Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 6 July 2023

#Greentea and Its Polyphenols Stablelize the Intestinal Phase and Promote Intestinal Antioxidant Activity, Researchers Say

Kyle J. Norton

Green tea may have a therapeutic and positive effect in enhanced gastrointestinal function in food absorption, some scientists suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to Agriculture and Agri-Food Canada, native catechins found in green tea were not absorbed by the digestive system after intake. The polyphenol accumulated in the intestinal lumen inside the space of a tubular structure where they exhibited significant activity in ameliorated cellular glucose and cholesterol uptake, thus reducing risk in over expression of fasting glucose and lipid accumulation entering the blood stream in the induction of syndromes of abnormally high blood sugar and cholesterol.

The pervaded catechins found approximately, 2-15% in the intestinal levels significantly bound to 37% to plasma HDL through inhibiting the key enzymes involved in lipid biosynthesis and reduced intestinal lipid absorption, thus improving blood lipid profile. the action of cholesterol metabolism.

Further analysis of the unstable condition of polyphenols in the intestinal environment, also found that the transition from the gastric phase to the intestinal phase of green tea extract shows a 50% decrease in the antioxidant activity due to the degradation of polyphenols but the deceased extract still exert a strong effect in the gastrointestinal environment.

However, the intake of whole food milk and cheese in the definition of dairy matrices displayed a significant improvement of polyphenol stability in the intestinal phase and an increase of the antioxidant activity by 29% (cheese) to 42% (milk) compared to non-green tea injection control.

Additionally, administration of green tea also demonstrated strong activity in decreased expression of the stomach secretes pepsinogen, in breaking down milk and cheese protein and fat intake in degraded into their component polypeptide or amino acid and glycerol and fatty acids, respectively in the gastric phase but had no effect in the intestinal phase, thus reducing glucose and fat being absorbed and presented in the blood stream.

The finding showed that green tea polyphenols intake together with dairy products improved antioxidant activity and enhanced the integrity of polyphenols during digestion.

Interestingly, in the evaluated rats fed with selenium-containing green tea (Se-GTE, 1.44 mg selenium/kg dry leaves) and China green tea(CH-GTE, 0.13 mg selenium/kg leaves) and China green tea(CH-GTE) effect in the intestinal micro bacterial activity researchers indicated that oral administration of rat group fed with Se-GTE extract for 6 days exerted a significant increase in caecal counts of lactobacilli and bifidobacteria while significantly reducing the caecal counts of Bacteroides and clostridial bacteria in compared to CH-GTE rat group in slight but not significant increase in the numbers of caecal lactobacilli and bifidobacteria but decreased significantly the numbers of Bacteroides (p < 0.05) and clostridia.

Moreover, rats fed with CH-GTE and Se-GTE showed a 17.2% and 21.3% reduction in the activity of the bacterial enzyme β-glucuronidase, which has been found to contribute to biliary sludge and stone formation and increased risk for colorectal cancer, respectively.

More promisingly, treatment of both CH-GTE and Se-GTE also resulted in 19% and 25.5% increments in the activity of β-glucosidase in reduced beta-D-glucosides and oligosaccharides in released glucose, respectively

Taken together, green tea with abundantly major bioactive polyphenols may be considered a function food in improved gastrointestinal function but reduced absorption of glucose and lipid in the induction of abnormal high fasting blood sugar and cholesterol levels through binding to fat and protein in the gastric phase of digestion.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and BioScience, ISSN 0975-6299.

Sources
(1) Interaction of green tea polyphenols with dairy matrices in a simulated gastrointestinal environment by Lamothe S1, Azimy N, Bazinet L, Couillard C, Britten M.(PubMed)
(2) Simulated gastrointestinal digestion, intestinal permeation, and plasma protein interaction of white, green, and black tea polyphenols by Tenore GC1, Campiglia P2, Giannetti D3, Novellino E3.(PubMed)
(3) The ability of green tea to positively modulate key markers of gastrointestinal function in rats by Molan AL1, Liu Z, Tiwari R.(PubMed)

#Healthyfood #DriedPeas Inhibit the Onset of #Hypertension, #Hyperlipidemia and #Hyperglycemia, According to Studies

Kyle J. Norton

Hypertension, hyperglycemia, and hyperlipidemia are the most prevalent modifiable risk factors for the development of diabetes, cardiovascular diseases, and stroke.
Intake of dried pea and bean fibers daily and regularly may reduce risk and treatment of hypertension, Hyperlipidemia and Hyperglycemia, some scientists suggested.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

1. The Effects of Dried Peas and Hypertension
Hypertension is a chronic condition characterized by abnormally high blood pressure.

