#Kidneybeans Process Anti-Proliferative Effects on #Leukemia, Researchers Suggest

By Kyle J. Norton

Intake of cooked Dried red kidney beans regularly may reduce the risk and delay the progression risk of Leukemia, a renowned institute study proposed.

Kidney bean is a popular food, with a kidney shape, strong flavor, and color reddish-brown in nature used often as an excellent dietary selection because of its enormous health benefits with a good source of protein and minerals.

Leukemia is a condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chemical compound purified from dried kidney beans, namely, 7.3-kDa antifungal peptide, used mainly for the treatment of fungal overgrowth, showed to suppress the spread of leukemia L1210 cells with a half concentration of 5.2±0.4 µM and 7.6±0.6 µM, according to the China Agricultural University.

Dr. Ma DZ, the lead researcher said, "(the antifungal peptide isolated from dried Nepalese large red beans) exerted an antiproliferative action on L1210 leukemia cells with an an half concentration of high doses at 15 and 60 microM, respectively".

Other chemical compound, L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds also enhanced anti-proliferative effect on ALL cells according to the WST-8 cell viability assay kit.

Furthermore, treatment of L-asparaginase enzyme also involved significantly in induced early apoptosis in acute Lymphoblastic leukemia in test subjects in vivo.

According to the joint study led by King Abdulaziz University, the efficacy of a novel L-asparaginase enzyme, isolated from Phaseolus vulgaris seeds (P-Asp) in mice study showed that mice treated with P-Asp had less distinct allergenic responses by the immune system in expression of higher risk of carcinogens and reduced treatment effects.

There is no doubt that kidney beans may be a potential health benefit in targeting the risk of Leukemia in the early stage and prevent the progression of cancer through anti-proliferative and induced tumors cell death.


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Sources
(1) An antifungal peptide with antiproliferative activity toward tumor cells from red kidney beans by Li M1, Wang H, Ng TB.(PubMed)
(2) A peptide with potent antifungal and antiproliferative activities from Nepalese large red beans by Ma DZ1, Wang HX, Ng TB.(PubMed)
(3) Trypsin isoinhibitors with antiproliferative activity toward leukemia cells from Phaseolus vulgaris cv "White Cloud Bean" by Sun J1, Wang H, Ng TB.(PubMed)
(4) Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells by Li M1,2, Liu Q3, Cui Y4, Li D5, Wang H6, Ng TB7.(PubMed)

#Phytochemical #AnacardicAcid Exerts Antibiotic-Like Properties, Researchers Say

By Kyle J. Norton

Scientists may have found a bioactive compound for the replacement of antibiotics with no side effects, some studies suggested.
Infection is a human disease characterized by the invasion of an organism that multiplied in a specific tissue or organ.

In bodily injury due to physical impact, the white blood cells of the immune first line of defense stimulate the production of proteins associated with the coagulation to cover the wound against the entrance of the microorganisms and inflammatory cytokines to kill off the infectious pathogens before they can enter the body and cause damage.

Most microorganisms were killed in the acute phase of the infection.


The infection is progressing through 5 stages, including
1. The incubation stage is a stage that microorganisms have successfully entered the host and started a period of multiplication. At this period patients do not experience any symptoms.

2. The prodromal stage, followed after the incubation period, after gaining strength in numbers and continued multiplication, the presence of the invasive pathogens is noticed by the immune system, leading to an immune system response. At this period, patients may experience symptoms of fever, pain, and swelling.

3. The stage of illness is a stage the disease is formed with signs and symptoms of the disease are most obvious and severe.

4. The stage of decline, the stage that saw the immune system has won the battle. In this stage, the number of pathogens and the signs and symptoms of illness begin to decline.

5. The stage of convalescence is a stage of recovery.

Some scientists in the study of the immune evolution suggested that the immune system is designed to kill off invasive pathogens in 3-8 weeks, otherwise, it will adapt to the change, leading to diseases associated with chronic infection.

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

With an aim to find a natural antibiotic for the replacement of conventional medicine for the prevention and treatment of microbial infection, researchers examined the anacardic acid mixture antibacterial quorum sensing (QS), which is a process of bacterial cell-cell communication that controls a large number of systems affecting pathogenicity.

