Kyle J. Norton
Osteoporosis is a medical condition characterized by the loss of bone density.
In other words, the bone disease is a result of overexpression of bone loss due to bone resorption compared to bone made by the body, leading to risk bone fracture and breaking.
In a severe case, the bones of patients with osteoporosis may become so weak, they can break from a fall or even from sneezing or minor bumps.
Microscopy, healthy bone processed a high density (fewer spaces and small holes in the honeycomb) compared to low density ( large spaces and holes in a honeycomb) in patients with osteoporosis.
In the US, due to the widespread osteoporosis in the elderly, the disease has become a concern of the scientific community. Believe it or not, according to the statistics, osteoporosis is responsible for two million broken bones and $19 billion in related costs every year.
As the condition continues to worsen, by 2025, osteoporosis will be responsible for approximately three million fractures and $25.3 billion in costs annually.
According to the statistics, in Canada, osteoporosis affects approximately 1.4 million Canadians, mainly in postmenopausal women and the elderly.
Additionally, 1 in 4 women and more than 1 in 8 men over the age of 50 years, with 1 in 4 men and women are having evidence of a vertebral fracture.
Out of many risk factors associated with the onset of osteoporosis, some researchers suggested that the disease may be correlated to the promotion of Western diet over the past few decades.
Dr. Seon-Joo Park, the lead scientist wrote, "(In the comparison of ) "Three major dietary patterns,... using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread).".
And, "..., western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of osteoporosis, researchers evaluated the efficacy, in terms of changes in bone density, and safety of an oral formulation based on turmeric phytosome (Meriva®), in subjects suffering from low bone density.
The study included a total of 57 otherwise healthy subjects with low bone density who freely decided to follow either standard management (SM) to control low bone density (control group=28) or SM associated with a curcumin-based oral supplementation (supplement group=29).
Meriva®-supplemented group remarkably improved in the bone density of the heel measured by the Sahara densitometer accompanied by a significant decrease of ultrasounds transmission values at week 12 (-18.4%) and at week 24 (-21.0%), compared with baseline.
Furthermore, Meriva®-supplemented group also improved the bone densities of the small finger and upper jaw with no adverse effects.
Based on the results researchers said, "This preliminary study suggests that a curcumin-based supplementation in combination with an appropriate lifestyle could be beneficial in the prevention and management of osteopenia".
In order to know more information about turmeric anti-osteoporosis activity, researchers examined the effects of curcumin on oxidative stress-induced osteoblast apoptosis.
The study included an osteoblastic cell line (Saos-2) exposed to various concentrations of H2O2 with or without curcumin treatment.
Injection of curcumin protected the viability of Saos-2 cells against the exposure to H2O2 and attenuated H2O2-induced apoptosis.
Furthermore, curcumin also improved the cellular function by preserving the mitochondrial redox potential, decreasing the mitochondrial oxidative status, through its antioxidants activity.
Moreover, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK3β) that have been found to induced bone loss in low levels.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study by Riva A1, Togni S, Giacomelli L, Franceschi F, Eggenhoffner R, Feragalli B, Belcaro G, Cacchio M, Shu H, Dugall M. (PubMed)
(2) Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling by Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S. (PubMed)
(3) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PMC)
Wednesday, 28 June 2023
#Phytochemical Tetrachlorodibenzo-p-Dioxin (TCDD) and 3,3'-#Diindolylmethane (DIM) Inhibit #ProstateCancer Cells Proliferation and Invasion
Kyle J. Norton
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.
The disease often is discovered during the rectum examination annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, and frequent and urge urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistics, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cell by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information of DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer protective food bioactives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.
The disease often is discovered during the rectum examination annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, and frequent and urge urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistics, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cell by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information of DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer protective food bioactives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
#Herbal #Ginger Protects the Neurons Against the Risk of #Parkinson's disease(PD)Through its Antioxidant Activity
Kyle J. Norton
Parkinson's disease (PD) is a disabling, progressive condition caused by the gradual loss of neuron cells.
In other words, PD is a cognitive deficit associated with the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop and loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
According to the statistics, more than 10 million people worldwide are living with PD. In the US, every year, 60,000 adults are diagnosed with PD. Approximately, over 95% of people diagnosed with PD are over 50 years of age.