According to the Veterans Affairs Medical Center, daily intake of fiber has emerged not only to prevent and treat various types of chronic diseases. but also reduced the risk of hypertension.

Dr. Anderson JW, the lead author said, "Dried beans, oat products, and certain fruits and vegetables are good sources of soluble fiber" and "Current guidelines advise a doubling of dietary fiber intake for Americans. Inclusion of ample servings of fruits and vegetables, whole grains, and dried beans and peas will help individuals meet these guidelines".

Additionally, in the examined iineralocorticoid excess-treated mice with a control diet, high-fiber diet, or acetate supplementation researcher found that high fiber diet not only modified the gut microbiota populations and also increased the abundance of acetate-producing bacteria independently of mineralocorticoid excess and reduced systolic and diastolic blood pressures.

Dr. Marques FZ, the lead researcher said, "The favorable effects of fiber may be explained by the generation and distribution of one of the main metabolites of the gut microbiota, the short-chain fatty acid acetate. Acetate effected several molecular changes associated with improved cardiovascular health and function".

These result demonstrated a significant effect of fibers intake in promoted health gut microbiota in regulating molecular changes associated with improved risk factor related to cardiovascular health and function, including blood pressure.

Other, in the examined cross-sectional studies of dietary intake as one of the major determinants in hypertension development and Dietary Approach to Stop Hypertension and the risk of incident hypertension in a large cohort study including the incidence of hypertension among 80 426 French adults, researchers at the joint study led by the Paris-Descartes University found that
1. During a mean follow-up of 3.4±2.1 years, 2413 cases of incident hypertension were documented
2. Fiber intake displayed a strong effect in reduced risk of hypertension with relative odd risk of 0.81 in compared to the baseline.
3. Adopting a global healthy diet associated to several nutritional factors intake may be one of the best solution in reduced hypertensive incidence.

2. The Effects of Dried Peas on Hyperlipidemia

Hyperlipidemia is a condition characterized by high levels of cholesterol in the bloodstream.

In a study of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomized assigned to a high-fiber bean-rich diet that achieved mean (SD) fiber intakes of 35.5 (18.6) g day for women and 42.5 (30.3) g day for men, or a low-carbohydrate diet, researchers found that
1. High bean fiber intake showed a better weight loss and weight control in compared to low carbohydrate diet group.
2. Intake of bean fiber group expressed a significant decrease of Low-density lipoprotein (LDL)-cholesterol and total cholesterol levels compared to the other group.

Dr. Tonstad S, the led author said, "A high-fibre bean-rich diet was as effective as a low-carbohydrate diet for weight loss, although only the bean-rich diet lowered atherogenic lipids".

Additionally, in dyslipidemia rats study to evaluate the effects of grain-bean package, dietary fiber (DF) extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase (FAS) activity in high-fat, high-cholesterol feeding by randomly assigned into normal control group, hyperlipidemia model group, grain-bean package group, grain-bean package DF group and grain corn group, researchers after adjusting to other risk factors filed the following results
1. Rats in the hyperlipidemic model group showed increased total cholesterol (TC), triglyceridaemia (TG), high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose (FBG) in compared to groups.

Compared to the hyperlipidemic model group, the grain-bean package group, grain-bean package DF group, expressed significantly decreased total cholesterol (TC), triglyceridaemia (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose, and significantly increased HDL-C levels.

The results of these findings demonstrated that dietary fiber can improve blood lipids levels indyslipidemic subject, decrease FAS activity and regulating SREBP-1c mRNA in glucose metabolic expression.

3. The Effects of Dried Peas on Hyperglycemia

Hyperglycemia is a medical condition characterized by abnormal high levels of glucose circulated in the bloodstream.

Dried peas, a good sources of protein and fiber, is one of many rich-protein recommended for vegetarian.

Together with a low glycemic index, the peas may be considered as a high-fiber foods for daily carbohydrate intake in prediabetes.

Evidences of studies showed that a low-glycemic load meal containing psyllium soluble fiber is significantly improves the breakfast postprandial glycemic, insulinemic in adults with Type 2 DM.

In the study to compare the glycemic and insulinemic responses to 3 different meals based on dried peas, potatoes, or both in patients with type 2 diabetes, intake of the pea meal expressed a significant in tine delay of the increased postprandial plasma glucose and insulin concentrations, in compared to other meal.

