The #CrudeEthanolicExtract of #Ginger Exhibits Anti-#Cancer Activities In Vitros and Vivos, Researchers Say

Kyle J. Norton

Scientists may have found a kitchen spice that processes the potential to induce cancer cell death by cytotoxicity, according to studies.

Cytotoxicity is a process that stimulates the ability of certain chemicals or mediator cells to destroy living cells.

In herbal medicine, injection of plant extracts in some cases also induce cytotoxic effects to kill cancer cells without causing harm to nearby healthy cells through the protection of increased production of antioxidant enzymes.

In other words, the use of herbal medicine for the treatment of cancer can induce no side effects.

In cancer, the cytotoxic activity is carried out by the overexpression of reactive oxygen activity, leading to cancer cells apoptosis through a number of mechanisms, including cell death programming and cell cycle arrest proteins.


In healthy cells, the ROS cytotoxic activity can also cause significant damage to the proteins, lipids, and DNA, leading to the onset of chronic diseases, including cancer.


Some researchers suggested that activating the expression gene associated with tumor suppression to prevent the damage of healthy cells during the injection of chemo drugs may provide a necessary step for the prevention of chemo side effects in cancer patients.

Dr. Chit Fang Cheok, in the differentiation of protecting normal cells from the cytotoxicity of chemotherapy, wrote, "The occurrence of intolerable side effects in patients undergoing chemotherapy is still a major clinical hurdle. Finding tumor-specific therapy and exploiting the differences between normal cells and tumor cells has led to strategies targeting oncogenic mutations or the deficiency of tumor suppressor pathways in cancers".

And, "The concept requires the use of two drugs, the first to arrest the normal cells and the second, to kill only cycling (tumor) cells".

More interestingly, "several recent studies demonstrate that p53 activation protects normal cells from the toxicity of drugs acting in the S-phase or M-phase, including Ara-C,2 taxol,3 Aurora kinase inhibitors4, and Polo-like kinase inhibitors".


These results strongly suggested the model provided by herbal medicine may some days be used by conventional medicine for the treatment of cancer without causing severe side effects.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural ingredient for cancer treatment examined ginger's cytotoxic activity on cancer cells.

In vivo, researchers compared the anticancer effect of ginger in a total of 80 OV and nitrosamine (OV/ DMN)-induced CCA hamsters fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days vs control groups consisting of 10 hamsters for each group fed with 5-fluorouracil (positive control) or distilled water (untreated control).

Injection of crude ethanolic extracts of ginger at a dose of 10.95, 53.15, and 27.86 μg/ml with Median IC50 (concentration that inhibits cell growth by 50%) values exerted strong cytotoxicity and antioxidant activities.

The crude ethanolic extracts of ginger demonstrated a 7-9 fold in exhibited the function of genes associated with the transportation of the chemo drugs observed by the DNA fragments on the cancer cell line.

The extract also induces acute and subacute toxicity at the maximum 5,000 mg/kg body weight dose.

Furthermore, the injection displayed a strong effect on the survival time and survival rate of the CCA-bearing hamsters compared to the control group (median of 54 vs 17 weeks.

Dr. Plengsuriyakarn T, the lead scientist said, "Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity".

Moreover, in the examined ginger anti-cancer activity, researchers investigated the cytotoxic and antitumor activity of ginger essential oil (GEO).

GEO showed potent in vitro cytotoxic activity against DLA and EAC cell lines. The IC50 values for the DLA cell line and EAC cell line were 18 μg/ml. were found to be 11 μg/ml and 18 μg/ml, respectively.

However, on L929 cell lines and to Vero cells, The IC50 of GEO was found to be 41 μg/ml and ˃100 ug/ml, respectively, significantly higher compared to the DLA cell line and EAC cell line.

Additionally, treatment with GEO (500 mg/kg and 1000 mg/kg body weight) significantly reduced the volume of solid tumor development by 54.4% and 62.4% respectively and the lifespan was increased up to 50% in 1000 mg/kg b. wt GEO treated ascites tumor-induced animals.

The findings once again, reconfirm the cytotoxic and antitumor effects of ginger.

