The Anti #ProstateCancer #Wholefoods

Kyle J. Norton

The widespread prostate cancer once considered a disease of aging males, now has become a major concern of governments and the scientific community in South East Asia with the tendency to affect an even younger age population.

Evidence in the Far East's recent diet suggested, over consuming bad fats at any time in history accompanied by an unhealthy diet and lifestyle may be the possible causes of the disease, linked to the economic prosperity over the last 3 decades.

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue.

At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Most prostate cancers are slow growing. And Enlarged prostate and prostate cancer in most cases are detected during physical (rectum) exams.

Some researchers suggested that certain abnormal expressions of hormones may have a strong effect in increased risk of prostate cancer, including high levels of hormone androgen and insulin-like growth factor-1 (IGF-1).

In other words, patients with prostate cancer are linearly associated with high levels of hormonal testosterone and insulin-like growth factor-1 (IGF-1).

Although genetic mutation may have a direct effect on induced prostate cancer incidence, such as BRCA1, BRCA2, MSH2, and MLH1, the direct causes of prostate cancer are still debatable.

However, there are some risk factors that have significant impacts to induce the early onset of the disease.

The list includes age, family history, race, low levels of vitamin D in the blood, excessive alcohol drinking, obesity,..... and enlarged prostate.

Foods That Kill Prostate Cancer Cells include
1. Flaxseed
Flaxseed is native to the region of the eastern Mediterranean to India and is also known as common flax or linseed.

Flax is an erect annual plant that can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.

Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer cell proliferation via vascular endothelial growth factor(VEGF)-associated pathways(76). And, a diet supplemented with 5% flaxseed inhibited the growth and development of prostate cancer in the TRAMP model(77) and lowered prostate cancer proliferation rates associated with biological alterations(78).

2. Vegetable oil
Vegetable oil is a triglyceride extracted from vegetables.

Increased levels of MUFA-rich vegetable oil((including olive oil, canola, or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79).

Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model. And, 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).

3. Honey
The rich golden liquid is a miraculous product made by bees using nectar from flowers. The liquids are considered as one healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manner (81).


4. Chickpea
Garbanzo beans also known as chickpeas are an edible legume of genus Cicer, belongings to the family Fabaceae, with high sources of protein and minerals, and native to the Middle East.

7 protease inhibitor concentrates (PICs) isolated from chickpeas showed a significant inhibition of the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).

5. Olive oil
Extra virgin olive oil (EVOO), was found to significantly affect the growth of HCT 116 tumors xenografted in athymic mice(83).

And polyphenols, found in extra virgin olive oil (EVOO) exerted chemopreventive effects towards different organ-specific cancers, through disruption of the overall process of carcinogenesis by inhibition of DNA synthesis and ROS production, regulation of cell cycle arrest and modulation of survival/proliferation pathways(84).

Moreover, polyphenols application can directly interact with specific steps and/or proteins regulating the apoptotic process in different ways, depending on their concentration, the cell system, the type or stage of the pathological process(85).

6. Black pepper
Black pepper is a flowering vine in the family Piperaceae, used as a spice and seasoning.

Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1, and DU-145 prostate cancer cells in a dose-dependent manner.

And, In caspase activation in LNCaP and PC-3 cells(86) and β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oil of black pepper(Piper nigrum L.) not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and nutrient–hormonal signaling network) pathway signaling cascade but also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21(87).

7. Green tea
Green tea contains more amount of antioxidants than any drinks or foods with the same volume as the leaves of Camellia sinensis, has undergone minimal oxidation during processing, and originated from China.

Green tea catechins (GTCs), a potent chemical constituent containing (-)-epigallocathechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment of pre-prostate cancer men, reduced lower urinary tract symptoms, improved coexistent benign prostate hyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).

In the green tea polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti-PCa (89) effect by modulation of signaling pathways.

Also, a combination of quercetin and green tea showed a significant increase in inhibition of proliferation, androgen receptor, phosphatidylinositol 3-kinase/Akt signaling(tumorigenesis in early stage), and stimulation of apoptosis(90).

In short, Green tea, a potent anti-prostate cancer with activities of heritable alterations of gene expression and chromatin organization without changes in DNA sequence-induced multistep processes of carcinogenesis(91) may be considered as a natural treatment in various types of cancer.

8. Organic fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of some time.

In Japan, the incidence of prostate cancer in aging men is low compared to the West.

