Kyle J. Norton
The CETP inhibitor is a class of drugs that inhibit cholesteryl ester transfer protein (CETP) associated with the risk of atherosclerosis (a cardiovascular disease) by improving blood lipid levels in the arteries.
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.
The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaque build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease, and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.
Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.
In finding a potential phytochemical for the treatment of diseases associated with high blood lipids,
researchers examined the cholesteryl ester transfer protein (CETP) for the prevention and treatment of cardiovascular diseases.
According to the analysis of the activity of a series of ursolic acid 3β-ester derivatives CETP inhibiting activities.* The most active compound is U12 with an IC50 value of 2.4 μM.
* More precisely, the possible hydrogen bond interactions between the carboxyl groups at both ends of the molecule skeleton and several polar residues (such as Ser191, Cys13, and Ser230) in the active site region of CETP could significantly enhance the inhibition activity.
After talking about other factors into account, researchers said, "This study provides structural insight of the interactions between these pentacyclic triterpenoid 3β-ester derivatives".
Taken altogether, ursolic acid may be considered a CETP inhibitor for the inhibition of high blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors by Chen C1, Sun R2, Sun Y3, Chen X3, Li F3, Wen X4, Yuan H5, Chen D. (PubMed).
Sunday, 9 July 2023
#Tocopherol Compete with Amino Acids and Proteins for Retinoid Cation Radicals Associated with the Onset of Age-Related Macular Degeneration in Elderly
Kyle J. Norton
Age-related diseases are medical conditions associated with the increase in age. Most recently age-related diseases in the elderly are cardiovascular diseases and macular degeneration.
Cardiovascular diseases are a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.
Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.
In other words, AMD may cause significant visual disability.
Most cases of the early stage of AMD were diagnosed during routine eye health examinations.
The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.
Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increased in size.
Advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to epidemiological studies.
According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.
Besides aging, some researchers suggest that other factors such as smoking, family history, gender, race, sun exposure, diet, and obesity also increase the risk of AMD developing.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of degenerative diseases, researchers examined the effect of β-, γ-, and δ-tocopherols scavenging free radical and cation radicals of another form of vitamin A-retinal against the onset of age-related macular degeneration.
According to the analysis, β-, γ-, and δ-tocopherols showed a significant in scavenging of cation radicals of retinal, followed by retinoic acid, (0.03 to 5.6) × 109 M-1·s-1, and retinol, (0.08 to 1.6) × 108 M-1·s-1.
Trolox is substantially less efficient at scavenging retinoid cation radicals than α-tocopherol and urate, but it is more efficient at scavenging the cation radicals of retinoic acid and retinol than δ-tocopherol.
These scavenging activities suggest that tocopherols can effectively compete with amino acids and proteins for retinoid cation radicals, thereby protecting these important biomolecules from oxidation.
Based on the results, researchers said, "tocopherols can diminish the oxidative damage to the skin and retina and thereby protect from skin photosensitivity and the development and/or progression of changes in blinding retinal diseases such as Stargardt's disease and age-related macular degeneration (AMD)".
Taken altogether, tocopherols may be considered a supplement for reducing the risk of age-related macular degeneration, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Scavenging of Retinoid Cation Radicals by Urate, Trolox, and α-, β-, γ-, and δ-Tocopherols by Rozanowska M1,2, Edge R3, Land EJ4, Navaratnam S5, Sarna T6, Truscott TG. (PubMed)
Age-related diseases are medical conditions associated with the increase in age. Most recently age-related diseases in the elderly are cardiovascular diseases and macular degeneration.
Cardiovascular diseases are a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.
Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.
In other words, AMD may cause significant visual disability.
Most cases of the early stage of AMD were diagnosed during routine eye health examinations.
The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.
Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increased in size.
Advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to epidemiological studies.
According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.
Besides aging, some researchers suggest that other factors such as smoking, family history, gender, race, sun exposure, diet, and obesity also increase the risk of AMD developing.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of degenerative diseases, researchers examined the effect of β-, γ-, and δ-tocopherols scavenging free radical and cation radicals of another form of vitamin A-retinal against the onset of age-related macular degeneration.
According to the analysis, β-, γ-, and δ-tocopherols showed a significant in scavenging of cation radicals of retinal, followed by retinoic acid, (0.03 to 5.6) × 109 M-1·s-1, and retinol, (0.08 to 1.6) × 108 M-1·s-1.
Trolox is substantially less efficient at scavenging retinoid cation radicals than α-tocopherol and urate, but it is more efficient at scavenging the cation radicals of retinoic acid and retinol than δ-tocopherol.
These scavenging activities suggest that tocopherols can effectively compete with amino acids and proteins for retinoid cation radicals, thereby protecting these important biomolecules from oxidation.
Based on the results, researchers said, "tocopherols can diminish the oxidative damage to the skin and retina and thereby protect from skin photosensitivity and the development and/or progression of changes in blinding retinal diseases such as Stargardt's disease and age-related macular degeneration (AMD)".