PD can be classified into 5 stages, depending on the severity
* Stage 1
In stage 1, symptoms of PD do not interfere with daily activities.
* Stage 2
In stage 2, the symptoms start to get worse over time. Making living alone to carry daily task now may be difficult.
* Stage 3
The symptoms are now interfering with daily activity, including the impairment of dressing and eating.
* Stage 4
The symptoms are severe with limited functioning, Patients in this stage have required the help of others to carry out daily activity.
* Stage 5, the most advanced stage of PD. Around-the-clock care is required for all activities.
The exact causes of PD are unidentified. However, the epidemiological study suggested that age and sex, genetic factors, head trauma, exposure to chemicals, long-term use of certain medications and drugs are some of the prevalent risks of Parkinson disease (PD).
Some researchers suggested lifelong cigarette smoking may have a strong impact on the risk of PD.
Dr. Chaoran Ma, the lead scientist wrote, "Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system".
And, "Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias".
The results strongly suggested that if you smoke, your risk of PD is increased substantially compared to never smoke healthy adults.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers in the concern about Parkinson's disease (PD) associated with the progressive degeneration of dopaminergic neurons in the nigrostriatal system and dopamine (DA) depletion in the striatum, examined the Zingerone and eugenol, essential oils extracted from ginger and cloves, free radical scavenging and antioxidant effects.
Rodents used in the study were induced PD by injected with 6-hydroxydopamine (6-OHDA) intracerebroventricularly.
According to the assays, daily oral administration of eugenol/zingerone and injection of L-DOPA intraperitoneally for 4 weeks following a single 6-OHDA injection did not improve abnormal behaviors induced by L-DOPA treatment.
Where 3-(3,4-Dihydroxyphenyl)-L-alanine (L-DOPA) is the most popular therapeutic medicine for treating PD with adverse effects.
However, injection of zingerone and eugenol alone enhanced the reduction of striatal DA and its metabolites and zingerone decreased the oxidative stress and increased the levels of antioxidants such as glutathione peroxidase and the oxidized L-ascorbate in the striatum.
In other words, compared to the effects of zingerone against PD through its antioxidant activity, pre-treatment with zingerone or eugenol do not prevent 6-OHDA-induced DA depression by preventing lipid peroxidation.
Taken together, ginger may be considered a functional spice for the prevention and treatment of PD, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model by Kabuto H1, Yamanushi TT. (PubMed)
(2) Nicotine from cigarette smoking and diet and Parkinson disease: a review by Chaoran Ma,1 Yesong Liu,2 Samantha Neumann,3 and Xiang Gao. (PMC)
(3) Stages of Parkinson's by Parkinson's Foundation
Parkinson's disease (PD) is a disabling, progressive condition caused by the gradual loss of neuron cells.
In other words, PD is a cognitive deficit associated with the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop and loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
According to the statistics, more than 10 million people worldwide are living with PD. In the US, every year, 60,000 adults are diagnosed with PD. Approximately, over 95% of people diagnosed with PD are over 50 years of age.
PD can be classified into 5 stages, depending on the severity
* Stage 1
In stage 1, symptoms of PD do not interfere with daily activities.
* Stage 2
In stage 2, the symptoms start to get worse over time. Making living alone to carry daily task now may be difficult.
* Stage 3
The symptoms are now interfering with daily activity, including the impairment of dressing and eating.
* Stage 4
The symptoms are severe with limited functioning, Patients in this stage have required the help of others to carry out daily activity.
* Stage 5, the most advanced stage of PD. Around-the-clock care is required for all activities.
The exact causes of PD are unidentified. However, the epidemiological study suggested that age and sex, genetic factors, head trauma, exposure to chemicals, long-term use of certain medications and drugs are some of the prevalent risks of Parkinson disease (PD).
Some researchers suggested lifelong cigarette smoking may have a strong impact on the risk of PD.
Dr. Chaoran Ma, the lead scientist wrote, "Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system".
And, "Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias".