This result may be due to the traditional Japanese diet in the exertion of prostate cancer protective effects

In fact, a Traditional Japanese diet rich in soybean products and fish is associated with reduced prostate cancer risk(92).

In China, a lower risk of prostate cancer is associated with the consumption of soy foods and isoflavones found abundantly in fermented soybean products(93).

Unfortunately, the epidemiological data, linking fermented soybean products to reduced risk of prostate cancer are inconsistent including miso.

Conclusion
The prevalence and widespread of prostate cancer may be diet, demographic, and lifestyle-related disease(94)(95)(96).

Eating healthy, with plenty of vegetables and fruits has always been considered a preventive approach. "Let foods be your medicine and let medicine be your foods" by Greek physician Hippocrates (460-377 BC).


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.




References
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery by Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT. (PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM. (PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH. (PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrate inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR. (PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen-Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS. (PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green tea polyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. (PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW. (PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL. (PubMed)
(95) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)

#GreenTea Intake Daily and Regularly Is Associated with Anti-#Depression Activities, According to Studies

Kyle J. Norton

Herbal plants have formed a fundamental source for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness, affecting the way you eat, sleep, and the way you feel about yourself.

Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.

According to general belief, people who suffer from depression may experience some mental and physical symptoms, observed by screen assay for depression in clinical settings.

The most common mental symptoms are feeling sad without reason and guilty, emotionally out of control, trouble concentrating or remembering, lack of motivation, having negative thoughts,...., particularly, loss of interest in usually pleasurable activities.

And most common physical symptoms include lack of energy or fatigue, difficulty performing daily activities, changes in sexual desire, and appetite,.... particularly, in a change of sleep pattern or difficulty sleeping.

In concern to the causes of depression, researchers do not know why some people are more susceptible to the syndrome while some don't. However, depression may associate with a lot of different factors that affect our mental health.

According to the mapping risk factors for depression across the lifespan, the development of depression may involve a complex interplay of environmental and genetic risk factors including widowhood, physical abuse during childhood, obesity, having 4-5 metabolic risk factors, sexual dysfunction, job strain and with no consistent evidence for the causal effects of obesity, smoking, and alcohol consumption(4).

If you are experiencing some of the above symptoms, you may be at the early onset of depression. Please make that you see the related field specialist immediately.

If you are taking conventional antidepressants, such as sertraline (Zoloft), fluoxetine (Prozac, Sarafem) citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle), fluvoxamine (Luvox), please make sure you know the adverse effects such as increased appetite, weight gain, loss of sexual desire, fatigue, drowsiness, insomnia. dry mouth, blurred vision, constipation,.....

Green tea may have a profound effect in reduced risk and treatment of depression, some scientists suggested


Green tea, a precious drink processes a number of health benefits, known to almost everyone in Asia and the Western world.

In vivo, the application of green tea(GT) and GABA green tea (GGT) expressed a protective activity against post-stroke depression (PSD), a common consequence of stroke, according to a joint study led by Pavia University.

And, in a mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......

Also, according to a cross-sectional study of consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, conducted by the joint venture lead by the Fukuoka Women's University, green tea consumption is associated to reduce symptoms of depression, depending to the amount of intake.

Compared amount intake, participants who consumed ≥4 cups of green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those who consumed less than 1 cup/d.

The multiple-adjusted odds for depressive symptoms comparing the highest with the lowest quartile of caffeine consumption was 0·57.

These results suggested that green tea consumption has a linear effect correlated to the number of cup intake per day without mentioning the effects of the maximum number of cups that patients can take.

Dr. Pham NM, the lead author in the study said, "Higher consumption of green tea, coffee, and caffeine may confer protection against depression".

Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease in the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.

Taking together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily.

However, oral administration of large amounts daily should be taken with care, particularly, in people with yin constituents.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T 1. (PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M 1. (PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
(4) Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies by Köhler CA1, Evangelou E2, Stubbs B3, Solmi M4, Veronese N5, Belbasis L6, Bortolato B7, Melo MCA1, Coelho CA1, Fernandes BS8, Olfson M9, Ioannidis JPA10, Carvalho AF. (PubMed)

The Anti #BreastCancer Fruits, According to Studies

Kyle J. Norton

The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer is widespread in women in Southeast Asia as a result of over 2 decades of economic prosperity caused by an unhealthy diet is a major concern.