An anacardic acid mixture (AAM) used in the experiment was produced by the A. astringent hexane extract (HE) in the bacterial strain Chromobacterium violaceum.

By comparing the 2 extracts, researchers found that
* HE induced a 91.6% of inhibition of the violecin production at 55 μg/mL concentration, whereas AAM showed 94% of inhibition at 166 μg/mL.

* Interestingly, both extracts were found to inhibit violacein production affecting the viability of the bacterium.* Furthermore, AAM inhibited the substance which stimulates redox cycling in bacteria (pyocyanin 86% at 200 μg/mL) and glycolipid biosurfactants of bacterial structure (rhamnolipid, 91% at 500 μg/mL) production in a dose/response form and decreases the elastase (75% at 500 μg/mL) activity in P. aeruginosa without affecting its development.

Where violecin is a naturally-occurring bis-indole pigment with antibiotic properties produced by the bacteria.

These results indicated that Anacardic acid disrupts the quorum sensing (QS) of bacteria by inhibiting the substances which play a critical role in microbial survival in cell-cell communication.

Dr.Castillo-Juárez I, the lead scientist said, " Anacardic acids mixture isolated from A. astringent demonstrated anti-QS, it could be further exploited for novel molecules to treat the emerging infections of antibiotic-resistant bacterial pathogens".

Additionally, in the evaluated new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds isolated from the bark of Amphipterygium astringent using a bioassay-guided fractionation method, researchers showed that compounds 1-4 exhibited antibacterial activity against Streptococcus mutants and Porphyromonas gingivalis with minimum inhibitory concentrations ranging from 7 to 104 µg mL and from 12 to 126 µg mL.

Where compounds 1-4 are 6-[16'Z-nonadecenyl]-salicylic acid (1), 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0), (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4).

Taken altogether, anacardic acid and its bioactive derivatives may be considered antibiotics alternative for the prevention and treatment of bacterial infection with no side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Amphypterygium adstringens anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa by Castillo-Juárez I, García-Contreras R, Velázquez-Guadarrama N, Soto-Hernández M, Martínez-Vázquez M. (PubMed)
(2) Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis by Rivero-Cruz BE, Esturau N, Sánchez-Nieto S, Romero I, Castillo-Juárez I, Rivero-Cruz JF.(PubMed)

#Phytochemical #Alliin Balances the Gut Microbiota Through #Antiinflammatory and #AntiFreeRadical Activities, Scientists Show

By Kyle J. Norton

Gut microbiota refers to the population of microbes living in the gut. The community contains tens of trillions of microorganisms with over 1000 different species of bacteria.

The gut microbiota plays a vital role in human health, including the key processes of nutrition-enhancing the digestive functioning, lipid, and energy metabolism by inducing the production of short-chain fatty acids (SCFAs), phenolics, and other molecules, and pathogen resistance by promoting the immune function.

In a healthy individual, the levels of gut microbiota are balanced that allows the body to function in an optimal way.

Furthermore, gut microbiota also is found to stimulate the production of some vitamins (B and K), digest certain foods that the stomach and small intestine have not been able to digest, particularly in the combat against the aggression of other bad microorganisms.

However, alterations in gut microbiota composition have been found in patients with a low-grade inflammatory state, leading to an increased risk of several diseases, including type 2 diabetes mellitus and cardiovascular disease.

Although the digestive tract can adapt to change, the loss of balance in gut microbiota may induce dysbiosis., leading to health problems of functional bowel disorders, inflammatory bowel disease, allergies, obesity, and diabetes.

The are many risk factors associated with gut microbiota imbalance. Some researchers suggested that the major causes of the condition may be a result of the promotion of a high-fat diet over the past few decades.

Dr. Duo Li, at the Institute of Nutrition and Health at Qingdao University in China, and colleagues wrote, "“Western-type diet has a strong effect on the genetic composition and metabolic activity of gut microbiota,” they wrote. “Evidence has shown that in humans gut microbiota diversity and richness are reduced when comparing such high-fat diets with more traditional diets with relatively higher proportions of carbohydrates. Such diet-induced ‘dysbiosis’ in gut-associated microbial communities has been postulated as a major trigger of metabolic impairments associated with obesity".