Taken altogether, tocopherols may be considered a supplement for reducing the risk of age-related macular degeneration, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Scavenging of Retinoid Cation Radicals by Urate, Trolox, and α-, β-, γ-, and δ-Tocopherols by Rozanowska M1,2, Edge R3, Land EJ4, Navaratnam S5, Sarna T6, Truscott TG. (PubMed)
3,3'-#Diindolylmethane Inhibits the #Genes and #Pathways That Cause the Risk of #ProstateCancer, According to Researchers
Kyle J. Norton
Scientists may have found a plan-based bioactive compound for the treatment of prostate cancer with no side effects, according to studies.
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.
The disease often is discovered during the rectum examination annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, frequent and urged urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistics, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, an unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cells by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information of DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer-protective food bioactive, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending the confirmation of a larger sample size and multicenter human study.
Intake of DIM in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous vegetable-derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
Scientists may have found a plan-based bioactive compound for the treatment of prostate cancer with no side effects, according to studies.
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.
The disease often is discovered during the rectum examination annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, frequent and urged urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistics, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, an unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cells by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information of DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer-protective food bioactive, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending the confirmation of a larger sample size and multicenter human study.
Intake of DIM in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous vegetable-derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
#Phytochemical #Alliin Protects thye Heart Functioning by Inhibiting #Isoproterenol ISO Damage to the Heart Physically in MyocardialInfarction in Vivos, Researchers Say
Kyle J. Norton
Myocardial infarction (MI) is a medical condition known as a heart attack caused by the blood flow decreasing or stopping to a part of the heart, leading to damage to the heart muscle.
In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to reduced blood flow to the heart.
According to the statistics provided by the CDC, every year, approximately, about 790,000 Americans have a heart attack, including 580,000 cases of a first heart attack and 210,000 people who have already had a first heart attack.
The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath, and dizziness.
Conventionally, treatment of myocardial infarction is focused to reduce the damage of the heart muscle accomplished through medical or mechanical means.
Dr. James TN in the examination of the complex causes of fatal myocardial infarction wrote, "It is too often deduced that myocardial infarction is due to coronary occlusion and that subsequent death needs no other explanation. But the great majority of myocardial infarctions are not fatal, whether treated or untreated".
And, "There is, of course, some relation to the size of the infarct and the presence or absence of complicating conditions such as diabetes mellitus or hypertension".
In other words, Myocardial infarction can be fatal if the incidence occurs in patients with other medical conditions associated with the risk of cardiovascular diseases, such as metabolic syndrome and diabetes.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In finding a natural compound for the treatment of myocardial infarction, researchers examined the antihyperlipidemic, antilipoperoxidative, and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats.
The study included rats-induced myocardial infarction by subcutaneous injection of isoproterenol (ISO) (150 mg kg(-1)) at an interval of 24 h for 2 days.
Before treatment of SACS, ISO-treated rats showed a significant increase in the levels of serum iron, uric acid, and blood glucose, Na(+) and Ca(2+) associated with electrical abnormalities in the heart.
ISO-treated rats showed a significant decrease in the levels of plasma iron-binding capacity, an indication of inflammation, serum total protein, and albumin/globulin ratio similar to those of patients with abnormal heart rhythm, heart K(+) and heart glycogen involved in weak heart muscles.
In other words, ISO has caused significant damage to the heart functioning physically in myocardial infarction rats.
Furthermore, ISO also induced significant production of proinflammatory cytokines observed by the significant increase in red blood cells, hemoglobin, packed cell volume, white blood cells, neutrophils, platelet count, and fibrinogen level.
Additionally, the heart failure marker of glycoproteins in serum and the heart were increased in both levels/concentrations.
However, oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for 35 days reversed all the biochemical parameters studied in ISO-induced rats.
Collectively, SACS showed a protective effect against ISO-induced myocardial infarction in tested rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of myocardial infarction with no side effects, responding to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes by Saray Quintero-Fabián,1,2 Daniel Ortuño-Sahagún,1 Manuel Vázquez-Carrera,3 and Rocío Ivette López-Roa. (Hindawi)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol-induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) Complex causes of fatal myocardial infarction by James TN. (PubMed
Myocardial infarction (MI) is a medical condition known as a heart attack caused by the blood flow decreasing or stopping to a part of the heart, leading to damage to the heart muscle.
In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to reduced blood flow to the heart.
According to the statistics provided by the CDC, every year, approximately, about 790,000 Americans have a heart attack, including 580,000 cases of a first heart attack and 210,000 people who have already had a first heart attack.
The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath, and dizziness.
Conventionally, treatment of myocardial infarction is focused to reduce the damage of the heart muscle accomplished through medical or mechanical means.
Dr. James TN in the examination of the complex causes of fatal myocardial infarction wrote, "It is too often deduced that myocardial infarction is due to coronary occlusion and that subsequent death needs no other explanation. But the great majority of myocardial infarctions are not fatal, whether treated or untreated".
And, "There is, of course, some relation to the size of the infarct and the presence or absence of complicating conditions such as diabetes mellitus or hypertension".
In other words, Myocardial infarction can be fatal if the incidence occurs in patients with other medical conditions associated with the risk of cardiovascular diseases, such as metabolic syndrome and diabetes.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In finding a natural compound for the treatment of myocardial infarction, researchers examined the antihyperlipidemic, antilipoperoxidative, and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats.
