#Phytochemical #Indicaxanthin Inhibits The Risk of Abnormal Intestinal Contractions That Cause Inflammations & Abdominal Cramps

By Kyle J. Norton

Intestinal motility disorders is a condition associated with abnormal intestinal contractions, such as spasms and intestinal paralysis.

In a healthy individual, intestinal muscles contract and relax in a coordinated, rhythmic fashion that propels food to each stage of digestion. However, in patients with intestinal motility disorders, food passes at each stage are reduced or blocked due to abnormal intestinal muscle motility.

The most common symptoms of intestinal motility disorders are difficulty swallowing, GERD., gas, severe constipation, diarrhea, abdominal pain, vomiting, and bloating.

In other words, intestinal motility disorders cause various digestive symptoms.

The most common causes of intestinal motility disorders are associated with the problem of the muscle that controls peristalsis or the nerves or hormones that control the muscle's contractions.

Certain diseases such as irritable bowel syndrome (IBS), gastroparesis, esophageal spasms, diabetes, and Hirschsprung's disease are also linked to the onset of intestinal motility disorders.

Dr. Deane AM, the led scientist in the examination of conventional treatment of intestinal motility disorders, said, "Gastrointestinal dysmotility causes delayed gastric emptying, enteral feed intolerance, and functional obstruction of the small and large intestine, the latter functional obstructions being frequently termed ileus and Ogilvie syndrome".

And, "While the administration of either metoclopramide or erythromycin is supported by evidence it appears that dual-drug therapy (erythromycin and metoclopramide) reduces the rate of treatment failure...Several drugs, including ghrelin agonists, highly selective 5-hydroxytryptamine receptor agonists, and opiate antagonists are being studied in clinical trials. Neostigmine, when infused at a relatively slow rate in patients receiving continuous hemodynamic monitoring, may alleviate the need for endoscopic".

Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

According to the Università di Palermo, phytochemical Indicaxanthin may process the function that inhibits the risk of abnormal intestinal contractions associated with the ability gut to coordinate muscular activity.

Abnormal intestinal contractions in the gut have been found to induce inflammation and abdominal cramps.

More precisely, indicaxanthin induced inhibitory effects on the abnormally spontaneous mechanical activity of the gut-associated with an enzyme that causes muscle constriction.

Furthermore, the phosphodiesterases (PDEs) function that regulated contraction and relaxation of smooth musculature induced by the expression of 3-isobutyl-1-methylxanthine (IBMX) was modulated by the injection of indicaxanthin.

Moreover, administration of indicaxanthin and IBMX, a pan-specific inhibitor of phosphodiesterases also significantly reduced the carbachol-evoked contractions with no side effects.

And, both indicaxanthin and IBMX increased the inhibitory effects of forskolin associated with muscle relaxant effects with no adverse effects.

In other words, Phytochemical indicaxanthin increased both basal and forskolin involved in muscle relaxant activity in mouse ileal muscle by inhibiting the mechanisms associated with motility disorders.

Dr. Baldassano S, the lead scientist said, "indicaxanthin reduces the contractility of ileal longitudinal muscle by inhibition of PDEs and increase of cAMP concentration and raise the possibility of using indicaxanthin in the treatment of motility disorders, such as abdominal cramps".

Taken altogether, indicaxanthin may be considered a remedy for preventing and treating motility disorders, pending confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action by Baldassano S1, Rotondo A, Serio R, Livrea MA, Tesoriere L, Mulè F. (PubMed)
(2) Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill by Deane AM1, Chapman MJ2,3, Reintam Blaser A4,5, McClave SA6, Emmanuel A. (PubMed)

# Kidney Bean Processes Antioxidant Activities that Regulate Inflammation, Resdearchers Say

By Kyle J. Norton

Kidney bean is popular because of its kidney shape, strong flavor, and color of reddish-brown in nature, It is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.
According to the joint study led by Nanchang University, kidney beans exhibited strong antioxidant activities through the levels of total phenolics and flavonoids with respective values compared to 0.25-3.79 mg gallic acid and 0.19-7.05 mg rutin found in analyzed chemical compounds assay.

In ultra-performance liquid chromatography with a diode array detector (UPLC-DAD), kidney bean processed the antioxidant activity (AA) ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg and radicals inhibited by 50% (EC50)concentration.

The extracts of the kidney were also found to have the capability of inhibiting the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2) cells, human breast cancer cells MCF-7, and A549 NSCLC cell line through its antioxidant effects.


