#Greentea's #Polyphenols Inhibit Human Immunodeficiency Virus -1 (#HIV-1) Infection Through Their Cytotoxicity, Researchers Say

By Kyle J. Norton

Green and black tea may have a therapeutic and positive effect in reducing the risk of HIV 1 infection, some scientists suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated by acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...

According to statistics, approximately 36.7 million people worldwide lived with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.


According to the investigation of Theaflavins, the major components of tea polyphenols extracted from brewed black tea and green tea inhibited HIV-1 entry by targeting gp41 which is a transmembrane protein with function embedded with an outer coat of HIV to enter and infected host cells.

However, due to the unstable and purification of the individual theaflavins, natural preparation containing 90% of theaflavins (TFmix) in most study was used to experiment with its effect against HIV-1 microbicide for preventing HIV sexual transmission.

In vitro using p24 production and luciferase assays, TFmix exhibited potent anti-HIV-1 activity on lab-adapted and primary HIV-1 strains with IC(50), the concentration of an application that gives half-maximal response in dose of less than 1.20 μM, through targeting the gp41 in inhibited virus-host membrane fusion during infection mediated by the formation of six-helix bundle (6HB).

In other words, theaflavins administration was found to initiate potent anti-HIV-1 activity by targeting the viral entry step through the disruption of the gp41 6-HB core structure,

Furthermore, application of theaflavins (TFmix) also inhibited reverse transcriptase (RT) activity, an RNA-dependent DNA, which is the process of replication of RNA from a DNA template through polymerase (DNAP) enzyme in forming new copies of DNA, in the form of nucleic acid molecules, with the IC(50) about 8-fold higher of theaflavins (TFmix) concentration than that for inhibiting gp41 6-HB formation.

In peptide fragments, derived from prostatic acidic phosphatase secreted in large amounts into human semen to form amyloid fibrils plaques with the function to induce viral infection (SEVI), through capturing the HIV virions and direct them to target cells into liver cells to initiate entry step, during sexual activity, injection of green tea epigallocatechin-3-gallate (EGCG) inhibited the expression of SEVI and revoked semen in mediated enhancement of HIV-1 infection through precipitated viral degradation without induced healthy cell toxicity.

Further analysis of green tea EGCG activity using HIV-1 infectivity on human CD4+ T cells, at a physiologic concentration of 6μM, EGCG significantly inhibited HIV-1 p24 antigen production in the expression of acute infection in both HIV-1 clinical isolates and laboratory-adapted subtypes B C, D, and G.

Particularly, EGCG-induced inhibition of HV-1 infectivity was not due to cytotoxicity, cell growth inhibition, nor apoptosis but blocking the HIV activity in the attachment of HIV-1-gp120, a glycoprotein exposed on the surface of the HIV envelope to the CD4 molecule in the entry point in initiated infectivity. Dr. Christina L., the lead author concluded, "(by) preventing the attachment of HIV-1-gp120 to the CD4 molecule, EGCG inhibits HIV-1 infectivity. As this inhibition can be achieved at physiologic concentrations, the natural anti-HIV agent, EGCG, is a candidate as an alternative therapy in HIV-1 therapy".

The information findings suggested that green tea with abundant bioactive polyphenols Theaflavins including epigallocatechin-3-gallate (EGCG) may be considered as a functional food to the ameliorated risk of HIV 1 infection by blocking the complex process in initiation.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection by Hauber I1, Hohenberg H, Holstermann B, Hunstein W, Hauber J.(PubMed)
(2) A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection by Yang J1, Li L, Tan S, Jin H, Qiu J, Mao Q, Li R, Xia C, Jiang ZH, Jiang S, Liu S.(PubMed)
(3) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41 by Liu S1, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S.(PubMed)
(4) Preclinical Development of the Green Tea Catechin, Epigallocatechin Gallate, as an HIV-1 Therapy by Christina L. Nance, Ph.D.,a Edward B. Siwak, Ph.D.,b and William T. Shearer, MD, Ph.Da(PMC)
(5) The HIV-1 gp41 N-terminal heptad repeat plays an essential role in membrane fusion by Sackett K1, Shai Y.(PubMed)

#Healthyfood Tomatoes Inhibit Hepatic Steatosis Through their Antioxidant Activities in Vivos, Researchers Find

By Kyle J. Norton

Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.