The study included rats-induced myocardial infarction by subcutaneous injection of isoproterenol (ISO) (150 mg kg(-1)) at an interval of 24 h for 2 days.
Before treatment of SACS, ISO-treated rats showed a significant increase in the levels of serum iron, uric acid, and blood glucose, Na(+) and Ca(2+) associated with electrical abnormalities in the heart.
ISO-treated rats showed a significant decrease in the levels of plasma iron-binding capacity, an indication of inflammation, serum total protein, and albumin/globulin ratio similar to those of patients with abnormal heart rhythm, heart K(+) and heart glycogen involved in weak heart muscles.
In other words, ISO has caused significant damage to the heart functioning physically in myocardial infarction rats.
Furthermore, ISO also induced significant production of proinflammatory cytokines observed by the significant increase in red blood cells, hemoglobin, packed cell volume, white blood cells, neutrophils, platelet count, and fibrinogen level.
Additionally, the heart failure marker of glycoproteins in serum and the heart were increased in both levels/concentrations.
However, oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for 35 days reversed all the biochemical parameters studied in ISO-induced rats.
Collectively, SACS showed a protective effect against ISO-induced myocardial infarction in tested rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of myocardial infarction with no side effects, responding to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes by Saray Quintero-Fabián,1,2 Daniel Ortuño-Sahagún,1 Manuel Vázquez-Carrera,3 and Rocío Ivette López-Roa. (Hindawi)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol-induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) Complex causes of fatal myocardial infarction by James TN. (PubMed
Saturday, 8 July 2023
The Over Growth of #CandidaAlbicans Serious #Complications, According to Studies
Kyle J. Norton
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Complications Caused By Over Growth of Candida Albicans
When Candida growth is uncontrolled and becomes fungus, its metabolites and/or toxins(117)(118) interfere with the functioning of nutrient-uptake(107)(108) and penetrate into the bloodstream, causing
1. Neuro effects
Candida produces toxins(acetaldehyde and ethanol)(112)(113) in large quantities that affect our brain and interfere with our biochemical processes, leading to upset levels of hormones and many key chemicals(109), resulting in symptoms of fatigue, aggression, depression, and toxicity and schizophrenia(110)(111).
2. Permeability
As the innermost membrane of the four coats of the intestinal wall becomes permeable due to fungus(114)(115), partially digested foods, toxins produced by fungus and chemical molecules can enter the bloodstream and reach organs that suppress their normal functions, causing immune dysfunction(116)(117) in a long run and many kinds of chronic illness(118)(119).
3. Reproductive dysfunction
Overgrowth of candida can cause reproductive tract infection(120). For the female, it leads to infections of the upper reproductive tract (fallopian tubes, ovary, and uterus)(123), and/or the lower reproductive tract(124) (vagina, cervix, and vulva)(121)(122). For the male, it is at the penis(127), testicles, urethra(128), or sperm tube(125), causing reproductive dysfunction, including infertility(126).
4. Premenstrual syndrome
As overgrowth candida binding to hormones(130), it alters the pathways and their shapes by preventing them from entering the target receptor sites, which makes certain hormones inactive, leading to estrogen and progesterone-affected cell growth, morphology, and virulence(131), in regulating blood sugar(132) and endocrine disruptor causes of premenstrual syndrome(129).
5. Autoimmune disorders
5.1. After entering the bloodstream, it causes allergies reaction in the immune system(133)(134), but some of the antigens' molecules are similar to molecules of human tissue(135), resulting in the immune system attacking both the antigens and the body's healthy tissues, leading to autoimmune disorders(136).
5. 2. The main target of candida target
The main target of candida is to evade the body's immune system for their forever survival in the host body by targeting the immune system response in fighting against invading organism(137) as they change the receptors of foreign organism or theirs' form which is displaying(138), making them difficult for the body's immune cells to react appropriately(19)(140).
5.3. Digestive track colonization
The main purpose of Candida is trying to invade the intestinal wall by suppressing the immune system response (142) with inflammation(141), leading to prolong inflammation, (the prolonged inflammation is called ulceration colitis if it occurs in the large intestine(143)(144) and called Crohn's disease if it occurs in the small intestine(145)(146)(147)) that can cause digestive tract colonization of the host body.
