#Coffee Intake Inhibits the #OxidativeInsults Associated with the Protection of Serveral Types of #ChemicalStress, According to Studies

Kyle J. Norton

Coffee and coffee caffeine may have a profound and positive effect in reducing the risk of genotoxicity, caused by environmental toxins, a coffee production company opinionated.

Genotoxicity is an action that causes the alternation of cell DNA due to overwhelming toxins accumulated in the cells. In most cases, the alteration affects the cells' integrity, leading to cancers.

Substances such as radiation and chemicals that cause genotoxicity are called genotoxins.


Highly genotoxic chemicals include the known potent carcinogens benzo(a)pyrene, aflatoxin B1, N-nitroso compounds, and various alkylating agents that directly act on DNA, inducing breakage and cross-linking, and the formation of DNA adducts, abasic sites, oxidative damage, alkylation, and various other DNA lesions(4).

Interestingly, some genotoxins do not directly act on DNA but cause numerical chromosome aberrations during cell division(4).

Furthermore, certain chemicals used in pesticides, food additives, starches, shampoos, and fireproof and crease-proof fabrics may be considered genotoxins as they also cause genetic mutations.

Moreover, automobile exhaust fumes and medicine used for their antibacterial activity and in chemotherapy(5), chemicals from occupational sources, and tobacco may also induce mutations and cancer(6).

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.

In rat liver and primary hepatocytes, regular intake of coffee daily illustrated an enormous effect on cellular antioxidant defenses through regulating exhibited enzymes involved in mRNA and protein expression.

The study also suggested that coffee and coffee caffeine through the expression of detoxifying enzymes GSTs and AKR(in cellular detoxification) also demonstrate significant activities in reduced risk of genotoxicity and cytotoxicity caused by injection of aflatoxin B1 (AFB1).

Dr. Cavin C, the lead author said, "The coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with a protection against various types of chemical stresses".
(Please note that the Nrf2-ARE pathway is an indicator and modulator of oxidative stress)


Other, in the evaluated L5178Y mouse lymphoma cell line to assess the modulatory effects of coffee against genotoxicity induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG), researchers found that
* 3 doses of instant coffee caffeine injection displayed a decrease in genotoxicity following co-treatment of mouse lymphoma cells.

* Coffee caffeine pre-treatment or co-treatment exhibited significant antigenotoxic effects against MNNG(an environmental carcinogen that causes DNA mutation) expression.

* Both caffeinated and decaffeinated instant coffee demonstrated a similar effect against genotoxicity in the experiment samples.

Dr. Abraham SK, the lead author said, " Results from three or five independent experiments demonstrated significant protective effects of caffeinated instant coffee against MNNG-induced DNA damage in the comet assay, a mutation at the Tk locus and chromosomal damage in the cytokinesis-block micronucleus test".

In support of the above analysis, the Swiss Federal Institute of Technology (ETH), in the study of protective effects of coffee against somatic mutation and mitotic recombination induced by chemo drugs, cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE), using standard (ST) and high bioactivation (HB) crosses of the wing spot test in Drosophila melanogaster assays, suggested that in dose depending, coffee injection showed a strong effect in the genotoxicity of URE in the ST and the genetically susceptible HB cross as well as the genotoxicity caused by MMC application.

Dr. Abraham SK, the lead researcher said, "The magnitude of the protective effects of coffee against these three genotoxins was independent of the genotype of the larvae used for treatment, that is it was independent of the bioactivation capacity of these larvae".

The collective information showed definitive support for coffee and coffee caffeine used as a functional food in reduced risk against genotoxic expression, including side effects of chemo medicine used in the treatment of multi types of cancers.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)
(2) Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells by Abraham SK1, Stopper H.(PubMed)
(3) Protection by coffee against somatic genotoxicity in Drosophila: role of bioactivation capacity by Abraham SK1, Graf U.(PubMed)
(4) Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals by Masamitsu Honma
(5) Structure−Activity Relationship Studies of Chemical Mutagens and Carcinogens: Mechanistic Investigations and Prediction Approaches by Romualdo Benigni
(6) Aromatic amines and cancer by Vineis P1, Pirastu R.(PubMed)

#Omega3 Fatty Acids Restore Intestinal Nutrients Transport by Inhibiting the Intestinal Pro-Inflammation Expression, According to Studies

Kyle J.Norton


Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.

