Friday, 9 June 2023

#Greentea Processes Anti Antihistamine Activities AgIainst the Risk of Acute and Chronic #Skindiseases, Researchers Suggest

By Kyle J. Norton

Green tea may have a therapeutic and positive effect on reducing the risk of the sudden appearance of hives, some scientists suggested.
Hives, also known as Urticaria, is a condition characterized by a sudden outbreak of swollen, pale red bumps or plaques on the skin.

The exact causes of hives are unknown, However, epidemiological studies all agreed that a set of conditions such as allergic reactions, chemicals in foods, insect stings, sunlight exposure, or medications can all cause histamine release initiated the onset of hives.

Certain diseases such as thyroid disease, hepatitis, infection,.... and cancer are also associated with the onset of chronic hives.

Acute conditions of Hives are diseases that last less than six weeks.

The most common symptoms of chronic hives include red, itchy, or skin color welts on the skin that appear in varying shapes and sizes and anywhere in the body that last no longer than six to 12 hours.


In severe cases, chronic hives may induce symptoms of dizziness. wheezing. difficulty breathing,........ and swelling of the tongue, lips, or face.

According to statistics, approximately, 20 percent of people may develop hives at some time in their life.

According to the return of 437 response rate (95%) questionnaires from the fourth to sixth-grade students at an elementary school in Yongin conducted by the J Dankook University to examine the food allergy that affects between 10.9% to 12.6% general population(2).* The prevalence of food allergy among respondents was 19.7%.
* The the most common food allergy-related symptoms were urticaria


These results suggested that food allergens are one of the leading causes of the onset of hives among children between ages 9 - 12.

The study also suggested that green tea inhibits hives onset through its antihistamine effect.

Furthermore, Green tea also processes anti-inflammatory properties that can soothe swelling and reduce skin discomfort.

According to the Universidad de Málaga and CIBER de Enfermedades Raras (CIBERER), green tea bioactive compound epigallocatechin-3-gallate (EGCG), exerted anti-allergen caused by histamine-producing cells through alterations in their behavior such as their proliferative, adhesion, migration, and invasion potentials.

By exhibiting the anti antihistamine effect, green tea may have potency in reduced risk of acute and chronic skin diseases caused by food allergens, including hives(2).

Dr. Melgarejo E, the lead author said, "Green tea EGCG has been shown to have potent anti-inflammatory, anti-tumoral, and anti-angiogenic effects and to be a potent inhibitor of the histamine-producing enzyme, histidine decarboxylase"(2).

Taken together, green tea and its bioactive phytochemical EGCG may be considered as a functional food in inhibit hives caused by overexpression of histamine.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Kyle J. Norton(Scholar, Master of Nutrition, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Diet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis by Murzaku EC1, Bronsnick T2, Rao BK1(PubMed)
(2) Targeting of histamine producing cells by EGCG: a green dart against inflammation? by Melgarejo E1, Medina MA, Sánchez-Jiménez F, Urdiales JL(PubMed)
(3) Food allergy knowledge, perception of food allergy labeling, and level of dietary practice: A comparison between children with and without food allergy experience by Choi Y1, Ju S2, Chang H2.(PubMed)

The Coffee Intake Effects on #GastricUlcer (GU), #DuodenalUlcer (DU),... Caused by Helicobacter Pylori (HP) Infection, According to Studies

By Kyle J. Norton

Epidemiological studies, linking coffee consumption daily and regularly associated to risk of gastritis developing caused by overproduction of bacteria Helicobacter pylori (H. pylori) in induced infection, have been inclusive.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Gastritis is a condition of inflammation, irritation, or erosion of stomach lining caused by bacteria Helicobacter pylori (H. pylori) overexpression located at the lining of the stomach.

In a study of a total of 447 patients aged 15-79 had not had peptic ulcer disease or treatment for H pylori infection. researchers found that coffee consumption showed a positive dose-response relation in reduced active stomach lining infection and after adjusted odds ratios, patients who drank < 3 cups and > or = 3 cups of coffee per day displayed the relative risk ratio of 1.49 and 2.49 respectively, in compared to nondrinkers.