5.4. The mind and emotion
If Candida overgrowth, it produces toxins (ethanol) to affect our brain in released metabolites that interfere with our biochemical processes in hormone production(109), leading to fatigue, aggression, depression, and toxicity(110)(111).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(107) Oral candidiasis and nutritional deficiencies in elderly hospitalised patients. Paillaud E1, Merlier I, Dupeyron C, Scherman E, Poupon J, Bories PN. (PubMed)
(108) Nutritional factors and oral candidosis. Samaranayake LP (PubMed)
(109) Relative risk of vaginal candidiasis after use of antibiotics compared with antidepressants in women: postmarketing surveillance data in England. Wilton L1, Kollarova M, Heeley E, Shakir S.(PubMed)
(110) Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study.Xu J1, Schwartz K, Bartoces M, Monsur J, Severson RK, Sobel JD. (PubMed)
(111) Quantifying effect of combined oral contraceptive pill on functional ovarian reserve as measured by serum anti-Müllerian hormone and small antral follicle count using three-dimensional ultrasound. Deb S1, Campbell BK, Pincott-Allen C, Clewes JS, Cumberbatch G, Raine-Fenning NJ.(PubMed)
(112)[Oral contraception and carbohydrate metabolism--the physiopathological explanation].[Article in French], Hilal M.(PubMed)
(113) PPARγ ligands switched high-fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination. Lefèvre L1, Galès A, Olagnier D, Bernad J, Perez L, Burcelin R, Valentin A, Auwerx J, Pipy B, Coste A.(PubMed)
(114) The epidemiology of vaginal colonization with group B streptococci in a sexually transmitted disease clinic.Honig E1, Mouton JW, van der Meijden WI. (PubMed)
(115)Risk factors for Salmonella infection. Loss of gastric acid linked to candidiasis. Larner AJ.(PubMed)
(116)Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy. Brzozowski T1, Zwolinska-Wcislo M, Konturek PC, Kwiecien S, Drozdowicz D, Konturek SJ, Stachura J, Budak A, Bogdal J, Pawlik WW, Hahn EG.(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI. (PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM. (PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(110) Mercury Poisoning, Candida Yeast, Or Is It Both?
(111) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction. RABY K.(PubMed)(112)Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(113 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(114) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus, and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y.(PubMed)
(115)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(116) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI. (PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM. (PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(120) Mercury Poisoning, Candida Yeast, Or Is It Both?
(121) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction. RABY K.(PubMed)
(122) Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(123 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(124) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus, and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y. (PubMed)
(125)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(126) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(127 )Immunogenetics of type 1 diabetes mellitus. Morran MP1, Vonberg A1, Khadra A2, Pietropaolo M3.(PubMed)
(128) Burden of Fungal Disease - Ireland. Dorgan E1, Denning DW2, McMullan R3.(PubMed)
(129) Burden of serious fungal infections in Spain.
Rodriguez-Tudela JL1, Alastruey-Izquierdo A2, Gago S3, Cuenca-Estrella M2, León C4, Miro JM5, Nuñez Boluda A6, Ruiz Camps I7, Sole A8, Denning DW9; University of Manchester in association with the LIFE program at. Electronic address: http://www.LIFE-worldwide.org.(PubMed)
(130) Prevalence study of genital tract infections in pregnant women referred to health centers in Iran.Mobasheri M, Saeedi Varnamkhast N, Karimi A, Banaeiyan S.(PubMed)
(131)Vaginal infections among pregnant women at Omdurman Maternity Hospital in Khartoum, Sudan Abdelaziz ZA1, Ibrahim ME, Bilal NE, Hamid ME. (PubMed)
(132) Reproductive tract infections among married women in Upper Egypt. Sullam SA1, Mahfouz AA, Dabbous NI, el-Barrawy M, el-Said MM. (PubMed)
(133) Characterization of low molecular weight antimicrobial peptide from human female reproductive tract. Sharma S1, Sethi S, Prasad R, Samanta P, Rajwanshi A, Malhotra S, Sharma M.(PubMed)
(134) Lower genital tract infections in infertile Nigerian women compared with controls.Okonofua FE1, Ako-Nai KA, Dighitoghi MD. (PubMed)
(135) ion of oocyte fertilization by assisted reproductive techniques and increased sperm DNA fragmentation in the presence of Candida albicans: a case report. Burrello N1, Calogero AE, Perdichizzi A, Salmeri M, D'Agata R, Vicari E.(PubMed)
(136) Studies on the significance of positive bacterial semen cultures in male fertility in Nigeria.Onemu SO1, Ibeh IN. (PubMed)
(137) Mycetomatoid infection of the penis by Candida albicans. Mastrolorenzo A1, Giomi B, Cipollini EM, Tammaro R, Decarli N, Cammelli D, Fabiani Tropeano F, Tiradritti L, Difonzo EM, Zuccati G.(PubMed)
(138) Candida albicans epididymo-orchitis and fungemia in a patient with chronic myelogenous leukemia Mark Pimentel, MD, Lindsay E Nicolle, MD FRCPC, and Salman Qureshi, MD FRCPC(PubMed)
(139) Normocalcemic tetany and candidiasis. Galland L.(PubMed)
(140) Interaction of Candida albicans with genital mucosa: effect of sex hormones on adherence of yeasts in vitro. Kalo A1, Segal E.(PubMed)
(141) Response of pathogenic and non-pathogenic yeasts to steroids. Prasad R1, Devaux F, Dhamgaye S, Banerjee D.(PubMed)
(142)Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An in vivo Study. Ganapathy DM1, Joseph S, Ariga P, Selvaraj A.(PubMed)
(143)Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Cenci E1, Romani L, Vecchiarelli A, Puccetti P, Bistoni F.(PubMed)
(144)[Squamous epithelial carcinoma in a 27-year-old patient with cellular immune defect].[Article in German] Kübler A1, Ziegler C, Barth T, Zöller J.(PubMed)
(145)Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines. Rinaldi M1, Perricone C, Ortega-Hernandez OD, Perricone R, Shoenfeld Y. (PubMed)
(146)Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006-2007 and 2012-2013.Kamikawa Y1, Mori Y, Nagayama T, Fujisaki J, Hirabayashi D, Sakamoto R, Hamada T, Sugihara K.(PubMed)
(147)Oxidative and nitrosative stress on phagocytes' function: from effective defense to immune evasion mechanisms. Ferrari CK1, Souto PC, França EL, Honorio-França AC. (PubMed)
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Complications Caused By Over Growth of Candida Albicans
When Candida growth is uncontrolled and becomes fungus, its metabolites and/or toxins(117)(118) interfere with the functioning of nutrient-uptake(107)(108) and penetrate into the bloodstream, causing
1. Neuro effects
Candida produces toxins(acetaldehyde and ethanol)(112)(113) in large quantities that affect our brain and interfere with our biochemical processes, leading to upset levels of hormones and many key chemicals(109), resulting in symptoms of fatigue, aggression, depression, and toxicity and schizophrenia(110)(111).
