#Healthyfood StrawberriesExtract Inhibits the Onset of #ProstateCancer Through Reduction in #Cancer Cell Survival, Researchers Say

Kyle J. Norton

Scientists may have found a tasty whole fruit for the prevention and treatment of benign prostatic hyperplasia (enlarged prostate) and prostate cancer with no side effects, according to studies.

Benign prostatic hyperplasia happened mostly in the older age population group is a condition of an enlarged prostate that can cause some serious urinary symptoms, such as blocking the flow of urine out of the bladder.

In many cases, an enlarged prostate can also induce bladder, urinary tract, or kidney problems and prostate cancer.

Prostate cancer is slow growth and a medical condition characterized by cell growth disorderly and uncontrollably in the prostate tissue.

Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate gland
At the advanced stage, the cancerous cell can travel a distance away from the prostate to infect other healthy tissue, through blood and fluid circulation.

The causes of prostate cancer are unknown. Epidemiologically, researchers do know that the increase in age, ethnicity, family history, the genetic preposition of BRCA1 and/or BRCA2, and agent orange exposure is associated with an increased risk of the disease.

Some researchers suggested that poor eating habits and lifestyle are the most common risk factors associated with the onset of benign prostatic hyperplasia and prostate cancer. Therefore, by changing to a healthy diet, the risk of benign prostatic hyperplasia and prostate cancer may be preventable.

Dr. Devrim E, in the concern of the widespread of prostate cancer and benign prostatic hyperplasia (BPH), over the last few decades said, "Garlic and its preparations have been used for the treatment of prostate cancer and relief of BPH symptoms for decades. It is thought that the mechanism(s) through which garlic may show anti-cancer and anti-inflammatory effects".


These results suggested adding garlic to your diet daily can decrease the incidence of both benign prostatic hyperplasia and prostate cancer with no side effects.

Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.

Starting at age 40, the levels of the by-product prolactin of testosterone in men increase, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to dihydro-testosterones DHT triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of enlarged prostate is to naturally impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of enlarged prostate. Prostate Cancer is defined as a condition of the abnormal proliferation of cells in the prostate.

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

With an aim to find the natural compound which processes the potency to inhibit benign prostatic hyperplasia (BPH), a common disease of the prostate that affects men as they age, and a risk factor for developing prostate cancer with no side effects, researchers at the Monash University looked into the anti-BPH activity of lycopene found abundantly in the strawberry by searching the database of medical literature.

Out of many medical studies examined, only 8 published randomized controlled trials (RCTs) comparing lycopene to placebo (or other interventions) for the treatment of BPH and prostate cancer met the inclusion criteria selected for this systematic review.
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Meta-analysis of two studies indicated a decrease in PSA levels in men diagnosed with prostate cancer, who received lycopene compared to placebo.

In a human prostate epithelial cell line (P21) and two tumor cell lines (P21 tumor cell line 1 and 2) derived from the same patient, and a normal human breast epithelial cell line (B42) and a tumor line derived from it (B42 clone 16), researchers examined the cytotoxic effects of strawberry polyphenols.

By applying the polyphenol-rich extract derived from strawberry or anthocyanin or tannin-rich sub-fractions to the cell lines in doses varying from 50 to 1.5 microg/ml, researchers discovered the strawberry extract inhibited over 50% in cell survival of both the normal and the tumor lines with the doses of approximately 5 microg/ml.

The extracts were found to exert cytotoxicity to peripheral blood human lymphocytes with the doses higher levels of 20 microg/ml for a similar effect of 50% reduction in cell survival.

Compound analysis assay suggested that the cytotoxicity retained in the tannin-rich fraction was considerably more toxic to all cells (normal or tumor cell lines or lymphocytes) than the anthocyanin-rich fraction tannin-rich fraction.

Furthermore, In LNCaP and PC-3) tumor cell lines, strawberry extract with concentrations of 50 microg/ml was required for a 50% reduction in cell survival.

The finding suggested that strawberries processed with high amounts of bioactive compounds may be considered a functional food for the prevention and treatment of benign prostatic hyperplasia (BPH) and prostate cancer without inducing any side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review by Ilic D, Misso M.(PubMed)
(2) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed)
(3) Lycopene for the prevention of prostate cancer by Ilic D, Forbes KM, Hassed C.(PubMed)
(4) Is garlic a promising food for benign prostatic hyperplasia and prostate cancer? by Devrim E1, Durak I. (PubMed)

#ChineseCelery Exerts a Neuroprotective Effect Against Some Complications After #Stroke, Researchers Show

Kyle J. Norton

Scientists may have found a whole food for the treatment and improvement of the quality of life of post-stroke patients without inducing any side effects, according to studies.

Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.

In other words, a stroke can either be the result of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain inducing permanent damage.

Depending on the parts of the neuron being damaged, patients may experience different symptoms. However, the most common symptoms of stroke include paralysis or numbness of the face, arm, or leg, problems in vision, speaking, walking, and persistent headache.

Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, and ethnicity are some prevalent risk factors for stroke.

Out of many risk factors, people who have hypertension, particularly untreated hypertension, and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.


In examining the post-stroke patients, a poor diet pattern with a high of saturated and trans fat, red meat, and processed foods has been found in the high percentage, compared to the traditional diet.

Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in risk of stroke wrote, "Adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".

The statement clearly suggested that a healthy diet rich in fruits and vegetables and whole grains and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.

On finding a natural ingredient with no side effects for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.

The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of onset of ischemic stroke in China.

Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.


After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement over 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).

Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.

According to the Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.

Furthermore, a stroke inExertnti-oxidant agent prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging, and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT. (PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)

#Healthyfood #Honey Inhibits #BladderCancer Growth in Vivo and Vitro, Scientists Say

Kyle J. Norton

Scientists may have found a natural food source that processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.

Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.
Most cases of primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.

At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distant metastasis to infect other healthy tissue and organ through the circulation of blood and fluids.

At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.
Researchers do not the exact causes of bladder cancer. But certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition, and exposure to chemicals are at a higher risk of the onset of the disease.

The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.

In fact, most people with some of the above risk factors have never developed bladder cancer even if they are associated with the increased risk all their life.

Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.

Sadly, People with gene mutation are at a 70 % higher risk of bladder cancer compared to those do not.

Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for the tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of the p53 gene".


And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener;

With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.

The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).

In vitro studies, the application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.


The Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.


FCM showed a lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.

Flow cytometry (FCM). in the measurement of cancer cells physical and chemical characteristics showed lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.

Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.

These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.

And, Honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.

Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".

Taken together, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.

However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight


How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)

#AloeJuice Used as #MouthWash Inhibits #OralMucositis Induced by Radiation Therapy in Patients with Head and Neck Cancer

Kyle J. Norton

Aloe vera may have a potential effect in reducing oral mucositis in patients with head and neck cancer, some scientists suggested.
Head and neck cancer is a class of cancers that start in the mouth, throat, larynx, sinuses, or salivary glands.

In the early stage, cells on the surface of the inner lining associated with the head and neck start to grow irregularly and disorderly.

However, at the advanced stage, as cancer has penetrated into the deeper layers, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.

In some cases at the advanced stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

The most common head and neck cancer metastases are secondary skin cancer.

Oral mucositis is one of the common side effects in cancer patients who are under chemo and radiation treatment, leading to symptoms of pain, nutritional problems as a result of an inability to eat, and an increased risk of infection due to open sores in the mucosa.

The symptom has been found to reduce the quality of life of cancer patients.

According to The Oral Cancer Foundation, patients experience the side effect of oral mucositis after 5 to 10 days of chemotherapy. Normally, the side effect will disappear in short few weeks, depending on the types of medicine, doses, and duration of the treatment.

Dr. Begonya Chaveli-López, the lead author in the study "Treatment of oral mucositis due to chemotherapy" wrote, "Very few interventions of confirmed efficacy are available for the management of oral mucositis due to chemotherapy. However, according to the reviewed literature, the use of palifermin, cryotherapy, and low-power laser offer benefits, reducing the incidence and severity of oral mucositis".

On finding a natural and effective ingredient for the treatment of oral mucositis with no side effects, researchers examined the topical Aloe vera, a widely used for mild sunburn, frostbites, and scalding burns for its effect on mucositis.

Aloe gel showed the beneficial effects of wound healing, mucous membrane protection, and treatment of oral ulcers.

Application of Aloe gel also enhanced the anti-inflammatory, immunomodulation, antifungal, scavenging free radicals, increasing collagen formation, and inhibiting collagenase, epidemiological studies suggested.

Oral Aloe vera mouthwash demonstrated significant prevention of radiation-induced mucositis through its wound healing and anti-inflammatory mechanism.
The herbal mouthwash also reduced oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.

These efficacies indicated that Aloe vera mouthwash may be considered an alternative potential for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.

Futhermore, in the finding the most effective agent for treatment of oral mucositis, the Haji Mirza Mohammad conducted a triple-blind, randomized controlled trial in the comparison of the Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation-induced mucositis in the head and neck cancer patients.


