By Kyle J. Norton
Parkinson's disease (PD) is a chronic medical condition that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.
In other words, Parkinson's disease is a progressive central nervous system disorder that affects neurons in transmitting messages in controlling movement.
Some patients in the very early stage of PD may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.
Researchers do not know why the neurons in the brain in some people are susceptible to gradually breaking down or dying while others do not even if they have similar health conditions and are from the same family.
However, they do know, according to the epidemiological study, aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the risk factors found in patients with PD.
Please note that most people who process some of the conditions have never developed Parkinson's disease.
Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink caffeine found in coffee, tea, and cola are less likely to get Parkinson's disease compared to those who don't.
Dr. Prediger RD at the Universidade Federal de Santa Catarina wrote, "Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population older than 60 years".
And, "The available data also suggest that caffeine can improve the motor deficits of PD and that adenosine A2A receptor antagonists such as istradefylline reduces OFF time and dyskinesia associated with standard 'dopamine replacement' treatments".
The results strongly suggested if you drink caffeinated beverages, your risk of PD is decreased substantially.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
With an aim to find a natural ingredient that processes neuroprotective effects against Parkinson's disease, researchers examined the Anthocyanin-rich preparations of Vaccinium species, including bilberry against the oxidative damage in dopaminergic neurons.
V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins showed a significant neuron protection activity by inhibiting oxidation caused by the chain reaction of reactive oxygen species (ROS).
The application was found to be 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.
According to the analysis of the chemical constituents, the neuroprotective effects were attributed to the presence of bioactive compounds anthocyanins and total cyanidins found abundantly in bilberry, but not quercetin or myricetin.
The results suggested that the high potency of anthocyanins processes a potentially neurotoxic reaction against the onset of Parkinson's disease.
Dr. Yao Y, the lead scientist wrote, "(the findings) provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".
Taken altogether, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of Parkinson's disease, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease--phagocyte influx to the brain is promoted by bilberry-enriched diet by Virel A1, Rehnmark A1, Orädd G2, Olmedo-Díaz S1, Faergemann E1, Strömberg I. (PubMed)
(2) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(3) Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms by Prediger RD. (PubMed)
Thursday, 15 June 2023
#Coffee Intake Daily Reduces the Risk of Chronic Liver Diseases, Researchers Show
By Kyle J. Norton
Good news for coffee lovers, intake of coffee daily and regularly showed to express a positive effect in reduced risk and progression of chronic hepatitis. a renowned institute joint study suggested.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
Chronic hepatitis is a condition of liver inflammation caused by hepatitis B and C viruses and certain drugs, lasting at least 6 months.
According to the joint study led by the Michael E. DeBakey VA Medical Center and Baylor College of Medicine, intake of coffee and coffee caffeine modestly may have a profound effect in protection against advanced hepatic fibrosis caused by a viral infection in men with chronic HCV infection.
In the study of 910 patients with chronic HCV infection, 98% male and 38% with advanced hepatic fibrosis with a daily intake of caffeinated coffee higher among controls than patients with advanced fibrosis, researchers filed the following results
1. Coffee was one of the most caffeine injected by participants in the control group.
2. Consumed 100 mg or more of caffeine daily from all sources was found in more participants on a higher percentage of controls (66.0%) group in compared to patients with advanced fibrosis group.
3. Daily intake of 100 mg or more of caffeine also expressed significant hepatoprotective effects in controls.
These findings suggested that caffeine, a major chemical compound may play an important role in reduced risk of chronic hepatitis substantially in compared to noncaffeinated drinkers.
In further support of coffee intake in attenuated risk of the progression of chronic liver diseases (NASH, viral hepatitis, liver cirrhosis, hepatocellular carcinoma)..., Dr. Szántová M and colleagues in the review of experimental, clinical, and large population studies found that coffee consumption showed significant hepatoprotective activities through decreasing mortality, improved antioxidant, antifibrotic, insulin-sensitizing and anticarcinogenic expression. And the key protective components involved in this protection may include Chlorogenic acids, diterpenes (cafestol, kahweol), caffeine, polyphenols, and melanoidin's.