Alliin (S-allyl-L-cysteine-S-oxour intestinal chemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on the mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.


Before being treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, and production of proinflammatory cytokines, including IL-1beta and TNF-alpha.

Furthermore, the pokeweed mitogen (PWM) treated group also showed reduced levels of both the percentage of phagocyting cells and the number of latex particles associated with the immune functions of phagocytosis.

Administration of garlic derivative alliin not decreased only the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.

In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.

On finding a natural compound for the improvement of the ratio of gut microbiota, researchers examined whether different plant-derived components with similar anti-oxidative and anti-inflammatory functions such as quercetin and alliin in traditional Asian diet on the status of the gut microbiota and colonic epithelial immunity.

Traditional Asian diet significantly increased reshaped the gut microbiota composition by significantly increased the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health.

In other words, the traditional Asian diet reduced the expression of bad bacteria and increased the good bacteria in the gut.

The consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways immunomodulatory effect in improving the gut immunity through their anti-inflammatory and anti-free radical activities.

In other words, the alternate consumption of quercetin and alliin can contribute to beneficial metabolic effects by optimizing gut microbiota by improving the immunologic function of colonic epithelial cells associated with the innate immune defense.

Taken altogether, alliin may be considered a supplement for the improvement of gut microbiota inducing immunologic function of colonic epithelial cells associated with the innate immune defense, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(2) High-fat diet linked to unfavorable gut microbiota changes by Wan Y. (Healio Gastroenterology)

#Antioxidant #Soysaponin Found in #Herbal #Alfalfa Reduces the Risk of High Blood Cholesterol, Researchers Say

By Kyle J. Norton

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae. It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc. North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.

Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place. If you have too much low-density lipoprotein LDL which is known as bad cholesterol, over time cholesterol can build up in your arterial walls causing blockage and leading to heart attack and stroke.

In the study of 15 patients with hyperlipoproteinemia who were given 40 g of heat prepared alfalfa seeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged diet, the herb shows in lowering of pretreatment median values of total plasma cholesterol from 9.58 to 8.00 mmol/l (P less than 0.001) and low-density lipoprotein (LDL) cholesterol decreases of 17% and 18%, respectively. Another study also indicated that the constituents of soysaponin I (I), azukisaponin V (II) found in Alfalfa might process the potential in treating high blood cholesterol. In an animal study, a hen fed with aqueous alfalfa extract (AAE) shows lower serum low and high-density lipoprotein cholesterol, serum total triglycerides, and liver cholesterol concentration (day 42), lipid indices in the yolk, serum, and liver.


References
(1) Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia. by Mölgaard J, von Schenck H, Olsson AG. (PubMed)
(2) [Study on the chemical constituents from the aerial parts of Medicago sativa and their hypolipidemic activity].[Article in Chinese] by Yu CH, Liang DL, Guo JN, Mei QX, Yang DP. (PubMed)
(3) Effects of an aqueous alfalfa extract on production performance, egg quality and lipid metabolism of laying hens by Deng W, Dong XF, Tong JM, Xie TH, Zhang Q.(PubMed)

#Healthyfood #NavyBean in the Promotion of #ColonHealth, According to Studies

By Kyle J. Norton

Metabolite markers are the reaction of the metabolites that respond sensitively to phytochemical exposure.
Phytochemicals are plant-based natural components that form an important part of the human diet and animal feed. Synthetic phytochemicals are also commonly found in dietary supplements and pharmacological agents.

Phytochemicals are chemical compounds produced by plants to protect them against predators such as insects and bacteria and fungi. Some phytochemicals are also used in traditional medicine to combat diseases.

According to Prof. Chi Chen in the investigation of the metabolite markers of phytochemicals wrote, "the bidirectional interactions between phytochemicals and the metabolic system, such as the disposition of phytochemicals, the regulation of nutrient, antioxidant, and microbial metabolism, and overdose-induced toxicities".

In other words, phytochemicals including bioactive phytochemicals play an essential role in regulating the metabolic system through many metabolic pathways.

