#Ginger Exerts Protective on #Obesity and its Complications inVitros, Researchers Find

Kyle J. Norton

Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.

Obesity is a medical disease associated with extreme overweight.

In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese.

What causes obesity? Some researchers suggested that too much calorie consumption and lack of physical exercise are the 2 main causes of obesity in once-healthy individuals.

Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of Americans and the promotion of the Western diet in the past few decades.

Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".


And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet or even a lack of essential vitamins and minerals".

These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.

Application of ginger in vivo and in vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,

Diet-induced obesity was attenuated in C57BL/6J mice treated with the dietary ginger extract (GE) and also exhibited an increase in energy expenditure.

GE also exerted an anti-obesity effect by promoting the increased number of Types I muscle fibers, running endurance capacity, and upregulated PPARδ-targeted gene expression in skeletal muscle

Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.

After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".

Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).

In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.

Dr.Suk S the lead authors said at the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".

Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in the obese subjects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.





Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)

#Phytochemical #Betanin Normalizes the High Blood Pressure Induced by #Dexamethasone in Vivos, Researchers Say

Kyle J. Norton

Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart function in pumping blood to the body.

Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and types 2 diabetes

Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.

Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, shortness of breath, early signs of heart disease, and stroke.

According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.

Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taking into account.

Sadly, only half of the people with high blood pressure in the US are under control.

There are 2 types of hypertension, including primary hypertension that takes years to develop and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.

Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.

Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".

And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".

The results strongly suggested the high-fat diet induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.


Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard, etc.

On finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.

The study included animals divided into six main groups with each group containing 5 animals.

* Group I received the vehicle,

* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,

* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,

* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,

* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and

* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.

At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to Dexamethasone group.

According to the tested assays, Dexamethasone treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), and vascular reactivity changes to Catecholamine, compared to the control group.

Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone administered rats significantly (p<0.05) demonstrated a significant reversal of such change.

Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".

In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.

Taken altogether, betanin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB dDily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)

#CucumberLeafExtract Exerts Neuron Protection by Increased Production of #PlasmaDopamine, and Melatonin and Stimulated New Blood Vessels Growth and Antioxidants

Kyle J. Norton

Neuroprotection is mechanisms and strategies associated with the protection of the brain functioning through the use of agents, including herbal medicines.
In other words, the neuroprotective effect is to protect the integrity of the viability of the neuron against nerve injury or degeneration that affects the central nervous system functioning.

Neurological disorders are diseases of the central nervous system including the brain, spine, and the nerves that connect them. 

The most common diseases associated with neurological disorders in the elderly are dementia.

In the elderly, the most common types of neurodegenerative diseases are
* Alzheimer's disease
Alzheimer's disease is a brain disorder that destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.


Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of degeneration of the hippocampus and cerebral cortex of the brain where memory, language, and cognition are located.

* Absence of acetylcholine
If the nerves located in front of the brain perish causes the diminished quality of acetylcholine that affects language difficulty, memory loss, concentration problems, and reduced mobile skills.

* Dementia due to long-term alcohol abuse
Dementia is common in patients with alcoholism. The most classic is Korsakoff's dementia which affects short-term memory and is often associated with memory loss.

* Multi-infarct dementia
Also known as vascular dementia, is the second most common form of dementia after Alzheimer's disease in older adults caused by different mechanisms all resulting in vascular lesions in the brain.

5. Parkinson's disease
Parkinson's disease (PD) is a disabling, progressive condition associated with the cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and that parallel the motor loop.

6. Creutzfeldt-Jakob disease (CJD)
People who have eaten contaminated beef for many years may be infected without even knowing it. Creutzfeldt-Jakob disease is a quickly progressing and fatal disease that consists of dementia, muscle twitching, and spasm.

7. Subdural hematoma
It is the accumulation of blood beneath the outer covering of the brain that results from the rupture of a blood vessel. Subdural hemorrhages may cause an increase in intracranial pressure.. Acute subdural hematoma has a high mortality rate.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound that processes neuroprotective properties, researchers investigated cucumber leaf extract against oxidative stress-induced neuron dysfunction associated with diabetes mellitus.

The study included 30 adult male albino rats divided into 5 groups (n=6) including a normal control group and four diabetic groups.

Single intraperitoneal injections of streptozotocin (STZ; 60 mg/kg bw) induced diabetes rats were also assigned to the untreated diabetic control group compared to the other three other groups treated with cucumber leaf extract at the doses of 30, 60, and 120 mg/kg bw for 30 days.

According to brain evaluation, treated rats showed a significant effect in lowering the levels of blood glucose, and glycated hemoglobin.

Proinflammatory expression and neurons oxidative stress in the brain is also decreased observed by the levels of tumor necrosis factor-alpha and interleukin levels, and brain malondialdehyde content, respectively.