More importantly, Dr. Szántová M,, the lead author said,"(The liver protective activity of coffee against chronic hepatitis may be attributed to action in)modulation of gene expression of key enzymes of fatty acid synthesis, modulation of mRNA included in autophagia, reduction of stress of endoplasmatic reticulum together with the decrease of proinflammatory cytokines and decrease of fibrogenesis are main mechanisms" and " Coffee is a non-pharmacological tool of primary and secondary prevention of chronic liver diseases".
Promisingly, the University of Naples "Federico II, in the study of the relationship between coffee and liver health, indicated that coffee consumption not only showed an inversely associated with the activity of liver enzymes in subjects at risk, including heavy drinkers but also inhibited hepatic steatosis and fibrosis, ...cirrhosis and the risk of hepatocellular carcinoma".
Taking together, there is no doubt that intake of coffee daily and regularly regardless of the number of cups, expressed a significant effect in reduced risk and treatment of chronic liver disease, particularly in chronic hepatitis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C by Khalaf N1, White D1, Kanwal F1, Ramsey D1, Mittal S1, Tavakoli-Tabasi S2, Kuzniarek J3, El-Serag HB4.(PubMed)
(2) [Coffee as hepatoprotective factor].[Article in Czech] by Szántová M, Ďurkovičová Z.(PubMed)
(3) Coffee and liver health by Morisco F1, Lembo V, Mazzone G, Camera S, Caporaso N.(PubMed)
Good news for coffee lovers, intake of coffee daily and regularly showed to express a positive effect in reduced risk and progression of chronic hepatitis. a renowned institute joint study suggested.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
Chronic hepatitis is a condition of liver inflammation caused by hepatitis B and C viruses and certain drugs, lasting at least 6 months.
According to the joint study led by the Michael E. DeBakey VA Medical Center and Baylor College of Medicine, intake of coffee and coffee caffeine modestly may have a profound effect in protection against advanced hepatic fibrosis caused by a viral infection in men with chronic HCV infection.
In the study of 910 patients with chronic HCV infection, 98% male and 38% with advanced hepatic fibrosis with a daily intake of caffeinated coffee higher among controls than patients with advanced fibrosis, researchers filed the following results
1. Coffee was one of the most caffeine injected by participants in the control group.
2. Consumed 100 mg or more of caffeine daily from all sources was found in more participants on a higher percentage of controls (66.0%) group in compared to patients with advanced fibrosis group.
3. Daily intake of 100 mg or more of caffeine also expressed significant hepatoprotective effects in controls.
These findings suggested that caffeine, a major chemical compound may play an important role in reduced risk of chronic hepatitis substantially in compared to noncaffeinated drinkers.
In further support of coffee intake in attenuated risk of the progression of chronic liver diseases (NASH, viral hepatitis, liver cirrhosis, hepatocellular carcinoma)..., Dr. Szántová M and colleagues in the review of experimental, clinical, and large population studies found that coffee consumption showed significant hepatoprotective activities through decreasing mortality, improved antioxidant, antifibrotic, insulin-sensitizing and anticarcinogenic expression. And the key protective components involved in this protection may include Chlorogenic acids, diterpenes (cafestol, kahweol), caffeine, polyphenols, and melanoidin's.
More importantly, Dr. Szántová M,, the lead author said,"(The liver protective activity of coffee against chronic hepatitis may be attributed to action in)modulation of gene expression of key enzymes of fatty acid synthesis, modulation of mRNA included in autophagia, reduction of stress of endoplasmatic reticulum together with the decrease of proinflammatory cytokines and decrease of fibrogenesis are main mechanisms" and " Coffee is a non-pharmacological tool of primary and secondary prevention of chronic liver diseases".
Promisingly, the University of Naples "Federico II, in the study of the relationship between coffee and liver health, indicated that coffee consumption not only showed an inversely associated with the activity of liver enzymes in subjects at risk, including heavy drinkers but also inhibited hepatic steatosis and fibrosis, ...cirrhosis and the risk of hepatocellular carcinoma".