The findings for effective treatments are ongoing with some successes, but to discover effective prevention and treatment with little or no side effects has proven difficult.

According to statistics, the risk of getting invasive breast cancer during the lifetime of women is 1/8.

A healthy diet with plenty of vegetables and fruits(1)(2)(3) with a change of lifestyle(4)(5)(6) may be the only choice for women in reducing the risk of the diseases.


1. Blueberry
Blueberry is a flowering plant, belongings to the family Eriaceae, native to Northern America.

Triple-negative breast cancer TNBC, cancer does not express the genes for estrogen receptor (ER), progesterone receptor(PR), and HER2(gene) affecting approximately 15% of all cancer cases.

Female MDA-MB-231 tumor-bearing mice fed with a high-fat diet with 5% whole blueberry powder (BB), inhibited TNBC and TNBC-related metastasis by reducing inflammation via specific cytokine-driven pathways through the immune response in reduced tumor growth and metastasis(40).

In 17β-estradiol-mediated mammary tumorigenesis, a 5% blueberry diet, decreased tumor volume and multiplicity significantly, by down-regulation of CYP 1A1(enzymes, able to activate compounds with carcinogenic properties) and ER-α (a receptor activated by the sex hormone estrogen)genes expression and also favorable modulation of microRNA (mir-18a and mir-34c) levels in gene regulation(41).

Other chemical constituents such as anthocyanin and anthocyanin-pyruvic acid adduct extract of blueberry restricted cancer cell proliferation by acting as cell anti-invasive factors and chemoinhibitors(42).

2. Avocado
Avocados, the green-skinned, pear-shaped fruit that ripens after harvesting are a commercially valuable fruit cultivated in tropical climates throughout the world, native to the Caribbean, Mexico, South America, and Central America, belongings to the flowering plant family Lauraceous.

Avocado-produced toxin persin may contain a positive anti-breast cancer effect(43).

Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).

Application of persin in animal models, selectively induced G2-M cell cycle arrest and cell death through the caspase-dependent pathway(44).


3. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Rosaceae, grown all over the world with suitable climates for commercial profits and health benefits.

Methanolic extract of strawberry (MESB) fruits induced cytotoxicity in cancer cells, irrespective of origin, in a concentration- and time-dependent manner, in the testing against leukemia (CEM) and breast cancer (T47D) cell lines through induction of intrinsic pathway of apoptosis by activating p73 (a tumor suppressor) in breast cancer cells, when tumor suppressor gene p53 was mutated(46).

Polyphenols, a major chemical component found in strawberries, exhibited cytotoxic with doses of approximately 50 microg/ml, inducing a 50% reduction in cell survival in both the normal and the tumor lines, including (MCF-7) breast cancer cell lines(47).

In another study, freeze-dried fruits of two strawberry cultivars ethanol extract strongly inhibited CaSki and SiHa cervical cancer cell lines and MCF-7 and T47-D breast cancer cell lines(48).

4. Pomegranate
The pomegranate is a fruit-bearing small tree, genus Punica, belongings to the family Lythraceae, native to Iran, and cultivated in Asia since ancient times.

Pomegranate extracts and genistein exerted anti-cancer effects in the inhibition of cell proliferation and induction of apoptosis in human breast cancer cells(MCF-7) in doses and time depending manner(49) by downregulated HR genes (a ubiquitous cellular pathway that mediates the transfer of genetic information) and increased expression of microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (regulation of gene expression)(50).

Pomegranate fruit extracts (PFEs), on dose-dependent, inhibited NF-kB-dependent reporter gene responses associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression as these genes are associated with tumor cell invasion and metastasis(51).

6. Grapes
Resveratrol, a polyphenolic compound known as a good chemopreventive agent for inhibiting carcinogenesis processes that target the regulators of cell function and DNA replication, found abundantly in grapes, berries, and peanuts is associated with a reduced risk of breast cancer.

HS-1793, a synthetic version of the compound of resveratrol-induced G2/M(DNA damage checkpoint) arrest in the cell cycle progression through induction of p53(tumor suppressor gene)-dependent apoptosis in MCF-7 cells(52).

Catechin (RQC), a polyphenol, was effective in ameliorating mammary tumor growth and metastasis, by reducing Akt (multiple cellular process activity, induced the activation of AMPK(cellular energy)), and inhibited mTOR(mediate cellular responses) signaling in breast cancer cells(53).

