from National Diabetes Information Clearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, have diabetes in 2010.
About 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010.
And approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
From my years of practice and research, I do believe that intake of 1/4 tablespoon of Vietnamese cinnamon powder in the morning and evening has significant effects in keeping blood sugar in check.
In prediabetes with the morning reading of 6.9 mmol/L of a lady whom I know for 10 years, intake of the volume of cinnamon suggested above has managed to maintain her morning blood glucose at 5.3 mmol/L since.
Cinnamon, a kitchen spice used in many cultures, may have gained many believers, including medical professionals because of its antidiabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects.
According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce blood sugar significantly with little or no adverse side effects.
The herb has been used in herbal and traditional medicine as anti-fungal and bacteria activities and improves reproductive organs prevents flatulence and intestinal cramping, treats indigestion, diarrhea, bad breath, headache, migraine, etc.(1).
In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, researchers found that oral administration of cinnamon reduced significantly blood triglyceride levels even in the low-dose group, after 3 months. (2).
Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering insulin secretion may be attributed to its effects in lowering triglyceride and increasing liver glycogen content and improving insulin action in liver tissues(3).
Dr. Kim SH and Dr. Choung SY. told PubMed that “the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism”(4).
Peroxisome proliferator-activated receptors (PPARs) including PPARα, PPARγ, and PPARβ/δ are receptors that reduce triglyceride level and regulate energy homeostasis.
In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomum cassia) displayed a significant improvement of glucose, insulin, cholesterol, and HbA1c in patients with type 2 diabetes, according to a double-blind placebo-controlled study(7).
Unfortunately, according to the Western University of Health Sciences, even though consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but a high degree of heterogeneity including quality and content may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5).
Moreover, a randomized clinical trial in which 70 Patients with type II diabetes were assigned randomly into two groups (35 in cinnamon and 35 in the placebo group) for the testing of the effect of cinnamon on the glucose level in the blood, at the end of the experiment researchers found that there is an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).
Taken altogether, although there are some discrepancies involving cinnamon efficacy, I do believe that cinnamon in low doses is effective to control and manage the level of blood glucose in a patient with diabetes without altering the insulin level.
However, according to Dr. Georgakopoulou EA(7), oral intake of cinnamon may cause Stomatitis, and a burning sensation in the mouth if it is taken in large amounts.
Traditional Chinese medicine also indicated that overdoses of cinnamon can be toxic and damage the liver(1).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY. (PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(8) Diabetes – The Symptoms by Kyle J. Norton
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(8) Diabetes – The Symptoms by Kyle J. Norton
#Tocopherols and #Carotenoids are Associated with a Lower Risk of #CervicalCancer, Researchers Say
Kyle J. Norton
The cervix is the lower part of the uterus that opens at the top of the vagina.
The cervix acts as a transition area for the vaginal lining (squamous epithelium) and uterus (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with alternation of cell DNA.
Precervical cancer is the early stage of abnormal cell changes in the cervical tissue.
If left untreated, it can develop into true invasive cervical cancer caused by factors connected to male seminal fluid. A vaccine, Gardasil used to prevent pre-cervical cancer from the infection of two types of HPV was approved by the U.S. Food and Drug Administration in 2006. It is for your benefit to take this vaccine if you are sexually active with several partners.
Types of invasive cervical cancer
* Squamous cell carcinomas
Squamous cells are the thin, flat cells that line the bottom of the cervix.
Abnormal growth of squamous cells accounted for 80 to 90% of invasive cervical cancer. Squamous cell carcinomas are defined as cancer in which the squamous cells in the cervix have divided and replication in uncontrolled matter due to DNA alternation caused by a virus or other factors.
* Adenocarcinoma
Glandular cells that line the upper portion of the cervix. Abnormal growth of glandular epithelial cells is accounted for 10 to 20 percent of invasive cervical cancers. Adenocarcinoma is defined as cancer of which the glandular epithelium cells in the cervix have divided and replication in uncontrolled matter due to DNA alternation caused by a virus or other factors.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
In finding a potential phytochemical for the treatment of chronic diseases, researchers examined the relationship between serum carotenoid, retinol, and tocopherol concentrations and the risk of cervical cancer among Chinese women.