Taking together, there is no doubt that intake of coffee daily and regularly regardless of the number of cups, expressed a significant effect in reduced risk and treatment of chronic liver disease, particularly in chronic hepatitis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C by Khalaf N1, White D1, Kanwal F1, Ramsey D1, Mittal S1, Tavakoli-Tabasi S2, Kuzniarek J3, El-Serag HB4.(PubMed)
(2) [Coffee as hepatoprotective factor].[Article in Czech] by Szántová M, Ďurkovičová Z.(PubMed)
(3) Coffee and liver health by Morisco F1, Lembo V, Mazzone G, Camera S, Caporaso N.(PubMed)
#Healthyfood #Coffee and #CoffeeCaffeine Express a Significantly Profound Effect in Reduced Dermatitis prevalence, According to Studies
By Kyle J. Norton
Good news for coffee lovers, a recent study suggested that coffee consumption daily and regularly has a substantial effect on reduced risk and treatment of dermatitis.
Dermatitis is a condition of irritation of the skin characterized by symptoms of red, swollen, and sore, sometimes with small blisters on the skin.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
The animal study with a skin of C57BL/6j male mice irradiated with UVB (1.0 kJ/m2/day) for 3 days and 5 days after the final session of UVB irradiation with oral administration of coffee at of CA (100 mg/day) or CGA (100 mg/day), 2 major chemical compounds isolated from roasted coffee in the separated group for the 8 days, suggested that group treated with caffeic acid (CA) showed a significant effect on the inhibition of dermatitis in compared to chlorogenic acid (CGA) group.
In fact, the efficacy of coffee caffeine acid in protecting the skin against irritation was attributed to the influence of the chemical compound in a protein related to skin inflammation, namely, the mitogen-activated protein kinase pathway.
Other, in the examined hypothesis of 9763 adults 19 years or older using the 2012-2013 Korean National Health and Nutrition Examination Survey of 4 dietary patterns including fermented foods using principal component analysis on data obtained from a 116-item validated semiquantitative food, after analyzing the returned frequency questionnaires researchers showed that coffee intake displayed a significantly reduced risk of atopic dermatitis.
Together with chocolate, and ice cream, the relative risk odd ratio was 0.53 compared to other groups observed in the study.
Further to support the result of coffee intake in decreased risk of skin irritation, the Chinese study postulated that coffee intake, the beverage intake of the population of 17,497 adults in the 2009-2011 Korean National Health and Nutrition Examination Survey (KNHANES) expressed a significantly profound effect in reduced dermatitis prevalence, after adjusting for potential confounders with the incorporation of sample weights for the complex sample design.
Taking together, one can certainly mention that coffee and coffee caffeine intake, regardless of amount have therapeutic effects in ameliorated risk and treatment of dermatitis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Sources
(1) The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice by Yamate Y1, Hiramoto K, Sato EF. (PubMed)
(2) Fermented food intake is associated with a reduced likelihood of atopic dermatitis in an adult population (Korean National Health and Nutrition Examination Survey 2012-2013) by Park S1, Bae JH2. (PubMed)
(3) Instant noodles, processed food intake, and dietary pattern are associated with atopic dermatitisin an adult population (KNHANES 2009-2011) by Park S1, Choi HS2, Bae JH3. (PubMed)
Good news for coffee lovers, a recent study suggested that coffee consumption daily and regularly has a substantial effect on reduced risk and treatment of dermatitis.
Dermatitis is a condition of irritation of the skin characterized by symptoms of red, swollen, and sore, sometimes with small blisters on the skin.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
The animal study with a skin of C57BL/6j male mice irradiated with UVB (1.0 kJ/m2/day) for 3 days and 5 days after the final session of UVB irradiation with oral administration of coffee at of CA (100 mg/day) or CGA (100 mg/day), 2 major chemical compounds isolated from roasted coffee in the separated group for the 8 days, suggested that group treated with caffeic acid (CA) showed a significant effect on the inhibition of dermatitis in compared to chlorogenic acid (CGA) group.
In fact, the efficacy of coffee caffeine acid in protecting the skin against irritation was attributed to the influence of the chemical compound in a protein related to skin inflammation, namely, the mitogen-activated protein kinase pathway.
Other, in the examined hypothesis of 9763 adults 19 years or older using the 2012-2013 Korean National Health and Nutrition Examination Survey of 4 dietary patterns including fermented foods using principal component analysis on data obtained from a 116-item validated semiquantitative food, after analyzing the returned frequency questionnaires researchers showed that coffee intake displayed a significantly reduced risk of atopic dermatitis.
Together with chocolate, and ice cream, the relative risk odd ratio was 0.53 compared to other groups observed in the study.