In Her-2 breast cancer, fox grape seed extract increased the expression of Bax(an apoptosis promoter) and AIF(Apoptosis-inducing factor), and decreased total PARP(cellular processes) expression, leading to significant downregulation of Her-2 in MCF-7 cells(54).

7. Pineapple
Pineapple is a species of Ananas Comos, belongings to the family Bromeliaceae and native to southern Brazil and Paraguay, cultivated for commercial uses.

Pineapple is rich in vitamins and minerals and digesting enzyme bromelin seems to help digestion after a high protein meal.

Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).

Bromelain, a major chemical constituent exerted anti-metastasis against breast cancer by upregulating the function of c-Jun N-terminal kinase in cell proliferation, differentiation, survival and migration, and p38 kinase to cause programmed cell death(56).

In GI-101A breast cancer cells, bromelain induced cell death via activation of the apoptosis mechanism, in increased dose-dependent by promoting apoptosis and cytokine processing of caspase-9 and caspase-3 coinciding with the elevation of serum CK18 levels(56).

In the brMDA-MB-231 mammary carcinoma, oral administration of bromelain increased the reduced bMAK- and MAK-cell activity in cell cycle regulation from 7.8% to 54% (bMAK-cell activity) and from 16% to 47% (MAK-cell activity by stimulating the deficient monocytic cellular cytotoxicity of the mammary tumor(57).

8. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, which originated in Central Asia.

In estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 breast cancer cell lines, apple phytochemical extracts significantly inhibited cell proliferation in a dose-dependent manner and cell cycle modulation(58).

In breast carcinoma, Mcf-7 and Mcf-7, Her18 cells, peels of apple were effective in antiproliferation accompanied by a G0-G1 phase arrest in cell cycle through activated tumor suppressor protein that suppressed the regulation of cell invasion, metastasis, and angiogenesis(59).

A study of apple extracts and quercetin 3-beta-d-glucoside combination also showed to possess a synergistic effect in MCF-7 cell proliferation(60).

9. Orange
Orange is a species of Citrus Sinensis, belongings to the family Rutaceae and native to Southeast Asia.

Polymethoxyflavones (PMFs), a chemical compound found in sweet orange (Citrus sinensis L.) peel, induced Ca(2+)-mediated apoptosis in human breast cancer cells through proapoptotic activity(61).

D-limonene, another compound in orange peel oil, in rodent studies, also exhibited chemotherapeutic activity against mammary cells, through the induction of tumor cell apoptosis, tumor redifferentiation, and/or suppression of key proteins of cell growth-regulating (62).


Taken Together, vegetables(7)(8) and fruits(9)(10) or their chemical compounds may process a huge effect in reducing the risk, progression, and treatment of breast cancer through induced apoptosis by blocking the energy sources of the pathways, influencing the signal pathways of cell proliferation or suppressing the promoted cancers genes.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC. (PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA. (PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME. (PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)(43) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ. (PubMed)
(44) A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells by Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, Macleod JK, Liaw TY, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK, Sutherland RL. (PubMed)
(45) Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism by Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ. (PubMed)
(46) Extracts of strawberry fruits induce the intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(47) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed) (48) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells, by Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL. (PubMed)
(49) Anticancer activities of pomegranate extracts and genistein in human breast cancer cells by Jeune MA, Kumi-Diaka J, Brown J.(PubMed)
(50) Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double-strand breaks by Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.(PubMed)
(51) Pomegranate fruit extract impairs invasion and motility in human breast cancer by Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD. (PubMed)
(52) The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women by Monroe KR, Stanczyk FZ, Besinque KH, Pike MC. (PubMed)
(53) HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells by Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, Yoon JH, Suh H, Jeong TC, Chung HY, Kim ND. (PubMed)
(54) Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer by Castillo-Pichardo L, Dharmawardhane SF. (PubMed)
(55) Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- of Vitis labrusca extract by Scola G, Fernandes Correia Laurino CC, Menin E, Salvador M.(PubMed)
(56) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A.(PubMed)
(57) Effects of oral bromelain administration on the impaired immune cytotoxicity of mononuclear cells from mammary tumor patients by Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR. (PubMed)
(58) Apple phytochemical extracts inhibit the proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation by Sun J, Liu RH.(PubMed)
(59) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(60) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancercells in vitro by Yang J, Liu RH.(PubMed)
(61) Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(PubMed)
(62) Monoterpenes in breast cancer chemoprevention by Crowell PL. (PubMed)

The Detoxification #WholeFoods

Kyle J. Norton

American diet contains high saturated, trans fat, and other harmful substances such as sugar, caffeine, pesticides, addictive substances, and less in fruits and vegetables.
These types of harmful substances are toxic.