The results strongly suggested that if you smoke, your risk of PD is increased substantially compared to never smoke healthy adults.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers in the concern about Parkinson's disease (PD) associated with the progressive degeneration of dopaminergic neurons in the nigrostriatal system and dopamine (DA) depletion in the striatum, examined the Zingerone and eugenol, essential oils extracted from ginger and cloves, free radical scavenging and antioxidant effects.
Rodents used in the study were induced PD by injected with 6-hydroxydopamine (6-OHDA) intracerebroventricularly.
According to the assays, daily oral administration of eugenol/zingerone and injection of L-DOPA intraperitoneally for 4 weeks following a single 6-OHDA injection did not improve abnormal behaviors induced by L-DOPA treatment.
Where 3-(3,4-Dihydroxyphenyl)-L-alanine (L-DOPA) is the most popular therapeutic medicine for treating PD with adverse effects.
However, injection of zingerone and eugenol alone enhanced the reduction of striatal DA and its metabolites and zingerone decreased the oxidative stress and increased the levels of antioxidants such as glutathione peroxidase and the oxidized L-ascorbate in the striatum.
In other words, compared to the effects of zingerone against PD through its antioxidant activity, pre-treatment with zingerone or eugenol do not prevent 6-OHDA-induced DA depression by preventing lipid peroxidation.
Taken together, ginger may be considered a functional spice for the prevention and treatment of PD, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model by Kabuto H1, Yamanushi TT. (PubMed)
(2) Nicotine from cigarette smoking and diet and Parkinson disease: a review by Chaoran Ma,1 Yesong Liu,2 Samantha Neumann,3 and Xiang Gao. (PMC)
(3) Stages of Parkinson's by Parkinson's Foundation
#Mixture Including #Blueberry, #Bilberry, and Indian #Blackberry Protects the Lung Cells Against the Onset of #NSCLC, Scientists Say
Kyle J. Norton
Lung cancer is a chronic condition characterized by cell growth irregularly and disorderly in the lung tissue.
Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.
At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to secondary metastasis.
According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.
Smoking although is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers' lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.
Some researchers suggested that lung cancer in many incidences is associated with oxidative stress as found in advanced lung cancer patients.
Dr. the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".
And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".
The results clearly suggested that the external sources of dietary antioxidants from the food sources may be helpful in reducing the risk of lung cancer by suppressing the overexpression of free radicals before they can induce oxidative stress.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers on finding a replacement for the treatment of lung cancer with no side effects examined the berries' bioactive compound anthocyanidins and its derivative cyanidin, malvidin, peonidin, petunidin, and delphinidin anticancer effects.
A mixture, including blueberry, bilberry, and Indian blackberry ('Jamun') was selected to test in two aggressive non-small-cell lung cancer cell lines.
Injection of the mixture exerted a higher induction of cell-cycle arrest, apoptosis, and suppression of NSCLC cell invasion and migration compared to individual anthocyanidins.
According to tested assays, the mixture inhibited lung cancer cells apoptosis by decreasing the expression of the genes associated with cell cycle division and cell survival and proliferation.
Futhermore, the mixture also elevated the protein involved in cancer cell death programming.
Interestingly, in vivo, both the mixture of anthocyanidins from bilberry (0.5mg/mouse) and the most potent anthocyanidin, delphinidin (1.5mg/mouse) significantly inhibited the growth of H1299 xenografts in nude mice by 60%.
Dr. Kausar H and colleagues said, in the final report "Our results thus demonstrate the therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis".
In order to reveal more information about bilberry anti-lung cancer activity, researchers assessed the involvement of oxidative stress in lung adenocarcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene and wild-type mice (C57BL6/J origin) administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Where deficiency of 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene was found to associate with the advanced stage of cancer.
On week after induced lung cancer by administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), selected mice were treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in the diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks.
All antioxidant applications demonstrated a strong inhibition against lung adenocarcinogenesis, through modulating the gene expression of gene deficiency such as 8-hydroxyguanine DNA glycosylase 1 (Ogg1) and gene mutation such as Egfr and K-ras.