According to the analysis of the hospital-based case-control study in which 358 adults (158 incident cases and 200 controls) were recruited from Xinjiang, China,
* There was an inverse association between serum carotenoid (α-carotene, β-carotene, and lutein/zeaxanthin) and tocopherol (α-tocopherol) concentrations and the risk of cervical cancer after adjusting for potential confounders compared to no effects of the levels of retinol.
* ORs for 1-SD increase were 0.71 (95% CI: 0.56- 0.92; p=0.003) for total carotenoids and 0.75 (95% CI: 0.60-0.94; p=0.008) for total tocopherols.
After taking other factors into account, researchers said, "These results show that higher serum concentrations of some carotenoids and tocopherols are associated with a lower risk of cervical cancer among Chinese women".
Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of cervical cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women by Zhang YY1, Lu L, Abliz G, Mijit F. (PubMed)
The cervix is the lower part of the uterus that opens at the top of the vagina.
The cervix acts as a transition area for the vaginal lining (squamous epithelium) and uterus (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with alternation of cell DNA.
Precervical cancer is the early stage of abnormal cell changes in the cervical tissue.
If left untreated, it can develop into true invasive cervical cancer caused by factors connected to male seminal fluid. A vaccine, Gardasil used to prevent pre-cervical cancer from the infection of two types of HPV was approved by the U.S. Food and Drug Administration in 2006. It is for your benefit to take this vaccine if you are sexually active with several partners.
Types of invasive cervical cancer
* Squamous cell carcinomas
Squamous cells are the thin, flat cells that line the bottom of the cervix.
Abnormal growth of squamous cells accounted for 80 to 90% of invasive cervical cancer. Squamous cell carcinomas are defined as cancer in which the squamous cells in the cervix have divided and replication in uncontrolled matter due to DNA alternation caused by a virus or other factors.
* Adenocarcinoma
Glandular cells that line the upper portion of the cervix. Abnormal growth of glandular epithelial cells is accounted for 10 to 20 percent of invasive cervical cancers. Adenocarcinoma is defined as cancer of which the glandular epithelium cells in the cervix have divided and replication in uncontrolled matter due to DNA alternation caused by a virus or other factors.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
In finding a potential phytochemical for the treatment of chronic diseases, researchers examined the relationship between serum carotenoid, retinol, and tocopherol concentrations and the risk of cervical cancer among Chinese women.
According to the analysis of the hospital-based case-control study in which 358 adults (158 incident cases and 200 controls) were recruited from Xinjiang, China,
* There was an inverse association between serum carotenoid (α-carotene, β-carotene, and lutein/zeaxanthin) and tocopherol (α-tocopherol) concentrations and the risk of cervical cancer after adjusting for potential confounders compared to no effects of the levels of retinol.
* ORs for 1-SD increase were 0.71 (95% CI: 0.56- 0.92; p=0.003) for total carotenoids and 0.75 (95% CI: 0.60-0.94; p=0.008) for total tocopherols.
After taking other factors into account, researchers said, "These results show that higher serum concentrations of some carotenoids and tocopherols are associated with a lower risk of cervical cancer among Chinese women".
Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of cervical cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women by Zhang YY1, Lu L, Abliz G, Mijit F. (PubMed)
#Omega-3 Fatty Acids Promote Brain Neuron Activity and Enhanced White Matter Integrity After Ischemic Stroke, According to Studies
Kyle J. Norton
Cardiovascular diseases refer to heart diseases and stroke, affecting millions of people in the world. According to statistics, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors of the diseases.
In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagic, due to bleeding.
A stroke is a medical emergency. Early intervention is most cases can minimize brain damage and potential complications.
Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.
Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.
There is a general belief that stroke is an accumulation over a long period of an unhealthy diet with red meat and processed meats in the induction of artery-clogging.
Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow, and decreased the chance of blood clots.
Sadly, stroke is one of the most common causes of death worldwide.
In the US, according to statistics, approximately 800,000 people suffer a stroke of which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.