The trial included 26 eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department and were randomized to receive an Aloe vera mouthwash or a benzydamine mouthwash.

No difference in the distribution of mucositis severity between the two groups, at the baseline.

The mean interval between radiation therapy and the onset of mucositis was similar for both groups.

The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days).

According to the comparison test researchers suggested that the Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancer due to its exertion of the similar effects as of those of beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis with no side effects.

Taken together, herbal Aloe vera juice may be considered a functional juice for the treatment of the side effect of oral mucositis caused by chemo and radiation therapy in patients with head and neck cancer

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.




Sources
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(3) Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial by Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, Manifar S, Ashnagar S, Doroudgar K.(PubMed)

6-Gingerol Found in Ginger Alleviated #LiverSteatosis, and #Inflammation By Inhibiting the Expression of Proinflammatory Cytokines, Studies Find

Kyle J> Norton


Scientists may have found pungent and kitchen spices which process a potential effect on the prevention and treatment of chronic inflammatory diseases without inducing any side effects.

Inflammation is a natural reaction of the immune system whose function is to protect our body against the invasion of foreign stimuli and pathogens.

In the acute phase of tissue damage or injury, the white blood cells responsible for the first line of defense activate the production of the inflammatory cytokines to the site of infection with an aim to kill off the invasive agents.

However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells and lead to improper healing with the formation of scars.

Chronic inflammation is an inflammation that lasts more than 3 months. The development and progression of chronic inflammatory diseases are the results of the immune system which can not kill off the invasive pathogens in the acute phase of infection or the immune system mistakenly attacks the body tissue, leading to persistently low-grade inflammation.

In the further analysis of the evolution of physiological supersystems involved in chronic inflammatory disease, Dr. Rainer H. Straub, the lead author said, "It is predicted that genes that protect energy stores are positively selected (as immune memory). This could explain why energy-demanding inflammatory episodes like infectious diseases must be terminated within 3–8 weeks to be adaptive, and otherwise become maladaptive:

These results suggested that the genes and networks used evolved during physiological supersystems, fitness consequences, and during different life-history stages are positively selected if they serve acute, highly energy-consuming inflammation.


In other words, the immune system becomes maladaptive, if inflammation does not terminate within eight weeks of infection.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The kitchen has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient for the treatment of inflammation without inducing any adverse effects, a joint study led by the CHA University, Seongnam was conducted to examine the molecular mechanism of 6-gingerol on adipocyte-mediated systemic inflammation in vitro and in high-fat-diet-induced obese zebrafish.


Injection of 6-gingerol exerted significantly increased the production of anti-inflammatory cytokine interleukin-10 and decreased the expression of proinflammatory cytokines, TNFα, monocyte chemotactic protein-1, interleukin-1β, and interleukin-6.

In the RAW 264.7 macrophages, 6-gingerol inhibited the protein expression of proinflammatory factors TNFα and monocyte chemotactic protein-1, a small cytokine that belongs to the CC chemokine family.

6-Gingerol decreased c-JUN N-terminal kinase and I kappa B kinase beta which plays an important role in the inhibition of nuclear factor kappa-B kinase activated by multiple stimuli such as inflammatory cytokines

Where JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes including inflammation.

6-gingerol also decreased the expression of inducible nitric oxide synthase in the stimulation of the expression of inflammation.

Dr. Choi J, the lead scientist wrote in the final report, " 6-gingerol suppresses inflammation through the regulation of the c-JUN N-terminal kinase-I kappa B kinase beta and its downstream targets".

Furthermore, the investigation of the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanoate) in experimental models that HepG2 cells were exposed to 500 µmol/l oleic acid (OA) for 24 h and preincubated for an additional 24 h with 6-gingerol (25, 50 or 100 µmol/l). 6-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells of non-alcoholic steatohepatitis also suggested that
* Daily application of 6ginger for 8 weeks while maintained on HFD. 6-Gingerol (100 mg/kg/day) alleviated liver steatosis, and inflammation, and reversed

* [6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.

The results strongly indicated 6-Gingerol attenuates HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.

More interestingly, the study includes five groups of rats containing 14 rats/group received corn oil (control), CPF (5 mg/kg), 6-GRF (100 mg/kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg) + 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively, researchers showed that

* Before 6-gingerol application CPF-induced rats showed an increase in oxidative stress ((hydrogen peroxide (H2O2) and malondialdehyde (MDA)), inflammatory (myeloperoxidase (MPO), nitric oxide (NO) nitric oxide (NO) and tumor necrosis factor-α (TNF- α)), and apoptotic (caspase-3) markers.