Some researchers suggested that diet and exposure to environmental toxins can damage the function of the mitochondria in cells in converting food to energy, affecting the organ's function in the protection of the body in all aspects.

The damage to mitochondria can increase the overexpression of free radicals in the induction of cytotoxicity to cells and tissue through a negative chain reaction

Foods that can detoxify our body against cytotoxicity include
1. Spinach
Spinach contains
* High levels of vitamins A, E, and C, the free radical scavengers with function in reduced oxidative stress by improving the production of antioxidant enzymes(1)(2).

* Numbers of trace minerals act as an antioxidant in inhibited ROS species such as iron, potassium, magnesium, zinc, and calcium(2). The presences of trace minerals in equal amount are vital for a healthy heart.

* Antioxidants, such as lutein and beta-carotene(3) strengthen our immune system and fight against the forming of free radicals.

People with kidney disease should not eat spinach, because it is rich with oxalates.

Without drinking a lot of water or juice, the intake of the veggie will increase the risk of kidney stone formation.

2. Broccoli
Broccoli is high in vitamin C(1), an antioxidant that has the property in reduced the risk of inflammation and prevented forming of free radicals caused by toxins in our body.


The study shows that some of the chemicals such as indole 3, selenium, and diindolymethane have anti-cancer properties and help to prevent and repair DNA-damaging cells(4)(9).

3. Garlic
Garlic is a supernatural food. Besides having a proven record in preventing heart diseases, lower cholesterol levels, and elevated blood pressure(5), it also contains high amounts of allicin, an antibody that helps to reduce inflammation and fight off degeneration caused by viruses, bacteria, strengthening our immune system(6) and forming of free radicals(7).

The sulfur element helps to rejuvenate our body by increasing the function of the liver in removing toxins(7).

4. Blackberry
Besides having a large amount of vitamins C and E(1) blackberry also contains anthocyanins and ellagic acid that work together in preventing inflammation, improving mental performance as well as strengthening the immune system(8). Its antioxidant function also removes the accumulation of heavy metal toxins in our bodies (9).

5. Mellon
Mellon contains high amounts of antioxidant enzyme(9), minerals(2), and the powerful antioxidant chlorophyll(9), which is rich in antioxidants, vital minerals such as magnesium, iron, potassium, calcium, and essential fatty acids(2) with functions in removed heavy metals accumulated in the brain and toxins in our kidney(10)

6. Green tea
Green tea balances the PH level(11) in the blood, it also contains polyphenolic catechins, a powerful antioxidant that strengthens the immune system(9), fights against free radicals building up, and detoxes our body through urinary secretion(9)(12).

7. Cooked Tomato
Tomatoes contain high amounts of alpha and beta-carotene that help to strengthen the body's immune system to fight off inflammation from bacteria and viruses causing many types of chronic diseases(3).