Believe it or not, metabolic effects have a strong impact on phytochemicals on the digestion, absorption, distribution, and metabolism of nutrients and antioxidants.

On the digestive system, bioactive phytochemicals play an essential role in the human diet as a valuable source of many bioactive components: phenolic compounds, vitamins or bioactive peptides.

On chronic diseases, consumption of total phytochemical intake has been found to reduce the risk of cardiovascular disease, cancer, and neurodegenerative diseases.


On the metabolism of nutrients, gene-phytochemical interactions are individual differences depending on the individual genetic proposition, including the capacity to influence disease risk via several complementary and overlapping mechanisms.


More precisely, a person's genetic variation in pathways has a strong effect on the absorption, metabolism, and distribution of phytochemicals that expose at the tissue level or alter the biological response.

From an antioxidant perspective, although phytochemicals and antioxidants are different, phytochemical antioxidants capacity demonstrated potential effects on oxidative status, that decrease the risk of proteins, lipids, and cellular damage.

Collectively, by looking at the forms of metabolite markers, and the tested assays after exposure to phytochemicals, researchers may know the inaction of the phytochemical and metabolic system.


The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

With an aim to find a natural compound for the promotion of gut health, researchers examined and investigated metabolite markers of dry bean consumption in parallel human and mouse studies.

The study included 46 men who received a dry bean enriched diet (250 g/day) for 4 weeks and 12 mice that received a standardized diet containing either 0 or 10% navy bean ethanol extract for 6 weeks.

According to the self-reported compared to the baseline, serum pipecolic acid (PA) and S-methyl cysteine (SMC) were elevated after dry bean consumption in human and mouse studies.


In other words, serum levels of pipecolic acid and S-methyl cysteine are metabolite markers that are useful to measure the amount of dry and navy bean consumption.

More precisely, according to the unpaired t-tests, a navy bean extract-enriched diet altered 26 metabolites (9% of analyzed metabolites) at P < 0.05 and 7 metabolites (2.4%) at q < 0.05 using unpaired t-tests; the most significant being PA, SMC, and NAO (all q < 0.003).


Furthermore, identifying the biomarkers of dry (navy) bean intake may improve the understanding of the effect of navy beans in reducing the risk of colorectal cancer.

In intestinal microbial metabolism, the conversion of lysine to pipecolic acid (PA) may confer chemopreventive benefits for the human host because PA is a precursor of microbial compounds with anti-inflammatory properties.

Taken altogether, the dry beans including navy bean may be considered a remedy for the improvement of colon health, through its metabolite markers, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies by Perera T1, Young MR, Zhang Z, Murphy G, Colburn NH, Lanza E, Hartman TJ, Cross AJ, Bobe G. (PubMed)
(2) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(3) Metabolite Markers of Phytochemicals by Prof. Chi Chen (Metabolites)

#Herbal #Turmeric Protects the Stomach Against the Onset of #Gastritis, Researchers Say

By Kyle J. Norton

Gastritis is a group of conditions associated with the inflammation of the lining of the stomach caused by infection of the bacterium, leading to stomach ulcers developing.
A stomach ulcer is an open sore in the lining of the stomach. In most cases, it is a result of bacterial infection that leads to the erosion of the gastric lining by stomach acid.

Other causes of gastritis are long-term excessive alcohol consumption and the use of certain medications such as aspirin.

There are 2 types of gastritis
* Acute gastritis occurs suddenly as a result of inflammation or swelling in the lining of the stomach. and only affects the stomach and induces nausea or vomiting,

* Chronic gastritis is a condition that develops slowly due to chronic inflammation or damage of the stomach lining that has not healed.

Patients with chronic gastritis if untreated were found to have a substantial risk of stomach cancer.
The most common symptoms of gastritis are a burning sensation or pain in the upper abdomen, nausea, vomiting, and abnormal feeling of fullness in the upper abdomen after eating.