Since carbohydrate counting in dried peas has been disregarded, the nutrient-dried peas should be included in the consumption of low-glycemic, high-fiber foods at the expense of high-glycemic, low-fiber foods for prediabetes.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources

(1) Health benefits and practical aspects of high-fiber diets by Anderson JW1, Smith BM, Gustafson NJ.(PubMed)
(2) High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice by Marques FZ1, Nelson E2, Chu PY2, Horlock D2, Fiedler A2, Ziemann M2, Tan JK2, Kuruppu S2, Rajapakse NW2, El-Osta A2, Mackay CR2, Kaye DM1(PubMed)
(3) Individual and Combined Effects of Dietary Factors on Risk of Incident Hypertension: Prospective Analysis From the NutriNet-Santé Cohort by Lelong H1, Blacher J2, Baudry J1, Adriouch S1, Galan P1, Fezeu L1, Hercberg S1, Kesse-Guyot E1.(PubMed)(4) A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(5) [Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats].[Article in Chinese] by Liu Y, Zhai C, Sun G, Zhang H, Jiang M, Zhang H, Guo J, Lan X.(PubMed)
(6) Evaluation of a high-fiber diet in hyperlipidemia: a review by Ullrich IH.(PubMed)(7) Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus by Clark CA, Gardiner J, McBurney MI, Anderson S, Weatherspoon LJ, Henry DN, Hord NG.(PubMed)
(8) Comparison of the effects of dried peas with those of potatoes in mixed meals on postprandial glucose and insulin concentrations in patients with type 2 diabetes by Schäfer G, Schenk U, Ritzel U, Ramadori G, Leonhardt U.(PubMed)

Healthyfoods Promote the Immune System Through Their #Antiinflammatroy and Antibacterial Activities, Researchers Suggest

Kyle J. Norton

Detoxification is a natural process in the removal of toxic substances from the human body, mainly carried out by the liver and kidney.
However, prolonged period exposed to toxins may lead to organ failure, causing a disruption of hormone production, damage to other organs, and a weakening immune system.

1. Spinach
Besides being rich in vitamins A, E, and C, minerals such as iron, potassium, magnesium, zinc, and calcium are vital for a healthy heart. it also contains antioxidants, lutein, and beta carotene with the function in strengthen immune defense against the forming of free radicals.

People with kidney disease should not eat spinach, due to high oxalate, without drinking a lot of water or juice intake of spinach may increase the risk of forming kidney stones.

According to the study by the University of Tuscia, spinach exerted detoxifying effect in Chlorosis develops in Spinacia oleracea L. plants against exposure to Cd in the basal leaves through phytochelatin production and the nitrogen and sulfur metabolic pathways as dead leaves detach from the plant, they carry away the sequestered Cd(1).

Furthermore, in the model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo, researchers found that the application of chlorophyll isolated from spinach enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway in regulated aging progression through detoxification and antioxidant activities(2).

2. Broccoli
Broccoli is high in vitamin C, an antioxidant with properties in reduced inflammation and inhibited forming of free radicals caused by toxins in our body.

Study shows that some of the chemicals such as indole 3, selenium, and diindolymethane exerted anti-cancer properties by preventing and repairing DNA damaging cells.

According to a study by the Research and Development Division, Kagome Co., Ltd., broccoli sprout extract (BSEx) expressed a significant liver protective effect caused by various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis, on liver gene expression and acute liver injury in the rat(3).

Additionally, 3-methylsuphinylpropyl and 4-methylsulphinylbutyl glucosinolates. isolated from broccoli demonstrated strong activity in an enhanced ability to induce phase 2 detoxification enzymes in mammalian cells(4).

3. Garlic
Garlic is a supernatural food with a proven record of preventing heart diseases, lower cholesterol levels, elevating blood pressure as well as increasing the transportation of oxygen, and stimulating the production of insulin if needed.

Allicin, an antibody isolated from garlic reduced inflammation and fought off degeneration caused by viruses, and bacteria by strengthening our immune system.

The sulfur element processed a rejuvenating property by increasing the function of the liver in removing toxins.

According to Kagoshima University, sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells(5).

Moreover, in the rat model NDEA-induced hepatocarcinogenesis, researchers found that application of garlic oil (GO) inhibited the infectious cells through activated changes of hepatic phase Ⅰ detoxified enzymes (including cytochrome P450 enzyme (CYP) 2E1, CYP1A2 and CYP1A1) and phase Ⅱ detoxified enzymes (including glutathione S transferases (GSTs) and UDP- Glucuronosyltransferases (UGTs))(6).