Dr. Ombra MN, the lead author said, "Cultivars differed in composition and concentration of polyphenols including anthocyanins; cooking affected the antioxidant activity only marginally."
Further to the study to compare the antioxidant activity of two solvents, aqueous (70%) acetone, and water, and the extract with their phenolic contents, researchers found that aqueous acetone (70%) extracted containing more than twice of phenolics from hulls exhibited significantly higher antioxidant and stronger inhibitory effect on both cyclooxygenases, COX-1 and COX-2, (in the expression of inflammation and inflammation in the gastrointestinal tract) than water in regulated inflammation.

Dr. Oomah BD the lead author in the compared study said, "antioxidant activity that was significantly affected by cultivar and extracting solvent".

Taken together, kidney beans exhibited a strong antioxidant effect through their procession of various phytochemical compounds, such as total phenolics and flavonoids, in regulated inflammation caused by free radicals and microbial invasion.


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Sources
(1) Nutrients, phytochemicals, and antioxidant activities of 26 kidney bean cultivars by Kan L1, Nie S2, Hu J1, Wang S3, Cui SW4, Li Y1, Xu S1, Wu Y1, Wang J1, Bai Z1, Xie M1. (PubMed)
(2) Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L.) Endemic Ecotypes of Southern Italy before and after Cooking. by Ombra MN1, d'Acierno A1, Nazzaro F1, Riccardi R2, Spigno P2, Zaccardelli M3, Pane C3, Maione M1, Fratianni F1. (PubMed)
(3) Antioxidant and anti-inflammatory activities of bean ( Phaseolus vulgaris L.) hulls by Oomah BD1, Corbé A, Balasubramanian P.(PubMed)

#Herbal #Turmeric Inhibits the Onset of #Gastric/StomachUlcer, According to Studies

By Kyle J. Norton

Gastric or stomach ulcer is a condition of localized tissue erosion in the lining of the stomach.
The most common symptoms of gastric ulcers are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding, unintended weight loss and loss of appetite, and gastrointestinal discomforts.

Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.

The imbalance between stomach acid and upper GI tract mucosa is the main cause of the condition onset associated with the use of certain medications, including aspirin, non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, and chronic gastritis.

Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation, and critical illness are at an increased risk of gastric ulcer.

According to studies gastric ulcers can be preventable, you can protect yourself against the risk of gastric ulcers by
1. Adding dietary phytosterols and phospholipids
Experiments using animal peptic ulcer models showed that the lipid fraction in foods from the staple diets of low prevalence areas gave protection against both gastric and duodenal ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), and also promoted healing of ulceration.

2. Reducing intake of NSAID
NSAID has been proven to cause gastric Ulcers (9), by inhibiting the body’s production of prostaglandins, hormones that protect the stomach lining.

3. Quitting smoking
Cigarette smoking increases xanthine oxidase activity, leukotrienes, nitric oxide production, and also neutrophil infiltration in the gastric mucosa(13).

4. Not missing your dental appointment
The study showed that a significantly higher proportion of subjects with peptic ulcer reported that they lost five or more teeth (35.3 vs. 17.4%, p<0.001) or that they were told they had periodontitis (33.5 vs. 20.7%, p<0.001)(8).

5. Reducing stress
Stress had been found to increase the onset of gastric ulcers in people who suffered from the Great East Japan earthquake and tsunami. The incidence of all types of peptic ulcers was 1.5-fold increased after the earthquake.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of gastric ulcers, researchers examined the intact (TrPP) and modified, and the low-molecular-weight (MTrPP) forms of pectic polysaccharides isolated from turmeric against a gastric ulcer in vitro and in vivo models.

Compared to TrPP, MTrPP possessed a significantly better ulcer-preventive property by inhibiting ulcer scores up to 85%.

More precisely, MTrPP exerted an effective much-protection, inhibited the expression of H(+), K(+)-ATPase in the ulcer forming and of H. pylori growth/adherence, and higher antioxidant/cytoprotective mechanisms associated with the gastric lesion.

By comparing the chemical contents in TrPP, and MTrPP, researchers suggested that the efficacy of MTrPP in the protection against the formation of the gastric ulcer may be attributed to the levels of galacturonic acid (687mg/g; TrPP-544mg/g) and galactose (52.9%; TrPP-21.7%) in the inhibition of inflammation.

In other words, the low molecular weight of MTrPP (155kDa; TrPP-13kDa) possesses higher antiulcer potential compared to that of TrPP.