In other words, if the intrahepatic fat of your liver is more than 5% of your liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced nonalcoholic fatty liver disease.

Epidemiologically, hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication, and/or hepatic disorders.

There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.

People who are obese, have the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, and use hepatotoxic medications total parenteral nutrition (TPN) are at an increased risk of hepatic steatosis.


Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.

Dr. Michael D. Roberts, the lead scientist wrote, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis)".

And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes. These findings outline the early stages of NAFLD development before overt liver inflammation and advanced liver disease".

The results strongly suggested the risk of the Western diet on hepatic steatosis developing.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of hepatic steatosis, researchers examined the effect of tomato consumption on biomarkers and gene expression related to lipid metabolism in rats with induced steatosis.

The study included 24 adult male Sprague-Dawley rats (8 weeks old) randomly assigned to (n = 6 rats/group) four experimental groups, including NA (normal diet and water), NL (regular diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).

According to the tested assays, before the treatment of tomato, the HA group fed high-fat diet-induced hepatic steatosis confirmed by the levels of alanine aminotransferase and aspartate aminotransferase, an indication of liver stress and injury.

Tomato treated group showed a significant increase in levels of lycopene and its secondary metabolites in the livers of these animals, particularly in HL than in the NL group, apparently due to higher absorption (63.07 vs. 44.45%).

Furthermore, tomato treated group protected the liver by alleviating oxidative stress through the reduction of isoprostanes in the urine observed by increased levels of antioxidant enzymes.

Moreover, levels of high-density lipoprotein were also increased in the HL group compared to the HA group.

Interestingly, overexpression of several genes related to lipid metabolism was also found in the HL group compared to nontreatment groups.

In other words, tomatoes inhibited the onset and progression of hepatic steatosis. in high-fat diet mice by inhibiting liver oxidative stress and enhancing lipid metabolism.

Dr. Martín-Pozuelo G, the lead scientist wrote, "The consumption of tomato juice and tomato products reduced hallmarks of steatosis, plasmatic triglycerides, and very low-density lipoproteins, and increased lipid metabolism by inducing an overexpression of genes involved in more efficient fatty acid oxidation".

Taken altogether, tomatoes may be considered a dietary supplement for the prevention and treatment of hepatic steatosis, pending a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis by Martín-Pozuelo G1, Navarro-González I, González-Barrio R, Santaella M, García-Alonso J, Hidalgo N, Gómez-Gallego C, Ros G, Periago MJ. (PubMed)
(2) Lipid biomarkers and metabolic effects of lycopene from tomato juice on the liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu, Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins, Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)

#Coffee Intake Daily Is Associated with Decreased Risk of #EsophagealCancer, According to Studies

By Kyle J. Norton

Coffee intake regularly may decrease the risk of esophageal cancer developing, according to the study conducted by the Istituto di Ricerche Farmacologiche "Mario Negr".

Esophageal cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the esophagus, the food tube that runs between the throat and stomach.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.

According to the database extracted from hospital-based case-control studies conducted in Italy and Switzerland on oral/pharyngeal cancer included 749 cases and 1772 controls, with esophageal cancer 395 cases and 1066 controls, researchers indicated that the relative ratio of esophageal cancer for patients drinking >3 cups/day was 0.6. And the inverse association was more profound if taking other factors into account.

The study also insisted, there is no association between the risk of esophageal cancer and decaffeinated coffee drinking and people consuming coffee in low amounts.


Additionally, in the study of 38,679 subjects aged 40-64 years with no previous history of cancer, 157 cases of oral, pharyngeal, and esophageal cancers identified during 13.6 years of follow-up, coffee intake regularly of 1 cup or more showed an inverse association in the risk of esophageal cancer, regardless to sex and cancer site.