The result suggested that coffee intake showed negative effects attenuated in the course of H pylori-induced active infection. In other words, coffee intake may elevate active infection caused by bacterial H pylori.
Others, in the study of a sample of 238 subjects (hospital employees) initially (in 1994) seronegative to H. pylori tested again 5 years later (1999), in two different periods (1994 and 1999). returned questionnaire from patients showed a neutral effect between coffee consumption and risk of infection caused by H. pylori regardless of numbers of cup intake daily and after taking into account other factors.
More importantly, in the investigation of the effect of coffee consumption on four major acid-related diseases: gastric ulcer (GU), a serve case of gastric infection, duodenal ulcer (DU), reflux esophagitis (RE), and non-erosive reflux disease (NERD) based on the large-scale multivariate analysis of the 9,517 healthy adults, researchers filed the following results in related to coffee intake and risk of Helicobacter pylori (HP) infection
1. Coffee consumption expressed a relatively low ratio of pepsinogen I/II
2. Coffee intake expressed a positively related risk of Helicobacter pylori (HP) infection by multiple logistic regression analysis,
3. Coffee intake was not associated with either GU or DU

But after taking into account other risk factors, researchers exemplified that " There is no significant relationship between coffee consumption and the four major acid-related upper gastrointestinal disorders".

With all the information collected, coffee intake may have a very significant and neutral link to an increased risk of Gastritis caused by a bacterial infection, therefore, clarification by large sample size and cohost studies are necessary,


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Relation of smoking and alcohol and coffee consumption to active Helicobacter pylori infection: a cross-sectional study by Brenner H1, Rothenbacher D, Bode G, Adler G.(PubMed)
(2) Relationship of smoking and coffee and alcohol consumption with seroconversion to Helicobacter pylori: a longitudinal study in hospital workers by Gikas A1, Triantafillidis JK, Apostolidis N, Mallas E, Peros G, Androulakis G.(PubMed)
(3) No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan by Shimamoto T1, Yamamichi N, Kodashima S, Takahashi Y, Fujishiro M, Oka M, Mitsushima T, Koike K(PubMed)

#Healthyfood #Cranberry Exhibits Plasma #Antioxidant Capacity in Clinical Trials, Researchers Suggest

By Kyle J. Norton

Free radicals are unstable molecules with unpaired electrons in the outermost ring produced daily internally including cell metabolism and externally including the air we breathe and the food we eat.
Reactive oxygen species and reactive nitrogen without being controlled by antioxidant can induce a domino's effect by stealing an electron from other molecules, leading to a continued reaction that cannot stop until all single electrons are paired or inhibited by the presence of antioxidant molecules.

Antioxidants are stable atoms produced either by the host body or intake of dietary antioxdant rich food.

In this cascade, free radicals overexpression induces oxidative stress. A major cause of protein, lipid, and cell damage increases the risk of the early onset of many chronic diseases.

In other words, oxidative stress is an imbalanced ratio of the free radicals and antioxidants.

Most common diseases or syndromes associated with the onset of oxidative stress are
* Aging, is a process characterized by the progressive loss of tissue and organ function due to the accumulation of RONS-induced damages.

* Cardiovascular diseases (CVD) are diseases associated with involving the heart or blood vessels, including heart disease, and stroke.

* Chronic obstructive pulmonary disease (COPD) is a class of lung disease including chronic bronchitis and emphysema. Most cases of COPD are caused by smoking.

* Chronic kidney disease is a medical condition that causes the gradual loss of kidney function, affecting filter wastes and excess fluids from the blood.

* Neurodegenerative diseases is the progressive loss of structure or function of neurons, including dementia.
* Cancer is the class of diseases caused by irregular cell growth due to the alternation of cell DNA

There are many risk factors that can increase the overexpression of free radicals, including fried foods, alcohol, tobacco smoke, pesticides, and air pollutants.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of cranberry products and especially cranberry juice (CJ) antioxidant activity.

According to the tested analysis on the products, the order of the number of total polyphenols that exert antioxidant activity in cranberry foods on a fresh weight basis is dried > frozen > sauce > jellied sauce. in decreasing order.

Furthermore, in the comparison of the effect of the consumption of high fructose corn syrup (HFCS) and ascorbate with CJ antioxidants or without CJ (control) given to 10 normal individuals after an overnight fast, by recording the plasma antioxidant capacity, glucose, triglycerides, and ascorbate measured 6 times over 7 h after the consumption of a single 240 mL serving of the two different beverages, researchers found that* HFCS caused a slight decrease in plasma antioxidant capacity at all time points and thus inducing oxidative stress with or without ascorbate
*CJ produced an increase in plasma antioxidant capacity at all time points, particularly compared to
HFCS.

Furthermore, postprandial triglycerides-induced oxidative stress caused by HFCS was associated with the oxidative stress in HFCS treated group.

Based on the findings, researchers said, " Cranberries are an excellent source of high-quality antioxidants and should be examined in human supplementation studies".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry by Baranowska M1, Bartoszek A. (PubMed)
(2) Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants by Vinson JA1, Bose P, Proch J, Al Kharrat H, Samman N. (PubMed)

#Healthyfood #Asparagus Exhibits Anti-#LiverCancer, in Vitros and Vivos, According to Scientists

By Kyle J. Norton

Asparagus is a flowering plant belonging to species of the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia. Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties. 