In order to reveal more information about turmeric anti-gastric ulcer activity, researchers evaluated the effect of C. Angustifolia and M. arundinacea on forced swimming-induced hypothermia and gastric ulceration in rats.

According to the observation of 72 hours periodically and mortality recorded up to seven days, the application of both drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg.

Both the test drugs showed a significantly reversed stress-induced gastric ulceration compared to stress-control rats.

Taken altogether, curcumin used in the intact (TrPP) and modified, and the low-molecular-weight (MTrPP) forms may be considered a remedy for the prevention and treatment of gastric ulcers, pending to large sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer by Harsha MR1, Chandra Prakash SV1, Dharmesh SM. (PubMed)
(2) Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of by Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.).
Rajashekhara N1, Ashok BK2, Sharma PP3, Ravishankar B. (PubMed)
(3) Gastric Ulcers: Preventions – The do and do not’s list by Kyle J. Norton

#Healthyfood #Broccoli and #Tomato Inhibit the Risk of Insulin Resistance Associated with #Hormone #Resistin, According to Studies

By Kyle J. Norton

Insulin resistance is a hallmark of type 2 diabetes characterized by the inability of the body to use the insulin produced by the pancreas properly.
In other words, signals sent out by the hormone insulin caused by clog-up of the insulin receptors was ignored by the cell of the muscles, body fat, and liver that process the function to convert glucose into energy.

More precisely, as the clogged-up insulin receptors ignore the signals of the hormone insulin, insulin resistance develops, leading to more production of insulin by the beta cells and over time causing permanent damage to the cells in the pancreas.

Epidemiologically, people with insulin resistance are associated with an increased risk of prediabetes, type 2 diabetes and chronic conditions such as heart attacks, strokes, and cancer.

A 2016 joint study led by MSA University, suggested that tomato and broccoli extract affects on glucose homeostasis in high-fat diet-induced obesity in rats by regulating the adipocyte hormone Resistin.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

Tomato is red, edible fruit, genus Solanum, and belongs to the family Solanaceae, native to South America. Because of its health benefits, tomato is grown worldwide for commercial purpose
and often in the greenhouse.
According to US statistics, approximately, 60 to 70 million individuals are affected by insulin resistance with 40% of individuals older than 50 years may be at risk of insulin resistance.

Believe it or not, the most common risk factors associated with insulin resistance are obesity and hypertension associated with the promotion of a high-fat diet over the past few decades.

Dr. Merat S, the lead scientist wrote, " Contrary to expectation, IR was induced in mice fed the Western diet,,,. The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".

A total of 48 male albino rats included in the study were divided into 8 groups as follows: control, HFD, stop fat diet (SD), Tomato 200 mg/kg (T200), Tomato 400 mg/kg (T400), Broccoli 200 mg/kg (B200), Broccoli 400 mg/kg (B400), and Chromax (CX).

According to the tested differentiation after 1 month of treatment,

* Serum levels of resistin were significantly reduced in all groups treated with tomato, broccoli, and CXIn other words, T 200, T 400, B 200, B 400 and CX groups reduced levels of resistin to: 4.13 ± 0.22 ng/ml, 1.51 ± 0.04 ng/ml, 4.13 ± 0.22 ng/ml, 2.32 ± 0.15 ng/ml, and 1.37 ± 0.03 ng/ml, compared to the baseline, respectively.

Where resistin is an adipocyte hormone associated with regulating glucose metabolism. Elevated levels of resistin have been found to cause insulin resistance in diabetics.

Increased levels of Serum levels of leptin significantly reduced anti-elevated levels of resistin in the T 400 group compared to the B 400 and CX groups.

Additionally, serum levels of adiponectin associated with insulin resistance were significantly increased in the T 400 group (131 ± 3.84 pg/ml).

The results strongly suggested that broccoli and tomato extract inhibited the elevated levels of hormone resistin that cause insulin resistance in the high-fat-diet-induced diabetes animal model.

Based on the finding, researchers said, " tomato and broccoli extract treatment regulates glucose homeostasis via reduction of serum resistin and may be a useful non-pharmacological therapy for obesity".

Taken altogether, broccoli and tomato extract may be considered supplements for the prevention and treatment of insulin resistance, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Resistin mediates tomato and broccoli extract effects on glucose homeostasis in high fat diet-induced obesity in rats by Aborehab NM1, El Bishbishy MH2, Waly NE. (PubMed)
(2) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)

#Healthyfood #BlackBeans in Reducing the Risk of #ChronicDiseases, According to Scientists

By Kyle J. Norton

Intake of black beans regularly may have a potential effect on attenuated risk and treatment of chronic diseases.
Chronic diseases, not prevented by vaccines or cured by medication are any diseases that last over 3 months or more.

