#Honey with Different MGO Concentrations in the Promotion of Gastrointestinal Digestion, Researchers Say

Kyle J. Norton

Digestion is a process of the digestive system by breaking out food after intake of nutrients through mechanical and enzymatic action.

Indigestion, on the other hand, is symptom of another digestive disease, including GERD. Most cases of indigestion not caused by underlying diseases can be resolved quickly.

People with indigestion experience symptoms differently. Some may feel the symptoms of occasionally while others may feel them often and daily.

There are a number of risk factors associated with digestive disorders including bacterial and/or viral infection, inflammation, lactase deficiency, anti-inflammatory drugs, and certain conditions such as ruptured or perforated organs, muscle dysfunction, and gallstones.

However, some researchers suggested that there is a strong correlation between the risk of digestive disorders in obese patients.

Dr. Su Youn Nam, in the investigation of obesity-related digestive diseases, wrote, "Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett’s esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer".

And, "Although obesity-related esophageal diseases are associated with altered mechanical and humoral factors, other obesity-related digestive diseases seem to be associated with obesity-induced altered circulating levels of adipocytokines and insulin resistance".

The findings strongly indicated the risk of digestive disorders in obese is substantially higher compared to healthy-weight individuals.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Scientists on the finding of a natural ingredient for the treatment of gastroduodenal (GDD) digestions examined the effect of Manuka honey's antibacterial activity on tested strains.

In vitro, methylglyoxal (MGO), a bioactive found in Manuka honey injection showed a strong antibacterial activity at concentrations higher than those registered in digested MH samples.

The findings suggested that there must be some other compounds in the Manuka honey which also process the antibacterial property.

In fact, according to the tested assays in the modification of the chemicals occurring from digestion, the content of aromatic compounds, such as leptosin and methyl syringate played a critical role in increasing the levels of acetic and lactic acids in gastroduodenal digestion.

The results suggested that Manuka honey promoted gastroduodenal digestion through a number of metabolites.

In order to provide more information about Manuka honey in the promotion of digestion, researchers investigated its effects on gastrointestinal infection diseases and upper gastrointestinal dyspepsia.

The study included several commercial MH samples, with different MGO concentrations.

According to the tested assays, after digestion, MGO concentration decreases because it reacts with digestive enzymes by carbonylating their free amino groups in stimulating the gastric phase of digestion.

And other compounds in Manuka honey such as pepsin and pancreatin do not influence the digestion process.

In other words, methylglyoxal (MGO) promotes gastrointestinal digestion through its pronounced antibacterial potency.

Taken together, Manuka honey processed with a bioactive compound MGO may be considered a natural remedy for improvement of digestion, pending the validation of a larger sample size and multicenter human study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antistaphylococcal activity and metabolite profiling of manuka honey(Leptospermum scoparium L.) after in vitro simulated digestion by Mannina L1, Sobolev AP2, Coppo E3, Di Lorenzo A4, Nabavi SM5, Marchese A3, Daglia M. (PubMed)
(2) Influence of in vitro simulated gastroduodenal digestion on methylglyoxal concentration of Manuka ( Lectospermum scoparium ) honey by Daglia M1, Ferrari D, Collina S, Curti V. (PubMed)

#Tomato Protects Diabetics Against Complications Caused by Abnormally High Levels of High Blood Glucose and Lipid

Kyle J. Norton

Oxidative stress is an imbalanced ratio of free radicals and antioxidant enzymes produced by the host.
In other words, diseases associated with oxidative stress such as cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer are results of the prolonged period of overexpression of free radicals compared to reduced levels of antioxidants.

Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order to become stable, free radicals readily steal or donate an electron from other molecules, leading to a free radical cascade that cannot be stopped until all outer ring electrons are paired or inhibited by antioxidants.

Antioxidants are stable molecules that inhibit oxidation.

Diabetes is a chronic condition of insufficient insulin entering the bloodstream, caused either by the gradual died-off of the beta cells in the pancreas or insulin receptors clogged up by cholesterol.

In our body, free radicals induced by cell metabolism for the body to function normally are inhibited by the antioxidant either produced by the body or the intake of antioxidant chemical compounds from dietary sources.

Free radicals can enter our body from environmental factors, such as the air we breathe, and the foods we eat.

Some researchers suggested that the reduced levels of antioxidants against the overexpression of free radicals most likely occurred in people with a weakened immune system such as the elderly due to aging.

Dr. Viviana I Pérez, the lead scientist said, "Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level".


And, "While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging".


Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural compound for the treatment of diabetes with no side effects, researchers examined the beneficial effect of tomatoes in diabetics.

Participants in a type-II diabetic group (n=40) and age-matched control group (n=50 are included in the study.

Before treatment, the type-II diabetic group showed significantly lower levels of antioxidant enzymes and a very high lipid peroxidation rate compared to the control group.

According to the analysis of the short-term supplementation, tomatoes (cooked) showed a significant improvement in antioxidant enzyme levels and decreased lipid peroxidation rate in the diabetic group for a period of 30 days.

Once again, in a total of 90 subjects including a type 2 diabetic group (n = 40) and an age-matched control group (n = 50), researchers once against investigated the anti-diabetes activity of lycopene.

Patients with type 2 diabetes have significantly lower levels of antioxidant enzymes and very high lipid peroxidation, as well as higher levels of lipid profile and glycated hemoglobin (HbA1c), compared to controls before the application of lycopene.

Long-term tomato supplementation in diabetes mellitus showed a significant improvement in the levels of antioxidant enzymes and decreased lipid peroxidation rate (p < 0.001), with no effect on lipid profile and glycated hemoglobin HbA1c levels.

In other words, long-term tomato injection protects diabetics against complications associated with abnormally high levels of high blood glucose and lipid, through its antioxidant activity.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of short term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type-II diabetes by Subhash K1, Bose C, Agrawal BK. (PubMed)
(2) Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated hemoglobin in Type 2 diabetes mellitus by Bose KS1, Agrawal BK. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)

#Healthyfood #Gingers Attenuate the Day-to-Day Progression of #MusclePain

Kyle J. Norton

Muscle pain is the condition of pain originating from the muscle. Muscle pain may be caused by injury or overexertion, infections of soft tissues, or inflammatory conditions.
Systemic muscle pain is the pain throughout the body, often induced by an infection, an illness, or a side effect of long-term intake of certain medications, such as cholesterol medications.

There are many risk factors associated with muscle pain, including
1. Physical activity (PA) that requires the intensity, duration, and repetitiveness of muscular activity.

2. Occupations often involving static load, repetitive movements, and high peak forces, occurring for a prolonged duration are also some risk factors that causally relate to muscle pain development.

3. Overtraining in physical exercise.

Most muscle pains can be treated with over counter painkillers. If you are currently taking them for the treatment of muscle pain, please make sure you know all the side effects for preventive measures.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of muscle pain quickly examined the effects of 11 days of raw (study 1) and heat-treated (study 2) ginger supplementation on muscle pain.

Study 1 and 2 were identical double-blind, placebo-controlled, randomized experiments with 34 and 40 volunteers, respectively

Also, participants consumed 2 grams of either raw (study 1) or heated (study 2) ginger or placebo for 11 consecutive days and participants performed 18 eccentric actions of the elbow flexors to induce pain and inflammation.

According to the assays, ginger showed a significant pain reduction in 24 hours after eccentric exercise compared to a placebo.

There was no significant difference between both types of ginger and placebo on other measures.

Daily supplementation with ginger reduced muscle pain caused by eccentric exercise, and this effect was not enhanced by heat-treating ginger.


Dr. and colleagues wrote, "Daily consumption of raw and heat-treated ginger resulted in moderate-to-large reductions in muscle pain following exercise-induced muscle injury".


In order to reveal additional information about ginger in treating muscle pain, researchers evaluated the acute effects of ginger on muscle pain, inflammation, and dysfunction induced by eccentric exercise.

The double-blind, cross-over design, included 27 participants who performed 24 eccentric actions of the non-dominant elbow flexors and ingested a 2 g dose of ginger or placebo 24 h and 48 h after exercise.

Before ginger treatment, eccentric exercise caused moderate arm pain (39 ± 20 mm; mean ± SD) and dysfunction (14% decrease in ROM), and an increase in volume (1.8%).

Ginger consumption demonstrated no effect on muscle pain, dysfunction, or metabolic rate compared with a placebo before 24 hours.

However, after 24 hours, arm pain was reduced (13%, -5.9 ± 8.8 mm) the following day, 48 h after exercise.

Based on the finding, researchers said, "a single 2 g dose of ginger does not attenuate eccentric exercise-induced muscle pain, inflammation or dysfunction 45 min after ingestion. However, ginger may attenuate the day-to-day progression of muscle pain".