Taken altogether, ginger, the kitchen, and pungent spice may be considered a functional food for the prevention and combined with primary therapy for the treatment of cancer with no or little side effects, pending the validity of large sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Cytotoxicity, toxicity, and anticancer activity of Zingiber officinale Roscoe against cholangiocarcinoma by Plengsuriyakarn T1, Viyanant V, Eursitthichai V, Tesana S, Chaijaroenkul W, Itharat A, Na-Bangchang K. (PubMed)
(2) Antitumor and cytotoxic activity of ginger essential oil (Zingiber officinale roscoe) by Jeena Kottarapat, Vijayasteltar B Liju, R. Kuttan. (Research Gate)
(3) Protecting normal cells from the cytotoxicity of chemotherapy by Chit Fang Cheok. (PMC)

#Phytochemical Indole-3-carbinol (I3C), Exhibits the Genes Associated With #CervialCancer Suppression through Several Mechanisms

Kyle J. Norton

Indole-3-carbinol may be the next pharmaceutical ingredient for the prevention and treatment of cervical cancer with no side effects, some studies suggested.

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with an alternation of cell DNA.

Researchers do not know what causes cervical cancer. Neither they can explain that women with the same health condition, or family history, are susceptible to the disease while others do not.

Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. Most women with cervical cancer do not experience any symptoms at this stage.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, and increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the American Cancer Society, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients.

The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites.

Epidemiological also suggested HPV infection, sexual activity, smoking, and giving birth many times. Infection with the human immunodeficiency virus (HIV, a history of sexually transmitted infections (STIs), and long-term use of oral contraceptives are some prevalent risk factors for cervical cancer.

However, most women with some risk factors have never developed cervical cancer.

According to the statistic, the 5-year survival rate for women with invasive cervical cancer is 92%. and approximately, 46% of women with cervical cancer are diagnosed at an early stage.

To find a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers investigated the anticancer effect of I3C and its major acid-catalyzed condensation product diindolylmethane (DIM), against the human cervical cancer cell lines.

In vitro, both I3C and DIM caused the accumulation of DNA strand breaks and induction of apoptosis in three cervical cancer cell lines.

In C33A cervical cancer cells, DIM was more potent than I3C and faster acting.

I3C reduced the expression of a protein associated with cancer cell proliferation and survival in a time- and dose-dependent manner.

Futhermore, I3C also promoted the protein associated with the programming of cancer cell death.

Moreover, in Mice that express transgenes for human papillomavirus type 16 under a keratin 14 promoter (K14-HPV16 mice) induced cervical cancer by being given 17beta-estradiol chronically, researchers found that indole-3-carbinol (I3C) administered at physiological doses, would prevent cervical-vaginal cancer promoted by high amounts of estrogen.

Compared to mice fed a control diet with those fed a diet supplemented with 2000 ppm I3C, researchers surprisingly discovered that only 2 mice of 24 in the group fed the I3C-supplemented diet developed cervical cancer. I3C also reduced dysplasia in the nontransgenic mice.

Dr. Jin L after taking into account co and confounders said, " I3C is a useful preventive for cervical-vaginal cancer and, possibly, other cancers with a papillomavirus component."

Also, in a cervical cancer cell line, the application of 13C exhibited the genes associated with cancer suppression through several mechanisms, including cancer cell adhesion, spreading, and invasion.

These results reconfirmed the diminished PTEN expression during the progression from low-grade to high-grade cervical dysplasia in humans and in a mouse model for cervical cancer.

Taken together, Indole-3-carbinol (I3C) may be used for the prevention and treatment of cervical cancer with no side effects, pending to large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(4) Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium by Chen DZ1, Qi M, Auborn KJ, Carter TH. (PubMed)
(5) Indole-3-carbinol prevents cervical cancer in human papillomavirus type 16 (HPV16) transgenic mice by Jin L1, Qi M, Chen DZ, Anderson A, Yang GY, Arbeit JM, Auborn KJ. (PubMed)
(6) Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo by Qi M1, Anderson AE, Chen DZ, Sun S, Auborn KJ.(PubMed)

#Healthyfood #CorianderHoney (CH) Exhibited Antitumor Effect by Modulating the Cell-Mediated Immune Response and Immunoglobulin Levels, Researchers Say

Kyle J. Norton

Scientists may have found a natural alternative remedy that modulates the immune function to the needs of the body, according to studies.
The immune system through immune response protects our body against infectious organisms and the inflammatory process that lead to chronic infectious disease and cancers.

There are 2 types of immune disorders. If the immune system is underactive, patients may be easily infected by foreign pathogens, leading to chronic infectious disease and cancer.

On another hand, if the immune system is overactive, patients may experience autoimmune disease caused by the immune system mistakenly attacking the bodily tissues, leading to chronic inflammatory disease, such as rheumatoid arthritis (RA).

The immune system has evolved over thousands of years with an aim to protect the body more efficiently in adapting to the change of environment. However, these changes in some cases may lead us to certain risks.

For example, the development of chronic inflammatory disease is a result of the immune system which can not kill off all invaders in the acute phase of infection, leading to the adaptation of the change or the chronic low-grade inflammatory disease.