Taken altogether, bilberry-processed abundantly bioactive compounds me be considered a functional remedy for the prevention and treatment of lung cancer, pending to the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells by Kausar H1, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. (PubMed)
(2) Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice by Igarashi M1, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.(PubMed)
(3) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)
Lung cancer is a chronic condition characterized by cell growth irregularly and disorderly in the lung tissue.
Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.
At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to secondary metastasis.
According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.
Smoking although is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers' lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.
Some researchers suggested that lung cancer in many incidences is associated with oxidative stress as found in advanced lung cancer patients.
Dr. the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".
And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".
The results clearly suggested that the external sources of dietary antioxidants from the food sources may be helpful in reducing the risk of lung cancer by suppressing the overexpression of free radicals before they can induce oxidative stress.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers on finding a replacement for the treatment of lung cancer with no side effects examined the berries' bioactive compound anthocyanidins and its derivative cyanidin, malvidin, peonidin, petunidin, and delphinidin anticancer effects.
A mixture, including blueberry, bilberry, and Indian blackberry ('Jamun') was selected to test in two aggressive non-small-cell lung cancer cell lines.
Injection of the mixture exerted a higher induction of cell-cycle arrest, apoptosis, and suppression of NSCLC cell invasion and migration compared to individual anthocyanidins.
According to tested assays, the mixture inhibited lung cancer cells apoptosis by decreasing the expression of the genes associated with cell cycle division and cell survival and proliferation.
Futhermore, the mixture also elevated the protein involved in cancer cell death programming.
Interestingly, in vivo, both the mixture of anthocyanidins from bilberry (0.5mg/mouse) and the most potent anthocyanidin, delphinidin (1.5mg/mouse) significantly inhibited the growth of H1299 xenografts in nude mice by 60%.
Dr. Kausar H and colleagues said, in the final report "Our results thus demonstrate the therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis".
In order to reveal more information about bilberry anti-lung cancer activity, researchers assessed the involvement of oxidative stress in lung adenocarcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene and wild-type mice (C57BL6/J origin) administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Where deficiency of 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene was found to associate with the advanced stage of cancer.
On week after induced lung cancer by administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), selected mice were treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in the diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks.
All antioxidant applications demonstrated a strong inhibition against lung adenocarcinogenesis, through modulating the gene expression of gene deficiency such as 8-hydroxyguanine DNA glycosylase 1 (Ogg1) and gene mutation such as Egfr and K-ras.
Taken altogether, bilberry-processed abundantly bioactive compounds me be considered a functional remedy for the prevention and treatment of lung cancer, pending to the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells by Kausar H1, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. (PubMed)
(2) Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice by Igarashi M1, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.(PubMed)
(3) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)
#Herbal #ArtichokeLeaf Extract Inhibits Free Radical Expression and Lipid Peroxidation, Researchers Find
Kyle J. Norton
Artichoke may be used as a natural ingredient to inhibit the overexpression of reactive oxygen species (ROS), according to studies.
Reactive oxygen species (ROS) or free radicals are highly reactive chemical species containing oxygen molecules. In other words, free radicals are unstable atoms with an unpaired electron in the outer ring.
Therefore, in order to become stable, free radicals must either donate or steal an electron from other atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.
Believe it or not, free radicals in moderate amounts are needed by our body for cell signaling and activation of several transcriptional factors, apoptosis, immunity, and differentiation. However, overexpression of free radicles can cause damage to protein, lipid, and cell alternation, leading to a number of chronic illnesses, including cancer.
Free radicals are generated as metabolic by-products by biological systems. Environmental stressors (i.e., the air we breathe, UV, ionizing radiations, pollutants, and heavy metals) and xenochemicals are also found to contribute to the great increase in ROS production.
In a healthy individual, the production of free radicals is balanced by the antioxidant enzymes produced by the body.
Some researchers suggested that an unhealthy diet may also induce overexpression of free radicals through a number of mechanisms.
Dr. Vial G, the lead scientist said, "A high-fat diet results in both a decrease in mitochondrial quinone pool and a profound modification in mitochondrial lipid composition" and, "These changes appear to play a key role in the resulting inhibition of fatty acid oxidation and of mitochondrial oxidative-phosphorylation associated with an increased mitochondrial ROS production".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural free radical scavenger evaluated the scavenging capacity against the most physiologically relevant reactive oxygen species (ROS) and reactive nitrogen species (RNS) of 3 artichoke extracts from the leaves.