* Injection of 6-gingerol attenuated all factors in the CPF-induced rats.

* 6-GRF reduced the inflammatory expression by improving the activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary, and uterus of rats exposed to CPF.

Dr. Abolaji AO the lead author said, "The protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to its potent antioxidative, anti-inflammatory, and antiapoptotic properties".

Where Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and household environments.

Taken together, ginger processed abundantly 6-gingerol may be considered a functional kitchen spice for the prevention and treatment of liver steatosis and inflammation.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) 6-Gingerol Suppresses Adipocyte-Derived Mediators of Inflammation In Vitro and in High-Fat Diet-Induced Obese Zebra Fish by Choi J1, Kim KJ1, Kim BH2, Koh EJ1, Seo MJ1, Lee BY. (PubMed)
(2) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(3) Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary, and uterus of rats by Abolaji AO1, Ojo M2, Afolabi TT2, Arowoogun MD2, Nwawolor D2, Farombi EO. (PubMed)

#Bilberry #Anthocyanin Extract Induces #HealthyAgings By improving the Decreased Activity of Digestive Enzymes in Breaking Down the Proteins into Amino Acids

Kyle J. Norton

Scientists may have found a natural and herbal remedy for the improvement of digestive gut microbiota for health optimization, according to studies.

Gut microbiota, or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts plays a critical role in a variety of metabolic functions, including producing vitamins, synthesizing all essential and nonessential amino acids, and carrying out biotransformation of bile.

Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.

From the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system in inducing the proinflammatory cytokines.


However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of diseases such as obesity, and type 2 diabetes.

Imbalanced gut microbiota is found in obese patients, compared to healthy-weight individuals.


Dr. Kyle J. Wolf, the lead scientist in the investigation of the link between obesity and gut microbiota, wrote, "
In recent years it has been definitively shown that microbiota in the gastrointestinal tract is altered in obese individuals".

And, "Normal humans and mice have 60% to 80% Firmicutes (which are primarily nonculturable, butyrate-producing Clostridium cluster XIVa) and 20% Bacteroidetes (Cytophaga-Flavobacterium-Bacteroides). However, the obese mouse model (ob/ob) had a 50% reduction in Bacteroidetes and an increase in Firmicutes. A similar decrease in Bacteroidetes and increase in Firmicutes is also seen when C57BL/6 mice are fed a high-fat (HF) diet".

The results in the mice model study strongly linked the Western diet and the risk of imbalanced gut microbiota in facilitating the onset of obesity.

Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Scientists on finding a natural ingredient for the improvement of digestive system functioning in the elderly examined bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity.

In the aging rats selected for the study, injection of medium-dose bilberry anthocyanin at 20 mg per kg bw per day) showed to optimize intestinal function.

Analyzing the gut microbiota, consumption of bilberry anthocyanin balanced the levels of bacteria in the intestine by increasing the good bacteria such as Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7- and the Lachnospiraceae_NK4A136_group) and decreasing the levels of harmful bacterias, such as Verrucomicrobia and Euryarchaeota.

However. injection of any dose higher than 20 mg per kg displayed the alternation of some intestinally beneficial bacteria in an adverse way.

Furthermore, besides improving the levels of gut microbiota, consumption of bilberry anthocyanin also induced changes in short-chain fatty acids and the intestinal mucosal barrier, correlatedly.

In other words, the injection of the extract consumption also improved the decreased activity of digestive enzymes in breaking down the proteins into amino acids due to aging.

Dr. Li J, the lead scientist wrote, "Bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".

Moreover, in order to reveal more information about bilberry gut microbiota effects, researchers compared bilberries and cloudberries, the 2 berries on the. intestinal immune responses and gut microbiota.

Injection of bilberry not only reduced the expression of pro-inflammatory cytokines through immunomodulatory activity but also improved the balance of the gut microbiota compared to cloudberries and the control group.

Interestingly, cloudberry inhibited and bilberry exhibited the expression of energy metabolism-related genes in the intestinal mucosa.

Additionally, the microbial profiles of cloudberry-fed mice clustered together and associated with small adenoma size compared to the bilberry group.

The findings suggested that bilberry consumption demonstrated potential digestive health by attenuating intestinal inflammation, improving microbial profiles, and exhibiting mucosal energy metabolism.

Taken altogether, bilberry processed with a high amount of bioactive compound may be considered a functional remedy for optimizing bodily health by balancing the levels of gut microbiota.