Acute inflammation is a short-term condition caused by tissue injury, leading to pain, redness, swelling, and heat in the affected area. depending on the size of the injury. Some patients with acute inflammation may also experience the symptom of loss of function.

In acute inflammation, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of platelets to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.

Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.

However, in people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.


Lipids mediators, derived from the omega-6 polyunsaturated fatty acids (PUFA) are potent enhancers of innate and adaptive immune activation in numerous inflammatory disorders.

Dr. Bennett M, the lead scientist in the examing "Lipid Mediators in Inflammation" wrote, "Lipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA".

In other words, each individual acid arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties which are derived from polyunsaturated fatty acids (PUFAs), plays a selective role in maintaining cellular process depending on the types of fatty acid.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the treatment of inflammatory diseases, researchers examined the effects of n3-PUFA DHA and its derived specialized pro-resolving lipid mediators (SPMs) MaR1, RvD1, and RvD2, on TNF-α inhibition of intestinal sugar and glutamine uptake.


Based on the differentiation,* DHA blocked TNF-α-induced inhibition of α-methyl-D-glucose (αMG) uptake, an analog of glucose, and SGLT1, a glucose transporter, expression in the apical membrane of Caco-2 cells.

* Compared to DHA, SPMs showed the same preventive effect at concentrations 1000 times lower.

* In diet-induced obese (DIO) mice, oral gavage of SPMs, MaR1 reversed the up-regulation of pro-inflammatory cytokines found in the intestinal mucosa of these mice without inducing a reduced intestinal transport of αMG and SGLT1 expression in the DIO mice.

* In Caco-2 cells, EPA, DHA, and the DHA-derived SPMs. also prevent the TNF-α in the inhibition of glutamine uptake.

Collectively, scientists said, " DHA and its SPMs as promising biomolecules to restore intestinal nutrients transport during intestinal inflammation".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of diseases associated with impaired lipid inflammatory mediators, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DHA and its derived lipid mediators MaR1, RvD1 and RvD2 block TNF-α inhibition of intestinal sugar and glutamine uptake in Caco-2 cells by Castilla-Madrigal R1, Gil-Iturbe E1, López de Calle M2, Moreno-Aliaga MJ3, Lostao MP. (PubMed)

#Greentea Inhibts #BladderCancer by Regulating Angiogenetic Effects on Cancer Cells Proliferation, Metastatic Spread, Researchers Say

Kyle J. Norton

Green tea may have a therapeutic and sustainable effect in reduced risk and treatment of bladder cancer, some scientists suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Bladder cancer is a medical condition characterized by irregular cell growth in the issues of the bladder. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistics provided by cancer.net, 90% of people with bladder cancer are older than 55, and the average age of people diagnosed with bladder cancer is 73


In the review of medical literature published online, green tea major catechin EGCG in reduced risk and treatment may be attributed to a number of mechanisms.

In the T24 human bladder cancer cell line, application of the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) induced anti-malignant cell proliferation by modulating the expression of phosphatidylinositol 3' kinase/Akt in activated Bcl-2 family proteins with a function in the regulation of cell death, thus enhancing apoptosis of T24 bladder cancer cell line in dose- and time-dependent manner.

The phosphatidylinositol 3'-kinase/AKT pathway is a crucial regulator of cellular processes including cell proliferation and apoptosis.

Bcl-2 family proteins are a modulator responsible for the regulation of cell apoptosis.

In C3H/HeN mice subcutaneously implanted with MBT-2 murine bladder tumor cells, administration of EGCGs physically attached to the surface of nanogold particles pNG(EGCG-adsorbed pNG) exerted a significant anti-cancer proliferation through induction of apoptosis.

This action of anti-cancer effect was attributed to the mechanism of EGCG-pNG in the activation of caspases which plays an important role in induced cell apoptosis and inflammation through Bcl-family proteins with a function in control apoptosis by activating caspase proteases in governing the space between outer and inner mitochondrial membrane.

Under stress, the mitochondrial pathway or the intrinsic pathway is activated depending on the release of proteins from the intermembrane space of mitochondria.

Caspase cascade, a family of protease enzymes with function in programmed cell death and inflammation.

Additionally, injecting EGCG-pNG directly into the tumor site inhibited tumor expansion through ameliorated the function of vascular endothelial growth factor (VEGF) in stimulating the formation of the new blood vessels in provided nutrients and oxygen for the survival of the cancer site compared to
oral administration of EGCG in stimulated immune function in suppression of cancer progression.