According to the tested assays, all extracts of artichoke leaves processed a remarkable capacity to scavenge ROS and RNS with IC50 values in a low μg/mL range (3.4-43μg/mL).
In HUVEC cells, preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 microg/mL for 24 h showed the complete inhibition of ROS generation induced by LPS which processes biological effects on hosts infected with Gram-negative bacteria.
Where HUVEC cells are normally used for the study of the function and pathology of endothelial cells derived from the endothelium of veins from the umbilical cord.
Injection of the extracts also inhibited lipid peroxidation in the tested HUVEC cells.
Artichoke also reduced the cell apoptosis caused by free radicals damage by inhibiting the ROS generation and reducing the function of cytochrome c, a component of the electron transport chain in mitochondria in triggering programmed cell death through apoptosis.
Taken altogether, artichoke may be considered a free radical scavenger for the prevention and treatment of diseases associated with oxidative stress, pending the result of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynaracardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS by Pistón M1, Machado I1, Branco CS2, Cesio V3, Heinzen H3, Ribeiro D4, Fernandes E4, Chisté RC5, Freitas M. (PubMed)
(2) The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells by Juzyszyn Z1, Czerny B, Pawlik A, Droździk M. (PubMed)
(3) Effects of a high-fat diet on energy metabolism and ROS production in rat liver by Vial G1, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, Athias A, Galinier A, Casteilla L, Leverve XM. (PubMed)
Artichoke may be used as a natural ingredient to inhibit the overexpression of reactive oxygen species (ROS), according to studies.
Reactive oxygen species (ROS) or free radicals are highly reactive chemical species containing oxygen molecules. In other words, free radicals are unstable atoms with an unpaired electron in the outer ring.
Therefore, in order to become stable, free radicals must either donate or steal an electron from other atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.
Believe it or not, free radicals in moderate amounts are needed by our body for cell signaling and activation of several transcriptional factors, apoptosis, immunity, and differentiation. However, overexpression of free radicles can cause damage to protein, lipid, and cell alternation, leading to a number of chronic illnesses, including cancer.
Free radicals are generated as metabolic by-products by biological systems. Environmental stressors (i.e., the air we breathe, UV, ionizing radiations, pollutants, and heavy metals) and xenochemicals are also found to contribute to the great increase in ROS production.
In a healthy individual, the production of free radicals is balanced by the antioxidant enzymes produced by the body.
Some researchers suggested that an unhealthy diet may also induce overexpression of free radicals through a number of mechanisms.
Dr. Vial G, the lead scientist said, "A high-fat diet results in both a decrease in mitochondrial quinone pool and a profound modification in mitochondrial lipid composition" and, "These changes appear to play a key role in the resulting inhibition of fatty acid oxidation and of mitochondrial oxidative-phosphorylation associated with an increased mitochondrial ROS production".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural free radical scavenger evaluated the scavenging capacity against the most physiologically relevant reactive oxygen species (ROS) and reactive nitrogen species (RNS) of 3 artichoke extracts from the leaves.
According to the tested assays, all extracts of artichoke leaves processed a remarkable capacity to scavenge ROS and RNS with IC50 values in a low μg/mL range (3.4-43μg/mL).
In HUVEC cells, preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 microg/mL for 24 h showed the complete inhibition of ROS generation induced by LPS which processes biological effects on hosts infected with Gram-negative bacteria.
Where HUVEC cells are normally used for the study of the function and pathology of endothelial cells derived from the endothelium of veins from the umbilical cord.
Injection of the extracts also inhibited lipid peroxidation in the tested HUVEC cells.
Artichoke also reduced the cell apoptosis caused by free radicals damage by inhibiting the ROS generation and reducing the function of cytochrome c, a component of the electron transport chain in mitochondria in triggering programmed cell death through apoptosis.
