#Herbal #Turmeric Protects the Digestive System by Balancing Ratio of Gut Microbiome Composition, According to Studies

Kyle J. Norton

Gut microbiota is a community of microbes living in the gastrointestinal tract.Believe it or not, there are over trillions of microorganisms, including at least 1000 different species of known bacteria with more than 3 million genes.

In a healthy individual, the ratio of good and bad microbes in the gut is balanced. However, people who are under constant stress or have a psychological condition such as anxiety, and depression, and long-term use of antibiotics may have a negative impact on the ratio.

In other words, emotional problems, the use of antibiotics may alter the ratio of the microbes in the gut, leading to inflammation, oxidative stress, and blood sugar imbalances.

Dr. Ruth K. Dudek-Wicher, the lead scientist wrote, "Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders".

And, "...the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp.".

More precisely, an imbalanced gut community microbes ratio can induce certain health problems including
* Decreasing the interaction with the immune function against inflammatory immune disorders.

* Increasing the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Reducing nutrient extraction from the diet, thus increasing the risk of obesity and obesity complications.

* Failure to control brain insulin signaling and metabolite levels can lead to bad neurobehaviors.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a natural compound for the improvement of bacterial composition in the gut, researchers
examined the effects of curcumin on the gut microbiota in dysbiosis, a condition that links to many metabolic diseases.

According to the tested assays, curcumin and its derivatives exerted direct regulative effects on the gut microbiota by increasing the ratio of bacteria composition in the flavor of good bacteria.

Futhermore, in the testing the turmeric tablets in the gut microbiota determined by 16S rDNA sequencing, researchers divided.14 healthy human subjects were into 3 groups with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3).

According to the bacterial analysis, turmeric-treated subjects displayed a modest 7% increase in observed species compared to control with an overall reduction in species by 15%.

Moreover, curcumin displayed an average increase of 69% in detected species, depending on the gut microbiota response to individual subjects.

More precisely, in "responsive" subjects curcumin increased in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. and reduced relative abundance of several Blautia spp. and most Ruminococcus spp.


In other words, curcumin improved the ratio of gut microbiota by stimulating the production of "good bacterial and reducing the levels of "bad" bacteria in the colon.


Based on the findings, researchers wrote, "All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner".

Taken altogether, turmeric may be considered a supplement for the prevention and treatment of an imbalanced ratio of gut microbiome composition, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence by Zam W. (PubMed)
(2) Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study by Peterson CT1, Vaughn AR2,3, Sharma V4, Chopra D1,5, Mills PJ1, Peterson SN4, Sivamani RK. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher, Adam Junka, and Marzenna Bartoszewicz. (PMC)

#Bromelain Combined with #Diclofenacgroups in Reducing Pain and Swelling and Quality of Life in Patients after Surgical Removal of Impacted LowerThird Molars

Kyle J. Norton 

Pain and swelling is a natural response of the immune and nervous system after a wound or injury by inducing the production of proinflammatory cytokines.

In acute of infection, after sensing a wound and injury to the body, the immune first lines of white blood cell defense stimulate the production of blood palette to the infected area with an aim to cover the wound or injury and the inflammatory cytokines to kill off organisms trying to enter the body through the opening.

Please note that overexpression of proinflammatory cytokines in this phase has been found to cause abnormal healing with the formation of scars.

The acute phase of infection arrives and leaves quickly as it is resolved quickly by the body.

However, chronic infection is a result of an immune system that can not kill off all infectious organisms in the acute phase of infection, leading to chronic inflammation that last a long time, such as months or years.

Swelling and pain in the joints are one of the most common symptoms in patients with arthritis, particularly in rheumatoid arthritis (RA).

However, some cases of swelling accompanied by symptoms that do not associate to the injury such as fatigue, loss of appetite, and weight gain may be an indication of cancer, heart, liver, or kidney disease.

If you experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility.


In most cases, pain and swelling of the injury and wound can be healed by themselves without interfering or injection of counter-pain medication, depending on the size of the opening.


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find potential and natural compounds for the treatment of pain and swelling with no side effects, researchers evaluated the effect of bromelain after the surgical removal of third molars.