4. Green tea
Green tea processes the highest antioxidants compared to other foods with the same volume.

In the study, 70 rats were randomly assigned into 4 groups of 10 and studied over 2 months. Group 1: Normal diet and tap water; Group 2: 10 mg/kg intraperitoneal lead acetate weekly over 8 weeks; Group 3: Lead acetate + 100 mg/kg green tea, Group 4: Extract green tea, researchers found that green tea treated group inhibited lead exposure observed by weight change and lowest sperm abnormalities in compared to lead group with no treatment(7).

In redox-sensitive transcription factor, nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2) aspects, application of green tea EGCG, exhibited chemoprevention and cytoprotection in modulated Nrf2-mediated cellular events through its ability in regulated the expression of antioxidant proteins to protect against oxidative damage triggered by injury and inflammation(8).

5. Tomato
alpha and beta carotene found abundantly in tomatoes strengthen the immune system in fighting off inflammation from bacteria and viruses in initiated chronic diseases.

Lycopene, a powerful pigment phytochemical inhibited free radicals to facilitate cytotoxicity in the induction of cell damage and apoptosis.

According to the joint study led by Washington State University, lycopene isolated from tomato exerted its host protective effects in the modulation of Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory, and other cytoprotective mechanisms(9),

Similar to garlic, lycopene also activated changes of hepatic phase Ⅰ detoxified enzymes and phase Ⅱ detoxified enzymes against PAH-induced toxicity.

Taken together, intake of the above food daily and regularly may have profound and positive effects in promoting optimal health through cleansing the body of toxins. However, intake of a supplement of the above foods should be taken with exceptional care as acute liver toxicity was reported in some medical literature.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Does the different proteomic profile found in apical and basal leaves of spinach reveal a strategy of this plant toward cadmium pollution response? by Fagioni M1, Zolla L.(PubMed)
(2) Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan by Wang E1, Wink M1(PubMed)
(3) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury by Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y1.(PubMed)
(4) Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells by Mithen R1, Faulkner K, Magrath R, Rose P, Williamson G, Marquez J.(PubMed)
(5) Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells by Chang HS1, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O.(PubMed)
(6) Garlic oil attenuatednitroso diethylamine-inducedd hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes by Zhang CL1, Zeng T, Zhao XL, Xie KQ.(PubMed)
(7) Survey of the detoxification effect of green tea extract on the reproductive system in rats exposed to lead acetate by Sha'bani N1, Miraj S2, Rafieian-Kohpayei M3, Namjoo AR4(PubMed)
(8) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG by Na HK1, Surh YJ.(PubMed)
(9) Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raisehealth-promotingoting factors byPall ML1, Levine S2.(PubMed)

#GreenTea's #Polyphenols EGCG Exerts Anti-Inflammatory Activity Against the Risk of #AutoimmuneHepatitis, According to Studies

Kyle J. Norton

Green tea may have a therapeutic and positive effect in reduced risk and treatment of autoimmune hepatitis, some scientists suggested.

The result of green tea EGCG efficacy in induction of BNIP3 to decrease expression of concanavalin A (ConA) in the reduction of numbers of infectious cell proliferation was attributed to the IL-6/JAK/STAT3 signaling pathway which plays an important role in the mechanisms in exhibited green tea EGCG antioxidant activity in blocking infectious cells migration and invasion in exhibited hepatoprotective effect.

In other words, said, Dr. Li S, the lead scientist "EGCG attenuated liver injury in ConA-induced hepatitis by down-regulating IL-6/JAKs/STAT3/BNIP3-mediated apoptosis and autophagy".

Further differentiation also found that green tea EGCG administration inhibited the immune overreaction and pathological damage by decreased expression of inflammatory cytokines induced by Tumor necrosis factor (TNF), tumor necrosis factor-alpha, a cell signaling protein (cytokine) in activated systemic inflammation in the acute phase infection.

Additionally, green tea also modulated the inflammatory factors, interleukin 6 (IL-6), the pro-inflammatory cytokines, and anti-inflammatory Cytokins promptly and transiently produced in response to infections and tissue injuries and interferon-gamma (IFN-γ), a cytokine that plays an important role in inducing and modulating immune responses to the infectious tissue, as well as cytokine interleukin-1β (IL-1β), a key mediator of the inflammatory response in protected body against pathological invasion.