According to the statistics, in the US, stroke is the leading cause of serious, long-term disability.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of mega-3 polyunsaturated fatty acids (n-3 PUFAs) in alleviating ischemic brain injury in young adult rodents.
The study included aged (18-month-old) mice which were administered n-3 PUFA-enriched fish oil in daily chow for 3 months before and up to 8 weeks after 45 minutes of transient middle cerebral artery occlusion (tMCAO).
According to the results of differentiation,
* Mice receiving dietary supplementation of n-3 PUFAs for 3 months showed significant increases in brain ratio of n-3/n-6 PUFA contents.
* Furthermore, the administration of dietary supplementation of n-3 PUFAs for 3 months also markedly reduced long-term sensorimotor deficits and chronic ischemic brain tissue loss after tMCAO.
* Moreover, n-3 PUFAs robustly promoted post-ischemic angiogenesis and neurogenesis to enhance the brain neuron activity and enhanced white matter integrity after tMCAO.
* Most importantly, the enhancement of neurogenesis and white matter integrity were both correlated positively with the improvement of sensorimotor activities after tMCAO.
Collectively, researchers said, "prophylactic dietary supplementation of n-3 PUFAs effectively improves long-term stroke outcomes in aged mice, perhaps by promoting post-stroke brain repair processes such as angiogenesis, neurogenesis, and white matter restoration".
Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the improvement of long-term stroke outcomes, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids by Cai M1, Zhang W1, Weng Z2, Stetler RA1,2,3, Jiang X2, Shi Y2,3, Gao Y1,2, Chen J. (PubMed)
(2) Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts by Saber H1, Yakoob MY1, Shi P1, Longstreth WT Jr1, Lemaitre RN1, Siscovick D1, Rexrode KM1, Willett WC1, Mozaffarian D. (PubMed)
Cardiovascular diseases refer to heart diseases and stroke, affecting millions of people in the world. According to statistics, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors of the diseases.
In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagic, due to bleeding.
A stroke is a medical emergency. Early intervention is most cases can minimize brain damage and potential complications.
Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.
Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.
There is a general belief that stroke is an accumulation over a long period of an unhealthy diet with red meat and processed meats in the induction of artery-clogging.
Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow, and decreased the chance of blood clots.
Sadly, stroke is one of the most common causes of death worldwide.
In the US, according to statistics, approximately 800,000 people suffer a stroke of which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.
According to the statistics, in the US, stroke is the leading cause of serious, long-term disability.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of mega-3 polyunsaturated fatty acids (n-3 PUFAs) in alleviating ischemic brain injury in young adult rodents.
The study included aged (18-month-old) mice which were administered n-3 PUFA-enriched fish oil in daily chow for 3 months before and up to 8 weeks after 45 minutes of transient middle cerebral artery occlusion (tMCAO).
According to the results of differentiation,
* Mice receiving dietary supplementation of n-3 PUFAs for 3 months showed significant increases in brain ratio of n-3/n-6 PUFA contents.
* Furthermore, the administration of dietary supplementation of n-3 PUFAs for 3 months also markedly reduced long-term sensorimotor deficits and chronic ischemic brain tissue loss after tMCAO.
* Moreover, n-3 PUFAs robustly promoted post-ischemic angiogenesis and neurogenesis to enhance the brain neuron activity and enhanced white matter integrity after tMCAO.
* Most importantly, the enhancement of neurogenesis and white matter integrity were both correlated positively with the improvement of sensorimotor activities after tMCAO.
Collectively, researchers said, "prophylactic dietary supplementation of n-3 PUFAs effectively improves long-term stroke outcomes in aged mice, perhaps by promoting post-stroke brain repair processes such as angiogenesis, neurogenesis, and white matter restoration".
Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the improvement of long-term stroke outcomes, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids by Cai M1, Zhang W1, Weng Z2, Stetler RA1,2,3, Jiang X2, Shi Y2,3, Gao Y1,2, Chen J. (PubMed)
(2) Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts by Saber H1, Yakoob MY1, Shi P1, Longstreth WT Jr1, Lemaitre RN1, Siscovick D1, Rexrode KM1, Willett WC1, Mozaffarian D. (PubMed)
#BetaSitosterol Inhibits #ProinflammatroyCytokines Associated with Chronic Inflammatory Diseases in Obese, According to Studies
Kyle J. Norton
Inflammation is a natural response of the immune system in the stimulation of the production of inflammatory cytokines with an aim to protect our body against infectious agents in the acute phase of bodily injury and tissue damage.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
However, in many instances, overexpression of pro-inflammatory cytokines can cause cell death and tissue damage, leading to irreversible organ damage with large scar formation.
For example, overexpression of pro-inflammatory cytokines in the healing of hepatitis virus infection can lead to liver scars.
Furthermore, inflammation that lasts more than 3 months may be considered chronic inflammation, a leading cause of chronic diseases.
Chronic inflammation occurs when the immune system no longer has the ability to kill off all the infectious agents, during the onset of acute infection.
Moreover, chronic inflammation also happens in people with autoimmune disorders. In this case, the immune system attacks the bodily normal healthy tissue, by mistaking them for foreign pathogens that cause disease.
Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Obesity is associated with a chronic inflammatory response, associated with abnormal production, and pro-inflammatory cytokines are observed by several biological markers.
Conditions associated with obesity-related chronic inflammation are cardiovascular diseases and metabolic syndromes, insulin resistance, type 2 diabetes, and hepatic steatosis,
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
In finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers elucidated the physiological roles of phytosterols in both clinical studies and animal experiments on obesity-related chronic inflammation.
According to the chemical analysis, serum sitosterol level showed a negative correlation with the expression of pro-inflammatory cytokines (IL-6 and the TNF-α) in both diabetic subjects (n=46) and non-diabetic subjects (n=178).
According to the Multiple regression analyses, ABCG5/8 hetero mice with elevated plasma sitosterol levels without any modulation of food intake fed a high-fat diet, inhibited the increase in body weight, fatty liver changes, and the expansion of perigonadal adipose tissues, compared to high fat diet-fed only ABCG5/8 hetero mice.
Furthermore, parameters associated with obese related inflammation such as the plasma IL-6 and TNF-α levels, the expressions of TNF-α and PAI-1 in the liver, and the expressions of the IL-6, TNF-α, and MCP-1 levels in the adipose tissue were lower in ABCG5/8 KO mice were lower in the ABCG5/8 hetero mice with elevated plasma sitosterol.
Based on the findings, researchers said, "These results suggest that sitosterol might suppress obesity-related chronic inflammation and might be applicable to the treatment of metabolic diseases".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of obesity-related chronic inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sitosterol prevents obesity-related chronic inflammation by Kurano M1, Hasegawa K2, Kunimi M2, Hara M3, Yatomi Y1, Teramoto T4, Tsukamoto K. (Europe PMC)
Inflammation is a natural response of the immune system in the stimulation of the production of inflammatory cytokines with an aim to protect our body against infectious agents in the acute phase of bodily injury and tissue damage.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
However, in many instances, overexpression of pro-inflammatory cytokines can cause cell death and tissue damage, leading to irreversible organ damage with large scar formation.
For example, overexpression of pro-inflammatory cytokines in the healing of hepatitis virus infection can lead to liver scars.
Furthermore, inflammation that lasts more than 3 months may be considered chronic inflammation, a leading cause of chronic diseases.
Chronic inflammation occurs when the immune system no longer has the ability to kill off all the infectious agents, during the onset of acute infection.
Moreover, chronic inflammation also happens in people with autoimmune disorders. In this case, the immune system attacks the bodily normal healthy tissue, by mistaking them for foreign pathogens that cause disease.
Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Obesity is associated with a chronic inflammatory response, associated with abnormal production, and pro-inflammatory cytokines are observed by several biological markers.
Conditions associated with obesity-related chronic inflammation are cardiovascular diseases and metabolic syndromes, insulin resistance, type 2 diabetes, and hepatic steatosis,
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
In finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers elucidated the physiological roles of phytosterols in both clinical studies and animal experiments on obesity-related chronic inflammation.