A vascular endothelial growth factor is a signal protein produced by cells in the stimulated formation of blood vessels for cell division and site proliferation.

Based on the information collected,, the prepared EGCG-pNG was more effective than free EGCG in inhibiting bladder tumors in model mice.

More interestingly, bladder tumor induced by N-butyl-(-4-hydroxybutyl) nitrosaminre (BBN) 0.05% solution on 8-week-old female C3H/He mice for 14 or 24 weeks on treatment with or without green tea polyphenols (GTP) expressed a significantly lower rate of tumor invasive frequency of 23.8%; in the group treated with both GTP and BBN in compared to 65.2% in the group treated with BBN alone.

The tumor volume and microvascular density (MVD) as an independent predictor within a tumor. and the connective, functionally supportive framework of a biological cell, tissue, or organ region in the BBN+GTP group was also significantly lower than in BBN-treated mice.

Unbelievably, green tea polyphenols inhibited tumor growth and invasion in mice with established bladder cancer through regulation of angiogenetic effect in suppressing the forming of new blood vessels for the tumor cells proliferation, metastatic spread, as well as providing oxygen and nutrients and removal of waste products of cancer cells without exhibiting anti-carcinogenic effect.

Taken together, green tea extract polyphenols may be considered as an adjunct therapy for reduced risk and used in combination with standard medicine for the treatment of bladder cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins by Qin J1, Xie LP, Zheng XY, Wang YB, Bai Y, Shen HF, Li LC, Dahiya R.(PubMed)
(2) The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles by Hsieh DS1, Wang H, Tan SW, Huang YH, Tsai CY, Yeh MK, Wu CJ. (PubMed)
(3) Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer by Sagara Y1, Miyata Y, Nomata K, Hayashi T, Kanetake H.(PubMed)

#Aloesterol Supplementation Increases #SkinElasticity and Production of Collagen and Hyaluronic Acid Associated with Connective, Epithelial, and Neural Tissues, Researchers Reveal

Kyle J. Norton

Aloe Vera or Aloe Vera supplement may be used to delay skin aging that causes expression of wrinkle, some scientists suggested.
Skin aging is a natural and biological process that changes with age including wrinkles, age spots, and dryness.

As we age, the skin also becomes thinner and loses fat, these conditions increase less plump and smooth. In the case of injury, the skin also takes longer to heal, too.

WrThe wrinkles are a skin degenerative condition caused by the loss of dermis and subcutaneous fat layer underneath the skin, leading to a slight line or fold on the skin, particularly in the face.

An unhealthy diet and lifestyle also are major factors that increase the early onset of skin aging.


Stacey Colino, a freelance Health & Wellness reporter at U.S. News, in the article of "6 Surprising Factors That Can Accelerate the Aging of Your Skin" suggested that consuming lots of highly processed or sugary foods, always sleeping on the same side, being depressed, yo yo diet, long-term intake of certain medications such as corticosteroids, antibiotics, ACE inhibitors, and diuretics and being a frequent flyer are also associated with prevalent risk factors of early aging(6).


Smoking causes overexpression of free radicals that can damage skin cells in facilitated premature wrinkles.

Other causable factors such as stress, gravity, daily facial movement, obesity,..... and even sleep pattern may also have some effects in stimulated premature aging.

According to the University of Paris VI, free radical generation in the skin by UV light and from other sources, such as cellular infiltrations or the xanthine oxidase reaction also may contribute to at least retardation of premature cutaneous aging(4).

In the report “Global Anti-Aging Market Research Report and Forecast to 2017-2022” published by OrbisResearch.com, the writer wrote, "The Global Anti-Aging Market was worth $250 billion in 2016 and estimated to be growing at a CAGR of 5.8%, to reach $331.41 billion by 2021" and "The future growth of the anti-aging market is observed to rely on the advancement and technological development with enhanced efficacy and safety of anti-aging products"(5).

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan. een

The plant is very popular for commercial cultivation due to its health benefits. Herbal Aloe Vera has used in traditional medicine to treat the wound, burn, minor skin infections, sebaceous cysts, diabetes,....... and elevated of cholesterol.

According to the Food Ingredients & Technology Institute, daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin of that may reduce the risk of skin wrinkle.