Taken together, green tea and its bioactive Epigallocatechin-3-gallate EGCG may be considered a functional food to reduce risk and used in combination with standard therapy for the treatment of autoimmune hepatitis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3. by Li S1, Xia Y1, Chen K1, Li J1, Liu T1, Wang F1, Lu J1, Zhou Y1, Guo C1.(PMC)

#GreenTea Consumption and Greentea Extract #EGCG Reduces the Risk of #CardiovascularDiseases and #Diabetes Acordingly, Researchers say

Kyle J. Norton

Green tea containing bioactive polyphenols may have a strong implication in reduced risk and treatment of cardiovascular disease, some scientists postulated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Cardiovascular diseases are chronic medical conditions characterized by narrowed or blocked blood vessels that can lead to a heart attack including chest pain (angina) or stroke.

According to statistics, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.

In the differentiation of green tea bioactive polyphenols epigallocatechin gallate or EGCG in risk of cardiovascular disease researchers at the joint study led by the Colorado State University found that application of EGCG activated the expression of the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor in the stimulated transcription of antioxidative genes in the protection of the cell against oxidative stress in induction of CVD.

Compared to statins, conventional medicine may be effective in reducing heart attacks and strokes in people at moderate and high risk but it can also cause cancers and multi-drug resistance cancer, EGCG ameliorated the risk of CVD without giving rise to adverse effects.

Further analysis of EGCG efficacy in risk of cardiovascular disease and metabolic syndrome by searching literature published online in major scientific databases, from 1995 to 2017, scientists found that EGCG exhibits a wide range of therapeutic properties including those associated with the inhibition of LDL cholesterol in reduced risk of plague accumulated in the arterial wall in elevated risk of atherosclerosis, attenuated angiotensin II (AngII) through inhibiting transcription factor NF-κB in induced abnormal enlargement, or thickening of the heart muscle, and reduced risk of highly oxidative enzyme myeloperoxidase(MPO) activity in promoted myocardial infarction, as level of myeloperoxidase(MPO) is considered as a biomaker used in assessment of risk of heart attack.

Additionally, EGCG also exerted significant and profound effects in ameliorating the risk of diabetes through lowering plasma glucose and glycated hemoglobin levels, inhibiting pro-inflammatory factors in elevated inflammation in the early phase of acute infection and chronic infection as well as blocking expression of ROS in stimulated free radical chain reaction through its antioxidant activity.

Dr. Eng QY, after taking into account other confounders, said, "EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases".

Moreover, in a total of 9 studies including 259,267 individuals satisfied the criteria and guideline included in the meta-analysis. by examining published literature in evaluated the association between green tea consumption, CVD, and ischemic related diseases. up to October 2014, researchers indicated that for a nongreen tea drinker, risk of CVD was 1.19, intracerebral hemorrhage was 1.24 and cerebral infarction was 1.15 compared to people who drank <1 cup green tea per day.

Not surprisingly, people who drank 1-3 cups of green tea per day had a reduced risk of myocardial infarction 0.81, and stroke 0.64 compared to those who drank <1 cup/day and who drank ≥4 cups/day had a reduced risk of myocardial infarction of 0.68 in compared to those who drank <1 cup/day.

And for people who consumed ≥10 cups/day of green tea were also shown to have lower LDL in compared to a group who drank <3 cups/day.

Dr. Pang J, the lead author at the final stage of the experiment said, "(The) meta-analysis provides evidence that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular and ischemic related diseases".
The results finding of all studies confirmed that consumption of green tea is associated with favorable outcomes with respect to the risk of cardiovascular disease as well as the expression of various serum markers in the compilation of how green tea initiated protective activity against CVD.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(*) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases by Eng QY1, Thanikachalam PV1, Ramamurthy S2.(PubMed)
(*) The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.
Smith RE1, Tran K2, Smith CC3, McDonald M4, Shejwalkar P5, Hara K6.(PubMed)
(1) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)

The #HealthBenefits of #Herbal #Alfalfa and #AlfafalSeeds, According to Studies

Kyle J. Norton

A. Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds make medicine has been used in traditional medicine for thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.

B. Ingredients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11. Vitamin E
12. Vitamin K

C. The 8 Health Benefits Include
1. Antioxidant
In a study of measurements of pH, water holding capacity, color, oxymyoglobin content, TBARS, and oxidation-reduction potential in evaluating the effects of a dietary protein-xanthophylls (PX) concentrate of alfalfa to turkey diets conducted by the University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland. (1), researchers found that TBARS and oxidation-reduction potential values suggested that the inclusion of the concentrate in turkey diets acts as an antioxidant in the raw meat.

2. Lower Blood Cholesterol
In a study to test the effect of Alfalfa used in traditional medicine to treat high blood cholesterol conducted by Malinow MR, McLaughlin P, Stafford C.(2), in 3 human volunteers during ingestion of diets containing alfalfa seeds (AS) for 3 weeks, researchers found that Plasma cholesterol concentrations were reduced and No signs of toxicity were detected through serum determinations of multiple parameters. The ingestion of AS in rats decreased the concentration of plasma cholesterol, reduced intestinal absorption of exogenous and endogenous cholesterol, and increased fecal biliary excretion.