Further to support the result of coffee intake in decreased risk of skin irritation, the Chinese study postulated that coffee intake, the beverage intake of the population of 17,497 adults in the 2009-2011 Korean National Health and Nutrition Examination Survey (KNHANES) expressed a significantly profound effect in reduced dermatitis prevalence, after adjusting for potential confounders with the incorporation of sample weights for the complex sample design.
Taking together, one can certainly mention that coffee and coffee caffeine intake, regardless of amount have therapeutic effects in ameliorated risk and treatment of dermatitis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Sources
(1) The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice by Yamate Y1, Hiramoto K, Sato EF. (PubMed)
(2) Fermented food intake is associated with a reduced likelihood of atopic dermatitis in an adult population (Korean National Health and Nutrition Examination Survey 2012-2013) by Park S1, Bae JH2. (PubMed)
(3) Instant noodles, processed food intake, and dietary pattern are associated with atopic dermatitisin an adult population (KNHANES 2009-2011) by Park S1, Choi HS2, Bae JH3. (PubMed)
#Coffee and #CoffeeCaffeine in Reducing the Risk #OralCancer, According to Researchers
By Kyle J. Norton
Coffee and coffee caffeine may have a profound effect on reduced risk and treatment of oral cancer, a renowned cancer society study suggested.
Oral cancer is a medical condition characterized by cell growth disorderly and irregularly in the mouth region, including the lips, tongue, cheeks, floor of the mouth, hard and soft palate, sinuses, and pharynx. At the later stage, infectious cells may travel a distance away from the original site to other tissues and organs.
Coffee, second to green tea is one most popular and social beverages all over the world, particularly in the West, made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
In a prospective US cohort study begun in 1982 by the American Cancer Society, including 968,432 men and women with cancer-free at enrollment, 868 deaths due to oral/pharyngeal cancer occurred during 26 years of follow-up, researchers file the following results, without modifying other factors such as sex, smoking status, or alcohol use.
1. Compared to no/occasional drinkers, patients drinking more than 4 cups of caffeine coffee per day showed a risk of oral/pharyngeal cancer death reduced by 49% with a relative risk of cancer developing of .51.
2. Also, compared to the no and occasional groups, patients drinking more than 4 cups of coffee per day had a relative risk ratio of .61.
According to the Epidemiology Research Program, American Cancer Society, intake of caffeinated coffee showed a significant inverse association in reduced risk and motility of oral/pharyngeal cancer, linearly in dose depending manner.
Additionally, in data extracted from the Miyagi Cohort Study in Japan, including 38,679 subjects aged 40-64 years with no previous history of cancer, 157 cases of oral, pharyngeal, and esophageal cancers identified during 13.6 years of follow-up, returned food frequency questionnaires from participants expressed the results as follow
1. Patients who consumed > or =1 cup of coffee per day had a relative risk ratio of .51 in compared to the drinkers. group.
2. Intake of caffeine, and coffee showed an inverse association with cancer incidence, regardless of sex and cancer site.
More interestingly, the study also emphasized that the risk of cancer is reduced in caffeine coffee consumption, even with people who have been identified with a high risk of cancer developing.
Dr. said, 'Hazard ratios were estimated by the Cox proportional hazards regression model. The risk of oral, pharyngeal, and esophageal cancers was inversely associated with coffee consumption".
More importantly, in support of the above analysis, the study on cases of esophageal cancer(395) is compared to 1066 cases of controls conducted by the Istituto di Ricerche Farmacologiche "Mario Negri" proposed that the same relative risk of 0.6 in both oral/pharyngeal, and esophageal cancer also found in subjects, drinking over >3 cups/ day. And there was no association between caffeine coffee in the expression of reduced risk of cancers.
Taking altogether. coffee and coffee caffeine has the potential used as a functional and therapeutic product in reduced risk and treatment of oral cancer. But Dr. Hildebrand JS, the lead author said, "Research is needed to elucidate biologic mechanisms whereby coffee might help to protect against these often fatal cancers.".