Out of many risk factors involved in the onset of the condition, some researchers in the observation of the correlation of high-fat diet-induced obesity over the past few decades, in the risk of gastritis wrote, "Obesity has become a major concern among gastroenterologists due to its large influence on gastrointestinal and hepatic diseases: reflux esophagitis, pancreatitis, gallstone disease, liver fibrosis, and neoplastic tumors of the esophagus, pancreas, and colon".

And, "the effects of obesity on endoscopic gastritis in subjects undergoing health check-up examination, and demonstrated that adiponectin, a bioactive molecule released from visceral fat, could be a protective factor of endoscopic gastritis".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of gastric inflammation, researchers examined the effect of diterpenoid C extracted from radix curcumae on Helicobacter pylori (H. pylori)-infected inflammation, and intestinal metaplasia.

The study included human gastric epithelial gastric epithelium cell line (GES-1) infected by I-type H. pylori treated with radix curcumae (RC)-derived diterpenoid C of different concentrations (5, 10, 20 μg/mL) and amoxicillin.

According to the MTT assay, IC5 of RC-derived diterpenoid C and amoxicillin of 5 μg/mL inhibited the progression rate of GES-1.

The combination also inhibited the production of pro-inflammatory cytokines and exhibited the production of anti-inflammatory cytokines associated with the injection of I-type H. pylori in the GES-1,
particularly, at 12, 24, 48, and 72 h points.

In other words, the combination protects the stomach against gastric inflammation by blocking the activation of a protein involved in the stimulation of pro-inflammatory cytokines.


Based on the findings, researchers wrote, "RC-derived diterpenoid C can block NF-κB signal pathway, effectively reducing the secretion of H. pylori-induced proinflammatory cytokine and increasing the secretion of anti-inflammatory cytokine".

In Helicobacter pylori infection of the lining of the stomach induces an array of inflammatory cytokine production that leads to gastritis and peptic ulcer disease, researchers at the Uttaradit Hospital conducted an experiment to investigate the effect of curcumin on the production of interleukin (IL)-8, IL-1beta, tumor necrosis factor (TNF)-alpha and cyclooxygenase (COX)-2 in gastric mucosa from H. pylori-infected gastritis patients.


Selected patients were randomly assigned to receive either OAM (Omeprazole, Amoxicillin, and Metronidazole) treatment and/or a course of curcumin.

According to the tested assays, curcumin alone may have a limited anti-bactericidal effect on H. pylori, and on the production of inflammatory cytokines compared to those of the OAM group.

However, the curcumin group showed significant relieving symptoms with a lower rate in the eradication rate of H. pylori and no decreased cytokine production.

Precisely, curcumin used alone has limited efficacy compared to that of the combination in reducing gastric inflammation.

Taken altogether, turmeric processed abundant bioactive ingredient curcumin may be combined with other conventional medicines for the prevention and treatment of gastric inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways by Huang X1, Lv B, Zhang S, Dai Q, Chen BB, Meng LN. (PubMed)
(2) Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients by Koosirirat C1, Linpisarn S, Changsom D, Chawansuntati K, Wipasa J. (PubMed)
(3) Is obesity a new risk factor for gastritis? by Yamamoto S1, Watabe K, Takehara T. (PubMed)

The #Antioxidant #Andrographolide (Andro) Isolated From #Herbal #Andrographis Effects on Cancers, According to Scientists

By Kyle J. Norton

Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chickenpox, etc.

Cancer is a class of diseases in which a group of cells growing and multiplying in disordered and uncontrollable ways in our body, have become progressively worse and damage other healthy tissues, sometimes spreading to other organs in the body via lymph or blood and results may be in death.

Andrographolide (Andro), a diterpenoid, isolated from Andrographispaniculata, has exerted its anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines. In another study, Andrographolide, a chemical constituent isolated from the leaves of Andrographis paniculata Nees, significantly reduced the expression of hVEGF-A165 compared with a mock group in the Clara cells of the lungs and its anticancer and immunomodulatory activities may be potential to provide a cure for pulmonary tumors and a cancer therapeutic agent in the future.


References
(1) Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines. by Yunos NM, Mutalip SS, Jauri MH, Yu JQ, Huq F.(PubMed)
(2) Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas. by Tung YT, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM.(PubMed)
(3) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. by Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in the male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)