2. Permeability
As the innermost membrane of the four coats of the intestinal wall becomes permeable due to fungus(114)(115), partially digested foods, toxins produced by fungus and chemical molecules can enter the bloodstream and reach organs that suppress their normal functions, causing immune dysfunction(116)(117) in a long run and many kinds of chronic illness(118)(119).
3. Reproductive dysfunction
Overgrowth of candida can cause reproductive tract infection(120). For the female, it leads to infections of the upper reproductive tract (fallopian tubes, ovary, and uterus)(123), and/or the lower reproductive tract(124) (vagina, cervix, and vulva)(121)(122). For the male, it is at the penis(127), testicles, urethra(128), or sperm tube(125), causing reproductive dysfunction, including infertility(126).
4. Premenstrual syndrome
As overgrowth candida binding to hormones(130), it alters the pathways and their shapes by preventing them from entering the target receptor sites, which makes certain hormones inactive, leading to estrogen and progesterone-affected cell growth, morphology, and virulence(131), in regulating blood sugar(132) and endocrine disruptor causes of premenstrual syndrome(129).
5. Autoimmune disorders
5.1. After entering the bloodstream, it causes allergies reaction in the immune system(133)(134), but some of the antigens' molecules are similar to molecules of human tissue(135), resulting in the immune system attacking both the antigens and the body's healthy tissues, leading to autoimmune disorders(136).
5. 2. The main target of candida target
The main target of candida is to evade the body's immune system for their forever survival in the host body by targeting the immune system response in fighting against invading organism(137) as they change the receptors of foreign organism or theirs' form which is displaying(138), making them difficult for the body's immune cells to react appropriately(19)(140).
5.3. Digestive track colonization
The main purpose of Candida is trying to invade the intestinal wall by suppressing the immune system response (142) with inflammation(141), leading to prolong inflammation, (the prolonged inflammation is called ulceration colitis if it occurs in the large intestine(143)(144) and called Crohn's disease if it occurs in the small intestine(145)(146)(147)) that can cause digestive tract colonization of the host body.
5.4. The mind and emotion
If Candida overgrowth, it produces toxins (ethanol) to affect our brain in released metabolites that interfere with our biochemical processes in hormone production(109), leading to fatigue, aggression, depression, and toxicity(110)(111).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(107) Oral candidiasis and nutritional deficiencies in elderly hospitalised patients. Paillaud E1, Merlier I, Dupeyron C, Scherman E, Poupon J, Bories PN. (PubMed)
(108) Nutritional factors and oral candidosis. Samaranayake LP (PubMed)
(109) Relative risk of vaginal candidiasis after use of antibiotics compared with antidepressants in women: postmarketing surveillance data in England. Wilton L1, Kollarova M, Heeley E, Shakir S.(PubMed)
(110) Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study.Xu J1, Schwartz K, Bartoces M, Monsur J, Severson RK, Sobel JD. (PubMed)
(111) Quantifying effect of combined oral contraceptive pill on functional ovarian reserve as measured by serum anti-Müllerian hormone and small antral follicle count using three-dimensional ultrasound. Deb S1, Campbell BK, Pincott-Allen C, Clewes JS, Cumberbatch G, Raine-Fenning NJ.(PubMed)
(112)[Oral contraception and carbohydrate metabolism--the physiopathological explanation].[Article in French], Hilal M.(PubMed)
(113) PPARγ ligands switched high-fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination. Lefèvre L1, Galès A, Olagnier D, Bernad J, Perez L, Burcelin R, Valentin A, Auwerx J, Pipy B, Coste A.(PubMed)
(114) The epidemiology of vaginal colonization with group B streptococci in a sexually transmitted disease clinic.Honig E1, Mouton JW, van der Meijden WI. (PubMed)
(115)Risk factors for Salmonella infection. Loss of gastric acid linked to candidiasis. Larner AJ.(PubMed)
(116)Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy. Brzozowski T1, Zwolinska-Wcislo M, Konturek PC, Kwiecien S, Drozdowicz D, Konturek SJ, Stachura J, Budak A, Bogdal J, Pawlik WW, Hahn EG.(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI. (PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM. (PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(110) Mercury Poisoning, Candida Yeast, Or Is It Both?