The prospective randomized clinical study included 40 patients requiring surgical removal of impacted mandibular third molars.

After the surgery, according to the tested assays, bromelain showed a significant effect in reducing swelling and pain in 28 out of a total of 40 patients.


Based on the findings, researchers said, "Bromelain can be used as a successful oral enzyme therapy for oral surgery patients, especially after removal of impacted third molars".

In order to reveal more information about bromelain anti-pain and swelling activity the team at the University of Mosul College of Dentistry compared the effect of oral bromelain (4 × 250 mg) versus oral diclofenac sodium (4 × 25 mg) on pain, swelling, trismus, and quality of life (QOL) after surgical removal of impacted lower third molars.

The randomized, double-blind, placebo-controlled study included 45 patients requiring extraction under local anesthesia of a single partial bony impacted mandibular third molar randomly divided into 1 of 3 groups: bromelain, diclofenac, and placebo.

According to the results of the analysis, bromelain and diclofenac groups both showed a significant and similar reduction in pain compared with the placebo group at all intervals.

Both bromelain and diclofenac treatment groups also showed a significant difference in the effect on QOL in most subscales and total scores.

Dr. the lead scientist said, "The results of our study have shown that oral bromelain is an effective therapy to improve the QOL after surgical removal of impacted lower third molars, with an effect on the postoperative sequelae comparable to that of preemptive diclofenac sodium".

Taken together, bromelain may be considered supplements for the and treatment of pain and swelling, pending the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars by Singh T1, More V2, Fatima U3, Karpe T4, Aleem MA5, Prameela J. (PubMed)
(2) Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial by Majid OW1, Al-Mashhadani BA. (PubMed)

#Bilberry Extract (Mirtoselect) Exerts a Strong Anti #LiverCancer by Suppressing Cell Proliferation Activity, Researchers Say

Kyle J. Norton

Scientists may have found a herbal remedy for the treatment of liver cancer with no side effects, according to studies.
Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells' DNA which normally begin in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

If you experience some symptoms of the above, please make sure you check with your doctor to rule out the possibility of liver cancer.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to overexpression of the overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

There are a number of risk factors other than those mentioned above associated with the onset of liver cancer such as male, ethnicity, and hepatitis viral carriers.

However, most people with some of the above risk factors have never developed liver cancer.

Some researchers suggested that widespread obesity may be one of the major risk factors involved in the onset of the disease.

Dr. Aleksandrova K, the lead scientist in the article of obesity and liver cancer said, "Obesity and related metabolic disorders have become globally prevalent posing a challenge for the chronically damaged liver and predisposing the development and progression of cancer".

And, "Accumulating evidence has established an association between higher body mass index as an indicator of general obesity and a higher risk of primary liver cancer. The associations are stronger in men, in patients with underlying liver disease, and in white ethnic groups. Abdominal obesity, weight gain in adult life, and metabolic factors related to visceral fat accumulation were also suggested as important risk factors for liver cancer".

The results clearly suggested that if you are obese, your risk of liver cancer is increased substantially, compared to non-obese individuals.

Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Scientists on finding a natural ingredient for the treatment of liver cancer investigated the protective effect of bilberry extracts (BBE) and enzymatically modified isoquercitrin (EMIQ) on the hepatocarcinogenic process involving oxidative stress responses.

Rat selected to the study was injected to introduce the two-stage hepatocarcinogenesis in N-diethylnitrosamine-initiated and piperonyl butoxide (PBO).

Co-administration of BBE or EMIQ suppressed these effects with the reductions of GST-P(+) foci (area) to 48.9-49.4% and Ki-67(+) cells proliferation to 55.5-61.4% of the PBO-injected cases. Neither BBE nor EMIQ alone decreased microsomal reactive oxygen species induced by PBO.

Co-administration of BBE and EMIQ decreased the incidences of phosphor-PTEN (-) foci which play a critical role in enhancing malignant proliferation and invasion abilities of liver cancer cells, to 59.8-72.2%, and Smad4(-) foci to 62.4-71.5% in the promotion of liver cancer of the PBO-promoted cases.