Taken together, ginger may be considered a functional alternative for the treatment of muscle pain after 24 hours, pending the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise by Black CD1, Herring MP, Hurley DJ, O'Connor PJ. (PubMed)
(2) Acute effects of dietary ginger on muscle pain induced by eccentric exercise by Black CD1, O'Connor PJ. (PubMed)
(3) Physical Activity as Cause and Cure of Muscular Pain: Evidence of Underlying Mechanisms by Karen Søgaard and Gisela Sjøgaard. (PMC)

#Alliin Exerts Myocardial Protection by Increasing the Heart's Ability to Withstand the Ischaemic Insult, According to Researchers

Kyle J. Norton

Myocardial ischemia injury is a medical condition caused by severe impairment of coronary blood supply-induced damage or dysfunction of the cardiac tissue.

Myocardial reperfusion is the process to restore the coronary blood flow after a period of coronary blockage that leads to severely reduced or no oxygen .blood flow to the heart.

The condition severity is totally dependent on the intensity and duration of the coronary occlusion.

According to the statistics from the WHO, in 2008, 12% of all death or approximately 7,254,000 deaths worldwide have directly or indirectly caused by myocardial ischemia injury.

In other words, coronary heart disease causes 1/4 of total death in the worldwide population and 50% of the death associated with other forms of heart disease.

Most common symptoms of myocardial ischemia injury are neck or jaw pain, shoulder or arm pain, a fast heartbeat, shortness of breath, and fatigue accompanied by nausea and vomiting.

Most common causes of myocardial ischemia injury are a result of the plaque built-up on the coronary arterial wall due to long-term unhealthy diet with higher amount of fat and trans fat, red meat, processed food and fewer in fruits and vegetables.

Most patients with CHD also are found to have a sedentary lifestyle.

In other words, the promotion of a high-fat diet over the past few decades induced obesity is the major culprit that celebrates the risk of myocardial ischemic injury.

Dr. Meng F, the lead scientist wrote, "Obese patients are more sensitive to myocardial ischemia, which has been linked with high mortality rates".

And "(High fat diet-induced)An impaired MIF/AMPK activation response (cellular stress response) and consequently reduced membrane Glut4 expression (in the heart muscle) may play an important role in increasing myocardial susceptibility to I/R in obesity".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the prevention of the tissue damage caused by blood supply returns to tissue, researchers examined the role of alliin in myocardial ischemia-reperfusion (I/R) injury.

In a mouse model of I/R injury, injection alliin showed a significant effect in reducing the area at risk and the infarct area.

Compared with I/R group, alliin also improved the cardiac function in the mice I/R + alliin group. The expression of hypoxia/reoxygenation (H/R) induced apoptosis of cardiomyocytes due to I/R was also attenuated by the administration of alliin.

Confirmed by the tested assays, alliin also exerted the myocardial protection by increasing the heart's ability to withstand the ischaemic insult.

In vivo, alliin decreased cells apoptosis and increased the autophagy activity against the initiation of tissues damage after I/R injury in the tested animal.

Moreover, injection of 3-Methyladenine autophagy inhibitor commonly used to selectively block autophagy was found to reduce the function of alliin observed in the tested animal.
Based on the findings, researchers said, "All the results indicated that alliin alleviates myocardial ischemia-reperfusion injury by promoting autophagy".


Taken altogether, alliin may be considered a supplement for the protection against myocardial ischemia-reperfusion injury, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin alleviates myocardial ischemia-reperfusion injury by promoting autophagy by Zhao R1, Xie E1, Yang X2, Gong B. (PubMed)
(2) Impaired myocardial MIF/AMPK activation aggravates myocardial ischemia reperfusion injury in high-fat diet-induced obesity by Meng F1, Li D2, Song B3, Li L. (PubMed)

#Yoga Intervention Inhibits All Parameters Associated with the Risk of #CardiovascularDisease, Clinical Trials Suggest

Kyle J. Norton

The risk of cardiovascular disease is reduced substantially for people engaging in yoga practice regularly, a recent study suggested.

Cardiovascular disease is a medical condition referred to as heart attack, chest pain (angina), or stroke..... caused by narrowed or blocked blood vessels.

Yoga, the ancient technique for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well known to people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes research and supported by health advocates.

In a total of 554 subjects screened and 386 subjects (252 females) included in the analysis, short-term yoga-based intervention showed a significant improvement in 10-year cardiovascular risk (p < 0.001) with a strong positive correlation between CVD and serum total cholesterol (r = 0.60; p < 0.001).