Taken altogether, artichoke may be considered a free radical scavenger for the prevention and treatment of diseases associated with oxidative stress, pending the result of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynaracardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS by Pistón M1, Machado I1, Branco CS2, Cesio V3, Heinzen H3, Ribeiro D4, Fernandes E4, Chisté RC5, Freitas M. (PubMed)
(2) The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells by Juzyszyn Z1, Czerny B, Pawlik A, Droździk M. (PubMed)
(3) Effects of a high-fat diet on energy metabolism and ROS production in rat liver by Vial G1, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, Athias A, Galinier A, Casteilla L, Leverve XM. (PubMed)
#Cinigrinphytosome Complex Exerts a Significantly and Greater WoundHealing Effect Compared to #Sinigrin Alone, Researchers Find
Kyle J. Norton
Wound healing is a natural process of the immune system response to protect our body against harmful pathogenic invasion.
After receiving the message from the neurons in the brain, the immune first line of defense including the macrophages stimulates the blood palettes to the site of infection to cover the injury and production of pro-inflammatory cytokines to kill off the stimuli and pathogens which try to enter the body through the wound.
Some anti-inflammatory cytokines under normal conditions also switch to pro-inflammatory cytokines depending on the severity of the injury.
In some cases, overproduction of pro-inflammatory cytokines can cause damage or death of the nearby cells, leading to the formation of irreversible scars, such as hepatitis infection.
Even worse, if the immune system can not kill off all pathogens in the acute phase of infection, it will compromise the new change, leading to chronic low-grade inflammation.
Bacterial pathogens often cause infection in specific areas of the body by overgrowth of the numbers of bacteria in the site, including the gut.
According to epidemiological studies, some bacteria are opportunistic pathogens, and people with a weakened immune system are particularly prone to their invasion.
Dr. Dennis W. Metzger, the lead scientist wrote, " While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections".
The results strongly indicated the increased risk of bacterial infection in people with a weakened immune system.
Researchers on finding a natural compound for speeding up wound healing explored on wound healing effect of sinigrin on HaCaT cells.
In the phytosome with sinigrin with an average particle size of 153 ± 39 nm, the zeta potential of 10.09 ± 0.98 mV and complex efficiency of 69.5 ± 5%.
The formulated sinigrin-phytosome complex significantly exhibited a greater wound-healing effect compared to the use of sinigrin alone.
Compared to only 71% of wounds closer to sinigrin after 42 hours, the phytosome complex completely healed the wound.
At a lower concentration of 0.07 mg/mL, the sinigrin–phytosome complex displayed 79%, whilst sinigrin showed only 50% of wound closure.
At the higher concentration of 0.14 mg/mL the sinigrin–phytosome complex completely cured the wound (100%), compared to only 71% wound healing of sinigrin.
Furthermore, The sinigrin-phytosome complex displayed minimal toxicity towards HaCaT cells.
Injection of the complex also exerted a strong effect on A-375, a human melanoma cell line.
Dr. Mazumder A, after taking into account co and confounders wrote at the end of the experiment, " sinigrin-phytosome complex augmented the therapeutic potential of sinigrin towards the wound healing activity".
Taken together, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for speedup wound healing, pending the confirmation of a large sample size and multicenter human study.
However, intake of bioactive in the form of a supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi, and Jeanetta du Plessis. (Molecules)
(2) In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex by Mazumder A1, Dwivedi A1, du Preez JL1, du Plessis J2.(Pubmed)
(3) Immune Dysfunction and Bacterial Co-Infections Following Influenza by Dennis W. Metzger and Keer Sun. (PMC)
Wound healing is a natural process of the immune system response to protect our body against harmful pathogenic invasion.
After receiving the message from the neurons in the brain, the immune first line of defense including the macrophages stimulates the blood palettes to the site of infection to cover the injury and production of pro-inflammatory cytokines to kill off the stimuli and pathogens which try to enter the body through the wound.
Some anti-inflammatory cytokines under normal conditions also switch to pro-inflammatory cytokines depending on the severity of the injury.
In some cases, overproduction of pro-inflammatory cytokines can cause damage or death of the nearby cells, leading to the formation of irreversible scars, such as hepatitis infection.