Furthermore, injection also BBE also suppressed the incidence of phospho-Akt substrate(+) involved liver cancer cell survival to 75.2-75.7% of the PBO-promoted cases.

The finding strongly suggested that co-treatment with BBE or EMIQ suppressed cell proliferation activity of preneoplastic liver cells.

Additionally, in order to reveal more information about bilberry anti-liver cancer activity, researchers examined the anthocyanins' cancer chemopreventive properties in preclinical models.


In this study, anthocyanins and their metabolites were analyzed in the urine of two patients with colorectal liver metastases.

A single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra-operatively during liver, resection showed that there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum.

These results suggested that bilberry extract (mirtoselect) via nasojejunal tube intra-operatively exerted anti-liver cancer effects without reducing the expression of anthocyanins, as the stomach is the predominant site for anthocyanin absorption.

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of liver cancer, pending the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model by Hara S1, Morita R2, Ogawa T1, Segawa R1, Takimoto N1, Suzuki K3, Hamadate N4, Hayashi SM5, Odachi A6, Ogiwara I6, Shibusawa S7, Yoshida T1, Shibutani M. (PubMed)
(2) Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract by Cai H1, Thomasset SC, P-Berry D, Garcea G, Brown K, Steward WP, Gescher AJ. (PubMed)
(3) Obesity and Liver Cancer by Aleksandrova K1, Stelmach-Mardas M2,3, Schlesinger S. (PubMed)

#Honey Shows a Significant Effect on Diabetes, #HTN, #Dyslipidemia, Obesity and #CVD, Researchers Say

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of heart disease, according to studies.
Heart diseases are a medical condition associated with any disruption of blood vessels and heart function.

There are 5 types of heart diseases, including
* Heart disease affected by the arteries to the heart, such as coronary artery heart disease
* heart disease affected by heart valves function in regulating blood flow such as valvular heart disease
* heart disease affected electrical conduction such as arrhythmias
* Heart disease affected by heart muscles such as cardiomyopathy
and * Congenital heart disease caused by heart defect at birth


According to the statistics, heart disease is the leading cause of death in the US, approximately 610,000 people die of heart disease every year.

Coronary heart disease (CHD) kills over 370,000 people annually.

The most common heart disease in North America is CHD, the type of heart disease caused by plaque buildup on artery walls, leading to narrow, thickens, and stiffens arteries. Some researchers suggested that the causes of plaque buildup on the arterial wall were the results of several factors including an unhealthy diet, lack of exercise, being overweight, and smoking.

Dr. Sonia S. Anand and colleagues in examing the risk of heart disease associated with poor diet wrote, "Based on the current evidence, the optimal dietary pattern to reduce CVD is one that emphasizes whole grains, fruits and vegetables, legumes, nuts, fish, poultry, and moderate dairy and heart-healthy vegetable oil intake; this pattern will likely reduce the CVD risk by about a third".

And, "This healthy dietary pattern needs also to be low in refined grains, added sugars, trans-fats, SSBs, and red and processed meats. The traditional Mediterranean-type diet provides a well-tested prototype for this healthy dietary pattern".

Researchers not only mentioned that the Western diet pattern is associated with the risk of CVD indirectly but also suggested that the diet pattern including the intake of whole grains, fruits and vegetables, legumes, nuts, fish, poultry, and moderate dairy and heart-healthy vegetable oil in reducing the risk of CVD.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener many people.

Researchers on finding a natural compound for the treatment of heart disease investigated the
honey and its polyphenols' cardioprotective activity.

According to epidemiological studies, regular intake of phenolic compounds is associated with reducing the risk of heart disease.

Honey exerted coronary heart disease protective effects by the expression of phenolic compounds through several mechanisms, including mainly antithrombotic, anti-ischemic, anti-oxidant, and vasorelaxant effects.

Furthermore, the effect of flavonoids found in honey decreased the risk of coronary heart disease by improving coronary vasodilatation, decreasing the ability of platelets in the blood to clot, and preventing low-density lipoproteins (LDLs) from oxidization.