The vegetable also contains lycopene(13), a powerful antioxidant that prevents the forming of free radicals caused by the accumulation of toxic substances in the body when working together with lutein(3). Be sure that the veggie is well cooked(14).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Vitamin E and C supplementation reduce oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats by Michael J. Ryan,1 Holly J. Dudash,1 Megan Docherty,1 Kenneth B. Geronilla,1,2 Brent A. Baker,2G. Gregory Haff,1 Robert G. Cutlip,2 and Stephen E. Alway(PubMed)
(2) Vitamins and minerals functioning as antioxidants with supplementation considerations Lee R. McDowell1, Nancy Wilkinson, Rachel Madison and Tara Felix Department of Animal Sciences University of Florida
(3) Potential Role of Carotenoids as Antioxidants in Human Health and Disease by Joanna Fiedor* and Květoslava Burda(PubMed)
(4) Nutritional Epigenetic Regulators in the Field of Cancer by Michael Schnekenburger1, Marc Diederich2, in Epigenetic Cancer Therapy, 2015
(5) Garlic and Cardiovascular Disease: A Critical Review Khalid Rahman Gordon M. Lowe, The Journal of Nutrition, Volume 136, Issue 3, 1 March 2006, Pages 736S–740S,https://doi.org/10.1093/jn/136.3.736S
(6) The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention by Georgia Schäfer1 and Catherine H. Kaschula(PubMed)
(7) The mode of action of allicin: trapping of radicals and interaction with thiol-containing proteins by Rabinkov A1, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L(PubMed)
(8) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days by Stoner GD1, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun X(PubMed)
(9) Free radicals, antioxidants, and functional foods: Impact on human health by. Lobo, A. Patil, A. Phatak, and N. Chandra(PubMed)
(10) Toxicity, mechanism and health effects of some heavy metals by Monisha Jaishankar, Tenzin Tseten, Naresh Anbalagan, Blessy B. Mathew, and Krishnamurthy N. Beeregowda(PubMed)
(11) Evaluation of the pH and titratable acidity of teas commercially available in Brazilian market ORIGINAL | ORIGINAL Avaliação do pH e titrabilidade ácida de chás comercialmente disponíveis no mercado brasileiro
(12) 5 Kidney Cleansing Drinksby Dr. Group by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM
(13) Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview by Jalil Pirayesh Islamian, Ph.D.* and Habib Mehrali, M.Sc(PubMed)
(14) Cooking Tomatoes Boosts Disease-Fighting Power, Date: April 23, 2002 (by Cornell University)

The #AllergicReactions #Severity and Degeneration Scales

Kyle J. Norton

Allergy is the overreaction of the immune system to harmless substances after entering our body affecting 1 in every 3 people.

Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result of
overproduction of Immunoglobulin E (IgE), a class of allergic antibodies by the immune system against a harmless substance with an aim to mediate the release of histamine and other mediators from mast cells and basophils, that lead to an allergic reaction, including mucus secretion, sneezing, itching, etc.

Food allergy is a result of the overproduction of the antibody Immunoglobulin E (IgE) of the immune system in responding to harmless ingredients in the foods such as peanuts, shrimp, crayfish, lobster, walnuts, peanuts, soy, legume, etc., after eating.

Food allergy is severe food intolerance, in some cases, it may be fatal or hospitalized.

A. Food allergy can be classified into 2 types, depending on the length of the reaction of the immune system
1. Fixed food allergy
Fixed food allergy is defined as symptoms of allergy that appeared immediately as soon as the allergic food is eaten.

2. Marked (Cyclic) allergies
This type of allergic symptom may take longer to take effect, usually, an hour or days after the allergic food is eaten. Coiled foods allergy affects 90% of the patient in all cases.

B. How to determine the severity of the allergic effects
Depending on the allergy-stimulating effect, some researchers suggested scaling the severity from 1 to 4 and followed by a degeneration scale, but from -1 to -4
1. The severity scale from +1 to +4
+1. The first level of stimulation
If there are no symptoms at all or If the patient is alert and functioning morally after allergic is eaten
+2. The second level of stimulation
The patient has become irritable, hyperactive, tense, thirsty, etc. after suspected allergic food is eaten
+3. The third level of stimulation
The patient has become hypomanic, aggressive, apprehensive, etc.
+4. The fourth level of stimulation
The patient has become a mania, agitation, overexcitement, etc.

Other severity scales may also be used for all allergies, such as 1-6. 6 being the most severe. I think 0 is nonallergic.

2. Degeneration scale from -1 to -4
-1. If a patient is experiencing symptoms of the reaction of a runny nose, hive, diarrhea, etc.
-2. If a patient is experiencing symptoms of the reaction of tiredness, fatigue, swelling, etc.
-3. If a patient is experiencing symptoms of the reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experiencing symptoms of the reaction of severe depression, paranoia, etc.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) How Far Can We Control the Severity of Food Allergic Reactions by Controlling Exposure to Allergenic Foods? ILSI Europe Workshop, 16 September 2016, Brussels
(2) Allergy DiagnosisReference Guide

#Phytochemical #Isothiocyanates Improve the Levels of Host's #AntioxiantEnzymes Against the Risk of Cancer, Researchers Say

Kyle J. Norton

Dithiolthione, a phytochemical found abundantly in cruciferous vegetables may be the next target for the development of chemo medicine for the treatment of cancer without inducing any side effects, some studies suggested.

Cancers are a class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.

At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluid circulation.