(111) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction. RABY K.(PubMed)(112)Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(113 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(114) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus, and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y.(PubMed)
(115)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(116) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis of metabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI. (PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM. (PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(120) Mercury Poisoning, Candida Yeast, Or Is It Both?
(121) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction. RABY K.(PubMed)
(122) Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(123 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(124) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus, and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y. (PubMed)
(125)A new look at the antibiotic amphotericin B effect on Candidaalbicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(126) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(127 )Immunogenetics of type 1 diabetes mellitus. Morran MP1, Vonberg A1, Khadra A2, Pietropaolo M3.(PubMed)
(128) Burden of Fungal Disease - Ireland. Dorgan E1, Denning DW2, McMullan R3.(PubMed)
(129) Burden of serious fungal infections in Spain.
Rodriguez-Tudela JL1, Alastruey-Izquierdo A2, Gago S3, Cuenca-Estrella M2, León C4, Miro JM5, Nuñez Boluda A6, Ruiz Camps I7, Sole A8, Denning DW9; University of Manchester in association with the LIFE program at. Electronic address: http://www.LIFE-worldwide.org.(PubMed)
(130) Prevalence study of genital tract infections in pregnant women referred to health centers in Iran.Mobasheri M, Saeedi Varnamkhast N, Karimi A, Banaeiyan S.(PubMed)
(131)Vaginal infections among pregnant women at Omdurman Maternity Hospital in Khartoum, Sudan Abdelaziz ZA1, Ibrahim ME, Bilal NE, Hamid ME. (PubMed)
(132) Reproductive tract infections among married women in Upper Egypt. Sullam SA1, Mahfouz AA, Dabbous NI, el-Barrawy M, el-Said MM. (PubMed)
(133) Characterization of low molecular weight antimicrobial peptide from human female reproductive tract. Sharma S1, Sethi S, Prasad R, Samanta P, Rajwanshi A, Malhotra S, Sharma M.(PubMed)
(134) Lower genital tract infections in infertile Nigerian women compared with controls.Okonofua FE1, Ako-Nai KA, Dighitoghi MD. (PubMed)
(135) ion of oocyte fertilization by assisted reproductive techniques and increased sperm DNA fragmentation in the presence of Candida albicans: a case report. Burrello N1, Calogero AE, Perdichizzi A, Salmeri M, D'Agata R, Vicari E.(PubMed)
(136) Studies on the significance of positive bacterial semen cultures in male fertility in Nigeria.Onemu SO1, Ibeh IN. (PubMed)
(137) Mycetomatoid infection of the penis by Candida albicans. Mastrolorenzo A1, Giomi B, Cipollini EM, Tammaro R, Decarli N, Cammelli D, Fabiani Tropeano F, Tiradritti L, Difonzo EM, Zuccati G.(PubMed)
(138) Candida albicans epididymo-orchitis and fungemia in a patient with chronic myelogenous leukemia Mark Pimentel, MD, Lindsay E Nicolle, MD FRCPC, and Salman Qureshi, MD FRCPC(PubMed)
(139) Normocalcemic tetany and candidiasis. Galland L.(PubMed)
(140) Interaction of Candida albicans with genital mucosa: effect of sex hormones on adherence of yeasts in vitro. Kalo A1, Segal E.(PubMed)
(141) Response of pathogenic and non-pathogenic yeasts to steroids. Prasad R1, Devaux F, Dhamgaye S, Banerjee D.(PubMed)
(142)Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An in vivo Study. Ganapathy DM1, Joseph S, Ariga P, Selvaraj A.(PubMed)
(143)Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Cenci E1, Romani L, Vecchiarelli A, Puccetti P, Bistoni F.(PubMed)
(144)[Squamous epithelial carcinoma in a 27-year-old patient with cellular immune defect].[Article in German] Kübler A1, Ziegler C, Barth T, Zöller J.(PubMed)
(145)Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines. Rinaldi M1, Perricone C, Ortega-Hernandez OD, Perricone R, Shoenfeld Y. (PubMed)
(146)Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006-2007 and 2012-2013.Kamikawa Y1, Mori Y, Nagayama T, Fujisaki J, Hirabayashi D, Sakamoto R, Hamada T, Sugihara K.(PubMed)
(147)Oxidative and nitrosative stress on phagocytes' function: from effective defense to immune evasion mechanisms. Ferrari CK1, Souto PC, França EL, Honorio-França AC. (PubMed)
#Catnip Extract Increases the Levels of Bax Protein Asssociated with #ProstateCancer Cells Apoptosis, Researchers Say
Kyle J. Norton
Herbal Catnip may have a potential and substantial effect of reducing the risk of pre-malignant cells, caused by slowly changing from normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia'
The plant has been used in herbal medicine as an insect repellent and to treat digestive disorders, children's restlessness and nervousness, fevers, colds, flu, skin irritations that stimulate sweating, promote menstruation, etc.
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Prostate cancer is a medical condition characterized by irregular cell growth in the issues of the prostate.
At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, based on 2012-2014 data, approximately 11.6 percent of men are diagnosed with prostate cancer at some point during their lifetime.
On PC3 and DU145 prostate cell lines, in comparison of the effects of methanol extracts, n-hexane, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity, researchers found that application of ethyl acetate extract compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area.