The relative hazard ratio of these groups was 0.51 compared to no consumption group.

Further to confirm the positive effect of coffee intake in attenuated esophageal cancer risk, the Catalan Institute of Oncology (ICO-IDIBELL) conducted a study in examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition, suggested that according to the returned questionnaire
1. During a mean follow-up of 11.1 years, coffee intake regular patients showed a significantly lower risk of esophageal cancer, compared to the nondrinkers group.
2. Men's coffee consumption was inversely related to esophageal squamous cell carcinoma (ESCC), but not among women.
3. Risk of esophageal cancer was reduced in current smokers with coffee consumption.


Taking all together, coffee consumption daily and regularly is associated with a reduced risk of esophageal cancer, particularly in men and smokers.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Coffee and tea intake and risk of oral, pharyngeal and esophageal cancer by Tavani A1, Bertuzzi M, Talamini R, Gallus S, Parpinel M, Franceschi S, Levi F, La Vecchia C.(PubMed)
(2) Coffee consumption and the risk of oral, pharyngeal, and esophageal cancers in Japan: the Miyagi Cohort Study by Naganuma T1, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji I.(PubMed)
(3) Tea and coffee consumption and risk of esophageal cancer: the European prospective investigation into cancer and nutrition study by Zamora-Ros R1, Luján-Barroso L, Bueno-de-Mesquita HB, Dik VK, Boeing H, Steffen A, Tjønneland A, Olsen A, Bech BH, Overvad K, Boutron-Ruault MC, Racine A, Fagherazzi G, Kuhn T, Katzke V, Trichopoulou A, Lagiou P, Trichopoulos D, Tumino R, Panico S, Vineis P, Grioni S, Palli D, Weiderpass E, Skeie G, Huerta JM, Sánchez MJ, Argüelles M, Amiano P, Ardanaz E, Nilsson L, Wallner B, Lindkvist B, Wallström P, Peeters PH, Key TJ, Khaw KT, Wareham NJ, Freisling H, Stepien M, Ferrari P, Gunter MJ, Murphy N, Riboli E, González CA.(PubMed)

#Herbal #Bilberries Protect the Kidney Against Damage by improving Their #Antioxidant Activities, According to Studies

By Kyle J. Norton

Kidneys are one of the main detoxed organs which filter the blood before passing the clear blood back to the circulatory system, located on either side of the spine.

In other words, kidneys remove wastes and extra water from the blood to form urine.

Most wastes in the blood are the results of from normal breakdown of active muscle and the foods you eat.

Believe it or not,1 in 3 adults in the United States are at risk of getting kidney disease. According to the statistics provided by the CDC, approximately, 30 million people, or 15% of US adults have chronic kidney disease (CKD), including 48% of those with severely reduced kidney function but not on dialysis are not aware of having CKD.

Nephrotoxicity caused by overdose or long-term use of medication and exposure to toxins is one of the most common kidney problems, leading to acute and chronic kidney damage.

Other risk factors associated with kidney damage include diabetes, high blood pressure, and cardiovascular disease.


Some researchers suggested the rise of kidney disease in US adults may be influenced by the increase of obesity, the condition of excess fat accumulation, particularly on the waist.


Dr. Csaba P. Kovesdy, the lead scientist wrote, "Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade".


And "In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long term. The incidence of obesity-related glomerulopathy has increased 10-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis and for a number of malignancies including kidney cancer".

Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

With an aim to find a potent compound that protects the kidney against damage, researchers examined the anti-nephrotoxic activity of bilberry ( Vaccinium myrtillus L.).

In an experimental model, induced serious kidney damage by a single intraperitoneal administration of 200 mg/kg KBrO3 induction of the increase in serum blood urea nitrogen (BUN) and creatinine levels, researchers compared the effects of five-day oral administration of bilberry ( Vaccinium myrtillus L.) extract at 50, 100, and 200 mg/kg.

All doses normalized the levels of creatinine and reversed serum BUN.