The causes of cancer are unknown. Epidemiological studies suggested that depending on the type of cancer, the most common risk factors are aging, tobacco, sun exposure, radiation exposure, chemicals toxins, viruses and bacteria, change of hormones, family history, excessive alcohol drinking, poor diet, lack of physical activity and overweight or obesity.

However, most people with some of the above risk factors have never developed cancer.

Genetic preposition and acquired genetic mutation are the most risk factors that can precisely predict the percentage of prevalent risk of the onset of the disease.

Mutation of gene TP53 and PTEN. which produces a protein that suppresses the growth of tumors, genetic mutation of BRCA1 and BRCA2 genes is associated with a higher risk of cancer.

In acquiring genetic mutation, some researchers suggested that the result of errors in the cell cycle division caused by long-term exposure to carcinogenic substances such as tobacco smoke and occupations that are required to chemical exposure that also damage the cells' DNA are also some prevalent factors associated to the increased risk of cancers.

The US National Library of Medine wrote "For example, certain mutations in the BRCA1 or BRCA2 genes greatly increase a person's risk of developing breast cancer and ovarian cancer. Variations in other genes, such as BARD1 and BRIP1, also increase breast cancer risk, but the contribution of these genetic changes to a person's overall risk appears to be much smaller".


Futhermore, on the other front of acquired genetic mutation, Dr. Michael R. Stratton, the lead author in the study "The cancer genome" said, "The cancer cell may have acquired, from exogenous sources, completely new DNA sequences, notably those of viruses such as human papillomavirus, Epstein Barr virus, hepatitis B virus, human T lymphotropic virus 1 and human herpesvirus 8, each of which is known to contribute to the genesis of one or more type of cancer".


Some researchers proposed that cancer may be the result of weakened immunity, Dr. Louise M.E. Janssen, the lead scientist in the study "The immune system in cancer metastasis: friend or foe?" said, "The primary tumor induces an immune response, which may not be sufficient to destroy the primary tumor, but prevents the growth of a secondary tumor or metastases. Since that time, many different immune cells have been shown to play a role in both inhibiting and promoting metastatic disease".


Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

In the concerns of chemo drugs side effects in the treatment of invasive cancers, researchers in the cancer team at the Shanghai Jiaotong University School of Medicine conducted an experiment to test the association between urinary levels of isothiocyanates (ITCs) and the risk of pancreatic cancer in urban Shanghai.

The case-control study has been conducted in urban Shanghai from December 2006 to December 2008) through a newly established "instant case reporting" system.


Intake of cruciferous vegetable intake and ITC consumption, urinary ITC levels (median (P25, P75)) were 95.0 (66.9, 135.8) g/d, 11.0 (7.1, 16.0) µmol/d, 0.95 (0.12, 2.92) µmol/g Cr respectively in treatment cases, all lower than those of controls, separately 107.4 (80.1, 154.1) g/d, 12.3 (8.0, 18.0) µmol/d, 1.78 (0.53, 5.28) µmol/g Cr with statistically significant difference of 3.75.

The urinary levels of ITCs in all cases were found to have a correlation with cruciferous vegetable consumption and dietary ITC exposure.

Further analysis suggested that there is an inverse association between urinary ITCs and the risk of pancreatic cancer after adjusting for possible confounding factors such as age, sex, history of diabetes, and pancreatitis.

Dr. the lead author said, " High levels of cruciferous vegetables or ITC consumption were associated with a reduced risk of pancreatic cancer (all P trend <0.05)".

Moreover, in the study to test the combination of Thiazolo and isothiocyanates antiproliferative activity in a panel of 8 cancer cell lines, including lung (NCI-H322 and A549), epidermal (A431), glioblastoma (T98G), pancreatic (MIAPaCa-2), prostate (PC-3), human leukemia (HL-60) and breast (T47D) cells, researchers found that

* The combination injection showed antiproliferative activity in the lung (NCI-H322 and A549), epidermal (A431), and glioblastoma (T98G) cancer cell lines with IC50 values of 7.1, 1.4, 3.1, and 3.4 μM, respectively.

* The application compound showed the induction of apoptosis in A549 cells at 10 μM, as indicated by the increase in the sub-G1 population.

* The compounds also induced apoptosis in HL-60 cells at 20 μM. The effect of compound 4a on mitochondrial potential loss in HL-60 cells. was also studied.ct

These results suggested that Thiazolo under the influence of isothiocyanates demonstrated potency in the inhibition of all cancer cell lines in a concentration and dose-dependent manner without inducing any side effects.