According to the chemical analysis, serum sitosterol level showed a negative correlation with the expression of pro-inflammatory cytokines (IL-6 and the TNF-α) in both diabetic subjects (n=46) and non-diabetic subjects (n=178).
According to the Multiple regression analyses, ABCG5/8 hetero mice with elevated plasma sitosterol levels without any modulation of food intake fed a high-fat diet, inhibited the increase in body weight, fatty liver changes, and the expansion of perigonadal adipose tissues, compared to high fat diet-fed only ABCG5/8 hetero mice.
Furthermore, parameters associated with obese related inflammation such as the plasma IL-6 and TNF-α levels, the expressions of TNF-α and PAI-1 in the liver, and the expressions of the IL-6, TNF-α, and MCP-1 levels in the adipose tissue were lower in ABCG5/8 KO mice were lower in the ABCG5/8 hetero mice with elevated plasma sitosterol.
Based on the findings, researchers said, "These results suggest that sitosterol might suppress obesity-related chronic inflammation and might be applicable to the treatment of metabolic diseases".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of obesity-related chronic inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sitosterol prevents obesity-related chronic inflammation by Kurano M1, Hasegawa K2, Kunimi M2, Hara M3, Yatomi Y1, Teramoto T4, Tsukamoto K. (Europe PMC)
#Antioxidant #Lycopene inhibits the #HighBloodCholesterol Against the Onset #Atherosclerosis in Vivo, Researchers Say
Kyle J. Norton
Atherosclerosis is a condition caused by long-term plaques built up on the wall of the arteries. Over time, continued plaque accumulation can lead to cardiovascular disease.
In other words, narrowing the arteries due to plaque accumulation is a major cause of heart disease and stroke.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.
Epidemiologically, the most common risk factors of atherosclerosis are unhealthy blood cholesterol levels associated with high levels of bad and low levels of good cholesterol, high blood pressure, smoking, insulin resistance, diabetes, overweight or obesity, and physical inactivity.
The most common symptoms found in patients with antiatherosclerosis are involved in the reduced blood flow to the body including, chest pain or angina, pain in the leg, and arm, shortness of breath, and fatigue and confusion.
Some researchers suggested that the promotion of a high-fat diet that induces widespread obesity in the Western world may be one of the major culprits that cause atherosclerosis.
Dr. Lovren F and colleagues wrote, "Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases".
And, " A plethora of mechanisms, including abnormalities in lipid metabolism, insulin resistance, inflammation, endothelial dysfunction, adipokine imbalance, and inflammasome activation have been suggested to underlie the relationship between obesity and atherosclerosis.".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potent compound for the protection of arterial functions, researchers investigated the effects of lycopene on the diet-induced increase in serum lipid levels and the initiation of atherosclerosis in an animal model.
New Zealand White (NZW) rabbits. enrolled in the study were divided into four groups of 9 animals each, fed either a standard diet, a high-cholesterol diet containing 0.5% cholesterol, a high-cholesterol diet containing placebo beadlets, or a high-cholesterol diet plus 5 mg/kg body weight/day of lycopene (in the form of lycopene beadlets), for 4 weeks.
According to the chemical analysis of phytochemicals, the animal group treated with lycopene beadlets showed significantly elevated lycopene plasma levels compared to other groups.
The lycopene group demonstrated a significant reduction of 50% in total cholesterol and LDL cholesterol serum levels compared to the high-cholesterol and placebo groups.
Levels of cholesteryl ester accumulated in the aorta were significantly decreased in the lycopene-treated group without a significant decrease in the extent of aortic surface lipid accumulation.
In other words, lycopene inhibited some parameters associated with the increased risk of atherosclerosis, particularly in cholesterol levels.
Based on the findings, researchers concluded, "Lycopene supplementation for 4 weeks increased lycopene plasma levels in the animals. Although we found strongly reduced total and LDL cholesterol serum levels as well as significantly lower amounts of cholesteryl ester in the aortae in the lycopene-treated group".
Moreover, in the comparison of the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene in the animal model, lycopene exerted an anti-atherosclerotic property in high cholesterol diet-fed rats by decreasing TC, LDL-C, VLDL-C, and triglycerides and increased HDL-C level significantly compared to the control.