In a 12-week, randomized, double-blind, placebo-controlled study, in 48 apparently healthy men (age range: 30-59 years; average: 45 years), intake of oral Aloe sterol supplementation after 12 weeks showed a significant improvement of the skin elasticity index in comparison in the baseline value.

Dr. Tanaka M, the lead author said, "Aloe sterol ingestion increased skin elasticity in the photodamaged skin of men aged <46 years, and "No Aloe sterol intake-dependent harmful phenomenon was observed during the intake period".

Furthermore, in vitro, Aloe sterols increased production of collagen and hyaluronic acid, a natural substance in skin response to connective, epithelial, and neural tissues. approximately two-fold and 1.5-fold, and promoted gene expression levels in human dermal fibroblasts.

In fact, daily oral Aloe sterol-containing Aloe vera gel powder (AVGP) significantly reduced facial wrinkles in women aged ≥40 years as well as stimulated collagen and hyaluronic acid production by human dermal fibroblasts.

In support of the above evaluation, intake of Aloe Vera gel enhanced healthy skin through promoting elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores and skin fatigue area F3, the Food Ingredients and Technology Institute 12 weeks study suggested.

Taking all together, there is no doubt that oral administration of Aloe Vera or Aloe Vera supplements may improve skin condition including wrinkle, caused by skin aging, but the quality of amount intake should only be prescribed by related field specialist.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women by Tanaka M1, Misawa E1, Yamauchi K1, Abe F1, Ishizaki C2.(PubMed)
(2) Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial by Tanaka M1, Yamamoto Y, Misawa E, Nabeshima K, Saito M, Yamauchi K, Abe F, Furukawa F.(PubMed)
(3) Aloe sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial by Tanaka M1, Yamamoto Y2, Misawa E1, Nabeshima K1, Saito M1, Yamauchi K1, Abe F1, Furukawa F2. (PubMed)
(4) Free radicals and aging of the skin by Emerit I(PubMed)
(5) Global Anti-Aging Market 2017 is Growing Rapidly and Expected to Reach $331.41 Billion by 2021 – Orbis Research
(6) Stacey Colino, a freelance Health & Wellness reporter at U.S. News, in the article "6 Surprising Factors That Can Accelerate the Aging of Your Skin"

#BlackCarrotCrudeExtract (#BCCE) Promotes Cytoprotective Effect Against ROS in Causing Healthy Cell Damage and Apoptosis, Scientists Say

Kyle J. Norton


Carrots may have a profound and positive effect in reducing the overexpression of reactive oxygen species that cause chronic diseases, through antioxidant activities, some scientists suggested.

An antioxidant is a substance characterized by its function in inhibiting oxidation, especially in balancing the ratio of free radicals and antioxidant levels in the body to prevent the initiation of oxidatively related diseases.

Chronic diseases are conditions that last longer than 3 months and can not cure by medication.
The diseases are most common in the aging population.

The most common chronic diseases are arthritis and cardiovascular diseases such as heart attacks and stroke. Cancer such as breast and colon cancer, and diabetes.

Sadly, in North America, the most common chronic disease is obesity, affecting over 28% of the general population. In other words, 1 in 3 adults is obese, according to a calculation by the BMI index.


The causes of chronic diseases are well established by epidemiological studies. There are a set of risk facts including unhealthy diet, physical inactivity,.... and tobacco use that induce preventable chronic illness through intermediate risk factors such as high blood pressure, and glucose levels, abnormal blood lipids, overweight, and obesity.


The major nonmodifiable risk factors that also cause chronic diseases are age and heredity.


Dr. George E. Hardy, Jr, the lead scientist in the study of "The Burden of Chronic Disease: The Future is Prevention" wrote, "Chronic diseases impose an enormous financial and societal burden on the United States. According to the Centers for Disease Control and Prevention (CDC), chronic diseases today account for 70% of the deaths of all Americans and 75% of this country’s annual health care costs" More importantly, "Unless we take steps now to deal effectively with chronic diseases, our nation is headed for a serious financial and quality-of-life crisis"(4).

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

The efficacy of carrots acting as an antioxidant to protect against oxidation was reported by a number of the institution including Texas A&M University and the University of Messina.