More importantly, Dr.de Figueiredo SM, the lead scientist at the Campus Morro do Cruzeiro in the study "The anti-oxidant properties of isothiocyanates: a review" revealed that ITCs induce Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibit antitumor activity at post-initiation phase.

Additionally, the lead researcher also suggested that ITCs inhibit the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, and human ovarian cancer cells, and have anti-inflammatory properties in the treatment of human T-cell leukemia cells probably through improving antioxidant status.


Taken altogether, Phytochemical Isothiocyanates found abundantly in cruciferous vegetables may be considered a bioactive functional ingredient for the prevention and treatment of cancers, depending on the large sample size and multi-center in the human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [A case-control study on the association between urinary levels of isothiocyanates and the risk of pancreatic cancer].[Article in Chinese] by Wang J1, Han L, Zhang W, Wang J, Ni Q, Shen M, Gao Y2.(PubMed)
(2) Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines by Singh B1, Guru SK, Kour S, Jain SK, Sharma R, Sharma PR, Singh SK, Bhushan S, Bharate SB, Vishwakarma RA. (PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(4) The immune system in cancer metastasis: friend or foe? by Janssen LME1, Ramsay EE2, Logsdon CD2, Overwijk WW. (PubMed)

#Herbal #ChasteTreeBerry Dried Ripe Fruit Extract Exhibits Cytotoxicity in Cancers by Decreasing te #Cancer's #AntioxidantEnzymes

Kyle J. Norton

Chaste tree berries may have a potential effect in reducing the risk and treatment of cancers, some studies proposed.

Cancer is a class of medical and chronic disease characterized by irregular cell growth, that starts on the cells on the surface of the inner lining of the organ tissue.

At the later stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue through DNA alternation via fluid and blood circulation.

The exact causes of cancer are unknown. As of today, researchers do not know why people with the same health and family history, are susceptible to the onset of the disease while others do not.

According to the statistic provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with some forms of cancer at some point during their lifetimes.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, causing 1,790 death.

Epidemiologically, depending on the primary onset of the disease, the most common risk factors of cancer are aging, tobacco, sun exposure, radiation exposure, chemicals, and toxic substances, certain hormones therapy, and family history,

However, excessive alcohol, poor diet, lack of physical activity, or being overweight also are considered some major acquired risks of cancer.


Dr. Karen Basen-Engquis, the lead author on the concerns of obesity in the risk of cancer wrote, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%.".

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,

The queen herb has been used in herbal medicine for thousands of years as an anaphrodisiac herb. It is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time.

There was a report that chaste tree berry stems and leaves were used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria.

In the findings of a natural extract that proceeds anti-cancer potency, researchers launched an investigation to examine the anticancer extract preparation ethanol from dried ripened Vitex agnus-castus fruits growing in Israel (Vitex extract) against human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

In the cell cultures, application of different concentrations of Vitex extract after culture for 24 h (logarithmic growth phase) or 72 h (stationary growth phase), exerted a significant cytotoxic activity against all cell lines in logarithmic growth-phase cells, compared to stationary growth-phase cells.

DNA fragmentation, an indication of cancer cells undergoing apoptosis was seen in SKOV-3, KATO-III, COLO 201, and Lu-134-A-H cells.

Furthermore, Vitex extract-treated KATO-III cells also inhibited the expression of heme oxygenase-1 and the active forms of caspases-3, -8, and -9 which play a critical role in the protection of the cancer cell against cytotoxicity.

Dr. Ohyama K, the lead author, said, "(The) cytotoxic activity of Vitex extract may be attributed to the effect on cell growth, that cell death occurs through apoptosis, and that this apoptotic cell death may be attributed to increased intracellular oxidation by Vitex extract treatment".

In a human gastric signet ring carcinoma cell line, KATO-III. further analysis also suggested that the application of ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) decreases the antioxidant enzyme produced by the cancer cells without affecting the levels of the level of GSSG, another indication of oxidative stress increased in the cancer cells.


The result indicated that, Vitex-induced apoptosis through intracellular oxidative stress and mitochondrial membrane damage by decreasing the antioxidant defense of the cancer cell lines.

Taken altogether, Chaste Tree Berries may be considered a functional food and adjunct therapy for the prevention and treatment of cancers, depending on the result of the large and multi-center studies in human consumption of the herb during the course of diseases.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)