Black beans, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was the first domesticated growth in South America.

According to the University of Colorado Colorado Springs, the efficacy of legumes in reducing chronic illness risk may be attributed to antioxidant phytochemical activities as well as other responses that influenced the classification of types of diseases such as diabetes, CVD, and cancer.

In protein and four synthesized pure peptides isolated Mexican black and Brazilian Carioca beans showed potential and therapeutic effects in treating antidiabetic and antihypertensive mice regardless of their antioxidant capacity.

In fact, according to the Universidad Complutense de Madrid, types of carbohydrates found in black beans may be associated with a low glycemic response, low serum cholesterol levels, and a decrease of colon cancer risk factors as well as other forms of chronic diseases such as diabetes type II and cardiovascular diseases.

Collectively, black beans reduced the risk and treatment of chronic illness and are the result of improved antioxidant status and other mechanisms, including reduction of glucose, triglycerides, total cholesterol, lower levels of LDL, and Raised HDL as well as protecting pancreatic ß-cells, ...

Taking together, there is no doubt that black beans may be used as functional foods in attenuating the risk and treatment of chronic disease, through antioxidant, anti-inflammatory, anti-proliferative, cardioprotective..... activities.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress by Mojica L1,2, Luna-Vital DA1,3, González de Mejía E1.(PubMed)
(3) [Role of black bean Phaseolus vulgaris on the nutritional status of Guatemalan population].
[Article in Spanish]by Serrano J1, Goñi I.(PubMed)

#Antioxidant #Allicin Processes #Antibiotic-Like Properties, According to Studies

By Kyle J. Norton

Phytochemical Allicin may be the next generation of natural antibiotic alternatives for the prevention and treatment of infectious diseases caused by the bacterium, some studies suggested.
Allicin is phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.

Under normal conditions, the immune system does a great job of keeping people healthy and preventing infections.

Foods and nutritional supplements, herbs may also play an important role in enhancing the immune system's defense against viruses and bacteria attacks.

Infection is a result of the battle between the invasion of foreign organisms' body tissues by disease-causing agents and the reaction of the immune system response.

Infectious disease is a condition caused by prolonged infection and the failure of the macrophages, the body's first line of defense of the immune system to completely destroy the invasive pathogens through the production of pro-inflammatory cytokines in the acute phase of infection.

Antibiotics are the most common treatment for infectious diseases. Treatment can be targeted more precisely with the diagnosis. The application of Antibiotics in most cases is quite effective in reversing bacterial infections.

However, by killing the infectious bacteria and healthy cells nearby, the medication may induce some side effects such as common gastrointestinal discomforts.

In serious cases, the use of antibiotics may also cause blood in the stool and persistent and intense stomach cramping or pain and uncontrol vomiting.

If you currently taking antibiotics, please make sure that you know all the side effects for preventive measures.

The research team of infectious disease at The Hebrew University-Hadassah School of Dental Medicine in the concerns of the side effects of antibiotics launched an investigation to test the antimicrobial activity of garlic allicin on oral pathogens associated with dental caries and periodontitis.

The experiment found that Allicin is effective against all the tested bacteria.

Injection of the broth dilution from Allicin inhibited the planktonic growth of the cariogenic, gram-positive species Streptococcus mutans, S. sobrinus, and Actinomyces oris at the concentration of 600 μg/mL or higher.

Gram-negative etiopathogenic species Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum were inhibited by a minimum allicin concentration of 300 μg/mL.


Allicin at the concentration of (2,400 μg/mL). exerted the lowest effect against Porphyromonas gingivalis, an anaerobic, gram-negative pathogen and the bacterium most associated with chronic periodontitis.

Further analysis also discovered that Allicin inhibited levels of the arginine and lysine gingipains, the major virulence factors of this organism.

And, A gingipain-inactivated mutant demonstrated high sensitivity to allicin (<300 μg/mL), revealing that gingipains confer resistance to allicin.

After taking into account co and confounders, Dr. Bachrach G, the lead author wrote in the final report, "These results support the traditional medicinal use of garlic and suggest the use of allicin for alleviating dental diseases".

Additionally, in the reaffirming of the effects of Allicin against Streptolysin O (SLO), a potent cytolytic toxin and an important virulence factor produced by almost all strains of group A streptococci researchers revealed that application of Allicin neutralizes SLO in a dose- and time-dependent manner.