3. Hyperlipoproteinemia
In a study of Fifteen patients with hyperlipoproteinemia (HLP), types IIA (n = 8), IIB (n = 3), and IV (n = 4) were given 40 g of heat-prepared alfalfa seeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged diet, conducted by Mölgaard J, von Schenck H, Olsson AG.(3), found that patients with type II HLP alfalfa treatment caused after 8 weeks a maximal lowering of pretreatment median values of total plasma cholesterol from 9.58 to 8.00 mmol/l (P less than 0.001) and low-density lipoprotein (LDL) cholesterol from 7.69 to 6.33 mmol/l (P less than 0.01), which corresponds to decreases of 17% and 18%, respectively. The maximal decrease was 26% in total cholesterol and 30% in LDL cholesterol. In two patients with hypercholesterolemia, the LDL cholesterol decreased by less than 5%. Apolipoprotein B decreased in the same period from 2.17 to 1.43 g/l (P less than 0.05) in type II HLP, corresponding to a 34% decrease, whereas apolipoprotein A-I did not change. Body weight increased slightly during the first 4 weeks of alfalfa treatment (P less than 0.001) probably because of the caloric content in the alfalfa seeds. After cessation of treatment, all lipoprotein concentrations returned to pretreatment levels. We conclude that alfalfa seeds can be added to the diet to help normalize serum cholesterol concentrations in patients with type II HLP.

4. Disease of autoimmune
In a study of five groups of 12-week-old female mice were per oral treated with vehicle (control), lyophilized AS (550 mg wt/kg BW), ASEA (ASEA, 25 mg/kg BW), coumestrol (CUM, 0.075 mg/kg BW) and tamoxifen (TAM, 0.375 mg/kg BW) as the positive control, conducted by Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan (4), researchers found that alhalfa decreased the disease severity, increased survival and life span of the autoimmune-prone MRL-lpr/lpr mice, suggesting a potential of ASEA in the treatment of autoimmune diseases.

5. Anti-inflammatory activity
A study of anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA) in ice conducted by the College of Life Science, National Taiwan University, Taipei, Taiwan, Republic of China. (5), researchers found significantly higher survival rates than the control group and suggest that ASEA supplementation can suppress the production of pro-inflammatory cytokines and alleviate acute inflammatory hazards.

6. Systemic lupus erythematosus
In experimental studies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa) presented conducted by Oregon Health Sciences University, Portland (6), researchers indicate that a potentially toxic and immunoregulatory role of L-canavanine in the induction of systemic lupus-like disease in primates.

7. Menopause symptoms
In a study of Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity, conducted by the University of Illinois at Chicago (7), researchers found that estrogenic components of plant extracts can be identified using assays for estrogenic activity along with screening and identification of the active components using ultrafiltration LC-MS. These data suggest a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.

8. Neuroprotective activity
In a study of the neuroprotective effect of methanol extract of Medicago sativa (MS, Alfalfa) on ischemia and reperfusion-induced cerebral injury in mice, conducted by Institute of Pharmacy, Solan 173 223, India. (8)found that suggest that treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity.

D. 2 Side effects
1. High amount of vitamin K may reduce the effectiveness of anticoagulant medicine(9)
2. Causing additive effects for women who are under estrogen replacement therapy or taking the oral contraceptive pill(10).

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) "Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physicochemical properties of turkey breast and thigh muscles during aging" by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER., posted in PubMed
(2) "Alfalfa seeds: effects on cholesterol metabolism." Posted in PubMed
(3) "Alfalfa seeds lower low-density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia", posted in PubMed
(4) " The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice" by Hong YH, Huang CJ, Wang SC, Lin BF., posted in PubMed
(5) "Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo" by Hong YH, Chao WW, Chen ML, Lin BF., posted in PubMed
(6) "Dietary amino acid-induced systemic lupus erythematosus" by Montanaro A, Bardana EJ Jr., posted in PubMed
(7) "Evaluation of the estrogenic activity of plant extracts for the potential treatment of menopausal symptoms" by Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL., posted in PubMed
(8) "Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult" by Bora KS, Sharma A., posted in PubMed
(9) Interaction Between Dietary Vitamin K Intake and Anticoagulation by Vitamin K Antagonists: Is It Really True? A Systematic Review by Francesco Violi, MD, Gregory YH Lip, MD, Pasquale Pignatelli, MD, and Daniele Pastori, MD, Monitoring Editor: Xiwen Cheng(PMC)
(10) Alfalfa(Rexall Pharma Plus)

The #HealthBenefits of Soysauces, Scientists Say

Kyle J. Norton

Too much salt intake has been proven to be a major cause of hypertension, leading to increase risk factors for heart disease and stroke.
Some researchers also found that too much salt intake is associated with a higher probability of developing kidney diseases and stomach cancer as well as an increasing risk of immune dysfunction.