The ethyl acetate extract also caused the loss of some DNA structure in tested cell lines, in a concentration-dependent manner.
Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor-positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.
Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with a lesser value of IC50 and greater effect than other tested compounds,
The results of these effects were attributed to the activity of PC3 cells which process a property to change its negative androgen receptors profile to positive (PC3AR+)
The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also be associated with the different responses of cells to sex hormones.
Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage and Poly(ADP-ribose) polymerase (PARP).
Caspase 3 cleavage is an important marker associated with the progression of the cancer cell’s entry point into the apoptotic signaling pathway.
Poly(ADP-ribose) polymerase (PARP) plays an essential role in the execution of the cell's apoptosis and is considered an early indicator of apoptosis.
Moreover, researchers also found that the Catnip extract also increased the level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with the release of cytochrome c, an early phase of cell degradation and death.
After taking into account other confounders, Dr. Emami SA, the lead author said, "The semi-polar EtOAc extract of N. cataria induces apoptosis in pc3 cells to compare to DU-145 cells, and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".
Taken together, Catnip and its extract may be considered as a functional food in reducing the risk of Prostate cancer by blocking the entry phase of the onset of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125
Herbal Catnip may have a potential and substantial effect of reducing the risk of pre-malignant cells, caused by slowly changing from normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia'
The plant has been used in herbal medicine as an insect repellent and to treat digestive disorders, children's restlessness and nervousness, fevers, colds, flu, skin irritations that stimulate sweating, promote menstruation, etc.
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Prostate cancer is a medical condition characterized by irregular cell growth in the issues of the prostate.
At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, based on 2012-2014 data, approximately 11.6 percent of men are diagnosed with prostate cancer at some point during their lifetime.
On PC3 and DU145 prostate cell lines, in comparison of the effects of methanol extracts, n-hexane, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity, researchers found that application of ethyl acetate extract compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area.
The ethyl acetate extract also caused the loss of some DNA structure in tested cell lines, in a concentration-dependent manner.
Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor-positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.
Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with a lesser value of IC50 and greater effect than other tested compounds,
The results of these effects were attributed to the activity of PC3 cells which process a property to change its negative androgen receptors profile to positive (PC3AR+)
The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also be associated with the different responses of cells to sex hormones.
Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage and Poly(ADP-ribose) polymerase (PARP).
Caspase 3 cleavage is an important marker associated with the progression of the cancer cell’s entry point into the apoptotic signaling pathway.
Poly(ADP-ribose) polymerase (PARP) plays an essential role in the execution of the cell's apoptosis and is considered an early indicator of apoptosis.
Moreover, researchers also found that the Catnip extract also increased the level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with the release of cytochrome c, an early phase of cell degradation and death.
After taking into account other confounders, Dr. Emami SA, the lead author said, "The semi-polar EtOAc extract of N. cataria induces apoptosis in pc3 cells to compare to DU-145 cells, and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".
Taken together, Catnip and its extract may be considered as a functional food in reducing the risk of Prostate cancer by blocking the entry phase of the onset of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125
#Caffeic Acid and #Greentea's #EGCG Express a Significant Reduction on #Alzheimer's disease #AD, According to Studies
Kyle J. Norton
Green tea may be an integrated form of treatment for patients with Alzheimer's disease through many mechanisms, a recent study proposed.
Green tea, considered as a functional food, linking a number of health benefits has been reported by several renowned research and studies. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But a slice of ginger in the drink will neutralize the yin-over expression in green tea.
Alzheimer's disease is a neuro-degenerative condition of loss or decrease of cognitive and memory functions due to aging.
According to the Maternal and Infant Health, ASL NA 3 SUD, epigallocatechin, and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), found in green tea exerted strong anti-inflammatory and anti-oxidative properties in protection against neuronal damage and brain edema.
The study also stated that green tea may also contribute to reduced risk and treatment of AD by ameliorating chronic viral infection, one of the causes responsible for AD's neuropathology.
Dr. Mandel SA. the lead author and expert in the green tea study said, "Tea drinking may decrease the incidence of dementia, AD, and PD. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders".
Other researchers suggested that the efficacy of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) in reduced risk of AD may be attributed to
1. The antioxidant activity in ameliorating the production of ROS in induced risk of oxidative stress has been found to associate with the production of lipid peroxidation, leading to abnormal deposition of amyloid β (Aβ) peptide
2. Free radical overexpression in aging people is also vulnerable to the imbalance of antioxidants and ROS may have negative direct interaction with proteins, nucleic acids, and other molecules and may also alter their structures and functions in inducing risk AD.
Indeed, as a single ingredient isolated from green tea, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) have been found to cause toxicity in some cases in medical literature. Therefore taking the ingredient in the long term and overdoses may have an implication of liver damage.
In an animal study to evaluate the efficacy of Caffeic acid in AD, mice rats were randomly divided into three groups: i) the control group, ii) the AD model group, and iii) the caffeic acid group, mice fed with the phytochemical expressed a significantly increased learning deficit and cognitive function demonstrated by the Morris water maze task in compared control.
Additionally, fed mice also displayed attenuated oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression involved inflammatory cytokins production and suppressed caspase‑3 activity-induced cell death and other mechanisms in the rats with AD.