Lycopene used a combination with Astaxanthin also showed better hypolipidemic and anti-atherogenic potential compared to the individual application.
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of atherosclerosis pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Antioxidant, Hypolipidemic, and Antiatherogenic Property of Lycopene and Astaxanthin in Atherosclerosis-induced Rats by Kumar R1, Salwe KJ2, Kumarappan M. (PubMed)
(2) Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits by Lorenz M1, Fechner M, Kalkowski J, Fröhlich K, Trautmann A, Böhm V, Liebisch G, Lehneis S, Schmitz G, Ludwig A, Baumann G, Stangl K, Stangl V. (PubMed)
Atherosclerosis is a condition caused by long-term plaques built up on the wall of the arteries. Over time, continued plaque accumulation can lead to cardiovascular disease.
In other words, narrowing the arteries due to plaque accumulation is a major cause of heart disease and stroke.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.
Epidemiologically, the most common risk factors of atherosclerosis are unhealthy blood cholesterol levels associated with high levels of bad and low levels of good cholesterol, high blood pressure, smoking, insulin resistance, diabetes, overweight or obesity, and physical inactivity.
The most common symptoms found in patients with antiatherosclerosis are involved in the reduced blood flow to the body including, chest pain or angina, pain in the leg, and arm, shortness of breath, and fatigue and confusion.
Some researchers suggested that the promotion of a high-fat diet that induces widespread obesity in the Western world may be one of the major culprits that cause atherosclerosis.
Dr. Lovren F and colleagues wrote, "Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases".
And, " A plethora of mechanisms, including abnormalities in lipid metabolism, insulin resistance, inflammation, endothelial dysfunction, adipokine imbalance, and inflammasome activation have been suggested to underlie the relationship between obesity and atherosclerosis.".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potent compound for the protection of arterial functions, researchers investigated the effects of lycopene on the diet-induced increase in serum lipid levels and the initiation of atherosclerosis in an animal model.
New Zealand White (NZW) rabbits. enrolled in the study were divided into four groups of 9 animals each, fed either a standard diet, a high-cholesterol diet containing 0.5% cholesterol, a high-cholesterol diet containing placebo beadlets, or a high-cholesterol diet plus 5 mg/kg body weight/day of lycopene (in the form of lycopene beadlets), for 4 weeks.
According to the chemical analysis of phytochemicals, the animal group treated with lycopene beadlets showed significantly elevated lycopene plasma levels compared to other groups.
The lycopene group demonstrated a significant reduction of 50% in total cholesterol and LDL cholesterol serum levels compared to the high-cholesterol and placebo groups.
Levels of cholesteryl ester accumulated in the aorta were significantly decreased in the lycopene-treated group without a significant decrease in the extent of aortic surface lipid accumulation.
In other words, lycopene inhibited some parameters associated with the increased risk of atherosclerosis, particularly in cholesterol levels.
Based on the findings, researchers concluded, "Lycopene supplementation for 4 weeks increased lycopene plasma levels in the animals. Although we found strongly reduced total and LDL cholesterol serum levels as well as significantly lower amounts of cholesteryl ester in the aortae in the lycopene-treated group".
Moreover, in the comparison of the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene in the animal model, lycopene exerted an anti-atherosclerotic property in high cholesterol diet-fed rats by decreasing TC, LDL-C, VLDL-C, and triglycerides and increased HDL-C level significantly compared to the control.
Lycopene used a combination with Astaxanthin also showed better hypolipidemic and anti-atherogenic potential compared to the individual application.
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of atherosclerosis pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Antioxidant, Hypolipidemic, and Antiatherogenic Property of Lycopene and Astaxanthin in Atherosclerosis-induced Rats by Kumar R1, Salwe KJ2, Kumarappan M. (PubMed)
(2) Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits by Lorenz M1, Fechner M, Kalkowski J, Fröhlich K, Trautmann A, Böhm V, Liebisch G, Lehneis S, Schmitz G, Ludwig A, Baumann G, Stangl K, Stangl V. (PubMed)
Subscribe to:
Posts (Atom)