According to statistics, from 2011 to 2012, the average daily sodium intake among U.S. adults was 3,592 mg far more than the max of 2300 mg recommended by the FDA.

According to the joint study led by Chonbuk National University, Korean low salt fermented soy sauce with yeasts in production of high ethanol and 3-methyl-1-butanol for bacterial nilation is a balance of more complex and richer flavors with an identical flavor profile pattern to that obtained from high salt soy sauce(1).

Dr. Song YR, the lead scientist said, "Using functional yeast cultures offers a technological option to manufacture salt-reduced soy sauce while preserving its typical sensory characteristics without affecting safety"(1)

Contrary to general belief, soy sauce was found to lower the risk of hypertension by inhibiting the activity of an angiotensin I-converting enzyme (ACE)(2) which is needed to constrict our blood vessels[1].

The information findings suggested that Korean low-salt fermented soy sauce may be a good replacement for salt daily without affecting the taste of high salt intake individuals as well as reducing the risk of hypertension.

Here are the health benefits of Korean low-salt fermented soy sauce

A. Health benefits according to studies
[2]. Cardiovascular health
The investigation of dietary proteins and their effect in heart diseases found that a direct cholesterol-lowering effect of proteins has not been shown. Despite earlier research indicating that soy protein has cardioprotective effects as compared to other proteins, these observations have not been confirmed by randomized placebo-controlled trials. However, most experts recommend the consumption of foods rich in plant proteins as alternatives to meat and dairy products rich in saturated fat and containing cholesterol, according to "Dietary proteins and atherosclerosis" by Darioli R.(a)

[3]. Perennial allergic rhinitis (PAR)
The study of isolated a halophilic lactic acid bacterium, Tetragenococcus halophilus Th221, from soy sauce moromi and its effect on serum total immunoglobulin E, found that The change in serum total immunoglobulin E improved significantly at the end of the trial compared with the beginning in this group (p < 0.05). The safety of Th221 treatment was confirmed by laboratory tests and inspection of the general condition of each subject and concluded that Th221 can be expected to safely improve the symptoms of PAR, according to "Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy saucemoromi for perennial allergic rhinitis" by Nishimura I, Igarashi T, Enomoto T, Dake Y, Okuno Y, Obata A.(b)

[4]. Anti-allergic activities
The assessment of oral supplementation of Shoyu polysaccharides (SPS) and its effective intervention for patients with perennial allergic rhinitis found that evaluation of the medication's effectiveness after 4 weeks of treatment showed significant differences between the SPS- and placebo-treated groups (p<0.05). In conclusion, SPS of soy sauce improved the quality of life for patients with perennial allergic rhinitis, and soy sauce would be useful in an anti-allergic therapy utilizing everyday foods, according to "Quality of life improvement with soy sauce ingredients, Shoyu polysaccharides, in perennial allergic rhinitis: a double-blind placebo-controlled clinical study" by Kobayashi M, Matsushita H, Shioya I, Nagai M, Tsukiyama R, Saito M, Sugita T, Sugimura T, Yamamoto K.(c)

[5]. Breast cancer
The analysis of Shoyu and the gastric mucosa of the rat found that the animals given shoyu were smaller than the controls; 15 intact rats receiving the sauce were healthy at 33 months compared with 7 controls. Only 9 of 50 operated rats lived 33 months. Breast tumors developed in 10 control rats but in none given shoyu. The distribution of other tumors was the same,... and concluded that Shoyu did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity. Long-term use was associated with gastric mucus loss and nuclear changes in a few rats, occasionally with mild gastritis. according to "Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat" by MacDonald WC, Dueck JW.(4)

[6]. Hypolipidemic effect
In the observation of Soy sauce (Shoyu), a traditional Japanese fermented seasoning and its effect on cholesterol levels found that in a 4-week randomized, double-blind, placebo-controlled parallel group study, hyperlipidemic men (TG >150 mg/dl) were treated with 600 mg of SPS (n=15) or placebo (n=15) daily. After 4 weeks, serum TG levels in the SPS-treated group were significantly (P<0.05) lower than the baseline (0 weeks). In conclusion, SPS of soy sauce reduces lipid absorption, and soy sauce is a potentially promising seasoning for the treatment of hyperlipidemia through food, according to "Hypolipidemic effect of Shoyu polysaccharides from soy sauce in animals and humans" by Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y, Matsuura T.(e)