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee, tea, and fatal oral/pharyngeal cancer in a large prospective US cohort by Hildebrand JS1, Patel AV, McCullough ML, Gaudet MM, Chen AY, Hayes RB, Gapstur SM.(PubMed)
(2) Coffee consumption and the risk of oral, pharyngeal, and esophageal cancers in Japan: the Miyagi Cohort Study by Naganuma T1, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji (PubMed)
Coffee and coffee caffeine may have a profound effect on reduced risk and treatment of oral cancer, a renowned cancer society study suggested.
Oral cancer is a medical condition characterized by cell growth disorderly and irregularly in the mouth region, including the lips, tongue, cheeks, floor of the mouth, hard and soft palate, sinuses, and pharynx. At the later stage, infectious cells may travel a distance away from the original site to other tissues and organs.
Coffee, second to green tea is one most popular and social beverages all over the world, particularly in the West, made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
In a prospective US cohort study begun in 1982 by the American Cancer Society, including 968,432 men and women with cancer-free at enrollment, 868 deaths due to oral/pharyngeal cancer occurred during 26 years of follow-up, researchers file the following results, without modifying other factors such as sex, smoking status, or alcohol use.
1. Compared to no/occasional drinkers, patients drinking more than 4 cups of caffeine coffee per day showed a risk of oral/pharyngeal cancer death reduced by 49% with a relative risk of cancer developing of .51.
2. Also, compared to the no and occasional groups, patients drinking more than 4 cups of coffee per day had a relative risk ratio of .61.
According to the Epidemiology Research Program, American Cancer Society, intake of caffeinated coffee showed a significant inverse association in reduced risk and motility of oral/pharyngeal cancer, linearly in dose depending manner.
Additionally, in data extracted from the Miyagi Cohort Study in Japan, including 38,679 subjects aged 40-64 years with no previous history of cancer, 157 cases of oral, pharyngeal, and esophageal cancers identified during 13.6 years of follow-up, returned food frequency questionnaires from participants expressed the results as follow
1. Patients who consumed > or =1 cup of coffee per day had a relative risk ratio of .51 in compared to the drinkers. group.
2. Intake of caffeine, and coffee showed an inverse association with cancer incidence, regardless of sex and cancer site.
More interestingly, the study also emphasized that the risk of cancer is reduced in caffeine coffee consumption, even with people who have been identified with a high risk of cancer developing.
Dr. said, 'Hazard ratios were estimated by the Cox proportional hazards regression model. The risk of oral, pharyngeal, and esophageal cancers was inversely associated with coffee consumption".
More importantly, in support of the above analysis, the study on cases of esophageal cancer(395) is compared to 1066 cases of controls conducted by the Istituto di Ricerche Farmacologiche "Mario Negri" proposed that the same relative risk of 0.6 in both oral/pharyngeal, and esophageal cancer also found in subjects, drinking over >3 cups/ day. And there was no association between caffeine coffee in the expression of reduced risk of cancers.
Taking altogether. coffee and coffee caffeine has the potential used as a functional and therapeutic product in reduced risk and treatment of oral cancer. But Dr. Hildebrand JS, the lead author said, "Research is needed to elucidate biologic mechanisms whereby coffee might help to protect against these often fatal cancers.".
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee, tea, and fatal oral/pharyngeal cancer in a large prospective US cohort by Hildebrand JS1, Patel AV, McCullough ML, Gaudet MM, Chen AY, Hayes RB, Gapstur SM.(PubMed)
(2) Coffee consumption and the risk of oral, pharyngeal, and esophageal cancers in Japan: the Miyagi Cohort Study by Naganuma T1, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji (PubMed)
#TualangHoney Induces #Cancer Cells Apoptosis by Exhibiting #Cell Degradation and Reduced in Numbers, According to Studies
By Kyle J. Norton
Mouth/oral cancer is a medical condition associated with irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.
Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.
According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.
The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection, and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.
Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at an increased risk of the disease.
The Canadian Cancer Society in the explanation of how a weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".
Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"
If you experience symptoms of a sore that does heal within a few days, a growth, lump, or thickening of the skin or lining of your mouth, tongue, and jaw pain that does not heal in weeks, persistent sore throat, difficulty or chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener.
On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effects compared to surgery followed by chemo and. or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.
The study procedures include several concentrations of Tualang honey (1% - 20%) applied directly on OSCC cell lines for 3, 6, 12, 24, 48, and 72 hours.
The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit to detect cell apoptosis.
Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.
In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane, and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.