Although there are many factors associated with the onset of immune dysfunction, some researchers suggested that widespread obesity may be the most prevalent risk factor in the Western world.

Dr. Giridharan NV at the Indian Council of Medical Research concerned with the risk of immune dysfunction in obese said, "Altered immunity under the obese condition is well documented in studies involving animal models. For example, both, genetically leptin-deficient (Ob/ob mice) and leptin receptor-deficient obese animals (Db/db mice and fa/fa rats) demonstrate a global impairment in ex vivo immune function"

And, " Obese animal’s show marked thymic atrophy, lower splenic and circulating T cells, decrease in mitogen-stimulated lymphocyte proliferative capacity and cell-mediated cytotoxicity [11-20]. Obese animals exhibited impaired innate immunity in terms of reduction in number and function of dendritic cells [21], displayed diminished development, differentiation and cytotoxicity of NK cells [22]".


The findings clearly suggested the association of obesity in the elevated risk of immune dysfunction.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural compound that processes immune modulatory activity investigated the immune protective effect on jungle honey (JH) collected from timber and blossom by wild honey bees that live in the tropical forest of Nigeria.

Female C57BL/6 mice included in the study were injected with JH (1 mg/mouse/day, seven times intra-peritoneal).

After seven injections, according to the assays analysis of the peritoneal cells (PC) and Lewis Lung Carcinoma/2 (LL/2) cells, jungle honey demonstrated an increased PC cells number and the percent of Gr-1 surface antigen and the intensity of Gr-1 antigen expression compared to control mice.

The new cells population increased in the PC were neutrophils, a common type of white blood cells that fight off infections correlated to the decreased tumor incidence and weight in the honey treatment of the group.

The increased immune activity in the honey treatment mice was associated with the increase of the ratio of reactive oxygen species (ROS) in entering cytotoxic activity against the tumor expression in JH-injected mice.

The finding clearly suggested that JH inhibited tumors through the expression of neutrophils mediated by ROS cytotoxicity.

In order to reveal more information about the honey immune modulatory activity, researchers examined the immune status in mature mice bearing Ehrlich ascites carcinoma (EAC).

Injection of coriander honey (500 mg/kg) showed a decrease in tumor volume, packed cell volume, and viable cell count, but an increase in non-viable cell count and mean survival time thereby increasing the lifespan of EAC-bearing mice.

The efficacy of coriander honey (CH) was found to be associated with the increased production of levels of immunoglobulin M, G, and A which are glycoprotein molecules produced by plasma cells in response to an immunogen with function as antibodies and the proliferation of T cells.


Dr. Ahmed Hegazi, the lead scientist wrote in the final report, "Coriander honey exhibited antitumor effect by modulating the cell-mediated immune response and immunoglobulin levels, in EAC bearing mice".

Taken altogether, honey, including JH and CH may be considered a functional remedy in the modulatory immune function to the body needs with no side effects, pending the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Jungle Honey Enhances Immune Function and Antitumor Activity by Miki Fukuda,1 Kengo Kobayashi,1 Yuriko Hirono,1 Mayuko Miyagawa,1 Takahiro Ishida,1 Emenike C. Ejiogu,2 Masaharu Sawai,3 Kent E. Pinkerton,4 and Minoru Takeuch. (Hindawi)
(2) Influence of Honey on Immune Status in Mice-Bearing Ehrlich Carcinoma by Ahmed G Hegazi*, Eman H Abdel-Rahman, Fayrouz Abd-Allah and Amr M Abdou. (Journal of Clinical & Cellular Immunology)
(3) The Impact of Obesity on Immune Response to Infection and Vaccine: An Insight into Plausible Mechanisms by Prathibha Bandaru1, Hemalatha Rajkumar1 and Giridharan Nappanveettil. (Endocrinology & Metabolic Syndrome)

Chinese #Artichoke Inhibits Learning and Memory Dysfunction Associated with Vascular Dementia or Alzheimer's disease, Researchers Say

Kyle J. Norton

Learning is an action of acquired skill or knowledge in a short or lifelong process.
Memory is an act of storing the acquired knowledge expressed when they are needed.

In other words, the learning and memory process involved different stages including acquisition, consolidation, and retrieval.

There are many causes of neuron loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes.

Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.

Toxins-induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.

Environmental pollutants, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.

Although the increase in aging has been well known to be a major factor in the initiation of learning and memory impairment in patients with neurodegenerative disease, the genetic mutation also has a strong implication on cognitive functions that can lead to either impairment in learning or memory.

Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation in patients with learning and memory impairment, said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".

"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats was stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".