According to the investigation of phenolic antioxidants in three carrots cultivars (Navajo, Legend, and Choctaw) were studied under different wounding intensities (A/W) during storage, researchers found that carrot soluble phenolics exert a significant antioxidant capacity (AOX), and PAL activity to protect against increased with A/W for all cultivars.

In Intense wounding (23.5 cm(2)/g) induced a ∼2.5- and ∼12.4-fold displayed a strongly increased production of soluble phenolics and AOX, respectively, after 4 days compared to the whole and lesser wound carrots through the AOX synthesis of mainly chlorogenic acid (5-CQA) and 3,5-dicaffeoylquinic acid.

These results suggested that intentional carrot wounds may have a potential effect as an inexpensive rich source of phenolic antioxidants for the regular diet (with some resistance from the public), as Dr. Surjadinata BB, the lead author said, " By simply increasing wounding stress intensity, it is possible to enhance the biosynthesis of phenolic antioxidants".

Moreover, according to the investigation of the polyphenolic profile and biological properties of a black carrot crude extract (BCCE) through an in-depth analysis of the main polyphenolic effect in antioxidant and cytoprotective properties.

Black carrot (Daucus carota L. ssp. sativus var. atrorubens Alef.) is a valuable source of carbohydrates, minerals, and vitamins.

The root vegetable contains also high amounts of anthocyanins in the expression of the characteristic of deep-purple color.

Anthocyanins are known as natural dyes used in the food and pharmaceutical industry.

According to the experiment, the application of black carrot crude extract (BCCE) demonstrated a strong antioxidant through free radical scavenging activity, observed in the hydrogen transfer-based assays (ORAC and β-carotene bleaching) and a significant increase in the cell viability.

The increase in the cell viability may be attributed to the extract in stimulated production of antioxidants of itself and antioxidants found in the body tissue of the host inhibited the overexpression of ROS, resulting in balancing the antioxidants and free radical ratio.

Furthermore, BCCE exhibited strong anti-angiogenic activity against free radicals in alternated DNA of healthy cells in the initiation of tumor proliferation, at the highest concentration assayed on the chick chorioallantoic membrane (50μg/egg).


Interestingly, ingestion of black carrot crude extract (BCCE) also promoted a cytoprotective effect against ROS in causing healthy cell damage and apoptosis.


The analysis of the above studies was supported by the joint investigation of purple carrot (PC) as a valuable source of antioxidants in modulating the reactive oxygen species (ROS) level in the gastrointestinal tract conducted by a number of institutes, led by the Poznań University of Life Sciences.


According to the end experiment, the application of purple carrot (PC) showed a strong effect in inhibited colonic cells in situ after allowing passage to the gastrointestinal tract.

At a dose of 1mg/mL, purple carrot exhibited intracellular ROS-inhibitory capacity observed by 18.4% decreased expression of reactive oxygen species ROS.

Moreover, at an inhibited rate of 20.7%, the extract demonstrated a significant protective effect against free radicals in damage to the DNA of colon mucosa cells.

After taking account of other confounders and re-examining the final results, Dr.Olejnik A, the lead scientist said, "PC extract is capable of colonic cells' protection against the adverse effects of oxidative stress".

Taken together, Carrots regardless of color with abundant bioactive phytochemicals may be considered as a functional food in reduced risk, progression, and treatment of oxidative-induced chronic diseases.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Biosynthesis of phenolic antioxidants in carrot tissue increases with wounding intensity by Surjadinata BB1, Cisneros-Zevallos L.(PubMed)
(2) Polyphenolic profile and biological activities of black carrot crude extract (Daucus carota L. ssp. sativus var. atrorubens Alef.) by Smeriglio A1, Denaro M1, Barreca D1, D'Angelo V1, Germanò MP2, Trombetta D1.(PubMed)
(3) Antioxidant effects of gastrointestinal digested purple carrot extract on the human cells of colonic mucosa by Olejnik A1, Rychlik J2, Kidoń M3, Czapski J3, Kowalska K2, Juzwa W2, Olkowicz M2, Dembczyński R2, Moyer MP4. (PubMed)
(4) The Burden of Chronic Disease: The Future is Prevention Introduction to Dr. James Marks' presentation, “The Burden of Chronic Disease and the Future of Public Health” by George E. Hardy, Jr., MD, MPH, Executive Director(PMC)

#Omega3 Fatty Acids Protect the Skeletal Muscle Mass and Improve Cancer in Patients with Unresectable #PancreaticCancer

Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice into the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, as a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.