The results clearly suggested the preventive role of polyphenols in honey against the onset of cardiovascular diseases (CVD).

In order to reveal more information about the honey's cardioprotective activity, researchers examined the honey's effects on blood sugar, body weight, lipid profile, C-reactive protein, nitric oxide, proinflammatory prostaglandins, and homocysteine.

By examing the growing evidence and scientific data, researchers found honey not only demonstrates in the treatment of diabetes, HTN, dyslipidemia, and obesity but also has a potential effect against CVD.

Taken together, honey may be considered a functioning remedy for the prevention and treatment of heart disease, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) The Potential Role of Honey and its Polyphenols in Preventing Heart Diseases: A Review by M I Khalil and S A Sulaiman. (PubMed)
(2) Honey and cardiovascular risk factors, in normal individuals and in patients with diabetes mellitus or dyslipidemia by Al-Waili N1, Salom K, Al-Ghamdi A, Ansari MJ, Al-Waili A, Al-Waili T. (PubMed)
(3) Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system. A Report from the Workshop convened by the World Heart Federation by Sonia S. Anand,1,2,* Corinna Hawkes,3,* Russell J. de Souza,4 Andrew Mente,2Mahshid Dehghan,2 Rachel Nugent,5 Michael A. Zulyniak,1 Tony Weis,6 Adam M. Bernstein,7Ronald Krauss,8 Daan Kromhout,9 David J.A. Jenkins,10,11 Vasanti Malik,12Miguel A. Martinez-Gonzalez,13 Dariush Mozafarrian,14 Salim Yusuf,2 Walter C. Willett,12 andBarry M Popkin. (PMC)

#Beet Increases the Levels of #Antioxidants by Reducing the #OxidativeStress Triggered By Injury and Inflammation

Kyle J. Norton

Beet or beetroot may be considered a functional food in protecting the body against the onset of diseases caused by oxidative stress, some scientists suggested.
Oxidative stress is the result of the imbalance of the ratio of free radicals and antioxidants in the body.

In other words, it is caused either by overexpression of free radicals or depletion of antioxidant enzymes produced by the host body.

A free radical is an unstable molecule with unpaired electrons in the outer ring formed when oxygen interacts with certain molecules. The highly reactive radicals once formed can start a chain reaction, like dominoes that may not stop until they are inhibited by antioxidants.

According to the free radical theory, an organism's age and are sick are associated with the accumulation of free radicals that cause damage to the cells over time.

An antioxidant is a stable molecule that inhibits oxidation.

Long-term expression of oxidative stress in the body can induce aging and chronic diseases.

Dr. the lead author on the concerns of overexpression of free radicals in the risk of aging and illness launched an investigation to examine the negative effect of ROS on the risk of the depletion of antioxidant defenses.

The differentiation found that oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer).

There is a significant association between ox-LDL and higher arterial stiffness, independent of other traditional CVD risk factors, and link atherosclerosis with oxidized LDL-cholesterol (ox-LDL) as the compound mainly responsible for its production in the elderly.

In diabetes mellitus (type 1 and 2), there is an association between an increased formation of free radicals and decreased antioxidant potential, leading to macro- and microvascular complications.

And, oxidative stress plays a pivotal role in the progression of CKD, through glomerular damage and renal ischemia and, indirectly, with inflammation, hypertension, and endothelial dysfunction.


All these results found in the differentiation suggested that by identifying different types of oxidative stress biomarkers in the facilitation of chronic illness may provide important information about the efficacy of the type of treatment, and the guiding selection of the most effective drugs/dose regimens for patients.


Beet is best known as the beetroot or garden beet and belongs to the Amaranth family. It is a perennial plant with leafy stems growing to 1–2 m tall.

The widespread oxidative stress-related chronic diseases has been a burden to health care systems such as diabetes, cardiovascular disease, and cancer concern many scientists.

Particularly, the medication used for the treatment of these diseases has been found to induce a number of serious side effects.

Researchers at the Poznań University of Medical Sciences in the finding the natural ingredient which processes a potential for the treatment without inducing any adverse effects launched an evaluation to analyze the effect of beetroot juice against N-nitrosodimethylamine (NDEA)-induced liver injury.