In other words, bilberry extracts protect the kidney by inhibiting the toxicity caused by the injection of 200 mg/kg KBrO3.


The efficacy of bilberry extracts was attributed also to decreased kidney stress marker malondialdehyde (MDA), expression of free radicals associated with nitric oxide (NO), and xanthine oxidase (XOD) levels.

Furthermore, bilberry extracts improved oxygen radical absorbance capacity (ORAC) levels in kidney tissue against the overexpression of ROS and NOS.

The results strongly suggested that bilberry protects the kidney by reducing the degree of oxidative stress and kidney damage induced by KBrO3.

Dr. Bao L, the lead scientist wrote in the final report, "These findings demonstrate that the protective effect of bilberry extract is attributed to its free radical scavenging activity and lipid peroxidation inhibitory effect".

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of diseases involved in kidney damage, pending the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effects of bilberry (Vaccinium myrtillus L.) extract on KBrO3-induced kidney damage in mice by Bao L1, Yao XS, Tsi D, Yau CC, Chia CS, Nagai H, Kurihara H. (PubMed)
(2) Obesity and Kidney Disease. Hidden Consequences of the Epidemic by Csaba P. Kovesdy,1,2 Susan L. Furth,3 Carmine Zoccali,4 and on behalf of the World Kidney Day Steering Committee. (PMC)

#Healthyfood #Garlic and #Onion Process Anti-#Parasitic, #Bacterial and #Fungal Activities, Researchers Say

By Kyle J. Norton

Microbial infection is a disease caused by microorganisms, including viruses, bacteria, fungi, or parasites.
Most healthy adults can be recovered quickly without using antibiotics.

However, if the immune system or antibiotics used cannot wipe off all the micro invaders in a specific time, approximately 3 to 8 weeks, it will lead to the compromise, leading to chronic infection, such as asthma, airway inflammation, pneumonia, and other respiratory diseases.

Viruses are made up of a piece of genetic material, such as DNA or RNA enclosed in a coat of protein. Virtual infection is a result of a viral invasion that uses components of invaded cells to multiply, leading to the damage or alternation of the DNA or RNA of the host cells.

Bacterias are single-cell organisms that cause infectious diseases by multiplying after finding a specific tissue or organ. Pathogenic bacteria also challenge the immune system for survival.

Fungi are a class of living organisms, including yeasts, molds, and mushrooms. fungal infections in most cases start in the lungs or on the skin. The disease has been found mostly in people with a weakened immune system and long-term use of antibiotics.

Parasites are living organisms that live and extract food from a host. Parasites are also completely dependent on the host for survival, including lice, ringworms, pinworms, and scabies.


Believe it or not, over 70 percent of parasites are not visible to the human eye, such as the malarial parasite, However, some parasites such as worms can reach many meters in length.

According to the statistics provided by the CDC, infectious diseases cause over 15 million visits to physician offices and 3.7 million visits to the emergency department in the US every year.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

In Anti-Parasitic activity

On finding a potential compound for the treatment of infectious diseases, researchers examined the anti-parasitic activity of garlic and onion.

According to the tested analysis, the abundance of a number of sulfur secondary metabolites in garlic and one (zwiebelane) in the onion extract killed both types of parasites (On Trypanosoma brucei and Leishmania tarentolae) efficiently.

Furthermore, both extracts also inhibited the Trypanosoma brucei trypanothione reductase irreversibly.

The combinations of garlic and onion with common trypanocidal and leishmanicidal drugs exerted a synergistic effect in 50% of all tested cases.

Moreover, by additional differentiation of the chemical compound in both extracts, researchers found that the efficacy of garlic and onion against the tested parasites may be related to the amount and the profile of sulfur-containing compounds by inhibiting certain materials in the parasitic cells.

In Bacterial and Fungal Activity
Additionally, in the comparison of the antimicrobial activities of onion (Allium cepa), garlic (Allium sativum), mint (Mentha spicata), thyme (Thymus vulgaris), oak (Quercus), aloe vera (Aloe barbadensis Miller), and ginger (Zingiber officinale).