Furthermore, a protein associated with programming neuron death was inhibited by the injection of cucumber leaf extract compared to the control.

The efficacy of cucumber leaf extract that exerts neuron protection was attributed to the increased production of plasma dopamine, and melatonin in the promotion of brain activity accompanied by stimulating the growth of new blood vessels and antioxidants produced by the host.

In other words, cucumber leaf extract improved brain function not only through its anti-inflammatory and antioxidant properties but also through the promotion of energy supply to the brain cells.

Based on the findings, researchers wrote, "It can be concluded that the C. melo var. flexuous leaf extract exerts a neuroprotective effect against oxidative damage associated with diabetes".

Taken altogether, cucumber leaf extract may be used as a neuroprotective supplement, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective effect of Cucumis melo Var. flexuous leaf extract on the brains of rats with streptozotocin-induced diabetes by Ibrahim DS. (PubMed)
(2) Dementia - Types of Dementia by Kyle J. Norton

#TualangHoney Shows a Significant Improvement In Memory Performance, by Decreasing #Oxidativestress and Stress Levels

Kyle J. Norton

Honey may have a profound and positive effect on boosting human memory, some scientists suggested
Memory is a process of the mind in learning and storing information.

Memory impairment is a condition of not remembering new and current events which may be recalled in a short period of time, affecting mostly the older population.

Memory impairment is an early symptom associated with late-life neurodegenerative diseases.

In contrast to general belief, memory impairment not only is associated with the progression of neurodegenerative diseases but also can be caused by other factors such as medical conditions including stroke and brain injury.

Long-term use of certain medications such as antidepressants, antihistamines, anti-anxiety medications, excessive alcohol drinking, substance abuse, and tobacco are some major risk factors associated with the onset of memory loss.

Some researchers suggested that people who are living under long-term stress and anxiety or follow a nutritionally deficient diet are most vulnerable to the condition developing.

According to the article "Stress might lead to memory loss and brain shrinkage, study says" By Sandee LaMotte, CNN wrote, "If you live a high-stress life, you could have memory loss and brain shrinkage before you turn 50, according to a study published Wednesday in the journal Neurology".

"Higher levels of cortisol, a stress hormone, seem to predict brain function, brain size, and performance on cognitive tests," said study author Dr. Sudha Seshadri, professor of neurology at UT Health San Antonio.

"We found memory loss and brain shrinkage in relatively young people long before any symptoms could be seen," Seshadri said. "It's never too early to be mindful of reducing stress."


In other words, long-term stress can induce the production of certain hormones such as cortisol which have strong implications on the brain in the induction of memory loss.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener 

In finding the correlation and association between aging and stress exposure and memory impairment, researchers examined the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress.

Tested rats were given orally, 200 mg/kg body weight of Tualang honey supplementation for 28 days, before exposing to loud noise, 100 dB(A), 4 hours daily for 14 days.

Rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress, through the increased expression of oxidative stress markers, elevated malondialdehyde, and protein carbonyl levels.

The stress rats also exhibited a reduction in the levels of antioxidant enzymes compared to the nonstressed rats.

Tualang honey supplementation applied to the stress rats showed a significant improvement in memory performance, by decreasing oxidative stress levels and increasing the brain-derived neurotrophic factor (BDNF) concentration, which was reduced due to stress.


Furthermore, Tualang honey also normalized the ratio of free radicals and antioxidants in the stress rats' bodies and enhanced neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus associated to memory, particularly, in long-term memory.

Dr. Azman KF, the lead scientist in the final report wrote, "Tualang honey protects against memory decline due to stress exposure and/or aging via enhancement of mPFC and hippocampal morphology possibly secondary to a reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system".

The results underlined the effects of the Tualang honey effect in boosting short and long-term memory which was significantly reduced by stress exposure and/or aging.

Moreover, in the study of a total of forty-eight adult male rats randomly divided into the following four groups: i) nonstressed with a vehicle, ii) nonstressed with Tualang honey, iii) stressed with a vehicle, and iv) stressed with honey with supplement was given once daily via oral gavage at 0.2 g/kg body weight, researchers found that
* The rats subjected to noise stress were found to process higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats.

* Tuatang honey supplementation regimen successfully counteracted the effects of noise stress.

* Tualng honey also increased the climbing and swimming and mobility times significantly.

These results suggested that Tualang honey normalizes the cognitive function of the rats exposed to noise stress, similar to those of the first study.

Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cognitive impairment, pending the larger and multi-center human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats by Azman KF1, Zakaria R1, Abdul Aziz CB1, Othman Z2. (PubMed)
(2) Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress by Azman KF1, Zakaria R, AbdAziz C, Othman Z, Al-Rahbi B. (PubMed)
(3) Potential Role of Honey in Learning and Memory by Othman Z1, Zakaria R2, Hussain NHN3, Hassan A4, Shafin N5, Al-Rahbi B6, Ahmad AH. (PubMed)

#DryTomatoPeel (DTP) Improves the #Lycopene Concentration and Reduces the Development of Indicators of #MetabolicSyndrome in Diabetes, Researchers Show

Kyle J. Norton

Glucose intolerance is a condition of the cluster of metabolic conditions associated with higher-than-normal blood glucose levels.
Glucose tolerance is a test that examines how fast glucose is cleared from the blood.

Glucose intolerance is found in people with pre-diabetes or metabolic syndrome, the condition of elevated blood glucose that is below the diabetes

* Impaired fasting glucose (IFG), a fasting blood glucose level that is above 6.0 mmol/L

* Impaired glucose tolerance (IGT), a blood glucose level that is over 7.8 mmol/L 2 hours after consuming 75g of glucose.
Glucose intolerance has been found to induce the risk of insulin resistance and increase the risk of cardiovascular disease and type 2 diabetes.

The most common symptoms of IGT are feeling thirsty, being tired or lethargic, frequent urination, and itchiness around the genitals.,

Out of many prevalent factors associated with the risk of IGT, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong and negative impact on the rise of glucose intolerance.


Dr. April J. Stull, wrote, "Glucose intolerance is a global health concern that encompasses glucose metabolism abnormalities such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2D)".


And "The progression from IGT to T2D can be prevented or delayed by modifying the lifestyles in high-risk individuals, and these health benefits are well documented in various ethnicities with prediabetes across the world".

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.


With an aim to find a phytochemical for the improvement of glucose tolerance, researchers examined the effects of dry tomato peel (DTP) on diabetes induced by a high-saturated-fat (HSF) diet in vivo.

The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) randomly divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP for 12 weeks.

According to the results of the tested assay, supplementation with DTP not only increased plasma lycopene concentration but also reduced the development of indicators of metabolic syndrome which was found in non-DTP treated groups.

In other words, DTP supplementation demonstrated a beneficial effect on glucose tolerance by increasing insulin sensitivity in the tested subject.
Also, in high-fat diet (HF)-induced obese mice treated with tomato vinegar beverage (TVB), researchers found that TVB not only showed a significant anti-obesity activity by decreasing fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice but also improved glucose tolerance, hyperinsulinemia compared to control.

More precisely, TVB exerted an anti-diabetic effect by TVB significantly increasing glucokinase activity and decreasing glucose-6-phosphatase activity in the liver, associated with enhanced glucose metabolism in obese mice.

The findings strongly suggested that TVB inhibits glucose intolerance in obese mice through several mechanisms, including glucose metabolism.

Taken altogether, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for the improvement of glucose tolerance, pending to large sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) Lifestyle Approaches and Glucose Intolerance by April J. Stull, Ph.D., RD. (PubMed)

#Herbal #Bilberry Promotes the Lipid-Protein Profiles in Reducing the Risk of #CardiovascularDisease #CVD, Researchers Find

Kyle J. Norton

The lipoprotein profiles or lipoprotein parameters are a general term comprised of the traditional lipoprotein profile including total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride.

Total cholesterol is the total amount of cholesterol in your blood, including the low-density lipoprotein (LDL, or “bad”) cholesterol and high-density lipoprotein (HDL, or “good”) cholesterol.

The healthy ratio of blood cholesterol is less than 4 of the low-density lipoprotein to 1 of the high-density lipoprotein.

Where low-density lipoprotein is produced by the liver or from food sources needed for the cells to build strong membranes, and produce steroid hormones, vitamin D, and bile to aid the digestive system in absorbing nutrients and fluids.


And high-density lipoprotein produced by the liver or from external sources is needed to return the low-density lipoprotein back to the liver.

Triglycerides, an important measure of heart health is the fat in the blood caused by the over-consumption of foods containing fat, carbohydrates, and simple sugars.

Factors that affect your lipoprotein profiles can be unpreventable including age, gender, race, and genetic preposition, and preventable such as diet, weight, physical activity, and smoking.

Some researchers suggested that people who are obese are at a substantially higher risk of poor lipoprotein profiles.


Dr. Pandolfi C, the lead scientist wrote, "Lipid pattern has resulted in overlapping both in the two studied populations and in the two subgroups of pre-and postmenopausal women, while greater concentrations of Lp(a), (p < 0.001) and t-PA (p < 0.05) have been found in obese populations vs controls".

Bilberry is a species of low-growing shrub in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

In the urgency of finding natural sources of plant-based compounds for the prevention of cardiovascular disease (CVD), researchers investigated regular consumption of bilberries in CVD risk reduction.