In two hepatic cell lines: non-tumor THLE-2 and hepatoma-derived HepG2 cell lines, treatment with 2, 10, and 20 μm of BET resulted in the translocation of Nrf2 from the cytosol to the nucleus., thus inhibiting the Nrf2 function that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.

These initiation caused by beet juice was an application of accompanied by the phosphorylation of serine/threonine kinase (AKT) in the mediation of carcinogenesis, JNK (c-Jun N-terminal kinase) in the regulation of that regulates the biological processes implicated in tumorigenesis, and extracellular signal-regulated kinase (ERK) in the mediation of cancer cell stages of division.

Additionally, beet juice also increased the expression of antioxidants in the gastric cell lines through significantly increased the mRNA and protein levels of GSTP, GSTT, GSTM, and NQO1, the groups of protein which play an important role in cellular protection against oxidative stress and toxic foreign chemicals, in these cells.

Interestingly, BET did not modulate any of the other parameters measured in the HepG2 cells and did not change the methylation of GSTP1 in these cells either.

The finding led us to believe that BET through the activation of Nrf2 and subsequent induction of the expression of genes controlled by this factor may exert its hepatoprotective and anticarcinogenic effects.

In other words, BET increased the levels of antioxidants by reducing the oxidative stress triggered by injury and inflammation through the protection of cell DNA against cancer initiation and the liver against the expression of chemical toxins.

Taken altogether beet juice may be considered a functional liquid for the inhibition of oxidative stress and adjunct therapy for the treatment of oxidative stress-related diseases, depending on the confirmation of large sample size and multi-center study in human

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) What is NRF2?
(2) Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines by Krajka-Kuźniak V, Paluszczak J, Szaefer H, Baer-Dubowska W.(PubMed)

#Honey Processes A Direct Anti-Hangover Activity In a Dose Time-Dependent Manner, Scientists Reveal

Kyle J. Norton

The traditional medicine suggested that the intake of one spoonful of honey before and after a drinking party may prevent a hangover.
According to Dr. Zhou, a scientist in the field of TCM, honey processed cooling, hydrating, and revitalizing properties and has been used in traditional Chinese medicine for purifying stimulants and a tonic against dizziness and hangover-upset stomachs.

A hangover is unpleasant physiological and psychological effect caused by the (over) consumption of alcohol, according to studies.

Most common symptoms of a hangover include a headache, drowsiness, concentration problems, dizziness, fatigue, and gastrointestinal discomforts.


The exact causes of hangover are unknown. The most common factor associated with a hangover is the accumulation of acetaldehyde, a highly toxic substance.

The conversion of acetaldehyde is a chemical process as a result of enzyme alcohol dehydrogenase (ADH) which metabolizes the alcohol intake to acetaldehyde.

Depending on the individual variations in alcohol metabolism, some people may experience worse hangover symptoms than others.

Hangover symptoms are affected by alcohol tolerance which is measured by the bodily responses to the functional effects of ethanol in alcoholic beverages.

CYP2E1, one of the genes has been linked with alcohol tolerance. However, people with high alcohol tolerance are also more likely to develop alcoholism.

Dr. Claire Heit,, the lead scientist in the evaluation of the role of CYP2E1 in alcohol metabolism wrote, "Acetaldehyde (the direct metabolite of ethanol oxidation) contributes to many aspects of the behavioral effects of ethanol. Given acetaldehyde cannot pass through the blood-brain barrier, its concentration in the CNS is primarily determined by local production from ethanol".

And, "Catalase and cytochrome P450 2E1(CYP2E1) represent the major enzymes in the CNS that catalyze ethanol oxidation. CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions".

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Scientists on finding a natural and potential compound for hangover relief examined the traditional medicine use of honey for preventing drunkenness and relieving hangover symptoms.

Intoxicated male mice selected for the study were assigned randomly either to low or high doses of lychee flower honey (2.19 or 4.39 g/kg body weight, respectively) that were single orally administrated 30 min before the ethanol intoxication of mice, followed by recording the locomotor activity by autonomic activity instrument and observing the climbing ability after alcohol or 2.19 g/kg honey that was single orally administrated 5 min after the ethanol intoxication of mice, followed by determining the ethanol concentration in mice blood.