More precisely, the functions of the pancreas including
* Production of enzymes digest fat, protein, and
carbohydrates.

* production of juices combined with juices from the intestines helps to do the job of breaking down protein, carbohydrates, and fat, therefore, it plays an important role in maintaining good health.

* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer. The 5-year survival rate for stage IA pancreatic cancer is only 14%.

Researchers do not know what causes pancreatic cancer. They don't even know why people with the same health conditions in the same family, are susceptible to pancreatic cancer, while others do not.

The most common risk factors of pancreatic cancer are similar to those of common cancers, including age, family history, gender, ethnicity, smoking, being overweight or obese, and certain medical conditions such as diabetes.

Cancer cachexia is a condition a multifactorial syndrome associated with an ongoing loss of skeletal muscle mass.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the treatment of cancer, researchers examined the effects of omega-3 fatty acids in patients with pancreatic and bile duct cancer.

According to the administration of Racol®, an enteral nutrient formulated with omega-3 fatty acids to patients with unresectable pancreatic and bile duct cancer at 4 and 8 weeks after, pre-administration and administration showed a strong activity that increases skeletal muscle mass at both 4 and 8 weeks.

In other words, Omega-3 fatty acid supplementation protects the skeletal muscle mass associated with cancer cachexia in patients with unresectable pancreatic cancer and may improve cancer.

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the reduction of cancer cachexia in patients with pancreatic cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway by Ding Y1, Mullapudi B2, Torres C3, Mascariñas E4,5, Mancinelli G6, Diaz AM7, McKinney R8, Barron M9, Schultz M10,11, Heiferman M12, Wojtanek M13, Adrian K14, DeCant B15,16, Rao S17, Ouellette M18, Tsao MS19, Bentrem DJ20, Grippo PJ. (PubMed)
(2) Effects of ω-3 Fatty Acid Supplementation in Patients with Bile Duct or Pancreatic Cancer Undergoing Chemotherapy by Abe K1, Uwagawa T2, Haruki K2, Takano Y2, Onda S2, Sakamoto T2, Gocho T2, Yanaga K. (PubMed)

Serum of #Tocopherols Are Associated with a Significantly Related to Lower Risk of #OralCancer, Researchers Show

Kyle J. Norton

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.

Mouth/oral cancer is a medical condition associated with irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection, and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.

Risk factors associated with the onset of mouth cancer are
* Smoking
In the studies, Cancer Prevention Study (CPS) I and II, sponsored by the American Cancer Society (ACS), researchers found that the mortality risk for oral cancer in cigarette smokers is substantially greater than that observed among lifelong never smokers.


* Alcohol drinking
Alcohol drinking is known to promote oral cancer. Oral cancer risk increases if a person is both a heavy smoker and a drinker.

* Chewing tobacco
Maybe as a result of irritation of the mucous membranes of the mouth from chemicals in the tobacco.

* Chewing betel nut
It May be caused by a chemical compound that irritates the mucous membranes of the mouth
* Age
Most cases of oral cancer are diagnosed at ages over the fifties.


Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed, or nut oils, etc.

In finding a potential phytochemical for the treatment of chronic diseases, researchers investigated associations between retinol, α-tocopherol, and β-carotene with the risk of oral cancer.

The comparative cross-sectional study included a total of 240 involving oral cancer patients and healthy individuals in matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS).

According to the analysis,
* Serum levels of retinol and α-tocopherol among cases (0.177±0.081, 1.649±1.670μg/ml) were significantly lower than in controls (0.264±0.137, 3.225±2.054μg/ml) (p<0.005) compared to treatment group.

* Serum levels of β-carotene among cases (0.106±0.159 μg/ml) were lower compared to controls (0.134±0.131μg/ml)

These results suggested that high serum levels of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and α-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer.


After taking other factors into account, researchers said, "High serum levels of retinol and α-tocopherol confer protection against oral cancer risk".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of oral cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) High serum level of retinol and α-tocopherol affords protection against oral cancer in a multiethnic population by Athirajan V1, Razak IA, Thurairajah N, Ghani WM, Ching HN, Yang YH, Peng KN, Abdul Rahman ZA, Mustafa WM, Abraham MT, Kiong TK, Mun YK, Jalil N, Zain RB. (PubMed)