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X. (PubMed)
(2) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M. (PubMed)
(3) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, Ph.D. and Nigel T. Plummer, Ph.D. (PMC)
(4) Gut Microbiota and Obesity by Kyle J. Wolfa and Robin G. Lorenz. (PMC)

#Ginger Extract Inhibits the Oxidative DNA Damage and #Oxidativestress Through Its Antixodant Activities, Researchers Show

Kyle J. Norton

Intake of one or 2 slices of ginger daily and regularly may have a strong effect in stimulating the production of antioxidant enzymes in the body against the onset of oxidative stress, scientists found.
Oxidative stress is a result of the overexpression of free radicals, compared to the levels of antioxidants in the body.

Free radicals are highly reactive and unstable atoms with the unpaired electron on the outer ring of the molecules, therefore, in order to become stable, they must donate or steal an electron from other stable molecules, leading to chain activity that can not be stopped until they are paired or inhibited by antioxidants.

There are many factors associated with the production of free radicals, including the food we eat, the medicines we take, the air we breathe, and the water we drink.

In other words, free radicals can be generated by alcohol, tobacco smoke, pesticides, and air pollutants.

Antioxidants are stable atoms that inhibit oxidation caused by free radicals.

Some researchers suggested the prolonged presence of oxidative stress can cause damage to the cells, proteins, and alteration of DNA, leading to chronic diseases.

Dr. Eiichiro Ichiishi and colleagues in the concern of the effects of oxidative stress on the risks of diseases showed that oxidative stress not only has a strong implication in the development of diseases but also affects the outcome throughout the course of organ transplantation.
Additionally, the team wrote, "Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome".

"Xeroderma pigmentosum group A (XPA) is a genetic disorder in DNA nucleotide excision repair (NER) with severe neurological disorders, in which oxidative stress and disturbed melatonin metabolism may be involved".

"Renal transplantation has been considered the best therapeutic option for end-stage renal disease,...determine the effect of renal transplantation on the evolution of oxidative DNA status,".

"Cigarette smoking is the most important risk factor for the development or deterioration of Graves' ophthalmopathy. Smoke-induced increased generation of reactive oxygen species may be involved".

These results indicated the important roles of antioxidants which inhibited oxidative stress before they can cause a wide range of damage to the human body.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find the best possible antioxidative stress natural ingredient or whole food, researchers examined the protective effects of ginger (Zingiber officinale Roscoe) extract on IL-1β-mediated oxidative stress and mitochondrial apoptosis in C28I2 human chondrocytes.
The cells were pretreated with 5 and 25 μg/mL ginger extract for 24 h, followed by incubation with IL-1β (10 ng/mL) for 24 h.

At the end of the study, ginger extract demonstrated a significant effect in the inhibition of IL-1β-induced intracellular reactive oxygen species (ROS) production and lipid peroxidation.


Ginger extract pretreatment also remarkably increased the gene expression of antioxidant enzymes.

The elevated levels of the Bax/Bcl-2 ratio and caspase-3 involved cell apoptosis were also normalized by the application of ginger extract.

The finding clearly indicated ginger extract could considerably reduce IL-1β-induced oxidative stress and consequent mitochondrial apoptosis as the major mechanisms of chondrocyte cell death and the efficacy was attributed to its antioxidant activity.

In pulmonary abnormalities tested mice induced by chronic ethanol exposure, researchers evaluated whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats.

The study included male Wistar rats divided into the control group, the ethanol group, and the ethanol plus ginger extract group.

The ethanol group after six-week of treatments increased the proliferation of lung cells, and induced fibrosis, inflammation, and leukocyte infiltration.

The levels of -hydroxydeoxyguanosine, NADPH oxidase, and oxidized low-density lipoprotein were also found to increase substantially in the ethanol-treated group.

The application of ginger extract normalized such changes by inhibiting oxidative DNA damage and oxidative stress.

Taken altogether, ginger extract may be considered a natural antioxidative stress ingredient by enhancing the production of antioxidants and protecting the body against inflammation.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(2) Protective Effect of Ginger (Zingiber officinale Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes by Hosseinzadeh A1, Bahrampour Juybari K, Fatemi MJ, Kamarul T, Bagheri A, Tekiyehmaroof N, Sharifi AM. (PubMed)
(3) Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats by Shirpoor A1, Gharalari FH2, Rasmi Y3, Heshmati E4. (PubMed)
(4) Oxidative Stress and Diseases: Clinical Trials and Approaches by Eiichiro Ichiishi, 1, * Xiao-Kang Li, 2 and Eugenio L. Iorio. (PubMed)