B. Health benefits according to concentration
[7]. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(1)

[8]. Manganese
Manganese plays a vital role in the proper and normal growth of human bone structure (according to the study of "Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants" by Pabbruwe MB, Standard OC, Sorrell CC, Howlett CR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15109850)), it also helps to reduce the risk of cancer, (according to the study of "The effects of 3, 4 or 5 amino salicylic acids on manganese-induced neuronal death: ER stress and mitochondrial complexes" by Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21477646 researchers indicated that the salicylate analogs and the antioxidants did not mediate ER stress in this model. The salicylate analogs reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn. Taken together, the 3, 4, and 5 ASA worked in a similar way, regulating the Mn-induced mitochondrial dysfunction and protecting cells.

[9]. Protein
Protein is the important building block of bones, muscles, cartilage, skin, and blood, it also enhances the nervous system in information transmission between cells and cells of the other parts of the body, thus reducing the risk of nervous tension, (according to the study of "The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function" by Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME, Loll F, Richard EM, Mazzocco C, Racca C, Oliet SH, Abrous DN, Montcouquiol M, Sans N, posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20660256)

[10]. Niacin or vitamin B3
Niacin or vitamin B3 is important in the production of energy in the metabolism of carbohydrates, it is also essential for DNA repairing, according to the study of `Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow by Kostecki LM, Thomas M, Linford G, Lizotte M, Toxopeus L, Bartleman AP, Kirkland JB., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17618655), production of steroid hormones in the adrenal gland, improving blood circulation and lowering the bad cholesterol (LDL) levels., according to the study of `Lowering LDL cholesterol with margarine containing plant stanol/sterol esters: is it still relevant in 2011?` by Doggrell SA., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21296266)

C. Other health benefits
[11]. Cholesterol
Certain studies found that certain types of soy sauce (popular in Chinese cookery) have been shown to reduce the levels of bad cholesterol (LDL) because of the existence of large amounts of isoflavones, so choose your soy sauce wisely, according to the study of `Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17413118)

[12]. Isoflavones
Isoflavones is one of the weak estrogen that can compete with estrogen for the same receptor sites, as it decreases the health risks of excess estrogen, promoting a healthy menstrual cycle, and reducing the risk of cancers caused by high levels of strong estrogen., according to the study of `Red clover and soy isoflavones-an in vitro safety assessment by Reiter E, Gerster P, Jungbauer A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21801124), researchers wrote that
Isoflavones and plant extracts significantly reduced the proliferation activity of the treated cancer cell lines.

[13]. Riboflavin
Riboflavin or vitamin B2 is important for the production of energy in the metabolism of fats, carbohydrates, and proteins due to its coenzymes, flavin adenine dinucleotide, and Flavin mononucleotide properties, it also is the best natural element for treating migraines and muscle pain reliever used together with magnesium, according to the study of `Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial by Schoenen J, Jacquy J, Lenaerts M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/9484373)

[14]. Magnesium
Magnesium helps to maintain the right ratio with calcium, thus aiding the digestive system in the absorption of calcium, according to the study of `Associations of calcium and magnesium in serum and hair with bone mineral density in premenopausal women by Song CH, Barrett-Connor E, Chung JH, Kim SH, Kim KS., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17848724) it also reduces the risk of irregular heartbeat and impairs glucose tolerance, according to the study of `Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in postmenopausal women by Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17536123)

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Effects of indigenous yeasts on physicochemical and microbial properties of Korean soy sauce prepared by low-salt fermentation by Song YR1, Jeong DY2, Baik SH3.(PubMed)
(2) Purification and identification of an angiotensin I-converting enzyme inhibitor from soy sauce.
Kinoshita E1, Yamakoshi J, Kikuchi M(PubMed)
(a) http://www.ncbi.nlm.nih.gov/pubmed/22139566
(b) http://www.ncbi.nlm.nih.gov/pubmed/19240374
(c) http://www.ncbi.nlm.nih.gov/pubmed/15492861
(d) http://www.ncbi.nlm.nih.gov/pubmed?term=Shoyu%20and%20breast%20cancer
(e) http://www.ncbi.nlm.nih.gov/pubmed/18813866
(1) http://www.ncbi.nlm.nih.gov/pubmed/19539268