Both doses of honey increased the autonomic activity of alcoholized mice.

Futhermore, intoxicated mice treated with 2.19 g/kg honey showed a decrease significantly of blood ethanol concentration.

Additional differentiation suggested that The anti-intoxication activity of honey is attributed to the effect of the fructose contained in the honey.

Interestingly, honey inhibited hangover symptoms without affecting the levels of oxidative stress and antioxidant enzymes produced by the host.

The results showed that honey processed a direct anti-hangover activity in a dose time-dependent manner.

Taken altogether, honey may be considered a functional remedy to relieve hangover symptoms caused by alcoholic intoxication, pending the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Honey reduces blood alcohol concentration but not affects the level of serum MDA and GSH-Px activity in intoxicated male mice models by Shi P1,2, Chen B3, Chen C1, Xu J3, Shen Z1, Miao X4,5, Yao H. (PubMed)
(2) The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System
Claire Heit, Hongbin Dong,b Ying Chen, David C. Thompson,c Richard A. Deitrich,d and Vasilis Vasiliou. (PMC)
(3) Curing hangovers the Chinese way by Timeout

#Strawberries' #Extract Induces Cytotoxicity in Leukemia (CEM) Cells cancer cells, Through its Antioxidant Properties, Researchers Say

Kyle J. Norton

Scientists may have found a whole food that contains abundantly bioactive compounds for the prevention and treatment of leukemia with no side effects, some studies suggested.
Leukemia is a medical and chronic condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system or the body's blood-forming tissues.

Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

The causes of leukemia are unknown. However, the most common risk factors associated with the onset of the disease include radiation exposure, treatment chemotherapy for cancer, smoking, family history of leukemia, and exposure to certain chemicals such as benzene.

Genetic preposition, according to some researchers, also plays a critical role in the prevalent risk of leukemia.

Dr. Nazanin Heidari, the lead scientist in the investigation of the genetic impact on the risk of leukemia wrote, "Epigenetic and genetic alterations are two mechanisms participating in leukemia, which can inactivate genes involved in leukemia pathogenesis or progression".


The team continued, inactivation of the genes ASPP1, TP53, IKZF1, and P15, have been correlated with poor prognosis in acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML), respectively. And abnormal genes specifically involved in leukemogenesis such as chromosomal translocations as well as genetic or epigenetic alterations, are involved in leukemogenesis.

Therefore, people who carry the mutated or inactive genes are at an increased risk of the condition.

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. The fruits have been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin

On finding a natural ingredient or whole food for the prevention and treatment of leukemia (CEM), researchers at the Indian Institute of Science evaluated the consumption of berry fruits, including strawberries, against oxidative stress-mediated diseases.

In vivo, the methanolic extract of strawberry (MESB) fruits demonstrated a potential activity against leukemia (CEM) cell lines.

In mice models, the extract of the fruit also displayed cancer therapeutic and chemopreventive potential.

According to the tested assay, MESB induced cytotoxicity in cancer cells, irrespective of origin, through its antioxidant properties in a concentration- and time-dependent manner.


Furthermore, according to the results at the end of the experience, MESB treatment affected tumor cell proliferation by activating apoptosis with no side effects.

In-depth analysis of the effect of the extract, researchers found that MESB induces cancer cell apoptosis by enhancing the function of the tumor suppressor gene p70 in the intrinsic pathway of apoptosis bypassing the mutated tumor suppressor gene p53.

Dr. Somasagara RR, the lead author said, "Strawberry fruits possess both cancer preventive and therapeutic values".

Taken together, strawberries with abundant bioactive compounds may be considered a functional fruit for the prevention and treatment of leukemia (CEM) with no side effects.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis by Nazanin Heidari, M.Sc,1 Saeid Abroun, Ph.D.,Jessika Bertacchini, Ph.D,3 Tina Vosoughi, M.D,1 Fakher Rahim, Ph.D. and Najmaldin Saki, Ph.D. (PMC)