Even worse, if the immune system can not kill off all pathogens in the acute phase of infection, it will compromise the new change, leading to chronic low-grade inflammation.
Bacterial pathogens often cause infection in specific areas of the body by overgrowth of the numbers of bacteria in the site, including the gut.
According to epidemiological studies, some bacteria are opportunistic pathogens, and people with a weakened immune system are particularly prone to their invasion.
Dr. Dennis W. Metzger, the lead scientist wrote, " While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections".
The results strongly indicated the increased risk of bacterial infection in people with a weakened immune system.
Researchers on finding a natural compound for speeding up wound healing explored on wound healing effect of sinigrin on HaCaT cells.
In the phytosome with sinigrin with an average particle size of 153 ± 39 nm, the zeta potential of 10.09 ± 0.98 mV and complex efficiency of 69.5 ± 5%.
The formulated sinigrin-phytosome complex significantly exhibited a greater wound-healing effect compared to the use of sinigrin alone.
Compared to only 71% of wounds closer to sinigrin after 42 hours, the phytosome complex completely healed the wound.
At a lower concentration of 0.07 mg/mL, the sinigrin–phytosome complex displayed 79%, whilst sinigrin showed only 50% of wound closure.
At the higher concentration of 0.14 mg/mL the sinigrin–phytosome complex completely cured the wound (100%), compared to only 71% wound healing of sinigrin.
Furthermore, The sinigrin-phytosome complex displayed minimal toxicity towards HaCaT cells.
Injection of the complex also exerted a strong effect on A-375, a human melanoma cell line.
Dr. Mazumder A, after taking into account co and confounders wrote at the end of the experiment, " sinigrin-phytosome complex augmented the therapeutic potential of sinigrin towards the wound healing activity".
Taken together, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for speedup wound healing, pending the confirmation of a large sample size and multicenter human study.
However, intake of bioactive in the form of a supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi, and Jeanetta du Plessis. (Molecules)
(2) In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex by Mazumder A1, Dwivedi A1, du Preez JL1, du Plessis J2.(Pubmed)
(3) Immune Dysfunction and Bacterial Co-Infections Following Influenza by Dennis W. Metzger and Keer Sun. (PMC)
#Anthocyanoside Found in #Bilberry Exerts Neuro-Protective Property through its Antioxidant Enzyme expression, According to Studies
Kyle J. Norton
Scientists may have found a herbal remedy that processes a neuron-protective effect against brain diseases, according to studies.
Neurological disorders are diseases associated with the brain, spine, and nerves. In other words, they are diseases of the central nervous system.
There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetic preposition, and physical injury.
Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidants caused either by overexpression of free radicals or depletion of antioxidants enzymes or both.
Free radicals can be produced internally by normal cellular metabolism or from external sources such as the air we breathe, and smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.
In order for them to maintain stability, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not stop[ed until the outer ring electron is paired or inhibited by antioxidants.
Oxidative stress has been found to be a major risk for the onset of neurological disorder in the Western world, particularly in North America.
Dr. Carvalho AN, the lead scientist in the assessment of oxidative stress and antioxidants in neurological diseases, said, "Oxidative stress is a pathological feature common to a multitude of neurological diseases. The production of reactive oxygen species (ROS) is the main mechanism underlying this cellular redox imbalance".
And, "overview of the main players in oxidative stress and outline evidence of their involvement in Parkinson's disease, Alzheimer's disease, Huntington's disease, and multiple sclerosis".
The results clearly suggested the impact of oxidative stress in the facilitation of the onset of neurodegenerative diseases.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient which processes neuroprotective effects evaluated the activity of Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) against retinal damage.
According to the assays, in the retinal ganglion cells (RGCs) induced cell damage and radical activation by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1), injection of VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and free radical activation.
Furthermore, VMA also significantly inhibited the N-methyl-D-aspartic acid (NMDA)-induced morphological retinal damage compared to other derivatives. and increased apoptosis of the damaged cells in the ganglion cell layer.
Moreover, VMA at a concentration-dependently inhibited lipid peroxidation in mouse forebrain homogenates. In other words, VMA prevented the accumulation of lipid peroxidation in the neurons, the major cause of the neuron damage.