The findings strongly suggested that gene alternation due to long-term exposure to toxic chemical cause gradual loss and death of neurons, leading to learning and memory impairment.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.

Ginkgo biloba leaf extract (ginkgo extract) is used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.

Oral administration of choro gi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.

Furthermore, both choro gi and ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.

In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide and was significantly suppressed by choro gi extract and ginkgo extract.

These results suggested choro gi or ginkgo extract protected the neuron's integrity and viability by inhibiting the overexpression of free radicals by improving the antioxidant enzymes produced by the mice.

Researchers in the final report wrote. "choro gi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".

Taken together, artichokes may be considered a functional remedy for preventing and treating p learning and memory impairment with no side effects, pending the validation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)

#Malvidin Found in #Herbal #Bilberry Extract Processes Anti-#ColonCancer Properties by Repressing #Cancercell Proliferation, According to Researchers

Kyle J. Norton

Colon cancer is a medical and chronic condition characterized by the growth of cells disorderly and uncontrollably in the colon tissue.
Most cases of colon cancers begin in the cells on the surface of the inner lining due to the alternation of DNA.

Colon cancer is one most slow groslow-growingwing cancer. It may take years before patients experience the symptoms.

At the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized severe pain and bleeding.

The most common symptoms of colon cancer in the advanced stage, besides the general symptom of cancer such as reduced appetite, and unintended weight loss include a change of bowel movement, rectal bleeding, and persistent abdominal pain and cramp.

If you experience some of the above symptoms, please check with your doctor to rule out the possibility of colon cancer.

According to the statistics, in 2017, approximately 26,800 Canadians were diagnosed with colorectal cancer, representing 13% of all new cancer cases.

Depending on the stage, early diagnosis of localized colon cancer has a 5-year relative survival rate of over 90%.

Out of a number of the risk factors, obesity may be one which causes the majority of colon cancer in the Western world, particularly in North America.

Dr. E E Frezza, the lead scientist in the assessment of obesity on the risk of developing colon cancer, said, "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".

And, "Obesity imposes a greater risk of colon cancer for men of all ages and for premenopausal women than it does for postmenopausal women. Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. We believe that a combination of waist circumference (WC) and body mass index (BMI) measurements is recommended to assess the obesity-related risk of developing colon cancer".


The results suggested that if you are obese, your risk of colon cancer is increased much fold compared to healthy-weight individuals.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of colon cancer examined the bilberry-derived Anthocyanin's chemopreventive properties.

The study included 50 female Balb/c mice induced colonic carcinogenesis by AOM and DSS 3 or 5%, respectively, Mice then are given either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract.

According to the colonoscopy taken place at weeks 4 and 9 after initiation of carcinogenesis, mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation.

Furthermore, mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumor numbers, compared to control (n = 14) and anthocyanin 1% treated mice.

The results suggested that anthocyanins inhibited the formation and growth of colorectal cancer in an animal model.
anthocyanins'
In order to reveal more information about anthocyanins anti-colon cancer activity, researchers examined the compound on human colon and colorectal cancer cells (DLD-1 and COLO205).

Using the optimum process of A(V.uli) extraction involved conditions of temperature 20°C, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. A(V.uli), 5 main components: delphinidin (40.70 ± 1.72)%, cyanidin (3.40 ± 0.68)%, petunidin (17.70 ± 0.54)%, peonidin (2.90 ± 0.63)% and malvidin (35.50 ± 1.11)% were found in the anthocyanins extract.

Malvidin, the derivatives found in the extracts exerted the strongest anti-colon cancer cell properties with dose-dependent repression of cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml, compared to other derivatives.

Dr. Zu XY and colleagues wrote in the final report, "The extraction protocol and conditions we used were effective for anthocyanin extraction. A(V.uli) could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers".

Taken altogether, bilberry-processed abundantly bioactive compounds anthocyanin and malvidin may be considered a functional remedy for the prevention and treatment of colon cancer, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model by Lippert E1, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. (PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)

#Curcumin Found in #Turmeric Decreases the Levels of Hyperlipidemia by Reducing Body Weight, Liver Weight & Adipose Weight, Researchers Say

Kyle J. Norton

Hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.
The condition is normally known as high blood cholesterol in the general population.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances forms plaque, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

Believe it or not, about half of U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol.

There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, overweight gain, physical activity, and smoking.

Some researchers suggested the promotion of a high-fat diet over past decades may be one of the silent causes of hyperlipidemia in the Western world.

Dr. Charles Desmarchelier in the examined the risk of high blood cholesterol in a high-fat diet model said, "Mice on Western diet showed increased plasma cholesterol levels, associated with the higher dietary cholesterol supply, yet, significantly reduced cholesterol levels were found in intestine and liver".