The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.
The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.
The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.
Dr. Ghashm AA the lead scientist in the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".
Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.
Due to the limitation of the above study, further data collection large example size, and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
Mouth/oral cancer is a medical condition associated with irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.
Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.
According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.
The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection, and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.
Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at an increased risk of the disease.
The Canadian Cancer Society in the explanation of how a weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".
Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"
If you experience symptoms of a sore that does heal within a few days, a growth, lump, or thickening of the skin or lining of your mouth, tongue, and jaw pain that does not heal in weeks, persistent sore throat, difficulty or chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener.
On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effects compared to surgery followed by chemo and. or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.
The study procedures include several concentrations of Tualang honey (1% - 20%) applied directly on OSCC cell lines for 3, 6, 12, 24, 48, and 72 hours.
The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit to detect cell apoptosis.
Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.
In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane, and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.
The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.
The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.
The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.
Dr. Ghashm AA the lead scientist in the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".
Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.
Due to the limitation of the above study, further data collection large example size, and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
#Bromelain, #Trypsin, and #Rutin (ERC) Combination, An Effective and Safe Alternative to NSAIDs Against Osteoarthritis, Researchers Say
By Kyle J. Norton
Osteoarthritis (OA), a form of arthritis, is a chronic condition found mostly in the elderly and caused by wear and tear on a joint.
The University of Porto Medical School in the definition of OA advised that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).
The condition affects over 25 million people in the United States.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty in moving the joint or joints. The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function and quality of life through pharmacological, nonpharmacological, and surgical treatments.
The most common causes of OA are
* Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints often associated with senescence invertebrates. arising from long-term wear and tear, heavy long-term use, or specific injuries. The improper repair process of injuring joints can also result in symptoms of osteoarthritis (OA) in old age, according to TCM.
* Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA), such as vitamin D. On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA).
* Cartilage
Cartilage is a flexible connective tissue that cushioned the ends of bones in the joints that allows the joints to move smoothly. Rough or worn down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone.
The above causes of Osteoarthritis (OA) may also be the result of injury, overuse, and Rheumatoid Arthritis,
In other words, lifelong protection of cartilage and joint damage and injury have an inverse association with the risk of OA.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural resource for the treatment of osteoarthritis, researchers compared the effect of a combination of bromelain, trypsin, and rutin (ERC) to diclofenac.
The study included 103 patients with osteoarthritis of the knee randomly receiving either the combination of bromelain, trypsin, and rutin or diclofenac including 52 patients treated with ERC and 51 patients treated with the diclofenac.
According to the tested assay,
* The mean value of Lequesne's Algofunctional Index (LFI) decreased from 13.0 to 9.4 in the ERC group and from 12.5 to 9.4 in the diclofenac group.
* Non-inferiority of ERC was demonstrated by both primary criteria, LFI (MW = 0.5305; CI-LB = 0.4171) and complaint index (MW = 0.5434; CI-LB = 0.4296).
Where LFI is a measurement of the severity of osteoarthritis.
* ERC also showed a superior improvement in secondary efficacy criteria, compared to diclofenac
* The global judgment of efficacy by physicians resulted in at least good ratings for 51.4% of the ERC patients, and for 37.2% of the diclofenac patients.
Furthermore, the majority of patients rate the tolerability in both drug groups as very good or good.
Based on the finding, researchers wrote, " ERC can be considered as an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful episodes of OA of the knee".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's Karate Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
Osteoarthritis (OA), a form of arthritis, is a chronic condition found mostly in the elderly and caused by wear and tear on a joint.
The University of Porto Medical School in the definition of OA advised that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).
The condition affects over 25 million people in the United States.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty in moving the joint or joints. The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function and quality of life through pharmacological, nonpharmacological, and surgical treatments.
The most common causes of OA are
* Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints often associated with senescence invertebrates. arising from long-term wear and tear, heavy long-term use, or specific injuries. The improper repair process of injuring joints can also result in symptoms of osteoarthritis (OA) in old age, according to TCM.
* Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA), such as vitamin D. On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA).
* Cartilage
Cartilage is a flexible connective tissue that cushioned the ends of bones in the joints that allows the joints to move smoothly. Rough or worn down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone.