The study also found that the correlation of cardiovascular disease risk factors is associated with the improvement of low-density lipoprotein cholesterol, triglycerides, serum very-low-density lipoprotein cholesterol, and systolic blood pressure in yoga participants.

Dr. Yadav R, the lead author said, "yoga-based lifestyle intervention program significantly reduced the CVD risk, as shown by lowered FRS and estimated 10-year CVD risk".

Furthermore, in the review of the literature found in databases of MEDLINE, EMBASE, CINAHL, PsycINFO, and The Cochrane Central Register of Controlled Trials, Out of 1404 records, 37 RCTs included in the systematic review and 32 in the meta-analysis selected, researchers indicated that yoga attendees showed a significant in reduced risk of cardiovascular diseases through improvement for body mass index, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. weight loss, decreased diastolic blood pressure, total cholesterol, triglycerides, and heart rate.

The study also found no significant difference between yoga and exercise, except for smokers, in the improvement of cardio health in yoga participants.

Collectively, according to Dr. Cramer H, the efficacy of yoga in reduced cardio risk factors revealed evidence for clinical treatment as an ancillary intervention for the general population and patients with a higher risk of cardiovascular disease, particularly for people with type 2 diabetes mellitus.

Taken together, the clinical efficiency of yoga in reducing the risk of heart disease is associated with many risk factors, such as weight, cholesterol, and blood pressure...... people should only attend classes tailored to their needs.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Framingham Risk Score and Estimated 10-Year Cardiovascular Disease Risk Reduction by a Short-Term Yoga-Based Life-Style Intervention by Yadav R1, Yadav RK1, Sarvottam K1, Netam R1.(PubMed)
(2) The effectiveness of yoga in modifying risk factors for cardiovascular disease and metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials by Chu P1, Gotink RA2, Yeh GY3, Goldie SJ4, Hunink MG5.(PubMed)
(3) Effects of yoga on cardiovascular disease risk factors: a systematic review and meta-analysis by Cramer H1, Lauche R2, Haller H2, Steckhan N3, Michalsen A4, Dobos G2. (PubMed)

#Betacyanins Inhibit the Onset of #LiverSteatosis Through Their Antioxidant Activities in Vivos, Researchers Find

Kyle J. Norton

The liver is the largest internal organ that not only filters the blood coming from the intestinal system but also protects our body against chemical and drug toxicity.
Additionally, the liver also produces cholesterol that plays an essential role to aid digestion, producing vitamin D and steroid hormones, and building strong cell membranes.

Believe it or not, the liver also produces antioxidant enzymes that inhibit free radical oxidation and interact with the hormone insulin to store glucose in the form of glycogen.

Hepatic steatosis is a condition caused by the accumulation of fat in the liver. Liver steatosis can be classified into 2 types
* Alcoholic liver steatosis is caused by over-consumption of alcohol over time.

* Non-Alcohol Steatosis (NASH) is a condition of accumulation of excess fat in the liver in people who drink little or no alcohol. ... Non-Alcohol Steatosis is considered a major cause of liver scarring and cirrhosis.

The most common symptoms of liver steatosis are jaundice, abdominal swelling (ascites), enlarged blood vessels just beneath the skin's surface, enlarged breasts in men, enlarged spleen, and red palms.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

Conventionally, there is no effective treatment for liver steatosis. Weight loss and weight management through a combination of a healthy diet and exercise are the most recommended.

Some researchers suggested that the rise of liver steatosis in the US may be correlated to the promotion of a high-fat diet over the past few decades.

Dr. Arisqueta L, the lead scientist wrote, "High-fat diet (HFD) feeding or leptin-deficient mice are extensively used as models resembling features of human nonalcoholic fatty liver disease (NAFLD)".


And, "The concurrence of experimental factors as fat content and source or total caloric intake leads to prominent differences in the development of the hepatic steatosis and related disturbances".

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment for the prevention and treatment of liver steatosis, researchers examined whether betanin (from natural pigments, a member of betacyanins) had anti-oxidant properties against paraquat-induced liver injury in Sprague-Dawley rats.

Paraquat was injected intraperitoneally into rats to induce liver toxicity and randomly assigned to 4 groups: a control group, a paraquat group, and two groups received betanin at doses of 25 and 100mg/kg/day three days before and two days after administered paraquat.

Administration of betanin inhibited the elevated serum aspartate aminotransferase and alanine aminotransferase levels of the paraquat rats.

Betanin treated group also enhanced the production of antioxidant enzymes that counter the overexpression of free radicals-induced oxidative stress.