Moreover, A 15 min incubation of SLO with 35 microg allicin totally inhibited the hemolytic activity of SLO [IC(50) (concentration necessary to reach half-maximum inhibition)=5.97 microg], the was equipotency similar to those of pure allicin (IC(50)=6.27 microg; P<0.05).


In contrast, a fresh extract of garlic inhibited the SLO hemolytic activity at lower concentrations (IC(50)=1.59 microl; 1.9 microg allicin).

These results suggested that Allicin and allicin may be potential alternative drugs against streptococcal diseases.

Taken altogether, Allicin found in great amounts in garlic may be considered a functional bioactive compound for the prevention and treatment of bacterial infection, depending on the result of a larger sample size and multicenter in the human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Garlic allicin as a potential agent for controlling oral pathogens by Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D.(PubMed)
(2) Inhibition of streptolysin O by allicin - an active component of garlic by Arzanlou M, Bohlooli S.(PubMed)

#Phytchoemical #Alliin Found in #GarlicPowders Gobbles Up #Cancer Cells through Its AFBI Detoxification, According to Researchers

By Kyle J. Norton

Cancer is a class of diseases caused by irregular cell growth in the tissue or organ associated with the alternation of cell DNA.
Most cancers at the early stage, due to the small size of the tumor are asymptomatic, However, as the cells continue to proliferate, at some points, the tumor may affect the nearby blood vessels and nerve cells leading to symptoms of severe pain and bleeding accompanied by the general symptoms shared by all cancers.

Most primary cancers at the advanced stage can also travel a distance away from the original site to infect other healthy tissues, leading to secondary metastasis.

According to the statistics provided by the National Cancer Institute, based on 2011–2015 statistics. approximately, 439.2 per 100,000 men and women per year are diagnosed with cancer. The number of cancer deaths is 163.5 per 100,000 men and women per year, also based on 2011–2015 statistics.
Cancers are classified depending on the types of cells alternation
* Carcinoma
Carcinoma is a malignant tumor found in anywhere of the epithelial tissues lining the cavities, surfaces of structures, and glands.

* Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells that originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.

* Lymphoma and leukemia
Hematopoietic cells are multipotent stem cells that give rise to all types of blood cells, including red blood cells, white blood cells, and platelets that become cancerous.

* Germ cell tumor
Cancer is derived from pluripotent cells. In adults, these are most often found in the testicle and ovary, However, the cancer is more common in babies and young children.

* Blastoma
The cancer is derived from immature "precursor" or embryonic tissue. These are also most common in children.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find the potential treatment of cancer with no side effects, researchers examined the protective effect of three garlic powders compared to that Alliin.

Rats selected for the study were administered for 2 weeks with a 5% garlic powder diet.
According to the comet assay, consumption of the different garlic powders induced a 35-60% reduction in DNA damage induced by N-nitroso dimethylamine (NDMA) in rat liver.

Compared to the other garlic powders increased alliin content of the garlic powder was associated strongly with a proportional decrease in NDMA-induced DNA alteration.

In other words, alliin increased the anti-liver cancer activity of garlic powder proportionally compared to normal garlic powders.

Interestingly, DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon was also decreased strongly by the three garlic powders but these decreases were not correlated to the alliin content of the garlic powder.

In other words, all phytochemical compounds found in the garlic powder must work together to augment the anti-cancer effect regardless of the content of the individual compound.

In the study of liver cancer induced by injections of 0.025 mg/kg body weight aflatoxin B1 (AFB1) in rats, researchers garlic powder decreased the appearance and size of hepatic GST-P foci associated with early markers of liver cancer.

However, garlic containing the highest level of alliin showed a stronger effect in the protection of the liver against the forming hepatic GST-P foci compared to the normal garlic powders.

Levels of alliin showed an inverse association with the number and area of preneoplastic foci.

Garlic powder ingestion increased the activity of hepatic detoxified enzymes such as glutathione S-transferase and UDP glucuronosyltransferase with no modification of nifedipine oxidase activity.

Dr. Bergès R, the lead researcher said, "It is suggested that garlic partly exerts its anticarcinogenic effects through increasing enzymes involved in AFB1 detoxification. This study highlights the possibility of controlling the cultivation conditions to improve the chemopreventive efficacy of garlic".

Taken altogether, alliin may be considered a supplement for the prevention and treatment of cancer with no side effects, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats by Bergès R1, Siess MH, Arnault I, Auger J, Kahane R, Pinnert MF, Vernevaut MF, le Bon AM. (PubMed)