Cancer is a class of diseases in which a group of cells growing and multiplying in disordered and uncontrollable ways in our body, have become progressively worse and damage other healthy tissues, sometimes spreading to other organs in the body via lymph or blood and results may be in death.

Liver Cancer is defined as a condition of the abnormal proliferation of cells in the liver.

Its chemical constituents include essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin.

Asparagus may be one of the potential herbs used in the future to treat liver cancers as its chemical constituents exert their anti-cancer properties in many studies.

Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies in the world, but deproteinized asparagus polysaccharide exerts potent selective cytotoxicity against hepatocellular carcinoma Hep3B and HepG2 cells. in vitro and in vivo, according to the researcher's team led by Dr. Xiang J. Others in the analysis of Shatavari IV isolated from ethyl acetate insoluble fraction (AR-2B) of chloroform: methanol (2:1) (AR-2) extract of A. racemosus roots, indicated that Shatavari exhibits significant anticancer activity in both in vitro and in vivo experimental models. 

In fact, intakes of celery, mushrooms, allium vegetables, composite vegetables (including asparagus lettuce and garland chrysanthemum), legumes, and legume products were widely known to associate with reduced liver cancer risk.

Reference
(1) Chemical constituents of Asparagus J. S. Negi, P. Singh, [...], and V. K. Bisht (PubMed)
(2) Anticancer effects of deproteinized asparagus polysaccharide on hepatocellular carcinoma in vitro and in vivo. by Xiang J, Xiang Y, Lin S, Xin D, Liu X, Weng L, Chen T, Zhang M.(PubMed)
(3) Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus. by Mitra SK, Prakash NS, Sundaram R.(PubMed)
(4) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies. by Zhang W, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO.(PubMed)

#Herbal #Ashwagandha Shows a Significant Effect on #ColonCancer in Vitros and Vivos, According to Studies

By Kyle J. Norton

Cancer is a group of chronic diseases caused by irregular cell growth in the tissue of a specific organ due to the alternation of cell DNA.

Colon cancer is a chronic condition characterized by uncontrolled cell growth in the colon tissue.

Most cases of colon cancer start with the alternation of cells DNA in the cells on the surface of the inner lining colon tissue before proliferating into deeper tissues to form a tumor through abnormal cell cycle division.

The colon formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colon cancer is relatively very common, slowly growing, and progressing cancer.

According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.

In 2019, 101,420 people in the US will be diagnosed with colon cancer.

The most common symptoms of colon cancer are a persistent change in your bowel habits, including diarrhea or constipation, blood in your stool, and persistent abdominal discomforts, such as feeling that your bowel doesn't empty completely accompanied by some general symptoms shared by other types of cancer.

The exact causes of colon cancer are unknown. However, out of many risk factors associated with the onset of the disease, aging may have a strong implication involved in cancer, as most cases of colon are found in the older population.

Dr. O Ng and colleagues in a joint study led by the University of Nottingham wrote, "The prevalence of colorectal cancer is increasing in the elderly. We examined the treatment and outcomes in our institution of patients aged over 85 years with proven colorectal adenocarcinoma".


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potential compound for the treatment of colon cancer with no side effect, researchers examined the effects of Withaferin-A, a withanolide derived from the leaf extract of W. somnifera, anti-colon tumor activity.

On human colorectal cancer (HCT116) cells, the phytochemical not only inhibited the proliferation but also the migration of the tested cancer cells in a concentration-dependent manner.

In other words, Withaferin-A exhibited cell cycle arrest and blocked cancer cell spreading.

Furthermore, the administration of withaferin-A attenuated the expression of pro-inflammatory cytokines activated by protein (STAT3) associated with the development and progression of colon cancer.

On HCT116 cells xenograft tumors generated in Balb/c nude mice, withaferin-A showed a strong activity in which a significant decrease in the volume and weight of tumors, compared to untreated controls.

Based on the finding, researchers said, "The present study suggests that withaferin-A holds the potential to be developed as a small molecule inhibitor of STAT3 for the treatment of HCT116".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of colon cancer in vitro and vivo.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity by Choi BY1, Kim BW. (PubMed)
(2) Immunomodulatory effects of Withania somnifera on azoxymethane-induced experimental colon cancer in mice by Muralikrishnan G1, Dinda AK, Shakeel F. (PubMed)
(3) Colorectal cancer outcomes in patients aged over 85 years by O Ng,1 E Watts,2 CA Bull,2 R Morris,3 A Acheson,2 and A Banerjea. (PMC)

#Lycopenes Exhibit Antioxidant Activities Against the Risk of #HepaticSteatosis and #NonAlchololicFattyLiverDisease In Vivos

By Kyle J. Norton

The liver is the largest internal organ that filters the blood from the digestive tract, before passing them to the rest of the body.
The liver also plays an essential role to produce cholesterol to build a strong cell wall, produce steroid hormones and vitamin D and aid the digestive function in food absorption and detoxify chemicals and metabolizes drugs.