Women (n=25) and men (n=11) selected for the study received 150 g of frozen stored bilberries 3 times a week for 6 weeks. All parameters associated with the risk of CVD were measured by standard assays.

In both sexes, the consumption of bilberries led to a decrease in the parameters of lipoprotein profiles, including total cholesterol, LDL-C, TG, and a positive increase in HDL-C.

However, in men, additionally, favorable changes were observed in total cholesterol (P=.004), reduced oxidative stress, and HDL-C, but an increase in LDL-C compared to the women group.


In other words, the regular intake of bilberries can be important to reduce CVD risk, by promoting a decrease of LDL-C/TG and an increase of HDL-C.


Furthermore, in order to reveal more information about bilberry against CVD risk, researchers compared consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD, 1:1), or frozen bilberries on metabolic profiles.

In a total of 80 women selected to complete this randomized crossover study for 30 d, all interventions induced a significant effect on the overall metabolic profiles, particularly in lipid parameters observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B) and in participants who had a lower-risk profile (group A).

However, the bilberries treatment group caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.

The finding clearly suggested bilberries modulated the parameters of lipids and lipoproteins depending on the risk of CVD.

Dr. Larmo PS, after taking into account co and confounders wrote, "Berry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline (including bilberry)".

Taken altogether, bilberry may be considered a functional remedy for the promotion of lipid-protein profiles in reducing the risk of CVD, pending the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(3) [Lipoprotein(a), parameters of lipid metabolism and hemostasis in obese patients].[Article in Italian] by Pandolfi C1, Pellegrini L, Dedè A, Lo Vecchio M, Mercantini F. (PubMed)

#Bromelain Shows a Significant Effect on Debridement in #ChronicWounds, Researchers Find

Kyle J. Norton

A chronic wound is a wound that does not heal within a predictable period of time.
It may be a result of the interruption of the stage of wound healing or damage of the blood vessels that have a function in providing necessary conditions to promote the closure of the wound as seen in a diabetic leg ulcer.

In other words, any wound that does not heal within 3 months is considered a chronic wound.

According to the statistics provided by the study "An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds", approximately, 2% of the population in developed countries suffer from chronic wounds.

Additionally, every year, more than 305 million cases of acute, traumatic, and burn wounds are treated globally.

Believe it or not, chronic and acute wound affects more than nine times of people around the world compared to those living with cancer.

Some researchers suggested that pressure, trauma, and/or lower extremity wounds, increased bacterial load, interruption of the stage of wound healing including excessive proteases, degraded cell surface structures, and inappropriate treatment are considered the most potent causes of the conditions.

More precisely, if we can protect all stages of wound healing without interruption, the chronic wound can be preventable.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent for the treatment of pains, strains, muscle aches and pains and to ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for the treatment of chronic wounds, researchers examined the efficacy of bromelain-based enzymatic debridement of chronic wounds.

The study included 24 patients with chronic wounds of different aetiologies.


According to 2 consecutive single-arm studies assessing the enzymatic debridement efficacy in 2 medical centers, all wounds achieved an average of 68% ± 30% debridement in an average of 3.5 ± 2.8 enzymatic debridement 4-hour sessions.


17/24 patients showed responding wounds (venous, diabetic, pressure, and post-traumatic aetiologies) of an average of 85% ± 12% debridement in 3.2 ± 2.5 applications, compared to 7/24 patients with no response.

There were no adverse effects reported by the patients. Based on the findings, researchers wrote, "These preliminary results indicate the potential safety and efficacy of bromelain-based enzymatic debridement in chronic wounds".

In vitro, according to the results of two soft tissue healing--fibroblasts and microvascular endothelial cells--were used as mono- and co-culture with bromelain, bromelain attenuated endothelial cell, and fibroblast proliferation moderately.

The inhibition of cell proliferation was not associated with cell apoptosis but with cell cycle arrest in the G0 phase.

In the comparable test, bromelain did not reduce endothelial cell migration. whereas fibroblast migration was clearly slowed down.


In other words, bromelain displayed a significant decrease of myofibroblasts under both normoxic (from 19 to 12 %) and hypoxic conditions (from 22 to 15 %) coincident with higher levels of anti-inflammatory expression.

Based on the findings, researchers wrote, "Usage of bromelain as a therapeutic drug for chronic human wounds thus remains a very promising concept for the future".

Taken altogether, bromelain used alone or combined with other remedies may be considered a supplement for the prevention and treatment of chronic wounds, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain-based enzymatic debridement of chronic wounds: A preliminary report by Shoham Y1, Krieger Y1, Tamir E2, Silberstein E1, Bogdanov-Berezovsky A1, Haik J3, Rosenberg L. (PubMed)
(2) Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay by Aichele K1, Bubel M, Deubel G, Pohlemann T, Oberringer M. (PubMed)