The above causes of Osteoarthritis (OA) may also be the result of injury, overuse, and Rheumatoid Arthritis,
In other words, lifelong protection of cartilage and joint damage and injury have an inverse association with the risk of OA.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural resource for the treatment of osteoarthritis, researchers compared the effect of a combination of bromelain, trypsin, and rutin (ERC) to diclofenac.
The study included 103 patients with osteoarthritis of the knee randomly receiving either the combination of bromelain, trypsin, and rutin or diclofenac including 52 patients treated with ERC and 51 patients treated with the diclofenac.
According to the tested assay,
* The mean value of Lequesne's Algofunctional Index (LFI) decreased from 13.0 to 9.4 in the ERC group and from 12.5 to 9.4 in the diclofenac group.
* Non-inferiority of ERC was demonstrated by both primary criteria, LFI (MW = 0.5305; CI-LB = 0.4171) and complaint index (MW = 0.5434; CI-LB = 0.4296).
Where LFI is a measurement of the severity of osteoarthritis.
* ERC also showed a superior improvement in secondary efficacy criteria, compared to diclofenac
* The global judgment of efficacy by physicians resulted in at least good ratings for 51.4% of the ERC patients, and for 37.2% of the diclofenac patients.
Furthermore, the majority of patients rate the tolerability in both drug groups as very good or good.
Based on the finding, researchers wrote, " ERC can be considered as an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful episodes of OA of the knee".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's Karate Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
#Healthy #GreenTea's #Polyphenols Exhibit Cytotoxic Effects Against #OralCancer Cells in Vitros, Researchers Find
By Kyle J. Norton
Green tea may have a profound and sustainable effect in reduced risk and treatment of oral cancer, some scientists suggested.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will neutralize the risk.
Oral cancer is a medical condition characterized by irregular cell growth in the tissues of the mouth area. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistic, 1 in 75 men and 1 in 150 women will be diagnosed with oral cancer during their lifetime
In the review of medical literature online, green tea extract green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) showed to reduced risk and treatment of oral cancers through some particular mechanisms.
In human oral squamous carcinoma cells (SCC-25, SCC-9), application of green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) suppressed SIRT3 mRNA and protein expression in the induction of SCC-25 cells proliferation, through antioxidant effect in the attenuated function of SIRT3 in contribution to cancer cell survival via mRNA transmitting by modulating oxidative stress.
Some researchers also insisted that SIRT 3 may be considered a bio-maker for targeting the stage and grade of cancer progression.
Further analysis, suggested that green tea bioactive EGCG also up-regulated the nuclear localization of the estrogen-related receptor α (ERRα) in inhibited oral cell carcinoma tumors by regulating SIRT3 in the expression of cancer cellular metabolism.
Interestingly, EGCG application also displayed a significant effect in modulating the mRNA expressions of SIRT3-associated cancer cells in the induction of cell proliferation by inhibiting the production of reactive oxidative species in precipitated chain reactive in the initiation of cancer cell division.
More importantly, from a ROS perspective, oral administration of green tea EGCG by targeting the protein SIRT3 exhibited an antioxidant effect in protecting healthy cells without affecting the formation of ROS to facilitate oral cancer cell apoptosis through cytotoxicity.
Dr. Tao L, after taking into account other cofounders, said, "SIRT3 represents a novel potential target through which EGCG exerts differential prooxidant effects in cancer and normal cells".
Further observation of the efficacy of green tea extract EGCG, also indicated that EGCG treatment increased the production of mitochondrial H2O2 in SCC-25 cells within 6 hours before inducing cancer cell apoptosis.
In antioxidant activity. green extract EGCG induced differential expression of genes related to antioxidant defense in oral cancer cells and gingival fibroblasts, which are critical in sustaining inflammation in periodontal disease through an ameliorated expression of metallothionein 3 in the induction of degeneration of cells and superoxide dismutase 2/3, and thioredoxin reductase 2 in facilitate oxidative stress to induce oncogenesis without increased cell proliferation of human gingival fibroblast -1 (HGF-1).
Additional examination indicated that the application also exhibited anti-oral cancer apoptosis by increased expression of mitochondrial ROS and mitochondrial dysfunction in facilitated intoxicate effect without causing harm to the gingival fibroblasts through antioxidant selective activities.