Interestingly, the inflammatory process has been shown to have a negative role in an increased risk of AD, by causing neuroinflammation, including brain cells such as microglia and astrocytes, and subsequently in promoting dysfunction and neuronal death. Therefore by suppressing the production of inflammatory cytokins, caffeic acid expressed a significant reduction in AD risk.
The efficacy in the contribution of cognitive improvement following caffeic acid application may be due to its antioxidant activity and restoration of cholinergic functions, as deficiency of cholinergic function has shown to affect cognition, behavior, and activities of daily living
Taking it all together, there is no doubt that the green process is a neuroprotective against the risk and progression of patients with Alzheimer's disease (AD) attributed to some of the major chemical constituents. But intake of a single ingredient isolated from green tea should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma anSciencecience, ISSN 0975-6299.
Sources
Green tea may be an integrated form of treatment for patients with Alzheimer's disease through many mechanisms, a recent study proposed.
Green tea, considered as a functional food, linking a number of health benefits has been reported by several renowned research and studies. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But a slice of ginger in the drink will neutralize the yin-over expression in green tea.
Alzheimer's disease is a neuro-degenerative condition of loss or decrease of cognitive and memory functions due to aging.
According to the Maternal and Infant Health, ASL NA 3 SUD, epigallocatechin, and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), found in green tea exerted strong anti-inflammatory and anti-oxidative properties in protection against neuronal damage and brain edema.
The study also stated that green tea may also contribute to reduced risk and treatment of AD by ameliorating chronic viral infection, one of the causes responsible for AD's neuropathology.
Dr. Mandel SA. the lead author and expert in the green tea study said, "Tea drinking may decrease the incidence of dementia, AD, and PD. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders".
Other researchers suggested that the efficacy of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) in reduced risk of AD may be attributed to
1. The antioxidant activity in ameliorating the production of ROS in induced risk of oxidative stress has been found to associate with the production of lipid peroxidation, leading to abnormal deposition of amyloid β (Aβ) peptide
2. Free radical overexpression in aging people is also vulnerable to the imbalance of antioxidants and ROS may have negative direct interaction with proteins, nucleic acids, and other molecules and may also alter their structures and functions in inducing risk AD.
Indeed, as a single ingredient isolated from green tea, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) have been found to cause toxicity in some cases in medical literature. Therefore taking the ingredient in the long term and overdoses may have an implication of liver damage.
In an animal study to evaluate the efficacy of Caffeic acid in AD, mice rats were randomly divided into three groups: i) the control group, ii) the AD model group, and iii) the caffeic acid group, mice fed with the phytochemical expressed a significantly increased learning deficit and cognitive function demonstrated by the Morris water maze task in compared control.
Additionally, fed mice also displayed attenuated oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression involved inflammatory cytokins production and suppressed caspase‑3 activity-induced cell death and other mechanisms in the rats with AD.
Interestingly, the inflammatory process has been shown to have a negative role in an increased risk of AD, by causing neuroinflammation, including brain cells such as microglia and astrocytes, and subsequently in promoting dysfunction and neuronal death. Therefore by suppressing the production of inflammatory cytokins, caffeic acid expressed a significant reduction in AD risk.
The efficacy in the contribution of cognitive improvement following caffeic acid application may be due to its antioxidant activity and restoration of cholinergic functions, as deficiency of cholinergic function has shown to affect cognition, behavior, and activities of daily living
Taking it all together, there is no doubt that the green process is a neuroprotective against the risk and progression of patients with Alzheimer's disease (AD) attributed to some of the major chemical constituents. But intake of a single ingredient isolated from green tea should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma anSciencecience, ISSN 0975-6299.
Sources
(1) The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice by Cascella M#1, Bimonte S#1, Muzio MR2, Schiavone V3, Cu omo A1. (PubMed)
(2) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective stratAlzheimer'slzheiParkinson'sarkinson diseases by Mandel SA1, Amit T, Weinreb O, Reznichenko L, You dim MB. (PubMed)
(3) Effects of caffeic acid on learning deficits in a model of Alzheimer's disease by Wang Y1, Wang Y2, Li J1, Hua L3, Han B1, Zhang Y1, Yang X3, Zeng Z3, Bai H3, Yin H1, Lou J3.(PubMed)
(4) Caffeic acid attenuates oxidative stress, learning, and memory deficit in intra-cereventricstre ptozotocin-induced experimental dementia in rats by Deshmukh R1, Kaundal M2, Bansal V2, Samardeep2(PubMed).
(2) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective stratAlzheimer'slzheiParkinson'sarkinson diseases by Mandel SA1, Amit T, Weinreb O, Reznichenko L, You dim MB. (PubMed)
(3) Effects of caffeic acid on learning deficits in a model of Alzheimer's disease by Wang Y1, Wang Y2, Li J1, Hua L3, Han B1, Zhang Y1, Yang X3, Zeng Z3, Bai H3, Yin H1, Lou J3.(PubMed)
(4) Caffeic acid attenuates oxidative stress, learning, and memory deficit in intra-cereventricstre ptozotocin-induced experimental dementia in rats by Deshmukh R1, Kaundal M2, Bansal V2, Samardeep2(PubMed).
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