Hepatic steatosis is a medical condition that reduces the function of the liver caused by the accumulation of fat in the liver.


In other words, if the intrahepatic fat of your liver is more than 5% of liver weight, you are considered to have hepatic steatosis. Epidemiologically, over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.

Hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication and/or hepatic disorders.

Most common risk factors associated with the onset of hepatic steatosis are insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, using hepatotoxic medications total parenteral nutrition (TPN).

The increased flux of fatty acids to the liver, de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion are some mechanisms that cause the accumulation of intrahepatic fat.

Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.

Dr. Michael D. Roberts, the lead scientist said, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content,...in adult Brown Norway rats".

And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes".

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the prevention of liver disease, researchers examined the effects of lycopene on hepatic steatosis in an animal model.

In a model of high-fat diet rats, lycopene not only showed a significant effect against the development of steatohepatitis but also inhibited nonalcoholic steatohepatitis (NASH) in the promotion of the early stage of liver cancer through its antioxidant activity.

In rats induced NAFLD by a hypercholesterolemic and high-fat diet, according to the tested analysis, after 7 weeks, there are clear differences in the classical antioxidant biomarkers and metabolic pattern associated with the inhibition of NAFLD between the diet and intake of lycopene from tomato juice.

Interestingly, tomato juice administration partially reverted the metabolic pattern from a high-fat diet to a normal diet in metabolites without exhibiting the redox state.

Taken altogether, lycopene found in tomatoes may be considered a supplement for the improvement of liver metabolism against the risk of liver disease, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months)

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(2) Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice by Ip BC1, Liu C2, Lichtenstein AH3, von Lintig J4, Wang XD. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)

#Antioxidant #Quercetin Found in #Onion Inhibits Parameters that Cause #CardiovascularDiseases, According to Studies

By Kyle J. Norton

Vasoprotection is the process to improve the function of the blood vessels, including the use of herbal and natural remedies.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.

There 3 main types of blood vessels arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.

The veins carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.

The capillaries or the smallest blood vessels that have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.


Endothelial dysfunction is a condition characterized by the damage of the vascular endothelium, the thin layer of cells that lines blood vessels, a leading cause of cardiovascular disease (CVD).

In other words, vascular endothelium dysfunction reduced the function of targeting free radicals that lead to the onset of oxidative stress.

The most common risk factors associated with vascular endothelium dysfunction are impaired vasodilation, deficiency of nitric oxide, inflammation, and thrombosis.

Conventionally, treatments of vascular endothelial dysfunction are totally depending on the causes of the disease. Early detection has been found to play a critical role that recovers endothelial function".

Dr. Hirata Y. at The University of Tokyo.wrote, "Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function".

And, "There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes bodyweight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta-blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants".


The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

On finding a potent ingredient that processes vasoprotective activity researchers examined quercetin, a dietary polyphenol found abundantly in onion on vascular endothelial dysfunction (VED).

Epidemiologically, quercetin showed significant activity against the VED complication in the induction of oxidative stress, impaired vasodilation, platelet aggregation, and monocyte adhesion leading to the early event of morbidity and mortality in patients with cardiovascular disease (CVD).

Quercetin efficacy which protects against VED and decreases CVD risk was attributed to its antioxidant, vasodilatory, anti-platelet, and anti-atherogenic activities.

Furthermore, in vitro, quercetin exerted multiple actions on the NO-guanylyl cyclase pathway associated with the smooth muscle tone in bronchi or vessels, endothelium-derived hyperpolarizing factor(s), and endothelin-1 involved in vasoconstriction and endothelial function.

Moreover, the phytochemical also protected endothelial cells against apoptosis.

In vivo, quercetin prevented endothelial dysfunction by reducing blood pressure, oxidative stress, and end-organ damage in hypertensive animals.

In other words, regular intake of quercetin improves the endothelium functioning against the risk of VED-inducing cardiovascular disease, particularly in patients with hypertension and ischemic heart disease.

Taken altogether, onion processed with a higher amount of quercetin may be considered a remedy for the prevention and treatment of vascular endothelial dysfunction, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vasoprotective activities of quercetin by Richard S Bruno. (Research Gate)
(2) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols by Perez-Vizcaino F1, Duarte J, Andriantsitohaina R. (PubMed)
(3) Diagnosis and treatment of endothelial dysfunction in cardiovascular disease by Hirata Y1, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R. (PubMed)