And, "(The) intestine and liver react to a high dietary fat intake by activation of de novo cholesterol synthesis and other cholesterol-saving mechanisms, as well as with major changes in phospholipid metabolism, to accommodate to the fat load'.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural ingredient for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.

The study included 40 male Wistar rats divided into four groups with 10 rats in each. Two groups were fed with a standard rodent diet and the other two with a 60% high-fructose diet for 10 weeks. Curcumin (200 mg/kg body weight) was administered along with the diets simultaneously to each of the aforementioned diet groups.

After 10 weeks of the experiment, researchers found that curcumin decreased the levels of hyperlipidemia observed by reducing body weight, liver weight, and adipose weight.

The plasma levels of triglyceride inhibited the proteins associated with fat cell fat metabolism and lipid ratios and increased HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats were also lower by the injection of curcumin.

Furthermore, curcumin also suppressed the lipogenic enzymes involved in regulating lipogenesis in fat cells.

Taken together, turmeric processed high amount of curcumin may be used for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Highly bioavailable micellar curcuminoids accumulate in the blood, are safe, and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals by Kocher A1, Bohnert L1, Schiborr C1, Frank J, (PubMed)
(3) C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite plasma hypercholesterolemia by Charles Desmarchelier,1 Christoph Dahlhoff,1,2 Sylvia Keller,3 Manuela Sailer,1Gerhard Jahreis,3 and Hannelore Daniel. (PMC)

Dietary #Sinigrin Inhibits #LungCancer Proliferation Through Some Unknown Mechanisms, Researchers Find

Kyle J. Norton

Lung cancer is a chronic condition characterized by cell growth disorderly in the tissue of the lungs.
According to the statistic provided by the American Cancer Society, lung cancer is the leading cause of cancer death among both men and women. More people die of lung cancer than from colon, breast, and prostate cancers combined each year in the US.

In 2018, in the US 234,030 new cases of lung cancer were diagnosed in the US including 121,680 in men and 112,350 in women.

Most cases of lung cancer are diagnosed in people who are 65 or older. The lifetime risk of lung cancer in men is 1/15 and in women 1/17.

Certain risk factors such as long-term smoking, exposure to second-hand smoke, radon gas, and toxic chemicals, and family history are associated with the onset of lung cancer.

However, most people with some of the above risk factors do not develop lung cancer.

Some researchers suggested people with a weakened immune system such as the elderly, long-term use of antibiotics and immune suppressive medicine may be prone to getting lung cancer.

Dr. Joanna Domagala-Kulawik, in the examination of the role of the immune system in non-small cell lung carcinoma, wrote, "Very low and heterogonous antigenicity of lung cancer cells leads to passive escape from the anti-cancer immune defense. The cytotoxic lymphocytes (CTLs) that play a main role in the anticancer response are actively suppressed in the tumor environment and following regulatory mechanisms inhibit the recognition of tumor antigens by antigen-presenting cells".

The results clearly suggested that immune cytotoxicity against cancer cells is suppressed in patients with lung cancer. In other words, by restoring the genes associated with programming cancer cell death and tumor suppression, lung cancer may be preventable.


Sinigrin is a phytochemical glucosinolate, that belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on the finding a natural ingredient for the treatment of lung cancer examined the effects of dietary sinigrin or indole-3-carbinol on tumorigenicity in F344 rats.

During the experiment, dietary sinigrin at a concentration of 3 mumol/g diet decreased 7-methylguanine formation in hepatic DNA but had no effect on 7-methylguanine levels of lung or nasal mucosa DNA.

No effects on O6-methylguanine-DNA-transmethylase activity were observed in tissue extracts derived from the livers, lungs, and nasal mucosae of rats fed diets containing sinigrin or I3C.

Where O6-methylguanine--DNA-trans methylase activity is a DNA repair protein.

The findings strongly suggested that dietary sinigrin or indole-3-carbinol do not inhibit lung cancer expression through DNA repair.

However, dietary sinigrin plus nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco cancer-induced chemical resulted in a significant incidence of lung and nasal cavity tumors in F344 rats.

These results clearly suggested that dietary sinigrin inhibits lung cancer proliferation through some unknown mechanisms other than DNA methylation and O6-methylguanine repair.

Taken together, sinigrin may be used as a supplement for the prevention of lung cancer and combined with primary therapy for the treatment of lung cancer, pending to the confirmation of a large sample size and multicenter study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats by Morse MA1, Wang CX, Amin SG, Hecht SS, Chung FL. (PubMed)
(2) The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention by Joanna Domagala-Kulawik. (PMC)