Green tea with promising chemo properties due to their decreased dose and limited toxicity profiles, Dr. Ramshankar V1, the lead author said, "It is worthwhile to include green tea extract in an oral screening program for evaluating the pre-malignant lesions comparing the results between the treated and untreated group. Given the wide acceptance of green tea, its benefits may help in effective chemo-prevention oral cancer".
Taken together, green tea with abundant bioactive polyphenols may be considered as a function for prevention and used as an adjunct therapy in combination with the standard treatment of oral cancer. Intake of green tea extract as a supplement is not recommended as toxicity has been reported in a number of cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD. (PubMed)
(2) The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells.by Tao L1, Forester SC, Lambert JD. (PubMed)
(3) Chemoprevention of oral cancer: Green tea experience by Ramshankar V1, Krishnamurthy A2. (PubMed)
Green tea may have a profound and sustainable effect in reduced risk and treatment of oral cancer, some scientists suggested.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will neutralize the risk.
Oral cancer is a medical condition characterized by irregular cell growth in the tissues of the mouth area. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistic, 1 in 75 men and 1 in 150 women will be diagnosed with oral cancer during their lifetime
In the review of medical literature online, green tea extract green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) showed to reduced risk and treatment of oral cancers through some particular mechanisms.
In human oral squamous carcinoma cells (SCC-25, SCC-9), application of green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) suppressed SIRT3 mRNA and protein expression in the induction of SCC-25 cells proliferation, through antioxidant effect in the attenuated function of SIRT3 in contribution to cancer cell survival via mRNA transmitting by modulating oxidative stress.
Some researchers also insisted that SIRT 3 may be considered a bio-maker for targeting the stage and grade of cancer progression.
Further analysis, suggested that green tea bioactive EGCG also up-regulated the nuclear localization of the estrogen-related receptor α (ERRα) in inhibited oral cell carcinoma tumors by regulating SIRT3 in the expression of cancer cellular metabolism.
Interestingly, EGCG application also displayed a significant effect in modulating the mRNA expressions of SIRT3-associated cancer cells in the induction of cell proliferation by inhibiting the production of reactive oxidative species in precipitated chain reactive in the initiation of cancer cell division.
More importantly, from a ROS perspective, oral administration of green tea EGCG by targeting the protein SIRT3 exhibited an antioxidant effect in protecting healthy cells without affecting the formation of ROS to facilitate oral cancer cell apoptosis through cytotoxicity.
Dr. Tao L, after taking into account other cofounders, said, "SIRT3 represents a novel potential target through which EGCG exerts differential prooxidant effects in cancer and normal cells".
Further observation of the efficacy of green tea extract EGCG, also indicated that EGCG treatment increased the production of mitochondrial H2O2 in SCC-25 cells within 6 hours before inducing cancer cell apoptosis.
In antioxidant activity. green extract EGCG induced differential expression of genes related to antioxidant defense in oral cancer cells and gingival fibroblasts, which are critical in sustaining inflammation in periodontal disease through an ameliorated expression of metallothionein 3 in the induction of degeneration of cells and superoxide dismutase 2/3, and thioredoxin reductase 2 in facilitate oxidative stress to induce oncogenesis without increased cell proliferation of human gingival fibroblast -1 (HGF-1).
Additional examination indicated that the application also exhibited anti-oral cancer apoptosis by increased expression of mitochondrial ROS and mitochondrial dysfunction in facilitated intoxicate effect without causing harm to the gingival fibroblasts through antioxidant selective activities.
Green tea with promising chemo properties due to their decreased dose and limited toxicity profiles, Dr. Ramshankar V1, the lead author said, "It is worthwhile to include green tea extract in an oral screening program for evaluating the pre-malignant lesions comparing the results between the treated and untreated group. Given the wide acceptance of green tea, its benefits may help in effective chemo-prevention oral cancer".
Taken together, green tea with abundant bioactive polyphenols may be considered as a function for prevention and used as an adjunct therapy in combination with the standard treatment of oral cancer. Intake of green tea extract as a supplement is not recommended as toxicity has been reported in a number of cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD. (PubMed)
(2) The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells.by Tao L1, Forester SC, Lambert JD. (PubMed)
(3) Chemoprevention of oral cancer: Green tea experience by Ramshankar V1, Krishnamurthy A2. (PubMed)
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