The findings suggested that VMA and its anthocyanidins process neuroprotective effects via an anti-oxidation mechanism in vitro and in vivo models of retinal diseases.
Additionally, in order to reveal more information about bilberry neuroprotective activity, researchers examined the antioxidants richly present in bilberry fruits effects on diabetes-related brain dysfunctions.
αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats before being fed with an extract of bilberry fruit showed a reduction of swollen and the lengths of the neuronal fibers.
Interestingly, diabetic rats fed with bilberry fruit showed an αCaMKII-positive nerve fiber significantly longer compared to the groups of diabetic and control rats.
The results strongly suggested that bilberry fruits influence the morphology of and possibly exhibit beneficial and neuroprotective effects on hippocampal neurons during diabetes through the expression of antioxidants.
Taken together, bilberry processed abundantly bioactive compound such as anthocyanidin and its constituents cyanidin, delphinidin, and malvidin may be considered a functional remedy for the prevention and treatment of neuro-diseases, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Contrary To Professional Prediction, Floaters Can Be Cured Naturally
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)
(2) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(3) Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? by Carvalho AN1, Firuzi O2, Gama MJ3, Horssen JV4, Saso L. (PubMed)
Scientists may have found a herbal remedy that processes a neuron-protective effect against brain diseases, according to studies.
Neurological disorders are diseases associated with the brain, spine, and nerves. In other words, they are diseases of the central nervous system.
There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetic preposition, and physical injury.
Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidants caused either by overexpression of free radicals or depletion of antioxidants enzymes or both.
Free radicals can be produced internally by normal cellular metabolism or from external sources such as the air we breathe, and smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.
In order for them to maintain stability, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not stop[ed until the outer ring electron is paired or inhibited by antioxidants.
Oxidative stress has been found to be a major risk for the onset of neurological disorder in the Western world, particularly in North America.
Dr. Carvalho AN, the lead scientist in the assessment of oxidative stress and antioxidants in neurological diseases, said, "Oxidative stress is a pathological feature common to a multitude of neurological diseases. The production of reactive oxygen species (ROS) is the main mechanism underlying this cellular redox imbalance".
And, "overview of the main players in oxidative stress and outline evidence of their involvement in Parkinson's disease, Alzheimer's disease, Huntington's disease, and multiple sclerosis".
The results clearly suggested the impact of oxidative stress in the facilitation of the onset of neurodegenerative diseases.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient which processes neuroprotective effects evaluated the activity of Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) against retinal damage.
According to the assays, in the retinal ganglion cells (RGCs) induced cell damage and radical activation by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1), injection of VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and free radical activation.
Furthermore, VMA also significantly inhibited the N-methyl-D-aspartic acid (NMDA)-induced morphological retinal damage compared to other derivatives. and increased apoptosis of the damaged cells in the ganglion cell layer.
Moreover, VMA at a concentration-dependently inhibited lipid peroxidation in mouse forebrain homogenates. In other words, VMA prevented the accumulation of lipid peroxidation in the neurons, the major cause of the neuron damage.
The findings suggested that VMA and its anthocyanidins process neuroprotective effects via an anti-oxidation mechanism in vitro and in vivo models of retinal diseases.
Additionally, in order to reveal more information about bilberry neuroprotective activity, researchers examined the antioxidants richly present in bilberry fruits effects on diabetes-related brain dysfunctions.
αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats before being fed with an extract of bilberry fruit showed a reduction of swollen and the lengths of the neuronal fibers.
Interestingly, diabetic rats fed with bilberry fruit showed an αCaMKII-positive nerve fiber significantly longer compared to the groups of diabetic and control rats.
The results strongly suggested that bilberry fruits influence the morphology of and possibly exhibit beneficial and neuroprotective effects on hippocampal neurons during diabetes through the expression of antioxidants.
Taken together, bilberry processed abundantly bioactive compound such as anthocyanidin and its constituents cyanidin, delphinidin, and malvidin may be considered a functional remedy for the prevention and treatment of neuro-diseases, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)
(2) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(3) Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? by Carvalho AN1, Firuzi O2, Gama MJ3, Horssen JV4, Saso L. (PubMed)
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