All extracts of these medicinal herbs in 80% methanol, 80% ethanol, 80% acetone, and 100% water demonstrated a significant effect against selected microbial strains, including Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pasteurella multocida, and fungal strains, Aspergillus niger, Aspergillus flavus, Rhizopus solani, and Alternaria alternata.

However, The extracts show better antimicrobial activity against bacterial strains as compared to fungal strains.

Taken altogether, onion may be considered a remedy for the prevention and treatment of diseases caused by parasitic and microbial infections pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
-
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of Phenolic Compounds and Antioxidant and Antimicrobial Activities of Some Common Herbs by Abdul Qadir M1, Shahzadi SK1, Bashir A2, Munir A2, Shahzad S. (PubMed)
(2) Tulbaghia violacea and Allium ursinum Extracts Exhibit Anti-Parasitic and Antimicrobial Activities by Krstin S1, Sobeh M2, Braun MS3, Wink M. (PubMed)

#Honey Inhibits the Growth of #BladderCancer in Vivos and Vitros, Scientists Find

By Kyle J. Norton

Scientists may have found a natural food source that processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.
Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.

Most cases of primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.

At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distant metastasis to infect other healthy tissue and organ through the circulation of blood and fluids.

At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.

Researchers do not the exact causes of bladder cancer. But certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition, and exposure to chemicals are at a higher risk of the onset of the disease.

The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.

In fact, most people with some of the above risk factors have never developed bladder cancer even if they are associated with the increased risk all their life.

Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.

Sadly, People with gene mutation are at a 70 % higher risk of bladder cancer compared to those who do not.

Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for the tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of the p53 gene".

And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener.

With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.


The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).

In vitro studies, the application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.

Broodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.

FCM showed a lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.

Flow cytometry (FCM). in the measurement of cancer cells physical and chemical characteristics showed lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.

Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.

These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.

And, Honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.

Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".

Taken altogether, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.


However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)

#Healthyfood #NavyBeans Promote the #ColonHealth through Modulating Colonic Microbiome Metabolism, Scientists Suggest

By Kyle J. Norton

The colon formed part of the digestive system plays a critical role to absorb water from the small bowel contents and break down of certain materials in the feces into substances which are reabsorbed and reused by the body.

Colon health is the process to enhance the function of the colon through many mechanisms, particularly in improving the ratio of gut microbiota.

Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, suppose the bad bacteria are overgrowing compared to good bacteria. In that case, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.

The most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.

In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat, and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.

Epidemiological studies suggested overweight and obese people show dysbiosis characterized by a lower diversity. Imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.

Some researchers suggested that we can optimize our colon health by manipulating the gut microbiota through diet by increasing the intake of fiber, prebiotic, and probiotic foods.


Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".

And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

In finding a natural compound for improving colon health, researchers evaluated the effect of navy beans in the modulation of host-microbiome metabolism.

The 4-week, randomized controlled trial with overweight and obese CRC survivors involved the consumption of 1 meal and 1 snack daily, containing 35 g of cooked navy bean or macronutrient-matched meals and snacks with 0 g of navy beans for the control group (n = 18).

According to the assessment of the impact on the human stool metabolome, which includes the presence of navy bean metabolites, * 26 significantly different metabolites were found at day 28 in the navy bean group compared to the participants' baseline (p ≤ 0.05) and to the control group.

* Additionally, of the 560 total metabolites identified from the cooked navy beans, there was 237 possible navy bean-derived metabolites identified in the stool of participants consuming navy beans.

* Most importantly, the stool relative abundance of ophthalmic increased 5.25-fold for navy bean consumers strongly suggesting that navy beans in the glutathione regulation and cancer control were attributed to detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis.

More precisely, navy bean protects the colon cell's integrity by exciting detoxed, antioxidant, anti-proliferation, and anti-apoptotic activity.

Based on the findings, researchers said, "These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merits further investigation for improving colonic health after long-term consumption".

Taken altogether, the navy bean may be considered a remedy for the improvement of colon health, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen. (PMC)