Furthermore, the betanin treated group also increased the expression of an enzyme associated with detoxification.

Moreover, liver mitochondrial damage caused by paraquat injection also was reduced by the administration of betanin.

In other words, all parameters associated with the onset of liver damage that causes steatosis to develop were decreased substantially in the animals treated with betanin than in those who received paraquat alone.

Based on the results, researchers after taking other factors into account wrote, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".

Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending the confirmation of a larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Red pitaya betacyanins protect from diet-induced obesity, liver steatosis, and insulin resistance in association with modulation of gut microbiota in mice by Song H1,2, Chu Q1, Yan F1, Yang Y1, Han W1, Zheng X. (PubMed)
(2) White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet-Induced Obese Mice by Song H1,2, Zheng Z1, Wu J1, Lai J1, Chu Q1, Zheng X. (PubMed)
(3) High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice by Arisqueta L1, Navarro-Imaz H2, Labiano I3, Rueda Y2, Fresnedo O. (PubMed)

The #Ginger-Containing Formula Wendan Decoction (WDD)Effects on Gastroesophageal Reflux Disease (#GERD) and Gastrointestinal (GI) Disorders, According to Studies

Kyle J. Norton

Gastroesophageal reflux disease (GERD) is a digestive disorder caused by the relaxation of the low end of the esophageal sphincter muscle which connects with the stomach at the wrong times, leading to the return of the stomach's contents back up into the esophagus.

Under normal digestion, the lower esophageal sphincter (LES) is closed after opening to allow food to pass into the stomach.

People with GERD may have symptoms of heartburn, a burning sensation in their chest usually after eating, chest pain, and regurgitation of food or acid liquid.

In serious cases, patients may experience symptoms of difficulty swallowing.

Most cases of GERD symptoms can be managed by lifestyle changes and over-the-counter medications. However, some people may need surgery to ease symptoms.

Unmanaged GERD has been found to damage the esophageal tissue and dysfunctional valve at the top of the stomach and bottom of the esophagus in some patients.

The exact causes of GERD are unidentified. Being overweight and obese, intake of certain medications, being a smoker, and being exposed to second-hand smoke are some factors associated with the prevalent risk of the condition.

Out of many risk factors, some researchers suggested aging may be a common risk of GERD in the elderly.

Dr. David A. Johnson, said, "The prevalence of erosive esophagitis and other complications of gastroesophageal reflux disease increases with age. Additionally, among all people with GERD, older adults are more likely to suffer severe complications, such as Barrett esophagus and esophageal carcinoma, than are younger people".

And, "Older age was associated independently with increasing acid exposure (P<0.0001), decreases in intra-abdominal LES length (P<0.001), increases in esophageal dysmotility, and increasingly ineffective peristalsis".


In the urgency to find a natural compound for the treatment of gastroesophageal reflux disease (GERD) and bile reflux gastritis (BRG) which are common gastrointestinal (GI) disorders with unmet medical needs, researchers evaluated the ginger-containing formula Wendan decoction (WDD) targets homeostatic disturbances.

The Wendan decoction (WDD) has been used for thousands of years in traditional Chinese medicine for the treatment of syndromes characterized by "reflux" and "gut-juice exposure" problems.

After reviewing medical data online, 33 studies involving 3253 participants (1351 vs. 1035 of the BRG in 20 publications, 449 vs. 418 of the GERD in 13 studies, and 194 vs. 159 of relapse rate in 6 trials) were selected.

According to the pooled data, the application of WDD showed a consistent therapeutic efficacy on BRG (OR = 6.00, 95%C = 4.68-7.69) and GERD (OR = 4.39, 95%CI = 2.72-7.07).

The relapse rate was 12.4% for WDD which is significantly lower than 44.0% in the conventional therapies (OR = 0.14, 95%CI = 0.08-0.26).

After taking into account co and confounders, researchers wrote in the final report, "The consistent therapeutic efficacy of the single TCM formula on GERD and BRD indirectly indicates reflux as common pathogenesis in reflux-associated GI disorders".

Taken together, WDD may be considered the functional alternative for the treatment of GERD and BRD, pending the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders by Ling W1, Huang Y1,2, Xu JH1,3, Li Y1,4, Huang YM1, Ling HB1,5, Sui Y6, Zhao HL. (PubMed)
(2) GERD and Aging by David A. Johnson, MD reviewing Lee J et al. Clin Gastroenterol Hepatol 2007 Dec. (NEJM Journal Watch)